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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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cancer treatment regimens such as chemotherapy and traditional chemical drugs have adverse side effects including the appearance of drug-resistant tumor cells. For these reasons, it is imperative to find novel therapeutic agents that overcome these factors. To this end, we explored a cationic antimicrobial peptide derived from Litopenaeus vannamei hemocyanin (designated LvHemB1) that induces cancer cell death, but sparing normal cells. LvHemB1 inhibits the proliferation of human cervical (HeLa), esophageal (EC109), hepatocellular (HepG2), and bladder (EJ) cancer cell lines, but had no significant effect on normal liver cell lines (T-antigen-immortalized human liver epithelial (THLE-3) cells). In addition to its antiproliferative effects, LvHemB1 induced apoptosis, by permeating cells and targeting mitochondrial voltage-dependent anion channel 1 (VDAC1). Colocalization studies revealed the localization of LvHemB1 in mitochondria, while molecular docking and pull-down analyses confirmed LvHemB1-VDAC1 interaction. Moreover, LvHemB1 causes loss in mitochondrial membrane potential and increases levels of reactive oxygen species (ROS) and apoptotic proteins (caspase-9, caspase-3, and Bax (Bcl-2-associated X)), which results in mitochondrial-mediated apoptosis. Thus, peptide LvHemB1 has the potential of being used as an anticancer agent due to its antiproliferation effect and targeting to VDAC1 to cause mitochondrial dysfunction in cancer cells, as well as its ability to induce apoptosis by increasing ROS levels, and the expression of proapoptotic proteins. \n                  \n                    \n                      \n                    \n                  \n                ",{"EN":1006},"LvHemB1, a novel cationic antimicrobial peptide derived from the hemocyanin of Litopenaeus vannamei, induces cancer cell death by targeting mitochondrial voltage-dependent anion channel 1",{"VOID":1008},"Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science. 1998;281:1322–6.\nBaker MA, Maloy WL, Zasloff M, Jacob LS. Anticancer efficacy of Magainin2 and analogue peptides. Cancer Res. 1993;53:3052–7.\nBalasubramanian K, Schroit AJ. Aminophospholipid asymmetry: a matter of life and death. Annu Rev Physiol. 2003;65:701–34.\nBaughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, et al. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature. 2011;476:341–5.\nBaxter AA, Lay FT, Poon IKH, Kvansakul M, Hulett MD. Tumor cell membrane-targeting cationic antimicrobial peptides: novel insights into mechanisms of action and therapeutic prospects. Cell Mol Life Sci. 2017;74:3809–25.\nBevers EM, Comfurius P, Zwaal RF. Regulatory mechanisms in maintenance and modulation of transmembrane lipid asymmetry: pathophysiological implications. Lupus. 1996;5:480–7.\nBrogden KA. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat Rev Microbiol. 2005;3:238–50.\nCadenas E, Davies KJ. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med. 2000;29:222–30.\nChen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66:115–32.\nCoates CJ, Decker H. Immunological properties of oxygen-transport proteins: hemoglobin, hemocyanin and hemerythrin. Cell Mol Life Sci. 2017;74:293–317.\nCoates CJ, Nairn J. Diverse immune functions of hemocyanins. Dev Comp Immunol. 2014;45:43–55.\nCoin I, Beyermann M, Bienert M. Solid-phase peptide synthesis: from standard procedures to the synthesis of difficult sequences. Nat Protoc. 2007;2:3247–56.\nDe Stefani D, Raffaello A, Teardo E, Szabò I, Rizzuto R. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature. 2011;476:336–40.\nDecker H, Rimke T. Tarantula hemocyanin shows phenoloxidase activity. J Biol Chem. 1998;273:25889–92.\nDehart DN, Fang D, Heslop K, Heslop K, Li L, Lemasters JJ, et al. Opening of voltage dependent anion channels promotes reactive oxygen species generation, mitochondrial dysfunction and cell death in cancer cells. Biochem Pharmcaol. 2018;148:155–62.\nDestoumieux-Garzón D, Saulnier D, Garnier J, Jouffrey C, Bulet P, Bachère E. Crustacean immunity: antifungal peptides are generated from the C terminus of shrimp hemocyanin in response to microbial challenge. J Biol Chem. 2001;276:47070–7.\nDobrzyńska I, Szachowicz-Petelska B, Sulkowski S, Figaszewski Z. Changes in electric charge and phospholipids composition in human colorectal cancer cells. Mol Cell Biochem. 2005;276:113–9.\nEpand RM, Vogel HJ. Diversity of antimicrobial peptides and their mechanisms of action. Biochim Biophys Acta. 1999;1462:11–28.\nFox JL. Antimicrobial peptides stage a comeback. Nat Biotechnol. 2013;31:379–82.\nGaspar D, Castanho MARB. Anticancer peptides: prospective innovation in cancer therapy. Springer International Publishing. 2016; 95-109.\nGreen DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281:1309–12.\nGreen DR, Galluzzi L, Kroemer G. Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science. 2011;333:1109–12.\nHancock RE. Peptide antibiotics. Lancet. 1997;349:418–22.\nHeslop KA, Rovini A, Hunt EG, Fang D, Morris ME, Christie CF, et al. JNK activation and translocation to mitochondria mediates mitochondrial dysfunction and cell death induced by VDAC opening and sorafenib in hepatocarcinoma cells. Biochem Pharmacol. 2020;171:113728.\nHilchie AL, Doucette CD, Pinto DM, Patrzykat A, Douglas S, Hoskin DW. Pleurocidin-family cationic antimicrobial peptides are cytolytic for breast carcinoma cells and prevent growth of tumor xenografts. Breast Cancer Res. 2011;13:R102.\nHuertas NJ, Monroy ZJR, Medina RF, Castañeda JEG. Antimicrobial activity of truncated and polyvalent peptides derived from the FKCRRQWQWRMKKGLA sequence against Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923. Molecules. 2017;22:987.\nJaenicke E, Föll R, Decker H. Spider hemocyanin binds ecdysone and 20-OH-ecdysone. J Biol Chem. 1999;274:34267–71.\nJin XB, Wang YJ, Liang LL, Pu QH, Shen J, Lu XM, et al. Cecropin suppresses human hepatocellular carcinoma BEL-7402 cell growth and survival in vivo without side-toxicity. Asian Pac J Cancer Prev. 2014;15:5433–6.\nKlein MJ, Schmidt S, Wadhwani P, Bürck J, Reichert J, Afonin S, et al. Lactam-stapled cell-penetrating peptides: cell uptake and membrane binding properties. J Med Chem. 2017;60:8071–82.\nKong LR, Chua KN, Sim WJ, Ng HC, Bi C, Ho J, et al. MEK inhibition overcomes cisplatin resistance conferred by SOS\u002FMAPK pathway activation in squamous cell carcinoma. Mol Cancer Ther. 2015;14:1750–60.\nKoo CY, Sen YP, Bay BH, Yip GW. Targeting heparan sulfate proteoglycans in breast cancer treatment. Recent Pat Anticancer Drug Discov. 2008;3:151–8.\nKufe DW. Mucins in cancer: function, prognosis and therapy. Nat Rev Cancer. 2009;9:874–85.\nLeanza L, Romio M, Becker KA, Azzolini M, Trentin L, Managò A, et al. Direct pharmacological targeting of a mitochondrial ion channel selectively kills tumor cells in vivo. Cancer Cell. 2017;31:516–31.\nLee SY, Lee BL, Söderhäll K. Processing of an antibacterial peptide from hemocyanin of the freshwater crayfish Pacifastacus leniusculus. J Biol Chem. 2003;278:7927–33.\nLi C, Zhu J, Wang Y, Chen Y, Song L, Zheng W, et al. Antibacterial activity of AI-Hemocidin 2, a novel N-terminal peptide of hemoglobin purified from Arca inflata. Mar Drugs. 2017;15:205.\nLi Y, Li L, Chen M, Yu X, Gu Z, Qiu H, et al. MAD2L2 inhibits colorectal cancer growth by promoting NCOA3 ubiquitination and degradation. Mol Oncol. 2018;12:391–405.\nLiu SJ, Zheng LY, Aweya JJ, Zheng Z, Zhong MQ, Chen JH, et al. Litopenaeus vannamei hemocyanin exhibits antitumor activity in S180 mouse model in vivo. PLoS One. 2017;12:e0183783.\nLiu SJ, Aweya JJ, Zheng LY, Wang F, Zheng Z, Zhong MQ, et al. A Litopenaeus vannamei hemocyanin-derived antimicrobial peptide (peptide B11) attenuates cancer cells' proliferation. Molecules. 2018;23:3202.\nMader JS, Hoskin DW. Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment. Expert Opin Investig Drugs. 2006;15:933–46.\nMader JS, Salsman J, Conrad DM, Hoskin DW. Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines. Mol Cancer Ther. 2005;4:612–4.\nMiller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, et al. Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 2016;66:271–89.\nMottis A, Herzig S, Auwerx J. Mitocellular communication: shaping health and disease. Science. 2019;366:827–32.\nMulder KC, Lima LA, Miranda VJ, Dias SC, Franco OL. Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides. Front Microbiol. 2013;4:321.\nNesterova NV, Zagorodnya SD, Moshtanska V, Dolashka P, Baranova GV, Golovan AV, et al. Antiviral activity of hemocyanin isolated from marine snail Rapana venosa. Antivir Res. 2011;90:A38.\nO’Brien-Simpson NM, Hoffmann R, Chia CSB, Wade JD. Editorial: antimicrobial and anticancer peptides. Front Chem. 2018;6:13.\nPaul RJ, Pirow R. The physiological significance of respiratory proteins in invertebrates. Zoology. 1997;100:298–306.\nPetit VW, Rolland JL, Blond A, Cazevieille C, Djediat C, Peduzzi J, et al. A hemocyanin-derived antimicrobial peptide from the penaeid shrimp adopts an alpha-helical structure that specifically permeabilizes fungal membranes. Biochim Biophys Acta. 2016;1860:557–68.\nPushpanathan M, Gunasekaran P, Rajendhran J. Antimicrobial peptides: versatile biological properties. Int J Pept. 2013;2013:675391.\nQiao J, Du ZH, Zhang YL, Du H, Guo LL, Zhong MQ, et al. Proteomic identification of the related immune-enhancing proteins in shrimp Litopenaeus vannamei stimulated with vitamin C and Chinese herbs. Fish Shellfish Immunol. 2011;31:736–45.\nRaman K, Kuberan B. Chemical tumor biology of heparan sulfate proteoglycans. Curr Chem Biol. 2010;4:20–31.\nRan S, Thorpe PE. Phosphatidylserine is a marker of tumor vasculature and a potential target for cancer imaging and therapy. Int J Radiat Oncol Biol Phys. 2002;54:1479–84.\nRiedl S, Zweytick D, Lohner K. Membrane-active host defense peptides – challenges and perspectives for the development of novel anticancer drugs. Chem Phys Lipids. 2011;164:766–81.\nRodrigues EG, Dobroff AS, Cavarsan CF, Paschoalin T, Nimrichter L, Mortara RA, et al. Effective topical treatment of subcutaneous murine B16F10-Nex2 melanoma by the antimicrobial peptide gomesin. Neoplasia. 2008;10:61–8.\nRoudi R, Syn NL, Roudbary M. Antimicrobial peptides as biologic and immunotherapeutic agents against cancer: a comprehensive overview. Front Immunol. 2017;8:1320.\nShoshan-Barmatz V, Mizrachi D, Keinan N. Oligomerization of the mitochondrial protein VDAC1: from structure to function and cancer therapy. Prog Mol Biol Transl Sci. 2013;117:303–34.\nShoshan-Barmatz V, Krelin Y, Shteinfer-Kuzmine A, Arif T. Voltage-dependent anion channel 1 as an emerging drug target for novel anti-cancer therapeutics. Front Oncol. 2017;7:154.\nSiegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68:7–30.\nStark M, Liu LP, Deber CM. Cationic hydrophobic peptides with antimicrobial activity. Antimicrob Agents Chemother. 2002;46:3585–90.\nTassanakajon A, Rimphanitchayakit V, Visetnan S, Amparyup P, Somboonwiwat K, Charoensapsri W, et al. Shrimp humoral responses against pathogens: antimicrobial peptides and melanization. Dev Comp Immunol. 2018;80:81–93.\nTorre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108.\nTrott O, Olson AJ. AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem. 2010;31:455–61.\nVega LA, Caparon MG. Cationic antimicrobial peptides disrupt the Streptococcus pyogenes ExPortal. Mol Microbiol. 2012;85:1119–32.\nWang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, et al. Superoxide flashes in single mitochondria. Cell. 2008;134:279–90.\nWang H, Ma JL, Yang YG, Song Y, Wu J, Qin YY, et al. Efficient therapeutic delivery by a novel cell-permeant peptide derived from KDM4A protein for antitumor and antifibrosis. Oncotarget. 2016;7:49075–90.\nWang X, Chen C, Zhou G, Ye J, Yin R, Feng D, et al. Sepia ink oligopeptide induces apoptosis of lung cancer cells via mitochondrial pathway. Cell Physiol Biochem. 2018;45:2095–106.\nWu Q, Yang Z, Nie Y, Shi Y, Fan D. Multi-drug resistance in cancer chemotherapeutics: mechanisms and lab approaches. Cancer Lett. 2014;347:159–66.\nWu X, Zhang H, Qi W, Zhang Y, Li J, Li Z, et al. Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis. Cell Death Dis. 2018;9:171.\nWysocka J. Identifying novel proteins recognizing histone modifications using peptide pull-down assay. Methods. 2006;40:339–43.\nYan F, Zhang YL, Jiang RP, Zhong MQ, Hu Z, Du H, et al. Identification and agglutination properties of hemocyanin from the mud crab (Scylla serrata). Fish Shellfish Immunol. 2011;30:354–60.\nYang S, Huang H, Wang F, Aweya JJ, Zheng ZH, Zhang YL. Prediction and characterization of a novel hemocyanin-derived antimicrobial peptide from shrimp Litopenaeus vannamei. Amino Acids. 2018;50:995–1005.\nYi Y, You X, Bian C, Chen S, Lv Z, Qiu L, et al. High-throughput identification of antimicrobial peptides from amphibious mudskippers. Mar Drugs. 2017;15:364.\nZhang YL, Wang SY, Peng XX. Identification of a type of human IgG-like protein in shrimp Penaeus vannamei by mass spectrometry. J Exp Mar Biol Ecol. 2004;301:39–54.\nZhang YL, Wang SY, Xu AL, Chen J, Lin BK, Peng XX. Affinity proteomic approach for identification of an IgA-like protein in Litopenaeus vannamei and study on its agglutination characterization. J Proteome Res. 2006;5:815–21.\nZhang YL, Yan F, Hu Z, Zhao XL, Min SY, Du ZH, et al. Hemocyanin from shrimp Litopenaeus vannamei shows hemolytic activity. Fish Shellfish Immunol. 2009;27:330–5.\nZheng LY, Zhao XL, Zhang P, Chen CD, Liu SJ, Huang R, et al. Hemocyanin from shrimp Litopenaeus vannamei has antiproliferative effect against HeLa cell in vitro. PLoS One. 2016;11:e0151801.\nZhu L, Yuan H, Guo C, Lu Y, Deng S, Yang Y, et al. Zearalenone induces apoptosis and necrosis in porcine granulosa cells via a caspase-3- and caspase-9-dependent mitochondrial signaling pathway. J Cell Physiol. 2012;227:1814–20.\nZhu Y, Dean AE, Horikoshi N, Heer C, Spitz DR, Gius D. Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy. J Clin Invest. 2018;128:3682–91.\nZitvogel L, Apetoh L, Ghiringhelli F, Kroemer G. Immunological aspects of cancer chemotherapy. 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anti-inflammatory drugs can cause serious side-effects such as tubulo-interstitial nephritis. Mesalazine (5-ASA, 5-aminosalicylic acid) is used for the treatment of colitis ulcerosa, Crohn disease, and other diseases; it has been found to induce necrosis of both proximal convoluted tubules and renal papillaries. The comparative cytotoxicity of 3-, 4-, and 5- aminosalicylic acid, acetylsalicylic acid (AcSA), and the parent compound salicylic acid (SA) was investigated for the free acids and for their sodium salts. The interaction with endogenous glutathione (GSH) was also investigated. Four established cell lines were used: MDCK, LLC-PK1, NRK as renal cells, and HepG2 as hepatic cells. The free acid compounds were less toxic than their corresponding salts. Acidic 5-ASA was the most toxic of the three isomers in MDCK and LLC-PK1 cells, while NRK and HepG2 were more susceptible to acidic 3-ASA. Addition of NaOH modified the relative toxicity of 3-ASA and 5-ASA. The LLC-PK1 and HepG2 cells were more sensitive to the test chemicals as their salts than were the NRK and MDCK cells. SA and 5-ASA decreased the GSH content in renal cells and increased it in HepG2. GSH depletion with l-buthionine-(S,R)-sulfoximine enhanced the toxicity only for SA in NRK and for 5-ASA and AcSA in HepG2. No correlation between endogenous GSH and the susceptibility of MDCK and LLC-PK1 to the test compounds was observed. The results suggest that no typical nephrotoxic effect occurred. No explanation could be found for the tubulo-interstitial nephritis caused by 5-ASA therapy.",{"EN":1273},"Comparative cytotoxicity of 5-aminosalicylic acid (mesalazine) and related compounds in different cell lines",{"VOID":1275},"Babich H, Borenfreund E. Application of the neutral red cytotoxicity assay to in vitro toxicology. ATLA. 1990;18:129–44.\nBarbour VM, Williams PF. Nephrotoxic syndrome associated with sulphasalazine. Br Med J. 1990;301:818.\nBoelsterli AU, Zimmerman HJ, Kretz-Rommel A. Idiosyn-cratic liver toxicity of nonsteroidal antiinflammatory drugs: molecular mechanisms and pathology. Crit Rev Toxicol. 1995;25:207–35.\nBohets HH, Nouwen EJ, De Broe ME, Dierickx PJ. Effects of foetal calf serum on cell viability, cytotoxicity and detox-ification in the two kidney-derived cell lines LLC-PK1 and MDCK. Toxicol In Vitro. 1994;8:559–61.\nCalder IC, Funder CC, Green CR, Ham KN, Tange JD. Comparative nephrotoxicity of aspirin and phenacetin deri-vates. Br Med J. 1971;4:518–21.\nCalder IC, Funder CC, Green CR, Ham KN, Tange JD. Nephrotoxic lesions from 5-aminosalicylic acid. Br Med J. 1972;1:152–4.\nDuthie SJ, Coleman CS, Grant MH. Status of reduced glu-tathione in the human hepatoma cell line, Hep G2. Biochem Pharmacol. 1988;37:3365–8.\nEllman GL. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959;82:70–7.\nEngelhardt G, Homma D. Effects of acetylsalicylic acid, para-cetamol and caffeine and a combination of these substances on kidney glutathione levels. Drug Res. 1996;46:413–518.\nFernando AHN, Temple RM, Thomas S, Lee HA. Renal failure after topical use of NSAIDs. Br Med J. 1994;308:533.\nFlower RJ, Drugs which inhibit prostaglandin biosynthesis. Pharmacol Rev. 1974;26:33–67.\nJurima-Romet M, Crawford K, Huang HS. Comparative cytotoxicity of non-steroidal anti-inflammatory drugs in primary cultures of rat hepatocytes. Toxicol In Vitro. 1994;8:55–66.\nLewis JH. Hepatic toxicity of nonsteroidal antiinflammatory drugs. Clin Pharm. 1984;3:128–38.\nLowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265–75.\nMarteau P, Halphen M. Comparative randomized open study of the efficacy and tolerance of enemas with 2 gr of 4-amino-salicylic acid (4-ASA) and 1 gr of 5-amino-salicylic acid (5-ASA) in distal forms of hemorrhagic rectocolitis. Gastro-enterol Clin Biol. 1995;19:31–5.\nMcCormack K, Brune K. Classical absorption theory and the development of gastric mucosal damage associated with the non-steroidal anti-inflammatory drugs. Arch Toxicol. 1987;60:261–9.\nMorin JP, Leclere C, Marouillat S, Monteil C. Some milestones in in vitro organ toxicity assessment. The kidney as a case study. Toxicol In Vitro. 1995;9:795–814.\nMurray MD, Brater DC. Renal toxicity of the nonsteroidal antiinflammatory drugs. Annu Rev Pharmacol Toxicol. 1993;33:434.\nNovis BH, Korzets Z, Chen P, Bernheim J. Nephrotic syn-drome after treatment with 5-aminosalicylic acid. Br Med J. 1988;296:1442.\nSorensen EMB, Acosta D. Relative toxicities of several nonster-oidal antiinflammatory compounds in primary cultures of rat hepatocytes. 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They have been widely used in fundamental studies on hematopoiesis and they are also routinely used in clinical hematology to confirm diagnosis or to predict time to recovery in cases of bone marrow failure. Their use in toxicological studies is more recent. Adverse effects of xenobiotics can induce hematological problems and pathologies such as neutropenia, thrombocytopenia, anemia, and aplastic anemia. Three clonogenic assays are proposed for granulopoiesis, megakaryopoieisis and erythropoieisis. Hematopoietic progenitors from murine or human origin can be cultured in the presence of xenobiotics using validated protocols to complete standard animal toxicological studies. These clonogenic assays can help to predict adverse effects of drugs or toxicants. Clonogenic assays using white blood cell progenitors (CFU-GM culture) have recently been validated by ECVAM and can be used routinely. Megakaryocyte progenitor (CFU-MK) culture is under development and prevalidation in toxicological studies supported by ECVAM. Red blood cells progenitor culture (BFU-E) has been proposed but needs international validation to be recognized.",{"EN":1390},"Relevance of clonogenic assays in hematotoxicology",{"EN":1392},"",{"VOID":1394},"10.1023\u002FA:1010906104558",[31],"https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1023\u002FA:1010906104558",[1398],{"id":1399,"sortIndex":32,"researcher":28,"roles":1400,"affiliations":1401,"properties":1410,"displayName":1412,"givenName":28,"familyName":28},"ef42a99a-0c7f-4e40-80b2-c879953b16aa",[],[1402],{"id":1403,"sortIndex":32,"affiliation":1404,"properties":28},"68a59932-1b26-4e97-b571-c11a1df0c4ce",{"id":1403,"createTime":28,"updateTime":28,"relativeEntities":1405,"slug":28,"properties":1406,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1409,"statistic":28},[],{"title":1407},{"EN":1408},"Laboratoire de Microbiologie et Sécurité Alimentaire, Ecole Supérieure de Microbiologie et Sécurité Alimentaire de Brest, ESMISAB\u002FISAMOR, Plouzané, France",[],{"title":1411},{"EN":1412},"D. 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Quinidine-induced neutropenia: a drug-dependent inhibition of granulocyte colony generation. Acta Haematol. 1984;72:349–54.",{"id":28,"text":1471,"url":28,"identifiers":28},"Amess J. Haematotoxicology. In: Ballantine B, Marrs T, Turner P, eds. General and applied toxicology. The MacMillan Press; 1993;1:839–67.",{"id":28,"text":1473,"url":28,"identifiers":28},"Barret AJ, Weller E, Rozengurt N, Longhurst P, Humble JG. Amidopyrine agranulocytosis: drug inhibition of granulocyte colonies in the presence of patient's serum. Br Med J. 1976;ii:850–1.",{"id":28,"text":1475,"url":28,"identifiers":28},"Casati S, Collotta A, Gribaldo L. Human umbilical cord blood and bone marrow as a source of CD34+ CD38- cells for the in vitro CFU-MK assay. ATLA. 1999;27:120. [Abstract].",{"id":28,"text":1477,"url":28,"identifiers":28},"Daniniak N, Worthington M, Riordan MA, Kreczko S, Goldman L. 3′-Azido-3′-deoxythimidine (AZT) inhibits proliferation in vitro of human haematopoietic progenitor cells. Br J Haematol. 1988;69:299–304.",{"id":28,"text":1479,"url":28,"identifiers":28},"Deldar A, Stevens CE. Development and application of in vitro models of hematopoiesis to drug development. Toxicol Pathol. 1993;21:231–40.",{"id":28,"text":1481,"url":28,"identifiers":28},"Dellmann HD. Textbook of veterinary histology, 4th ed. Malvern, PA: Lea & Febinger; 1993:66.",{"id":28,"text":1483,"url":28,"identifiers":28},"Erslev AJ. Pure red cell aplasia. In: Williams WJ, Beutler E, Erslev AJ, Lichtman MA, eds. Hematology, 4th ed. New York: Mc Graw Hill; 1990;430–8.",{"id":28,"text":1485,"url":28,"identifiers":28},"Froquet R, Rio B, Sibiril Y, Parent-Massin D. Improvement of megakaryocyte clonogenic assay for toxicological investigations. ATLA. 1999;27:361. [Abstract].",{"id":28,"text":1487,"url":28,"identifiers":28},"Froquet R, Sibiril Y, Parent-Massin D. Improvement of megakaryocte progenitor culture for toxicological investigations. Toxicol In Vitro. 2001 [In press].",{"id":28,"text":1489,"url":28,"identifiers":28},"Gribaldo L, Casati S, Figliuzzi L, Marafante E. In vitro myclotoxicity of environmental contaminants. Environ Toxicol Pharmacol. 1998;6:135–41.",{"id":28,"text":1491,"url":28,"identifiers":28},"Gribaldo L, Casati S, Castoldi AF, Pessina A. Comparison of in vitro drug-sensitivity of human granulocyte-macrophage progenitors from two different origins: umbilical cord blood and bone marrow. Exp Hematol. 1999;27:1593–8.",{"id":28,"text":1493,"url":28,"identifiers":28},"Irvine AE, Morris TCM, Kelly CJ, McCraken N. Tirarcillin-induced neutropenia corroborated by in vitro CFU-C toxicity. Acta Haematol. 1983;70:364–8.",{"id":28,"text":1495,"url":28,"identifiers":28},"Kelton JG, Huang AT, Mold N, Logue GL, Rosse WF. The use of in vitro techniques to study drug-induced pancytopenia. N Engl J Med. 1979;301:621–4.",{"id":28,"text":1497,"url":28,"identifiers":28},"Lautraite S, Parent-Massin D, Rio B, Hoellinger H. Comparison of toxicity induced by T-2 toxin on human and rat granulo-monocytic progenitors with an in vitro model. Hum Exp Toxicol. 1995;14:672–8.",{"id":28,"text":1499,"url":28,"identifiers":28},"Lind DE, Levi JA, Vincent PC. Amodiaquine-induced agranulocytosis: toxic effect of amodiaquine in bone marrow cultures in vitro. Br Med J. 1973;1:458–60.",{"id":28,"text":1501,"url":28,"identifiers":28},"Lord BI, Testa NG. The hemopoietic system: structure and regulation. In: Testa NG, Gale RP, eds. Hemopoiesis: long-term effects of chemotherapy and radiation. New York: Marcel Dekker; 1988:1–26.",{"id":28,"text":1503,"url":28,"identifiers":28},"Lutton JD, Ibraham NG, Friedland M, Levere RD. The toxic effects of heavy metal on rat bone marrow in vitro erythropoiesis: protective role of hemin and zinc. Environ Res. 1984;35:97–103.",{"id":28,"text":1505,"url":28,"identifiers":28},"Lutton JD, Mathew A, Levere RD, Abraham NG. Role of heme metabolism in AZT-induced bone marrow toxicity. Am J Hematol. 1990;35:1–5.",{"id":28,"text":1507,"url":28,"identifiers":28},"Parchment RE, Volpe DA, LoRusso PM, Erickson-Miller CL, Murphy MJ, Grieshaber CK. In vivo-in vitro correlation of myelotoxicity of 9-methoxypyrazoloacridine (NSC-366140, PD115934) to myeloid and erythroid hematopoietic progenitors from human, murine, and canine marrow. J Natl Cancer Inst. 1994;86:273–80.",{"id":28,"text":1509,"url":28,"identifiers":28},"Parchment R, Gordon M, Grieshaber CK, Sessa C, Volpe D, Ghielmini M. Predicting haematological toxicity (myelosuppression) of cytotoxic drug therapy from in vitro tests. Ann Oncol. 1998;9:357–64.",{"id":28,"text":1511,"url":28,"identifiers":28},"Parent-Massin D, Thouvenot D. In vitro study of pesticide hematotoxicity in human and rat progenitors. J Pharmacol Toxicol Methods. 1993;30:203–7.",{"id":28,"text":1513,"url":28,"identifiers":28},"Parent-Massin D, Sensebé L, Leglise MC, et al. Relevance of in vitro studies of drug-induced agranulocytosis. Drug Safety. 1993;9:463–9.",{"id":28,"text":1515,"url":28,"identifiers":28},"Parent-Massin D, Fuselier R, Thouvenot D. In vitro toxicity of trichothecenes on human haematopoietic progenitors. Food Addit Contam. 1994;11:441–7.",{"id":28,"text":1517,"url":28,"identifiers":28},"Parent-massin D, Fournier V, Amade P, et al. Evaluation of the toxicological risk to humans of caulerpenyne using human hematopoietic progenitors, melanocytes, and keratinocytes in culture. J Toxicol Environ Health. 1996;47:47–59.",{"id":28,"text":1519,"url":28,"identifiers":28},"Pessina A, Albella B, Bueren J, et al. Method development for a prevalidation study of the in vitro GM-CFU assay for predicting myelotoxicity. In: Balls M, van Zeller M, Halder ME, eds. Progress in the reduction, refinement and replacement of animal experimentation. Amsterdam: Elsevier Science; 2000:679–92.",{"id":28,"text":1521,"url":28,"identifiers":28},"Rio B, Lautraite S, Parent-Massin D. In vitro toxicity of trichothecenes on human erythroblastic progenitors. Hum Exp Toxicol. 1997a;16:673–9.",{"id":28,"text":1523,"url":28,"identifiers":28},"Rio B, Parent-Massin D. Improvement of erythroblastic progenitor culture for toxicological investigations. Toxicol Methods. 1997b;7:363–80.",{"id":28,"text":1525,"url":28,"identifiers":28},"Rio B, Parent-Massin D. Effects of diphenyl-ether herbicide oxyfluorfen on human BFU-E\u002FCFU-E development and hemoglobin synthesis. Hum Exp Toxicol. 1997c;16:11–22.",{"id":28,"text":1527,"url":28,"identifiers":28},"Van den Heuvel R, Leppens H, Bertels N, Schoeters G. Comparison of haematotoxicity induced by lead and the benzene metabolites catechol and hydroquinone on human and murine haematopoietic progenitor cells using in vitro assays. Cell Biol Toxicol. 1999a;15:101–10.",{"id":28,"text":1529,"url":28,"identifiers":28},"Van den Heuvel R, Leppens H, Nuyten J-M, Schoeters G. Haematopoietic lineage sensitivity and individual susceptibility to PCB126: relation to glutathione-S-transferase. Toxicol In Vitro. 1999b;13:605–9.",{"id":28,"text":1531,"url":28,"identifiers":28},"Yamaguchi F, Furuhama K, Miyamoto M, Sagara-Ishijama N, Takayama S. Application of hematopoietic progenitors assays for the estimation of hematotoxicity in rats. J Pharmacol Toxicol Methods. 1994;31:71–7.",{"id":28,"text":1533,"url":28,"identifiers":28},"Young NS. Drugs and chemicals. In: Young NS, ed. Aplastic anemia, acquired and inherited. Philadelphia, PA: Saunders; 1994:100.",{"id":28,"text":1535,"url":28,"identifiers":28},"Yunis AA, Miller AM, Salem Z, Arimura GK. Chloramphenicol toxicity: pathogenetic mechanisms and the role of the p-NO2 in aplastic anemia. Clin Toxicol. 1980;17:359–73.",{"id":1537,"createTime":1538,"updateTime":1539,"relativeEntities":1540,"slug":1541,"properties":1542,"entityType":1011,"verifyStatus":26,"verifyTime":1539,"verifyNote":1012,"languages":28,"translateLanguages":28,"viewCount":32,"primaryUrl":1551,"fullTextUrl":28,"authors":1552,"publicationType":1202,"publisherRelationship":1635,"citationCount":28,"citationInfo":28,"publishDate":1691,"publishYear":1692,"citationAnalyzeStatus":880,"lastCitationAnalyze":28,"indexDatabases":1693,"openAccess":28,"references":28,"isForceReanalyzing":1262},"00a5622a-227f-4fd8-90c8-4d0694826937","2024-02-08T16:23:36.100+00:00","2024-12-28T00:18:46.242+00:00",[],"Cellular-impact-of-combinations-of-endosulfan-atrazine-and-chlorpyrifos-on-human-primary-hepatocytes-and-HepaRG-cells-after-short-and-chronic-exposures",{"abstract":1543,"title":1545,"references":1547,"doi":1549},{"EN":1544},"Chronic exposure to low doses of pesticides present in the environment is increasingly suspected to cause major health issues to humans. Toxicological evaluations become more complex when the exposure concerns chemical combinations. Atrazine, chlorpyrifos, and endosulfan are pesticides used worldwide in agriculture and are therefore currently found at residual levels in food and the environment, even in countries in which they are now banned. Our study aimed to use Real-Time Cell Impedance Analyzer to investigate changes in phenotypical status of primary human hepatocytes and differentiated HepaRG cells induced by short and chronic exposures to these three chemicals. In contrast to the traditionally used endpoint cytotoxicity test, this technology allows kinetic measurements in real-time throughout the entire experiment. Our data show significantly higher cytotoxic effects of mixtures as compared to individual pesticides and a greater susceptibility of human hepatocytes as compared to HepaRG to short-term exposure (24 h). Repeated exposure over 2 weeks to endosulfan and endosulfan-containing mixture induced HepaRG cell death in a time- and dose-dependent manner. Of the typical genes involved in metabolism and cell-response to xenobiotics, we found an exposure time- and condition-dependent deregulation of the expression of CYP3A4 and UGT1A in HepaRG cells exposed to low doses of pesticides and mixtures. Our data demonstrate the usefulness of real-time cell monitoring in long-term toxicological evaluations of co-exposure to xenobiotics. In addition, they support but at the same time highlight certain limitations in the use of HepaRG cells as the gold standard liver cell model in toxicity studies.",{"EN":1546},"Cellular impact of combinations of endosulfan, atrazine, and chlorpyrifos on human primary hepatocytes and HepaRG cells after short and chronic exposures",{"VOID":1548},"Abass K, Lamsa V, Reponen P, Kublbeck J, Honkakoski P, Mattila S, et al. Characterization of human cytochrome P450 induction by pesticides. Toxicology. 2012;294:17–26.\nAckerman F. The economics of atrazine. Int J Occup Environ Health. 2007;13:437–45.\nAtienza JM, Zhu J, Wang X, Xu X, Abassi Y. Dynamic monitoring of cell adhesion and spreading on microelectronic sensor arrays. J Biomol Screen. 2005;10:795–805.\nBebe FN, Panemangalore M. Exposure to low doses of endosulfan and chlorpyrifos modifies endogenous antioxidants in tissues of rats. J Environ Sci Health B. 2003;38:349–63.\nBertz RJ, Granneman GR. Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions. Clin Pharmacokinet. 1997;32:210–58.\nBisson M, Hontela A. Cytotoxic and endocrine-disrupting potential of atrazine, diazinon, endosulfan, and mancozeb in adrenocortical steroidogenic cells of rainbow trout exposed in vitro. Toxicol Appl Pharmacol. 2002;180:110–7.\nBlair A, Zahm SH. Agricultural exposures and cancer. Environ Health Perspect. 1995;103 Suppl 8:205–8.\nCairns T, Sherma J, editors. Emerging Strategies for Pesticide Analysis. Boca Raton, Florida, USA: CRC Press; 1992.\nChade AR, Kasten M and Tanner CM. Nongenetic causes of Parkinson’s disease. J Neural Transm Suppl 2006; 147-151.\nCometa MF, Buratti FM, Fortuna S, Lorenzini P, Volpe MT, Parisi L, et al. Cholinesterase inhibition and alterations of hepatic metabolism by oral acute and repeated chlorpyrifos administration to mice. Toxicology. 2007;234:90–102.\nDas PC, McElroy WK, Cooper RL. Differential modulation of catecholamines by chlorotriazine herbicides in pheochromocytoma (PC12) cells in vitro. Toxicol Sci. 2000;56:324–31.\nDas PC, Cao Y, Rose RL, Cherrington N, Hodgson E. Enzyme induction and cytotoxicity in human hepatocytes by chlorpyrifos and N, N-diethyl-m-toluamide (DEET). Drug Metabol Drug Interact. 2008;23:237–60.\nde Sousa G, Langouët S, Nicolas F, Lorenzon G, Placidi M, Rahmani R, Guillouzo A. Increase of cytochrome P-450 1A and glutathione transferase transcripts in cultured hepatocytes from dogs, monkeys, and humans after cryopreservation. Cell Biol Toxicol. 1996;12:351–8.\nEJF. End of the Road for Endosulfan: pushing for a global ban on a deadly pesticide. Environmental Justice Foundation, London, UK; 2009. Second version.\nFan W, Yanase T, Morinaga H, Gondo S, Okabe T, Nomura M, et al. Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans. Environ Health Perspect. 2007;115:720–7.\nGao J, Xie W. Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism. Drug Metab Dispos. 2010;38:2091–5.\nGarry VF, Schreinemachers D, Harkins ME, Griffith J. Pesticide appliers, biocides, and birth defects in rural Minnesota. Environ Health Perspect. 1996;104:394–9.\nGerets HH, Tilmant K, Gerin B, Chanteux H, Depelchin BO, Dhalluin S, et al. Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol. 2012;28:69–87.\nGilot D, Loyer P, Corlu A, Glaise D, Lagadic-Gossmann D, Atfi A, et al. Liver protection from apoptosis requires both blockage of initiator caspase activities and inhibition of ASK1\u002FJNK pathway via glutathione S-transferase regulation. J Biol Chem. 2002;277:49220–9.\nGomez-Lechon M, Donato M, Castell J, Jover R. Human hepatocytes as a tool for studying toxicity and drug metabolism. Curr Drug Metab. 2003;4:292–312.\nGripon P, Rumin S, Urban S, Le Seyec J, Glaise D, Cannie I, Guyomard C, Lucas J, Trepo C, Guguen-Guillouzo C. Infection of a human hepatoma cell line by hepatitis B virus. Proc Natl Acad Sci U S A. 2002;99:15655–60.\nGuillouzo A, Corlu A, Aninat C, Glaise D, Morel F, Guguen-Guillouzo C. The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chem Biol Interact. 2007;168:66–73.\nHanioka N, Obika N, Nishimura M, Jinno H, Tanaka-Kagawa T, Saito K, et al. Inducibility of UDP-glucuronosyltransferase 1As by beta-naphthoflavone in HepG2 cells. Food Chem Toxicol. 2006;44:1251–60.\nHaviland JA, Butz DE, Porter WP. Long-term sex selective hormonal and behavior alterations in mice exposed to low doses of chlorpyrifos in utero. Reprod Toxicol. 2010;29:74–9.\nHeistad DD. Oxidative Stress and Vascular Disease 2005 Duff Lecture. Arterioscler Thromb Vasc Biol. 2006;26:689–95.\nJondeau A, Dahbi L, Bani-Estivals MH, Chagnon MC. Evaluation of the sensitivity of three sublethal cytotoxicity assays in human HepG2 cell line using water contaminants. Toxicology. 2006;226:218–28.\nLafiura KM, Bielawski DM, Posecion Jr NC, Ostrea Jr EM, Matherly LH, Taub JW, et al. Association between prenatal pesticide exposures and the generation of leukemia-associated T(8;21). Pediatr Blood Cancer. 2007;49:624–8.\nLambert CB, Spire C, Claude N, Guillouzo A. Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol. 2009;234:345–60.\nLarsen JC, Binderup M-L, Dalgaard M, Dragsted LO, Hossaini A, Ladefoged O, et al. Combined actions and interactions of chemicals in mixtures. The toxicological effects of exposure to mixtures of industrial and environmental chemicals. Danish Veterinary and Food Administration. FødevareRapport 12. 2003.\nLeCluyse E, Madan A, Hamilton G, Carroll K, DeHaan R, Parkinson A. Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes. J Biochem Mol Toxicol. 2000;14:177–88.\nLemaire G, de Sousa G, Rahmani R. A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides. Biochem Pharmacol. 2004;68:2347–58.\nMcMullin TS, Andersen ME, Nagahara A, Lund TD, Pak T, Handa RJ, et al. Evidence that atrazine and diaminochlorotriazine inhibit the estrogen\u002Fprogesterone induced surge of luteinizing hormone in female Sprague–Dawley rats without changing estrogen receptor action. Toxicol Sci. 2004;79:278–86.\nMedina-Diaz IM, Rubio-Ortiz M, Martinez-Guzman MC, Davalos-Ibarra RL, Rojas-Garcia AE, Robledo-Marenco ML, et al. Organophosphate pesticides increase the expression of alpha glutathione S-transferase in HepG2 cells. Toxicol In Vitro. 2011;25:2074–9.\nMeinert R, Schuz J, Kaletsch U, Kaatsch P, Michaelis J. Leukemia and non-Hodgkin’s lymphoma in childhood and exposure to pesticides: results of a register-based case–control study in Germany. Am J Epidemiol. 2000;151:639–46. discussion 647-650.\nMendola P, Selevan SG, Gutter S, Rice D. Environmental factors associated with a spectrum of neurodevelopmental deficits. Ment Retard Dev Disabil Res Rev. 2002;8:188–97.\nNakata K, Tanaka Y, Nakano T, Adachi T, Tanaka H, Kaminuma T, et al. Nuclear receptor-mediated transcriptional regulation in Phase I, II, and III xenobiotic metabolizing systems. Drug Metab Pharmacokinet. 2006;21:437–57.\nPistl J, Kovalkovicova N, Holovska V, Legath J, Mikula I. Determination of the immunotoxic potential of pesticides on functional activity of sheep leukocytes in vitro. Toxicology. 2003;188:73–81.\nRomero L, Andrews K, Ng L, O'Rourke K, Maslen A, Kirby G. Human GSTA1-1 reduces c-Jun N-terminal kinase signalling and apoptosis in Caco-2 cells. Biochem J. 2006;400:135–41.\nRouimi P, Zucchini-Pascal N, Dupont G, Razpotnik A, Fouche E, De Sousa G, et al. Impacts of low doses of pesticide mixtures on liver cell defence systems. Toxicol In Vitro. 2012;26:718–26.\nRoy JR, Chakraborty S, Chakraborty TR. Estrogen-like endocrine disrupting chemicals affecting puberty in humans–a review. Med Sci Monit. 2009;15:RA137–45.\nSawicki B, Durand G, Dewitte JD, Ratanasavanh D, Riche C, Leglise MC. Myelosuppressive activity of two herbicides, atrazine and dinoterb, on human haematopoietic progenitor cells: An in vitro assay to evaluate the effects of intermediate or long-term exposure. Toxicol In Vitro. 1998;12:183–90.\nScremin OU, Chialvo DR, Lavarello S, Berra HH, Lucero MA. The environmental pollutant endosulfan disrupts cerebral cortical function at low doses. Neurotoxicology. 2011;32:31–7.\nSilva MH, Gammon D. An assessment of the developmental, reproductive, and neurotoxicity of endosulfan. Birth Defects Res B Dev Reprod Toxicol. 2009;86:1–28.\nSoars MG, Petullo DM, Eckstein JA, Kasper SC, Wrighton SA. An assessment of udp-glucuronosyltransferase induction using primary human hepatocytes. Drug Metab Dispos. 2004;32:140–8.\nSolly K, Wang X, Xu X, Strulovici B, Zheng W. Application of real-time cell electronic sensing (RT-CES) technology to cell-based assays. Assay and drug development technologies. 2004;2:363–72.\nSugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, et al. The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology. 2001;33:1232–8.\nSugatani J, Uchida T, Kurosawa M, Yamaguchi M, Yamazaki Y, Ikari A, et al. Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein. Drug Metab Dispos. 2012;40(10):2031–40.\nTchounwou PB, Wilson BA, Ishaque AB, Schneider J. Atrazine potentiation of arsenic trioxide-induced cytotoxicity and gene expression in human liver carcinoma cells (HepG2). Mol Cell Biochem. 2001;222:49–59.\nThrasher JD, Heuser G, Broughton A. Immunological abnormalities in humans chronically exposed to chlorpyrifos. Arch Environ Health. 2002;57:181–7.\nTyler Mehler W, Schuler LJ, Lydy MJ. Examining the joint toxicity of chlorpyrifos and atrazine in the aquatic species: Lepomis macrochirus, Pimephales promelas and Chironomus tentans. Environ Pollut. 2008;152:217–24.\nUrquhart BL, Tirona RG, Kim RB. Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs. J Clin Pharmacol. 2007;47:566–78.\nWarren N, Allan I, Carter J, House W, Parker A. Pesticides and other micro-organic contaminants in freshwater sedimentary environments: a review. Appl Geochem. 2003;18:159–94.\nWirdefeldt K, Adami HO, Cole P, Trichopoulos D, Mandel J. Epidemiology and etiology of Parkinson’s disease: a review of the evidence. Eur J Epidemiol. 2011;26 Suppl 1:S1–S58.\nXi B, Yu N, Wang X, Xu X, Abassi YA. The application of cell-based label-free technology in drug discovery. Biotechnol J. 2008;3:484–95.\nXie W, Barwick JL, Simon CM, Pierce AM, Safe S, Blumberg B, et al. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR\u002FPXR and CAR. Genes Dev. 2000;14:3014–23.\nXie W, Yeuh MF, Radominska-Pandya A, Saini SP, Negishi Y, Bottroff BS, et al. Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Proc Natl Acad Sci U S A. 2003;100:4150–5.",{"VOID":1550},"10.1007\u002Fs10565-013-9266-x","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs10565-013-9266-x",[1553,1568,1581,1596,1609,1622],{"id":1554,"sortIndex":32,"researcher":28,"roles":1555,"affiliations":1556,"properties":1565,"displayName":1567,"givenName":28,"familyName":28},"a6a00bcb-83f8-4b95-ad5a-ac2701183996",[1018],[1557],{"id":1558,"sortIndex":32,"affiliation":1559,"properties":28},"48f8f947-181f-4c49-8a76-cc66c9011092",{"id":1558,"createTime":28,"updateTime":28,"relativeEntities":1560,"slug":28,"properties":1561,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":1564,"statistic":28},[],{"title":1562},{"VI":1563},"Institut National de la Recherche Agronomique (INRA), Laboratoire de Toxicologie Cellulaire et Moléculaire des Xénobiotiques, UMR 1331, Sophia-Antipolis Cedex, France",[],{"title":1566},{"VI":1567},"Ahmad 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nephrotoxic fungal toxins ochratoxin A (OA), ochratoxin B (OB) and citrinin (CIT) are natural contaminants of foods and feeds. While cytotoxicity assays have proven useful for establishing relative toxicity and structure–function relationships within groups of fungal toxins, a drawback of in vitro bioassays is their susceptibility to variation depending on endpoint, target cell, and dosing strategy. These variables were explored for OA, OB, CIT using two continuous kidney cell lines (LLC-PK1 and OK) and four cytotoxicity assay endpoints. The nephrotoxic antibiotic gentamicin was used as a positive control for cytotoxicity throughout. In general, fungal toxin-induced cytotoxicity was more pronounced in LLC-PK1 cultures using mitochondrial dehydrogenase inhibition (MTT assay) as the endpoint. Altered dosing strategy, but not seeding density, consistently influenced cytotoxicity: CIT was more toxic to cells when added at the time of seeding, whereas OA was more toxic when added 24 h after cultures were seeded. Toxicity rankings for the fungal toxins were consistent with in vivo studies and were, in order of most to least toxic, OA>OB>CIT. The data indicate that LLC-PK1 and OK cells compare favorably to existing models in terms of sensitivity to nephrotoxic fungal toxins, but also that relatively minor changes in assay protocols can affect the cytotoxicity of individual toxins and comparative toxicity within a group of toxins.",{"EN":1704},"Cytotoxicity of Nephrotoxic Fungal Toxins to Kidney-derived LLC-PK1 and OK Cell Lines",{"VOID":1706},"citation_journal_title=Gen Pharmaol.; citation_title=Gentamicin nephrotoxicity in humans and animals: some recent research; citation_author=BH. Ali; citation_volume=26; citation_publication_date=1995; citation_pages=1477-87; citation_id=CR1\ncitation_journal_title=J Pharmacol Exp Ther.; citation_title=Some toxicological and pharmacological properties of citrinin; citation_author=AM Ambrose, F. DeEds; citation_volume=88; citation_publication_date=1946; citation_pages=173-86; citation_id=CR2\ncitation_journal_title=Toxicon; citation_title=Murine lymphocyte proliferation impaired by substituted neosolaniols and calonectrins-metabolites associated with tri-chothecene biosynthesis; citation_author=GS Bondy, SP McCormick, MN Beremand, JJ. Pestka; citation_volume=29; citation_publication_date=1991; citation_pages=1107-13; citation_id=CR3\ncitation_journal_title=Toxicol Lett.; citation_title=Toxicity determined in vitro by morphological alterations and neutral red absorption; citation_author=E Borenfreund, JA. Puerner; citation_volume=24; citation_publication_date=1985; citation_pages=119-24; citation_id=CR4\ncitation_journal_title=Fund Appl Toxicol.; citation_title=Evaluation of drug and chemical toxicity with cell culture systems; citation_author=JA. Bradlaw; citation_volume=6; citation_publication_date=1986; citation_pages=598-606; citation_id=CR5\ncitation_journal_title=J Appl Toxicol.; citation_title=Mechanism of citrinin-induced dysfunction of mitochondria. I. Effects on respiration, enzyme activities and membrane potential of renal cortical mitochondria; citation_author=GM Chagas, AP Campello, LW. Klüppel; citation_volume=12; citation_publication_date=1992; citation_pages=123-9; citation_id=CR6\ncitation_journal_title=Cell Biochem Funct.; citation_title=Mechanism of citrinin-induced dysfunction of mitochondria. II. Effect on respiration, enzyme activities, and membrane potential of liver mitochondria; citation_author=GM Chagas, BM Oliveira, AP Campello, LW. Klüppel; citation_volume=10; citation_publication_date=1992; citation_pages=209-16; citation_id=CR7\ncitation_journal_title=Exp Cell Res.; citation_title=In situ demonstration of mycoplasma contamination in cell culture by fluorescent Hoechst 33258 stain; citation_author=TR. Chen; citation_volume=104; citation_publication_date=1977; citation_pages=255-62; citation_id=CR8\ncitation_title=Culture of animal cells: a manual of basic technique; citation_publication_date=1987; citation_id=CR9; citation_author=RI. Freshney; citation_publisher=John Wiley and Sons\ncitation_journal_title=J Pharmacol Exp Ther.; citation_title=The mycotoxin ochratoxin-A impairs protein uptake in cells derived from the proximal tubule of the kidney (opossum kidney cells); citation_author=M Gekle, S Mildenberger, R Freudinger, S. 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The toxicity of so formed acrolein involves oxidative stress, as (1) strains deficient in antioxidant defense are hypersensitive to allyl alcohol, (2) exposure to allyl alcohol increases the level of thiobarbituric-acid-reactive substances and decreases glutathione level in the cells, (3) hypoxic and anoxic atmosphere and antioxidants protect against allyl alcohol toxicity, and (4) allyl alcohol causes activation of Yap1p. No increased formation of reactive oxygen species was detected in cells exposed to allyl alcohol, so oxidative stress is due to depletion of cellular thiols and thus alteration in the redox state of yeast cells.",{"EN":2261},"Acrolein toxicity involves oxidative stress caused by glutathione depletion in the yeast Saccharomyces cerevisiae",{"VOID":2263},"Azevedo D, Tacnet F, Delaunay A, Rodrigues-Pousada C, Toledano MB. Two redox centers within Yap1 for H2O2 and thiol-reactive chemicals signaling. Free Radic Biol Med 2003;35:889–902.\nBakker BM, Bro C, Kotter P, Luttik MA, van Dijken JP, Pronk JT. The mitochondrial alcohol dehydrogenase ADH3p is involved in a redox shuttle in Saccharomyces cerevisiae. J Bacteriol 2000;182:4730–7.\nBenov L, Sztejnberg L, Fridovich I. Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical. Free Radic Biol Med 1998;25:826–31.\nBilinski T, Lukaszkiewicz J, Sledziewski A. Demonstration of anaerobic catalase synthesis in the cz1 mutant of Saccharomyces cerevisiae. Biochem Biophys Res Commun 1978;83:1225–33.\nBilinski T, Litwinska J, Blaszczynski M, Bajus A. Superoxide dismutase deficiency and the toxicity of the products of autooxidation of polyunsaturated fatty acids in yeast. Biochim Biophys Acta 1989;1001:102–6.\nBiliński T, Kwolek M, Sas E, Krynicka M, Koziol S, Owsiak-Teleon A, et al. A novel test for identifying genes involved in aldehyde detoxification in the yeast. Increased sensitivity of superoxide-deficient yeast to aldehydes and their metabolic precursors. Biofactors 2005;24:59–65.\nDelaunay A, Pflieger D, Barrault M, Vinh J, Toledano MB. A thiol peroxidase is an H2O2 receptor and redox-transducer in gene activation. Cell 2002;111:471–81.\nDrakulic T, Temple MD, Guido R, Jarolim S, Breitenbach M, Attfield PV, et al. Involvement of oxidative stress response genes in redox homeostasis, the level of reactive oxygen species, and ageing in Saccharomyces cerevisiae. FEMS Yeast Res 2005;5:1215–28.\nEnoiu M, Herber R, Wennig R, Marson C, Bodaud H, Leroy P, et al. gamma-Glutamyltranspeptidase-dependent metabolism of 4-hydroxynonenal-glutathione conjugate. Arch Biochem Biophys 2002;397:18–27.\nEsterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991;11:81–128.\nFalcon-Perez JM, Mazon MJ, Molano J, Eraso P. Functional domain analysis of yeast ABC transporter Ycf1p by site-directed mutagenesis. J Biol Chem 1999;274:23584–90.\nGrant CM. Role of the glutathione\u002Fglutaredoxin and thioredoxin systems in yeast growth and response to stress conditions. Mol Microbiol 2001;39:533–41.\nHowlett NG, Avery SV. Induction of lipid peroxidation during heavy metal stress in Saccharomyces cerevisiae and influence of plasma membrane fatty acid unsaturation. Appl Environ Microbiol 1997;63:2971–6.\nIkner A, Shiozaki K. Yeast signaling pathways in the oxidative stress response. Mutation Res 2005;569:13–27.\nIzawa S, Maeda K, Sugiyama K, Mano J, Inoue Y. Thioredoxin deficiency causes the constitutive activation of Yap1, an AP-1-like transcription factor in Saccharomyces cerevisiae. J Biol Chem 1999;274:28459–65.\nKoziol S, Zagulski M, Bilinski T, Bartosz G. Antioxidants protect the yeast Saccharomyces cerevisiae against hypertonic stress. Free Radic Res 2005;39:365–71.\nKuge S, Jones N, Nomoto A. Regulation of yAP-1 nuclear localization in response to oxidative stress. EMBO J 1997;16:1710–20.\nKuhry JG, Fonteneau P, Duportail G, Maechling C, Laustriat G. TMA-DPH: a suitable fluorescence polarization probe for specific plasma membrane fluidity studies in intact living cells. Cell Biophys 1983;5:129–40.\nLemar KM, Passa O, Aon MA, Cortassa S, Műller CT, Plummer S, et al. Allyl alcohol and garlic (Allium sativum) extract produce oxidative stress in Candida albicans. Microbiology 2005;151:3257–65.\nLeskovac V, Trivic S, Anderson BM. Use of competitive dead-end inhibitors to determine the chemical mechanism of action of yeast alcohol dehydrogenase. Mol Cell Biochem 1998;178:219–27.\nLeskovac V, Trivic S, Pericin D. The three zinc-containing alcohol dehydrogenases from baker’s yeast, Saccharomyces cerevisiae. FEMS Yeast Res 2002;2:481–94.\nLi ZS, Szczypka M, Lu YP, Thiele DJ, Rea PA. The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump. J Biol Chem 1996;271:6509–17.\nLópez-Mirabal HR, Thorsen M, Kielland-Brandt Morten C, Toledano MB, Winther JR. Cytoplasmic glutathione redox status determines survival upon exposure to the thiol-oxidant 4,4¢-dipyridyl disulfide. FEMS Yeast Res 2007;7:391–403.\nNair S, Singh SV, Krishan A. Flow cytometric monitoring of glutathione content and anthracycline retention in tumor cells. Cytometry 1991;12:336–42.\nOkazaki S, Naganuma A, Kuge S. Peroxiredoxin-mediated redox regulation of the nuclear localization of Yap1, a transcription factor in budding yeast. Antioxid Redox Signal 2005;7:327–34.\nPenninckx MJ. An overview on glutathione in Saccharomyces versus non-conventional yeasts. FEMS Yeast Res 2002;2:295–305.\nRice-Evans CA, Diplock AT, Symons MCR. Techniques in free radical research. Amsterdam: Elsevier; 1991.\nTrotter EW, Collinson EJ, Dawes IW, Grant CM. Old yellow enzymes protect against acrolein toxicity in the yeast Saccharomyces cerevisiae. Appl Environ Microbiol 2006;72:4885–92.\nTurton HE, Dawes IW, Grant CM. Saccharomyces cerevisiae exhibits a yAP-1-mediated adaptive response to malondialdehyde. J Bacteriol 1997;179:1096–101.\nUchida K, Kanematsu M, Morimitsu Y, Osawa T, Noguchi N, Niki E. Acrolein is a product of lipid peroxidation reaction. Formation of free acrolein and its conjugate with lysine residueas in oxidized low density lipoproteins. J Biol Chem 1998a;273:16058–66.\nUchida K, Kanematsu M, Sakai K, Matsuda T, Hattori N, Mizuno Y, et al. Protein-bound acrolein: Potential markers for oxidative stress. Proc Natl Acad Sci USA 1998b;95:4882–7.\nWills C, Hom D. An efficient selection producing structural gene mutants of yeast alcohol dehydrogenase resistant to pyrazole. Genetics 1988;119:791–5.\nWills C, Phelps J. Functional mutants of yeast alcohol dehydrogenase affecting kinetics, cellular redox balance and electrophoretic mobility. Biochem Genet 1978;16:415–32.\nYang M, Schaich KM. Factors affecting DNA damage caused by lipid hydroperoxides and aldehydes. Free Radic Biol Med 1996;20:225–36.",{"VOID":2265},"10.1007\u002Fs10565-008-9090-x","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs10565-008-9090-x",[2268,2283,2296,2318],{"id":2269,"sortIndex":32,"researcher":28,"roles":2270,"affiliations":2271,"properties":2280,"displayName":2282,"givenName":28,"familyName":28},"115510d5-b2a8-4570-aa56-ab48dea24a1b",[1018],[2272],{"id":2273,"sortIndex":32,"affiliation":2274,"properties":28},"3aa95062-cdf1-4d11-9f91-24e70d92f3c4",{"id":2273,"createTime":28,"updateTime":28,"relativeEntities":2275,"slug":28,"properties":2276,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":2279,"statistic":28},[],{"title":2277},{"VI":2278},"Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszów, Poland",[],{"title":2281},{"VI":2282},"M. 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Serotonin type-3 (5-HT3) receptor antagonists, such as tropisetron and ondansetron, are well-tolerated antiemetic drugs commonly used to prevent nausea caused by chemotherapy or radiotherapy. We investigated the anticancer effects of these drugs on melanoma cancer cell lines WM-266–4 and B16F10 with or without paclitaxel. We constructed IC50 curves and performed Chou–Talalay analysis, using data obtained with the MTT assay. Flow cytometry and fluorescent microscopy were used to examine characteristics of the cell cycle, cell death and cytoskeleton changes. Protein levels and activation were analysed by western blotting and molecular docking studies carried out. Data were analysed by one way ANOVA and post hoc testing. Ondansetron and tropisetron showed selective concentration-dependent cytotoxicity in melanoma cell lines WM-266–4 and B16F10. The effect in combination with paclitaxel was synergistic. The drugs did not cause cell cycle arrest but did promote characteristics of classical apoptosis, including accumulation of subG1 DNA, cleaved caspase-3, mitochondrial membrane permeability and phosphatidylserine exposure. As well, the cytosolic calcium level in the melanoma cells was enhanced, phosphorylated ERK1\u002F2 induced and NF-κB inhibited. Finally, the formation of microtubules was shown to be impaired in melanoma cells treated with ondansetron or tropisetron. Docking studies were used to predict that these drugs could bind to the colchicine binding site on the tubulin molecule. Antiemetic drugs, already given in combination with chemotherapy, may enhance the cytotoxic effect of chemotherapy, following successful delivery to the tumour site.",{"EN":2400},"Serotonin type-3 receptor antagonists selectively kill melanoma cells through classical apoptosis, microtubule depolymerisation, ERK activation, and NF-κB downregulation",{"VOID":2402},"Abdel-Aziz H, Windeck T, Ploch M, Verspohl EJ. Mode of action of gingerols and shogoals on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isloated guinea-pig ileum. Eur J Pharmacol. 2006;530(1–2):136–43.\nAtaee R, Ajdary S, Zarrindast M, Rezayat M, Shokrgozar MA, Ataee A. Y25130 hydrochloride, a selective 5HT3 receptor antagonist has potent antimitogenic and apoptotic effect on HT29 colorectal cancer cell line. Euro J Can Prev. 2010;19:138–43.\nBaldwin AS. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB. J Clin Invest. 2001;107:241–6.\nBane S. A fluorescence-based high-throughput assay for antimicrotubule drugs. Analytical Biochem. 2003;315:49–56.\nBarzegar-Fallah A, Alimoradi H, Mehrzadi S, Barzegar-Fallah N, Zendedel A, Abbasi A, et al. The neuroprotective effect of tropisetron on vincristine-induced neurotoxicity. Neurotoxicol. 2014;41:1–8.\nBower KS, Price KL, Sturdee LEC, Dayrell M, Dougherty DA, Lummis SCR. 5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function. Eur J Pharmacol. 2008;580(3):291–7.\nBrand MD, Nicholls DG. Assessing mitochondrial dysfunction in cells. Biochem J. 2011;435:297–312.\nChen J, Li CM, Wang J, Ahn S, Wang Z, Lu Y, et al. Synthesis and antiproliferative activity of novel 2-aryl-4-benzoyl-imidazole derivatives targeting tubulin polymerization. Bioorg Med Chem. 2011;19:4782–95.\nChou TC. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res. 2010;70:440–6.\nCummins DL, Cummins JM, Pantle H, Silverman MA, Leonard AL, Chanmugam A. Cutaneous malignant melanoma. Mayo Clin Proc. 2006;81(4):500–7.\nDe La Vega L, Muñoz E, Calzado MA, Lieb K, Candelario-Jalil KE, Gschaidmeir H, et al. The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway. Biochem Pharmacol. 2005;70:369–80.\nDuan L, Danzer B, Levenson VV, Maki CG. Critical roles for nitric oxide and ERK in the completion of prosurvival autophagy in 4OHTAM-treated estrogen receptor-positive breast cancer cells. Cancer Lett. 2014;353:290–300.\nDuan YT, Man RJ, Tang DJ, Yao YF, Tao XX, C. Yu C, , et al. Design, synthesis and antitumor activity of novel link-bridge and B-ring modified combretastatin A-4 (CA-4) analogues as potent antitubulin agents. Sci Rep. 2016;6:25387.\nFadok V, Voelker D, Campbell P, Cohen J, Bratton D, Henson P. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol. 1992;148:2207–16.\nFarkas DL, Wei M, Febbroriello P, Carson J, Loew L. Simultaneous imaging of cell and mitochondrial membrane potentials. Biophys J. 1989;56:1053–69.\nGogas HJ, Kirkwood JM, Sondak VK. Chemotherapy for metastatic melanoma: time for a change? Cancer. 2007;109:455–64.\nGray-Schopfer V, Wellbrock C, Marais R. Melanoma biology and new targeted therapy. Nature. 2007;445:851–7.\nGrynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem. 1985;260:3440–50.\nHanwell MD, Curtis DE, Lonie DC, Vandermeersch T, Zurek E, Hutchison GR. Avogadro: an advanced semantic chemical editor, visualization, and analysis platform. J Cheminformatics. 2012;4:17.\nHaus U, Späth M, Färber L. Spectrum of use and tolerability of 5-HT3 receptor antagonists. Scand J Rheumatol. 2004;33:12–8.\nHejazi SH, Ahangari G, Deezagi A. Alternative viewpoint against breast cancer based on selective serotonin receptors 5HTR3A and 5HTR2A antagonists that can mediate apoptosis in MCF-7 cell line. Current Drug Discovery Technol. 2015;12:240–9.\nHimes RH. Interactions of the catharanthus (Vinca) alkaloids with tubulin and microtubules. Pharmacol Ther. 1991;51:257–67.\nIchas F, Mazat JP. From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low-to high-conductance state. Biochim Biophys Acta Bioenergetics. 1998;1366:33–50.\nJackman RW, Rhoads MG, Cornwell E, Kandarian SC. Microtubule-mediated NF-kB activation in the TNF-a signling pathway. Exp Cell Res. 2009;315:3242–9.\nJones G, Willett P, Glen RC. Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation. J Mol Biol. 1995;245:43–53.\nJones G, Willett P, Glen RC, Leach AR, Taylor R. Development and validation of a genetic algorithm for flexible docking. J Mol Biol. 1997;267:727–48.\nKarin M, Cao Y, Greten FR, Li ZW. NF-κB in cancer: from innocent bystander to major culprit. Nat Rev Can. 2002;2(4):301–10.\nKrishan A. Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J Cell Biol. 1975;66:188–93.\nLa Regina G, Bai R, Coluccia A, Naccarato V, Famiglini V, Nalli M, et al. New 6-and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors. Euro J Med Chem. 2018;152:283–97.\nLoew LM, Carrington W, Tuft RA, Fay FS. Physiological cytosolic Ca2+ transients evoke concurrent mitochondrial depolarizations. PNAS. 1994;91:12579–83.\nMebratu Y, Tesfaigzi Y. How ERK1\u002F2 activation controls cell proliferation and cell death: is subcellular localization the answer? Cell Cycle. 2009;8:1168–75.\nMolgaard S, Ulrichsen M, Olsen D, Glerup S. Detection of phosphorylated Akt and MAPK in cell culture assays. MethodsX. 2016;3:386–98.\nMosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65:55–63.\nRello-Varona S, Herrero-Martín D, López-Alemany R, Muñoz-Pinedo C, Tirado OM. “(Not) all (dead) things share the same breath”: identification of cell death mechanisms in anticancer therapy. Cancer Res. 2015;75:913–7.\nRoe M, Lemasters J, Herman B. Assessment of Fura-2 for measurements of cytosolic free calcium. Cell Calcium. 1990;11:63–73.\nSouphron J, Bodakuntla S, Jijumon AS, Lakisic G, Gautreau AM, Janke C, Magiera MM. Purification of tubulin with controlled post-translational modiciations by polymerization-depolymierization cycles. Nat Prot. 2019;14:1634–60.\nStratz T, Müller W. The use of 5-HT3 receptor antagonists in various rheumatic diseases - a clue to the mechanism of action of these agents in fibromyalgia? Scand J Rheumatol. 2000;29:66–71.\nTang D, Wu D, Hirao A, Lahti JM, Liu L, Mazza B, et al. ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J Biol Chem. 2002;277:12710–7.\nTanimura S, Uchiyama A, Watanabe K, Yasunaga M, Inada Y, Kawabata T, Iwashita K, Noda S, Ozaki K, Kohno M. Blockade of constitutively activated ERK signaling enhances cytotoxicity of microtubule-destabilising agents in tumor cells. Biochem Biophys Res Communs. 2009;378:650–5.\nTien S-C, Chang Z-F. Oncogenic Shp2 disturbs microtubule regulation to cause HDAC6-dependent ERK hyperactivation. Oncogene. 2014;33:2938–46.\nVermes I, Haanen C, Steffens-Nakken H, Reutellingsperger C. A novel assay for apoptosis flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V. J Immunol Methods. 1995;184:39–51.\nWahl AF, Donaldson KL, Fairchild C, Lee FY, Foster SA, Demers GW, Galloway DA. Loss of normal p53 function confers sensitization to Taxol by increasing G2\u002FM arrest and apoptosis. Nat Med. 1996;2(1):72–9.\nWang Y, Zhang H, Gigant B, Yu Y, Wu Y, Chen X, et al. Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery. FEBS J. 2016;283:102–11.\nWolf H. Preclinical and clinical pharmacology of the 5-HT3 receptor antagonists. Scand J Rheumatol. 2000;29:37–45.\nZhao Y, Su J, Goto M, Morris-Natschke SL, Li Y, Zhao QS, Yao ZJ, Lee KH. Dual-functional abeo-taxane derivatives destablising microtubule equilibrium and inhibiting NF-kB activation. J Med Chem. 2013;56:4749–57.\nZhong FJ, Li YM, Xu C, Sun B, Wang JL, Yang LY. EB2 promotes hepatocellular carcinoma proliferation and metastasis via MAPK\u002FERK pathway by modulating microtubule dynamics. 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