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other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. 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2011, Gut feelings: the emerging biology of gut-brain communication, Nat Rev Neurosci, 12, 453, 10.1038\u002Fnrn3071",{"doi":890},"10.1038\u002Fnrn3071",{"id":26,"text":892,"url":26,"identifiers":893},"Rhee, 2009, Principles and clinical implications of the brain-gut-enteric microbiota axis, Nat Rev Gastroenterol Hepatol, 6, 306, 10.1038\u002Fnrgastro.2009.35",{"doi":894},"10.1038\u002Fnrgastro.2009.35",{"id":26,"text":896,"url":26,"identifiers":897},"Cryan, 2012, Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour, Nat Rev Neurosci, 13, 701, 10.1038\u002Fnrn3346",{"doi":898},"10.1038\u002Fnrn3346",{"id":26,"text":900,"url":26,"identifiers":901},"Park, 2013, Altered colonic function and microbiota profile in a mouse model of chronic depression, Neurogastroenterol Motil, 25, 10.1111\u002Fnmo.12153",{"doi":902},"10.1111\u002Fnmo.12153",{"id":26,"text":904,"url":26,"identifiers":905},"Vuong, 2017, Emerging roles for the gut microbiome in autism spectrum disorder, Biol Psychiatry, 81, 411, 10.1016\u002Fj.biopsych.2016.08.024",{"doi":906},"10.1016\u002Fj.biopsych.2016.08.024",{"id":26,"text":908,"url":26,"identifiers":909},"Sampson, 2016, Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease, Cell, 167, 1469, 10.1016\u002Fj.cell.2016.11.018",{"doi":910},"10.1016\u002Fj.cell.2016.11.018",{"id":26,"text":912,"url":26,"identifiers":913},"Berer, 2011, Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination, Nature, 479, 538, 10.1038\u002Fnature10554",{"doi":914},"10.1038\u002Fnature10554",{"id":26,"text":916,"url":26,"identifiers":917},"Amaral, 2008, Commensal microbiota is fundamental for the development of inflammatory pain, Proc Natl Acad Sci U S A, 105, 2193, 10.1073\u002Fpnas.0711891105",{"doi":918},"10.1073\u002Fpnas.0711891105",{"id":26,"text":920,"url":26,"identifiers":921},"Bercik, 2011, The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice, Gastroenterology, 141, 599, 10.1053\u002Fj.gastro.2011.04.052",{"doi":922},"10.1053\u002Fj.gastro.2011.04.052",{"id":26,"text":924,"url":26,"identifiers":925},"Collins, 2013, The adoptive transfer of behavioral phenotype via the intestinal microbiota: experimental evidence and clinical implications, Curr Opin Microbiol, 16, 240, 10.1016\u002Fj.mib.2013.06.004",{"doi":926},"10.1016\u002Fj.mib.2013.06.004",{"id":26,"text":928,"url":26,"identifiers":929},"Desai, 2016, A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility, Cell, 167, 1339, 10.1016\u002Fj.cell.2016.10.043",{"doi":930},"10.1016\u002Fj.cell.2016.10.043",{"id":26,"text":932,"url":26,"identifiers":933},"Bowey, 2003, Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats, Food Chem Toxicol, 41, 631, 10.1016\u002FS0278-6915(02)00324-1",{"doi":934},"10.1016\u002FS0278-6915(02)00324-1",{"id":26,"text":936,"url":26,"identifiers":937},"Mallett, 1987, The use of rats associated with a human faecal flora as a model for studying the effects of diet on the human gut microflora, J Appl Bacteriol, 63, 39, 10.1111\u002Fj.1365-2672.1987.tb02415.x",{"doi":938},"10.1111\u002Fj.1365-2672.1987.tb02415.x",{"id":26,"text":940,"url":26,"identifiers":941},"Bellono, 2017, Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways, Cell, 170, 185, 10.1016\u002Fj.cell.2017.05.034",{"doi":942},"10.1016\u002Fj.cell.2017.05.034",{"id":26,"text":944,"url":26,"identifiers":945},"Yissachar, 2017, An intestinal organ culture system uncovers a role for the nervous system in microbe-immune crosstalk, Cell, 168, 1135, 10.1016\u002Fj.cell.2017.02.009",{"doi":946},"10.1016\u002Fj.cell.2017.02.009",{"id":26,"text":948,"url":26,"identifiers":949},"Bravo, 2011, Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve, Proc Natl Acad Sci U S A, 108, 16050, 10.1073\u002Fpnas.1102999108",{"doi":950},"10.1073\u002Fpnas.1102999108",{"id":26,"text":952,"url":26,"identifiers":953},"Sudo, 2004, Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice, J Physiol, 558, 263, 10.1113\u002Fjphysiol.2004.063388",{"doi":954},"10.1113\u002Fjphysiol.2004.063388",{"id":26,"text":956,"url":26,"identifiers":957},"Neufeld, 2011, Reduced anxiety-like behavior and central neurochemical change in germ-free mice, Neurogastroenterol Motil, 23, 255, 10.1111\u002Fj.1365-2982.2010.01620.x",{"doi":958},"10.1111\u002Fj.1365-2982.2010.01620.x",{"id":26,"text":960,"url":26,"identifiers":961},"Diaz Heijtz, 2011, Normal gut microbiota modulates brain development and behavior, Proc Natl Acad Sci U S A, 108, 3047, 10.1073\u002Fpnas.1010529108",{"doi":962},"10.1073\u002Fpnas.1010529108",{"id":26,"text":964,"url":26,"identifiers":965},"Desbonnet, 2010, Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression, Neuroscience, 170, 1179, 10.1016\u002Fj.neuroscience.2010.08.005",{"doi":966},"10.1016\u002Fj.neuroscience.2010.08.005",{"id":26,"text":968,"url":26,"identifiers":969},"Clarke, 2013, The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner, Mol Psychiatry, 18, 666, 10.1038\u002Fmp.2012.77",{"doi":970},"10.1038\u002Fmp.2012.77",{"id":26,"text":972,"url":26,"identifiers":973},"Bercik, 2011, The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication, Neurogastroenterol Motil, 23, 1132, 10.1111\u002Fj.1365-2982.2011.01796.x",{"doi":974},"10.1111\u002Fj.1365-2982.2011.01796.x",{"id":26,"text":976,"url":26,"identifiers":977},"Crumeyrolle-Arias, 2014, Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats, Psychoneuroendocrinology, 42, 207, 10.1016\u002Fj.psyneuen.2014.01.014",{"doi":978},"10.1016\u002Fj.psyneuen.2014.01.014",{"id":26,"text":980,"url":26,"identifiers":981},"Savignac, 2014, Bifidobacteria exert strain-specific effects on stress-related behavior and physiology in BALB\u002Fc mice, Neurogastroenterol Motil, 26, 1615, 10.1111\u002Fnmo.12427",{"doi":982},"10.1111\u002Fnmo.12427",{"id":26,"text":984,"url":26,"identifiers":985},"De Palma, 2015, Microbiota and host determinants of behavioural phenotype in maternally separated mice, Nat Commun, 6, 7735, 10.1038\u002Fncomms8735",{"doi":986},"10.1038\u002Fncomms8735",{"id":26,"text":988,"url":26,"identifiers":989},"Hsiao, 2013, Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders, Cell, 155, 1451, 10.1016\u002Fj.cell.2013.11.024",{"doi":990},"10.1016\u002Fj.cell.2013.11.024",{"id":26,"text":992,"url":26,"identifiers":993},"Kelly, 2016, Transferring the blues: depression-associated gut microbiota induces neurobehavioural changes in the rat, J Psychiatr Res, 82, 109, 10.1016\u002Fj.jpsychires.2016.07.019",{"doi":994},"10.1016\u002Fj.jpsychires.2016.07.019",{"id":26,"text":996,"url":26,"identifiers":997},"Desbonnet, 2015, Gut microbiota depletion from early adolescence in mice: implications for brain and behaviour, Brain Behav Immun, 48, 165, 10.1016\u002Fj.bbi.2015.04.004",{"doi":998},"10.1016\u002Fj.bbi.2015.04.004",{"id":26,"text":1000,"url":26,"identifiers":1001},"Schroeder, 2007, Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse, Biol Psychiatry, 62, 55, 10.1016\u002Fj.biopsych.2006.06.036",{"doi":1002},"10.1016\u002Fj.biopsych.2006.06.036",{"id":26,"text":1004,"url":26,"identifiers":1005},"Desbonnet, 2008, The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat, J Psychiatr Res, 43, 164, 10.1016\u002Fj.jpsychires.2008.03.009",{"doi":1006},"10.1016\u002Fj.jpsychires.2008.03.009",{"id":26,"text":1008,"url":26,"identifiers":1009},"Arseneault-Breard, 2012, Combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces post-myocardial infarction depression symptoms and restores intestinal permeability in a rat model, Br J Nutr, 107, 1793, 10.1017\u002FS0007114511005137",{"doi":1010},"10.1017\u002FS0007114511005137",{"id":26,"text":1012,"url":26,"identifiers":1013},"Zheng, 2016, Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism, Mol Psychiatry, 21, 786, 10.1038\u002Fmp.2016.44",{"doi":1014},"10.1038\u002Fmp.2016.44",{"id":26,"text":1016,"url":26,"identifiers":1017},"Ait-Belgnaoui, 2006, Lactobacillus farciminis treatment suppresses stress induced visceral hypersensitivity: a possible action through interaction with epithelial cell cytoskeleton contraction, Gut, 55, 1090, 10.1136\u002Fgut.2005.084194",{"doi":1018},"10.1136\u002Fgut.2005.084194",{"id":26,"text":1020,"url":26,"identifiers":1021},"Eutamene, 2007, Synergy between Lactobacillus paracasei and its bacterial products to counteract stress-induced gut permeability and sensitivity increase in rats, J Nutr, 137, 1901",{},{"id":26,"text":1023,"url":26,"identifiers":1024},"Rousseaux, 2007, Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors, Nat Med, 13, 35, 10.1038\u002Fnm1521",{"doi":1025},"10.1038\u002Fnm1521",{"id":26,"text":1027,"url":26,"identifiers":1028},"Ma, 2009, Lactobacillus reuteri ingestion prevents hyperexcitability of colonic DRG neurons induced by noxious stimuli, Am J Physiol Gastrointest Liver Physiol, 296, G868, 10.1152\u002Fajpgi.90511.2008",{"doi":1029},"10.1152\u002Fajpgi.90511.2008",{"id":26,"text":1031,"url":26,"identifiers":1032},"Kunze, 2009, Lactobacillus reuteri enhances excitability of colonic AH neurons by inhibiting calcium-dependent potassium channel opening, J Cell Mol Med, 13, 2261, 10.1111\u002Fj.1582-4934.2009.00686.x",{"doi":1033},"10.1111\u002Fj.1582-4934.2009.00686.x",{"id":26,"text":1035,"url":26,"identifiers":1036},"Duca, 2012, Increased oral detection, but decreased intestinal signaling for fats in mice lacking gut microbiota, PLoS One, 7, e39748, 10.1371\u002Fjournal.pone.0039748",{"doi":1037},"10.1371\u002Fjournal.pone.0039748",{"id":26,"text":1039,"url":26,"identifiers":1040},"Vijay-Kumar, 2010, Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5, Science, 328, 228, 10.1126\u002Fscience.1179721",{"doi":1041},"10.1126\u002Fscience.1179721",{"id":26,"text":1043,"url":26,"identifiers":1044},"Tanida, 2005, Effects of intraduodenal injection of Lactobacillus johnsonii La1 on renal sympathetic nerve activity and blood pressure in urethane-anesthetized rats, Neurosci Lett, 389, 109, 10.1016\u002Fj.neulet.2005.07.036",{"doi":1045},"10.1016\u002Fj.neulet.2005.07.036",{"id":26,"text":1047,"url":26,"identifiers":1048},"Mayer, 2015, Gut\u002Fbrain axis and the microbiota, J Clin Invest, 125, 926, 10.1172\u002FJCI76304",{"doi":1049},"10.1172\u002FJCI76304",{"id":26,"text":1051,"url":26,"identifiers":1052},"Mayer, 2014, Gut microbes and the brain: paradigm shift in neuroscience, J Neurosci, 34, 15490, 10.1523\u002FJNEUROSCI.3299-14.2014",{"doi":1053},"10.1523\u002FJNEUROSCI.3299-14.2014",{"id":26,"text":1055,"url":26,"identifiers":1056},"Bercik, 2012, Microbes and the gut-brain axis, Neurogastroenterol Motil, 24, 405, 10.1111\u002Fj.1365-2982.2012.01906.x",{"doi":1057},"10.1111\u002Fj.1365-2982.2012.01906.x",{"id":26,"text":1059,"url":26,"identifiers":1060},"Martin, 2017, Gut-brain axis and behavior, Nestle Nutr Inst Workshop Ser, 88, 45, 10.1159\u002F000461732",{"doi":1061},"10.1159\u002F000461732",{"id":26,"text":1063,"url":26,"identifiers":1064},"Sharon, 2016, The central nervous system and the gut microbiome, Cell, 167, 915, 10.1016\u002Fj.cell.2016.10.027",{"doi":1065},"10.1016\u002Fj.cell.2016.10.027",{"id":26,"text":1067,"url":26,"identifiers":1068},"Grill, 2011, Neurotoxic effects associated with antibiotic use: management considerations, Br J Clin Pharmacol, 72, 381, 10.1111\u002Fj.1365-2125.2011.03991.x",{"doi":1069},"10.1111\u002Fj.1365-2125.2011.03991.x",{"id":26,"text":1071,"url":26,"identifiers":1072},"Mohle, 2016, Ly6C(hi) monocytes provide a link between antibiotic-induced changes in gut microbiota and adult hippocampal neurogenesis, Cell Rep, 15, 1945, 10.1016\u002Fj.celrep.2016.04.074",{"doi":1073},"10.1016\u002Fj.celrep.2016.04.074",{"id":26,"text":1075,"url":26,"identifiers":1076},"Messaoudi, 2011, Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects, Br J Nutr, 105, 755, 10.1017\u002FS0007114510004319",{"doi":1077},"10.1017\u002FS0007114510004319",{"id":26,"text":1079,"url":26,"identifiers":1080},"Kantak, 2014, Obsessive-compulsive-like behaviors in house mice are attenuated by a probiotic (Lactobacillus rhamnosus GG), Behav Pharmacol, 25, 71, 10.1097\u002FFBP.0000000000000013",{"doi":1081},"10.1097\u002FFBP.0000000000000013",{"id":26,"text":1083,"url":26,"identifiers":1084},"D'Mello, 2015, Probiotics improve inflammation-associated sickness behavior by altering communication between the peripheral immune system and the brain, J Neurosci, 35, 10821, 10.1523\u002FJNEUROSCI.0575-15.2015",{"doi":1085},"10.1523\u002FJNEUROSCI.0575-15.2015",{"id":26,"text":1087,"url":26,"identifiers":1088},"Cowan, 2016, The effects of a probiotic formulation (Lactobacillus rhamnosus and L. helveticus) on developmental trajectories of emotional learning in stressed infant rats, Transl Psychiatry, 6, e823, 10.1038\u002Ftp.2016.94",{"doi":1089},"10.1038\u002Ftp.2016.94",{"id":26,"text":1091,"url":26,"identifiers":1092},"David, 2014, Diet rapidly and reproducibly alters the human gut microbiome, Nature, 505, 559, 10.1038\u002Fnature12820",{"doi":1093},"10.1038\u002Fnature12820",{"id":26,"text":1095,"url":26,"identifiers":1096},"Carmody, 2015, Diet dominates host genotype in shaping the murine gut microbiota, Cell Host Microbe, 17, 72, 10.1016\u002Fj.chom.2014.11.010",{"doi":1097},"10.1016\u002Fj.chom.2014.11.010",{"id":26,"text":1099,"url":26,"identifiers":1100},"Turnbaugh, 2009, The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice, Sci Transl Med, 1, 6ra14, 10.1126\u002Fscitranslmed.3000322",{"doi":1101},"10.1126\u002Fscitranslmed.3000322",{"id":26,"text":1103,"url":26,"identifiers":1104},"Li, 2009, Memory and learning behavior in mice is temporally associated with diet-induced alterations in gut bacteria, Physiol Behav, 96, 557, 10.1016\u002Fj.physbeh.2008.12.004",{"doi":1105},"10.1016\u002Fj.physbeh.2008.12.004",{"id":26,"text":1107,"url":26,"identifiers":1108},"Jorgensen, 2014, A possible link between food and mood: dietary impact on gut microbiota and behavior in BALB\u002Fc mice, PLoS One, 9, e103398, 10.1371\u002Fjournal.pone.0103398",{"doi":1109},"10.1371\u002Fjournal.pone.0103398",{"id":26,"text":1111,"url":26,"identifiers":1112},"Beilharz, 2018, Cafeteria diet and probiotic therapy: cross talk among memory, neuroplasticity, serotonin receptors and gut microbiota in the rat, Mol Psychiatry, 23, 351, 10.1038\u002Fmp.2017.38",{"doi":1113},"10.1038\u002Fmp.2017.38",{"id":26,"text":1115,"url":26,"identifiers":1116},"Pinto-Sanchez, 2017, Probiotic Bifidobacterium longum NCC3001 reduces depression scores and alters brain activity: a pilot study in patients with irritable bowel syndrome, Gastroenterology, 153, 448, 10.1053\u002Fj.gastro.2017.05.003",{"doi":1117},"10.1053\u002Fj.gastro.2017.05.003",{"id":26,"text":1119,"url":26,"identifiers":1120},"Tillisch, 2013, Consumption of fermented milk product with probiotic modulates brain activity, Gastroenterology, 144, 1394, 10.1053\u002Fj.gastro.2013.02.043",{"doi":1121},"10.1053\u002Fj.gastro.2013.02.043",{"id":26,"text":1123,"url":26,"identifiers":1124},"Steenbergen, 2015, A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood, Brain Behav Immun, 48, 258, 10.1016\u002Fj.bbi.2015.04.003",{"doi":1125},"10.1016\u002Fj.bbi.2015.04.003",{"id":26,"text":1127,"url":26,"identifiers":1128},"Messaoudi, 2011, Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers, Gut Microbes, 2, 256, 10.4161\u002Fgmic.2.4.16108",{"doi":1129},"10.4161\u002Fgmic.2.4.16108",{"id":26,"text":1131,"url":26,"identifiers":1132},"Kelly, 2017, Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects, Brain Behav Immun, 61, 50, 10.1016\u002Fj.bbi.2016.11.018",{"doi":1133},"10.1016\u002Fj.bbi.2016.11.018",{"id":26,"text":1135,"url":26,"identifiers":1136},"Meyer, 2018, The fragility of probiotic Bifidobacterium longum NCC3001 use for depression in patients with irritable bowel syndrome, Gastroenterology, 154, 764, 10.1053\u002Fj.gastro.2017.09.055",{"doi":1137},"10.1053\u002Fj.gastro.2017.09.055",{"id":26,"text":1139,"url":26,"identifiers":1140},"McNulty, 2011, The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins, Sci Transl Med, 3, 106ra106, 10.1126\u002Fscitranslmed.3002701",{"doi":1141},"10.1126\u002Fscitranslmed.3002701",{"id":26,"text":1143,"url":26,"identifiers":1144},"Tolhurst, 2012, Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2, Diabetes, 61, 364, 10.2337\u002Fdb11-1019",{"doi":1145},"10.2337\u002Fdb11-1019",{"id":26,"text":1147,"url":26,"identifiers":1148},"Wang, 2014, An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signalling, Nat Commun, 5, 4432, 10.1038\u002Fncomms5432",{"doi":1149},"10.1038\u002Fncomms5432",{"id":26,"text":1151,"url":26,"identifiers":1152},"Singh, 2016, Microbiota dysbiosis controls the neuroinflammatory response after stroke, J Neurosci, 36, 7428, 10.1523\u002FJNEUROSCI.1114-16.2016",{"doi":1153},"10.1523\u002FJNEUROSCI.1114-16.2016",{"id":26,"text":1155,"url":26,"identifiers":1156},"Yano, 2015, Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis, Cell, 161, 264, 10.1016\u002Fj.cell.2015.02.047",{"doi":1157},"10.1016\u002Fj.cell.2015.02.047",{"id":26,"text":1159,"url":26,"identifiers":1160},"Wikoff, 2009, Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites, Proc Natl Acad Sci U S A, 106, 3698, 10.1073\u002Fpnas.0812874106",{"doi":1161},"10.1073\u002Fpnas.0812874106",{"id":26,"text":1163,"url":26,"identifiers":1164},"Samuel, 2008, Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41, Proc Natl Acad Sci U S A, 105, 16767, 10.1073\u002Fpnas.0808567105",{"doi":1165},"10.1073\u002Fpnas.0808567105",{"id":26,"text":1167,"url":26,"identifiers":1168},"Haghikia, 2015, Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine, Immunity, 43, 817, 10.1016\u002Fj.immuni.2015.09.007",{"doi":1169},"10.1016\u002Fj.immuni.2015.09.007",{"id":26,"text":1171,"url":26,"identifiers":1172},"Goehler, 2005, Activation in vagal afferents and central autonomic pathways: early responses to intestinal infection with Campylobacter jejuni, Brain Behav Immun, 19, 334, 10.1016\u002Fj.bbi.2004.09.002",{"doi":1173},"10.1016\u002Fj.bbi.2004.09.002",{"id":26,"text":1175,"url":26,"identifiers":1176},"Barrett, 2012, gamma-Aminobutyric acid production by culturable bacteria from the human intestine, J Appl Microbiol, 113, 411, 10.1111\u002Fj.1365-2672.2012.05344.x",{"doi":1177},"10.1111\u002Fj.1365-2672.2012.05344.x",{"id":26,"text":1179,"url":26,"identifiers":1180},"Minuk, 1986, Gamma-aminobutyric-acid (Gaba) production by 8 common bacterial pathogens, Scand J Infect Dis, 18, 465, 10.3109\u002F00365548609032366",{"doi":1181},"10.3109\u002F00365548609032366",{"id":26,"text":1183,"url":26,"identifiers":1184},"Ozogul, 2011, Effects of specific lactic acid bacteria species on biogenic amine production by foodborne pathogen, Int J Food Sci Tech, 46, 478, 10.1111\u002Fj.1365-2621.2010.02511.x",{"doi":1185},"10.1111\u002Fj.1365-2621.2010.02511.x",{"id":26,"text":1187,"url":26,"identifiers":1188},"Shishov, 2009, Amine neuromediators, their precursors, and oxidation products in the culture of Escherichia coli K-12, Appl Biochem Micro, 45, 494, 10.1134\u002FS0003683809050068",{"doi":1189},"10.1134\u002FS0003683809050068",{"id":26,"text":1191,"url":26,"identifiers":1192},"Asano, 2012, Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice, Am J Physiol Gastrointest Liver Physiol, 303, G1288, 10.1152\u002Fajpgi.00341.2012",{"doi":1193},"10.1152\u002Fajpgi.00341.2012",{"id":26,"text":1195,"url":26,"identifiers":1196},"Furness, 2013, The gut as a sensory organ, Nat Rev Gastroenterol Hepatol, 10, 729, 10.1038\u002Fnrgastro.2013.180",{"doi":1197},"10.1038\u002Fnrgastro.2013.180",{"id":26,"text":1199,"url":26,"identifiers":1200},"Morton, 2014, Carbohydrate feeding dissociates the postprandial FGF19 response from circulating bile acid levels in humans, J Clin Endocrinol Metab, 99, E241, 10.1210\u002Fjc.2013-3129",{"doi":1201},"10.1210\u002Fjc.2013-3129",{"id":26,"text":1203,"url":26,"identifiers":1204},"de Aguiar Vallim, 2013, Pleiotropic roles of bile acids in metabolism, Cell Metab, 17, 657, 10.1016\u002Fj.cmet.2013.03.013",{"doi":1205},"10.1016\u002Fj.cmet.2013.03.013",{"id":26,"text":1207,"url":26,"identifiers":1208},"Wahlstrom, 2016, Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism, Cell Metab, 24, 41, 10.1016\u002Fj.cmet.2016.05.005",{"doi":1209},"10.1016\u002Fj.cmet.2016.05.005",{"id":26,"text":1211,"url":26,"identifiers":1212},"Hsuchou, 2013, Fibroblast growth factor 19 entry into brain, Fluids Barriers CNS, 10, 32, 10.1186\u002F2045-8118-10-32",{"doi":1213},"10.1186\u002F2045-8118-10-32",{"id":26,"text":1215,"url":26,"identifiers":1216},"Marcelin, 2014, Central action of FGF19 reduces hypothalamic AGRP\u002FNPY neuron activity and improves glucose metabolism, Mol Metab, 3, 19, 10.1016\u002Fj.molmet.2013.10.002",{"doi":1217},"10.1016\u002Fj.molmet.2013.10.002",{"id":26,"text":1219,"url":26,"identifiers":1220},"Tomlinson, 2002, Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity, Endocrinology, 143, 1741, 10.1210\u002Fendo.143.5.8850",{"doi":1221},"10.1210\u002Fendo.143.5.8850",{"id":26,"text":1223,"url":26,"identifiers":1224},"Fu, 2004, Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes, Endocrinology, 145, 2594, 10.1210\u002Fen.2003-1671",{"doi":1225},"10.1210\u002Fen.2003-1671",{"id":26,"text":1227,"url":26,"identifiers":1228},"Ryan, 2013, Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats, Endocrinology, 154, 9, 10.1210\u002Fen.2012-1891",{"doi":1229},"10.1210\u002Fen.2012-1891",{"id":26,"text":1231,"url":26,"identifiers":1232},"Perry, 2015, FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis, Nat Commun, 6, 6980, 10.1038\u002Fncomms7980",{"doi":1233},"10.1038\u002Fncomms7980",{"id":26,"text":1235,"url":26,"identifiers":1236},"Maruyama, 2002, Identification of membrane-type receptor for bile acids (M-BAR), Biochem Biophys Res Commun, 298, 714, 10.1016\u002FS0006-291X(02)02550-0",{"doi":1237},"10.1016\u002FS0006-291X(02)02550-0",{"id":26,"text":1239,"url":26,"identifiers":1240},"Ridlon, 2006, Bile salt biotransformations by human intestinal bacteria, J Lipid Res, 47, 241, 10.1194\u002Fjlr.R500013-JLR200",{"doi":1241},"10.1194\u002Fjlr.R500013-JLR200",{"id":26,"text":1243,"url":26,"identifiers":1244},"Thomas, 2009, TGR5-mediated bile acid sensing controls glucose homeostasis, Cell Metab, 10, 167, 10.1016\u002Fj.cmet.2009.08.001",{"doi":1245},"10.1016\u002Fj.cmet.2009.08.001",{"id":26,"text":1247,"url":26,"identifiers":1248},"Trabelsi, 2015, Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells, Nat Commun, 6, 7629, 10.1038\u002Fncomms8629",{"doi":1249},"10.1038\u002Fncomms8629",{"id":26,"text":1251,"url":26,"identifiers":1252},"Topping, 2001, Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides, Physiol Rev, 81, 1031, 10.1152\u002Fphysrev.2001.81.3.1031",{"doi":1253},"10.1152\u002Fphysrev.2001.81.3.1031",{"id":26,"text":1255,"url":26,"identifiers":1256},"Russell, 2011, High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health, Am J Clin Nutr, 93, 1062, 10.3945\u002Fajcn.110.002188",{"doi":1257},"10.3945\u002Fajcn.110.002188",{"id":26,"text":1259,"url":26,"identifiers":1260},"Cani, 2009, Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal, Am J Clin Nutr, 90, 1236, 10.3945\u002Fajcn.2009.28095",{"doi":1261},"10.3945\u002Fajcn.2009.28095",{"id":26,"text":1263,"url":26,"identifiers":1264},"Nohr, 2015, Expression of the short chain fatty acid receptor GPR41\u002FFFAR3 in autonomic and somatic sensory ganglia, Neuroscience, 290, 126, 10.1016\u002Fj.neuroscience.2015.01.040",{"doi":1265},"10.1016\u002Fj.neuroscience.2015.01.040",{"id":26,"text":1267,"url":26,"identifiers":1268},"Kim, 2000, Serotonin: a mediator of the brain-gut connection, Am J Gastroenterol, 95, 2698, 10.1111\u002Fj.1572-0241.2000.03177.x",{"doi":1269},"10.1111\u002Fj.1572-0241.2000.03177.x",{"id":26,"text":1271,"url":26,"identifiers":1272},"Ruddick, 2006, Tryptophan metabolism in the central nervous system: medical implications, Exp Rev Mol Med, 8, 1, 10.1017\u002FS1462399406000068",{"doi":1273},"10.1017\u002FS1462399406000068",{"id":26,"text":1275,"url":26,"identifiers":1276},"Marin, 2017, Microbiota alteration is associated with the development of stress-induced despair behavior, Sci Rep, 7, 43859, 10.1038\u002Fsrep43859",{"doi":1277},"10.1038\u002Fsrep43859",{"id":26,"text":1279,"url":26,"identifiers":1280},"Fung, 2017, Interactions between the microbiota, immune and nervous systems in health and disease, Nat Neurosci, 20, 145, 10.1038\u002Fnn.4476",{"doi":1281},"10.1038\u002Fnn.4476",{"id":26,"text":1283,"url":26,"identifiers":1284},"Ochoa-Reparaz, 2010, Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression, J Immunol, 185, 4101, 10.4049\u002Fjimmunol.1001443",{"doi":1285},"10.4049\u002Fjimmunol.1001443",{"id":26,"text":1287,"url":26,"identifiers":1288},"Ochoa-Reparaz, 2009, Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis, J Immunol, 183, 6041, 10.4049\u002Fjimmunol.0900747",{"doi":1289},"10.4049\u002Fjimmunol.0900747",{"id":26,"text":1291,"url":26,"identifiers":1292},"Benakis, 2016, Commensal microbiota affects ischemic stroke outcome by regulating intestinal gammadelta T cells, Nat Med, 22, 516, 10.1038\u002Fnm.4068",{"doi":1293},"10.1038\u002Fnm.4068",{"id":26,"text":1295,"url":26,"identifiers":1296},"Winek, 2016, Depletion of cultivatable gut microbiota by broad-spectrum antibiotic pretreatment worsens outcome after murine stroke, Stroke, 47, 1354, 10.1161\u002FSTROKEAHA.115.011800",{"doi":1297},"10.1161\u002FSTROKEAHA.115.011800",{"id":26,"text":1299,"url":26,"identifiers":1300},"Erny, 2015, Host microbiota constantly control maturation and function of microglia in the CNS, Nat Neurosci, 18, 965, 10.1038\u002Fnn.4030",{"doi":1301},"10.1038\u002Fnn.4030",{"id":26,"text":1303,"url":26,"identifiers":1304},"de Lartigue, 2011, Vagal afferent neurons in high fat diet-induced obesity; intestinal microflora, gut inflammation and cholecystokinin, Physiol Behav, 105, 100, 10.1016\u002Fj.physbeh.2011.02.040",{"doi":1305},"10.1016\u002Fj.physbeh.2011.02.040",{"id":26,"text":1307,"url":26,"identifiers":1308},"Barajon, 2009, Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia, J Histochem Cytochem, 57, 1013, 10.1369\u002Fjhc.2009.953539",{"doi":1309},"10.1369\u002Fjhc.2009.953539",{"id":26,"text":1311,"url":26,"identifiers":1312},"Brun, 2013, Toll-like receptor 2 regulates intestinal inflammation by controlling integrity of the enteric nervous system, Gastroenterology, 145, 1323, 10.1053\u002Fj.gastro.2013.08.047",{"doi":1313},"10.1053\u002Fj.gastro.2013.08.047",{"id":26,"text":1315,"url":26,"identifiers":1316},"Mao, 2013, Bacteroides fragilis polysaccharide A is necessary and sufficient for acute activation of intestinal sensory neurons, Nat Commun, 4, 1465, 10.1038\u002Fncomms2478",{"doi":1317},"10.1038\u002Fncomms2478",{"id":26,"text":1319,"url":26,"identifiers":1320},"Keita, 2010, The intestinal barrier and its regulation by neuroimmune factors, Neurogastroenterol Motil, 22, 718, 10.1111\u002Fj.1365-2982.2010.01498.x",{"doi":1321},"10.1111\u002Fj.1365-2982.2010.01498.x",{"id":26,"text":1323,"url":26,"identifiers":1324},"Huang, 2016, Identification of functional farnesoid X receptors in brain neurons, FEBS Lett, 590, 3233, 10.1002\u002F1873-3468.12373",{"doi":1325},"10.1002\u002F1873-3468.12373",{"id":26,"text":1327,"url":26,"identifiers":1328},"Keitel, 2010, The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain, Glia, 58, 1794, 10.1002\u002Fglia.21049",{"doi":1329},"10.1002\u002Fglia.21049",{"id":26,"text":1331,"url":26,"identifiers":1332},"Kimura, 2011, Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41), Proc Natl Acad Sci U S A, 108, 8030, 10.1073\u002Fpnas.1016088108",{"doi":1333},"10.1073\u002Fpnas.1016088108",{"id":26,"text":1335,"url":26,"identifiers":1336},"Won, 2013, beta-Hydroxybutyrate modulates N-type calcium channels in rat sympathetic neurons by acting as an agonist for the G-protein-coupled receptor FFA3, J Neurosci, 33, 19314, 10.1523\u002FJNEUROSCI.3102-13.2013",{"doi":1337},"10.1523\u002FJNEUROSCI.3102-13.2013",{"id":26,"text":1339,"url":26,"identifiers":1340},"Nohr, 2013, GPR41\u002FFFAR3 and GPR43\u002FFFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes, Endocrinology, 154, 3552, 10.1210\u002Fen.2013-1142",{"doi":1341},"10.1210\u002Fen.2013-1142",{"id":26,"text":1343,"url":26,"identifiers":1344},"Kelly, 2015, Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders, Front Cell Neurosci, 9, 392, 10.3389\u002Ffncel.2015.00392",{"doi":1345},"10.3389\u002Ffncel.2015.00392",{"id":26,"text":1347,"url":26,"identifiers":1348},"Ivanov, 2009, Induction of intestinal Th17 cells by segmented filamentous bacteria, Cell, 139, 485, 10.1016\u002Fj.cell.2009.09.033",{"doi":1349},"10.1016\u002Fj.cell.2009.09.033",{"id":26,"text":1351,"url":26,"identifiers":1352},"Round, 2011, The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota, Science, 332, 974, 10.1126\u002Fscience.1206095",{"doi":1353},"10.1126\u002Fscience.1206095",{"id":26,"text":1355,"url":26,"identifiers":1356},"Kucharzik, 2000, Role of M cells in intestinal barrier function, Ann N Y Acad Sci, 915, 171, 10.1111\u002Fj.1749-6632.2000.tb05240.x",{"doi":1357},"10.1111\u002Fj.1749-6632.2000.tb05240.x",{"id":26,"text":1359,"url":26,"identifiers":1360},"Vaishnava, 2008, Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface, Proc Natl Acad Sci U S A, 105, 20858, 10.1073\u002Fpnas.0808723105",{"doi":1361},"10.1073\u002Fpnas.0808723105",{"id":26,"text":1363,"url":26,"identifiers":1364},"Hooper, 2001, Molecular analysis of commensal host-microbial relationships in the intestine, Science, 291, 881, 10.1126\u002Fscience.291.5505.881",{"doi":1365},"10.1126\u002Fscience.291.5505.881",{"id":26,"text":1367,"url":26,"identifiers":1368},"Rakoff-Nahoum, 2004, Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis, Cell, 118, 229, 10.1016\u002Fj.cell.2004.07.002",{"doi":1369},"10.1016\u002Fj.cell.2004.07.002",{"id":26,"text":1371,"url":26,"identifiers":1372},"Da Silva, 2014, Stress disrupts intestinal mucus barrier in rats via mucin O-glycosylation shift: prevention by a probiotic treatment, Am J Physiol Gastrointest Liver Physiol, 307, G420, 10.1152\u002Fajpgi.00290.2013",{"doi":1373},"10.1152\u002Fajpgi.00290.2013",{"id":26,"text":1375,"url":26,"identifiers":1376},"Atuma, 2001, The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo, Am J Physiol Gastrointest Liver Physiol, 280, G922, 10.1152\u002Fajpgi.2001.280.5.G922",{"doi":1377},"10.1152\u002Fajpgi.2001.280.5.G922",{"id":26,"text":1379,"url":26,"identifiers":1380},"Macfarlane, 2007, Microbial biofilms in the human gastrointestinal tract, J Appl Microbiol, 102, 1187, 10.1111\u002Fj.1365-2672.2007.03287.x",{"doi":1381},"10.1111\u002Fj.1365-2672.2007.03287.x",{"id":26,"text":1383,"url":26,"identifiers":1384},"Johansson, 2011, The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions, Proc Natl Acad Sci U S A, 108, 4659, 10.1073\u002Fpnas.1006451107",{"doi":1385},"10.1073\u002Fpnas.1006451107",{"id":26,"text":1387,"url":26,"identifiers":1388},"Braniste, 2014, The gut microbiota influences blood-brain barrier permeability in mice, Sci Transl Med, 6, 263ra158, 10.1126\u002Fscitranslmed.3009759",{"doi":1389},"10.1126\u002Fscitranslmed.3009759",{"id":26,"text":1391,"url":26,"identifiers":1392},"Brown, 2003, The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids, J Biol Chem, 278, 11312, 10.1074\u002Fjbc.M211609200",{"doi":1393},"10.1074\u002Fjbc.M211609200",{"id":26,"text":1395,"url":26,"identifiers":1396},"Michel, 2016, One more role for the gut: microbiota and blood brain barrier, Ann Transl Med, 4, 15",{},{"id":26,"text":1398,"url":26,"identifiers":1399},"Varatharaj, 2017, The blood-brain barrier in systemic inflammation, Brain Behav Immun, 60, 1, 10.1016\u002Fj.bbi.2016.03.010",{"doi":1400},"10.1016\u002Fj.bbi.2016.03.010",{"id":26,"text":1402,"url":26,"identifiers":1403},"Aguilera, 2013, Stress and antibiotics alter luminal and wall-adhered microbiota and enhance the local expression of visceral sensory-related systems in mice, Neurogastroenterol Motil, 25, e515, 10.1111\u002Fnmo.12154",{"doi":1404},"10.1111\u002Fnmo.12154",{"id":26,"text":1406,"url":26,"identifiers":1407},"Tannock, 1974, Influences of dietary and environmental stress on microbial populations in the murine gastrointestinal tract, Infect Immun, 9, 591, 10.1128\u002FIAI.9.3.591-598.1974",{"doi":1408},"10.1128\u002FIAI.9.3.591-598.1974",{"id":26,"text":1410,"url":26,"identifiers":1411},"Galley, 2014, Exposure to a social stressor disrupts the community structure of the colonic mucosa-associated microbiota, BMC Microbiol, 14, 189, 10.1186\u002F1471-2180-14-189",{"doi":1412},"10.1186\u002F1471-2180-14-189",{"id":26,"text":1414,"url":26,"identifiers":1415},"Zijlmans, 2015, Maternal prenatal stress is associated with the infant intestinal microbiota, Psychoneuroendocrinology, 53, 233, 10.1016\u002Fj.psyneuen.2015.01.006",{"doi":1416},"10.1016\u002Fj.psyneuen.2015.01.006",{"id":26,"text":1418,"url":26,"identifiers":1419},"Van Felius, 2003, Interdigestive small bowel motility and duodenal bacterial overgrowth in experimental acute pancreatitis, Neurogastroenterol Motil, 15, 267, 10.1046\u002Fj.1365-2982.2003.00410.x",{"doi":1420},"10.1046\u002Fj.1365-2982.2003.00410.x",{"id":26,"text":1422,"url":26,"identifiers":1423},"Lewis, 1997, Stool form scale as a useful guide to intestinal transit time, Scand J Gastroenterol, 32, 920, 10.3109\u002F00365529709011203",{"doi":1424},"10.3109\u002F00365529709011203",{"id":26,"text":1426,"url":26,"identifiers":1427},"Saad, 2010, Do stool form and frequency correlate with whole-gut and colonic transit? Results from a multicenter study in constipated individuals and healthy controls, Am J Gastroenterol, 105, 403, 10.1038\u002Fajg.2009.612",{"doi":1428},"10.1038\u002Fajg.2009.612",{"id":26,"text":1430,"url":26,"identifiers":1431},"Vandeputte, 2016, Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates, Gut, 65, 57, 10.1136\u002Fgutjnl-2015-309618",{"doi":1432},"10.1136\u002Fgutjnl-2015-309618",{"id":26,"text":1434,"url":26,"identifiers":1435},"Falony, 2016, Population-level analysis of gut microbiome variation, Science, 352, 560, 10.1126\u002Fscience.aad3503",{"doi":1436},"10.1126\u002Fscience.aad3503",{"id":26,"text":1438,"url":26,"identifiers":1439},"Roager, 2016, Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut, Nat Microbiol, 1, 16093, 10.1038\u002Fnmicrobiol.2016.93",{"doi":1440},"10.1038\u002Fnmicrobiol.2016.93",{"id":26,"text":1442,"url":26,"identifiers":1443},"Tottey, 2017, Colonic transit time is a driven force of the gut microbiota composition and metabolism: in vitro evidence, J Neurogastroenterol Motil, 23, 124, 10.5056\u002Fjnm16042",{"doi":1444},"10.5056\u002Fjnm16042",{"id":26,"text":1446,"url":26,"identifiers":1447},"Santos, 2001, Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat, Gut, 48, 630, 10.1136\u002Fgut.48.5.630",{"doi":1448},"10.1136\u002Fgut.48.5.630",{"id":26,"text":1450,"url":26,"identifiers":1451},"Saunders, 2002, Physical and psychological stress in rats enhances colonic epithelial permeability via peripheral CRH, Dig Dis Sci, 47, 208, 10.1023\u002FA:1013204612762",{"doi":1452},"10.1023\u002FA:1013204612762",{"id":26,"text":1454,"url":26,"identifiers":1455},"Meddings, 2000, Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat, Gastroenterology, 119, 1019, 10.1053\u002Fgast.2000.18152",{"doi":1456},"10.1053\u002Fgast.2000.18152",{"id":26,"text":1458,"url":26,"identifiers":1459},"Demaude, 2006, Phenotypic changes in colonocytes following acute stress or activation of mast cells in mice: implications for delayed epithelial barrier dysfunction, Gut, 55, 655, 10.1136\u002Fgut.2005.078675",{"doi":1460},"10.1136\u002Fgut.2005.078675",{"id":26,"text":1462,"url":26,"identifiers":1463},"Lauffer, 2016, Subacute stress and chronic stress interact to decrease intestinal barrier function in rats, Stress, 19, 225, 10.3109\u002F10253890.2016.1154527",{"doi":1464},"10.3109\u002F10253890.2016.1154527",{"id":26,"text":1466,"url":26,"identifiers":1467},"Varghese, 2006, Antidepressants attenuate increased susceptibility to colitis in a murine model of depression, Gastroenterology, 130, 1743, 10.1053\u002Fj.gastro.2006.02.007",{"doi":1468},"10.1053\u002Fj.gastro.2006.02.007",{"id":26,"text":1470,"url":26,"identifiers":1471},"Rubio, 1992, Quantification of the sulphomucin-producing cell population of the colonic mucosa during protracted stress in rats, In Vivo, 6, 81",{},{"id":26,"text":1473,"url":26,"identifiers":1474},"Soderholm, 2002, Chronic stress induces mast cell-dependent bacterial adherence and initiates mucosal inflammation in rat intestine, Gastroenterology, 123, 1099, 10.1053\u002Fgast.2002.36019",{"doi":1475},"10.1053\u002Fgast.2002.36019",{"id":26,"text":1477,"url":26,"identifiers":1478},"Houlden, 2016, Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production, Brain Behav Immun, 57, 10, 10.1016\u002Fj.bbi.2016.04.003",{"doi":1479},"10.1016\u002Fj.bbi.2016.04.003",{"id":26,"text":1481,"url":26,"identifiers":1482},"Kim, 2010, Intestinal goblet cells and mucins in health and disease: recent insights and progress, Curr Gastroenterol Rep, 12, 319, 10.1007\u002Fs11894-010-0131-2",{"doi":1483},"10.1007\u002Fs11894-010-0131-2",{"id":26,"text":1485,"url":26,"identifiers":1486},"Lyte, 1993, The role of microbial endocrinology in infectious disease, J Endocrinol, 137, 343, 10.1677\u002Fjoe.0.1370343",{"doi":1487},"10.1677\u002Fjoe.0.1370343",{"id":26,"text":1489,"url":26,"identifiers":1490},"Mayer, 2014, Brain-gut microbiome interactions and functional bowel disorders, Gastroenterology, 146, 1500, 10.1053\u002Fj.gastro.2014.02.037",{"doi":1491},"10.1053\u002Fj.gastro.2014.02.037",{"id":26,"text":1493,"url":26,"identifiers":1494},"Santos, 1998, Release of mast cell mediators into the jejunum by cold pain stress in humans, Gastroenterology, 114, 640, 10.1016\u002FS0016-5085(98)70577-3",{"doi":1495},"10.1016\u002FS0016-5085(98)70577-3",{"id":26,"text":1497,"url":26,"identifiers":1498},"Stephens, 1989, Intracisternal injection of a TRH analogue stimulates gastric luminal serotonin release in rats, Am J Physiol, 256, G377",{},{"id":26,"text":1500,"url":26,"identifiers":1501},"Yang, 1992, TRH analogue microinjected into specific medullary nuclei stimulates gastric serotonin secretion in rats, Am J Physiol, 262, G216",{},{"id":26,"text":1503,"url":26,"identifiers":1504},"Clarke, 2006, The QseC sensor kinase: a bacterial adrenergic receptor, Proc Natl Acad Sci U S A, 103, 10420, 10.1073\u002Fpnas.0604343103",{"doi":1505},"10.1073\u002Fpnas.0604343103",{"id":26,"text":1507,"url":26,"identifiers":1508},"Lyte, 1992, The role of catecholamines in gram-negative sepsis, Med Hypotheses, 37, 255, 10.1016\u002F0306-9877(92)90197-K",{"doi":1509},"10.1016\u002F0306-9877(92)90197-K",{"id":26,"text":1511,"url":26,"identifiers":1512},"Alverdy, 2000, Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: evidence for in vivo virulence expression in Pseudomonas aeruginosa, Ann Surg, 232, 480, 10.1097\u002F00000658-200010000-00003",{"doi":1513},"10.1097\u002F00000658-200010000-00003",{"id":26,"text":1515,"url":26,"identifiers":1516},"Hughes, 2008, Inter-kingdom signalling: communication between bacteria and their hosts, Nat Rev Microbiol, 6, 111, 10.1038\u002Fnrmicro1836",{"doi":1517},"10.1038\u002Fnrmicro1836",{"id":26,"text":1519,"url":26,"identifiers":1520},"Cogan, 2007, Norepinephrine increases the pathogenic potential of Campylobacter jejuni, Gut, 56, 1060, 10.1136\u002Fgut.2006.114926",{"doi":1521},"10.1136\u002Fgut.2006.114926",{"id":26,"text":1523,"url":26,"identifiers":1524},"Paulose, 2016, Human gut bacteria are sensitive to melatonin and express endogenous circadian rhythmicity, PLoS One, 11, e0146643, 10.1371\u002Fjournal.pone.0146643",{"doi":1525},"10.1371\u002Fjournal.pone.0146643",{"id":26,"text":1527,"url":26,"identifiers":1528},"Bubenik, 1997, Pinealectomy reduces melatonin levels in the serum but not in the gastrointestinal tract of rats, Biol Signals, 6, 40, 10.1159\u002F000109107",{"doi":1529},"10.1159\u002F000109107",{"id":26,"text":1531,"url":26,"identifiers":1532},"Bubenik, 1996, Melatonin concentrations in serum and tissues of porcine gastrointestinal tract and their relationship to the intake and passage of food, J Pineal Res, 21, 251, 10.1111\u002Fj.1600-079X.1996.tb00294.x",{"doi":1533},"10.1111\u002Fj.1600-079X.1996.tb00294.x",{"id":26,"text":1535,"url":26,"identifiers":1536},"Thaiss, 2014, Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis, Cell, 159, 514, 10.1016\u002Fj.cell.2014.09.048",{"doi":1537},"10.1016\u002Fj.cell.2014.09.048",{"id":26,"text":1539,"url":26,"identifiers":1540},"Simren, 2013, Rome Foundation Committee. Intestinal microbiota in functional bowel disorders: a Rome foundation report, Gut, 62, 159, 10.1136\u002Fgutjnl-2012-302167",{"doi":1541},"10.1136\u002Fgutjnl-2012-302167",{"id":26,"text":1543,"url":26,"identifiers":1544},"Labus, 2017, Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome, Microbiome, 5, 49, 10.1186\u002Fs40168-017-0260-z",{"doi":1545},"10.1186\u002Fs40168-017-0260-z",{"id":26,"text":1547,"url":26,"identifiers":1548},"Jeffery, 2012, An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota, Gut, 61, 997, 10.1136\u002Fgutjnl-2011-301501",{"doi":1549},"10.1136\u002Fgutjnl-2011-301501",{"id":26,"text":1551,"url":26,"identifiers":1552},"Tap, 2017, Identification of an intestinal microbiota signature associated with severity of irritable bowel syndrome, Gastroenterology, 152, 111, 10.1053\u002Fj.gastro.2016.09.049",{"doi":1553},"10.1053\u002Fj.gastro.2016.09.049",{"id":26,"text":1555,"url":26,"identifiers":1556},"Kerckhoffs, 2011, Molecular analysis of faecal and duodenal samples reveals significantly higher prevalence and numbers of Pseudomonas aeruginosa in irritable bowel syndrome, J Med Microbiol, 60, 236, 10.1099\u002Fjmm.0.022848-0",{"doi":1557},"10.1099\u002Fjmm.0.022848-0",{"id":26,"text":1559,"url":26,"identifiers":1560},"Pimentel, 2013, The first large scale deep sequencing of the duodenal microbiome in irritable bowel syndrome reveals striking differences compared to healthy controls, Gastroenterology, 144, S59, 10.1016\u002FS0016-5085(13)60213-9",{"doi":1561},"10.1016\u002FS0016-5085(13)60213-9",{"id":26,"text":1563,"url":26,"identifiers":1564},"Bailey, 2011, Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation, Brain Behav Immun, 25, 397, 10.1016\u002Fj.bbi.2010.10.023",{"doi":1565},"10.1016\u002Fj.bbi.2010.10.023",{"id":26,"text":1567,"url":26,"identifiers":1568},"Knowles, 2008, Investigating the role of perceived stress on bacterial flora activity and salivary cortisol secretion: a possible mechanism underlying susceptibility to illness, Biol Psychol, 77, 132, 10.1016\u002Fj.biopsycho.2007.09.010",{"doi":1569},"10.1016\u002Fj.biopsycho.2007.09.010",{"id":26,"text":1571,"url":26,"identifiers":1572},"Pedram, 2013, Food addiction: its prevalence and significant association with obesity in the general population, PLoS One, 8, e74832, 10.1371\u002Fjournal.pone.0074832",{"doi":1573},"10.1371\u002Fjournal.pone.0074832",{"id":26,"text":1575,"url":26,"identifiers":1576},"Lin, 2012, Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms, PLoS One, 7, e35240, 10.1371\u002Fjournal.pone.0035240",{"doi":1577},"10.1371\u002Fjournal.pone.0035240",{"id":26,"text":1579,"url":26,"identifiers":1580},"Everard, 2011, Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice, Diabetes, 60, 2775, 10.2337\u002Fdb11-0227",{"doi":1581},"10.2337\u002Fdb11-0227",{"id":26,"text":1583,"url":26,"identifiers":1584},"Turnbaugh, 2006, An obesity-associated gut microbiome with increased capacity for energy harvest, Nature, 444, 1027, 10.1038\u002Fnature05414",{"doi":1585},"10.1038\u002Fnature05414",{"id":26,"text":1587,"url":26,"identifiers":1588},"Fernandez-Real, 2015, Gut microbiota interacts with brain microstructure and function, J Clin Endocrinol Metab, 100, 4505, 10.1210\u002Fjc.2015-3076",{"doi":1589},"10.1210\u002Fjc.2015-3076",{"id":26,"text":1591,"url":26,"identifiers":1592},"Janik, 2016, Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate, Neuroimage, 125, 988, 10.1016\u002Fj.neuroimage.2015.11.018",{"doi":1593},"10.1016\u002Fj.neuroimage.2015.11.018",{"id":26,"text":1595,"url":26,"identifiers":1596},"Zhang, 2009, Human gut microbiota in obesity and after gastric bypass, Proc Natl Acad Sci U S A, 106, 2365, 10.1073\u002Fpnas.0812600106",{"doi":1597},"10.1073\u002Fpnas.0812600106",{"id":26,"text":1599,"url":26,"identifiers":1600},"Li, 2011, Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk, Gut, 60, 1214, 10.1136\u002Fgut.2010.234708",{"doi":1601},"10.1136\u002Fgut.2010.234708",{"id":26,"text":1603,"url":26,"identifiers":1604},"Damms-Machado, 2015, Effects of surgical and dietary weight loss therapy for obesity on gut microbiota composition and nutrient absorption, Biomed Res Int, 2015, 806248, 10.1155\u002F2015\u002F806248",{"doi":1605},"10.1155\u002F2015\u002F806248",{"id":26,"text":1607,"url":26,"identifiers":1608},"Furet, 2010, Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers, Diabetes, 59, 3049, 10.2337\u002Fdb10-0253",{"doi":1609},"10.2337\u002Fdb10-0253",{"id":26,"text":1611,"url":26,"identifiers":1612},"Graessler, 2013, Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters, Pharmacogenomics J, 13, 514, 10.1038\u002Ftpj.2012.43",{"doi":1613},"10.1038\u002Ftpj.2012.43",{"id":26,"text":1615,"url":26,"identifiers":1616},"Liou, 2013, Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity, Sci Transl Med, 5, 178ra41, 10.1126\u002Fscitranslmed.3005687",{"doi":1617},"10.1126\u002Fscitranslmed.3005687",{"id":26,"text":1619,"url":26,"identifiers":1620},"Tremaroli, 2015, Roux-en-Y gastric bypass and vertical banded gastroplasty induce long-term changes on the human gut microbiome contributing to fat mass regulation, Cell Metab, 22, 228, 10.1016\u002Fj.cmet.2015.07.009",{"doi":1621},"10.1016\u002Fj.cmet.2015.07.009",{"id":26,"text":1623,"url":26,"identifiers":1624},"Kelly, 2016, Brain-gut-microbiota axis: challenges for translation in psychiatry, Ann Epidemiol, 26, 366, 10.1016\u002Fj.annepidem.2016.02.008",{"doi":1625},"10.1016\u002Fj.annepidem.2016.02.008",{"id":26,"text":1627,"url":26,"identifiers":1628},"Mertsalmi, 2017, More than constipation - bowel symptoms in Parkinson's disease and their connection to gut microbiota, Eur J Neurol, 24, 1375, 10.1111\u002Fene.13398",{"doi":1629},"10.1111\u002Fene.13398",{"id":26,"text":1631,"url":26,"identifiers":1632},"Fasano, 2015, Gastrointestinal dysfunction in Parkinson's disease, Lancet Neurol, 14, 625, 10.1016\u002FS1474-4422(15)00007-1",{"doi":1633},"10.1016\u002FS1474-4422(15)00007-1",{"id":26,"text":1635,"url":26,"identifiers":1636},"Mayer, 2014, Altered brain-gut axis in autism: comorbidity or causative mechanisms?, Bioessays, 36, 933, 10.1002\u002Fbies.201400075",{"doi":1637},"10.1002\u002Fbies.201400075",{"id":26,"text":1639,"url":26,"identifiers":1640},"Kang, 2017, Microbiota transfer therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study, Microbiome, 5, 10, 10.1186\u002Fs40168-016-0225-7",{"doi":1641},"10.1186\u002Fs40168-016-0225-7",{"id":26,"text":1643,"url":26,"identifiers":1644},"Mayer, 2015, Towards a systems view of IBS, Nat Rev Gastroenterol Hepatol, 12, 592, 10.1038\u002Fnrgastro.2015.121",{"doi":1645},"10.1038\u002Fnrgastro.2015.121",{"id":26,"text":1647,"url":26,"identifiers":1648},"Bohorquez, 2015, The gut connectome: making sense of what you eat, J Clin Invest, 125, 888, 10.1172\u002FJCI81121",{"doi":1649},"10.1172\u002FJCI81121",{"id":26,"text":1651,"url":26,"identifiers":1652},"Sporns, 2013, The human connectome: origins and challenges, Neuroimage, 80, 53, 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Llorente",{"url":26,"publisher":1718,"properties":1740},{"id":659,"createTime":660,"updateTime":661,"relativeEntities":1719,"slug":663,"properties":1720,"entityType":24,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"subjectFields":1723,"manageAffiliations":1724,"indexDatabases":1725,"url":26,"thumbnailPath":26,"statistic":26,"gsStatistic":26,"type":26,"analyzePriority":26},[],{"issn":1721,"title":1722},{"VOID":666},{"EN":668},[],[],[1726,1733],{"id":699,"indexDatabase":1727,"url":712,"indexYears":713,"academicFieldIds":1732,"indexDatabaseRanking":717},{"id":701,"createTime":702,"updateTime":703,"relativeEntities":1728,"label":1729,"description":1730,"key":709,"publicationTags":1731,"standard":26},[],{"EN":706,"VI":706},{"EN":706,"VI":708},[711],[715,716],{"id":719,"indexDatabase":1734,"url":734,"indexYears":26,"academicFieldIds":1739,"indexDatabaseRanking":26},{"id":721,"createTime":722,"updateTime":723,"relativeEntities":1735,"label":1736,"description":1737,"key":730,"publicationTags":1738,"standard":26},[],{"EN":726,"VI":726},{"VI":728,"EN":729},[732,733],[736],{"volume":1741,"pages":1743,"issue":1745},{"VOID":1742},"1",{"VOID":1744},"275-284",{"VOID":1746},"3",{"total":243,"publishYear":26,"statisticByYear":1748},{"2015":114,"2016":53,"2017":239,"2018":516,"2019":234,"2020":298,"2021":173,"2022":336,"2023":356,"2024":116},"2015-05-01",2015,[1752,1756,1760,1764,1768,1772,1776,1780,1784,1786,1790,1794,1798,1802,1806,1810,1814,1818,1822,1826,1830,1833,1837,1841,1845,1849,1853,1857,1861,1865,1869,1873,1877,1881,1885,1889,1893,1897,1901,1905,1909,1913,1917,1921,1925,1929,1933,1937,1941,1945,1949,1953,1957,1961,1965,1969,1973,1977,1981,1984,1988,1992,1996,2000,2004,2008,2012,2016,2020,2024,2028,2032,2036,2039,2043,2047,2051,2055,2059,2063,2067,2071,2075,2079,2083,2087,2091,2095,2099,2103,2107,2111,2115,2119,2123,2126,2130,2134,2137,2141,2145,2149,2153,2157,2161,2163,2167,2171,2175,2179,2183,2187,2191,2195,2199,2203,2207],{"id":26,"text":1753,"url":26,"identifiers":1754},"Qin, 2010, A human gut microbial gene catalogue established by metagenomic sequencing, Nature, 464, 59, 10.1038\u002Fnature08821",{"doi":1755},"10.1038\u002Fnature08821",{"id":26,"text":1757,"url":26,"identifiers":1758},"Sonnenburg, 2005, Glycan foraging in vivo by an intestine-adapted bacterial symbiont, Science, 307, 1955, 10.1126\u002Fscience.1109051",{"doi":1759},"10.1126\u002Fscience.1109051",{"id":26,"text":1761,"url":26,"identifiers":1762},"Yatsunenko, 2012, Human gut microbiome viewed across age and geography, Nature, 486, 222, 10.1038\u002Fnature11053",{"doi":1763},"10.1038\u002Fnature11053",{"id":26,"text":1765,"url":26,"identifiers":1766},"Olszak, 2012, Microbial exposure during early life has persistent effects on natural killer T cell function, Science, 336, 489, 10.1126\u002Fscience.1219328",{"doi":1767},"10.1126\u002Fscience.1219328",{"id":26,"text":1769,"url":26,"identifiers":1770},"Uematsu, 2008, Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5, Nat Immunol, 9, 769, 10.1038\u002Fni.1622",{"doi":1771},"10.1038\u002Fni.1622",{"id":26,"text":1773,"url":26,"identifiers":1774},"Ley, 2006, Microbial ecology: human gut microbes associated with obesity, Nature, 444, 1022, 10.1038\u002F4441022a",{"doi":1775},"10.1038\u002F4441022a",{"id":26,"text":1777,"url":26,"identifiers":1778},"Kau, 2011, Human nutrition, the gut microbiome and the immune system, Nature, 474, 327, 10.1038\u002Fnature10213",{"doi":1779},"10.1038\u002Fnature10213",{"id":26,"text":1781,"url":26,"identifiers":1782},"Frank, 2007, Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases, Proc Natl Acad Sci USA, 104, 13780, 10.1073\u002Fpnas.0706625104",{"doi":1783},"10.1073\u002Fpnas.0706625104",{"id":26,"text":988,"url":26,"identifiers":1785},{"doi":990},{"id":26,"text":1787,"url":26,"identifiers":1788},"Yoshimoto, 2013, Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome, Nature, 499, 97, 10.1038\u002Fnature12347",{"doi":1789},"10.1038\u002Fnature12347",{"id":26,"text":1791,"url":26,"identifiers":1792},"Schnabl, 2014, Transplanting a fibrogenic microbiota, Hepatology, 59, 1660, 10.1002\u002Fhep.26785",{"doi":1793},"10.1002\u002Fhep.26785",{"id":26,"text":1795,"url":26,"identifiers":1796},"Hartmann, 2013, Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice, Hepatology, 58, 108, 10.1002\u002Fhep.26321",{"doi":1797},"10.1002\u002Fhep.26321",{"id":26,"text":1799,"url":26,"identifiers":1800},"Grivennikov, 2012, Adenoma-linked barrier defects and microbial products drive IL-23\u002FIL-17-mediated tumour growth, Nature, 491, 254, 10.1038\u002Fnature11465",{"doi":1801},"10.1038\u002Fnature11465",{"id":26,"text":1803,"url":26,"identifiers":1804},"Yan, 2011, Enteric dysbiosis associated with a mouse model of alcoholic liver disease, Hepatology, 53, 96, 10.1002\u002Fhep.24018",{"doi":1805},"10.1002\u002Fhep.24018",{"id":26,"text":1807,"url":26,"identifiers":1808},"Zhu, 2013, Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH, Hepatology, 57, 601, 10.1002\u002Fhep.26093",{"doi":1809},"10.1002\u002Fhep.26093",{"id":26,"text":1811,"url":26,"identifiers":1812},"Chen, 2015, Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice, Hepatology, 61, 883, 10.1002\u002Fhep.27489",{"doi":1813},"10.1002\u002Fhep.27489",{"id":26,"text":1815,"url":26,"identifiers":1816},"Turnbaugh, 2009, A core gut microbiome in obese and lean twins, Nature, 457, 480, 10.1038\u002Fnature07540",{"doi":1817},"10.1038\u002Fnature07540",{"id":26,"text":1819,"url":26,"identifiers":1820},"Jumpertz, 2011, Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans, Am J Clin Nutr, 94, 58, 10.3945\u002Fajcn.110.010132",{"doi":1821},"10.3945\u002Fajcn.110.010132",{"id":26,"text":1823,"url":26,"identifiers":1824},"Backhed, 2004, The gut microbiota as an environmental factor that regulates fat storage, Proc Natl Acad Sci USA, 101, 15718, 10.1073\u002Fpnas.0407076101",{"doi":1825},"10.1073\u002Fpnas.0407076101",{"id":26,"text":1827,"url":26,"identifiers":1828},"Leclercq, 2014, Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity, Proc Natl Acad Sci USA, 111, E4485, 10.1073\u002Fpnas.1415174111",{"doi":1829},"10.1073\u002Fpnas.1415174111",{"id":26,"text":1831,"url":26,"identifiers":1832},"Bode, 1984, Jejunal microflora in patients with chronic alcohol abuse, Hepatogastroenterology, 31, 30",{},{"id":26,"text":1834,"url":26,"identifiers":1835},"Mutlu, 2012, Colonic microbiome is altered in alcoholism, Am J Physiol Gastrointest Liver Physiol, 302, G966, 10.1152\u002Fajpgi.00380.2011",{"doi":1836},"10.1152\u002Fajpgi.00380.2011",{"id":26,"text":1838,"url":26,"identifiers":1839},"Mutlu, 2009, Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats, Alcohol Clin Exp Res, 33, 1836, 10.1111\u002Fj.1530-0277.2009.01022.x",{"doi":1840},"10.1111\u002Fj.1530-0277.2009.01022.x",{"id":26,"text":1842,"url":26,"identifiers":1843},"Bull-Otterson, 2013, Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosus GG treatment, PloS One, 8, e53028, 10.1371\u002Fjournal.pone.0053028",{"doi":1844},"10.1371\u002Fjournal.pone.0053028",{"id":26,"text":1846,"url":26,"identifiers":1847},"Chen, 2015, Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice, Gastroenterology, 148, 203, 10.1053\u002Fj.gastro.2014.09.014",{"doi":1848},"10.1053\u002Fj.gastro.2014.09.014",{"id":26,"text":1850,"url":26,"identifiers":1851},"Wang, 2011, Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury, Am J Pathol, 179, 2866, 10.1016\u002Fj.ajpath.2011.08.039",{"doi":1852},"10.1016\u002Fj.ajpath.2011.08.039",{"id":26,"text":1854,"url":26,"identifiers":1855},"Brandl, 2008, Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits, Nature, 455, 804, 10.1038\u002Fnature07250",{"doi":1856},"10.1038\u002Fnature07250",{"id":26,"text":1858,"url":26,"identifiers":1859},"Cho, 2012, Antibiotics in early life alter the murine colonic microbiome and adiposity, Nature, 488, 621, 10.1038\u002Fnature11400",{"doi":1860},"10.1038\u002Fnature11400",{"id":26,"text":1862,"url":26,"identifiers":1863},"Hildebrand, 2008, Early-life exposures associated with antibiotic use and risk of subsequent Crohn’s disease, Scand J Gastroenterol, 43, 961, 10.1080\u002F00365520801971736",{"doi":1864},"10.1080\u002F00365520801971736",{"id":26,"text":1866,"url":26,"identifiers":1867},"Card, 2004, Antibiotic use and the development of Crohn’s disease, Gut, 53, 246, 10.1136\u002Fgut.2003.025239",{"doi":1868},"10.1136\u002Fgut.2003.025239",{"id":26,"text":1870,"url":26,"identifiers":1871},"Gilat, 1987, Childhood factors in ulcerative colitis and Crohn’s disease: an international cooperative study, Scand J Gastroenterol, 22, 1009, 10.3109\u002F00365528708991950",{"doi":1872},"10.3109\u002F00365528708991950",{"id":26,"text":1874,"url":26,"identifiers":1875},"Dominguez-Bello, 2010, Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns, Proc Natl Acad Sci USA, 107, 11971, 10.1073\u002Fpnas.1002601107",{"doi":1876},"10.1073\u002Fpnas.1002601107",{"id":26,"text":1878,"url":26,"identifiers":1879},"Charlson, 2010, Disordered microbial communities in the upper respiratory tract of cigarette smokers, PloS One, 5, e15216, 10.1371\u002Fjournal.pone.0015216",{"doi":1880},"10.1371\u002Fjournal.pone.0015216",{"id":26,"text":1882,"url":26,"identifiers":1883},"Benjamin, 2012, Smokers with active Crohn’s disease have a clinically relevant dysbiosis of the gastrointestinal microbiota, Inflamm Bowel Dis, 18, 1092, 10.1002\u002Fibd.21864",{"doi":1884},"10.1002\u002Fibd.21864",{"id":26,"text":1886,"url":26,"identifiers":1887},"Biedermann, 2013, Smoking cessation induces profound changes in the composition of the intestinal microbiota in humans, PloS One, 8, e59260, 10.1371\u002Fjournal.pone.0059260",{"doi":1888},"10.1371\u002Fjournal.pone.0059260",{"id":26,"text":1890,"url":26,"identifiers":1891},"Walk, 2010, Alteration of the murine gut microbiota during infection with the parasitic helminth Heligmosomoides polygyrus, Inflamm Bowel Dis, 16, 1841, 10.1002\u002Fibd.21299",{"doi":1892},"10.1002\u002Fibd.21299",{"id":26,"text":1894,"url":26,"identifiers":1895},"Lee, 2011, Comparison of the gut microbiotas of healthy adult twins living in South Korea and the United States, Appl Environ Microbiol, 77, 7433, 10.1128\u002FAEM.05490-11",{"doi":1896},"10.1128\u002FAEM.05490-11",{"id":26,"text":1898,"url":26,"identifiers":1899},"Dicksved, 2008, Molecular analysis of the gut microbiota of identical twins with Crohn’s disease, ISME J, 2, 716, 10.1038\u002Fismej.2008.37",{"doi":1900},"10.1038\u002Fismej.2008.37",{"id":26,"text":1902,"url":26,"identifiers":1903},"Benson, 2010, Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors, Proc Natl Acad Sci USA, 107, 18933, 10.1073\u002Fpnas.1007028107",{"doi":1904},"10.1073\u002Fpnas.1007028107",{"id":26,"text":1906,"url":26,"identifiers":1907},"Goodrich, 2014, Human genetics shape the gut microbiome, Cell, 159, 789, 10.1016\u002Fj.cell.2014.09.053",{"doi":1908},"10.1016\u002Fj.cell.2014.09.053",{"id":26,"text":1910,"url":26,"identifiers":1911},"Knights, 2014, Complex host genetics influence the microbiome in inflammatory bowel disease, Genome Med, 6, 107, 10.1186\u002Fs13073-014-0107-1",{"doi":1912},"10.1186\u002Fs13073-014-0107-1",{"id":26,"text":1914,"url":26,"identifiers":1915},"Bruns, 2012, NOD2 gene variants are a risk factor for culture-positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis, Liver Int, 32, 223, 10.1111\u002Fj.1478-3231.2011.02561.x",{"doi":1916},"10.1111\u002Fj.1478-3231.2011.02561.x",{"id":26,"text":1918,"url":26,"identifiers":1919},"Appenrodt, 2010, Nucleotide-binding oligomerization domain containing 2 (NOD2) variants are genetic risk factors for death and spontaneous bacterial peritonitis in liver cirrhosis, Hepatology, 51, 1327, 10.1002\u002Fhep.23440",{"doi":1920},"10.1002\u002Fhep.23440",{"id":26,"text":1922,"url":26,"identifiers":1923},"Saner, 2014, A non-interventional study of the genetic polymorphisms of NOD2 associated with increased mortality in non-alcoholic liver transplant patients, BMC Gastroenterol, 14, 4, 10.1186\u002F1471-230X-14-4",{"doi":1924},"10.1186\u002F1471-230X-14-4",{"id":26,"text":1926,"url":26,"identifiers":1927},"Elinav, 2011, NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis, Cell, 145, 745, 10.1016\u002Fj.cell.2011.04.022",{"doi":1928},"10.1016\u002Fj.cell.2011.04.022",{"id":26,"text":1930,"url":26,"identifiers":1931},"Henao-Mejia, 2012, Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity, Nature, 482, 179, 10.1038\u002Fnature10809",{"doi":1932},"10.1038\u002Fnature10809",{"id":26,"text":1934,"url":26,"identifiers":1935},"Hedin, 2014, Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn’s disease and their unaffected siblings, Gut, 63, 1578, 10.1136\u002Fgutjnl-2013-306226",{"doi":1936},"10.1136\u002Fgutjnl-2013-306226",{"id":26,"text":1938,"url":26,"identifiers":1939},"Hooper, 2012, Interactions between the microbiota and the immune system, Science, 336, 1268, 10.1126\u002Fscience.1223490",{"doi":1940},"10.1126\u002Fscience.1223490",{"id":26,"text":1942,"url":26,"identifiers":1943},"Swidsinski, 2007, Viscosity gradient within the mucus layer determines the mucosal barrier function and the spatial organization of the intestinal microbiota, Inflamm Bowel Dis, 13, 963, 10.1002\u002Fibd.20163",{"doi":1944},"10.1002\u002Fibd.20163",{"id":26,"text":1946,"url":26,"identifiers":1947},"Sommer, 2013, The gut microbiota—masters of host development and physiology, Nat Rev Microbiol, 11, 227, 10.1038\u002Fnrmicro2974",{"doi":1948},"10.1038\u002Fnrmicro2974",{"id":26,"text":1950,"url":26,"identifiers":1951},"Yang, 2001, Participation of mammalian defensins and cathelicidins in anti-microbial immunity: receptors and activities of human defensins and cathelicidin (LL-37), J Leukoc Biol, 69, 691, 10.1189\u002Fjlb.69.5.691",{"doi":1952},"10.1189\u002Fjlb.69.5.691",{"id":26,"text":1954,"url":26,"identifiers":1955},"Kubinak, 2015, MyD88 Signaling in T cells directs IgA-mediated control of the microbiota to promote health, Cell Host Microbe, 17, 153, 10.1016\u002Fj.chom.2014.12.009",{"doi":1956},"10.1016\u002Fj.chom.2014.12.009",{"id":26,"text":1958,"url":26,"identifiers":1959},"Macpherson, 2000, A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria, Science, 288, 2222, 10.1126\u002Fscience.288.5474.2222",{"doi":1960},"10.1126\u002Fscience.288.5474.2222",{"id":26,"text":1962,"url":26,"identifiers":1963},"Kawamoto, 2012, The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut, Science, 336, 485, 10.1126\u002Fscience.1217718",{"doi":1964},"10.1126\u002Fscience.1217718",{"id":26,"text":1966,"url":26,"identifiers":1967},"Petnicki-Ocwieja, 2009, Nod2 is required for the regulation of commensal microbiota in the intestine, Proc Natl Acad Sci USA, 106, 15813, 10.1073\u002Fpnas.0907722106",{"doi":1968},"10.1073\u002Fpnas.0907722106",{"id":26,"text":1970,"url":26,"identifiers":1971},"Salzman, 2010, Enteric defensins are essential regulators of intestinal microbial ecology, Nat Immunol, 11, 76, 10.1038\u002Fni.1825",{"doi":1972},"10.1038\u002Fni.1825",{"id":26,"text":1974,"url":26,"identifiers":1975},"Vaishnava, 2011, The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine, Science, 334, 255, 10.1126\u002Fscience.1209791",{"doi":1976},"10.1126\u002Fscience.1209791",{"id":26,"text":1978,"url":26,"identifiers":1979},"Teltschik, 2012, Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense, Hepatology, 55, 1154, 10.1002\u002Fhep.24789",{"doi":1980},"10.1002\u002Fhep.24789",{"id":26,"text":1982,"url":26,"identifiers":1983},"Johansson, 2011, The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions, Proc Natl Acad Sci USA, 108, 4659, 10.1073\u002Fpnas.1006451107",{"doi":1385},{"id":26,"text":1985,"url":26,"identifiers":1986},"Juge, 2012, Microbial adhesins to gastrointestinal mucus, Trends Microbiol, 20, 30, 10.1016\u002Fj.tim.2011.10.001",{"doi":1987},"10.1016\u002Fj.tim.2011.10.001",{"id":26,"text":1989,"url":26,"identifiers":1990},"Derrien, 2010, Mucin-bacterial interactions in the human oral cavity and digestive tract, Gut Microbes, 1, 254, 10.4161\u002Fgmic.1.4.12778",{"doi":1991},"10.4161\u002Fgmic.1.4.12778",{"id":26,"text":1993,"url":26,"identifiers":1994},"Zarepour, 2013, The mucin Muc2 limits pathogen burdens and epithelial barrier dysfunction during Salmonella enterica serovar Typhimurium colitis, Infect Immun, 81, 3672, 10.1128\u002FIAI.00854-13",{"doi":1995},"10.1128\u002FIAI.00854-13",{"id":26,"text":1997,"url":26,"identifiers":1998},"Sovran, 2015, IL-22-STAT3 pathway plays a key role in the maintenance of ileal homeostasis in mice lacking secreted mucus barrier, Inflamm Bowel Dis, 21, 531, 10.1097\u002FMIB.0000000000000319",{"doi":1999},"10.1097\u002FMIB.0000000000000319",{"id":26,"text":2001,"url":26,"identifiers":2002},"Qin, 2014, Alterations of the human gut microbiome in liver cirrhosis, Nature, 513, 59, 10.1038\u002Fnature13568",{"doi":2003},"10.1038\u002Fnature13568",{"id":26,"text":2005,"url":26,"identifiers":2006},"Scobie, 1964, Reduced gastric acid output in cirrhosis: quantitation and relationships, Gut, 5, 422, 10.1136\u002Fgut.5.5.422",{"doi":2007},"10.1136\u002Fgut.5.5.422",{"id":26,"text":2009,"url":26,"identifiers":2010},"Lu, 2011, Intestinal microbiota was assessed in cirrhotic patients with hepatitis B virus infection. Intestinal microbiota of HBV cirrhotic patients, Microb Ecol, 61, 693, 10.1007\u002Fs00248-010-9801-8",{"doi":2011},"10.1007\u002Fs00248-010-9801-8",{"id":26,"text":2013,"url":26,"identifiers":2014},"Schnabl, 2014, Interactions between the intestinal microbiome and liver diseases, Gastroenterology, 146, 1513, 10.1053\u002Fj.gastro.2014.01.020",{"doi":2015},"10.1053\u002Fj.gastro.2014.01.020",{"id":26,"text":2017,"url":26,"identifiers":2018},"Hartmann, 2015, Alcoholic liver disease: the gut microbiome and liver crosstalk, Alcohol Clin Exp Res, 39, 763, 10.1111\u002Facer.12704",{"doi":2019},"10.1111\u002Facer.12704",{"id":26,"text":2021,"url":26,"identifiers":2022},"De Minicis, 2014, Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice, Hepatology, 59, 1738, 10.1002\u002Fhep.26695",{"doi":2023},"10.1002\u002Fhep.26695",{"id":26,"text":2025,"url":26,"identifiers":2026},"Cani, 2007, Metabolic endotoxemia initiates obesity and insulin resistance, Diabetes, 56, 1761, 10.2337\u002Fdb06-1491",{"doi":2027},"10.2337\u002Fdb06-1491",{"id":26,"text":2029,"url":26,"identifiers":2030},"Teixeira, 2012, Intestinal permeability parameters in obese patients are correlated with metabolic syndrome risk factors, Clin Nutr, 31, 735, 10.1016\u002Fj.clnu.2012.02.009",{"doi":2031},"10.1016\u002Fj.clnu.2012.02.009",{"id":26,"text":2033,"url":26,"identifiers":2034},"Miele, 2009, Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease, Hepatology, 49, 1877, 10.1002\u002Fhep.22848",{"doi":2035},"10.1002\u002Fhep.22848",{"id":26,"text":2037,"url":26,"identifiers":2038},"Keshavarzian, 1994, The differing effects of acute and chronic alcohol on gastric and intestinal permeability, Am J Gastroenterol, 89, 2205",{},{"id":26,"text":2040,"url":26,"identifiers":2041},"Pendyala, 2011, Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis, Am J Clin Nutr, 93, 234, 10.3945\u002Fajcn.110.002683",{"doi":2042},"10.3945\u002Fajcn.110.002683",{"id":26,"text":2044,"url":26,"identifiers":2045},"Ding, 2010, High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse, PLoS One, 5, e12191, 10.1371\u002Fjournal.pone.0012191",{"doi":2046},"10.1371\u002Fjournal.pone.0012191",{"id":26,"text":2048,"url":26,"identifiers":2049},"Amar, 2008, Energy intake is associated with endotoxemia in apparently healthy men, Am J Clin Nutr, 87, 1219, 10.1093\u002Fajcn\u002F87.5.1219",{"doi":2050},"10.1093\u002Fajcn\u002F87.5.1219",{"id":26,"text":2052,"url":26,"identifiers":2053},"Erridge, 2007, A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation, Am J Clin Nutr, 86, 1286, 10.1093\u002Fajcn\u002F86.5.1286",{"doi":2054},"10.1093\u002Fajcn\u002F86.5.1286",{"id":26,"text":2056,"url":26,"identifiers":2057},"Alisi, 2010, Endotoxin and plasminogen activator inhibitor-1 serum levels associated with nonalcoholic steatohepatitis in children, J Pediatr Gastroenterol Nutr, 50, 645, 10.1097\u002FMPG.0b013e3181c7bdf1",{"doi":2058},"10.1097\u002FMPG.0b013e3181c7bdf1",{"id":26,"text":2060,"url":26,"identifiers":2061},"Farhadi, 2008, Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis, Liver Int, 28, 1026, 10.1111\u002Fj.1478-3231.2008.01723.x",{"doi":2062},"10.1111\u002Fj.1478-3231.2008.01723.x",{"id":26,"text":2064,"url":26,"identifiers":2065},"Garcia-Tsao, 1995, Bacterial translocation to mesenteric lymph nodes is increased in cirrhotic rats with ascites, Gastroenterology, 108, 1835, 10.1016\u002F0016-5085(95)90147-7",{"doi":2066},"10.1016\u002F0016-5085(95)90147-7",{"id":26,"text":2068,"url":26,"identifiers":2069},"Saitoh, 1999, Increased prevalence of intestinal inflammation in patients with liver cirrhosis, World J Gastroenterol, 5, 391, 10.3748\u002Fwjg.v5.i5.391",{"doi":2070},"10.3748\u002Fwjg.v5.i5.391",{"id":26,"text":2072,"url":26,"identifiers":2073},"Du Plessis, 2013, Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function, J Hepatol, 58, 1125, 10.1016\u002Fj.jhep.2013.01.038",{"doi":2074},"10.1016\u002Fj.jhep.2013.01.038",{"id":26,"text":2076,"url":26,"identifiers":2077},"Wiest, 2014, Reply to: “Bacterial translocation in liver cirrhosis: site and role in fibrogenesis”, J Hepatol, 61, 710, 10.1016\u002Fj.jhep.2014.06.004",{"doi":2078},"10.1016\u002Fj.jhep.2014.06.004",{"id":26,"text":2080,"url":26,"identifiers":2081},"Wiest, 2014, Pathological bacterial translocation in liver cirrhosis, J Hepatol, 60, 197, 10.1016\u002Fj.jhep.2013.07.044",{"doi":2082},"10.1016\u002Fj.jhep.2013.07.044",{"id":26,"text":2084,"url":26,"identifiers":2085},"Uesugi, 2001, Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice, Hepatology, 34, 101, 10.1053\u002Fjhep.2001.25350",{"doi":2086},"10.1053\u002Fjhep.2001.25350",{"id":26,"text":2088,"url":26,"identifiers":2089},"Hritz, 2008, The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88, Hepatology, 48, 1224, 10.1002\u002Fhep.22470",{"doi":2090},"10.1002\u002Fhep.22470",{"id":26,"text":2092,"url":26,"identifiers":2093},"Seki, 2007, TLR4 enhances TGF-beta signaling and hepatic fibrosis, Nat Med, 13, 1324, 10.1038\u002Fnm1663",{"doi":2094},"10.1038\u002Fnm1663",{"id":26,"text":2096,"url":26,"identifiers":2097},"Hartmann, 2012, Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice, Gastroenterology, 143, 1330, 10.1053\u002Fj.gastro.2012.07.099",{"doi":2098},"10.1053\u002Fj.gastro.2012.07.099",{"id":26,"text":2100,"url":26,"identifiers":2101},"Saberi, 2009, Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice, Cell Metab, 10, 419, 10.1016\u002Fj.cmet.2009.09.006",{"doi":2102},"10.1016\u002Fj.cmet.2009.09.006",{"id":26,"text":2104,"url":26,"identifiers":2105},"Miura, 2010, Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1 beta in mice, Gastroenterology, 139, 323, 10.1053\u002Fj.gastro.2010.03.052",{"doi":2106},"10.1053\u002Fj.gastro.2010.03.052",{"id":26,"text":2108,"url":26,"identifiers":2109},"Rivera, 2007, Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis, J Hepatol, 47, 571, 10.1016\u002Fj.jhep.2007.04.019",{"doi":2110},"10.1016\u002Fj.jhep.2007.04.019",{"id":26,"text":2112,"url":26,"identifiers":2113},"Cani, 2008, Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice, Diabetes, 57, 1470, 10.2337\u002Fdb07-1403",{"doi":2114},"10.2337\u002Fdb07-1403",{"id":26,"text":2116,"url":26,"identifiers":2117},"Adachi, 1995, Antibiotics prevent liver injury in rats following long-term exposure to ethanol, Gastroenterology, 108, 218, 10.1016\u002F0016-5085(95)90027-6",{"doi":2118},"10.1016\u002F0016-5085(95)90027-6",{"id":26,"text":2120,"url":26,"identifiers":2121},"Douhara, 2015, Reduction of endotoxin attenuates liver fibrosis through suppression of hepatic stellate cell activation and remission of intestinal permeability in a rat non-alcoholic steatohepatitis model, Mol Med Rep, 11, 1693, 10.3892\u002Fmmr.2014.2995",{"doi":2122},"10.3892\u002Fmmr.2014.2995",{"id":26,"text":2124,"url":26,"identifiers":2125},"Bode, 1997, Effect of treatment with paromomycin on endotoxemia in patients with alcoholic liver disease—a double-blind, placebo-controlled trial, Alcohol Clin Exp Res, 21, 1367",{},{"id":26,"text":2127,"url":26,"identifiers":2128},"Bass, 2010, Rifaximin treatment in hepatic encephalopathy, N Engl J Med, 362, 1071, 10.1056\u002FNEJMoa0907893",{"doi":2129},"10.1056\u002FNEJMoa0907893",{"id":26,"text":2131,"url":26,"identifiers":2132},"Mazagova, 2015, Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice, FASEB J, 29, 1043, 10.1096\u002Ffj.14-259515",{"doi":2133},"10.1096\u002Ffj.14-259515",{"id":26,"text":2135,"url":26,"identifiers":2136},"Wikoff, 2009, Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites, Proc Natl Acad Sci USA, 106, 3698, 10.1073\u002Fpnas.0812874106",{"doi":1161},{"id":26,"text":2138,"url":26,"identifiers":2139},"Venkatesh, 2014, Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4, Immunity, 41, 296, 10.1016\u002Fj.immuni.2014.06.014",{"doi":2140},"10.1016\u002Fj.immuni.2014.06.014",{"id":26,"text":2142,"url":26,"identifiers":2143},"Abu-Shanab, 2010, The role of the gut microbiota in nonalcoholic fatty liver disease, Nat Rev Gastroenterol Hepatol, 7, 691, 10.1038\u002Fnrgastro.2010.172",{"doi":2144},"10.1038\u002Fnrgastro.2010.172",{"id":26,"text":2146,"url":26,"identifiers":2147},"Hildebrandt, 2009, High-fat diet determines the composition of the murine gut microbiome independently of obesity, Gastroenterology, 137, 1716, 10.1053\u002Fj.gastro.2009.08.042",{"doi":2148},"10.1053\u002Fj.gastro.2009.08.042",{"id":26,"text":2150,"url":26,"identifiers":2151},"Conterno, 2011, Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease?, Genes Nutr, 6, 241, 10.1007\u002Fs12263-011-0230-1",{"doi":2152},"10.1007\u002Fs12263-011-0230-1",{"id":26,"text":2154,"url":26,"identifiers":2155},"Backhed, 2007, Mechanisms underlying the resistance to diet-induced obesity in germ-free mice, Proc Natl Acad Sci USA, 104, 979, 10.1073\u002Fpnas.0605374104",{"doi":2156},"10.1073\u002Fpnas.0605374104",{"id":26,"text":2158,"url":26,"identifiers":2159},"Ridaura, 2013, Gut microbiota from twins discordant for obesity modulate metabolism in mice, Science, 341, 1241214, 10.1126\u002Fscience.1241214",{"doi":2160},"10.1126\u002Fscience.1241214",{"id":26,"text":1583,"url":26,"identifiers":2162},{"doi":1585},{"id":26,"text":2164,"url":26,"identifiers":2165},"Nair, 2001, Obesity and female gender increase breath ethanol concentration: potential implications for the pathogenesis of nonalcoholic steatohepatitis, Am J Gastroenterol, 96, 1200, 10.1111\u002Fj.1572-0241.2001.03702.x",{"doi":2166},"10.1111\u002Fj.1572-0241.2001.03702.x",{"id":26,"text":2168,"url":26,"identifiers":2169},"Cope, 2000, Increased gastrointestinal ethanol production in obese mice: implications for fatty liver disease pathogenesis, Gastroenterology, 119, 1340, 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to the study of mechanisms of clinical anti-cancer drug resistance, Proc Natl Acad Sci U S A, 108, 18708, 10.1073\u002Fpnas.1111840108",{"doi":2590},"10.1073\u002Fpnas.1111840108",{"id":26,"text":2592,"url":26,"identifiers":2593},"Sandberg, 2005, Assessment of tumor characteristic gene expression in cell lines using a tissue similarity index (TSI), Proc Natl Acad Sci U S A, 102, 2052, 10.1073\u002Fpnas.0408105102",{"doi":2594},"10.1073\u002Fpnas.0408105102",{"id":26,"text":2596,"url":26,"identifiers":2597},"Stein, 2004, Intractable cancers: the many faces of multidrug resistance and the many targets it presents for therapeutic attack, Curr Drug Targets, 5, 333, 10.2174\u002F1389450043345489",{"doi":2598},"10.2174\u002F1389450043345489",{"id":26,"text":2600,"url":26,"identifiers":2601},"Bianchini, 2014, The immune system and response to HER2-targeted treatment in breast cancer, Lancet Oncol, 15, e58, 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distinct populations, Proc Natl Acad Sci U S A, 109, 466, 10.1073\u002Fpnas.1118857109\nMunoz, 2012, The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers, EMBO J, 31, 3079, 10.1038\u002Femboj.2012.166\nPowell, 2012, The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor, Cell, 149, 146, 10.1016\u002Fj.cell.2012.02.042\nClevers, 2006, Wnt\u002Fbeta-catenin signaling in development and disease, Cell, 127, 469, 10.1016\u002Fj.cell.2006.10.018\nNusse, 2017, Wnt\u002Fbeta-catenin signaling, disease, and emerging therapeutic modalities, Cell, 169, 985, 10.1016\u002Fj.cell.2017.05.016\nDing, 2012, Inflammation and disruption of the mucosal architecture in claudin-7-deficient mice, Gastroenterology, 142, 305, 10.1053\u002Fj.gastro.2011.10.025\nXing, 2017, Animal models for studying epithelial barriers in neonatal necrotizing enterocolitis, inflammatory bowel disease and colorectal cancer, Tissue Barriers, 5, 10.1080\u002F21688370.2017.1356901\nHagen, 2018, Loss of tight junction protein claudin 18 promotes progressive neoplasia development in mouse stomach, Gastroenterology, 155, 1852, 10.1053\u002Fj.gastro.2018.08.041\nZhou, 2018, Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis, J Clin Invest, 128, 970, 10.1172\u002FJCI90429\nPearce, 2018, Marked differences in tight junction composition and macromolecular permeability among different intestinal cell types, BMC Biol, 16, 19, 10.1186\u002Fs12915-018-0481-z\nBry, 1994, Paneth cell differentiation in the developing intestine of normal and transgenic mice, Proc Natl Acad Sci U S A, 91, 10335, 10.1073\u002Fpnas.91.22.10335\nGerbe, 2012, The intestinal epithelium tuft cells: specification and function, Cell Mol Life Sci, 69, 2907, 10.1007\u002Fs00018-012-0984-7\nTetteh, 2015, Plasticity within stem cell hierarchies in mammalian epithelia, Trends Cell Biol, 25, 100, 10.1016\u002Fj.tcb.2014.09.003\nSnippert, 2009, Prominin-1\u002FCD133 marks stem cells and early progenitors in mouse small intestine, Gastroenterology, 136, 2187, 10.1053\u002Fj.gastro.2009.03.002\nAnholt, 2014, Olfactomedin proteins: central players in development and disease, Front Cell Dev Biol, 2, 6, 10.3389\u002Ffcell.2014.00006\nLi, 2018, Severe intestinal inflammation in the small intestine of mice induced by controllable deletion of claudin-7, Dig Dis Sci, 63, 1200, 10.1007\u002Fs10620-018-4973-z\nFevr, 2007, Wnt\u002Fbeta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells, Mol Cell Biol, 27, 7551, 10.1128\u002FMCB.01034-07\nde Lau, 2011, Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling, Nature, 476, 293, 10.1038\u002Fnature10337\nBlache, 2004, SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes, J Cell Biol, 166, 37, 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2016, Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes, Hepatology, 64, 73, 10.1002\u002Fhep.28431",{"doi":3115},"10.1002\u002Fhep.28431",{"id":26,"text":3117,"url":26,"identifiers":3118},"Cohen, 2011, Human fatty liver disease: old questions and new insights, Science, 332, 1519, 10.1126\u002Fscience.1204265",{"doi":3119},"10.1126\u002Fscience.1204265",{"id":26,"text":3121,"url":26,"identifiers":3122},"Buch, 2015, A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis, Nat Genet, 47, 1443, 10.1038\u002Fng.3417",{"doi":3123},"10.1038\u002Fng.3417",{"id":26,"text":3125,"url":26,"identifiers":3126},"Romeo, 2008, Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease, Nat Genet, 40, 1461, 10.1038\u002Fng.257",{"doi":3127},"10.1038\u002Fng.257",{"id":26,"text":3129,"url":26,"identifiers":3130},"Kozlitina, 2014, Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease, Nat Genet, 46, 352, 10.1038\u002Fng.2901",{"doi":3131},"10.1038\u002Fng.2901",{"id":26,"text":3133,"url":26,"identifiers":3134},"Speliotes, 2011, Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits, PLoS Genet, 7, 10.1371\u002Fjournal.pgen.1001324",{"doi":3135},"10.1371\u002Fjournal.pgen.1001324",{"id":26,"text":3137,"url":26,"identifiers":3138},"Mahdessian, 2014, TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content, Proc Natl Acad Sci U S A, 111, 8913, 10.1073\u002Fpnas.1323785111",{"doi":3139},"10.1073\u002Fpnas.1323785111",{"id":26,"text":3141,"url":26,"identifiers":3142},"Newberry, 2021, Liver-specific deletion of mouse Tm6sf2 promotes steatosis, fibrosis, and hepatocellular cancer, Hepatology, 74, 1203, 10.1002\u002Fhep.31771",{"doi":3143},"10.1002\u002Fhep.31771",{"id":26,"text":3145,"url":26,"identifiers":3146},"Smagris, 2016, Inactivation of Tm6sf2, a gene defective in fatty liver disease, impairs lipidation but not secretion of very low density lipoproteins, J Biol Chem, 291, 10659, 10.1074\u002Fjbc.M116.719955",{"doi":3147},"10.1074\u002Fjbc.M116.719955",{"id":26,"text":3149,"url":26,"identifiers":3150},"Olofsson, 2000, Intracellular assembly of VLDL: two major steps in separate cell compartments, Trends Cardiovasc Med, 10, 338, 10.1016\u002FS1050-1738(01)00071-8",{"doi":3151},"10.1016\u002FS1050-1738(01)00071-8",{"id":26,"text":3153,"url":26,"identifiers":3154},"Wetterau, 1992, Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia, Science, 258, 999, 10.1126\u002Fscience.1439810",{"doi":3155},"10.1126\u002Fscience.1439810",{"id":26,"text":3157,"url":26,"identifiers":3158},"Raabe, 1998, Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes, Proc Natl Acad Sci U S A, 95, 8686, 10.1073\u002Fpnas.95.15.8686",{"doi":3159},"10.1073\u002Fpnas.95.15.8686",{"id":26,"text":3161,"url":26,"identifiers":3162},"Raabe, 1999, Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice, J Clin Invest, 103, 1287, 10.1172\u002FJCI6576",{"doi":3163},"10.1172\u002FJCI6576",{"id":26,"text":3165,"url":26,"identifiers":3166},"Yamaguchi, 2003, The conversion of apoB100 low density lipoprotein\u002Fhigh density lipoprotein particles to apoB100 very low density lipoproteins in response to oleic acid occurs in the endoplasmic reticulum and not in the Golgi in McA RH7777 cells, J Biol Chem, 278, 42643, 10.1074\u002Fjbc.M306920200",{"doi":3167},"10.1074\u002Fjbc.M306920200",{"id":26,"text":3169,"url":26,"identifiers":3170},"Gusarova, 2003, Apolipoprotein B100 exit from the endoplasmic reticulum (ER) is COPII-dependent, and its lipidation to very low density lipoprotein occurs post-ER, J Biol Chem, 278, 48051, 10.1074\u002Fjbc.M306898200",{"doi":3171},"10.1074\u002Fjbc.M306898200",{"id":26,"text":3173,"url":26,"identifiers":3174},"Cartwright, 2001, Direct evidence for a two-step assembly of ApoB48-containing lipoproteins in the lumen of the smooth endoplasmic reticulum of rabbit enterocytes, J Biol Chem, 276, 48048, 10.1074\u002Fjbc.M104229200",{"doi":3175},"10.1074\u002Fjbc.M104229200",{"id":26,"text":3177,"url":26,"identifiers":3178},"Tang, 2010, Reconstitution of the cell cycle-regulated Golgi disassembly and reassembly in a cell-free system, Nat Protoc, 5, 758, 10.1038\u002Fnprot.2010.38",{"doi":3179},"10.1038\u002Fnprot.2010.38",{"id":26,"text":3181,"url":26,"identifiers":3182},"Millar, 2005, Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339, J Lipid Res, 46, 2023, 10.1194\u002Fjlr.D500019-JLR200",{"doi":3183},"10.1194\u002Fjlr.D500019-JLR200",{"id":26,"text":3185,"url":26,"identifiers":3186},"Xia, 2021, Hepatic deletion of Mboat7 (LPIAT1) causes activation of SREBP-1c and fatty liver, J Lipid Res, 62, 100031, 10.1194\u002Fjlr.RA120000856",{"doi":3187},"10.1194\u002Fjlr.RA120000856",{"id":26,"text":3189,"url":26,"identifiers":3190},"Schweizer, 1991, The isolated ER-Golgi intermediate compartment exhibits properties that are different from ER and cis-Golgi, J Cell Biol, 113, 45, 10.1083\u002Fjcb.113.1.45",{"doi":3191},"10.1083\u002Fjcb.113.1.45",{"id":26,"text":3193,"url":26,"identifiers":3194},"Newberry, 2021, Liver-specific deletion of Mttp versus Tm6sf2 reveals distinct defects in stepwise VLDL assembly, J Lipid Res, 62, 100080, 10.1016\u002Fj.jlr.2021.100080",{"doi":3195},"10.1016\u002Fj.jlr.2021.100080",{"id":26,"text":3197,"url":26,"identifiers":3198},"Hammond, 1994, Quality control in the secretory pathway: retention of a misfolded viral membrane glycoprotein involves cycling between the ER, intermediate compartment, and Golgi apparatus, J Cell Biol, 126, 41, 10.1083\u002Fjcb.126.1.41",{"doi":3199},"10.1083\u002Fjcb.126.1.41",{"id":26,"text":3201,"url":26,"identifiers":3202},"Siddiqi, 2015, In vitro analysis of the very-low density lipoprotein export from the trans-Golgi network, Curr Protoc Cell Biol, 67, 11211, 10.1002\u002F0471143030.cb1121s67",{"doi":3203},"10.1002\u002F0471143030.cb1121s67",{"id":26,"text":3205,"url":26,"identifiers":3206},"Li, 2020, Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease, PLoS Genet, 16, 10.1371\u002Fjournal.pgen.1008955",{"doi":3207},"10.1371\u002Fjournal.pgen.1008955",{"id":26,"text":3209,"url":26,"identifiers":3210},"Alexander, 1976, Subcellular localization of B apoprotein of plasma lipoproteins in rat liver, J Cell Biol, 69, 241, 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a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Proc Natl Acad Sci U S A, 79, 1185, 10.1073\u002Fpnas.79.4.1185",{"doi":3227},"10.1073\u002Fpnas.79.4.1185",{"id":26,"text":3229,"url":26,"identifiers":3230},"Claude, 1970, Growth and differentiation of cytoplasmic membranes in the course of lipoprotein granule synthesis in the hepatic cell. I. Elaboration of elements of the Golgi complex, J Cell Biol, 47, 745, 10.1083\u002Fjcb.47.3.745",{"doi":3231},"10.1083\u002Fjcb.47.3.745",{"id":26,"text":3233,"url":26,"identifiers":3234},"Vincent, 1998, Function of the KKXX motif in endoplasmic reticulum retrieval of a transmembrane protein depends on the length and structure of the cytoplasmic domain, J Biol Chem, 273, 950, 10.1074\u002Fjbc.273.2.950",{"doi":3235},"10.1074\u002Fjbc.273.2.950",{"id":26,"text":3237,"url":26,"identifiers":3238},"Mashek, 2006, Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglycerol in McArdle-RH7777 cells, J Biol Chem, 281, 945, 10.1074\u002Fjbc.M507646200",{"doi":3239},"10.1074\u002Fjbc.M507646200",{"id":26,"text":3241,"url":26,"identifiers":3242},"Oikawa, 1998, A novel acyl-CoA synthetase, ACS5, expressed in intestinal epithelial cells and proliferating preadipocytes, J Biochem, 124, 679, 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2019, A global scientific strategy to cure hepatitis B, Lancet Gastroenterol Hepatol, 4, 545, 10.1016\u002FS2468-1253(19)30119-0","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS2468125319301190",{"doi":4097},"10.1016\u002Fs2468-1253(19)30119-0",{"id":4099,"text":4100,"url":4101,"identifiers":4102},"a7ed92ee-07b1-43c3-8e13-40eca192093c","Fung, 2022, Getting to HBV cure: the promising paths forward, Hepatology, 76, 233, 10.1002\u002Fhep.32314","https:\u002F\u002Fjournals.lww.com\u002F10.1002\u002Fhep.32314",{"doi":4103},"10.1002\u002Fhep.32314",{"id":4105,"text":4106,"url":4107,"identifiers":4108},"73183365-e273-4a98-8369-5f0743b3e7d7","Martinez, 2021, Covalently closed circular DNA: the ultimate therapeutic target for curing HBV infections, J Hepatol, 75, 706, 10.1016\u002Fj.jhep.2021.05.013","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0168827821003482",{"doi":4109},"10.1016\u002Fj.jhep.2021.05.013",{"id":4111,"text":4112,"url":4113,"identifiers":4114},"673ccfee-9371-41ab-963e-1f1c1da90ac5","Schuch, 2019, Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load, Gut, 68, 905, 10.1136\u002Fgutjnl-2018-316641","https:\u002F\u002Fgut.bmj.com\u002Flookup\u002Fdoi\u002F10.1136\u002Fgutjnl-2018-316641",{"doi":4115},"10.1136\u002Fgutjnl-2018-316641",{"id":4117,"text":4118,"url":4119,"identifiers":4120},"ca6abacc-2c51-457b-a7fd-a7841ae199d9","Lebosse, 2017, Intrahepatic innate immune response pathways are downregulated in untreated chronic hepatitis B, J Hepatol, 66, 897, 10.1016\u002Fj.jhep.2016.12.024","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS0168827816307577",{"doi":4121},"10.1016\u002Fj.jhep.2016.12.024",{"id":4123,"text":4124,"url":4125,"identifiers":4126},"4c68646b-0035-4279-8000-0006b275d4fa","Soriano, 2018, Hepatitis B gene therapy coming to age, AIDS Rev, 20, 125","https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs10440-022-00541-7",{"doi":4127},"10.1007\u002Fs10440-022-00541-7",{"id":4129,"text":4130,"url":4131,"identifiers":4132},"4e588b03-8e33-42ca-bab3-8fce56e20e4e","Niu, 2018, Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism, J Hepatol, 68, 922, 10.1016\u002Fj.jhep.2017.12.007","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0168827817324893",{"doi":4133},"10.1016\u002Fj.jhep.2017.12.007",{"id":4135,"text":4136,"url":4137,"identifiers":4138},"bf27a53e-8e12-4a19-a035-7adb2a5a631f","Wang, 2021, Restoration of HBV-specific CD8(+) T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-alpha therapy, Signal Transduct Target Ther, 6, 376, 10.1038\u002Fs41392-021-00776-0","https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fs41392-021-00776-0",{"doi":4139},"10.1038\u002Fs41392-021-00776-0",{"id":4141,"text":4142,"url":4143,"identifiers":4144},"5ff6dc0a-c1b0-472b-a6a2-c7767ee9470e","Rose-John, 2018, Interleukin-6 family cytokines, Cold Spring Harb Perspect Biol, 10, a028415, 10.1101\u002Fcshperspect.a028415","http:\u002F\u002Fcshperspectives.cshlp.org\u002Flookup\u002Fdoi\u002F10.1101\u002Fcshperspect.a028415",{"doi":4145},"10.1101\u002Fcshperspect.a028415",{"id":4147,"text":4148,"url":4149,"identifiers":4150},"9a1125c6-3140-4f3c-81ef-5fe7814379cd","Hosel, 2009, Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection, Hepatology, 50, 1773, 10.1002\u002Fhep.23226","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fhep.23226",{"doi":4151},"10.1002\u002Fhep.23226",{"id":4153,"text":4154,"url":4155,"identifiers":4156},"7717b54c-c28e-4420-b74e-b27d69cb4c66","Larrea, 2014, Characterization of the CD40L\u002Foncostatin M\u002Foncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection, J Hepatol, 60, 482, 10.1016\u002Fj.jhep.2013.10.016","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS0168827813007411",{"doi":4157},"10.1016\u002Fj.jhep.2013.10.016",{"id":4159,"text":4160,"url":4161,"identifiers":4162},"968f2f5f-ec3a-4dc7-a3a5-5d01f443f33f","Carneros, 2019, Cardiotrophin-1 is an anti-inflammatory cytokine and promotes IL-4-induced M2 macrophage polarization, FASEB J, 33, 7578, 10.1096\u002Ffj.201801563R","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002Fabs\u002F10.1096\u002Ffj.201801563R",{"doi":4163},"10.1096\u002Ffj.201801563r",{"id":4123,"text":4165,"url":4125,"identifiers":4166},"Palumbo, 2015, IL6 inhibits HBV transcription by targeting the epigenetic control of the nuclear cccDNA minichromosome, PLoS One, 10",{"doi":4127},{"id":26,"text":4168,"url":4169,"identifiers":4170},"Larrea, 2009, Oncostatin M enhances the antiviral effects of type I interferon and activates immunostimulatory functions in liver epithelial cells, J Virol, 83, 3298, 10.1128\u002FJVI.02167-08","https:\u002F\u002Fdoi.org\u002F10.1128\u002Fjvi.02167-08",{"mag":4171,"pmc":4172,"openalex":4173,"pm":4174,"doi":4175},"2071886635","2655580","W2071886635","19158240","10.1128\u002Fjvi.02167-08",{"id":4177,"text":4178,"url":4179,"identifiers":4180},"20669b60-777b-4c21-8ed9-10a1e0141403","Larrea, 2014, Dysregulation of interferon regulatory factors impairs the expression of immunostimulatory molecules in hepatitis C virus genotype 1-infected hepatocytes, Gut, 63, 665, 10.1136\u002Fgutjnl-2012-304377","https:\u002F\u002Fgut.bmj.com\u002Flookup\u002Fdoi\u002F10.1136\u002Fgutjnl-2012-304377",{"doi":4181},"10.1136\u002Fgutjnl-2012-304377",{"id":4183,"text":4184,"url":4185,"identifiers":4186},"93cd1ddb-e2cd-419a-98a6-a87ee7c10ce5","Giraldez, 2021, New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology, Nat Rev Gastroenterol Hepatol, 18, 787, 10.1038\u002Fs41575-021-00473-x","https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fs41575-021-00473-x",{"doi":4187},"10.1038\u002Fs41575-021-00473-x",{"id":4189,"text":4190,"url":4191,"identifiers":4192},"e469fd2c-da4b-4ea3-b419-49c91d79a871","Tseng, 2022, The predictive role of hepatitis B biomarkers on HBV reactivation following direct-acting antiviral therapy in HBV\u002FHCV coinfected patients, Viruses, 14, 1812, 10.3390\u002Fv14081812","https:\u002F\u002Fwww.mdpi.com\u002F1999-4915\u002F14\u002F8\u002F1812",{"doi":4193},"10.3390\u002Fv14081812",{"id":4123,"text":4195,"url":4125,"identifiers":4196},"Tan, 2018, When hepatitis B virus meets interferons, Front Microbiol, 9, 1611, 10.3389\u002Ffmicb.2018.01611",{"doi":4127},{"id":26,"text":4198,"url":4199,"identifiers":4200},"Narayana, 2015, The interferon-induced transmembrane proteins, IFITM1, IFITM2, and IFITM3 inhibit hepatitis C virus entry, J Biol Chem, 290, 25946, 10.1074\u002Fjbc.M115.657346","https:\u002F\u002Fdoi.org\u002F10.1074\u002Fjbc.m115.657346",{"mag":4201,"pmc":4202,"openalex":4203,"pm":4204,"doi":4205},"1753997046","4646249","W1753997046","26354436","10.1074\u002Fjbc.m115.657346",{"id":4207,"text":4208,"url":4209,"identifiers":4210},"d4c7be84-6ac6-4bc7-878b-7f395ba3afba","Li, 2019, Human hepatitis B virus core protein inhibits IFNalpha-induced IFITM1 expression by interacting with BAF200, Viruses, 11, 427, 10.3390\u002Fv11050427","https:\u002F\u002Fwww.mdpi.com\u002F1999-4915\u002F11\u002F5\u002F427",{"doi":4211},"10.3390\u002Fv11050427",{"id":4213,"text":4214,"url":4215,"identifiers":4216},"c71686f4-61bf-4a51-8551-d538f4586302","Wong, 2022, How to achieve functional cure of HBV: stopping NUCs, adding interferon or new drug development?, J Hepatol, 76, 1249, 10.1016\u002Fj.jhep.2021.11.024","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS0168827821022339",{"doi":4217},"10.1016\u002Fj.jhep.2021.11.024",{"id":4219,"text":4220,"url":4221,"identifiers":4222},"f702e476-651f-4112-a50d-9ac9190e73e6","Luo, 2016, Hepatic oncostatin M receptor beta regulates obesity-induced steatosis and insulin resistance, Am J Pathol, 186, 1278, 10.1016\u002Fj.ajpath.2015.12.028","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0002944016001012",{"doi":4223},"10.1016\u002Fj.ajpath.2015.12.028",{"id":4225,"text":4226,"url":4227,"identifiers":4228},"4a51b43b-cfbd-4ae1-aa9a-4f3676c9b45d","Nakamura, 2004, Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice, Hepatology, 39, 635, 10.1002\u002Fhep.20086","https:\u002F\u002Fonlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Fhep.20086",{"doi":4229},"10.1002\u002Fhep.20086",{"id":4231,"text":4232,"url":4233,"identifiers":4234},"ea690a35-9450-4996-9bd1-63a9149842df","Kurash, 2004, Induction and regulation of acute phase proteins in transdifferentiated hepatocytes, Exp Cell Res, 292, 342, 10.1016\u002Fj.yexcr.2003.09.002","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS0014482703004713",{"doi":4235},"10.1016\u002Fj.yexcr.2003.09.002",{"id":4237,"text":4238,"url":4239,"identifiers":4240},"8602397c-9cac-462b-a1d8-6d71f837862a","Guerriero, 2009, Narrative-based computational modelling of the Gp130\u002FJAK\u002FSTAT signalling pathway, BMC Syst Biol, 3, 40, 10.1186\u002F1752-0509-3-40","https:\u002F\u002Fbmcsystbiol.biomedcentral.com\u002Farticles\u002F10.1186\u002F1752-0509-3-40",{"doi":4241},"10.1186\u002F1752-0509-3-40",{"id":4243,"text":4244,"url":4245,"identifiers":4246},"9e4de87a-9815-4fa2-b5c0-d02177d870ab","de Souza, 2022, Stimulation of osteoclast formation by oncostatin M and the role of WNT16 as a negative feedback regulator, Int J Mol Sci, 23, 3287, 10.3390\u002Fijms23063287","https:\u002F\u002Fwww.mdpi.com\u002F1422-0067\u002F23\u002F6\u002F3287",{"doi":4247},"10.3390\u002Fijms23063287",{"id":4249,"text":4250,"url":4251,"identifiers":4252},"7e3618a7-6109-4a4d-97c4-37bc96d70b7e","Hermanns, 2015, Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology, Cytokine Growth Factor Rev, 26, 545, 10.1016\u002Fj.cytogfr.2015.07.006","https:\u002F\u002Flinkinghub.elsevier.com\u002Fretrieve\u002Fpii\u002FS1359610115000544",{"doi":4253},"10.1016\u002Fj.cytogfr.2015.07.006",{"id":4255,"text":4256,"url":4257,"identifiers":4258},"fad5c803-9ad1-4e6a-b5e8-72a323de9c6d","You, 2022, Regulation of pattern-recognition receptor signaling by HBX during hepatitis B virus infection, Front Immunol, 13, 10.3389\u002Ffimmu.2022.829923","https:\u002F\u002Fwww.frontiersin.org\u002Farticles\u002F10.3389\u002Ffimmu.2022.829923\u002Ffull",{"doi":4259},"10.3389\u002Ffimmu.2022.829923",{"id":4261,"text":4262,"url":4263,"identifiers":4264},"7003f8db-7761-4415-91e2-c86f15109958","Mesev, 2019, Decoding type I and III interferon signalling during viral infection, Nat Microbiol, 4, 914, 10.1038\u002Fs41564-019-0421-x","https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fs41564-019-0421-x",{"doi":4265},"10.1038\u002Fs41564-019-0421-x",{"id":4123,"text":4267,"url":4125,"identifiers":4268},"Tsuno, 2009, IRF9 is a key factor for eliciting the antiproliferative activity of IFN-alpha, J Immunother, 32, 803",{"doi":4127},{"id":4270,"text":4271,"url":4272,"identifiers":4273},"afe65c7e-44c2-460b-b019-332e891d7dea","Winkler, 2019, Analysis of IFITM-IFITM interactions by a flow cytometry-based FRET assay, Int J Mol Sci, 20, 3859, 10.3390\u002Fijms20163859","https:\u002F\u002Fwww.mdpi.com\u002F1422-0067\u002F20\u002F16\u002F3859",{"doi":4274},"10.3390\u002Fijms20163859",{"id":4123,"text":4276,"url":4125,"identifiers":4277},"Song, 2022, Differential transcriptomics analysis of IPEC-J2 cells single or coinfected with porcine epidemic diarrhea virus and transmissible gastroenteritis virus, Front Immunol, 13",{"doi":4127},{"id":4279,"text":4280,"url":4281,"identifiers":4282},"6c61e910-ec86-4b56-bc96-144f4d799d40","Rajabi, 2018, MUC1-C activates polycomb repressive complexes and downregulates tumor suppressor genes in human cancer cells, Oncogene, 37, 2079, 10.1038\u002Fs41388-017-0096-9","https:\u002F\u002Fwww.nature.com\u002Farticles\u002Fs41388-017-0096-9",{"doi":4283},"10.1038\u002Fs41388-017-0096-9",{"id":4285,"text":4286,"url":4287,"identifiers":4288},"951e85f3-e3b8-4b3c-9eba-cdd16da33025","Salerno, 2020, Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene 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2011, Management of pediatric intestinal failure, Adv Pediatr, 58, 181, 10.1016\u002Fj.yapd.2011.03.012","https:\u002F\u002Fdoi.org\u002F10.1053\u002Fj.sempedsurg.2009.11.003",{"mag":4403,"openalex":4404,"pm":4405,"doi":4406},"2158017045","W2158017045","20123270","10.1053\u002Fj.sempedsurg.2009.11.003",{"id":26,"text":4408,"url":4409,"identifiers":4410},"Pironi, 2015, ESPEN endorsed recommendations. Definition and classification of intestinal failure in adults, Clin Nutr, 34, 171, 10.1016\u002Fj.clnu.2014.08.017","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.clnu.2014.08.017",{"mag":4411,"openalex":4412,"pm":4413,"doi":4414},"2138378318","W2138378318","25311444","10.1016\u002Fj.clnu.2014.08.017",{"id":26,"text":4416,"url":4417,"identifiers":4418},"Cole, 2010, The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responses, J Pediatr, 156, 941, 10.1016\u002Fj.jpeds.2009.12.008","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jpeds.2009.12.008",{"mag":4419,"pmc":4420,"openalex":4421,"pm":4422,"doi":4423},"2093226662","2875373","W2093226662","20171649","10.1016\u002Fj.jpeds.2009.12.008",{"id":4425,"text":4426,"url":4427,"identifiers":4428},"a3c62877-8cbb-4027-9e0a-602e4068c9d7","Wales, 2010, Short bowel syndrome: epidemiology and etiology, Semin Pediatr Surg, 19, 3, 10.1053\u002Fj.sempedsurg.2009.11.001","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS1055858609000614",{"doi":4429},"10.1053\u002Fj.sempedsurg.2009.11.001",{"id":26,"text":4431,"url":26,"identifiers":4432},"Sangild, 2014, Animal models of gastrointestinal and liver diseases. Animal models of infant short bowel syndrome: translational relevance and challenges, Am J Physiol Gastrointest Liver Physiol, 307, G1147, 10.1152\u002Fajpgi.00088.2014",{"doi":4433},"10.1152\u002Fajpgi.00088.2014",{"id":4435,"text":4436,"url":4437,"identifiers":4438},"fd22f485-0ba4-4d19-b125-8c9ee7838947","Helmrath, 1998, Enterocyte apoptosis is increased following small bowel resection, J Gastrointest Surg, 2, 44, 10.1016\u002FS1091-255X(98)80102-9","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS1091255X98801029",{"doi":4439},"10.1016\u002FS1091-255X(98)80102-9",{"id":4123,"text":4441,"url":4125,"identifiers":4442},"Dowling, 1967, Structural and functional changes following small intestinal resection in the rat, Clin Sci, 32, 139",{"doi":4127},{"id":26,"text":4444,"url":4445,"identifiers":4446},"Turner, 2011, Novel neonatal piglet models of surgical short bowel syndrome with intestinal failure, J Pediatr Gastroenterol Nutr, 52, 9, 10.1097\u002FMPG.0b013e3181f18ca0","https:\u002F\u002Fdoi.org\u002F10.1097\u002Fmpg.0b013e3181f18ca0",{"mag":4447,"openalex":4448,"pm":4449,"doi":4450},"2322226086","W2322226086","21119541","10.1097\u002Fmpg.0b013e3181f18ca0",{"id":26,"text":4452,"url":4453,"identifiers":4454},"Schall, 2015, Adult zebrafish intestine resection: a novel model of short bowel syndrome, adaptation, and intestinal stem cell regeneration, Am J Physiol Gastrointest Liver Physiol, 309, G135, 10.1152\u002Fajpgi.00311.2014","https:\u002F\u002Fdoi.org\u002F10.1152\u002Fajpgi.00311.2014",{"mag":4455,"pmc":4456,"openalex":4457,"pm":4458,"doi":4459},"1937309330","4525108","W1937309330","26089336","10.1152\u002Fajpgi.00311.2014",{"id":4461,"text":4462,"url":4463,"identifiers":4464},"b3fe0291-f635-4727-90d4-cca7fb5a76d0","Sigalet, 1998, Mechanisms underlying intestinal adaptation after massive intestinal resection in the rat, J Pediatr Surg, 33, 889, 10.1016\u002FS0022-3468(98)90667-4","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0022346898906674",{"doi":4465},"10.1016\u002Fs0022-3468(98)90667-4",{"id":26,"text":4467,"url":4468,"identifiers":4469},"Dekaney, 2007, Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in mice, Am J Physiol Gastrointest Liver Physiol, 293, G1013, 10.1152\u002Fajpgi.00218.2007","https:\u002F\u002Fdoi.org\u002F10.1152\u002Fajpgi.00218.2007",{"mag":4470,"openalex":4471,"pm":4472,"doi":4473},"2015274943","W2015274943","17855764","10.1152\u002Fajpgi.00218.2007",{"id":26,"text":4475,"url":4476,"identifiers":4477},"Gillingham, 2000, Differential jejunal and colonic adaptation due to resection and IGF-I in parenterally fed rats, Am J Physiol Gastrointest Liver Physiol, 278, G700, 10.1152\u002Fajpgi.2000.278.5.G700","https:\u002F\u002Fdoi.org\u002F10.1152\u002Fajpgi.2000.278.5.g700",{"mag":4478,"openalex":4479,"pm":4480,"doi":4481},"2286656038","W2286656038","10801262","10.1152\u002Fajpgi.2000.278.5.g700",{"id":26,"text":4483,"url":4484,"identifiers":4485},"Vegge, 2013, Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates, Am J Physiol Gastrointest Liver Physiol, 305, G277, 10.1152\u002Fajpgi.00064.2013","https:\u002F\u002Fdoi.org\u002F10.1152\u002Fajpgi.00064.2013",{"mag":4486,"pmc":4487,"openalex":4488,"pm":4489,"doi":4490},"2112358991","4073902","W2112358991","23764891","10.1152\u002Fajpgi.00064.2013",{"id":26,"text":4492,"url":4493,"identifiers":4494},"Aunsholt, 2015, Prematurity reduces functional adaptation to intestinal resection in piglets, JPEN J Parenter Enteral Nutr, 39, 668, 10.1177\u002F0148607114528714","https:\u002F\u002Fdoi.org\u002F10.1177\u002F0148607114528714",{"mag":4495,"openalex":4496,"pm":4497,"doi":4498},"2131232342","W2131232342","24687966","10.1177\u002F0148607114528714",{"id":26,"text":4500,"url":4501,"identifiers":4502},"Helmrath, 2007, Rapid expansion of intestinal secretory lineages following a massive small bowel resection in mice, Am J Physiol Gastrointest Liver Physiol, 292, G215, 10.1152\u002Fajpgi.00188.2006","https:\u002F\u002Fdoi.org\u002F10.1152\u002Fajpgi.00188.2006",{"mag":4503,"openalex":4504,"pm":4505,"doi":4506},"2124407730","W2124407730","16920699","10.1152\u002Fajpgi.00188.2006",{"id":26,"text":4508,"url":4509,"identifiers":4510},"Martin, 2009, Intestinal resection induces angiogenesis within adapting intestinal villi, J Pediatr Surg, 44, 1077, 10.1016\u002Fj.jpedsurg.2009.02.036","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jpedsurg.2009.02.036",{"mag":4511,"pmc":4512,"openalex":4513,"pm":4514,"doi":4515},"2008049702","2697129","W2008049702","19524720","10.1016\u002Fj.jpedsurg.2009.02.036",{"id":4517,"text":4518,"url":4519,"identifiers":4520},"930ed531-2af7-4fc4-b432-f519fea9aaa9","Rowland, 2012, Immediate alterations in intestinal oxygen saturation and blood flow after massive small bowel resection as measured by photoacoustic microscopy, J Pediatr Surg, 47, 1143, 10.1016\u002Fj.jpedsurg.2012.03.020","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0022346812002606",{"doi":4521},"10.1016\u002Fj.jpedsurg.2012.03.020",{"id":26,"text":4523,"url":4524,"identifiers":4525},"Tappenden, 2014, Intestinal adaptation following resection, JPEN J Parenter Enteral Nutr, 38, 23S, 10.1177\u002F0148607114525210","https:\u002F\u002Fdoi.org\u002F10.1177\u002F0148607114525210",{"mag":4526,"openalex":4527,"pm":4528,"doi":4529},"2030746522","W2030746522","24586019","10.1177\u002F0148607114525210",{"id":26,"text":4531,"url":4532,"identifiers":4533},"Weale, 2005, Intestinal adaptation after massive intestinal resection, Postgrad Med J, 81, 178, 10.1136\u002Fpgmj.2004.023846","https:\u002F\u002Fdoi.org\u002F10.1136\u002Fpgmj.2004.023846",{"mag":4534,"pmc":4535,"openalex":4536,"pm":4537,"doi":4538},"2071383864","1743223","W2071383864","15749794","10.1136\u002Fpgmj.2004.023846",{"id":26,"text":4540,"url":26,"identifiers":4541},"Thompson, 1995, Surgical approach to short-bowel syndrome. Experience in a population of 160 patients, Ann Surg, 222, 600, 10.1097\u002F00000658-199522240-00016",{"doi":4542},"10.1097\u002F00000658-199522240-00016",{"id":4544,"text":4545,"url":4546,"identifiers":4547},"89b70bff-bcfb-4f56-93a7-b7cf0d24505e","McDuffie, 2011, Intestinal adaptation after small bowel resection in human infants, J Pediatr Surg, 46, 1045, 10.1016\u002Fj.jpedsurg.2011.03.027","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0022346811002429",{"doi":4548},"10.1016\u002Fj.jpedsurg.2011.03.027",{"id":4550,"text":4551,"url":4552,"identifiers":4553},"ccb1d3b4-c094-423d-9571-01666d87d08d","Doldi, 1991, Intestinal adaptation following jejuno-ileal bypass, Clin Nutr, 10, 138, 10.1016\u002F0261-5614(91)90049-I","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002F026156149190049I",{"doi":4554},"10.1016\u002F0261-5614(91)90049-i",{"id":26,"text":4556,"url":4557,"identifiers":4558},"Joly, 2010, Drastic changes in fecal and mucosa-associated microbiota in adult patients with short bowel syndrome, Biochimie, 92, 753, 10.1016\u002Fj.biochi.2010.02.015","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.biochi.2010.02.015",{"mag":4559,"openalex":4560,"pm":4561,"doi":4562},"2084831309","W2084831309","20172013","10.1016\u002Fj.biochi.2010.02.015",{"id":26,"text":4564,"url":4565,"identifiers":4566},"O'Keefe, 1994, Long-acting somatostatin analogue therapy and protein metabolism in patients with jejunostomies, Gastroenterology, 107, 379, 10.1016\u002F0016-5085(94)90162-7","https:\u002F\u002Fdoi.org\u002F10.1016\u002F0016-5085(94)90162-7",{"mag":4567,"openalex":4568,"pm":4569,"doi":4570},"1570464416","W1570464416","7518781","10.1016\u002F0016-5085(94)90162-7",{"id":4572,"text":4573,"url":4574,"identifiers":4575},"fa1c543b-2e49-4325-af59-31a5b8303a3a","Ziegler, 2002, Distribution of the H+\u002Fpeptide transporter PepT1 in human intestine: up-regulated expression in the colonic mucosa of patients with short-bowel syndrome, Am J Clin Nutr, 75, 922, 10.1093\u002Fajcn\u002F75.5.922","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0002916523062159",{"doi":4576},"10.1093\u002Fajcn\u002F75.5.922",{"id":4123,"text":4578,"url":4125,"identifiers":4579},"Scott, 1998, GLP-2 augments the adaptive response to massive intestinal resection in rat, Am J Physiol, 275, G911",{"doi":4127},{"id":26,"text":4581,"url":4582,"identifiers":4583},"Jeppesen, 2012, Teduglutide, a novel glucagon-like peptide 2 analog, in the treatment of patients with short bowel syndrome, Therap Adv Gastroenterol, 5, 159, 10.1177\u002F1756283X11436318","https:\u002F\u002Fdoi.org\u002F10.1177\u002F1756283x11436318",{"mag":4584,"pmc":4585,"openalex":4586,"pm":4587,"doi":4588},"2118800902","3342570","W2118800902","22570676","10.1177\u002F1756283x11436318",{"id":26,"text":4590,"url":4591,"identifiers":4592},"Jeppesen, 2011, Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and\u002For intravenous fluid requirements in patients with short bowel syndrome, Gut, 60, 902, 10.1136\u002Fgut.2010.218271","https:\u002F\u002Fdoi.org\u002F10.1136\u002Fgut.2010.218271",{"mag":4593,"pmc":4594,"openalex":4595,"pm":4596,"doi":4597},"2098309233","3112364","W2098309233","21317170","10.1136\u002Fgut.2010.218271",{"id":26,"text":4599,"url":4600,"identifiers":4601},"Seidner, 2013, Increased intestinal absorption in the era of teduglutide and its impact on management strategies in patients with short bowel syndrome-associated intestinal failure, JPEN J Parenter Enteral Nutr, 37, 201, 10.1177\u002F0148607112472906","https:\u002F\u002Fdoi.org\u002F10.1177\u002F0148607112472906",{"mag":4602,"openalex":4603,"pm":4604,"doi":4605},"2123771704","W2123771704","23343999","10.1177\u002F0148607112472906",{"id":26,"text":4607,"url":4608,"identifiers":4609},"Jeppesen, 2001, Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon, Gastroenterology, 120, 806, 10.1053\u002Fgast.2001.22555","https:\u002F\u002Fdoi.org\u002F10.1053\u002Fgast.2001.22555",{"mag":4610,"openalex":4611,"pm":4612,"doi":4613},"2127068727","W2127068727","11231933","10.1053\u002Fgast.2001.22555",{"id":26,"text":4615,"url":4616,"identifiers":4617},"Jeppesen, 2005, Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients, Gut, 54, 1224, 10.1136\u002Fgut.2004.061440","https:\u002F\u002Fdoi.org\u002F10.1136\u002Fgut.2004.061440",{"mag":4618,"pmc":4619,"openalex":4620,"pm":4621,"doi":4622},"2109745718","1774653","W2109745718","16099790","10.1136\u002Fgut.2004.061440",{"id":4624,"text":4625,"url":4626,"identifiers":4627},"d2011ddd-c41e-4570-8095-b6e5eea342de","Jeppesen, 2012, Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure, Gastroenterology, 143, 1473, 10.1053\u002Fj.gastro.2012.09.007","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0016508512013169",{"doi":4628},"10.1053\u002Fj.gastro.2012.09.007",{"id":4630,"text":4631,"url":4632,"identifiers":4633},"f90d12ec-57e4-430b-b0f9-eaa6e31bae8a","Madsen, 2013, Acute effects of continuous infusions of glucagon-like peptide (GLP)-1, GLP-2 and the combination (GLP-1+GLP-2) on intestinal absorption in short bowel syndrome (SBS) patients. A placebo-controlled study, Regul Pept, 184, 30, 10.1016\u002Fj.regpep.2013.03.025","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0167011513000633",{"doi":4634},"10.1016\u002Fj.regpep.2013.03.025",{"id":26,"text":4636,"url":4637,"identifiers":4638},"Sigalet, 2004, GLP-2 levels in infants with intestinal dysfunction, Pediatr Res, 56, 371, 10.1203\u002F01.PDR.0000134250.80492.EC","https:\u002F\u002Fdoi.org\u002F10.1203\u002F01.pdr.0000134250.80492.ec",{"mag":4639,"openalex":4640,"pm":4641,"doi":4642},"2085424664","W2085424664","15201402","10.1203\u002F01.pdr.0000134250.80492.ec",{"id":26,"text":4644,"url":4645,"identifiers":4646},"Tappenden, 2013, Teduglutide enhances structural adaptation of the small intestinal mucosa in patients with short bowel syndrome, J Clin Gastroenterol, 47, 602, 10.1097\u002FMCG.0b013e3182828f57","https:\u002F\u002Fdoi.org\u002F10.1097\u002Fmcg.0b013e3182828f57",{"mag":4647,"openalex":4648,"pm":4649,"doi":4650},"2320948890","W2320948890","23426461","10.1097\u002Fmcg.0b013e3182828f57",{"id":26,"text":4652,"url":4653,"identifiers":4654},"Schwartz, 2016, Long-term teduglutide for the treatment of patients with intestinal failure associated with short bowel syndrome, Clin Transl Gastroenterol, 7, e142, 10.1038\u002Fctg.2015.69","https:\u002F\u002Fdoi.org\u002F10.1038\u002Fctg.2015.69",{"mag":4655,"pmc":4656,"openalex":4657,"pm":4658,"doi":4659},"2345590243","4817413","W2345590243","26844839","10.1038\u002Fctg.2015.69",{"id":26,"text":4661,"url":4662,"identifiers":4663},"Watson, 2014, An in vivo model of human small intestine using pluripotent stem cells, Nat Med, 20, 1310, 10.1038\u002Fnm.3737","https:\u002F\u002Fdoi.org\u002F10.1038\u002Fnm.3737",{"mag":4664,"pmc":4665,"openalex":4666,"pm":4667,"doi":4668},"2031522785","4408376","W2031522785","25326803","10.1038\u002Fnm.3737",{"id":4670,"text":4671,"url":4672,"identifiers":4673},"e9dd0bb2-d9d0-4bf7-ac63-58a64ac6ae7f","Juno, 2002, A serum factor after intestinal resection stimulates epidermal growth factor receptor signaling and proliferation in intestinal epithelial cells, Surgery, 132, 377, 10.1067\u002Fmsy.2002.125724","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0039606002000995",{"doi":4674},"10.1067\u002Fmsy.2002.125724",{"id":26,"text":4676,"url":26,"identifiers":4677},"Tappenden, 2014, Pathophysiology of short bowel syndrome: considerations of resected and residual anatomy, JPEN J Parenter Enteral Nutr, 38, 14S, 10.1177\u002F0148607113520005",{"doi":4678},"10.1177\u002F0148607113520005",{"id":26,"text":4680,"url":4681,"identifiers":4682},"Goulet, 2005, Outcome and long-term growth after extensive small bowel resection in the neonatal period: a survey of 87 children, Eur J Pediatr Surg, 15, 95, 10.1055\u002Fs-2004-821214","https:\u002F\u002Fdoi.org\u002F10.1055\u002Fs-2004-821214",{"mag":4683,"openalex":4684,"pm":4685,"doi":4686},"2014313715","W2014313715","15877257","10.1055\u002Fs-2004-821214",{"id":26,"text":4688,"url":4689,"identifiers":4690},"Nordgaard, 1994, Colon as a digestive organ in patients with short bowel, Lancet, 343, 373, 10.1016\u002FS0140-6736(94)91220-3","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fs0140-6736(94)91220-3",{"mag":4691,"openalex":4692,"pm":4693,"doi":4694},"2120068675","W2120068675","7905549","10.1016\u002Fs0140-6736(94)91220-3",{"id":26,"text":4696,"url":4697,"identifiers":4698},"McMellen, 2010, Growth factors: possible roles for clinical management of the short bowel syndrome, Semin Pediatr Surg, 19, 35, 10.1053\u002Fj.sempedsurg.2009.11.010","https:\u002F\u002Fdoi.org\u002F10.1053\u002Fj.sempedsurg.2009.11.010",{"mag":4699,"pmc":4700,"openalex":4701,"pm":4702,"doi":4703},"2003855652","2891767","W2003855652","20123272","10.1053\u002Fj.sempedsurg.2009.11.010",{"id":4705,"text":4706,"url":4707,"identifiers":4708},"61916268-cf71-473d-8ef1-ff1650b35e86","Warner, 2016, The pathogenesis of resection-associated intestinal adaptation, Cell Mol Gastroenterol Hepatol, 2, 429, 10.1016\u002Fj.jcmgh.2016.05.001","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS2352345X16300418",{"doi":4709},"10.1016\u002Fj.jcmgh.2016.05.001",{"id":4711,"text":4712,"url":4713,"identifiers":4714},"e44f00b0-76c9-4def-8271-40975d164ab7","Scolapio, 1997, Effect of growth hormone, glutamine, and diet on adaptation in short-bowel syndrome: a randomized, controlled study, Gastroenterology, 113, 1074, 10.1053\u002Fgast.1997.v113.pm9322500","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0016508597004575",{"doi":4715},"10.1053\u002Fgast.1997.v113.pm9322500",{"id":26,"text":4717,"url":4718,"identifiers":4719},"Nucci, 2004, Results of growth trophic therapy in children with short bowel syndrome, J Pediatr Surg, 39, 335, 10.1016\u002Fj.jpedsurg.2003.11.022","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jpedsurg.2003.11.022",{"mag":4720,"openalex":4721,"pm":4722,"doi":4723},"1966704651","W1966704651","15017548","10.1016\u002Fj.jpedsurg.2003.11.022",{"id":26,"text":4725,"url":4726,"identifiers":4727},"Goulet, 2010, Effect of recombinant human growth hormone on intestinal absorption and body composition in children with short bowel syndrome, JPEN J Parenter Enteral Nutr, 34, 513, 10.1177\u002F0148607110362585","https:\u002F\u002Fdoi.org\u002F10.1177\u002F0148607110362585",{"mag":4728,"openalex":4729,"pm":4730,"doi":4731},"2031091559","W2031091559","20852179","10.1177\u002F0148607110362585",{"id":26,"text":4733,"url":4734,"identifiers":4735},"Guo, 2016, Early intestinal rehabilitation therapy ameliorates intestinal adaptation in children with short bowel syndrome: the long-term outcome, Am Surg, 82, 1215, 10.1177\u002F000313481608201229","https:\u002F\u002Fdoi.org\u002F10.1177\u002F000313481608201229",{"mag":4736,"openalex":4737,"pm":4738,"doi":4739},"3024216703","W3024216703","28234187","10.1177\u002F000313481608201229",{"id":26,"text":4741,"url":4742,"identifiers":4743},"Byrne, 2005, Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome, Ann Surg, 242, 655, 10.1097\u002F01.sla.0000186479.53295.14","https:\u002F\u002Fdoi.org\u002F10.1097\u002F01.sla.0000186479.53295.14",{"mag":4744,"pmc":4745,"openalex":4746,"pm":4747,"doi":4748},"2038966013","1409868","W2038966013","16244538","10.1097\u002F01.sla.0000186479.53295.14",{"id":26,"text":4750,"url":4751,"identifiers":4752},"Gu, 2001, Effects of growth hormone (rhGH) and glutamine supplemented parenteral nutrition on intestinal adaptation in short bowel rats, Clin Nutr, 20, 159, 10.1054\u002Fclnu.2000.0379","https:\u002F\u002Fdoi.org\u002F10.1054\u002Fclnu.2000.0379",{"mag":4753,"openalex":4754,"pm":4755,"doi":4756},"2055080997","W2055080997","11327744","10.1054\u002Fclnu.2000.0379",{"id":4758,"text":4759,"url":4760,"identifiers":4761},"bbc817b7-711b-4314-893d-51145e392c12","Sigalet, 2005, A pilot study of the use of epidermal growth factor in pediatric short bowel syndrome, J Pediatr Surg, 40, 763, 10.1016\u002Fj.jpedsurg.2005.01.038","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS002234680500076X",{"doi":4762},"10.1016\u002Fj.jpedsurg.2005.01.038",{"id":4123,"text":4764,"url":4125,"identifiers":4765},"Erwin, 1999, Intestinal overexpression of EGF in transgenic mice enhances adaptation after small bowel resection, Am J Physiol, 277, G533",{"doi":4127},{"id":4767,"text":4768,"url":4769,"identifiers":4770},"1ebc6685-e2b9-485a-8ed0-87777f88a683","Shin, 1998, Epidermal growth factor augments adaptation following small bowel resection: optimal dosage, route, and timing of administration, J Surg Res, 77, 11, 10.1006\u002Fjsre.1998.5336","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0022480498953367",{"doi":4771},"10.1006\u002Fjsre.1998.5336",{"id":26,"text":4773,"url":4774,"identifiers":4775},"Chaet, 1994, Epidermal growth factor enhances intestinal adaptation after massive small bowel resection, J Pediatr Surg, 29, 1035, 10.1016\u002F0022-3468(94)90274-7","https:\u002F\u002Fdoi.org\u002F10.1016\u002F0022-3468(94)90274-7",{"mag":4776,"openalex":4777,"pm":4778,"doi":4779},"2058766511","W2058766511","7965502","10.1016\u002F0022-3468(94)90274-7",{"id":26,"text":4781,"url":4782,"identifiers":4783},"Rowland, 2012, Enterocyte expression of epidermal growth factor receptor is not required for intestinal adaptation in response to massive small bowel resection, J Pediatr Surg, 47, 1748, 10.1016\u002Fj.jpedsurg.2012.03.089","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jpedsurg.2012.03.089",{"mag":4784,"pmc":4785,"openalex":4786,"pm":4787,"doi":4788},"2024484290","3443391","W2024484290","22974617","10.1016\u002Fj.jpedsurg.2012.03.089",{"id":4790,"text":4791,"url":4792,"identifiers":4793},"daf69aa4-0ba3-4cf6-9bdb-2e83a22ec978","Sun, 2014, Insulin-like growth factor 2 and its enterocyte receptor are not required for adaptation in response to massive small bowel resection, J Pediatr Surg, 49, 966, 10.1016\u002Fj.jpedsurg.2014.01.035","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS002234681400044X",{"doi":4794},"10.1016\u002Fj.jpedsurg.2014.01.035",{"id":26,"text":4796,"url":4797,"identifiers":4798},"Lim, 2017, Synergy of glucagon-like peptide-2 and epidermal growth factor coadministration on intestinal adaptation in neonatal piglets with short bowel syndrome, Am J Physiol Gastrointest Liver Physiol, 312, G390, 10.1152\u002Fajpgi.00281.2016","https:\u002F\u002Fdoi.org\u002F10.1152\u002Fajpgi.00281.2016",{"mag":4799,"openalex":4800,"pm":4801,"doi":4802},"2573141020","W2573141020","28104586","10.1152\u002Fajpgi.00281.2016",{"id":4123,"text":4804,"url":4125,"identifiers":4805},"Martin, 2004, Glucagon-like peptide-2 induces intestinal adaption in parenterally fed rats with short bowel syndrome, Am J Physiol, 286, G964",{"doi":4127},{"id":26,"text":4807,"url":4808,"identifiers":4809},"Lim, 2016, Differential effects on intestinal adaptation following exogenous glucagon-like peptide 2 therapy with and without enteral nutrition in neonatal short bowel syndrome, JPEN J Parenter Enteral Nutr, 41, 156, 10.1177\u002F0148607116665812","https:\u002F\u002Fdoi.org\u002F10.1177\u002F0148607116665812",{"mag":4810,"openalex":4811,"pm":4812,"doi":4813},"2523581817","W2523581817","27660290","10.1177\u002F0148607116665812",{"id":26,"text":4815,"url":4816,"identifiers":4817},"Drucker, 1996, Induction of intestinal epithelial proliferation by glucagon-like peptide 2, Proc Natl Acad Sci U S A, 93, 7911, 10.1073\u002Fpnas.93.15.7911","https:\u002F\u002Fdoi.org\u002F10.1073\u002Fpnas.93.15.7911",{"mag":4818,"pmc":4819,"openalex":4820,"pm":4821,"doi":4822},"2013395086","38848","W2013395086","8755576","10.1073\u002Fpnas.93.15.7911",{"id":4123,"text":4824,"url":4125,"identifiers":4825},"Tsai, 1997, Intestinal growth-promoting properties of glucagon-like 2 in mice, Am J Physiol, 273, E77",{"doi":4127},{"id":4827,"text":4828,"url":4829,"identifiers":4830},"46adca47-f781-4c7b-94d4-e7dae87b65bc","Sigalet, 2006, Glucagon-like peptide-2 induces a specific pattern of adaptation in remnant jejunum, Dig Dis Sci, 51, 1557, 10.1007\u002Fs10620-006-9077-5","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs10620-006-9077-5",{"doi":4831},"10.1007\u002Fs10620-006-9077-5",{"id":26,"text":4833,"url":4834,"identifiers":4835},"Garrison, 2009, Early but not late administration of glucagon-like peptide-2 following ileo-cecal resection augments putative intestinal stem cell expansion, Am J Physiol Gastrointest Liver Physiol, 296, G643, 10.1152\u002Fajpgi.90588.2008","https:\u002F\u002Fdoi.org\u002F10.1152\u002Fajpgi.90588.2008",{"mag":4836,"pmc":4837,"openalex":4838,"pm":4839,"doi":4840},"1978770979","2660180","W1978770979","19118113","10.1152\u002Fajpgi.90588.2008",{"id":26,"text":4842,"url":4843,"identifiers":4844},"Naberhuis, 2017, Teduglutide-stimulated intestinal adaptation is complemented and synergistically enhanced by partial enteral nutrition in a neonatal piglet model of short bowel syndrome, JPEN J Parenter Enteral Nutr, 41, 853, 10.1177\u002F0148607115602891","https:\u002F\u002Fdoi.org\u002F10.1177\u002F0148607115602891",{"mag":4845,"openalex":4846,"pm":4847,"doi":4848},"1667790448","W1667790448","26304601","10.1177\u002F0148607115602891",{"id":26,"text":4850,"url":4851,"identifiers":4852},"Krsek, 2002, Plasma ghrelin levels in patients with short bowel syndrome, Endocr Res, 28, 10.1081\u002FERC-120004535","http:\u002F\u002Fdx.doi.org\u002F10.1016\u002Fj.clnesp.2023.09.513",{"doi":4853},"10.1016\u002Fj.clnesp.2023.09.513",{"id":26,"text":4855,"url":4856,"identifiers":4857},"Lund, 1998, Molecular basis of intestinal adaptation: the role of the insulin-like growth factor system, Ann N Y Acad Sci, 859, 18, 10.1111\u002Fj.1749-6632.1998.tb11108.x","https:\u002F\u002Fdoi.org\u002F10.1111\u002Fj.1749-6632.1998.tb11108.x",{"mag":4858,"openalex":4859,"pm":4860,"doi":4861},"2127517789","W2127517789","9928367","10.1111\u002Fj.1749-6632.1998.tb11108.x",{"id":26,"text":4863,"url":4864,"identifiers":4865},"Knott, 2004, Smooth muscle overexpression of IGF-I induces a novel adaptive response to small bowel resection, Am J Physiol Gastrointest Liver Physiol, 287, G562, 10.1152\u002Fajpgi.00438.2003","https:\u002F\u002Fdoi.org\u002F10.1152\u002Fajpgi.00438.2003",{"mag":4866,"openalex":4867,"pm":4868,"doi":4869},"2128894380","W2128894380","15142831","10.1152\u002Fajpgi.00438.2003",{"id":26,"text":4871,"url":4872,"identifiers":4873},"Dahly, 2003, IGF-I augments resection-induced mucosal hyperplasia by altering enterocyte kinetics, Am J Physiol Regul Integr Comp Physiol, 285, R800, 10.1152\u002Fajpregu.00014.2003","https:\u002F\u002Fdoi.org\u002F10.1152\u002Fajpregu.00014.2003",{"mag":4874,"openalex":4875,"pm":4876,"doi":4877},"2162542603","W2162542603","12763742","10.1152\u002Fajpregu.00014.2003",{"id":26,"text":4879,"url":4880,"identifiers":4881},"Vanderhoof, 1992, Truncated and native insulin like growth factor I enhance mucosal adaptation after jejunoileal resection, Gastroenterology, 102, 1949, 10.1016\u002F0016-5085(92)90318-S","http:\u002F\u002Fdx.doi.org\u002F10.1016\u002F0016-5085(92)90318-s",{"doi":4882},"10.1016\u002F0016-5085(92)90318-s",{"id":26,"text":4884,"url":4885,"identifiers":4886},"Choi, 2013, IGF-2 mediates intestinal mucosal hyperplasia in retinoblastoma protein (Rb)-deficient mice, J Pediatr Surg, 48, 1340, 10.1016\u002Fj.jpedsurg.2013.03.042","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jpedsurg.2013.03.042",{"mag":4887,"pmc":4888,"openalex":4889,"pm":4890,"doi":4891},"2001323366","3885982","W2001323366","23845628","10.1016\u002Fj.jpedsurg.2013.03.042",{"id":26,"text":4893,"url":4894,"identifiers":4895},"Falcone, 1999, Intestinal adaptation occurs independent of transforming growth factor-alpha, J Pediatr Surg, 35, 365, 10.1016\u002FS0022-3468(00)90042-3","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fs0022-3468(00)90042-3",{"mag":4896,"openalex":4897,"pm":4898,"doi":4899},"2107836145","W2107836145","10693698","10.1016\u002Fs0022-3468(00)90042-3",{"id":4901,"text":4902,"url":4903,"identifiers":4904},"a7bd9737-cc7f-405a-b421-77c75be8b177","Sukhotnik, 2002, Effect of transforming growth factor-α on intestinal adaptation in a rat model of short bowel syndrome, J Surg Res, 108, 235, 10.1006\u002Fjsre.2002.6556","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS002248040296556X",{"doi":4905},"10.1006\u002Fjsre.2002.6556",{"id":4907,"text":4908,"url":4909,"identifiers":4910},"90ebfcfc-f683-49d0-97f4-e9323c9052cb","Sukhotnik, 2008, Responsiveness of intestinal epithelial cell turnover to TGF-alpha after bowel resection in a rat is correlated with EGF receptor expression along the villus-crypt axis, Pediatr Surg Int, 24, 21, 10.1007\u002Fs00383-007-2038-z","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00383-007-2038-z",{"doi":4911},"10.1007\u002Fs00383-007-2038-z",{"id":4913,"text":4914,"url":4915,"identifiers":4916},"ae33d692-0bf6-40b8-9b97-6100651ebaeb","Sukhotnik, 2006, Effect of leptin on intestinal re-growth following massive small bowel resection in rat, Pediatr Surg Int, 22, 9, 10.1007\u002Fs00383-005-1572-9","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs00383-005-1572-9",{"doi":4917},"10.1007\u002Fs00383-005-1572-9",{"id":26,"text":4919,"url":4920,"identifiers":4921},"Sukhotnik, 2009, Leptin affects intestinal epithelial cell turnover in correlation with leptin receptor expression along the villus-crypt axis after massive small bowel resection in a rat, Pediatr Res, 66, 648, 10.1203\u002FPDR.0b013e3181be9f84","https:\u002F\u002Fdoi.org\u002F10.1203\u002Fpdr.0b013e3181be9f84",{"mag":4922,"openalex":4923,"pm":4924,"doi":4925},"2038864556","W2038864556","19730157","10.1203\u002Fpdr.0b013e3181be9f84",{"id":4927,"text":4928,"url":4929,"identifiers":4930},"35bf487d-e597-4043-b24d-67c415b2e686","Pearson, 2001, Novel effect of leptin on small intestine adaptation, J Surg Res, 97, 192, 10.1006\u002Fjsre.2001.6153","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0022480401961530",{"doi":4931},"10.1006\u002Fjsre.2001.6153",{"id":26,"text":4933,"url":4934,"identifiers":4935},"Kiely, 2006, Altered small intestinal absorptive enzyme activities in leptin-deficient obese mice: influence of bowel resection, J Pediatr Surg, 41, 1243, 10.1016\u002Fj.jpedsurg.2006.03.047","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jpedsurg.2006.03.047",{"mag":4936,"openalex":4937,"pm":4938,"doi":4939},"2023365495","W2023365495","16818056","10.1016\u002Fj.jpedsurg.2006.03.047",{"id":26,"text":4941,"url":4942,"identifiers":4943},"Guyton, 2017, The gut microbiota and gastrointestinal surgery, Nat Rev Gastroenterol Hepatol, 14, 43, 10.1038\u002Fnrgastro.2016.139","https:\u002F\u002Fdoi.org\u002F10.1038\u002Fnrgastro.2016.139",{"mag":4944,"openalex":4945,"pm":4946,"doi":4947},"2531181477","W2531181477","27729657","10.1038\u002Fnrgastro.2016.139",{"id":26,"text":4949,"url":4950,"identifiers":4951},"Begley, 2005, The interaction between bacteria and bile, FEMS Microbiol Rev, 29, 625, 10.1016\u002Fj.femsre.2004.09.003","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.femsre.2004.09.003",{"mag":4952,"openalex":4953,"pm":4954,"doi":4955},"2162904770","W2162904770","16102595","10.1016\u002Fj.femsre.2004.09.003",{"id":26,"text":4957,"url":4958,"identifiers":4959},"Devine, 2013, Impact of ileocecal resection and concomitant antibiotics on the microbiome of the murine jejunum and colon, PLoS One, 8, e73140, 10.1371\u002Fjournal.pone.0073140","https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.pone.0073140",{"mag":4960,"pmc":4961,"openalex":4962,"pm":4963,"doi":4964},"1998316739","3754918","W1998316739","24015295","10.1371\u002Fjournal.pone.0073140",{"id":26,"text":4966,"url":4967,"identifiers":4968},"Lapthorne, 2013, Gut microbial diversity is reduced and is associated with colonic inflammation in a piglet model of short bowel syndrome, Gut Microbes, 4, 212, 10.4161\u002Fgmic.24372","https:\u002F\u002Fdoi.org\u002F10.4161\u002Fgmic.24372",{"mag":4969,"pmc":4970,"openalex":4971,"pm":4972,"doi":4973},"1988879028","3669166","W1988879028","23549027","10.4161\u002Fgmic.24372",{"id":26,"text":4975,"url":4976,"identifiers":4977},"Sommovilla, 2015, Small bowel resection induces long-term changes in the enteric microbiota of mice, J Gastrointest Surg, 19, 56, 10.1007\u002Fs11605-014-2631-0","https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs11605-014-2631-0",{"mag":4978,"pmc":4979,"openalex":4980,"pm":4981,"doi":4982},"2076832266","4576885","W2076832266","25183407","10.1007\u002Fs11605-014-2631-0",{"id":4984,"text":4985,"url":4986,"identifiers":4987},"b378b5c9-ee12-4c21-b570-d6e7022fb2bb","Engstrand Lilja, 2015, Intestinal dysbiosis in children with short bowel syndrome is associated with impaired outcome, Microbiome, 3, 18, 10.1186\u002Fs40168-015-0084-7","https:\u002F\u002Fmicrobiomejournal.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs40168-015-0084-7",{"doi":4988},"10.1186\u002Fs40168-015-0084-7",{"id":26,"text":4990,"url":4991,"identifiers":4992},"Korpela, 2017, Intestinal microbiota signatures associated with histological liver steatosis in pediatric-onset intestinal failure, JPEN J Parenter Enteral Nutr, 41, 238, 10.1177\u002F0148607115584388","https:\u002F\u002Fdoi.org\u002F10.1177\u002F0148607115584388",{"mag":4993,"openalex":4994,"pm":4995,"doi":4996},"1992875107","W1992875107","25934046","10.1177\u002F0148607115584388",{"id":26,"text":4998,"url":4999,"identifiers":5000},"Tolga Muftuoglu, 2011, Effects of probiotics on experimental short-bowel syndrome, Am J Surg, 202, 461, 10.1016\u002Fj.amjsurg.2011.03.005","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.amjsurg.2011.03.005",{"mag":5001,"openalex":5002,"pm":5003,"doi":5004},"2069515885","W2069515885","21722874","10.1016\u002Fj.amjsurg.2011.03.005",{"id":26,"text":5006,"url":5007,"identifiers":5008},"Mao, 1996, The effects of Lactobacillus strains and oat fiber on methotrexate-induced enterocolitis in rats, Gastroenterology, 111, 334, 10.1053\u002Fgast.1996.v111.pm8690198","https:\u002F\u002Fdoi.org\u002F10.1053\u002Fgast.1996.v111.pm8690198",{"mag":5009,"openalex":5010,"pm":5011,"doi":5012},"2081527168","W2081527168","8690198","10.1053\u002Fgast.1996.v111.pm8690198",{"id":26,"text":5014,"url":5015,"identifiers":5016},"Pereira-Fantini, 2017, Unravelling the metabolic impact of SBS-associated microbial dysbiosis: insights from the piglet short bowel syndrome model, Sci Rep, 7, 43326, 10.1038\u002Fsrep43326","https:\u002F\u002Fdoi.org\u002F10.1038\u002Fsrep43326",{"mag":5017,"pmc":5018,"openalex":5019,"pm":5020,"doi":5021},"2589697601","5322370","W2589697601","28230078","10.1038\u002Fsrep43326",{"id":26,"text":5023,"url":5024,"identifiers":5025},"Kamath, 1988, Short-chain fatty acids stimulate ileal motility in humans, Gastroenterology, 95, 1496, 10.1016\u002FS0016-5085(88)80068-4","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fs0016-5085(88)80068-4",{"mag":5026,"openalex":5027,"pm":5028,"doi":5029},"1939006853","W1939006853","3181675","10.1016\u002Fs0016-5085(88)80068-4",{"id":4123,"text":5031,"url":4125,"identifiers":5032},"Royall, 1992, Evidence for colonic conservation of malabsorbed carbohydrate in short bowel syndrome, Am J Gastroenterol, 87, 751",{"doi":4127},{"id":26,"text":5034,"url":5035,"identifiers":5036},"Sobhani, 2011, Microbial dysbiosis in colorectal cancer (CRC) patients, PLoS One, 6, e16393, 10.1371\u002Fjournal.pone.0016393","https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.pone.0016393",{"mag":5037,"pmc":5038,"openalex":5039,"pm":5040,"doi":5041},"2091564291","3029306","W2091564291","21297998","10.1371\u002Fjournal.pone.0016393",{"id":26,"text":1773,"url":26,"identifiers":5043},{"doi":1775},{"id":26,"text":5045,"url":5046,"identifiers":5047},"Mondot, 2016, Structural robustness of the gut mucosal microbiota is associated with Crohn's disease remission after surgery, Gut, 65, 954, 10.1136\u002Fgutjnl-2015-309184","http:\u002F\u002Fdx.doi.org\u002F10.1136\u002Fgutjnl-2015-309184",{"doi":5048},"10.1136\u002Fgutjnl-2015-309184",{"id":5050,"text":5051,"url":5052,"identifiers":5053},"a78b76f1-2780-4a71-b963-c6edf5849956","Shogan, 2014, Intestinal anastomotic injury alters spatially defined microbiome composition and function, Microbiome, 2, 35, 10.1186\u002F2049-2618-2-35","https:\u002F\u002Fmicrobiomejournal.biomedcentral.com\u002Farticles\u002F10.1186\u002F2049-2618-2-35",{"doi":5054},"10.1186\u002F2049-2618-2-35",{"id":26,"text":5056,"url":5057,"identifiers":5058},"Speck, 2011, Inflammation enhances resection-induced intestinal adaptive growth in IL-10 null mice, J Surg Res, 168, 62, 10.1016\u002Fj.jss.2009.09.051","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jss.2009.09.051",{"mag":5059,"pmc":5060,"openalex":5061,"pm":5062,"doi":5063},"2119708605","2889031","W2119708605","20074747","10.1016\u002Fj.jss.2009.09.051",{"id":26,"text":5065,"url":5066,"identifiers":5067},"Willing, 2007, Enterocyte proliferation and apoptosis in the caudal small intestine is influenced by the composition of colonizing commensal bacteria in the neonatal gnotobiotic pig, J Anim Sci, 85, 3256, 10.2527\u002Fjas.2007-0320","https:\u002F\u002Fdoi.org\u002F10.2527\u002Fjas.2007-0320",{"mag":5068,"openalex":5069,"pm":5070,"doi":5071},"2032876379","W2032876379","17785595","10.2527\u002Fjas.2007-0320",{"id":5073,"text":5074,"url":5075,"identifiers":5076},"042da8a2-6a31-41e9-a087-43dd8fb8a50b","Juno, 2003, Characterization of small bowel resection and intestinal adaptation in germ-free rats, Surgery, 134, 582, 10.1016\u002FS0039-6060(03)00281-2","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0039606003002812",{"doi":5077},"10.1016\u002Fs0039-6060(03)00281-2",{"id":26,"text":5079,"url":5080,"identifiers":5081},"Dekaney, 2008, Bacterial-dependent up-regulation of intestinal bile acid binding protein and transport is FXR-mediated following ileo-cecal resection, Surgery, 144, 174, 10.1016\u002Fj.surg.2008.03.035","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.surg.2008.03.035",{"mag":5082,"pmc":5083,"openalex":5084,"pm":5085,"doi":5086},"2166891888","2531249","W2166891888","18656623","10.1016\u002Fj.surg.2008.03.035",{"id":26,"text":5088,"url":5089,"identifiers":5090},"Banasaz, 2002, Increased enterocyte production in gnotobiotic rats mono-associated with Lactobacillus rhamnosus GG, Appl Environ Microbiol, 68, 3031, 10.1128\u002FAEM.68.6.3031-3034.2002","https:\u002F\u002Fdoi.org\u002F10.1128\u002Faem.68.6.3031-3034.2002",{"mag":5091,"pmc":5092,"openalex":5093,"pm":5094,"doi":5095},"2128797170","123962","W2128797170","12039764","10.1128\u002Faem.68.6.3031-3034.2002",{"id":26,"text":5097,"url":5098,"identifiers":5099},"Ichikawa, 1999, Probiotic bacteria stimulate gut epithelial cell proliferation in rat, Dig Dis Sci, 44, 2119, 10.1023\u002FA:1026647024077","https:\u002F\u002Fdoi.org\u002F10.1023\u002Fa:1026647024077",{"mag":5100,"openalex":5101,"pm":5102,"doi":5103},"14726513","W14726513","10548366","10.1023\u002Fa:1026647024077",{"id":26,"text":5105,"url":5106,"identifiers":5107},"Reddy, 2013, Role of probiotics in short bowel syndrome in infants and children–a systematic review, Nutrients, 5, 679, 10.3390\u002Fnu5030679","https:\u002F\u002Fdoi.org\u002F10.3390\u002Fnu5030679",{"mag":5108,"pmc":5109,"openalex":5110,"pm":5111,"doi":5112},"2090546766","3705313","W2090546766","23462584","10.3390\u002Fnu5030679",{"id":5114,"text":5115,"url":5116,"identifiers":5117},"f439229a-88ca-4b6c-8936-a9bf17c9b1ee","Kanamori, 2004, Experience of long-term synbiotic therapy in seven short bowel patients with refractory enterocolitis, J Pediatr Surg, 39, 1686, 10.1016\u002Fj.jpedsurg.2004.07.013","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0022346804004749",{"doi":5118},"10.1016\u002Fj.jpedsurg.2004.07.013",{"id":26,"text":5120,"url":5121,"identifiers":5122},"Sentongo, 2008, Intestinal permeability and effects of Lactobacillus rhamnosus therapy in children with short bowel syndrome, J Pediatr Gastroenterol Nutr, 46, 41, 10.1097\u002F01.mpg.0000304452.92175.f5","https:\u002F\u002Fdoi.org\u002F10.1097\u002F01.mpg.0000304452.92175.f5",{"mag":5123,"openalex":5124,"pm":5125,"doi":5126},"2085260006","W2085260006","18162832","10.1097\u002F01.mpg.0000304452.92175.f5",{"id":26,"text":5128,"url":5129,"identifiers":5130},"Gillard, 2017, Microbiota is involved in post-resection adaptation in humans with short bowel syndrome, Front Physiol, 8, 224, 10.3389\u002Ffphys.2017.00224","https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffphys.2017.00224",{"mag":5131,"pmc":5132,"openalex":5133,"pm":5134,"doi":5135},"2607503854","5395573","W2607503854","28469580","10.3389\u002Ffphys.2017.00224",{"id":26,"text":5137,"url":5138,"identifiers":5139},"Mowat, 2014, Regional specialization within the intestinal immune system, Nat Rev Immunol, 14, 667, 10.1038\u002Fnri3738","https:\u002F\u002Fdoi.org\u002F10.1038\u002Fnri3738",{"mag":5140,"openalex":5141,"pm":5142,"doi":5143},"2043659905","W2043659905","25234148","10.1038\u002Fnri3738",{"id":26,"text":5145,"url":5146,"identifiers":5147},"Round, 2009, The gut microbiome shapes intestinal immune responses during health and disease, Nat Rev Immunol, 9, 313, 10.1038\u002Fnri2515","http:\u002F\u002Fdx.doi.org\u002F10.1038\u002Fnri2515",{"doi":5148},"10.1038\u002Fnri2515",{"id":26,"text":5150,"url":5151,"identifiers":5152},"Gensollen, 2016, How colonization by microbiota in early life shapes the immune system, Science, 352, 539, 10.1126\u002Fscience.aad9378","https:\u002F\u002Fdoi.org\u002F10.1126\u002Fscience.aad9378",{"mag":5153,"pmc":5154,"openalex":5155,"pm":5156,"doi":5157},"2343758687","5050524","W2343758687","27126036","10.1126\u002Fscience.aad9378",{"id":26,"text":5159,"url":5160,"identifiers":5161},"Moreau, 1978, Increase in the population of duodenal immunoglobulin A plasmocytes in axenic mice associated with different living or dead bacterial strains of intestinal origin, Infect Immun, 21, 532, 10.1128\u002Fiai.21.2.532-539.1978","https:\u002F\u002Fdoi.org\u002F10.1128\u002Fiai.21.2.532-539.1978",{"mag":5162,"pmc":5163,"openalex":5164,"pm":5165,"doi":5166},"2157172492","422028","W2157172492","357289","10.1128\u002Fiai.21.2.532-539.1978",{"id":5168,"text":5169,"url":5170,"identifiers":5171},"3f985bde-d63b-4d82-89d5-4d44fd0ece93","Suzuki, 2002, Regional variations in the distributions of small intestinal intraepithelial lymphocytes in germ-free and specific pathogen-free mice, Exp Mol Pathol, 72, 230, 10.1006\u002Fexmp.2002.2433","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0014480002924330",{"doi":5172},"10.1006\u002Fexmp.2002.2433",{"id":26,"text":5174,"url":26,"identifiers":5175},"Tlaskalova-Hogenova, 1983, Development of immunological capacity under germfree and conventional conditions, Ann N Y Acad Sci, 409, 96, 10.1111\u002Fj.1749-6632.1983.tb26862.x",{"doi":5176},"10.1111\u002Fj.1749-6632.1983.tb26862.x",{"id":5178,"text":5179,"url":5180,"identifiers":5181},"aa3fe177-4499-4327-be2a-1e3db37ad822","Schall, 2017, Short bowel syndrome results in increased gene expression associated with proliferation, inflammation, bile acid synthesis and immune system activation: RNA sequencing a zebrafish SBS model, BMC Genomics, 18, 23, 10.1186\u002Fs12864-016-3433-4","https:\u002F\u002Fbmcgenomics.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs12864-016-3433-4",{"doi":5182},"10.1186\u002Fs12864-016-3433-4",{"id":26,"text":5184,"url":5185,"identifiers":5186},"Murakami, 2007, Changes in lymphocyte phenotypes and cytokine production by surgical stress in a rat small intestinal resection model, J Clin Biochem Nutr, 40, 216, 10.3164\u002Fjcbn.40.216","https:\u002F\u002Fdoi.org\u002F10.3164\u002Fjcbn.40.216",{"mag":5187,"pmc":5188,"openalex":5189,"pm":5190,"doi":5191},"2084955436","2275767","W2084955436","18398499","10.3164\u002Fjcbn.40.216",{"id":5193,"text":5194,"url":5195,"identifiers":5196},"d3c9576a-596e-4ff5-8e18-995a9abfdfa5","Barrena, 1995, Lymphocyte subpopulations after extensive small bowel resection in the rat, J Pediatr Surg, 30, 1447, 10.1016\u002F0022-3468(95)90403-4","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002F0022346895904034",{"doi":5197},"10.1016\u002F0022-3468(95)90403-4",{"id":5199,"text":5200,"url":5201,"identifiers":5202},"0e187ec9-c155-4484-899c-d211255fd723","Hise, 2006, Inflammatory mediators and immune function are altered in home parenteral nutrition patients, Nutrition, 22, 97, 10.1016\u002Fj.nut.2005.05.011","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0899900705002807",{"doi":5203},"10.1016\u002Fj.nut.2005.05.011",{"id":26,"text":5205,"url":5206,"identifiers":5207},"Turato, 2016, The impact of intestinal resection on the immune function of short bowel syndrome patients, Hum Immunol, 77, 1202, 10.1016\u002Fj.humimm.2016.07.237","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.humimm.2016.07.237",{"mag":5208,"openalex":5209,"pm":5210,"doi":5211},"2477013041","W2477013041","27486135","10.1016\u002Fj.humimm.2016.07.237",{"id":26,"text":5213,"url":5214,"identifiers":5215},"Schmidt, 1996, Effect of intestinal resection on human small bowel motility, Gut, 38, 859, 10.1136\u002Fgut.38.6.859","https:\u002F\u002Fdoi.org\u002F10.1136\u002Fgut.38.6.859",{"mag":5216,"pmc":5217,"openalex":5218,"pm":5219,"doi":5220},"2015431634","1383193","W2015431634","8984024","10.1136\u002Fgut.38.6.859",{"id":26,"text":5222,"url":5223,"identifiers":5224},"Gianino, 2003, GDNF availability determines enteric neuron number by controlling precursor proliferation, Development, 130, 2187, 10.1242\u002Fdev.00433","https:\u002F\u002Fdoi.org\u002F10.1242\u002Fdev.00433",{"mag":5225,"openalex":5226,"pm":5227,"doi":5228},"2122295014","W2122295014","12668632","10.1242\u002Fdev.00433",{"id":26,"text":5230,"url":5231,"identifiers":5232},"Hitch, 2012, Ret heterozygous mice have enhanced intestinal adaptation after massive small bowel resection, Am J Physiol Gastrointest Liver Physiol, 302, G1143, 10.1152\u002Fajpgi.00296.2011","https:\u002F\u002Fdoi.org\u002F10.1152\u002Fajpgi.00296.2011",{"mag":5233,"pmc":5234,"openalex":5235,"pm":5236,"doi":5237},"1969173012","3362098","W1969173012","22421622","10.1152\u002Fajpgi.00296.2011",{"id":26,"text":5239,"url":5240,"identifiers":5241},"Lai, 2017, Effects of exogenous glucagon-like peptide-2 and distal bowel resection on intestinal and systemic adaptive responses in rats, PLoS One, 12, e0181453, 10.1371\u002Fjournal.pone.0181453","https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.pone.0181453",{"mag":5242,"pmc":5243,"openalex":5244,"pm":5245,"doi":5246},"2737618331","5524396","W2737618331","28738080","10.1371\u002Fjournal.pone.0181453",{"id":26,"text":5248,"url":5249,"identifiers":5250},"Anitha, 2012, Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling, Gastroenterology, 143, 1006, 10.1053\u002Fj.gastro.2012.06.034","https:\u002F\u002Fdoi.org\u002F10.1053\u002Fj.gastro.2012.06.034",{"mag":5251,"pmc":5252,"openalex":5253,"pm":5254,"doi":5255},"2155134319","3458182","W2155134319","22732731","10.1053\u002Fj.gastro.2012.06.034",{"id":5257,"text":5258,"url":5259,"identifiers":5260},"26bc16ed-6e2a-4fe8-95bb-6a2e2552dc82","Muller, 2014, Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility, Cell, 158, 300, 10.1016\u002Fj.cell.2014.04.050","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0092867414007351",{"doi":5261},"10.1016\u002Fj.cell.2014.04.050",{"id":5263,"text":5264,"url":5265,"identifiers":5266},"726b7fa1-d8cf-49cf-98c7-0c720da85923","Gabanyi, 2016, Neuro-immune interactions drive tissue programming in intestinal macrophages, Cell, 164, 378, 10.1016\u002Fj.cell.2015.12.023","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0092867415016876",{"doi":5267},"10.1016\u002Fj.cell.2015.12.023",{"id":26,"text":5269,"url":5270,"identifiers":5271},"Gaboriau-Routhiau, 2009, The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses, Immunity, 31, 677, 10.1016\u002Fj.immuni.2009.08.020","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.immuni.2009.08.020",{"mag":5272,"openalex":5273,"pm":5274,"doi":5275},"2167519234","W2167519234","19833089","10.1016\u002Fj.immuni.2009.08.020",{"id":5277,"text":1347,"url":5278,"identifiers":5279},"0bf3cdff-1863-4486-96e1-67407018299f","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0092867409012483",{"doi":1349},{"id":26,"text":5281,"url":5282,"identifiers":5283},"Alam, 2016, The microenvironment of injured murine gut elicits a local pro-restitutive microbiota, Nat Microbiol, 1, 15021, 10.1038\u002Fnmicrobiol.2015.21","https:\u002F\u002Fdoi.org\u002F10.1038\u002Fnmicrobiol.2015.21",{"mag":5284,"pmc":5285,"openalex":5286,"pm":5287,"doi":5288},"2529915577","5076466","W2529915577","27571978","10.1038\u002Fnmicrobiol.2015.21",{"id":26,"text":5290,"url":5291,"identifiers":5292},"Sukhotnik, 2016, Effect of bowel resection on TLR signaling during intestinal adaptation in a rat model, Surg Endosc, 30, 4416, 10.1007\u002Fs00464-016-4760-x","https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00464-016-4760-x",{"mag":5293,"openalex":5294,"pm":5295,"doi":5296},"2285989618","W2285989618","26895894","10.1007\u002Fs00464-016-4760-x",{"id":26,"text":5298,"url":5299,"identifiers":5300},"Bry, 1996, A model of host-microbial interactions in an open mammalian ecosystem, Science, 273, 1380, 10.1126\u002Fscience.273.5280.1380","https:\u002F\u002Fdoi.org\u002F10.1126\u002Fscience.273.5280.1380",{"mag":5301,"openalex":5302,"pm":5303,"doi":5304},"2050016905","W2050016905","8703071","10.1126\u002Fscience.273.5280.1380",{"id":5306,"text":5307,"url":5308,"identifiers":5309},"fdb37abf-9d5e-4635-afdc-5d0eb7314cfa","Comstock, 2006, Bacterial glycans: key mediators of diverse host immune responses, Cell, 126, 847, 10.1016\u002Fj.cell.2006.08.021","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0092867406010889",{"doi":5310},"10.1016\u002Fj.cell.2006.08.021",{"id":26,"text":5312,"url":5313,"identifiers":5314},"Zheng, 2011, The footprints of gut microbial-mammalian co-metabolism, J Proteome Res, 10, 5512, 10.1021\u002Fpr2007945","https:\u002F\u002Fdoi.org\u002F10.1021\u002Fpr2007945",{"mag":5315,"openalex":5316,"pm":5317,"doi":5318},"1978337734","W1978337734","21970572","10.1021\u002Fpr2007945",{"id":26,"text":5320,"url":26,"identifiers":5321},"Koruda, 1986, Harry M. Vars award. The effect of a pectin-supplemented elemental diet on intestinal adaptation to massive small bowel resection, JPEN J Parenter Enteral Nutr, 10, 343, 10.1177\u002F0148607186010004343",{"doi":5322},"10.1177\u002F0148607186010004343",{"id":5324,"text":5325,"url":5326,"identifiers":5327},"90a354b2-6095-48b3-b8d3-401dd2a9e3a9","Tappenden, 1997, Short-chain fatty acid-supplemented total parenteral nutrition enhances functional adaptation to intestinal resection in rats, Gastroenterology, 112, 792, 10.1053\u002Fgast.1997.v112.pm9041241","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0016508597001182",{"doi":5328},"10.1053\u002Fgast.1997.v112.pm9041241",{"id":26,"text":5330,"url":5331,"identifiers":5332},"Koruda, 1988, Effect of parenteral nutrition supplemented with short-chain fatty acids on adaptation to massive small bowel resection, Gastroenterology, 95, 715, 10.1016\u002FS0016-5085(88)80019-2","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fs0016-5085(88)80019-2",{"mag":5333,"openalex":5334,"pm":5335,"doi":5336},"1720270979","W1720270979","2456244","10.1016\u002Fs0016-5085(88)80019-2",{"id":26,"text":5338,"url":5339,"identifiers":5340},"Tappenden, 1998, Short-chain fatty acid-supplemented total parenteral nutrition alters intestinal structure, glucose transporter 2 (GLUT2) mRNA and protein, and proglucagon mRNA abundance in normal rats, Am J Clin Nutr, 68, 118, 10.1093\u002Fajcn\u002F68.1.118","https:\u002F\u002Fdoi.org\u002F10.1093\u002Fajcn\u002F68.1.118",{"mag":5341,"openalex":5342,"pm":5343,"doi":5344},"1932348039","W1932348039","9665105","10.1093\u002Fajcn\u002F68.1.118",{"id":26,"text":5346,"url":5347,"identifiers":5348},"Tappenden, 2010, Emerging therapies for intestinal failure, Arch Surg, 145, 528, 10.1001\u002Farchsurg.2010.102","https:\u002F\u002Fdoi.org\u002F10.1001\u002Farchsurg.2010.102",{"mag":5349,"openalex":5350,"pm":5351,"doi":5352},"2131128765","W2131128765","20566971","10.1001\u002Farchsurg.2010.102",{"id":26,"text":5354,"url":5355,"identifiers":5356},"Bartholome, 2004, Supplementation of total parenteral nutrition with butyrate acutely increases structural aspects of intestinal adaptation after an 80% jejunoileal resection in neonatal piglets, JPEN J Parenter Enteral Nutr, 28, 210, 10.1177\u002F0148607104028004210","https:\u002F\u002Fdoi.org\u002F10.1177\u002F0148607104028004210",{"mag":5357,"openalex":5358,"pm":5359,"doi":5360},"1982696037","W1982696037","15291402","10.1177\u002F0148607104028004210",{"id":26,"text":5362,"url":5363,"identifiers":5364},"Gosselin, 2014, Enteral nutrition in the management of pediatric intestinal failure, J Pediatr, 165, 1085, 10.1016\u002Fj.jpeds.2014.08.012","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jpeds.2014.08.012",{"mag":5365,"pmc":5366,"openalex":5367,"pm":5368,"doi":5369},"2061540164","4253063","W2061540164","25242686","10.1016\u002Fj.jpeds.2014.08.012",{"id":26,"text":5371,"url":26,"identifiers":5372},"Atia, 2011, JPEN J Parenter Enteral Nutr, 35, 229, 10.1177\u002F0148607110378410",{"doi":5373},"10.1177\u002F0148607110378410",{"id":5375,"text":5376,"url":5377,"identifiers":5378},"26a54469-b41a-487b-b783-149a5f5742e5","Vieira, 2012, Oral administration of sodium butyrate attenuates inflammation and mucosal lesion in experimental acute ulcerative colitis, J Nutr Biochem, 23, 430, 10.1016\u002Fj.jnutbio.2011.01.007","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0955286311000611",{"doi":5379},"10.1016\u002Fj.jnutbio.2011.01.007",{"id":26,"text":5381,"url":5382,"identifiers":5383},"Butzner, 1996, Butyrate enema therapy stimulates mucosal repair in experimental colitis in the rat, Gut, 38, 568, 10.1136\u002Fgut.38.4.568","https:\u002F\u002Fdoi.org\u002F10.1136\u002Fgut.38.4.568",{"mag":5384,"pmc":5385,"openalex":5386,"pm":5387,"doi":5388},"2048125796","1383116","W2048125796","8707089","10.1136\u002Fgut.38.4.568",{"id":26,"text":5390,"url":5391,"identifiers":5392},"Singh, 2014, Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis, Immunity, 40, 128, 10.1016\u002Fj.immuni.2013.12.007","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.immuni.2013.12.007",{"mag":5393,"pmc":5394,"openalex":5395,"pm":5396,"doi":5397},"1981266729","4305274","W1981266729","24412617","10.1016\u002Fj.immuni.2013.12.007",{"id":26,"text":5399,"url":5400,"identifiers":5401},"Chang, 2014, The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition, Proc Natl Acad Sci U S A, 111, 2247, 10.1073\u002Fpnas.1322269111","https:\u002F\u002Fdoi.org\u002F10.1073\u002Fpnas.1322269111",{"mag":5402,"pmc":5403,"openalex":5404,"pm":5405,"doi":5406},"2002703043","3926023","W2002703043","24390544","10.1073\u002Fpnas.1322269111",{"id":4123,"text":5408,"url":4125,"identifiers":5409},"Cao, 2017, Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine, Sci Rep, 7, 10322, 10.1038\u002Fs41598-017-10835-8",{"doi":4127},{"id":26,"text":5411,"url":5412,"identifiers":5413},"Reigstad, 2015, Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells, FASEB J, 29, 1395, 10.1096\u002Ffj.14-259598","https:\u002F\u002Fdoi.org\u002F10.1096\u002Ffj.14-259598",{"mag":5414,"pmc":5415,"openalex":5416,"pm":5417,"doi":5418},"1997608252","4396604","W1997608252","25550456","10.1096\u002Ffj.14-259598",{"id":5420,"text":1155,"url":5421,"identifiers":5422},"52336e35-faea-4e7b-9915-4903320d05ca","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0092867415002482",{"doi":1157},{"id":26,"text":5424,"url":5425,"identifiers":5426},"Soret, 2010, Short-chain fatty acids regulate the enteric neurons and control gastrointestinal motility in rats, Gastroenterology, 138, 1772, 10.1053\u002Fj.gastro.2010.01.053","https:\u002F\u002Fdoi.org\u002F10.1053\u002Fj.gastro.2010.01.053",{"mag":5427,"openalex":5428,"pm":5429,"doi":5430},"2012800693","W2012800693","20152836","10.1053\u002Fj.gastro.2010.01.053",{"id":26,"text":5432,"url":5433,"identifiers":5434},"Atarashi, 2008, ATP drives lamina propria T(H)17 cell differentiation, Nature, 455, 808, 10.1038\u002Fnature07240","http:\u002F\u002Fdx.doi.org\u002F10.1038\u002Fnature07240",{"doi":5435},"10.1038\u002Fnature07240",{"id":26,"text":5437,"url":26,"identifiers":5438},"Beulens, 2013, The role of menaquinones (vitamin K2) in human health, Br J Nutr, 110, 1357, 10.1017\u002FS0007114513001013",{"doi":5439},"10.1017\u002FS0007114513001013",{"id":5441,"text":5442,"url":5443,"identifiers":5444},"07f1885b-5f7c-463b-917d-ffc655605ffb","Cella, 2015, Aryl hydrocarbon receptor: Linking environment to immunity, Semin Immunol, 27, 310, 10.1016\u002Fj.smim.2015.10.002","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS1044532315000664",{"doi":5445},"10.1016\u002Fj.smim.2015.10.002",{"id":5447,"text":5448,"url":5449,"identifiers":5450},"3d051cf4-2e22-4bcb-b773-c6113f8b7b96","Pols, 2011, The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation, J Hepatol, 54, 1263, 10.1016\u002Fj.jhep.2010.12.004","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0168827810011062",{"doi":5451},"10.1016\u002Fj.jhep.2010.12.004",{"id":5453,"text":5454,"url":5455,"identifiers":5456},"f4762fa0-ec81-4645-8cd0-27d0aedd1d66","Alemi, 2013, The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice, Gastroenterology, 144, 145, 10.1053\u002Fj.gastro.2012.09.055","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0016508512014564",{"doi":5457},"10.1053\u002Fj.gastro.2012.09.055",{"id":5459,"createTime":5460,"updateTime":5461,"relativeEntities":5462,"slug":5463,"properties":5464,"entityType":761,"verifyStatus":25,"verifyTime":5473,"verifyNote":763,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36,"primaryUrl":5474,"fullTextUrl":26,"authors":5475,"publicationType":845,"publisherRelationship":5503,"citationCount":36,"citationInfo":5530,"publishDate":5532,"publishYear":1750,"citationAnalyzeStatus":5533,"lastCitationAnalyze":5534,"indexDatabases":26,"openAccess":26,"references":26,"isForceReanalyzing":1654},"9852369d-88d2-4145-8116-69041b1615c2","2024-02-02T04:47:17.270+00:00","2026-05-17T00:48:33.300+00:00",[],"Role-of-Hypoxia-Inducible-Factors-in-the-Development-of-Liver-Fibrosis",{"references":5465,"title":5467,"doi":5469,"gsPaper":5471},{"VOID":5466},"Friedman, 1985, Hepatic lipocytes: the principal collagen-producing cells of normal rat liver, Proc Natl Acad Sci USA, 82, 8681, 10.1073\u002Fpnas.82.24.8681\nFriedman, 2008, Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver, Physiol Rev, 88, 125, 10.1152\u002Fphysrev.00013.2007\nKinnman, 2003, The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver fibrogenesis, Lab Invest, 83, 163, 10.1097\u002F01.LAB.0000054178.01162.E4\nWells, 2004, Autocrine release of TGF-beta by portal fibroblasts regulates cell growth, FEBS Lett, 559, 107, 10.1016\u002FS0014-5793(04)00037-7\nMoon, 2009, Reduced liver fibrosis in hypoxia-inducible factor-1α-deficient mice, Am J Physiol Gastrointest Liver Physiol, 296, G582, 10.1152\u002Fajpgi.90368.2008\nWang, 1995, Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension, Proc Natl Acad Sci USA, 92, 5510, 10.1073\u002Fpnas.92.12.5510\nJiang, 1996, Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1, J Biol Chem, 271, 17771, 10.1074\u002Fjbc.271.30.17771\nSemenza, 1992, A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation, Mol Cell Biol, 12, 5447, 10.1128\u002FMCB.12.12.5447\nEma, 1997, A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development, Proc Natl Acad Sci USA, 94, 4273, 10.1073\u002Fpnas.94.9.4273\nGu, 1998, Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3α, Gene Expr, 7, 205\nHuang, 1998, Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway, Proc Natl Acad Sci USA, 95, 7987, 10.1073\u002Fpnas.95.14.7987\nJi, 1982, Periportal and pericentral pyridine nucleotide fluorescence from the surface of the perfused liver: evaluation of the hypothesis that chronic treatment with ethanol produces pericentral hypoxia, Proc Natl Acad Sci USA, 79, 5415, 10.1073\u002Fpnas.79.17.5415\nLi, 2004, Liver hypoxia and lack of recovery after reperfusion at high blood alcohol levels in the intragastric feeding model of alcohol liver disease, Exp Mol Pathol, 77, 184, 10.1016\u002Fj.yexmp.2004.08.002\nCopple, 2004, Modes of cell death in rat liver after monocrotaline exposure, Toxicol Sci, 77, 172, 10.1093\u002Ftoxsci\u002Fkfh011\nChaudhuri, 2011, Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia, Toxicol Appl Pharmacol, 252, 211, 10.1016\u002Fj.taap.2011.02.005\nCopple, 2006, Anticoagulation and inhibition of nitric oxide synthase influence hepatic hypoxia after monocrotaline exposure, Toxicology, 225, 128, 10.1016\u002Fj.tox.2006.05.016\nArteel, 1998, Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state, Eur J Biochem, 253, 743, 10.1046\u002Fj.1432-1327.1998.2530743.x\nJames, 2006, Induction of the nuclear factor HIF-1α in acetaminophen toxicity: evidence for oxidative stress, Biochem Biophys Res Commun, 343, 171, 10.1016\u002Fj.bbrc.2006.02.143\nSparkenbaugh, 2011, The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity, J Pharmacol Exp Ther, 338, 492, 10.1124\u002Fjpet.111.180521\nMochizuki, 2014, Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-dependent manner by modulating macrophage phenotype in mice, J Immunol, 192, 3847, 10.4049\u002Fjimmunol.1303195\nRosmorduc, 1999, Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis, Am J Pathol, 155, 1065, 10.1016\u002FS0002-9440(10)65209-1\nCorpechot, 2002, Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis, Hepatology, 35, 1010, 10.1053\u002Fjhep.2002.32524\nCopple, 2012, Hypoxia-inducible factor activation in myeloid cells contributes to the development of liver fibrosis in cholestatic mice, J Pharmacol Exp Ther, 341, 307, 10.1124\u002Fjpet.111.189340\nYoshida, 2006, Hypoxia inducible factor 1-alpha regulates of platelet derived growth factor-B in human glioblastoma cells, J Neurooncol, 76, 13, 10.1007\u002Fs11060-005-3279-0\nCalvani, 2006, Hypoxic induction of an HIF-1α-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells, Blood, 107, 2705, 10.1182\u002Fblood-2005-09-3541\nForsythe, 1996, Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1, Mol Cell Biol, 16, 4604, 10.1128\u002FMCB.16.9.4604\nKietzmann, 1999, Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes, Blood, 94, 4177, 10.1182\u002Fblood.V94.12.4177\nIyer, 1998, Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha, Genes Dev, 12, 149, 10.1101\u002Fgad.12.2.149\nKuhn, 1995, Inducible gene targeting in mice, Science, 269, 1427, 10.1126\u002Fscience.7660125\nNeef, 2006, Oral imatinib treatment reduces early fibrogenesis but does not prevent progression in the long term, J Hepatol, 44, 167, 10.1016\u002Fj.jhep.2005.06.015\nFriedman, 1989, Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors, J Clin Invest, 84, 1780, 10.1172\u002FJCI114362\nBergheim, 2006, Critical role of plasminogen activator inhibitor-1 in cholestatic liver injury and fibrosis, J Pharmacol Exp Ther, 316, 592, 10.1124\u002Fjpet.105.095042\nYu, 2003, Role of fibroblast growth factor type 1 and 2 in carbon tetrachloride-induced hepatic injury and fibrogenesis, Am J Pathol, 163, 1653, 10.1016\u002FS0002-9440(10)63522-5\nCopple, 2009, Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic hepatocytes, Liver Int, 29, 1010, 10.1111\u002Fj.1478-3231.2009.02015.x\nCopple, 2010, Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms, Liver Int, 30, 669, 10.1111\u002Fj.1478-3231.2010.02205.x\nYoung, 2004, Molecular interactions that confer latency to transforming growth factor-beta, J Biol Chem, 279, 38032, 10.1074\u002Fjbc.M405658200\nD’Angelo, 2001, Authentic matrix vesicles contain active metalloproteases (MMP). a role for matrix vesicle-associated MMP-13 in activation of transforming growth factor-beta, J Biol Chem, 276, 11347, 10.1074\u002Fjbc.M009725200\nMaeda, 2001, Activation of latent transforming growth factor beta1 by stromelysin 1 in extracts of growth plate chondrocyte-derived matrix vesicles, J Bone Miner Res, 16, 1281, 10.1359\u002Fjbmr.2001.16.7.1281\nScott, 2015, Hepatocyte-specific deletion of ARNT (aryl hydrocarbon receptor nuclear translocator) results in altered fibrotic gene expression in the thioacetamide model of liver injury, PLoS One, 10, e0121650, 10.1371\u002Fjournal.pone.0121650\nRoychowdhury, 2014, Moderate, chronic ethanol feeding exacerbates carbon-tetrachloride-induced hepatic fibrosis via hepatocyte-specific hypoxia inducible factor 1α, Pharmacol Res Perspect, 2, e00061, 10.1002\u002Fprp2.61\nQu, 2011, Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis, Hepatology, 54, 472, 10.1002\u002Fhep.24400\nHaase, 2001, Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor, Proc Natl Acad Sci USA, 98, 1583, 10.1073\u002Fpnas.98.4.1583\nRivera, 2001, Attenuation of CCl4-induced hepatic fibrosis by GdCl3 treatment or dietary glycine, Am J Physiol Gastrointest Liver Physiol, 281, G200, 10.1152\u002Fajpgi.2001.281.1.G200\nJaeschke, 1991, Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver, Am J Physiol, 260, G355\nDuffield, 2005, Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair, J Clin Invest, 115, 56, 10.1172\u002FJCI200522675\nKarlmark, 2009, Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis, Hepatology, 50, 261, 10.1002\u002Fhep.22950\nFaiz Kabir Uddin Ahmed, 2000, In situ expression of fibrogenic growth factors and their receptors in biliary atresia: comparison between early and late stages, J Pathol, 192, 73, 10.1002\u002F1096-9896(2000)9999:9999\u003C::AID-PATH657>3.0.CO;2-J\nNakatsukasa, 1990, Cellular distribution of transforming growth factor-beta 1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis, J Clin Invest, 85, 1833, 10.1172\u002FJCI114643\nCopple BL, Bai S, Moon JO. Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic Kupffer cells. Hepatol Res;40:530–539.\nTakeda N, O’Dea EL, Doedens A, et al. Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes Dev;24:491–501.\nBrenner, 2012, Origin of myofibroblasts in liver fibrosis, Fibrogenesis Tissue Repair, 5, S17, 10.1186\u002F1755-1536-5-S1-S17\nShi, 2007, Hypoxia induces the activation of human hepatic stellate cells LX-2 through TGF-beta signaling pathway, FEBS Lett, 581, 203, 10.1016\u002Fj.febslet.2006.12.010\nCopple, 2011, Hypoxia-inducible factor-1α regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis, Liver Int, 31, 230, 10.1111\u002Fj.1478-3231.2010.02347.x\nNovo, 2007, Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells, Am J Pathol, 170, 1942, 10.2353\u002Fajpath.2007.060887\nYoshiji, 2003, Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis, Gut, 52, 1347, 10.1136\u002Fgut.52.9.1347\nYang, 2014, Vascular endothelial growth factor promotes fibrosis resolution and repair in mice, Gastroenterology, 146, 1339, 10.1053\u002Fj.gastro.2014.01.061\nKantari-Mimoun, 2015, Resolution of liver fibrosis requires myeloid cell-driven sinusoidal angiogenesis, Hepatology, 61, 2042, 10.1002\u002Fhep.27635\nSeki, 2009, CCR1 and CCR5 promote hepatic fibrosis in mice, J Clin Invest, 119, 1858\nWeng, 2009, The etiology of liver damage imparts cytokines transforming growth factor beta1 or interleukin-13 as driving forces in fibrogenesis, Hepatology, 50, 230, 10.1002\u002Fhep.22934\nFallon, 2000, Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent, J Immunol, 164, 2585, 10.4049\u002Fjimmunol.164.5.2585\nOben, 2003, Norepinephrine and neuropeptide Y promote proliferation and collagen gene expression of hepatic myofibroblastic stellate cells, Biochem Biophys Res Commun, 302, 685, 10.1016\u002FS0006-291X(03)00232-8\nWebby, 2009, Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing, Science, 325, 90, 10.1126\u002Fscience.1175865\nYamane, 2006, JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor, Cell, 125, 483, 10.1016\u002Fj.cell.2006.03.027\nZhong, 2001, Regulator of G protein signaling proteins: novel multifunctional drug targets, J Pharmacol Exp Ther, 297, 837\nSkrtic, 1997, Insulin-like growth factors stimulate expression of hepatocyte growth factor but not transforming growth factor beta1 in cultured hepatic stellate cells, Endocrinology, 138, 4683, 10.1210\u002Fendo.138.11.5540\nSkrtic, 1999, Hepatocyte-stimulated expression of hepatocyte growth factor (HGF) in cultured rat hepatic stellate cells, J Hepatol, 30, 115, 10.1016\u002FS0168-8278(99)80015-4\nNejak-Bowen, 2013, Conditional genetic elimination of hepatocyte growth factor in mice compromises liver regeneration after partial hepatectomy, PLoS One, 8, e59836, 10.1371\u002Fjournal.pone.0059836\nCorpechot, 2002, Hepatocyte growth factor and c-Met inhibition by hepatic cell hypoxia: a potential mechanism for liver regeneration failure in experimental cirrhosis, Am J Pathol, 160, 613, 10.1016\u002FS0002-9440(10)64881-X\nGardner, 1999, Absence of integrin α1β1 in the mouse causes loss of feedback regulation of collagen synthesis in normal and wounded dermis, J Cell Sci, 112, 263, 10.1242\u002Fjcs.112.3.263\nBezerra, 1999, Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver, Proc Natl Acad Sci USA, 96, 15143, 10.1073\u002Fpnas.96.26.15143\nPohl, 2001, Plasminogen deficiency leads to impaired lobular reorganization and matrix accumulation after chronic liver injury, Am J Pathol, 159, 2179, 10.1016\u002FS0002-9440(10)63069-6\nCurrier, 2003, Plasminogen directs the pleiotropic effects of uPA in liver injury and repair, Am J Physiol Gastrointest Liver Physiol, 284, G508, 10.1152\u002Fajpgi.00336.2002\nGaudio, 2006, Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism, Gastroenterology, 130, 1270, 10.1053\u002Fj.gastro.2005.12.034\nZhang, 2015, Hypoxia-inducible factor-2α limits natural killer T cell cytotoxicity in renal ischemia\u002Freperfusion injury, J Am Soc Nephrol\nLukashev, 2006, Cutting edge: hypoxia-inducible factor 1α and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes, J Immunol, 177, 4962, 10.4049\u002Fjimmunol.177.8.4962\nMakino, 2003, Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells, J Immunol, 171, 6534, 10.4049\u002Fjimmunol.171.12.6534\nKojima, 2002, Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α -deficient chimeric mice, Proc Natl Acad Sci USA, 99, 2170, 10.1073\u002Fpnas.052706699\nRankin, 2008, Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice, Oncogene, 27, 5354, 10.1038\u002Fonc.2008.160\nQu, 2015, Transarterial chemoembolization aggravated peritumoral fibrosis via hypoxia-inducible factor-1α dependent pathway in hepatocellular carcinoma, J Gastroenterol Hepatol, 30, 925, 10.1111\u002Fjgh.12873",{"EN":5468},"Role of Hypoxia-Inducible Factors in the Development 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2009, Inflammatory bowel disease, N Engl J Med, 361, 2066, 10.1056\u002FNEJMra0804647\nGunther, 2013, Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium, Gut, 62, 1062, 10.1136\u002Fgutjnl-2011-301364\nKhor, 2011, Genetics and pathogenesis of inflammatory bowel disease, Nature, 474, 307, 10.1038\u002Fnature10209\nOkamoto, 2016, Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease, J Gastroenterol, 51, 11, 10.1007\u002Fs00535-015-1098-4\nNeurath, 2012, Mucosal healing in inflammatory bowel diseases: a systematic review, Gut, 61, 1619, 10.1136\u002Fgutjnl-2012-302830\nVereecke, 2009, The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology, Trends Immunol, 30, 383, 10.1016\u002Fj.it.2009.05.007\nKaser, 2010, Inflammatory bowel disease, Ann Rev Immunol, 28, 573, 10.1146\u002Fannurev-immunol-030409-101225\nZeissig, 2004, Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment, Gut, 53, 1295, 10.1136\u002Fgut.2003.036632\nLin, 2003, NF-kappaB in cancer: a marked target, Semin Cancer Biol, 13, 107, 10.1016\u002FS1044-579X(02)00128-1\nEgan, 2004, IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium, Proc Natl Acad Sci U S A, 101, 2452, 10.1073\u002Fpnas.0306734101\nChen, 2003, The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion, Nat Med, 9, 575, 10.1038\u002Fnm849\nNenci, 2007, Epithelial NEMO links innate immunity to chronic intestinal inflammation, Nature, 446, 557, 10.1038\u002Fnature05698\nGarcia-Carbonell, 2018, Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death, Proc Natl Acad Sci U S A, 115, E9192, 10.1073\u002Fpnas.1810584115\nGuma, 2011, Constitutive intestinal NF-kappaB does not trigger destructive inflammation unless accompanied by MAPK activation, J Exp Med, 208, 1889, 10.1084\u002Fjem.20110242\nPasparakis, 2015, Necroptosis and its role in inflammation, Nature, 517, 311, 10.1038\u002Fnature14191\nWeinlich, 2014, The two faces of receptor interacting protein kinase-1, Mol Cell, 56, 469, 10.1016\u002Fj.molcel.2014.11.001\nWang, 2008, TNF-alpha induces two distinct caspase-8 activation pathways, Cell, 133, 693, 10.1016\u002Fj.cell.2008.03.036\nKanayama, 2004, TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains, Mol Cell, 15, 535, 10.1016\u002Fj.molcel.2004.08.008\nMicheau, 2002, The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex, J Biol Chem, 277, 45162, 10.1074\u002Fjbc.M206882200\nFeng, 2007, A novel inhibitory mechanism of mitochondrion-dependent apoptosis by a herpesviral protein, PLoS Pathog, 3, e174, 10.1371\u002Fjournal.ppat.0030174\nO'Donnell, 2011, Caspase 8 inhibits programmed necrosis by processing CYLD, Nat Cell Biol, 13, 1437, 10.1038\u002Fncb2362\nRogler, 1998, Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa, Gastroenterology, 115, 357, 10.1016\u002FS0016-5085(98)70202-1\nLeal, 2015, Identification of inflammatory mediators in patients with Crohn's disease unresponsive to anti-TNFalpha therapy, Gut, 64, 233, 10.1136\u002Fgutjnl-2013-306518\nSato, 2009, Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche, Nature, 459, 262, 10.1038\u002Fnature07935\nKreuz, 2001, NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling, Mol Cell Biol, 21, 3964, 10.1128\u002FMCB.21.12.3964-3973.2001\nKawakami, 2005, Transcriptional activation of survivin through the NF-kappaB pathway by human T-cell leukemia virus type I tax, Int J Cancer, 115, 967, 10.1002\u002Fijc.20954\nOfengeim, 2013, Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death, Nat Rev Cell Biol, 14, 727, 10.1038\u002Fnrm3683\nDegterev, 2008, Identification of RIP1 kinase as a specific cellular target of necrostatins, Nat Chem Biol, 4, 313, 10.1038\u002Fnchembio.83\nTakahashi, 2012, Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models, Cell Death Dis, 3, e437, 10.1038\u002Fcddis.2012.176\nMandal, 2014, RIP3 induces apoptosis independent of pronecrotic kinase activity, Mol Cell, 56, 481, 10.1016\u002Fj.molcel.2014.10.021\nBerger, 2015, Characterization of GSK’963: a structurally distinct, potent and selective inhibitor of RIP1 kinase, Cell Death Discov, 1, 10.1038\u002Fcddiscovery.2015.9\nPolykratis, 2014, Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo, J Immunol, 193, 1539, 10.4049\u002Fjimmunol.1400590\nNewton, 2004, Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4, Mol Cell Biol, 24, 1464, 10.1128\u002FMCB.24.4.1464-1469.2004\nZhang, 2009, RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis, Science, 325, 332, 10.1126\u002Fscience.1172308\nVandenabeele, 2010, The role of the kinases RIP1 and RIP3 in TNF-induced necrosis, Sci Signal, 3, re4, 10.1126\u002Fscisignal.3115re4\nVanden Berghe, 2014, Regulated necrosis: the expanding network of non-apoptotic cell death pathways, Nat Rev Mol Cell Biol, 15, 135, 10.1038\u002Fnrm3737\nKim, 2007, TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death, Mol Cell, 26, 675, 10.1016\u002Fj.molcel.2007.04.021\nShindo, 2013, Critical contribution of oxidative stress to TNFalpha-induced necroptosis downstream of RIPK1 activation, Biochem Biophys Res Commun, 436, 212, 10.1016\u002Fj.bbrc.2013.05.075\nZhang, 2017, RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome, Nat Commun, 8, 14329, 10.1038\u002Fncomms14329\nMatsuzawa-Ishimoto, 2017, Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium, J Exp Med, 214, 3687, 10.1084\u002Fjem.20170558\nPott, 2018, Intestinal epithelial cell autophagy is required to protect against TNF-induced apoptosis during chronic colitis in mice, Cell Host Microbe, 23, 191, 10.1016\u002Fj.chom.2017.12.017\nAden, 2018, ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING, J Exp Med, 215, 2868, 10.1084\u002Fjem.20171029\nAnderson, 2011, Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47, Nat Genet, 43, 246, 10.1038\u002Fng.764\nFranke, 2010, Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci, Nat Genet, 42, 1118, 10.1038\u002Fng.717\nLiu, 2015, Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations, Nat Genet, 47, 979, 10.1038\u002Fng.3359\nGreten, 2004, IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer, Cell, 118, 285, 10.1016\u002Fj.cell.2004.07.013\nPereira, 2015, Oxidative stress and DNA damage: implications in inflammatory bowel disease, Inflamm Bowel Dis, 21, 2403\nShaked, 2012, Chronic epithelial NF-kappaB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation, Proc Natl Acad Sci U S A, 109, 14007, 10.1073\u002Fpnas.1211509109\nLakatos, 2008, Risk for colorectal cancer in ulcerative colitis: changes, causes and management strategies, World J Gastroenterol, 14, 3937, 10.3748\u002Fwjg.14.3937\nAbraham, 2016, Cancer surveillance in ulcerative colitis and Crohn's disease: new strategies, Curr Opin Gastroenterol, 32, 32, 10.1097\u002FMOG.0000000000000234\nBrain, 2010, NOD2-mediated autophagy and Crohn disease, Autophagy, 6, 412, 10.4161\u002Fauto.6.3.11389\nNewton, 2014, Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis, Science, 343, 1357, 10.1126\u002Fscience.1249361\nRott, 1991, Tuberous sclerosis in two sibs of normal parents, Clin Genet, 39, 306, 10.1111\u002Fj.1399-0004.1991.tb03031.x\nDobin, 2013, STAR: ultrafast universal RNA-seq aligner, Bioinformatics, 29, 15, 10.1093\u002Fbioinformatics\u002Fbts635\nLi, 2011, RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome, BMC Bioinformatics, 12, 323, 10.1186\u002F1471-2105-12-323\nAnders, 2010, Differential expression analysis for sequence count data, Genome Biol, 11, R106, 10.1186\u002Fgb-2010-11-10-r106\nDelhase, 1999, Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation, Science, 284, 309, 10.1126\u002Fscience.284.5412.309\nWertz, 2004, De-ubiquitination and ubiquitin ligase domains of A20 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