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Physiol., 126, 379, 10.1085\u002Fjgp.200509355\nEvans, 2006, Transformation and microinjection, WormBook, 10.1895\u002Fwormbook.1.108.1\nFuxman Bass, 2015, Human gene-centered transcription factor networks for enhancers and disease variants, Cell, 161, 661, 10.1016\u002Fj.cell.2015.03.003\nGaudinier, 2011, Enhanced Y1H assays for Arabidopsis, Nat. Methods, 8, 1053, 10.1038\u002Fnmeth.1750\nGerstein, 2014, Comparative analysis of the transcriptome across distant species, Nature, 512, 445, 10.1038\u002Fnature13424\nGracida, 2013, Fertility and germline stem cell maintenance under different diets requires nhr-114\u002FHNF4 in C. elegans, Curr. Biol., 23, 607, 10.1016\u002Fj.cub.2013.02.034\nHarbison, 2004, Transcriptional regulatory code of a eukaryotic genome, Nature, 431, 99, 10.1038\u002Fnature02800\nHens, 2011, Automated protein-DNA interaction screening of Drosophila regulatory elements, Nat. Methods, 8, 1065, 10.1038\u002Fnmeth.1763\nHu, 2007, Genetic reconstruction of a functional transcriptional regulatory network, Nat. Genet., 39, 683, 10.1038\u002Fng2012\nJakobsen, 2007, Temporal ChIP-on-chip reveals Biniou as a universal regulator of the visceral muscle transcriptional network, Genes Dev., 21, 2448, 10.1101\u002Fgad.437607\nJothi, 2009, Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture, Mol. Syst. Biol., 5, 294, 10.1038\u002Fmsb.2009.52\nKamath, 2003, Systematic functional analysis of the Caenorhabditis elegans genome using RNAi, Nature, 421, 231, 10.1038\u002Fnature01278\nKemmeren, 2014, Large-scale genetic perturbations reveal regulatory networks and an abundance of gene-specific repressors, Cell, 157, 740, 10.1016\u002Fj.cell.2014.02.054\nKouns, 2011, NHR-23 dependent collagen and hedgehog-related genes required for molting, Biochem. Biophys. Res. 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Cell, 10, 797, 10.1016\u002Fj.devcel.2006.04.009\nTabuchi, 2011, Chromosome-biased binding and gene regulation by the Caenorhabditis elegans DRM complex, PLoS Genet., 7, e1002074, 10.1371\u002Fjournal.pgen.1002074\nVokes, 2008, A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb, Genes Dev., 22, 2651, 10.1101\u002Fgad.1693008\nWalhout, 2011, What does biologically meaningful mean? 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Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation, Cell Metab, 17, 49, 10.1016\u002Fj.cmet.2012.12.011\nBhatnagar, 2014\nBoyle, 2017, An expanded view of complex traits: from polygenic to omnigenic, Cell, 169, 1177, 10.1016\u002Fj.cell.2017.05.038\nBrowning, 2004, Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity, Hepatology, 40, 1387, 10.1002\u002Fhep.20466\nChakravarthy, 2009, Identification of a physiologically relevant endogenous ligand for PPARalpha in liver, Cell, 138, 476, 10.1016\u002Fj.cell.2009.05.036\nChambers, 2011, Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma, Nat. 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