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other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. 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Nephrol Dial Transplant. 2005, 20: 1984-1988. 10.1093\u002Fndt\u002Fgfh877.",{"doi":1370},"10.1093\u002Fndt\u002Fgfh877",{"id":26,"text":1372,"url":26,"identifiers":1373},"Reinhold A, Zhang J, Gessner R, Felderhoff-Mueser U, Obladen M, Dame C: High thrombopoietin concentrations in the cerebrospinal fluid of neonates with sepsis and intraventricular hemorrhage may contribute to brain damage. J Interferon Cytokine Res. 2007, 27: 137-145. 10.1089\u002Fjir.2006.0096.",{"doi":1374},"10.1089\u002Fjir.2006.0096",{"id":26,"text":1376,"url":26,"identifiers":1377},"Suzuki H, Muramatsu M, Tanaka K, Fujiwara H, Kojima T, Taki W: Cerebrospinal fluid ferritin in chronic hydrocephalus after aneurysmal subarachnoid hemorrhage. J Neurol. 2006, 253: 1170-1176. 10.1007\u002Fs00415-006-0184-1.",{"doi":1378},"10.1007\u002Fs00415-006-0184-1",{"id":26,"text":1380,"url":26,"identifiers":1381},"Mashayekhi F, Salehi Z: Expression of nerve growth factor in cerebrospinal fluid of congenital hydrocephalic and normal children. Eur J Neurol. 2005, 12: 632-637. 10.1111\u002Fj.1468-1331.2005.01044.x.",{"doi":1382},"10.1111\u002Fj.1468-1331.2005.01044.x",{"id":26,"text":1384,"url":26,"identifiers":1385},"Chow LC, Soliman A, Zandian M, Danielpour M, Krueger RC: Accumulation of transforming growth factor-beta2 and nitrated chondroitin sulfate proteoglycans in cerebrospinal fluid correlates with poor neurologic outcome in preterm hydrocephalus. Biol Neonate. 2005, 88: 1-11. 10.1159\u002F000083945.",{"doi":1386},"10.1159\u002F000083945",{"id":26,"text":1388,"url":26,"identifiers":1389},"Flood C, Akinwunmi J, Lagord C, Daniel M, Berry M, Jackowski A, Logan A: TGF β1 in the CSF of patients with subarachnoid hemorrhage: titers derived from exogenous and endogenous sources. J Cereb Blood Flow Metab. 2001, 21: 157-162. 10.1097\u002F00004647-200102000-00007.",{"doi":1390},"10.1097\u002F00004647-200102000-00007",{"id":26,"text":1392,"url":26,"identifiers":1393},"Whitelaw A, Christie S, Pople I: TGF β1: a possible signal molecule for posthemorrhagic hydrocephalus?. Pediatr Res. 1999, 46: 576-580. 10.1203\u002F00006450-199911000-00014.",{"doi":1394},"10.1203\u002F00006450-199911000-00014",{"id":26,"text":1396,"url":26,"identifiers":1397},"Beems T, Simons KS, van Geel WJA, de Reus HPM, Vos PE, Verbeek MM: Serum and CSF-concentrations of brain specific proteins in hydrocephalus. Acta Neurochir (Wien). 2003, 145: 37-43. 10.1007\u002Fs00701-002-1019-1.",{"doi":1398},"10.1007\u002Fs00701-002-1019-1",{"id":26,"text":1400,"url":26,"identifiers":1401},"Sendrowski K, Sobaniec W, Sobaniec-Lotowska ME, Lewczuk PS: S-100 protein as marker of the blood-brain barrier disruption in children with internal hydrocephalus and epilepsy--a preliminary study. Roczniki Akademii Medycznej W Bialymstoku. 2004, 49 (Suppl 1): 236-238.",{},{"id":26,"text":1403,"url":26,"identifiers":1404},"Heep A, Stoffel-Wagner B, Bartmann P, Benseler S, Schaller C, Groneck P, Obladen M, Felderhoff-Mueser U: Vascular endothelial growth factor and transforming growth factor-beta1 are highly expressed in the cerebrospinal fluid of premature infants with posthemorrhagic hydrocephalus. Pediatric Res. 2004, 56: 768-774. 10.1203\u002F01.PDR.0000141524.32142.53.",{"doi":1405},"10.1203\u002F01.PDR.0000141524.32142.53",{"id":26,"text":1407,"url":26,"identifiers":1408},"Tarnaris A, Watkins LD, Kitchen ND: Biomarkers in chronic adult hydrocephalus. Cerebrospinal Fluid Res. 2006, 3: 11-10.1186\u002F1743-8454-3-11.",{"doi":1409},"10.1186\u002F1743-8454-3-11",{"id":26,"text":1411,"url":26,"identifiers":1412},"Nooijen PT, Schoonderwaldt HC, Wevers RA, Hommes OR, Lamers KJ: Neuronspecific enolase, S-100 protein, myelin basic protein and lactate in CSF in dementia. Dement Geriatr Cogn Disord. 1997, 8: 169-173. 10.1159\u002F000106627.",{"doi":1413},"10.1159\u002F000106627",{"id":26,"text":1415,"url":26,"identifiers":1416},"Nussinovitch M, Volovitz B, Finkelstein Y, Amir J, Harel D: Lactic dehydrogenase isoenzymes in cerebrospinal fluid associated with hydrocephalus. Acta Paediatr. 2001, 90: 972-974. 10.1080\u002F080352501316978020.",{"doi":1417},"10.1111\u002Fj.1651-2227.2001.tb01350.x",{"id":26,"text":1419,"url":26,"identifiers":1420},"Cerda M, Manterola A, Ponce S, Basauri L: Electrolyte levels in the CSF of children with non-tumoral hydrocephalus. Childs Nerv Syst. 1985, 6: 306-311. 10.1007\u002FBF00270813.",{"doi":1421},"10.1007\u002FBF00270813",{"id":26,"text":1423,"url":26,"identifiers":1424},"Del Bigio MR: Hydrocephalus-induced changes in the composition of cerebrospinal fluid. Neurosurgery. 1989, 25: 416-423. 10.1097\u002F00006123-198909000-00016.",{"doi":1425},"10.1227\u002F00006123-198909000-00016",{"id":26,"text":1427,"url":26,"identifiers":1428},"Whitelaw A, Pople I, Cherian S, Evans D, Thoresen M: Phase I trial of prevention of hydrocephalus after intraventricular hemorrhage in newborn infants by drainage, irrigation and fibrinolytic therapy. Pediatrics. 2003, 111: 759-765. 10.1542\u002Fpeds.111.4.759.",{"doi":1429},"10.1542\u002Fpeds.111.4.759",{"id":26,"text":1431,"url":26,"identifiers":1432},"Perrata P, Regazzi P, Carlino CF, Gaglini P, Cinalli G: The role of Ommaya reservoir and endoscopic third ventriculostomy in the management of post hemorrhagic hydrocephalus in prematurity. Childs Nerv Syst. 2007, 23: 765-771. 10.1007\u002Fs00381-006-0291-4.",{"doi":1433},"10.1007\u002Fs00381-006-0291-4",{"id":26,"text":1435,"url":26,"identifiers":1436},"Brinker T, Seifert V, Dietz H: Subacute hydrocephalus after experimental subarachnoid hemorrhage: its prevention by intrathecal fibrinolysis with recombinant tissue plasminogen activator. Neurosurgery. 1992, 31: 306-311. 10.1097\u002F00006123-199208000-00016.",{"doi":1437},"10.1227\u002F00006123-199208000-00016",{"id":26,"text":1439,"url":26,"identifiers":1440},"Wald A, Hochwald GM, Malhan C: The effects of ventricular fluid osmolality on bulk flow of nascent fluid into the cerebral ventricles of cats. Exp Brain Res. 1976, 25: 157-167. 10.1007\u002FBF00234900.",{"doi":1441},"10.1007\u002FBF00234900",{"id":26,"text":1443,"url":26,"identifiers":1444},"DiMattio J, Hochwald GM, Malhan C, Wald A: Effects of changes in serum osmolality on bulk flow of fluid into cerebral ventricles and on brain water content. Pflugers Arch. 1975, 359: 253-264. 10.1007\u002FBF00587383.",{"doi":1445},"10.1007\u002FBF00587383",{"id":26,"text":1447,"url":26,"identifiers":1448},"Alonso MI, Gato A, Moro JA, Barbosa E: Disruption of proteoglycans in neural tube fluid by β-D xyloside alters brain enlargement in chick embryos. Anat Rec. 1998, 252: 499-508. 10.1002\u002F(SICI)1097-0185(199812)252:4\u003C499::AID-AR1>3.0.CO;2-1.",{"doi":1449},"10.1002\u002F(SICI)1097-0185(199812)252:4\u003C499::AID-AR1>3.0.CO;2-1",{"id":26,"text":1451,"url":26,"identifiers":1452},"Lowery LA, Sive H: Initial formation of zebrafish ventricles occurs independently of circulation and requires nagie oko and snakehead\u002Fatp1a1a.1 gene products. Development. 2005, 132: 2057-2067. 10.1242\u002Fdev.01791.",{"doi":1453},"10.1242\u002Fdev.01791",{"id":1455,"createTime":1456,"updateTime":1457,"relativeEntities":1458,"slug":1459,"properties":1460,"entityType":711,"verifyStatus":25,"verifyTime":1479,"verifyNote":712,"syncStatus":28,"languages":1480,"translateLanguages":1481,"viewCount":36,"primaryUrl":1482,"fullTextUrl":26,"authors":1483,"publicationType":881,"publisherRelationship":1561,"citationCount":252,"citationInfo":1575,"publishDate":1577,"publishYear":1578,"citationAnalyzeStatus":900,"lastCitationAnalyze":1579,"indexDatabases":26,"openAccess":26,"references":1580,"isForceReanalyzing":1136},"c531e5d5-6ad5-4487-932f-0503c84c5b0d","2024-04-11T13:14:31.193+00:00","2025-01-28T15:29:58.025+00:00",[],"The-subcommissural-organ-of-the-rat-secretes-Reissner-s-fiber-glycoproteins-and-CSF-soluble-proteins-reaching-the-internal-and-external-CSF-compartments",{"mag":1461,"keywords":1463,"pmc":1465,"openalex":1467,"abstract":1469,"title":1472,"pm":1475,"doi":1477},{"VOID":1462},"2122618633",{"VI":1464},"",{"VOID":1466},"2265671",{"VOID":1468},"W2122618633",{"VI":1470,"EN":1471},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Đề cương\u003C\u002Fjats:title>\n            \u003Cjats:p>Tổ chức dưới tia (SCO) là một tuyến não được bảo tồn cao có mặt trên toàn bộ phylum động vật có xương sống; nó tiết ra glycoprotein vào dịch não tủy (CSF), nơi chúng tập hợp lại để tạo thành sợi Reissner (RF). SCO-spondin là protein thành phần chính của RF. Có bằng chứng cho thấy SCO cũng tiết ra protein vẫn hòa tan trong CSF. Mục tiêu của cuộc điều tra hiện tại là: (i) xác định và phân tích một phần các hợp chất tiết ra từ SCO có mặt trong chính tuyến SCO và trong RF của chuột Sprague-Dawley và chuột hyh không bị não úng thủy, cùng với CSF của chuột; (ii) thực hiện phân tích so sánh các protein có mặt trong ba ngăn này; (iii) xác định các protein được SCO tiết ra vào CSF trong các giai đoạn phát triển khác nhau.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Phương pháp\u003C\u002Fjats:title>\n            \u003Cjats:p>Các protein được SCO tiết ra vào CSF được nghiên cứu (i) bằng cách tiêm kháng thể đặc hiệu vào dịch não thất \u003Cjats:italic>in vivo\u003C\u002Fjats:italic>; (ii) thông qua kỹ thuật blots miễn dịch của các mẫu SCO, RF và CSF, sử dụng kháng thể đặc hiệu chống lại các protein tiết ra từ SCO (AFRU và anti-P15). Ngoài ra, bản chất glycosylated của các hợp chất SCO được phân tích bằng cách gắn kết concanavalin A và wheat germ agglutinin. Để phân tích glycoprotein RF, RF được chiết xuất từ ống trung tâm của chuột con; để nghiên cứu các protein hòa tan trong CSF do SCO tiết ra, các mẫu CSF được thu thập từ cisterna magna của chuột ở các giai đoạn phát triển khác nhau (từ E18 đến PN30).\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết quả\u003C\u002Fjats:title>\n            \u003Cjats:p>Năm glycoprotein đã được xác định trong SCO của chuột cống với trọng lượng phân tử biểu kiến là 630, 450, 390, 320 và 200 kDa. Ngoại trừ hợp chất 200-kDa, tất cả các hợp chất khác có mặt trong SCO của chuột cống cũng được tìm thấy trong SCO của chuột. Các hợp chất 630 và 390 kDa của SCO chuột cống có độ gắn kết với concanavalin A nhưng không với wheat germ agglutinin, gợi ý rằng chúng tương ứng với các dạng tiền thân. Bốn hợp chất có hoạt tính miễn dịch AFRU có mặt trong SCO (630, 450, 390, 320 kDa) vắng mặt trong RF và CSF. Chúng có thể là các dạng tiền thân và\u002Fhoặc đã được xử lý một phần. Hai hợp chất khác (200, 63 kDa) có mặt trong SCO, RF và CSF và có thể là các dạng đã được xử lý. Sự hiện diện của các protein này trong cả RF và CSF cho thấy một trạng thái cân bằng RF\u002FCSF ổn định cho các hợp chất này. Tám băng có hoạt tính miễn dịch AFRU đã được phát hiện nhất quán trong các mẫu CSF từ chuột cống ở các thời điểm E18, E20 và PN1. Chỉ bốn trong số các hợp chất này được phát hiện trong CSF trong cisterna của chuột cống PN30. Hợp chất 200 kDa dường như là một hợp chất then chốt trong chuột cống vì nó được phát hiện nhất quán trong tất cả các mẫu của SCO, RF và CSF phôi và chuột con.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết luận\u003C\u002Fjats:title>\n            \u003Cjats:p>Chúng tôi kết luận rằng (i) trong giai đoạn cuối của cuộc sống phôi, SCO của chuột cống tiết ra các hợp chất vẫn hòa tan trong CSF và đạt được không gian dưới màng nhện; (ii) trong cuộc sống sau sinh, số lượng và nồng độ các protein hòa tan trong CSF do SCO tiết ra giảm xuống. Cấu trúc phân tử và ý nghĩa chức năng của các protein này vẫn cần được làm rõ. Khả năng chúng tham gia vào sự phát triển của não cũng đã được thảo luận.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>The subcommissural organ (SCO) is a highly conserved brain gland present throughout the vertebrate phylum; it secretes glycoproteins into the cerebrospinal fluid (CSF), where they aggregate to form Reissner's fiber (RF). SCO-spondin is the major constituent protein of RF. Evidence exists that the SCO also secretes proteins that remain soluble in the CSF. The aims of the present investigation were: (i) to identify and partially characterize the SCO-secretory compounds present in the SCO gland itself and in the RF of the Sprague-Dawley rat and non-hydrocephalic hyh mouse, and in the CSF of rat; (ii) to make a comparative analysis of the proteins present in these three compartments; (iii) to identify the proteins secreted by the SCO into the CSF at different developmental periods.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Methods\u003C\u002Fjats:title>\n            \u003Cjats:p>The proteins of the SCO secreted into the CSF were studied (i) by injecting specific antibodies into ventricular CSF \u003Cjats:italic>in vivo\u003C\u002Fjats:italic>; (ii) by immunoblots of SCO, RF and CSF samples, using specific antibodies against the SCO secretory proteins (AFRU and anti-P15). In addition, the glycosylated nature of SCO-compounds was analysed by concanavalin A and wheat germ agglutinin binding. To analyse RF-glycoproteins, RF was extracted from the central canal of juvenile rats and mice; to investigate the CSF-soluble proteins secreted by the SCO, CSF samples were collected from the cisterna magna of rats at different stages of development (from E18 to PN30).\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>Five glycoproteins were identified in the rat SCO with apparent molecular weights of 630, 450, 390, 320 and 200 kDa. With the exception of the 200-kDa compound, all other compounds present in the rat SCO were also present in the mouse SCO. The 630 and 390 kDa compounds of the rat SCO have affinity for concanavalin A but not for wheat germ agglutinin, suggesting that they correspond to precursor forms. Four of the AFRU-immunoreactive compounds present in the SCO (630, 450, 390, 320 kDa) were absent from the RF and CSF. These may be precursor and\u002For partially processed forms. Two other compounds (200, 63 kDa) were present in SCO, RF and CSF and may be processed forms. The presence of these proteins in both, RF and CSF suggests a steady-state RF\u002FCSF equilibrium for these compounds. Eight AFRU-immunoreactive bands were consistently found in CSF samples from rats at E18, E20 and PN1. Only four of these compounds were detected in the cisternal CSF of PN30 rats. The 200 kDa compound appears to be a key compound in rats since it was consistently found in all samples of SCO, RF and embryonic and juvenile CSF.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusion\u003C\u002Fjats:title>\n            \u003Cjats:p>It is concluded that (i) during the late embryonic life, the rat SCO secretes compounds that remain soluble in the CSF and reach the subarachnoid space; (ii) during postnatal life, there is a reduction in the number and concentration of CSF-soluble proteins secreted by the SCO. The molecular structure and functional significance of these proteins remain to be elucidated. The possibility they are involved in brain development has been discussed.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"VI":1473,"EN":1474},"Tổ chức dưới tia của chuột cống tiết ra glycoprotein Reissner và protein hòa tan trong dịch não tủy đến các ngăn dịch não tủy bên trong và bên ngoài","The subcommissural organ of the rat secretes Reissner's fiber glycoproteins and CSF-soluble proteins reaching the internal and external CSF compartments",{"VOID":1476},"18218138",{"VOID":1478},"10.1186\u002F1743-8454-5-3","2025-01-01T00:50:54.953+00:00",[102],[101],"https:\u002F\u002Ffluidsbarrierscns.biomedcentral.com\u002Farticles\u002F10.1186\u002F1743-8454-5-3",[1484,1501,1515,1529,1545],{"id":1485,"sortIndex":114,"researcher":26,"roles":1486,"affiliations":1487,"properties":1496},"6cbecf8b-d45f-4b0e-80cc-015270b06909",[],[1488],{"id":26,"sortIndex":36,"affiliation":1489,"properties":26},{"id":1490,"createTime":1491,"updateTime":1491,"relativeEntities":1492,"slug":26,"properties":1493,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"78d734f4-358c-4271-9732-5f45b2e70b7a","2024-01-01T12:36:51.997+00:00",[],{"title":1494},{"VI":1495},"Instituto de Anatomía, Histología y Patología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile",{"openalex":1497,"title":1499},{"VOID":1498},"A5031453452",{"EN":1500},"Carlos R. 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The Subcommissural Organ An Ependymal Brain Gland. Edited by: Oksche A, Rodriguez EM, Fernandez-Llebrez P. 1993, Berlin, Heidelberg, New York: Springer, 41-49.",{"doi":1584},"10.1007\u002F978-3-642-78013-4_6",{"id":26,"text":1586,"url":26,"identifiers":1587},"Rodriguez EM, Oksche A, Montecinos H: Human subcommissural organ, with particular emphasis on its secretory activity during the fetal life. Microsc Res Tech. 2001, 52: 573-590. 10.1002\u002F1097-0029(20010301)52:5\u003C573::AID-JEMT1042>3.0.CO;2-6.",{"doi":1588},"10.1002\u002F1097-0029(20010301)52:5\u003C573::AID-JEMT1042>3.0.CO;2-6",{"id":26,"text":1590,"url":26,"identifiers":1591},"Reissner E: Beiträge zur Kenntnis vom Bau des Rüchenmarks von Petromyzon fluviatilis L. Arch anat physiol. 1860, 77: 545-588.",{},{"id":26,"text":1593,"url":26,"identifiers":1594},"Rodriguez EM, Oksche A, Hein S, Yulis CR: Cell biology of the subcommissural organ. Int Rev Cytol. 1992, 135: 39-121.",{"doi":1595},"10.1016\u002FS0074-7696(08)62038-0",{"id":26,"text":1597,"url":26,"identifiers":1598},"Rodriguez EM, Rodriguez S, Hein S: The subcommissural organ. Microsc Res Tech. 1998, 41: 98-123. 10.1002\u002F(SICI)1097-0029(19980415)41:2\u003C98::AID-JEMT2>3.0.CO;2-M.",{"doi":1599},"10.1002\u002F(SICI)1097-0029(19980415)41:2\u003C98::AID-JEMT2>3.0.CO;2-M",{"id":26,"text":1601,"url":26,"identifiers":1602},"Peruzzo B, Rodriguez S, Delannoy L, Hein S, Rodriguez EM, Oksche A: Ultrastructural immunocytochemical study of the massa caudalis of the subcommissural organ-Reissner's fiber complex in lamprey larvae (Geotria australis): evidence for a terminal vascular route of secretory material. Cell Tissue Res. 1987, 247: 367-376. 10.1007\u002FBF00218318.",{"doi":1603},"10.1007\u002FBF00218318",{"id":26,"text":1605,"url":26,"identifiers":1606},"Rodriguez S, Rodriguez PA, Bance P, Rodriguez EM, Oksche A: Reissner's fiber, massa caudalis and ampulla caudalis in the spinal cord of lamprey larvae (Geotria australis). Light-microscopic immunocytochemical and lectin-histochemical studies. Cell Tissue Res. 1987, 247: 359-366. 10.1007\u002FBF00218317.",{"doi":1607},"10.1007\u002FBF00218317",{"id":26,"text":1609,"url":26,"identifiers":1610},"Caprile T, Hein S, Rodriguez S, Montecinos H, Rodriguez E: Reissner fiber binds and transports away monoamines present in the cerebrospinal fluid. Brain Res Mol Brain Res. 2003, 110: 177-192. 10.1016\u002FS0169-328X(02)00565-X.",{"doi":1611},"10.1016\u002FS0169-328X(02)00565-X",{"id":26,"text":1613,"url":26,"identifiers":1614},"Rodriguez S, Vio K, Wagner C, Barria M, Navarrete EH, Ramirez VD, Perez-Figares JM, Rodriguez EM: Changes in the cerebrospinal-fluid monoamines in rats with an immunoneutralization of the subcommissural organ-Reissner's fiber complex by maternal delivery of antibodies. Exp Brain Res. 1999, 128: 278-290. 10.1007\u002Fs002210050848.",{"doi":1615},"10.1007\u002Fs002210050848",{"id":26,"text":1617,"url":26,"identifiers":1618},"Hein S, Nualart F, Rodriguez EM, Oksche A: Partial characterization of the secretory products of the subcommisural organ. The Subcommissural Organ An Ependymal Brain Gland. Edited by: Oksche A, Rodriguez EM, Fernandez-Llebrez P. 1993, Berlin, Heidelberg, New York: Springer, 78-88.",{},{"id":26,"text":1620,"url":26,"identifiers":1621},"Nualart F, Hein S: Biosynthesis and molecular biology of the secretory proteins of the subcommissural organ. Microsc Res Tech. 2001, 52: 468-483. 10.1002\u002F1097-0029(20010301)52:5\u003C468::AID-JEMT1033>3.0.CO;2-U.",{"doi":1622},"10.1002\u002F1097-0029(20010301)52:5\u003C468::AID-JEMT1033>3.0.CO;2-U",{"id":26,"text":1624,"url":26,"identifiers":1625},"Nualart F, Hein S, Rodriguez EM, Oksche A: Identification and partial characterization of the secretory glycoproteins of the bovine subcommissural organ-Reissner's fiber complex. Evidence for the existence of two precursor forms. Brain Res Mol Brain Res. 1991, 11: 227-238. 10.1016\u002F0169-328X(91)90031-R.",{"doi":1626},"10.1016\u002F0169-328X(91)90031-R",{"id":26,"text":1628,"url":26,"identifiers":1629},"del Brio MA, Riera P, Munoz RI, Montecinos H, Rodriguez EM: The metencephalic floor plate of chick embryos expresses two secretory glycoproteins homologous with the two glycoproteins secreted by the subcommissural organ. Histochem Cell Biol. 2000, 113: 415-426.",{"doi":1630},"10.1007\u002Fs004180000136",{"id":26,"text":1632,"url":26,"identifiers":1633},"Lopez-Avalos MD, Perez J, Perez-Figares JM, Peruzzo B, Grondona JM, Rodriguez EM: Secretory glycoproteins of the subcommissural organ of the dogfish (Scyliorhinus canicula): evidence for the existence of precursor and processed forms. Cell Tissue Res. 1996, 283: 75-84. 10.1007\u002Fs004410050514.",{"doi":1634},"10.1007\u002Fs004410050514",{"id":26,"text":1636,"url":26,"identifiers":1637},"Schoebitz K, Garrido O, Heinrichs M, Speer L, Rodriguez EM: Ontogenetical development of the chick and duck subcommissural organ. An immunocytochemical study. Histochemistry. 1986, 84: 31-40. 10.1007\u002FBF00493417.",{"doi":1638},"10.1007\u002FBF00493417",{"id":26,"text":1640,"url":26,"identifiers":1641},"Rodriguez EM, Jara P, Richter H, Montecinos H, Flandes B, Wiegand R, Oksche A: Evidence for the release of CSF-soluble secretory material from the subcommissural organ, with particular reference to the situation in the human. The Subcommissural Organ An Ependymal Brain Gland. Edited by: Oksche A, Rodriguez EM, Fernandez-Llebrez P. 1993, Berlin, Heidelberg, New York: Springer, 121-131.",{"doi":1642},"10.1007\u002F978-3-642-78013-4_14",{"id":26,"text":1644,"url":26,"identifiers":1645},"Hoyo-Becerra C, Lopez-Avalos MD, Perez J, Miranda E, Rojas-Rios P, Fernandez-Llebrez P, Grondona JM: Continuous delivery of a monoclonal antibody against Reissner's fiber into CSF reveals CSF-soluble material immunorelated to the subcommissural organ in early chick embryos. Cell Tissue Res. 2006, 326: 771-786. 10.1007\u002Fs00441-006-0231-3.",{"doi":1646},"10.1007\u002Fs00441-006-0231-3",{"id":26,"text":1648,"url":26,"identifiers":1649},"Estivill-Torrus G, Cifuentes M, Grondona JM, Miranda E, Bermudez-Silva FJ, Fernandez-Llebrez P, Perez J: Quantification of the secretory glycoproteins of the subcommissural organ by a sensitive sandwich ELISA with a polyclonal antibody and a set of monoclonal antibodies against the bovine Reissner's fiber. Cell Tissue Res. 1998, 294: 407-413. 10.1007\u002Fs004410051191.",{"doi":1650},"10.1007\u002Fs004410051191",{"id":26,"text":1652,"url":26,"identifiers":1653},"Fernandez-Llebrez P, Miranda E, Estivill-Torrus G, Cifuentes M, Grondona JM, Lopez-Avalos MD, Perez-Martin M, Perez J: Analysis and quantification of the secretory products of the subcommissural organ by use of monoclonal antibodies. Microsc Res Tech. 2001, 52: 510-519. 10.1002\u002F1097-0029(20010301)52:5\u003C510::AID-JEMT1036>3.0.CO;2-A.",{"doi":1654},"10.1002\u002F1097-0029(20010301)52:5\u003C510::AID-JEMT1036>3.0.CO;2-A",{"id":26,"text":1656,"url":26,"identifiers":1657},"Gobron S, Creveaux I, Meiniel R, Didier R, Herbet A, Bamdad M, El Bitar F, Dastugue B, Meiniel A: Subcommissural organ\u002FReissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth. Glia. 2000, 32: 177-191. 10.1002\u002F1098-1136(200011)32:2\u003C177::AID-GLIA70>3.0.CO;2-V.",{"doi":1658},"10.1002\u002F1098-1136(200011)32:2\u003C177::AID-GLIA70>3.0.CO;2-V",{"id":26,"text":1660,"url":26,"identifiers":1661},"Meiniel A: SCO-spondin, a glycoprotein of the subcommissural organ\u002FReissner's fiber complex: evidence of a potent activity on neuronal development in primary cell cultures. Microsc Res Tech. 2001, 52: 484-495. 10.1002\u002F1097-0029(20010301)52:5\u003C484::AID-JEMT1034>3.0.CO;2-0.",{"doi":1662},"10.1002\u002F1097-0029(20010301)52:5\u003C484::AID-JEMT1034>3.0.CO;2-0",{"id":26,"text":1664,"url":26,"identifiers":1665},"Adams JC, Tucker RP: The thrombospondin type 1 repeat (TSR) superfamily: diverse proteins with related roles in neuronal development. Dev Dyn. 2000, 218: 280-299. 10.1002\u002F(SICI)1097-0177(200006)218:2\u003C280::AID-DVDY4>3.0.CO;2-0.",{"doi":1666},"10.1002\u002F(SICI)1097-0177(200006)218:2\u003C280::AID-DVDY4>3.0.CO;2-0",{"id":26,"text":1668,"url":26,"identifiers":1669},"Sternberger LA, Hardy PH, Cuculis JJ, Meyer HG: The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem. 1970, 18: 315-333.",{"doi":1670},"10.1177\u002F18.5.315",{"id":26,"text":1672,"url":26,"identifiers":1673},"Rodriguez EM, Oksche A, Hein S, Rodriguez S, Yulis R: Comparative immunocytochemical study of the subcommissural organ. Cell Tissue Res. 1984, 237: 427-441.",{},{"id":26,"text":1675,"url":26,"identifiers":1676},"Nualart F, Hein S, Yulis CR, Zarraga AM, Araya A, Rodriguez EM: Partial sequencing of Reissner's fiber glycoprotein I (RF-Gly I). Cell Tissue Res. 1998, 292: 239-250. 10.1007\u002Fs004410051055.",{"doi":1677},"10.1007\u002Fs004410051055",{"id":26,"text":1679,"url":26,"identifiers":1680},"Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976, 72: 248-254. 10.1016\u002F0003-2697(76)90527-3.",{"doi":1681},"10.1016\u002F0003-2697(76)90527-3",{"id":26,"text":1683,"url":26,"identifiers":1684},"Towbin H, Staehelin T, Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA. 1979, 76: 4350-4354. 10.1073\u002Fpnas.76.9.4350.",{"doi":1685},"10.1073\u002Fpnas.76.9.4350",{"id":26,"text":1687,"url":26,"identifiers":1688},"Herrera H, Rodriguez EM: Secretory glycoproteins of the rat subcommissural organ are N-linked complex-type glycoproteins. Demonstration by combined use of lectins and specific glycosidases, and by the administration of Tunicamycin. Histochemistry. 1990, 93: 607-615. 10.1007\u002FBF00272203.",{"doi":1689},"10.1007\u002FBF00272203",{"id":26,"text":1691,"url":26,"identifiers":1692},"Peruzzo B, Rodriguez EM: Light and electron microscopical demonstration of concanavalin A and wheat-germ agglutinin binding sites by use of antibodies against the lectin or its label (peroxidase). Histochemistry. 1989, 92: 505-513. 10.1007\u002FBF00524762.",{"doi":1693},"10.1007\u002FBF00524762",{"id":26,"text":1695,"url":26,"identifiers":1696},"Goncalves-Mendes N, Simon-Chazottes D, Creveaux I, Meiniel A, Guenet JL, Meiniel R: Mouse SCO-spondin, a gene of the thrombospondin type 1 repeat (TSR) superfamily expressed in the brain. Gene. 2003, 312: 263-270. 10.1016\u002FS0378-1119(03)00622-X.",{"doi":1697},"10.1016\u002FS0378-1119(03)00622-X",{"id":26,"text":1699,"url":26,"identifiers":1700},"Rodriguez EM, del Brio Leon MA, Riera P, Menendez J, Schoebitz K: The floor plate of the hindbrain is a highly specialized gland. Immunocytochemical and ultrastructural characteristics. Brain Res Dev Brain Res. 1996, 97: 153-168. 10.1016\u002FS0165-3806(96)00113-7.",{"doi":1701},"10.1016\u002FS0165-3806(96)00113-7",{"id":26,"text":1703,"url":26,"identifiers":1704},"Guinazu MF, Richter HG, Rodriguez EM: Bovine floor plate explants secrete SCO-spondin. Cell Tissue Res. 2002, 308: 177-191. 10.1007\u002Fs00441-002-0511-5.",{"doi":1705},"10.1007\u002Fs00441-002-0511-5",{"id":26,"text":1707,"url":26,"identifiers":1708},"Meiniel A, Meiniel R, Didier R, Creveaux I, Gobron S, Monnerie H, Dastugue B: The subcommissural organ and Reissner's fiber complex. An enigma in the central nervous system?. Prog Histochem Cytochem. 1996, 30: 1-66.",{"doi":1709},"10.1016\u002FS0079-6336(96)80015-5",{"id":26,"text":1711,"url":26,"identifiers":1712},"Rodriguez S, Hein S, Yulis R, Delannoy L, Siegmund I, Rodriguez E: Reissner's fiber and the wall of the central canal in the lumbo-sacral region of the bovine spinal cord. Comparative immunocytochemical and ultrastructural study. Cell Tissue Res. 1985, 240: 649-662. 10.1007\u002FBF00216353.",{"doi":1713},"10.1007\u002FBF00216353",{"id":26,"text":1715,"url":26,"identifiers":1716},"Rodriguez S, Rodriguez EM, Jara P, Peruzzo B, Oksche A: Single injection into the cerebrospinal fluid of antibodies against the secretory material of the subcommissural organ reversibly blocks formation of Reissner's fiber: immunocytochemical investigations in the rat. Exp Brain Res. 1990, 81: 113-124. 10.1007\u002FBF00230107.",{"doi":1717},"10.1007\u002FBF00230107",{"id":26,"text":1719,"url":26,"identifiers":1720},"Olsson R: Reissner's fiber mechanisms: some common denominators. The Subcommissural Organ An Ependymal Brain Gland. Edited by: Oksche A, Rodriguez EM, Fernandez-Llebrez P. 1993, Berlin, Heidelberg, New York: Springer, 33-39.",{"doi":1721},"10.1007\u002F978-3-642-78013-4_5",{"id":26,"text":1723,"url":26,"identifiers":1724},"Yulis CR, Mota MD, Andrades JA, Rodriguez S, Peruzzo B, Mancera JM, Ramirez P, Garrido M, Perez-Figarez JM, Fernandez-Llebrez P, Rodriguez EM: Floor plate and the subcommissural organ are the source of secretory compounds of related nature: comparative immunocytochemical study. J Comp Neurol. 1998, 392: 19-34. 10.1002\u002F(SICI)1096-9861(19980302)392:1\u003C19::AID-CNE2>3.0.CO;2-S.",{"doi":1725},"10.1002\u002F(SICI)1096-9861(19980302)392:1\u003C19::AID-CNE2>3.0.CO;2-S",{"id":26,"text":1727,"url":26,"identifiers":1728},"Rodriguez EM, Garrido O, Oksche A: Lectin histochemistry of the human fetal subcommissural organ. Cell Tissue Res. 1990, 262: 105-113. 10.1007\u002FBF00327751.",{"doi":1729},"10.1007\u002FBF00327751",{"id":26,"text":1731,"url":26,"identifiers":1732},"Richter HG, Munoz RI, Millan CS, Guinazu MF, Yulis CR, Rodriguez EM: The floor plate cells from bovines express the mRNA encoding for SCO-spondin and its translation products. Brain Res Mol Brain Res. 2001, 93: 137-147. 10.1016\u002FS0169-328X(01)00181-4.",{"doi":1733},"10.1016\u002FS0169-328X(01)00181-4",{"id":26,"text":1735,"url":26,"identifiers":1736},"Owen-Lynch PJ, Draper CE, Mashayekhi F, Bannister CM, Miyan JA: Defective cell cycle control underlies abnormal cortical development in the hydrocephalic Texas rat. Brain. 2003, 126: 623-631. 10.1093\u002Fbrain\u002Fawg058.",{"doi":1737},"10.1093\u002Fbrain\u002Fawg058",{"id":26,"text":1739,"url":26,"identifiers":1740},"Miyan JA, Nabiyouni M, Zendah M: Development of the brain: a vital role for cerebrospinal fluid. Can J Physiol Pharmacol. 2003, 81: 317-328. 10.1139\u002Fy03-027.",{"doi":1741},"10.1139\u002Fy03-027",{"id":26,"text":1743,"url":26,"identifiers":1744},"Rodriguez EM: The cerebrospinal fluid as a pathway in neuroendocrine integration. J Endocrinol. 1976, 71: 407-443.",{"doi":1745},"10.1677\u002Fjoe.0.0710407",{"id":26,"text":1747,"url":26,"identifiers":1748},"Brightman MW: The distribution within the brain of ferritin injected into cerebrospinal fluid compartments. I. Ependymal distribution. J Cell Biol. 1965, 26: 99-123. 10.1083\u002Fjcb.26.1.99.",{"doi":1749},"10.1083\u002Fjcb.26.1.99",{"id":26,"text":1751,"url":26,"identifiers":1752},"Brightman MW, Reese TS: Junctions between intimately apposed cell membranes in the vertebrate brain. J Cell Biol. 1969, 40: 648-677. 10.1083\u002Fjcb.40.3.648.",{"doi":1753},"10.1083\u002Fjcb.40.3.648",{"id":26,"text":1755,"url":26,"identifiers":1756},"Cifuentes M, Fernandez LP, Perez J, Perez-Figares JM, Rodriguez EM: Distribution of intraventricularly injected horseradish peroxidase in cerebrospinal fluid compartments of the rat spinal cord. Cell Tissue Res. 1992, 270: 485-494. 10.1007\u002FBF00645050.",{"doi":1757},"10.1007\u002FBF00645050",{"id":26,"text":1759,"url":26,"identifiers":1760},"Brightman MW: The distribution within the brain of ferritin injected into cerebrospinal fluid compartments. II. Parenchymal distribution. Am J Anat. 1965, 117: 193-219. 10.1002\u002Faja.1001170204.",{"doi":1761},"10.1002\u002Faja.1001170204",{"id":26,"text":1763,"url":26,"identifiers":1764},"Rennels ML, Gregory TF, Blaumanis OR, Fujimoto K, Grady PA: Evidence for a 'paravascular' fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space. Brain Res. 1985, 326: 47-63. 10.1016\u002F0006-8993(85)91383-6.",{"doi":1765},"10.1016\u002F0006-8993(85)91383-6",{"id":26,"text":1767,"url":26,"identifiers":1768},"Pena P, Rodriguez EM, Dellmann HD, Schoebitz K: Effects of colchicine on the hypothalamo-neurohypophysial system of chronically salt-loaded rats. Neuroendocrinology. 1988, 47: 217-224.",{"doi":1769},"10.1159\u002F000124915",{"id":26,"text":1771,"url":26,"identifiers":1772},"Miyan JA, Mashayekhi F, Bannister CM: Developmental abnormalities in early-onset hydrocephalus: clues to signalling. Symp Soc Exp Biol. 2001, 91-106.",{},{"id":26,"text":1774,"url":26,"identifiers":1775},"Gato A, Moro JA, Alonso MI, Bueno D, De La Mano A, Martin C: Embryonic cerebrospinal fluid regulates neuroepithelial survival, proliferation, and neurogenesis in chick embryos. Anat Rec A Discov Mol Cell Evol Biol. 2005, 284: 475-484.",{"doi":1776},"10.1002\u002Far.a.20185",{"id":26,"text":1778,"url":26,"identifiers":1779},"Miyan JA, Zendah M, Mashayekhi F, Owen-Lynch PJ: Cerebrospinal fluid supports viability and proliferation of cortical cells in vitro, mirroring in vivo development. Cerebrospinal Fluid Res. 2006, 3: 2-10.1186\u002F1743-8454-3-2.",{"doi":1780},"10.1186\u002F1743-8454-3-2",{"id":26,"text":1782,"url":26,"identifiers":1783},"Gonzalez C, Vio K, Muñoz RI, Rodriguez EM: The CSF of normal H-Tx rats promotes neuronal differentiation from neurospheres but CSF of hydrocephalic H-Tx rats does not. Cerebrospinal Fluid Res. 2006, 3: s10-10.1186\u002F1743-8454-3-S1-S10.",{"doi":1784},"10.1186\u002F1743-8454-3-S1-S10",{"id":26,"text":1786,"url":26,"identifiers":1787},"Doublier S, Duyckaerts C, Seurin D, Binoux M: Impaired brain development and hydrocephalus in a line of transgenic mice with liver-specific expression of human insulin-like growth factor binding protein-1. Growth Horm IGF Res. 2000, 10: 267-274. 10.1054\u002Fghir.2000.0168.",{"doi":1788},"10.1054\u002Fghir.2000.0168",{"id":26,"text":1790,"url":26,"identifiers":1791},"Kasaian MT, Neet KE: Nerve growth factor in human amniotic and cerebrospinal fluid. Biofactors. 1989, 2: 99-104.",{},{"id":26,"text":1793,"url":26,"identifiers":1794},"Johnson MD, Gold LI, Moses HL: Evidence for transforming growth factor-beta expression in human leptomeningeal cells and transforming growth factor-beta-like activity in human cerebrospinal fluid. Lab Invest. 1992, 67: 360-368.",{},{"id":26,"text":1796,"url":26,"identifiers":1797},"Mogi M, Harada M, Narabayashi H, Inagaki H, Minami M, Nagatsu T: Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease. Neurosci Lett. 1996, 211: 13-16. 10.1016\u002F0304-3940(96)12706-3.",{"doi":1798},"10.1016\u002F0304-3940(96)12706-3",{"id":26,"text":1800,"url":26,"identifiers":1801},"Heinze E, Boker M, Blum W, Behnisch W, Schulz A, Urban J, Mauch E: GH, IGF-I, IGFBP-3 and IGFBP-2 in cerebrospinal fluid of infants, during puberty and in adults. Exp Clin Endocrinol Diabetes. 1998, 106: 197-202.",{"doi":1802},"10.1055\u002Fs-0029-1211976",{"id":26,"text":1804,"url":26,"identifiers":1805},"Arnold PM, Ma JY, Citron BA, Festoff BW: Insulin-like growth factor binding proteins in cerebrospinal fluid during human development and aging. Biochem Biophys Res Commun. 1999, 264: 652-656. 10.1006\u002Fbbrc.1999.1555.",{"doi":1806},"10.1006\u002Fbbrc.1999.1555",{"id":26,"text":1808,"url":26,"identifiers":1809},"Johanson CE, Szmydynger-Chodobska J, Chodobski A, Baird A, McMillan P, Stopa EG: Altered formation and bulk absorption of cerebrospinal fluid in FGF-2-induced hydrocephalus. Am J Physiol. 1999, 277: R263-271.",{},{"id":26,"text":1811,"url":26,"identifiers":1812},"Riikonen R, Somer M, Turpeinen U: Low insulin-like growth factor (IGF-1) in the cerebrospinal fluid of children with progressive encephalopathy, hypsarrhythmia, and optic atrophy (PEHO) syndrome and cerebellar degeneration. Epilepsia. 1999, 40: 1642-1648. 10.1111\u002Fj.1528-1157.1999.tb02051.x.",{"doi":1813},"10.1111\u002Fj.1528-1157.1999.tb02051.x",{"id":26,"text":1815,"url":26,"identifiers":1816},"Moinuddin SM, Tada T: Study of cerebrospinal fluid flow dynamics in TGF-beta 1 induced chronic hydrocephalic mice. Neurol Res. 2000, 22: 215-222.",{"doi":1817},"10.1080\u002F01616412.2000.11741064",{"id":26,"text":1819,"url":26,"identifiers":1820},"Montecinos HA, Richter H, Caprile T, Rodriguez EM: Synthesis of transthyretin by the ependymal cells of the subcommissural organ. Cell Tissue Res. 2005, 320: 487-499. 10.1007\u002Fs00441-004-0997-0.",{"doi":1821},"10.1007\u002Fs00441-004-0997-0",{"id":26,"text":1823,"url":26,"identifiers":1824},"Vio K, Rodriguez S, Navarrete EH, Perez-Figares JM, Jimenez AJ, Rodriguez EM: Hydrocephalus induced by immunological blockage of the subcommissural organ-Reissner's fiber (RF) complex by maternal transfer of anti-RF antibodies. Exp Brain Res. 2000, 135: 41-52. 10.1007\u002Fs002210000474.",{"doi":1825},"10.1007\u002Fs002210000474",{"id":26,"text":1827,"url":26,"identifiers":1828},"Monnerie H, Dastugue B, Meiniel A: Effect of synthetic peptides derived from SCO-spondin conserved domains on chick cortical and spinal-cord neurons in cell cultures. Cell Tissue Res. 1998, 293: 407-418. 10.1007\u002Fs004410051132.",{"doi":1829},"10.1007\u002Fs004410051132",{"id":26,"text":1831,"url":26,"identifiers":1832},"Rice DS, Curran T: Role of the reelin signaling pathway in central nervous system development. Annu Rev Neurosci. 2001, 24: 1005-1039. 10.1146\u002Fannurev.neuro.24.1.1005.",{"doi":1833},"10.1146\u002Fannurev.neuro.24.1.1005",{"id":26,"text":1835,"url":26,"identifiers":1836},"Gonzalez C: Participación del órgano subcomisural y el líquido cefalorraquídeo en la neurogénesis postnatal. PhD Thesis. 2007, Universidad Austral de Chile, Institute of Anatomy, Histology and Pathology, Faculty of Medicine",{},{"id":1838,"createTime":1839,"updateTime":1840,"relativeEntities":1841,"slug":1842,"properties":1843,"entityType":711,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":1861,"translateLanguages":1862,"viewCount":36,"primaryUrl":1863,"fullTextUrl":26,"authors":1864,"publicationType":881,"publisherRelationship":2063,"citationCount":287,"citationInfo":2082,"publishDate":2084,"publishYear":2085,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":2086,"isForceReanalyzing":1136},"48894359-7f51-4190-b8e7-b6d673b788a8","2024-04-20T06:16:51.097+00:00","2025-01-28T15:30:55.221+00:00",[],"Diffusion-tensor-imaging-correlates-with-cytopathology-in-a-rat-model-of-neonatal-hydrocephalus",{"mag":1844,"keywords":1846,"pmc":1847,"openalex":1849,"abstract":1851,"title":1854,"pm":1857,"doi":1859},{"VOID":1845},"2123993059",{"VI":1464},{"VOID":1848},"2989304",{"VOID":1850},"W2123993059",{"VI":1852,"EN":1853},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Điều kiện nền tảng\u003C\u002Fjats:title>\n            \u003Cjats:p>Hình ảnh tensor khuếch tán (DTI) là một kỹ thuật MRI không xâm lấn được sử dụng để định lượng các bất thường của hệ thần kinh trung ương (CNS) trong nhiều tình trạng bệnh lý khác nhau. Nghiên cứu này được thiết kế để định lượng đặc tính khuếch tán bất đối xứng trong não của chuột con mắc bệnh hydrocephalus (HCP) và điều tra mối liên quan giữa các phép đo DTI và bệnh lý tế bào.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Phương pháp\u003C\u002Fjats:title>\n            \u003Cjats:p>Dữ liệu DTI được thu thập từ ngày thứ 7 sau sinh (P7) đến P12 ở 12 con chuột mắc HCP được gây ra vào P2 và 15 con chuột điều khiển đồng tuổi. Các động vật được euthanasia vào P11 hoặc P22\u002FP23 và não được xử lý bằng kỹ thuật nhuộm miễn dịch hóa học cho protein axit fibrillary glial (GFAP), phân tử gắn ion canxi (Iba-1), và nhuộm Luxol Fast Blue (LFB) để đánh giá mức độ tế bào sao, phản ứng của vi tâm bào và mức độ myelination tương ứng.","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>Diffusion tensor imaging (DTI) is a non-invasive MRI technique that has been used to quantify CNS abnormalities in various pathologic conditions. This study was designed to quantify the anisotropic diffusion properties in the brain of neonatal rats with hydrocephalus (HCP) and to investigate association between DTI measurements and cytopathology.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Methods\u003C\u002Fjats:title>\n            \u003Cjats:p>DTI data were acquired between postnatal day 7 (P7) and P12 in 12 rats with HCP induced at P2 and in 15 age-matched controls. Animals were euthanized at P11 or P22\u002FP23 and brains were processed with immunohistochemistry for glial fibrillary acidic protein (GFAP), ionized calcium-binding adaptor molecule (Iba-1), and luxol fast blue (LFB) to assess astrocytosis, microglial reactivity and degree of myelination, respectively.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>Hydrocephalic rats were consistently found to have an abnormally low (at corrected \u003Cjats:italic>p\u003C\u002Fjats:italic>-level of <0.05) fractional anisotropy (FA) value and an abnormally high mean diffusivity (MD) value in the cerebral cortex (CX), the corpus callosum (CC), and the internal capsule (IC). Immunohistochemical analysis demonstrated trends of increasing astrocyte and microglial reactivity in HCP rats at P11 that reached statistical significance at P22\u002FP23. A trend toward reduced myelination in the HCP rats was also found at P22\u002FP23. Correlation analysis at P11 for the CC demonstrated statistically significant correlations (or trends) between the DTI measurement (the decreased FA and increased MD values) and the GFAP or Iba-1 rankings. The immunohistochemical rankings in the IC at P22\u002FP23 were also significantly correlated or demonstrated a trend with both FA and MD values.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusions\u003C\u002Fjats:title>\n            \u003Cjats:p>This study demonstrates the feasibility of employing DTI on the brain in experimental hydrocephalus in neonatal rats and reveals impairments in multiple regions of interest in both grey and white matter. A strong correlation was found between the immunohistochemical results and the changes in anisotropic diffusion properties.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"VI":1855,"EN":1856},"Hình ảnh tensor khuếch tán tương quan với bệnh tế bào trong mô hình chuột nhiễm hydrocephalus ở trẻ sơ sinh","Diffusion tensor imaging correlates with cytopathology in a rat model of neonatal hydrocephalus",{"VOID":1858},"21054844",{"VOID":1860},"10.1186\u002F1743-8454-7-19",[102],[101],"https:\u002F\u002Ffluidsbarrierscns.biomedcentral.com\u002Farticles\u002F10.1186\u002F1743-8454-7-19",[1865,1885,1902,1923,1942,1959,1980,1997,2018,2035,2050],{"id":1866,"sortIndex":50,"researcher":26,"roles":1867,"affiliations":1868,"properties":1880},"02581cd5-bc0a-4308-9984-278df46db7a5",[],[1869],{"id":1870,"sortIndex":36,"affiliation":1871,"properties":26},"fba4dc81-a8cc-43ea-a11b-f933d8fcae8c",{"id":1872,"createTime":1873,"updateTime":1874,"relativeEntities":1875,"slug":1876,"properties":1877,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"03a197c3-6f03-4a21-9068-447da4569cb9","2024-04-20T06:16:51.236+00:00","2025-06-11T16:57:29.211+00:00",[],"Division-of-Pediatric-Neurosurgery-University-of-Cincinnati-Cincinnati-Children-s-Hospital-Medical-Center-MLC-2016-3333-Burnet-Avenue-Cincinnati-OH-45229-USA",{"title":1878},{"EN":1879},"Division of Pediatric Neurosurgery, University of Cincinnati, Cincinnati Children's Hospital Medical Center MLC 2016, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA",{"openalex":1881,"title":1883},{"VOID":1882},"A5074452912",{"EN":1884},"Dean A. 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Exp Neurol. 2010, 226: 110-119. 10.1016\u002Fj.expneurol.2010.08.010.",{"doi":2204},"10.1016\u002Fj.expneurol.2010.08.010",{"id":26,"text":2206,"url":26,"identifiers":2207},"Yuan W, Holland SK, Schmithorst VJ, Walz NC, Cecil KM, Jones BV, Karunanayaka P, Michaud L, Wade SL: Diffusion tensor MR imaging reveals persistent white matter alteration after traumatic brain injury experienced during early childhood. AJNR Am J Neuroradiol. 2007, 28: 1919-1925. 10.3174\u002Fajnr.A0698.",{"doi":2208},"10.3174\u002Fajnr.A0698",{"id":26,"text":2210,"url":26,"identifiers":2211},"Yuan W, Holland SK, Jones BV, Crone K, Mangano FT: Characterization of abnormal diffusion properties of supratentorial brain tumors: a preliminary diffusion tensor imaging study. 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Brain Res Dev Brain Res. 1998, 108: 287-293. 10.1016\u002FS0165-3806(98)00063-7.",{"doi":2254},"10.1016\u002FS0165-3806(98)00063-7",{"id":2256,"createTime":2257,"updateTime":2258,"relativeEntities":2259,"slug":2260,"properties":2261,"entityType":711,"verifyStatus":25,"verifyTime":2258,"verifyNote":712,"syncStatus":28,"languages":2279,"translateLanguages":2280,"viewCount":36,"primaryUrl":2281,"fullTextUrl":26,"authors":2282,"publicationType":881,"publisherRelationship":2358,"citationCount":240,"citationInfo":2372,"publishDate":2374,"publishYear":2375,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":2376,"isForceReanalyzing":1136},"ef3645c2-9e32-4106-afa4-c462f1f3b8c4","2024-04-15T16:13:57.246+00:00","2025-02-17T13:26:38.560+00:00",[],"In-vitro-hydrodynamic-properties-of-the-Miethke-proGAV-hydrocephalus-shunt",{"mag":2262,"keywords":2264,"pmc":2265,"openalex":2267,"abstract":2269,"title":2272,"pm":2275,"doi":2277},{"VOID":2263},"2101166274",{"VI":1464},{"VOID":2266},"1552084",{"VOID":2268},"W2101166274",{"VI":2270,"EN":2271},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Nền tảng\u003C\u002Fjats:title>\n            \u003Cjats:p>Các ống dẫn điều chỉnh được rất phổ biến trong quản lý tình trạng não thất nở (hydrocephalus) và được cho là giúp giảm thiểu số lượng các lần phẫu thuật sửa đổi. Nhược điểm của hầu hết các cấu trúc này là chúng có thể bị điều chỉnh lại một cách tình cờ trong các trường từ trường khá yếu (khoảng 30–40 mTesla).\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Vật liệu và phương pháp\u003C\u002Fjats:title>\n            \u003Cjats:p>Ống dẫn Miethke ProGav bao gồm một đơn vị van lò xo bóng có thể điều chỉnh và một thiết bị bù quá thoát nước nhờ trọng lực tích hợp (được gọi là trợ lý dẫn). Một 'phanh' cơ học được thiết kế để ngăn chặn sự thay đổi hiệu suất của van trong trường từ trường mạnh. Chúng tôi đã đánh giá hiệu suất và các thuộc tính thủy động học của một mẫu ba van tại Phòng thí nghiệm Đánh giá Ống dẫn Vương quốc Anh.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết quả\u003C\u002Fjats:title>\n            \u003Cjats:p>Tất cả các ống dẫn cho thấy độ bền cơ học tốt trong suốt thời gian thử nghiệm ba tháng, và tính ổn định tốt của hiệu suất thủy động học trong suốt một tháng.\u003C\u002Fjats:p>\n            \u003Cjats:p>Các đường cong hiệu suất áp suất - dòng chảy, áp suất vận hành, mở và đóng nằm trong giới hạn được quy định bởi nhà sản xuất, và thay đổi theo các mức hiệu suất đã lập trình. Áp suất vận hành tăng khi trợ lý dẫn ở vị trí thẳng đứng, như đã quy định. Van có độ kháng thủy động học thấp (0.53 mm mmHg ml\u003Cjats:sup>-1\u003C\u002Fjats:sup> min\u003Cjats:sup>-1\u003C\u002Fjats:sup>). Việc lập trình bên ngoài đã chứng minh là dễ dàng và đáng tin cậy. Các trường từ trường mạnh từ máy quét MR 3 Tesla không thể thay đổi việc lập trình của van.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết luận\u003C\u002Fjats:title>\n            \u003Cjats:p>Ống dẫn ProGAV là một van có thể điều chỉnh, có độ kháng thấp, có khả năng hạn chế tình trạng quá thoát nước liên quan đến tư thế. Khác với các van điều chỉnh khác, ProGAV không thể bị điều chỉnh lại một cách tình cờ bởi trường từ bên ngoài như máy quét MR 3T.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>Adjustable shunts are very popular in the management of hydrocephalus and are believed to help in minimizing the number of surgical revisions. The drawback with almost all constructions is that they may be accidentally readjusted in relatively weak magnetic fields (around 30–40 mTesla)\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Materials and methods\u003C\u002Fjats:title>\n            \u003Cjats:p>The ProGav Miethke shunt is composed of an adjustable ballon-spring valve unit and an integrated over-drainage compensating gravitational device (known as the shunt assistant). A mechanical 'brake' is intended to prevent changes to the valve's performance level in a strong magnetic field. We evaluated the performance and hydrodynamic properties of a sample of three valves in the UK Shunt Evaluation Laboratory.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>All the shunts showed good mechanical durability over the three-month period of testing, and good stability of hydrodynamic performance over a one-month period\u003C\u002Fjats:p>\n            \u003Cjats:p>The pressure-flow performance curves, operating, opening and closing pressures fell within the limits specified by the manufacturer, and changed according to the programmed performance levels. The operating pressure increased when the shunt assistant was in the vertical position, as specified. The valve has a low hydrodynamic resistance (0.53 mm mmHg ml\u003Cjats:sup>-1\u003C\u002Fjats:sup> min\u003Cjats:sup>-1\u003C\u002Fjats:sup>). External programming proved to be easy and reliable. Strong magnetic fields from a 3 Tesla MR scanner were not able to change the programming of the valve.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusion\u003C\u002Fjats:title>\n            \u003Cjats:p>The ProGAV shunt is an adjustable, low resistance valve that is able to limit posture-related over-drainage. Unlike other adjustable valves, the ProGAV cannot be accidentally re-adjusted by external magnetic field such as a 3T MR scanner.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"VI":2273,"EN":2274},"Các thuộc tính thủy động học của ống dẫn nước não thất Miethke proGAV trong điều kiện in vitro","In vitro hydrodynamic properties of the Miethke proGAV hydrocephalus shunt",{"VOID":2276},"16808836",{"VOID":2278},"10.1186\u002F1743-8454-3-9",[102],[101],"https:\u002F\u002Ffluidsbarrierscns.biomedcentral.com\u002Farticles\u002F10.1186\u002F1743-8454-3-9",[2283,2300,2314,2330,2344],{"id":2284,"sortIndex":114,"researcher":26,"roles":2285,"affiliations":2286,"properties":2295},"615b1efd-2367-4e60-9072-4eafd69856fb",[],[2287],{"id":26,"sortIndex":36,"affiliation":2288,"properties":26},{"id":2289,"createTime":2290,"updateTime":2290,"relativeEntities":2291,"slug":26,"properties":2292,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"306be939-1bea-40c0-b453-ac196e550582","2023-12-11T08:48:54.123+00:00",[],{"title":2293},{"VI":2294},"Academic Neurosurgical Unit, Addenbrooke's Hospital, Cambridge, UK",{"openalex":2296,"title":2298},{"VOID":2297},"A5027157412",{"EN":2299},"Marek Czosnyka",{"id":2301,"sortIndex":36,"researcher":26,"roles":2302,"affiliations":2303,"properties":2309},"f41ebb29-34fc-409f-a837-671050a01b72",[],[2304],{"id":26,"sortIndex":36,"affiliation":2305,"properties":26},{"id":2289,"createTime":2290,"updateTime":2290,"relativeEntities":2306,"slug":26,"properties":2307,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":2308},{"VI":2294},{"openalex":2310,"title":2312},{"VOID":2311},"A5042044859",{"EN":2313},"David Allin",{"id":2315,"sortIndex":111,"researcher":26,"roles":2316,"affiliations":2317,"properties":2323},"df403a56-5378-4eec-9f96-2a4084b92f7d",[],[2318],{"id":26,"sortIndex":36,"affiliation":2319,"properties":26},{"id":2289,"createTime":2290,"updateTime":2290,"relativeEntities":2320,"slug":26,"properties":2321,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":2322},{"VI":2294},{"openalex":2324,"orcid":2326,"title":2328},{"VOID":2325},"A5046998828",{"VOID":2327},"https:\u002F\u002Forcid.org\u002F0000-0002-5762-6667",{"EN":2329},"John D. Pickard",{"id":2331,"sortIndex":115,"researcher":26,"roles":2332,"affiliations":2333,"properties":2339},"17f781a6-769a-4b2c-ac48-7fdedd85c2c8",[],[2334],{"id":26,"sortIndex":36,"affiliation":2335,"properties":26},{"id":2289,"createTime":2290,"updateTime":2290,"relativeEntities":2336,"slug":26,"properties":2337,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":2338},{"VI":2294},{"openalex":2340,"title":2342},{"VOID":2341},"A5027976352",{"EN":2343},"Zofia Czosnyka",{"id":2345,"sortIndex":59,"researcher":26,"roles":2346,"affiliations":2347,"properties":2353},"0d94f4e8-fa88-4980-ba9f-4193ca76b4a3",[],[2348],{"id":26,"sortIndex":36,"affiliation":2349,"properties":26},{"id":2289,"createTime":2290,"updateTime":2290,"relativeEntities":2350,"slug":26,"properties":2351,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":2352},{"VI":2294},{"openalex":2354,"title":2356},{"VOID":2355},"A5052155407",{"EN":2357},"Hugh K. Richards",{"url":26,"publisher":2359,"properties":26},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":2360,"slug":663,"properties":2361,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":2364,"manageAffiliations":2365,"indexDatabases":2366,"url":672,"thumbnailPath":26,"statistic":2367,"gsStatistic":26,"type":175,"analyzePriority":26},[],{"issn":2362,"title":2363},{"VOID":666},{"EN":668},[],[],[],{"impactFactor":36,"impactFactorByYear":2368,"i10Index":50,"i10IndexLast5Year":36,"totalPublication":675,"totalPublicationByYear":2369,"totalCitation":678,"totalCitationByYear":2370,"totalCitationPerPublication":680,"totalCitationPerPublicationByYear":2371,"hindexLast5Year":50,"hindex":50},{"2012":341},{"2004":283,"2005":204,"2006":677,"2007":517,"2008":116,"2009":251,"2010":204},{"2005":111,"2006":282,"2007":59,"2008":569,"2009":627,"2010":286},{"2005":171,"2006":682,"2007":110,"2008":683,"2009":684,"2010":685},{"total":240,"publishYear":26,"statisticByYear":2373},{"2012":114,"2013":59,"2014":59,"2016":115,"2018":59,"2020":59,"2022":115,"2023":114},"2006-12-01",2006,[2377,2381,2385,2389,2393,2397,2401,2405,2409,2413,2417],{"id":26,"text":2378,"url":26,"identifiers":2379},"Albeck MJ, Borgesen SE, Gjerris F, Schmidt JF, Sorensen PS: Intracranial pressure and cerebrospinal fluid outflow conductance in healthy subjects. J Neurosurg. 1991, 74 (4): 597-600.",{"doi":2380},"10.3171\u002Fjns.1991.74.4.0597",{"id":26,"text":2382,"url":26,"identifiers":2383},"Inoue T, Kuzu Y, Ogasawara K, Ogawa A: Effect of 3-tesla magnetic resonance imaging on various pressure programmable shunt valves. J Neurosurg. 2005, 163-165. Suppl 2",{"doi":2384},"10.3171\u002Fped.2005.103.2.0163",{"id":26,"text":2386,"url":26,"identifiers":2387},"Nomura S, Fujisawa H, Suzuki M: Effect of cell phone magnetic fields on adjustable cerebrospinal fluid shunt valves. Surg Neurol. 2005, 63: 467-8. 10.1016\u002Fj.surneu.2004.06.022.",{"doi":2388},"10.1016\u002Fj.surneu.2004.06.022",{"id":26,"text":2390,"url":26,"identifiers":2391},"Anderson RC, Walker ML, Viner JM, Kestle JR: Adjustment and malfunction of a programmable valve after exposure to toy magnets. Case report. J Neurosurg. 2004, 222-5. Suppl 2",{"doi":2392},"10.3171\u002Fped.2004.101.2.0222",{"id":26,"text":2394,"url":26,"identifiers":2395},"Schneider T, Knauff U, Nitsch J, Firsching R: Electromagnetic field hazards involving adjustable shunt valves in hydrocephalus. J Neurosurg. 2002, 96: 331-4.",{"doi":2396},"10.3171\u002Fjns.2002.96.2.0331",{"id":26,"text":2398,"url":26,"identifiers":2399},"Sprung C, Miethke C, Schlosser HG, Brock M: The enigma of underdrainage in shunting with hydrostatic valves and possible solutions. Acta Neurochir Suppl. 2005, 95: 229-35.",{"doi":2400},"10.1007\u002F3-211-32318-X_47",{"id":26,"text":2402,"url":26,"identifiers":2403},"Lindner D, Preul C, Trantakis C, Moeller H, Meixensberger J: Effect of 3T MRI on the function of shunt valves – evaluation of Paedi GAV, Dual Switch and proGAV. Eur J Radiol. 2005, 56: 56-9. 10.1016\u002Fj.ejrad.2005.03.029.",{"doi":2404},"10.1016\u002Fj.ejrad.2005.03.029",{"id":26,"text":2406,"url":26,"identifiers":2407},"Czosnyka Z, Czosnyka M, Richards HK, Pickard JD: Laboratory Testing of Hydrocephalus Shunts – Conclusion of the U.K. Shunt Evaluation Programme. Acta Neurochir. 2002, 144: 525-538. 10.1007\u002Fs00701-002-0922-9.",{"doi":2408},"10.1007\u002Fs00701-002-0922-9",{"id":26,"text":2410,"url":26,"identifiers":2411},"Czosnyka Z, Cieslicki K, Czosnyka M, Pickard JD: Hydrocephalus shunts and waves of intracranial pressure. Med Biol Eng Comput. 2005, 43: 71-77. 10.1007\u002FBF02345125.",{"doi":2412},"10.1007\u002FBF02345125",{"id":26,"text":2414,"url":26,"identifiers":2415},"Bech-Azeddine R, Gjerris F, Waldemar G, Czosnyka M, Juhler M: Intraventricular or lumbar infusion test in adult communicating hydrocephalus? Practical consequences and clinical outcome of shunt operation. Acta Neurochir (Wien). 2005, 147: 1027-36. 10.1007\u002Fs00701-005-0589-0.",{"doi":2416},"10.1007\u002Fs00701-005-0589-0",{"id":26,"text":2418,"url":26,"identifiers":2419},"O'Kane MC, Richards H, Winfield P, Pickard JD: The United Kingdom Shunt Registry. Eur J Pediatr Surg. 1997, 1 (Suppl 7): 56.",{},{"id":2421,"createTime":2422,"updateTime":2423,"relativeEntities":2424,"slug":2425,"properties":2426,"entityType":711,"verifyStatus":25,"verifyTime":2444,"verifyNote":712,"syncStatus":28,"languages":2445,"translateLanguages":2446,"viewCount":36,"primaryUrl":2447,"fullTextUrl":26,"authors":2448,"publicationType":881,"publisherRelationship":2571,"citationCount":173,"citationInfo":2585,"publishDate":1577,"publishYear":1578,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":2587,"isForceReanalyzing":1136},"3cdaa15a-b1be-42df-925b-7491d6b3d274","2024-04-16T02:35:11.673+00:00","2025-01-28T15:32:55.460+00:00",[],"Prostaglandin-E2metabolism-in-rat-brain-Role-of-the-blood-brain-interfaces",{"mag":2427,"keywords":2429,"pmc":2430,"openalex":2432,"abstract":2434,"title":2437,"pm":2440,"doi":2442},{"VOID":2428},"2028266179",{"VI":1464},{"VOID":2431},"2292143",{"VOID":2433},"W2028266179",{"VI":2435,"EN":2436},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Giới thiệu\u003C\u002Fjats:title>\n            \u003Cjats:p>Prostaglandin E\u003Cjats:sub>2\u003C\u002Fjats:sub> (PGE\u003Cjats:sub>2\u003C\u002Fjats:sub>) tham gia vào việc điều chỉnh hoạt động synap và tính dẻo dai, cũng như trong sự trưởng thành của não bộ. Nó cũng là một chất trung gian quan trọng trong phản ứng trung tâm đối với các thách thức viêm nhiễm. Mục tiêu của nghiên cứu này là đánh giá khả năng của các mô tạo thành các giao diện máu-não trong việc đóng vai trò như các vị trí kết thúc tín hiệu cho PGE\u003Cjats:sub>2\u003C\u002Fjats:sub> thông qua quá trình bất hoạt chuyển hóa.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Phương pháp\u003C\u002Fjats:title>\n            \u003Cjats:p>Hoạt động đặc hiệu của 15-hydroxyprostaglandin dehydrogenase đã được đo trong các chế phẩm đồng nhất từ các mạch máu nhỏ, màng mạch và vỏ não tách ra từ não chuột non và trưởng thành, và so sánh với hoạt động đo được ở các cơ quan ngoại vi đã được xác định là các vị trí kết thúc tín hiệu cho prostaglandins. Các chất chuyển hóa của PGE\u003Cjats:sub>2\u003C\u002Fjats:sub> được sản xuất \u003Cjats:italic>ex vivo\u003C\u002Fjats:italic> bởi màng mạch đã được xác định và định lượng bằng phương pháp HPLC kết hợp với phát hiện bằng hóa phóng xạ.\n\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết quả\u003C\u002Fjats:title>\n            \u003Cjats:p>Dữ liệu xác nhận sự vắng mặt của hoạt động chuyển hóa trong nhu mô não, và cho thấy rằng không có hoạt động có thể phát hiện được liên quan đến các mạch máu nhỏ trong não tạo thành hàng rào máu-não. Ngược lại, hoạt động của 15-hydroxyprostaglandin dehydrogenase đã được đo ở cả màng mạch của não thất thứ tư và não thất bên từ chuột 2 ngày tuổi, mặc dù ở mức thấp hơn so với phổi hoặc thận. Hoạt động này hầu như không thể phát hiện được ở mô màng mạch trưởng thành. Các hồ sơ chuyển hóa cho thấy rằng màng mạch tách biệt có khả năng chuyển hóa PGE\u003Cjats:sub>2\u003C\u002Fjats:sub>, chủ yếu thành 13,14-dihydro-15-keto-PGE\u003Cjats:sub>2\u003C\u002Fjats:sub>. Trong các buổi nuôi cấy ngắn hạn, chất chuyển hóa này phân bố trong các mô thay vì trong môi trường bên ngoài, cho thấy việc giải phóng của nó vào stroma màng mạch.\n\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết luận\u003C\u002Fjats:title>\n            \u003Cjats:p>Mô màng mạch của chuột có khả năng đáng kể trong việc chuyển hóa PGE\u003Cjats:sub>2\u003C\u002Fjats:sub> trong giai đoạn đầu của cuộc sống sau sinh. Hoạt động chuyển hóa này có thể tham gia vào việc kết thúc tín hiệu của PGE\u003Cjats:sub>2\u003C\u002Fjats:sub> được giải phóng trung tâm trong não, hoặc hoạt động như một hàng rào enzym để duy trì sự đồng nhất của PGE\u003Cjats:sub>2\u003C\u002Fjats:sub> trong dịch não tủy trong giai đoạn quan trọng đầu sau sinh của sự phát triển não bộ.","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>Prostaglandin E\u003Cjats:sub>2\u003C\u002Fjats:sub> (PGE\u003Cjats:sub>2\u003C\u002Fjats:sub>) is involved in the regulation of synaptic activity and plasticity, and in brain maturation. It is also an important mediator of the central response to inflammatory challenges. The aim of this study was to evaluate the ability of the tissues forming the blood-brain interfaces to act as signal termination sites for PGE\u003Cjats:sub>2\u003C\u002Fjats:sub> by metabolic inactivation.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Methods\u003C\u002Fjats:title>\n            \u003Cjats:p>The specific activity of 15-hydroxyprostaglandin dehydrogenase was measured in homogenates of microvessels, choroid plexuses and cerebral cortex isolated from postnatal and adult rat brain, and compared to the activity measured in peripheral organs which are established signal termination sites for prostaglandins. PGE\u003Cjats:sub>2\u003C\u002Fjats:sub> metabolites produced \u003Cjats:italic>ex vivo\u003C\u002Fjats:italic> by choroid plexuses were identified and quantified by HPLC coupled to radiochemical detection.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>The data confirmed the absence of metabolic activity in brain parenchyma, and showed that no detectable activity was associated with brain microvessels forming the blood-brain barrier. By contrast, 15-hydroxyprostaglandin dehydrogenase activity was measured in both fourth and lateral ventricle choroid plexuses from 2-day-old rats, albeit at a lower level than in lung or kidney. The activity was barely detectable in adult choroidal tissue. Metabolic profiles indicated that isolated choroid plexus has the ability to metabolize PGE\u003Cjats:sub>2\u003C\u002Fjats:sub>, mainly into 13,14-dihydro-15-keto-PGE\u003Cjats:sub>2\u003C\u002Fjats:sub>. In short-term incubations, this metabolite distributed in the tissue rather than in the external medium, suggesting its release in the choroidal stroma.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusion\u003C\u002Fjats:title>\n            \u003Cjats:p>The rat choroidal tissue has a significant ability to metabolize PGE\u003Cjats:sub>2\u003C\u002Fjats:sub> during early postnatal life. This metabolic activity may participate in signal termination of centrally released PGE\u003Cjats:sub>2\u003C\u002Fjats:sub> in the brain, or function as an enzymatic barrier acting to maintain PGE\u003Cjats:sub>2\u003C\u002Fjats:sub> homeostasis in CSF during the critical early postnatal period of brain development.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"VI":2438,"EN":2439},"Chuyển hóa Prostaglandin E2 trong não chuột: Vai trò của các giao diện máu-não","Prostaglandin E2metabolism in rat brain: Role of the blood-brain 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Norway",{"openalex":2736,"title":2738},{"VOID":2737},"A5029070964",{"EN":2739},"Mary Kalfoss",{"id":2741,"sortIndex":115,"researcher":26,"roles":2742,"affiliations":2743,"properties":2753},"4d7efd26-4462-4034-b5d6-4553e63354a0",[],[2744],{"id":26,"sortIndex":36,"affiliation":2745,"properties":26},{"id":2746,"createTime":2747,"updateTime":2747,"relativeEntities":2748,"slug":2749,"properties":2750,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"1263e045-3fe3-4d0b-844f-2e147d9df6cf","2024-04-13T10:10:19.417+00:00",[],"Spina-Bifida-Program-Health-and-Science-University-PO-Box-574-Portland-Oregon-USA",{"title":2751},{"EN":2752},"Spina Bifida Program, Health and Science University, PO Box 574, Portland, Oregon, USA",{"openalex":2754,"title":2756},{"VOID":2755},"A5070811489",{"EN":2757},"Mark Merkens",{"url":26,"publisher":2759,"properties":26},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":2760,"slug":663,"properties":2761,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":2764,"manageAffiliations":2765,"indexDatabases":2766,"url":672,"thumbnailPath":26,"statistic":2767,"gsStatistic":26,"type":175,"analyzePriority":26},[],{"issn":2762,"title":2763},{"VOID":666},{"EN":668},[],[],[],{"impactFactor":36,"impactFactorByYear":2768,"i10Index":50,"i10IndexLast5Year":36,"totalPublication":675,"totalPublicationByYear":2769,"totalCitation":678,"totalCitationByYear":2770,"totalCitationPerPublication":680,"totalCitationPerPublicationByYear":2771,"hindexLast5Year":50,"hindex":50},{"2012":341},{"2004":283,"2005":204,"2006":677,"2007":517,"2008":116,"2009":251,"2010":204},{"2005":111,"2006":282,"2007":59,"2008":569,"2009":627,"2010":286},{"2005":171,"2006":682,"2007":110,"2008":683,"2009":684,"2010":685},{"total":103,"publishYear":26,"statisticByYear":2773},{"2012":115,"2013":114,"2014":115,"2015":114,"2016":114,"2021":115},"2024-04-13T19:36:22.214+00:00",[],{"id":2777,"createTime":2778,"updateTime":2779,"relativeEntities":2780,"slug":2781,"properties":2782,"entityType":711,"verifyStatus":25,"verifyTime":2800,"verifyNote":712,"syncStatus":28,"languages":2801,"translateLanguages":2802,"viewCount":36,"primaryUrl":2803,"fullTextUrl":26,"authors":2804,"publicationType":881,"publisherRelationship":2903,"citationCount":53,"citationInfo":2917,"publishDate":2374,"publishYear":2375,"citationAnalyzeStatus":900,"lastCitationAnalyze":2919,"indexDatabases":26,"openAccess":26,"references":2920,"isForceReanalyzing":1136},"feecfbd5-cd3d-4f6d-85fa-43fdf86b8045","2024-04-12T02:18:30.183+00:00","2025-01-28T15:33:56.967+00:00",[],"Uneven-distribution-of-nucleoside-transporters-and-intracellular-enzymatic-degradation-prevent-transport-of-intact-14C-adenosine-across-the-sheep-choroid-plexus-epithelium-as-a-monolayer-in-primary-culture",{"mag":2783,"keywords":2785,"pmc":2786,"openalex":2788,"abstract":2790,"title":2793,"pm":2796,"doi":2798},{"VOID":2784},"1563560049",{"VI":1464},{"VOID":2787},"1450313",{"VOID":2789},"W1563560049",{"VI":2791,"EN":2792},"\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Nền\u003C\u002Fjats:title>\n            \u003Cjats:p>Sự vận chuyển adenosine qua biểu mô của màng đệm (CP) có thể góp phần duy trì trạng thái cân bằng của neuromodulator này trong dịch ngoại bào của não. Mục đích của nghiên cứu này là khám phá sự vận chuyển adenosine qua các lớp tế bào biểu mô CP của cừu trong nuôi cấy nguyên phát.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Phương pháp\u003C\u002Fjats:title>\n            \u003Cjats:p>Để khám phá sự vận chuyển adenosine qua biểu mô CP, chúng tôi đã phát triển \u003Cjats:bold>một\u003C\u002Fjats:bold> phương pháp nuôi cấy nguyên phát các tế bào biểu mô màng đệm cừu (CPEC) trên các nền nhựa thấm và phân tích sự vận chuyển adenosine [\u003Cjats:sup>14\u003C\u002Fjats:sup>C] qua lớp tế bào này, chuyển hóa adenosine [\u003Cjats:sup>14\u003C\u002Fjats:sup>C] bên trong tế bào và sự hấp thu tế bào đối với adenosine [\u003Cjats:sup>14\u003C\u002Fjats:sup>C] từ bất kỳ buồng nào. Nuôi cấy tế bào nguyên phát bao gồm một phân đoạn tế bào biểu mô giàu có từ CP thất thứ tư của cừu và được nuôi trong các insert lọc được phủ laminin.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết quả và kết luận\u003C\u002Fjats:title>\n            \u003Cjats:p>CPEC phát triển thành các lớp đơn tạo thành các đảo hình đa giác điển hình, đạt được sự đồng nhất quang học vào ngày thứ ba sau khi đông đảo. Điện trở xuyên biểu mô gia tăng theo thời gian sau khi nuôi cấy lên đến 85 ± 9 Ω cm\u003Cjats:sup>2\u003C\u002Fjats:sup> vào ngày thứ 8, trong khi tính thấm đối với [\u003Cjats:sup>14\u003C\u002Fjats:sup>C] sucrose, một dấu hiệu của sự khuếch tán ngoài tế bào, đồng thời giảm. Những tế bào này thể hiện một số đặc điểm điển hình của CPEC \u003Cjats:italic>tại chỗ\u003C\u002Fjats:italic>, bao gồm ba transporter nucleoside ở mức phiên mã mà thường trung gian việc vận chuyển adenosine qua màng tế bào. Tính thấm ước tính của các lớp tế bào này đối với adenosine [\u003Cjats:sup>14\u003C\u002Fjats:sup>C] là thấp và cùng cỡ với các dấu hiệu của khuếch tán ngoài tế bào.\u003Cjats:p>Tuy nhiên, sự ức chế các enzyme nội bào, adenosine kinase và adenosine deaminase, dẫn đến một sự gia tăng đáng kể trong tính thấm xuyên tế bào, cho thấy rằng phosphoryl hóa bên trong tế bào thành nucleotides có thể là lý do cho tính thấm xuyên tế bào thấp. Phân tích HPLC với việc phát hiện đồng thời phóng xạ cho thấy rằng phóng xạ [\u003Cjats:sup>14\u003C\u002Fjats:sup>C] xuất hiện trong buồng tiếp nhận sau khi nuôi cấy các lớp CPEC với adenosine [\u003Cjats:sup>14\u003C\u002Fjats:sup>C] trong buồng cho chủ yếu tồn tại dưới dạng hypoxanthine [\u003Cjats:sup>14\u003C\u002Fjats:sup>C], một sản phẩm phân hủy chuyển hóa của adenosine. Do đó, có vẻ như CPEC trong các nuôi cấy nguyên phát hoạt động như một rào cản enzym đối với adenosine. Các nghiên cứu về sự hấp thu tế bào cho thấy sự hấp thu tập trung của adenosine [\u003Cjats:sup>14\u003C\u002Fjats:sup>C] chỉ bị giới hạn ở phía của các tế bào này đối diện với buồng trên hoặc bề mặt, cho thấy sự phân bố không đồng đều của các transporter nucleoside.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>","\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>Efflux transport of adenosine across the choroid plexus (CP) epithelium might contribute to the homeostasis of this neuromodulator in the extracellular fluids of the brain. The aim of this study was to explore adenosine transport across sheep CP epithelial cell monolayers in primary culture.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Methods\u003C\u002Fjats:title>\n            \u003Cjats:p>To explore transport of adenosine across the CP epithelium, we have developed \u003Cjats:bold>a\u003C\u002Fjats:bold> method for primary culture of the sheep choroid plexus epithelial cells (CPEC) on plastic permeable supports and analysed [\u003Cjats:sup>14\u003C\u002Fjats:sup>C] adenosine transport across this cellular layer, [\u003Cjats:sup>14\u003C\u002Fjats:sup>C] adenosine metabolism inside the cells, and cellular uptake of [\u003Cjats:sup>14\u003C\u002Fjats:sup>C] adenosine from either of the chambers. The primary cell culture consisted of an enriched epithelial cell fraction from the sheep fourth ventricle CP and was grown on laminin-precoated filter inserts.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results and conclusion\u003C\u002Fjats:title>\n            \u003Cjats:p>CPEC grew as monolayers forming typical polygonal islands, reaching optical confluence on the third day after the seeding. Transepithelial electrical resistance increased over the time after seeding up to 85 ± 9 Ω cm\u003Cjats:sup>2\u003C\u002Fjats:sup> at day 8, while permeability towards [\u003Cjats:sup>14\u003C\u002Fjats:sup>C] sucrose, a marker of paracellular diffusion, simultaneously decreased. These cells expressed some features typical of the CPEC \u003Cjats:italic>in situ\u003C\u002Fjats:italic>, including three nucleoside transporters at the transcript level that normally mediate adenosine transport across cellular membranes. The estimated permeability of these monolayers towards [\u003Cjats:sup>14\u003C\u002Fjats:sup>C] adenosine was low and the same order of magnitude as for the markers of paracellular diffusion.\u003C\u002Fjats:p>\n            \u003Cjats:p>However, inhibition of the intracellular enzymes, adenosine kinase and adenosine deaminase, led to a significant increase in transcellular permeability, indicating that intracellular phosphorylation into nucleotides might be a reason for the low transcellular permeability. HPLC analysis with simultaneous detection of radioactivity revealed that [\u003Cjats:sup>14\u003C\u002Fjats:sup>C] radioactivity which appeared in the acceptor chamber after the incubation of CPEC monolayers with [\u003Cjats:sup>14\u003C\u002Fjats:sup>C] adenosine in the donor chamber was mostly present as [\u003Cjats:sup>14\u003C\u002Fjats:sup>C] hypoxanthine, a product of adenosine metabolic degradation. Therefore, it appears that CPEC in primary cultures act as an enzymatic barrier towards adenosine. Cellular uptake studies revealed that concentrative uptake of [\u003Cjats:sup>14\u003C\u002Fjats:sup>C] adenosine was confined only to the side of these cells facing the upper or apical chamber, indicating uneven distribution of nucleoside transporters.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"VI":2794,"EN":2795},"Phân bố không đồng đều của các transporter nucleoside và sự phân hủy enzym nội bào ngăn cản sự vận chuyển adenosine [14C] nguyên vẹn qua biểu mô màng đệm ở cừu dưới dạng một lớp tế bào trong nuôi cấy nguyên phát","Uneven distribution of nucleoside transporters and intracellular enzymatic degradation prevent transport of intact [14C] adenosine across the sheep choroid plexus epithelium as a monolayer in primary culture",{"VOID":2797},"16571111",{"VOID":2799},"10.1186\u002F1743-8454-3-4","2024-12-10T01:13:42.632+00:00",[102],[101],"https:\u002F\u002Ffluidsbarrierscns.biomedcentral.com\u002Farticles\u002F10.1186\u002F1743-8454-3-4",[2805,2825,2845,2862,2878],{"id":2806,"sortIndex":59,"researcher":26,"roles":2807,"affiliations":2808,"properties":2818},"2807a185-7480-4936-b7e1-3ae375f20f4e",[],[2809],{"id":26,"sortIndex":36,"affiliation":2810,"properties":26},{"id":2811,"createTime":2812,"updateTime":2812,"relativeEntities":2813,"slug":2814,"properties":2815,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"f34547b0-5a77-4af3-90c3-97f6f20b3b43","2024-04-12T02:18:30.312+00:00",[],"Department-of-Microbiology-School-of-Medicine-Belgrade-Serbia-Montenegro",{"title":2816},{"EN":2817},"Department of Microbiology, School of Medicine, Belgrade, Serbia & Montenegro",{"openalex":2819,"orcid":2821,"title":2823},{"VOID":2820},"A5003927956",{"VOID":2822},"https:\u002F\u002Forcid.org\u002F0000-0002-7502-1709",{"EN":2824},"Dušan Popadić",{"id":2826,"sortIndex":114,"researcher":26,"roles":2827,"affiliations":2828,"properties":2838},"f9d86bbd-7138-4eca-af00-45c5e4e1d59a",[],[2829],{"id":26,"sortIndex":36,"affiliation":2830,"properties":26},{"id":2831,"createTime":2832,"updateTime":2832,"relativeEntities":2833,"slug":2834,"properties":2835,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"2332e2ed-5b15-4a7c-b4e0-140c46a09f8f","2024-04-12T02:18:30.290+00:00",[],"Department-of-Biochemistry-School-of-Medicine-Belgrade-Serbia-Montenegro",{"title":2836},{"EN":2837},"Department of Biochemistry, School of Medicine, Belgrade, Serbia & Montenegro",{"openalex":2839,"orcid":2841,"title":2843},{"VOID":2840},"A5048084813",{"VOID":2842},"https:\u002F\u002Forcid.org\u002F0000-0002-8635-4701",{"EN":2844},"Sonja Misirlić-Denčić",{"id":2846,"sortIndex":111,"researcher":26,"roles":2847,"affiliations":2848,"properties":2857},"fedb25f7-16dc-4f9f-b5d5-3c8a42f245b3",[],[2849],{"id":26,"sortIndex":36,"affiliation":2850,"properties":26},{"id":2851,"createTime":2852,"updateTime":2852,"relativeEntities":2853,"slug":26,"properties":2854,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"93dd3df0-4987-473c-81db-45799430047d","2024-01-05T01:42:40.102+00:00",[],{"title":2855},{"VI":2856},"School of Biomedical Sciences, King's College London, London, UK",{"openalex":2858,"title":2860},{"VOID":2859},"A5059085607",{"EN":2861},"Malcolm B. Segal",{"id":2863,"sortIndex":115,"researcher":26,"roles":2864,"affiliations":2865,"properties":2871},"abf85972-e52f-40ba-96f3-7ccf278327e5",[],[2866],{"id":26,"sortIndex":36,"affiliation":2867,"properties":26},{"id":2831,"createTime":2832,"updateTime":2832,"relativeEntities":2868,"slug":2834,"properties":2869,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":2870},{"EN":2837},{"openalex":2872,"orcid":2874,"title":2876},{"VOID":2873},"A5055460002",{"VOID":2875},"https:\u002F\u002Forcid.org\u002F0000-0002-4132-6870",{"EN":2877},"Aleksandra Isaković",{"id":2879,"sortIndex":36,"researcher":26,"roles":2880,"affiliations":2881,"properties":2896},"72be3211-e6d5-43f2-92b9-b547cbc45a2f",[],[2882,2887],{"id":26,"sortIndex":36,"affiliation":2883,"properties":26},{"id":2851,"createTime":2852,"updateTime":2852,"relativeEntities":2884,"slug":26,"properties":2885,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":2886},{"VI":2856},{"id":26,"sortIndex":36,"affiliation":2888,"properties":26},{"id":2889,"createTime":2890,"updateTime":2890,"relativeEntities":2891,"slug":2892,"properties":2893,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"e96474ce-dd57-4d8e-ba76-ac26506a48c7","2024-04-12T02:18:30.227+00:00",[],"Department-of-Physiology-Faculty-of-Medicine-Kuwait-Kuwait",{"title":2894},{"EN":2895},"Department of Physiology, Faculty of Medicine, Kuwait, Kuwait",{"openalex":2897,"orcid":2899,"title":2901},{"VOID":2898},"A5006978499",{"VOID":2900},"https:\u002F\u002Forcid.org\u002F0000-0002-2968-5547",{"EN":2902},"Zoran Redzic",{"url":26,"publisher":2904,"properties":26},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":2905,"slug":663,"properties":2906,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":2909,"manageAffiliations":2910,"indexDatabases":2911,"url":672,"thumbnailPath":26,"statistic":2912,"gsStatistic":26,"type":175,"analyzePriority":26},[],{"issn":2907,"title":2908},{"VOID":666},{"EN":668},[],[],[],{"impactFactor":36,"impactFactorByYear":2913,"i10Index":50,"i10IndexLast5Year":36,"totalPublication":675,"totalPublicationByYear":2914,"totalCitation":678,"totalCitationByYear":2915,"totalCitationPerPublication":680,"totalCitationPerPublicationByYear":2916,"hindexLast5Year":50,"hindex":50},{"2012":341},{"2004":283,"2005":204,"2006":677,"2007":517,"2008":116,"2009":251,"2010":204},{"2005":111,"2006":282,"2007":59,"2008":569,"2009":627,"2010":286},{"2005":171,"2006":682,"2007":110,"2008":683,"2009":684,"2010":685},{"total":53,"publishYear":26,"statisticByYear":2918},{"2013":115,"2019":114},"2024-04-13T10:17:52.611+00:00",[2921,2925,2929,2933,2937,2941,2945,2949,2953,2956,2960,2964,2968,2971,2974,2977,2981,2984,2988,2992,2996,3000,3004,3008,3012,3016,3020,3024],{"id":26,"text":2922,"url":26,"identifiers":2923},"Von Lubitz DK: Adenosine and cerebral ischemia: therapeutic future or death of a brave concept?. 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