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Affordability, accessibility and availability of health care coupled with disproportionate growth and double burden of diseases have become major concerns in India. This article emphasizes need for mindset change from illness-disease-drug centric curative to person-health-wellness centric preventive and promotive approaches. It highlights innovation deficit faced pharmaceutical industry and drugs being withdrawn from market for safety reasons. Medical pluralism is a growing trend and people are exploring various options including modern, traditional, complementary and alternative medicine. In such a situation, knowledge from Ayurveda, yoga, Chinese medicine and acupuncture may play an important role. We can evolve a suitable model by integrating modern and traditional systems of medicine for affordable health care. In the larger interest of global community, Indian and Chinese systems should share knowledge and experiences for mutual intellectual enrichments and work together to evolve a novel model of integrative medicine.",{"EN":118},"Search of novel model for integrative medicine",{"VOID":120},"[\"14361329092543204547\"]",{"VOID":122},"Patwardhan B. Traditional medicine: modern approach for affordable global health. Commission on Intellectual Property, Innovation and Public Health, World Health Organization, Geneva 2005. http:\u002F\u002Fwww.who.int\u002Fintellectualproperty\u002Fstudies\u002FB.Patwardhan2.pdf\nSample Registration Bulletin 2011. Registrar General of India, New Delhi. http:\u002F\u002Fcensusindia.gov.in\u002Fvital_statistics\u002FSRS_Bulletins\u002FBulletins.html\nNational Health Profile 2010. Central Bureau of Health Intelligence, New Delhi. http:\u002F\u002Fcbhidghs.nic.in\u002Fwritereaddata\u002FmainlinkFile\u002FFile1166.pdf\nhttp:\u002F\u002Fwww.who.int\u002Fdiabetes\u002Factionnow\u002Fen\u002Fmapdiabprev.pdf\nhttp:\u002F\u002Fwww.whoindia.org\u002FSCN\u002FAssBOD\u002F08-Hypertension.pdf\nNational Family Health Survey-III (2005–06), MOHFW\u002FGOI. http:\u002F\u002Fwww.measuredhs.com\u002Fpubs\u002Fpdf\u002FFRIND3\u002FFRIND3-Vol1AndVol2.pdf\nAmrith SS. Health in India since independence. Working Paper 79. February 2009, Brooks World Poverty Institute, Manchester. http:\u002F\u002Fwww.bwpi.manchester.ac.uk\u002Fresources\u002FWorking-Papers\u002Fbwpi-wp-7909.pdf\nReddy KS, Patel V, Jha P, Paul VK, Kumar AKS, Dandona L. Towards achievement of universal health care in India by 2020: a call to action. Lancet 2011;377:760–768.\nNational Healthcare Disparities Report, 2011. Agency for Healthcare Research and Quality, USA. http:\u002F\u002Fwww.ahrq.gov\u002Fresearch\u002Ffindings\u002Fnhqrdr\u002Fnhqrdr11\u002Fqrdr11.html\nPatwardhan B, Mashelkar RA. Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward? Drug Discov Today 2009;14:804–811.\nHarmon K. Prescription Drug deaths increase dramatically. Scientifi c American 2010, Apr 6. http:\u002F\u002Fwww.scientificamerican.com\u002Farticle.cfm?id=prescription-drug-deaths\nPujol A, Mosca R, Farrés J, Aloy P. Unveiling the role of network and systems biology in drug discovery. Trends Pharmacol Sci 2010;31:115–123.\nhttp:\u002F\u002Fen.wikipedia.org\u002Fwiki\u002FList_of_withdrawn_drugs\nBalasubramani SP, Venkatasubramanian P, Kukkupuni SK, Patwardhan B. Plant-based Rasayana drugs from Ayurveda. Chin J Integr Med 2011;17:88–94.\nPatwardhan B, Vaidya ADB, Chorghade M, Joshi SP. Reverse pharmacology and systems approaches for drug discovery and development. Curr Bioa Compounds 2008;4:201–212.\nPatwardhan B, Vaidya ADB. Natural products drug discovery: accelerating the clinical candidate development using reverse pharmacology approaches. Indian J Exp Biol 2010;48:220–227.\nPatwardhan B. The quest for evidence based Ayurveda: lessons learned. Curr Sci 2012;102:1406–1417.\nSingh RH. Holistic principles of Ayurvedic medicine. New Delhi: Choukhamba Surbharati Publications, 2002.\nPatwardhan B, Bodeker G. Ayurvedic genomics: establishing a genetic basis for mind-body typologies. J Altern Complement Med 2008;14:571–576.\nBarker DJP. Developmental origins of adult health and disease. J Epidemiol Community Health 2004;58:114–115.\nShannahoff-Khalsa DS. An introduction to Kundalini yoga meditation techniques that are specific for the treatment of psychiatric disorders. J Altern Complement Med 2004;10:91–101.\nWerntz DA, Bickford RG, Bloom FE, Shannahoff-Khalsa DS. Alternating cerebral hemispheric activity and the lateralization of autonomic nervous function. Hum Neurobiol 1983;2:39–43.\nShannahoff-Khalsa DS, Kennedy B, Yates FE, Ziegler MG. Low-frequency ultradian insulin rhythms are coupled to cardiovascular, autonomic, and neuroendocrine rhythms. Am J Physiol 1997;272:R962–R968.\nMorris K. Meditating on yogic science. Lancet 1998;351:1038.\nGarfinkel MS, Singhal A, Katz WA, Allan DA, Reshetar R, Schumacher HR Jr. Yoga-based intervention for carpal tunnel syndrome: a randomized trial. JAMA 1998;280:1601–1603.\nBernardi L, Sleight P, Bandinelli G, Cencetti S, Fattorini L, Wdowczyc-Szulc J, et al. Effect of rosary prayer and yoga mantras on autonomic cardiovascular rhythms: comparative study. BMJ 2001;323:1446–1449.\nCohen L, Warneke C, Fouladi RT, Rodriguez MA, Chaoul-Reich A. Psychological adjustment and sleep quality in a randomized trial of the effects of a Tibetan yoga intervention in patients with lymphoma. Cancer 2004;100:2253–2260.\nVisweswaraiah NK, Telles S. Randomized trial of yoga as a complementary therapy for pulmonary tuberculosis. Respirology 2004;9:96–101.\nBlanke O, Ortique S, Landis T, Seeck M. Stimulating illusory own-body perceptions. Nature 2002;419:269–270.\nTong F. Out-of-body experiences: from penfi eld to present. Trends Cogn Sci 2003;7:104–106.\nBhushan P, Kalpana J, Arvind C. Classifi cation of human population based on HLA gene polymorphism and the concept of prakriti in Ayurveda. J Altern Complement Med 2005;11:349–353.\nJoshi K, Ghodke Y, Patwardhan B. Traditional medicine to modern pharmacogenomics: Ayurveda prakriti type and CYP2C19 gene polymorphism associated with the metabolic variability. Evid Based Complement Alternat Med 2011;2011:249528.\nJoshi K, Ghodke Y, Shintre P. Traditional medicine and genomics. J Ayurveda Integr Med 2010;1:26–32.\nDobos G, Tao I. The model of Western integrative medicine: the role of Chinese medicine. Chin J Integr Med 2011;17:11–20.\nPatwardhan B, Warude D, Pushpangadan P, Bhatt N. Ayurveda and traditional Chinese medicine: a comparative overview. Evid Based Complement Alternat Med 2005;2:465–473.\nRobinson N. Integrative medicine-traditional Chinese medicine, a model? Chin J Integr Med 2011;17:21–25.\nChandra S. Status of Indian medicine and folk healing. Part I and Part II, Department of AYUSH, Government of India, New Delhi 2012, 2013. http:\u002F\u002Fissuu.com\u002Fknowledgeforall\u002Fdocs\u002Fayush_report_partii\u002F\nPatwardhan B, Vaidya ADS. Ayurveda: scientifi c research and publications. Curr Sci 2009;97:1117–1121.\nPatwardhan B, Joglekar V, Pathak N, Vaidya A. Vaidyascientists: catalysing Ayurveda renaissance. Curr Sci 2011;100:476–483.\nBodekar G. WHO, Global atlas on traditional medicine, 2008. http:\u002F\u002Fapps.who.int\u002Fbookorders\u002Fanglais\u002Fdetart1.jsp?codlan=1&codcol=15&codcch=614\nPlanning Commission, Government of India, 2012 Steering Committee Report on Health Sector. http:\u002F\u002Fplanningcommission.nic.in\u002Faboutus\u002Fcommittee\u002Findex.php?about=12strindx.htm\nSchmittdiel JA, Brown SD, Neugebauer R, Adams SR, Adams AS, Wiley D, et al. Health-plan and employerbased wellness programs to reduce diabetes risk: the kaiser permanente Northern California NEXT-D Study. Prev Chronic Dis 2013;10:120146.\nWorld Health Organization: Traditional Medicine Factsheet. 2008 (http:\u002F\u002Fwww.who.int\u002Fmediacentre\u002Ffactsheets\u002Ffs134\u002Fen\u002F)\nWeil A. Integrative medicine: a vital part of the new health care system, Testimony before the Committee on Health, Education, Labor and Pensions United States Senate, February 26, 2009. http:\u002F\u002Fwww.help.senate.gov\u002Fimo\u002Fmedia\u002Fdoc\u002FWeil.pdf\nHaramati A. New Indo-US partnership in Ayurveda. J Ayurveda Integr Med 2010;1:89–90.\nShankar D. Conceptual framework for new models of integrative medicine. J Ayurveda Integr Med 2010;1:3–5.\nPatwardhan B. Health for India: search for appropriate models. J Ayurveda Integr Med 2012;3:173–174.\nPatwardhan B. Planned progress for health. J Ayurveda Integr Med 2011;2:161–162.\nPatwardhan B. Ayurveda and integrative medicine: riding a tiger. J Ayurveda Integr Med 2010;1:13–15.",{"VOID":124},"10.1007\u002Fs11655-014-1745-2","PUBLICATION","VERIFIED","2024-05-10T17:33:04.956+00:00","Auto Verify","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs11655-014-1745-2",[131,149],{"id":132,"sortIndex":23,"researcher":22,"roles":133,"affiliations":135,"properties":144,"displayName":146,"givenName":22,"familyName":22},"f9ab550e-a999-4647-8c2e-7d04ee3722a2",[134],"AUTHOR",[136],{"id":137,"sortIndex":23,"affiliation":138,"properties":22},"bbd59493-57e5-43f6-8393-ec8342c6f9c8",{"id":137,"createTime":22,"updateTime":22,"relativeEntities":139,"slug":22,"properties":140,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":143,"statistic":22},[],{"title":141},{"VI":142},"Interdisciplinary School of Health Sciences, University of Pune, Pune, India",[],{"title":145,"gsAuthor":147},{"VI":146},"Bhushan Patwardhan",{"VOID":148},"[\"egxm6oIAAAAJ\"]",{"id":150,"sortIndex":98,"researcher":22,"roles":151,"affiliations":152,"properties":161,"displayName":163,"givenName":22,"familyName":22},"76cbeb36-159a-49ec-8897-fc33f5b30727",[134],[153],{"id":154,"sortIndex":23,"affiliation":155,"properties":22},"efec5f1c-d04c-4af8-8acc-b0f0e14cad01",{"id":154,"createTime":22,"updateTime":22,"relativeEntities":156,"slug":22,"properties":157,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":160,"statistic":22},[],{"title":158},{"VI":159},"Former Director, WHO Liaison Office New York, New York, USA",[],{"title":162},{"VI":163},"Gururaj Mutalik","ARTICLE",{"url":129,"publisher":166,"properties":216},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":167,"slug":10,"properties":168,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":172,"manageAffiliations":185,"indexDatabases":196,"url":22,"thumbnailPath":22,"statistic":211,"gsStatistic":22,"type":103,"analyzePriority":22},[],{"issn":169,"title":170,"eissn":171},{"VOID":15},{"EN":17},{"VOID":13},[173,177,181],{"id":26,"createTime":22,"updateTime":22,"relativeEntities":174,"label":175,"description":176,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":29},{},{"id":32,"createTime":22,"updateTime":22,"relativeEntities":178,"label":179,"description":180,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":35},{},{"id":38,"createTime":22,"updateTime":22,"relativeEntities":182,"label":183,"description":184,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":41},{},[186,191],{"id":45,"createTime":22,"updateTime":22,"relativeEntities":187,"slug":22,"properties":188,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":190,"statistic":22},[],{"title":189},{"EN":49},[],{"id":52,"createTime":22,"updateTime":22,"relativeEntities":192,"slug":22,"properties":193,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":195,"statistic":22},[],{"title":194},{"EN":56},[],[197,204],{"id":60,"indexDatabase":198,"url":71,"indexYears":72,"academicFieldIds":203,"indexDatabaseRanking":22},{"id":62,"createTime":22,"updateTime":22,"relativeEntities":199,"label":200,"description":201,"key":68,"publicationTags":202,"standard":22},[],{"EN":65,"VI":65},{"EN":65,"VI":67},[70],[74,75,76],{"id":78,"indexDatabase":205,"url":91,"indexYears":22,"academicFieldIds":210,"indexDatabaseRanking":22},{"id":80,"createTime":22,"updateTime":22,"relativeEntities":206,"label":207,"description":208,"key":87,"publicationTags":209,"standard":22},[],{"EN":83,"VI":83},{"EN":85,"VI":86},[89,90],[93],{"impactFactor":23,"impactFactorByYear":212,"i10Index":23,"i10IndexLast5Year":23,"totalPublication":96,"totalPublicationByYear":213,"totalCitation":23,"totalCitationByYear":214,"totalCitationPerPublication":23,"totalCitationPerPublicationByYear":215,"hindexLast5Year":23,"hindex":23},{},{"1995":98,"1996":98,"1997":99,"2000":98,"2001":98,"2002":100},{},{},{"pages":217,"volume":219},{"VOID":218},"170-178",{"VOID":220},"20",13,{"total":221,"publishYear":223,"statisticByYear":224},2014,{"2014":99,"2015":98,"2019":98,"2020":99,"2021":98,"2022":98,"2023":98,"2025":100},"2014-03-04","ERROR_IN_ANALYZE_CITATION","2026-08-14T10:20:39.525+00:00",[70,89],false,{"id":231,"createTime":232,"updateTime":233,"relativeEntities":234,"slug":235,"properties":236,"entityType":125,"verifyStatus":126,"verifyTime":247,"verifyNote":128,"languages":22,"translateLanguages":22,"viewCount":23,"primaryUrl":248,"fullTextUrl":22,"authors":249,"publicationType":164,"publisherRelationship":364,"citationCount":23,"citationInfo":420,"publishDate":423,"publishYear":421,"citationAnalyzeStatus":226,"lastCitationAnalyze":424,"indexDatabases":425,"openAccess":22,"references":22,"isForceReanalyzing":229},"ed795423-91d5-42b7-80c8-f57358e6f5d1","2024-02-19T09:55:30.989+00:00","2026-08-14T00:43:51.611+00:00",[],"Huangqin-Decoction-Delays-Progress-of-Colitis-Associated-Carcinogenesis-by-Regulating-Nrf2-HO-1-Antioxidant-Signal-Pathway-in-Mice",{"abstract":237,"title":239,"gsPaper":241,"references":243,"doi":245},{"EN":238},"To investigate the effect of Huangqin Decoction (HQD) on nuclear factor erythroid 2 related-factor 2 (Nrf2)\u002Fheme oxygenase (HO-1) signaling pathway by inducing the colitis-associated carcinogenesis (CAC) model mice with azoxymethane (AOM)\u002Fdextran sodium sulfate (DSS). The chemical components of HQD were analyzed by liquid chromatography-quadrupole-time-of-flight mass spectrometry (LC-Q-TOF-MS\u002FMS) to determine the molecular constituents of HQD. Totally 48 C57BL\u002F6J mice were randomly divided into 6 groups by a random number table, including control, model (AOM\u002FDSS), mesalazine (MS), low-, medium-, and high-dose HQD (HQD-L, HQD-M, and HQD-H) groups, 8 mice in each group. Except for the control group, the mice in the other groups were intraperitoneally injected with AOM (10 mg\u002Fkg) and administrated with 2.5% DSS orally for 1 week every two weeks (totally 3 rounds of DSS) to construct a colitis-associated carcinogenesis mouse model. The mice in the HQD-L, HQD-M and HQD-H groups were given HQD by gavage at doses of 2.925, 5.85, and 11.7 g\u002Fkg, respectively; the mice in the MS group was given a suspension of MS at a dose of 0.043 g\u002Fkg (totally 11 weeks). The serum levels of malondialdehyde (MDA) and superoxide dismutase (SOD) were measured by enzyme-linked immunosorbent assay. The mRNA and protein expression levels of Nrf2, HO-1, and inhibitory KELCH like ECH-related protein 1 (Keap1) in colon tissue were detected by quantitative real-time PCR, immunohistochemistry, and Western blot, respectively. LC-Q-TOF-MS\u002FMS analysis revealed that the chemical constituents of HQD include baicalin, paeoniflorin, and glycyrrhizic acid. Compared to the control group, significantly higher MDA levels and lower SOD levels were observed in the model group (P\u003C0.05), whereas the expressions of Nrf2 and HO-1 were significantly decreased, and the expression of Keap1 increased (P\u003C0.01). Compared with the model group, serum MDA level was decreased and SOD level was increased in the HQD-M, HQD-H and MS groups (P\u003C0.05). Higher expressions of Nrf2 and HO-1 were observed in the HQD groups. HQD may regulate the expression of Nrf2 and HO-1 in colon tissue, reduce the expression of MDA and increase the expression of SOD in serum, thus delaying the progress of CAC in AOM\u002FDSS mice.",{"EN":240},"Huangqin Decoction Delays Progress of Colitis-Associated Carcinogenesis by Regulating Nrf2\u002FHO-1 Antioxidant Signal Pathway in Mice",{"VOID":242},"[\"14236260696829535238\"]",{"VOID":244},"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68:394–424.\nRobles AI, Traverso G, Zhang M, Roberts NJ, Khan MA, Joseph C, et al. Whole-exome sequencing analyses of inflammatory bowel disease-associated colorectal cancers. Gastroenterology 2016;150:931–943.\nGuan Q. A comprehensive review and update on the pathogenesis of inflammatory bowel disease. J Immunol Res 2019;2019:7247238.\nTian T, Wang ZL, Zhang JH. Pathomechanisms of oxidative stress in inflammatory bowel disease and potential antioxidant therapies. Oxid Med Cellular Longev 2017;2017:1–18.\nAcevedo-León D, Monzó-Beltrán L, Pérez-Sánchez L, Naranjo-Morillo E, Gómez-Abril SÁ, Estañ-Capell N, et al. Oxidative stress and DNA damage markers in colorectal cancer. Int J Mol Sci 2022;23:11664.\nPompili S, Sferra R, Gaudio E, Viscido A, Frieri G, Vetuschi A, et al. Can Nrf2 modulate the development of intestinal fibrosis and cancer in inflammatory bowel disease?. Int J Mol Sci 2019;20:4061.\nArab HH, Al-Shorbagy MY, Saad MA. Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: targeting AMPK\u002FmTOR, HMGB1\u002FRAGE and Nrf2\u002FHO-1 pathways. Chem Biol Interact 2021;335:109368.\nLiu MR, Li H, Wei LF, Liu XT, An ZT, Gu LM, et al. Effects of Huangqin Decoction on NLRP3\u002FCaspase-1 pathway in mouse model of ulcerative colitis. China J Chin Materia Med (Chin) 2023;48:226–233.\nGu LM, Li H, Xia JQ, Pan CY, Gu C, Tian YZ. Huangqin Decoction attenuates DSS-induced mucosal damage and promotes epithelial repair via inhibiting TNF-α-induced NF-κB activation. Chin J Integr Med 2022;28:124–129.\nWirtz S, Popp V, Kindermann M, Gerlach K, Weigmann B, Fichtner-Feigl S, et al. Chemically induced mouse models of acute and chronic intestinal inflammation. Nat Protoc 2017;12:1295–1309.\nWu Y, Liu X, Li G. Integrated bioinformatics and network pharmacology to identify the therapeutic target and molecular mechanisms of Huangqin Decoction on ulcerative colitis. Sci Rep 2022;12:159.\nHuang J, Jiang T, Kang J, Xu J, Dengzhang Y, Zhao Z, et al. Synergistic effect of Huangqin Decoction combined treatment with Radix Actinidiae chinensis on DSS and AOM-induced colorectal cancer. Front Pharmacol 2022;13:933070.\nParang B, Barrett CW, Williams CS. AOM\u002FDSS model of colitis-associated cancer. Methods Mol Biol 2016;1422:297–307.\nWang Z, Ma L, Su M, Zhou Y, Mao K, Li C, et al. Baicalin induces cellular senescence in human colon cancer cells via upregulation of DEPP and the activation of Ras\u002FRaf\u002FMEK\u002FERK signaling. Cell Death Dis 2018;9:217.\nSi XL, Wang Y, Song BN, Zhang Y, Yang QX, Li Z, et al. Potential chemoprevention of paeoniflorin in colitis-associated colorectal cancer by network pharmacology, molecular docking, and in vivo experiment. Chem Biodivers 2022;19:e202200295.\nZuo Z, He L, Duan X, Peng Z, Han J. Glycyrrhizic acid exhibits strong anticancer activity in colorectal cancer cells via SIRT3 inhibition. Bioengineered 2022;13:2720–2731.\nSajadimajd S, Khazaei M. Oxidative stress and cancer: the role of Nrf2. Curr Cancer Drug Targets 2018;18:538–557.\nKhor TO, Huang MT, Prawan A, Liu Y, Hao X, Yu S, et al. Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer. Cancer Prev Res (Phila) 2008;1:187–191.\nLong M, Tao S, Rojo de la Vega M, Jiang T, Wen Q, Park SL, et al. Nrf2-dependent suppression of azoxymethane\u002Fdextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde. Cancer Prev Res (Phila) 2015;8:444–454.\nWang X, Saud SM, Wang F, He S, Zhang X, Hua B, et al. Protective effect of Shaoyao Decoction on colitis-associated colorectal cancer by inducing Nrf2 signaling pathway. J Ethnopharmacol 2020;252:112600.\nMcCord JM, Edeas MA. SOD, oxidative stress and human pathologies: a brief history and a future vision. Biomed Pharmacother 2005;59:139–142.\nAyala A, Muñoz MF, Argüelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev 2014;2014:360438.\nLi R, Chen Y, Shi M, Xu X, Zhao Y, Wu X, et al. Gegen Qinlian Decoction alleviates experimental colitis via suppressing TLR4\u002FNF-κB signaling and enhancing antioxidant effect. Phytomedicine 2016;23:1012–1020.\nWang R, Luo Y, Lu Y, Wang D, Wang T, Pu W, et al. Maggot extracts alleviate inflammation and oxidative stress in acute experimental colitis via the activation of Nrf2. 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investigate whether the dried root of Phellodendron amurense Ruprecht (Phellodendri cortex; PC) extract improves arthritic symptoms through anti-inflammatory and immune-modulatory effects in collagen-induced arthritis in mice. Rheumatoid arthritis (RA) was induced in male DBA\u002F1 mice by immunization with type II collagen (ColII). CIA mice were divided into 5 groups (n=10 per a group) with normal, CIA control, PC extract (50 mg\u002Fkg and 100 mg\u002Fkg)-treated, and meloxicam (50 mg\u002Fkg)-treated as the reference drug. The PC extract or meloxicam were administered orally in CIA mice once a day for 14 days after arthritis induction. Arthritic score, levels of anti-ColII IgG2a antibody, prostaglandin E2 (PGE2), tumor necrosis factor (TNF)-α, and interleukin (IL)-17 in the sera of CIA mice were measured. Histopathological changes in the ankle joints of CIA mice were also analyzed by staining with hematoxylin and eosin (H and E), safranin-O and immunohistochemistry using anti-TNF-α and anti-IL-17 antibodies. The arthritic score was increased in CIA mice in a time-dependent manner, as were the serum levels of anti-ColII IgG2a antibody, PGE2, TNF-α, and IL-17. However, the oral administration of PC extract at 50 and 100 mg\u002Fkg in CIA mice significantly decreased the arthritic scores, and the serum levels of anti-ColII IgG2a, PGE2, TNF-α, and IL-17 compared with those in the CIA group (P\u003C0.05 or P\u003C0.01). Furthermore, histopathological improvement of the joint architecture in CIA mice was observed after administration of PC extract. PC extract also significantly inhibited the expression of TNF-α and IL-17 in the joints of CIA mice by suppressing the expression of their mRNA and proteins. PC extract may improve the pathological progression of RA through the inhibition of joint destruction by synovial inflammation and immune-stimulation, therefore, it would be a potential anti-arthritic agent in RA.",{"EN":436},"Inhibitory effect of the extract of Phellodendron amurense ruprecht root on collagen-induced arthritis in 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Immunopathogenesis of collagen arthritis. Springer Sem Immunopathol 2003;25:3–18.","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00281-003-0127-1",{"doi":572},"10.1007\u002Fs00281-003-0127-1",{"id":574,"text":575,"url":576,"identifiers":577},"4c68646b-0035-4279-8000-0006b275d4fa","Chabaud M, Durand JM, Buchs N, Fossiez F, Page G, Frappart L, et al. Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum 1999;42:963–970.","https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs10440-022-00541-7",{"doi":578},"10.1007\u002Fs10440-022-00541-7",{"id":574,"text":580,"url":576,"identifiers":581},"McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 2007;7:429–442.",{"doi":578},{"id":574,"text":583,"url":576,"identifiers":584},"Gao XZ, Komai-Koma M, Leung BP, Howe HS, McSharry C, McInnes IB, et al. Resveratrol modulates murine collageninduced arthritis by inhibiting Th17 and B-cell function. Ann Rheum Dis 2012;71:129–135.",{"doi":578},{"id":586,"text":587,"url":588,"identifiers":589},"cbdc84e8-cb9f-490c-a222-f38a1705901b","Efthimiou P, Kukar M. Complementary and alternative medicine use in rheumatoid arthritis: proposed mechanism of action and efficacy of commonly used modalities. Rheumatol Int 2010;30:571–586.","http:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs00296-009-1206-y",{"doi":590},"10.1007\u002Fs00296-009-1206-y",{"id":574,"text":592,"url":576,"identifiers":593},"Callahan LF, Wiley-Exley EK, Mielenz TJ, Brady TJ, Xiao C, Currey SS, et al. Use of complementary and alternative medicine among patients with arthritis. Prevent Chronic Dis 2004;6:A44.",{"doi":578},{"id":22,"text":595,"url":22,"identifiers":596},"Yen CH, ed. The pharmacology of Chinese herbs. 1st ed. Taipei: Chin-Yin Publishing;1999:376–377.",{},{"id":574,"text":598,"url":576,"identifiers":599},"Zhang Q, Zhang Q, Cai L, Zhong G, Luo W. Simultaneous determination of jatrorrhizine, palmatine, berberine, and obacunone in Phellodendri Amurensis Cortex by PR-HPLC. China J Chin Mater Med (Chin) 2010;35:2061–2064.",{"doi":578},{"id":574,"text":601,"url":576,"identifiers":602},"Uchuyama T, Kamikawa H, Ogita Z. Anti-ulcer effect of extract from Phellodendri cortex. J Pharm Sco Jap (Jpn) 1989;109:672–676.",{"doi":578},{"id":604,"text":605,"url":606,"identifiers":607},"b9ee6164-f26c-42aa-9365-36cee725ba83","Park JI, Shim JK, Do JW, Kim SY, Seo EK, Kwon HJ, et al. Immune-stimulating properties of polysaccharides from Phellodendri cortex (Hwangbek). Glycoconj J 1999;16:247–252.","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1023\u002FA:1007084506071",{"doi":608},"10.1023\u002FA:1007084506071",{"id":22,"text":610,"url":22,"identifiers":611},"Kong LD, Yang C, Qiu X, Wu HP, Ye DJ. Effects of different processing products of Cortex Phellodendri on scavenging oxygen free radicals and anti-lipidperoxidation. China J Chin Mater Med (Chin) 2001;26:245–248.",{},{"id":574,"text":613,"url":576,"identifiers":614},"Park YK, Chung YS, Kim YS, Kwon OY, Joh TH. Inhibition of gene expression and production of iNOS and TNF-alpha in LPS-stimulated microglia by methanol extract of Phellodendri cortex. Int Immunopharmacol 2007;7:955–962.",{"doi":578},{"id":574,"text":616,"url":576,"identifiers":617},"Wu YH, Chuang SY, Hong WC, Lai YJ, Chang YL, Pang JH. In vivo and in vitro inhibitory effects of a traditional Chinese formulation on LPS-stimulated leukocyte-endothelial cell adhesion and VCAM-1 gene expression. J Ethnopharmacol 2012;140:55–63.",{"doi":578},{"id":574,"text":619,"url":576,"identifiers":620},"Mao YF, Li YQ, Zong L, You XM, Lin FQ, Jiang L. Methanol extract of Phellodendri cortex alleviates lipopolysaccharideinduced acute airway inflammation in mice. Immunopharmacol Immunotoxicol 2010;32:110–115.",{"doi":578},{"id":574,"text":622,"url":576,"identifiers":623},"Xian YF, Mao QQ, Ip SP, Lin ZX, Che CT. Comparison on the anti-nflammatory effect of Cortex Phellodendri Chinensis and Cortex Phemmodendri Amurensis in 12-O-tetradecanoyl-phorbol-13-acetate-induced ear edema in mice. J Ethnopharmacol 2011;137:1425–1430.",{"doi":578},{"id":574,"text":625,"url":576,"identifiers":626},"Hong SJ, Fong JC, Hwang JH. Effects of crude drugs on glucose uptake in 3T3-L1 adipocytes. Kaohsiung J Med Sci 2000;16:445–451.",{"doi":578},{"id":574,"text":628,"url":576,"identifiers":629},"Kim HJ, Kong MK, Kim YC. Beneficial effects of Phellodendri Cortex extract on hyperglycemia and diabetic nephropathy in streptozotocin-induced diabetic rats. BMB Rep 2008;41:710–715.",{"doi":578},{"id":574,"text":631,"url":576,"identifiers":632},"Jung HW, Jin GZ, Kim SY, Kim YS, Park YK. Neuroprotective effect of methanol extract of Phellodendri cortex against 1-methyl-4-penylpyridinium (MPP+)-induced apoptosis in PC12 cells. Cell Biol Int 2009;33:957–963.",{"doi":578},{"id":634,"text":635,"url":636,"identifiers":637},"840cf8f1-5dc2-4942-ad32-0d88b81f1cf4","Cho YG, Cho ML, Min SY, Kim HY. Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis. Autoimm Rev 2007;7:65–70.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS1568997207001164",{"doi":638},"10.1016\u002Fj.autrev.2007.08.001",{"id":22,"text":640,"url":22,"identifiers":641},"Stuart JM, Cremer MA, Kang AH, Townes AS. Collageninduced arthritis in rats: evaluation of early immunologic events. Arthritis Rheum 1979;22:1344–1351.",{},{"id":574,"text":643,"url":576,"identifiers":644},"Brand DD, Latham KA, Rosloniec EF. Collagen-induced arthritis as a model for rheumatoid arthritis. Nature Protocols 2007;2:1269–1275.",{"doi":578},{"id":574,"text":646,"url":576,"identifiers":647},"Ahmed S, Anuntiyo J, Malemud CJ, Haqqi TM. Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: a review. Evid Based Complement Alternat Med 2005;2:301–308.",{"doi":578},{"id":574,"text":649,"url":576,"identifiers":650},"Ahmed M, Khanna D, Furst DE. Meloxicam in rheumatoid arthritis. Expert Opin Drug Metab Toxicol 2005;1:739–751.",{"doi":578},{"id":574,"text":652,"url":576,"identifiers":653},"Fournier C. Where do T cells stand in rheumatoid arthritis? Joint Bone Spine 2005;72:527–532.",{"doi":578},{"id":655,"text":656,"url":657,"identifiers":658},"d15ac860-f5b2-4bb8-bcb9-ad78cf73358f","Martel-Pelletier J, Pelletier JP, Fahmi H. Cyclooxygenase-2 and prostaglandins in articular tissues. Semin Arthritis Rheum 2003;33:155–167.","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0049017203001343",{"doi":659},"10.1016\u002Fs0049-0172(03)00134-3",{"id":574,"text":661,"url":576,"identifiers":662},"Smolen JS, Redlich K, Zwerina J, Aletaha D, Steiner G, Schett G. Pro-inflammatory cytokines in rheumatoid arthritis: pathogenetic and therapeutic aspects. Clinic Rev Allergy Immunol 2005;28:239–248.",{"doi":578},{"id":574,"text":664,"url":576,"identifiers":665},"Astry B, Harberts E, Moudgil KD. A cytokine-centric view of the pathogenesis and treatment of autoimmune arthritis. J Interferon Cytokine Res 2011;31:927–940.",{"doi":578},{"id":574,"text":667,"url":576,"identifiers":668},"Stamp LK, James MJ, Cleland LG. Interleukin-17: the missing link between T-cell accumulation and effector cell actions in rheumatoid arthritis. Immunol Cell Biol 2004;82:1–9.",{"doi":578},{"id":574,"text":670,"url":576,"identifiers":671},"Arend WP, Dayer JM. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis. Arthritis Rheum1995;38:151–160.",{"doi":578},{"id":574,"text":673,"url":576,"identifiers":674},"Venkatesha SH, Berman BM, Moudgil KD. Herbal medicinal products target defined biochemical and molecular mediators of inflammatory autoimmune arthritis. Bioorg Med Chem 2011;19:21–29.",{"doi":578},{"id":574,"text":676,"url":576,"identifiers":677},"Schnotzer TJ, Hochberg MC. COX-2-selective inhibitors in the treatment of arthritis. Clevelend Clin J Med 2002;69:SI20–S130.",{"doi":578},{"id":574,"text":679,"url":576,"identifiers":680},"Wang XH, Jiang SM, Sun QW. Effects of berberine on human arthritis fibroblast-like synoviocytes. Exp Biol Med (Maywood) 2011;236:859–866.",{"doi":578},{"id":574,"text":682,"url":576,"identifiers":683},"Hu Z, Jiao Q, Ding J, Liu F, Liu R, Shan L, et al. Berberine induces dendritic cell apoptosis and has therapeutic potential for rheumatoid arthritis. Arthritis Rheum 2011;63:949–959.",{"doi":578},{"id":685,"createTime":686,"updateTime":687,"relativeEntities":688,"slug":689,"properties":690,"entityType":125,"verifyStatus":126,"verifyTime":701,"verifyNote":128,"languages":22,"translateLanguages":22,"viewCount":23,"primaryUrl":702,"fullTextUrl":22,"authors":703,"publicationType":164,"publisherRelationship":732,"citationCount":788,"citationInfo":789,"publishDate":792,"publishYear":790,"citationAnalyzeStatus":21,"lastCitationAnalyze":793,"indexDatabases":794,"openAccess":22,"references":22,"isForceReanalyzing":229},"5ced279e-d4e8-4ecf-80e3-9e8fe0f94dca","2023-12-06T10:46:32.356+00:00","2026-07-27T16:09:29.774+00:00",[],"Comparative-observation-on-the-effects-of-Radix-Tripterygium-hypoglaucum-tablet-and-Tripterygium-glycosides-tablet-in-treating-erosive-oral-lichen-planus",{"abstract":691,"title":693,"gsPaper":695,"references":697,"doi":699},{"EN":692},"\n                Objective: To compare the therapeutic effects of Radix Tripterygium hypoglaucum tablet (THT) and Tripterygium glycosides tablet (TGT) in treating erosive oral lichen planus(EOLP).Methods: The patients were randomized into two groups, and they were treated with THT (n = 47) or TGT (n = 47), respectively. The therapeutic effects were evaluated after 3 months treatment.Results: For the patients of grade 1, the total efficacy in TGT group was 85. 71%, compared with 52. 38% in THT group, the efficacy was statistically greater in the group receiving TGT (P = 0.043). However, for the patients of grade 2, the difference was not statistically significant (P = 0.173).Conclusion: TGT is more effective in treating EOLP than THT for grade 1 patients. However, TGT is not suitable for patients of child bearing age.",{"EN":694},"Comparative observation on the effects of Radix Tripterygium hypoglaucum tablet and Tripterygium glycosides tablet in treating erosive oral lichen planus",{"VOID":696},"[\"4603896316633394844\"]",{"VOID":698},"Li BQ editor. Periodontal diseases. Beijing: People’s Medical Publishing House, 2000: 86–88.\nXie BG, Zhong W, Meng SL. Clinical investigation on the side effect of Tripterygium glycosides tablet. Guangxi Med J 2002; 24(4): 576.\nFan XZ, Chen Y, Li XD. Investigation of adverse reaction caused by Tripterygium wifordii Hook, f in patients with immune disease. Chin J Integr Tradit West Nephrol 2001; 2(2): 83.\nWu XL, Li JB, Mo SL, et al. Clinical investigation on Colquhounia Root Tablet in treating liquid metabolism disturbance secondary to nephrotic syndrome. Chin J Integr Tradit West Med 2002; 22(1): 30.\nLiu Y, Guan JH. Clinical observation of Radix Tripterygium Hypoglaucum Tablet in treating refractory nephrotic syndrome. 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Xia",{"url":809,"publisher":894,"properties":944},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":895,"slug":10,"properties":896,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":900,"manageAffiliations":913,"indexDatabases":924,"url":22,"thumbnailPath":22,"statistic":939,"gsStatistic":22,"type":103,"analyzePriority":22},[],{"issn":897,"title":898,"eissn":899},{"VOID":15},{"EN":17},{"VOID":13},[901,905,909],{"id":26,"createTime":22,"updateTime":22,"relativeEntities":902,"label":903,"description":904,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":29},{},{"id":32,"createTime":22,"updateTime":22,"relativeEntities":906,"label":907,"description":908,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":35},{},{"id":38,"createTime":22,"updateTime":22,"relativeEntities":910,"label":911,"description":912,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":41},{},[914,919],{"id":45,"createTime":22,"updateTime":22,"relativeEntities":915,"slug":22,"properties":916,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":918,"statistic":22},[],{"title":917},{"EN":49},[],{"id":52,"createTime":22,"updateTime":22,"relativeEntities":920,"slug":22,"properties":921,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":923,"statistic":22},[],{"title":922},{"EN":56},[],[925,932],{"id":60,"indexDatabase":926,"url":71,"indexYears":72,"academicFieldIds":931,"indexDatabaseRanking":22},{"id":62,"createTime":22,"updateTime":22,"relativeEntities":927,"label":928,"description":929,"key":68,"publicationTags":930,"standard":22},[],{"EN":65,"VI":65},{"EN":65,"VI":67},[70],[74,75,76],{"id":78,"indexDatabase":933,"url":91,"indexYears":22,"academicFieldIds":938,"indexDatabaseRanking":22},{"id":80,"createTime":22,"updateTime":22,"relativeEntities":934,"label":935,"description":936,"key":87,"publicationTags":937,"standard":22},[],{"EN":83,"VI":83},{"EN":85,"VI":86},[89,90],[93],{"impactFactor":23,"impactFactorByYear":940,"i10Index":23,"i10IndexLast5Year":23,"totalPublication":96,"totalPublicationByYear":941,"totalCitation":23,"totalCitationByYear":942,"totalCitationPerPublication":23,"totalCitationPerPublicationByYear":943,"hindexLast5Year":23,"hindex":23},{},{"1995":98,"1996":98,"1997":99,"2000":98,"2001":98,"2002":100},{},{},{"pages":945,"volume":947},{"VOID":946},"200-200",{"VOID":948},"4","1998-09-01",1998,"2026-07-27T09:38:45.764+00:00",[89],{"id":954,"createTime":955,"updateTime":956,"relativeEntities":957,"slug":958,"properties":959,"entityType":125,"verifyStatus":126,"verifyTime":970,"verifyNote":128,"languages":22,"translateLanguages":22,"viewCount":23,"primaryUrl":971,"fullTextUrl":22,"authors":972,"publicationType":164,"publisherRelationship":1042,"citationCount":22,"citationInfo":22,"publishDate":1098,"publishYear":1099,"citationAnalyzeStatus":563,"lastCitationAnalyze":956,"indexDatabases":1100,"openAccess":22,"references":22,"isForceReanalyzing":229},"ad4a692a-4256-44d4-8158-7da5ea04e53a","2023-12-28T06:37:27.700+00:00","2026-07-25T10:50:21.283+00:00",[],"Clinical-study-on-effect-of-Chinese-herbal-medicine-for-supplementing-kidney-and-Qi-and-activating-blood-circulation-in-treating-intrauterine-growth-retardation-of-fetus",{"abstract":960,"title":962,"gsPaper":964,"references":966,"doi":968},{"EN":961},"Objective: To explore the therapeutic effect and the possible working mechanism in using Chinese herbal medicine (CHM) for supplementing Kidney and Qi, and activating blood circulation in treating intrauterine growth retardation of fetus (IUGR). Methods: Fifty-five cases of IUGR were divided into two groups, 30 cases in the CHM group treated with CHM and the 25 in the control group treated with amino acids. The effect of CHM treatment was observed and compared with that of the control group, normal pregnancy group and non-treated IUGR group. Results: Body weight of the newborns in the CHM was markedly higher than that in the control group. Not only the maternal fundal height (FH) and the abdominal circumference (AC), but also the fetal growth parameters, including biparietal diameter, head circumference (HC), and femur length (FL) in the CHM group increased much faster than those in the control group. After CHM treatment, the maternal serum levels of estriol (E3) and human placental lactogen (hPL) approached to those in the normal pregnancy group, but the control group, in comparison with the normal pregnancy group, was significantly different. The umbilical venous plasma concentration of essential amino acids in both treated groups improved, but the improvement in the CHM group was more significant than that in the control group. No apparent adverse effect of CHM was observed in either mother or fetus. Conclusion: CHM for supplementing Kidney and Qi and activating blood circulation was more effective in improving placental function and enhancing amino acid transportation than amino acid.",{"EN":963},"Clinical study on effect of Chinese herbal medicine for supplementing kidney and Qi and activating blood circulation in treating intrauterine growth retardation of fetus",{"VOID":965},"[\"9969519336424583299\"]",{"VOID":967},"Li Yuling, SHU Huying, YE Wangyun, et al. Experimental study on effect of Huoxue Huayu recipe in preventing and treating asymmetrical fetal growth retardation. CJIM 1988:8(10):611–613.\nJiang Zongben. Practical Handbook of Gynecology and Obstetrics. Beijing: The People’s Army Medical Press, 1996:173–174.\nWang Zehua, LI Weiji, XIAO Jianguo, et al. Analysis of the distribution and contributing factors of Wuhan area newborn birth weights. J Wuhan Med 1991; 15(4): 219–220.\nSu Li, LEI Huizhong, YU Huanzhen, et al. A comparison of plasma amino acid concentration between appropriate and small for gestational age fetus. Chin J Obstet Gynecol 1996:31(2):93–96.\nCetin I, Ronzoni S, Marconi AM, et al. Maternal concentrations and fetal-maternal concentration differences of plasma amino acids in normal and intrauterine growth restricted pregnancies. Am J Obstet Gynecol 1996; 174(5): 1575–1583.\nZhang Xiuquan, YAN Juanhong, HONG Suying, et al. Experimental study on the treatment of fetal rabbits with intrauterine growth retardation. Chin J Obstet Gynecol 1996;31(2):97–99.\nJiang Yong, SHU Huying, YE Wangyun, et al. The mechanism study of Huoxue Huayu Recipe in preventing and treating asymmetrical fetal growth retardation. CJIM 1990;10(3): 157–159.\nHuang Guangying, Han Qinghong, XU Min, et al. Experimental study of the effect of Bushen Yiqi Huoxue Recipe on Na+-K+-ATPase, Ca2+-Mg2+-ATPase of ery-throcytes membrane in pregnant intrauterine growth retardation mice. CJIM 1998; (supplement):346–348.",{"VOID":969},"10.1007\u002FBF02970570","2024-06-25T00:10:33.865+00:00","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002FBF02970570",[973,988,1001,1014,1029],{"id":974,"sortIndex":23,"researcher":22,"roles":975,"affiliations":976,"properties":985,"displayName":987,"givenName":22,"familyName":22},"2247d858-0ded-426b-958c-d2fb40e74b09",[134],[977],{"id":978,"sortIndex":23,"affiliation":979,"properties":22},"d87444d1-1d75-43ef-899c-e450ab7493ee",{"id":978,"createTime":22,"updateTime":22,"relativeEntities":980,"slug":22,"properties":981,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":984,"statistic":22},[],{"title":982},{"VI":983},"Institute of Integrated Traditional Chinese and Western Medicine, Affiliated Tongji Hospital, Tongji Medical University, Wuhan",[],{"title":986},{"VI":987},"Guangying Huang",{"id":989,"sortIndex":98,"researcher":22,"roles":990,"affiliations":991,"properties":998,"displayName":1000,"givenName":22,"familyName":22},"2f89c51f-4152-4467-b205-5f1098b04ddf",[134],[992],{"id":978,"sortIndex":23,"affiliation":993,"properties":22},{"id":978,"createTime":22,"updateTime":22,"relativeEntities":994,"slug":22,"properties":995,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":997,"statistic":22},[],{"title":996},{"VI":983},[],{"title":999},{"VI":1000},"Yiming Shu",{"id":1002,"sortIndex":99,"researcher":22,"roles":1003,"affiliations":1004,"properties":1011,"displayName":1013,"givenName":22,"familyName":22},"b4896f3b-05d4-41a9-bd24-a982447258e3",[134],[1005],{"id":978,"sortIndex":23,"affiliation":1006,"properties":22},{"id":978,"createTime":22,"updateTime":22,"relativeEntities":1007,"slug":22,"properties":1008,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1010,"statistic":22},[],{"title":1009},{"VI":983},[],{"title":1012},{"VI":1013},"Wangyun 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Yuan",{"id":1030,"sortIndex":310,"researcher":22,"roles":1031,"affiliations":1032,"properties":1039,"displayName":1041,"givenName":22,"familyName":22},"96ecbc95-22e8-4ba2-974b-6b49cd071e7e",[134],[1033],{"id":1019,"sortIndex":23,"affiliation":1034,"properties":22},{"id":1019,"createTime":22,"updateTime":22,"relativeEntities":1035,"slug":22,"properties":1036,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1038,"statistic":22},[],{"title":1037},{"VI":1024},[],{"title":1040},{"VI":1041},"Fuyuan Qiao",{"url":971,"publisher":1043,"properties":1093},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1044,"slug":10,"properties":1045,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":1049,"manageAffiliations":1062,"indexDatabases":1073,"url":22,"thumbnailPath":22,"statistic":1088,"gsStatistic":22,"type":103,"analyzePriority":22},[],{"issn":1046,"title":1047,"eissn":1048},{"VOID":15},{"EN":17},{"VOID":13},[1050,1054,1058],{"id":26,"createTime":22,"updateTime":22,"relativeEntities":1051,"label":1052,"description":1053,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":29},{},{"id":32,"createTime":22,"updateTime":22,"relativeEntities":1055,"label":1056,"description":1057,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":35},{},{"id":38,"createTime":22,"updateTime":22,"relativeEntities":1059,"label":1060,"description":1061,"parentId":22,"standard":22,"scholarHubFieldId":22},[],{"EN":41},{},[1063,1068],{"id":45,"createTime":22,"updateTime":22,"relativeEntities":1064,"slug":22,"properties":1065,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1067,"statistic":22},[],{"title":1066},{"EN":49},[],{"id":52,"createTime":22,"updateTime":22,"relativeEntities":1069,"slug":22,"properties":1070,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1072,"statistic":22},[],{"title":1071},{"EN":56},[],[1074,1081],{"id":60,"indexDatabase":1075,"url":71,"indexYears":72,"academicFieldIds":1080,"indexDatabaseRanking":22},{"id":62,"createTime":22,"updateTime":22,"relativeEntities":1076,"label":1077,"description":1078,"key":68,"publicationTags":1079,"standard":22},[],{"EN":65,"VI":65},{"EN":65,"VI":67},[70],[74,75,76],{"id":78,"indexDatabase":1082,"url":91,"indexYears":22,"academicFieldIds":1087,"indexDatabaseRanking":22},{"id":80,"createTime":22,"updateTime":22,"relativeEntities":1083,"label":1084,"description":1085,"key":87,"publicationTags":1086,"standard":22},[],{"EN":83,"VI":83},{"EN":85,"VI":86},[89,90],[93],{"impactFactor":23,"impactFactorByYear":1089,"i10Index":23,"i10IndexLast5Year":23,"totalPublication":96,"totalPublicationByYear":1090,"totalCitation":23,"totalCitationByYear":1091,"totalCitationPerPublication":23,"totalCitationPerPublicationByYear":1092,"hindexLast5Year":23,"hindex":23},{},{"1995":98,"1996":98,"1997":99,"2000":98,"2001":98,"2002":100},{},{},{"pages":1094,"volume":1096},{"VOID":1095},"91-95",{"VOID":1097},"6","2000-06-01",2000,[70,89],{"id":1102,"createTime":1103,"updateTime":1104,"relativeEntities":1105,"slug":1106,"properties":1107,"entityType":125,"verifyStatus":126,"verifyTime":1118,"verifyNote":128,"languages":22,"translateLanguages":22,"viewCount":23,"primaryUrl":1119,"fullTextUrl":22,"authors":1120,"publicationType":164,"publisherRelationship":1227,"citationCount":22,"citationInfo":22,"publishDate":1283,"publishYear":1284,"citationAnalyzeStatus":1285,"lastCitationAnalyze":1286,"indexDatabases":1287,"openAccess":22,"references":22,"isForceReanalyzing":229},"53213eba-2eb1-4bff-815c-04802335c95c","2023-12-31T04:58:56.419+00:00","2026-07-22T21:52:37.747+00:00",[],"Research-Progress-of-Angiogenesis-in-Atherosclerotic-Plaque-in-Chinese-Medicine-and-Western-Medicine",{"abstract":1108,"title":1110,"gsPaper":1112,"references":1114,"doi":1116},{"EN":1109},"Angiogenesis in atherosclerotic plaque plays a critical role in the mechanism of atherosclerotic physiopathology. Present consensus shows that angiogenesis in atherosclerotic plaque is mainly resulted in hypoxia, inflammation and some pro-angiogenic factors. The homeostasis in plaque, which is hypoxic and infiltrated by inflammatory cells, may lead to angiogenesis, increase the plaque instability and the incidence rate of vascular events. This article reviews the progression of pathogenetic mechanism, physiopathological significance, relevant detecting technique and corresponding therapeutic methods of Chinese and Western medicine of angiogenesis in atherosclerotic plaque, so as to provide more theoretical basis for atherosclerotic clinical treatment.",{"EN":1111},"Research Progress of Angiogenesis in Atherosclerotic Plaque in Chinese Medicine and Western Medicine",{"VOID":1113},"[]",{"VOID":1115},"Potente M, Gerhardt H, Garmeliet P. Basic and therapeutic aspects of angiogenesis. Cell 2011;146:873–887.\nChistiakov DA, Orekov AN, Bobryshev YV. Contribution of neovascularization and intraplaque hemorrhage to atherosclerotic plaque progression and instability. Actaphysiol (Oxf) 2015;213:539–553.\nAsahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275:965–967.\nRisau W. Mechanism of angiogenesis. Nature 1997;386:671–674.\nGao C, Yan XY, Zhuo W, Zhu B, Zhou TH. The progress of embryonic angiogenesis. Chin J Cell Bio (Chin) 2015;37:720–727.\nWang Y, Gabrielsen A, Lawler PR, Paulsson-Berne G, Steinbruchel DA, Hansson GK, et al. Myocardial gene expression of angiogenic factors in human chronic ischemic myocardium influence of acute ischemia\u002Fcardioplegia and reperfusion. Microcirculation 2006;13:187–197.\nBahadori B, Uitz E, Mayer A, Harauer J, Dam K, Truschnig-Wilders M, et al. Polymorphisms of the hypoxia-inducible factor I gene and peripheral artery disease. Vasc Med 2010;15:371–374.\nWihastuti TA, Sargowo D, Tjokroprawiro A, Permatasari N, Widodo MA4, Soeharto S. Vasavasorum antiangiogenesis through H2O2, HIF-1α, NF-kB, and iNOS inhibition by mangosteen pericarp ethanolic extract (Garcinia mangostana Linn) in hypercholesterol-dict-given Rattus norvegieus Wistar strain. Vasc Health Risk Manag 2014;10:523–531.\nWinnik S, Lohmann C, Siciliani G, von Lukowicz T, Kuschnerus K, Kraenkel N, et al. Systemic VEGF inhibition accelerates experimental atherosclerosis and disrupts endothelial homeostasis–implications for cardiovascular safety. Int J Cardiol 2013;168:2453–2461.\nNidorf SM, Eikelboom JW, Budgon CA, Thompson PL. Lowdose colchicine for secondary prevention of cardiovascular disease. Am Coll Cardiol 2013;61:404–410.\nGray SP, Di Marco E, Kennedy K, Chew P, Okabe J, El-Osta A, et al. Reactive oxygen species can provide atheroprotection via NOX4-dependent inhibition of inflammation and vascular remodeling. Arterioscler Thromb Vasc Biol 2016;36:295–307.\nKim YW, West XZ, Byzova TV. Inflammation and oxidative stress in angiogenesis and vascular disease. J Mol Med (Berl) 2013;91:323–328.\nTaqueti VR, Di Carli MF, Jerosch-Herold M, Sukhova GK, Murthy VL, Folco EJ, et al. Increased microvascularization and vessel permeability associated with active inflammation in human atheromata. Circ Cardiovasc Imag 2014;7:920–929.\nLim HN, Jang JP, Han JM, Jang JH, Ahn JS, Jung HJ. Antiangiogenic potential of microbial metabolite elaiophylin for targeting tumor angiogenesis. Molecules 2018;23:563.\nRiquelme JA, Westermeier F, Hall AR, Vicencio JM, Pedrozo Z, Ibacache M, et al. Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS\u002FNO dependent mechanism. Pharmacol Res 2016;103:318–327.\nEverett BM, Pradhan AD, Solomon DH, Paynter N, Macfadyen J, Zaharris E, et al. Rationale and design of the cardiovascular inflammation reduction trial: a test of the inflammatory hypothesis of atherothrombosis. Am Heart J 2013;166:199–207.\nLu Q, Yao Y, Hu Z, Hu C, Song Q, Ye J, et al. Angiogenic factor AGGF1 activates autophagy with an essential role in therapeutic angiogenesis for heart disease. PLoS Biol 2016;14:e1002529.\nKorhonen EA, Lampinen A, Giri H, Anisimov A, Kim M, Allen B, et al. Tie1 controls angiopoietin function in vascular remodeling and inflammation. J Clin Invest 2016;126:3495–3510.\nYoung CC, Al-Dalahmah O, Lewis NJ, Brooks KJ, Jenkins MM, Poirier F, et al. Blocked angiogenesis in Galectin-3 null mice does not alter cellular and behavioral recovery after middle cerebral artery occlusion stroke. Neurobiol Dis 2014;63:155–164.\nHanzawa H, Sakamoto T, Kaneko A, Manri N, Zhao Y, Zhao S, et al. Combined plasma and tissue proteomic study of atherogenic model mouse: approach to elucidate molecular determinants in atherosclerosis development. J Proteome Res 2015;14:4257–4269.\nde Vries MR, Quax PH. Plaque angiogenesis and its relation to inflammation and atherosclerotic plaque destabilization. Curr Opin Lipidol 2016;27:499–506.\nGuo Y, Zhang C, Wu X. The value of SMI in detection of carotid artery plaque neovascularization. J Chin Clin Med Imag (Chin) 2016;6:400–402.\nYe YQ, Xue HY, Gao Li, Sun Li, LI L, Xing YY, Chen JJ. Superb microvascular imaing in neovascularization within carotid plagues: compared with contract enhanced ultrasound. Chin J Imag Technol (Chin) 2015;31:651–653.\nPalekar RU, Jallouk AP, Myerson JW, Pan H, Wickline SA. Inhibition of thrombin with PPACK-nanoparticles restores disrupted endothelial barriers and attenuates thrombotic risk in experimental atherosclerosis. Arterioscler Thromb Vasc Biol 2016;36:446–455.\nKhan R, Spagnoli V, Tardif JC, L'Allier PL. Novel antiinflammatory therapies for the treatment of atherosclerosis. Atherosclerosis 2015;18:497–509.\nMartinez GJ, Robertson S, Barraclough J, Xia Q, Mallat Z, Bursill C. Colchicine acutely suppresses local cardiac production of inflammatory cytokines in patients with an acute coronary syndrome. J Am Heart Assoc 2015;4:e002128.\nByon CH, Han T, Wu J, Hui ST. Txnip ablation reduces vascular smooth muscle cell inflammation and ameliorates atherosclerosis in apolipoprotein E knockout mice. Atherosclerosis 2015;241:313–321.\nRidker PM, Thuren T, Zalewski A, Libby P. Interleukin-1ß inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Antiinflammatory Thrombosis Outcomes Study (CANTOS). Am Heart J 2011;162:597–605.\nTykhomyrov AA, Nedzvetsky VS, Bardachenko NI, Grinenko TV, Kuryata OV. Statin treatment decreases serum angiostatin levels in patients with ischemic heart disease. Life Sci 2015;134:22–29.\nVincent L, Chen W, Hong L, Mirshahi F, Mishal Z, Mirshahi-Khorassani T, et al. Inhibition of endothelial cellmigration by cerivastatin, an HMG-CoA reductase inhibitor: contribution to its anti-angiogenic effect. FEBS Lett 2001;495:159–166.\nLi Y, Zhu Y, Deng Y, Liu Y, Mao Y, Wang J, et al. The therapeutic effect of bevacizumab on plaque neovascularization in a rabbit model of atherosclerosis during contrast-enhanced ultrasonography. Sci Rep 2016;6:304–317.\nHu FY, Wu C, Li Y, Xu K, Wang WJ, Cao H, et al. AGGF1 is a novel anti-inflammatory factor associated with TNF-a-induced endothelial activation. Cell Signal 2013;25:1645–1653.\nQiao Y, Zhang PJ, Lu XT, Sun WW, Liu GL, Ren M, et al. Panax notoginseng saponins inhibits atherosclerotic plaque angiogenesis by down-regulating vascular endothelial growth factor and nicotinamide adenine dinucleotide phosphate oxidase subunit 4 expression. Chin J Integr Med 2015;21:259–265.\nWu M, Zhang WG, Liu LT. Red yeast rice prevents atherosclerosis through regulating inflammatory signaling pathways. Chin J Integr Med 2017;23:689–695.\nXie Y, Zhang J, Zhong A, Wang A, Tian L. Discussion on staging treatment of carotid atherosclerosis based on phlegm stagnation. Chin J Tradit Chin Med Pharm (Chin) 2017;32:101–104.\nTao L, Wang S, Zhao Y, Wang AY, Zhang L, Ruan JS. Pleiotropic effects of herbs characterized with bloodactivating and stasis-resolving functions on angiogenesis. Chin J Integr Med 2016;22:795–800.\nChen Q, Zhuang Q, Mao W, Xu XM, Wang LH, Wang HB. Inhibitory effect of cryptotanshinone on angiogenesis and Wnt\u002Fß-catenin signaling pathway in human umbilical vein endothelial cells. Chin J Integr Med 2014;20:743–50.\nZhou H, Zhang J. Theoretical exploration of replenishing Kidney and strengthening Spleen and eliminating phlegm and dissipating accumulation method in prevention and treatment of atherosclerosis RUAN shiy. Chin Archives Tradit Chin Med (Chin) 2016;34:10–13.\nZhu B, Li Q. Tips of treating atherosclerosis from phlegm stasis. Guide China Med (Chin) 2015;13:196–198.\nLiu W, He J. The effect of Yishen Huoxue Jiedu Decotion on CD36 expression and CD40\u002Fcd40L pathway in early atherosclerosis rabbits. Clin J Tradit Chin Med (Chin) 2016;3:424–428.\nMei Y. Yang weak and yin-qi deficiency and blood stasisreplenish qi and activate blood circulation-coronary heart disease. J Practic Tradit Chin Inter Med (Chin) 2015;29:79–81.",{"VOID":1117},"10.1007\u002Fs11655-018-2569-2","2024-06-25T14:04:54.772+00:00","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs11655-018-2569-2",[1121,1136,1149,1162,1175,1188,1201,1214],{"id":1122,"sortIndex":23,"researcher":22,"roles":1123,"affiliations":1124,"properties":1133,"displayName":1135,"givenName":22,"familyName":22},"e5e03aab-9d44-49cb-99e3-acbe04f1b014",[134],[1125],{"id":1126,"sortIndex":23,"affiliation":1127,"properties":22},"53aa265b-3b5d-4bea-98d9-abb2fc48645e",{"id":1126,"createTime":22,"updateTime":22,"relativeEntities":1128,"slug":22,"properties":1129,"entityType":22,"verifyStatus":22,"verifyTime":22,"verifyNote":22,"languages":22,"translateLanguages":22,"viewCount":22,"url":22,"parentIds":1132,"statistic":22},[],{"title":1130},{"VI":1131},"The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China",[],{"title":1134},{"VI":1135},"Lan 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explore the antitumor effects of ethanol extract from Ventilago leiocarpa Benth (EEVLB) on sarcoma 180 (S180) tumor-bearing mice and the potential mechanism. Sixty mice were randomly assigned to 6 groups according to a random number table: normal group, model group, 5-fluorouracil (5-FU) group (0.02 g·kg−1), and high-, medium-, low-dose EEVLB groups (100, 84, and 56 g of raw material·kg−1 body weight, respectively), with 10 mice each group. All treatments were given once daily for 10 consecutive days. Effects of EEVLB on inhibiting tumor growth and immune function in mice were evaluated among all groups after the treatments by detecting tumor inhibition rate, organ index, serum levels of interleukin (IL)-2, -6, -10, CD3+CD4+ T lymphocytes, CD4+\u002FCD8+ ratio, caspase-3 and Bcl-2. EEVLB with different concentrations achieved inhibition of tumor growth in vivo, wherein the high-dose group showed the most significant reduction in tumor weight and increased apoptosis of tumor cells (P\u003C0.05). In addition, both net weight gain and spleen index of mice showed uptrend in EEVLB treatment groups (P\u003C0.05). Besides, serum levels of IL-2 and IL-6, percentages of CD3+CD4+ T lymphocytes and ratio of CD4+\u002FCD8+ in peripheral blood were elevated in high- and medium-dose EEVLB groups compared with the model group (P\u003C0.05). Also, upregulation of caspase-3 and downregulation of Bcl-2 were observed at protein levels in the high-dose EEVLB group (P\u003C0.01). EEVLB exhibits promising antitumor activity in vivo. This effect might be due to activation of apoptotic signaling pathway, increase of cytokine levels and enhancement of immune function in tumor-bearing mice.",{"EN":1298},"Antitumor Effects of Ethanol Extract from Ventilago leiocarpa Benth on Sarcoma 180 Tumor-Bearing Mice and Possible Immune Mechanism",{"VOID":1300},"[\"5187767888613366477\"]",{"VOID":1302},"Zhang QY, Wang FX, Jia KK, Kong LD. Natural product interventions for chemotherapy and radiotherapy-induced side effects. Front Pharmacol 2018;9:1253.\nSharifi-Rad J, Ozleyen A, Boyunegmez Tumer T, Oluwaseun Adetunji C, El Omari N, Balahbib A, et al. Natural products and synthetic analogs as a source of antitumor drugs. Biomolecules 2019;9:679.\nDemain AL, Vaishnav P. Natural products for cancer chemotherapy. Microb Biotechnol 2011;4:687–699.\nLichota A, Gwozdzinski K. Anticancer activity of natural compounds from plant and marine environment. Int J Molecul Sci 2018;19:3533.\nLin CC, Lin WC, Chang CH, Namba T. Antiinflammatory and hepatoprotective effects of Ventilago leiocarpa. Phytothera Res 1995;9:11–15.\nLin LC, Chou CJ, Kuo YC. Cytotoxic principles from Ventilago leiocarpa. J Natural Product 2001;64:674–676.\nLin CC, Lin JM, Chang CH, Hattori M, Namba T. Pharmacological studies on the crude drug ‘Hwang-Jin-Guey’ from Taiwan. Phytother Res 1994;8:193–200.\nFood and Drug Administration of Guangxi Zhuang Autonomous Region. Quality standards of Yao medicine in Guangxi Zhuang Autonomous Region (Volume I). Nanning: Guangxi Science and Technology Press; 2014:98–99.\nYan Z, Lai Z, Lin J. Anticancer properties of traditional Chinese medicine. Combinat Chem High Throughput Screen 2017;20:423–429.\nHu B, Wang SS, Du Q. Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: from bench to bedside. World J Hepatol 2015;7:1209–1232.\nQi F, Li A, Inagaki Y, Gao J, Li J, Kokudo N, et al. Chinese herbal medicines as adjuvant treatment during chemo- or radio-therapy for cancer. BioSci Trends 2010;4:297–307.\nLind EF, Ohashi PS. Mir-155, a central modulator of T-cell responses. Eur J Immunol 2014;44:11–15.\nCasati C, Dalerba P, Rivoltini L, Gallino G, Deho P, Rini F, et al. The apoptosis inhibitor protein survivin induces tumor-specific CD8+ and CD4+ T cells in colorectal cancer patients. Cancer Res 2003;63:4507–4515.\nCodispoti B, Makeeva I, Sied J, Benincasa C, Scacco S, Tatullo M. Should we reconsider the apoptosis as a strategic player in tissue regeneration? Int J Biol Sci 2019;15:2029–2036.\nHarikumar KB, Kuttan G, Kuttan R. Phyllanthus amarus inhibits cell growth and induces apoptosis in Dalton’s lymphoma ascites cells through activation of caspase-3 and downregulation of Bcl-2. Integr Cancer Ther 2009;8:190–194.\nJin CY, Moon DO, Choi YH, Lee JD, Kim GY. Bcl-2 and caspase-3 are major regulators in Agaricus blazei-induced human leukemic U937 cell apoptosis through dephoshorylation of Akt. Biol Pharm Bull 2007;30:1432–1437.\nKroemer G, Martin SJ. Caspase-independent cell death. Nature Med 2005;11:725–730.\nWei W, Hao EW, Zhang M, Pan XL, Qin JF, Xie JL, et al. Chemical constituents from Jasminum pentaneurum Hand.-Mazz and their cytotoxicity against human cancer cell lines. 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To study the effect of tetrandrine on morphine induced hyperactivity and reinforcement in mice.Methods: After single administration of morphine and the motion activity was measured by ambulometer, conditioned place-preference paradigm was used to study the reinforcing effect of morphine, climbing behavior was used to evaluate the relation with Dopaminergic system and immediate early expression of c-fos gene in brain was shown by immunohistochemical method.Results: Single administration of morphine could induce hyperactivity, repeated treatment would produce a conditioned place-preference response, tetrandrine 30 or 60 mg\u002Fkg hypodermic injection could inhibit the morphine induced hyperactivity, 60 mg\u002Fkg could inhibit the conditioned place-preference response but no influence on climbing behavior in mice was found. Tetrandrine could inhibit the c-fos gene expression in nucleus accumbens, ventral tegmental and prefrontal cortex in place-preference model formed by morphine.Conclusion: Tetrandrine could inhibit the hyperactivity and conditioned place-preference response induced by morphine, it might relate to reduce the c-fos gene expression in special area of brain in mice.",{"EN":1439},"Effect of tetrandrine on morphine induced hyperactivity and reinforcement in 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determine whether Schisandrin B (Sch B) attenuates early brain injury (EBI) in rats with subarachnoid hemorrhage (SAH). Sprague-Dawley rats were divided into sham (sham operation), SAH, SAH+vehicle, and SAH+Sch B groups using a random number table. Rats underwent SAH by endovascular perforation and received Sch B (100 mg\u002Fkg) or normal saline after 2 and 12 h of SAH. SAH grading, neurological scores, brain water content, Evan’s blue extravasation, and terminal transferase-mediated dUTP nick end-labeling (TUNEL) staining were carried out 24 h after SAH. Immunofluorescent staining was performed to detect the expressions of ionized calcium binding adapter molecule 1 (Iba-1) and myeloperoxidase (MPO) in the rat brain, while the expressions of B-cell lymphoma 2 (Bcl-2), Bax, Caspase-3, nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3), apoptosis-associated specklike protein containing the caspase-1 activator domain (ASC), Caspase-1, interleukin (IL)-1β, and IL-18 in the rat brains were detected by Western blot. Compared with the SAH group, Sch B significantly improved the neurological function, reduced brain water content, Evan’s blue content, and apoptotic cells number in the brain of rats (P\u003C0.05 or P\u003C0.01). Moreover, Sch B decreased SAH-induced expressions of Iba-1 and MPO (P\u003C0.01). SAH caused the elevated expressions of Bax, Caspase-3, NLRP3, ASC, Caspase-1, IL-1β, and IL-18 in the rat brain (P\u003C0.01), all of which were inhibited by Sch B (P\u003C0.01). In addition, Sch B increased the Bcl-2 expression (P\u003C0.01). Sch B attenuated SAH-induced EBI, which might be associated with the inhibition of neuroinflammation, neuronal apoptosis, and the NLRP3 inflammatory signaling pathway.",{"EN":1563},"Schisandrin B Inhibits NLRP3 Inflammasome Pathway and Attenuates Early Brain Injury in Rats of Subarachnoid Hemorrhage",{"VOID":1565},"[\"6728924743003993458\"]",{"VOID":1567},"Caner B, Hou J, Altay O, Fujii M, Zhang JH. 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Ann N Y Acad Sci 2014;1319:82–95.\nBergsbaken T, Fink SL, Cookson BT. Pyroptosis: host cell death and inflammation. Nat Rev Microbiol 2009;7:99–109.\nLin Q, Qin X, Shi M, Qin Z, Meng Y, Qin Z, et al. Schisandrin B inhibits LPS-induced inflammatory response in human umbilical vein endothelial cells by activating Nrf2. Int Immunopharmacol 2017;49:142–147.\nMou Z, Feng Z, Xu Z, Zhuang F, Zheng X, Li X, et al. Schisandrin B alleviates diabetic nephropathy through suppressing excessive inflammation and oxidative stress. Biochem Biophys Res Commun 2019;508:243–249.\nQin JH, Lin JR, Ding WF, Wu WH. Schisandrin B improves the renal function of IgA nephropathy rats through inhibition of the NF-kappaB signalling pathway. Inflammation 2019;42:884–894.\nGuo M, An F, Yu H, Wei X, Hong M, Lu Y. Comparative effects of schisandrin A, B, and C on Propionibacterium acnes-induced, NLRP3 inflammasome activation-mediated IL-1beta secretion and pyroptosis. 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