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10.1038\u002Fbjc.1991.210\nSim, 2005, Changing demography of prostate cancer in Asia, Eur J Cancer, 41, 834, 10.1016\u002Fj.ejca.2004.12.033\nMagee, 2004, Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer, Br J Nutr, 91, 513, 10.1079\u002FBJN20031075\nMessina, 2003, Emerging evidence on the role of soy in reducing prostate cancer risk, Nutr Rev, 61, 117, 10.1301\u002Fnr.2003.apr.117-131\nMessina, 2006, An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels, J AOAC Int, 89, 1121, 10.1093\u002Fjaoac\u002F89.4.1121\nNakamura, 2000, Determination of the levels of isoflavonoids in soybeans and soy-derived foods and estimation of isoflavonoids in the Japanese daily intake, J AOAC Int, 83, 635, 10.1093\u002Fjaoac\u002F83.3.635\nSteiner, 2008, Isoflavones and the prevention of breast and prostate cancer: new perspectives opened by nutrigenomics, Br J Nutr, 99, ES78, 10.1017\u002FS0007114508965788\nPollard, 2006, Dietary prevention of hormone refractory prostate cancer in Lobund-Wistar rats: a review of studies in a relevant animal model, Comp Med, 56, 461\nWang, 2002, Dietary genistein suppresses chemically induced prostate cancer in Lobund-Wistar rats, Cancer Lett, 186, 11, 10.1016\u002FS0304-3835(01)00811-4\nHedlund, 2003, Soy isoflavonoid equol modulates the growth of benign and malignant prostatic epithelial cells in vitro, Prostate, 54, 68, 10.1002\u002Fpros.10137\nFang, 2005, Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy, Clin Cancer Res, 11, 7033, 10.1158\u002F1078-0432.CCR-05-0406\nLi, 2005, Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells, Cancer Res, 65, 6934, 10.1158\u002F0008-5472.CAN-04-4604\nBarnes, 1995, Biochemical targets of the isoflavone genistein in tumor cell lines, Proc Soc Exp Biol Med, 208, 103, 10.3181\u002F00379727-208-43840\nSatih, 2008, Soy phytoestrogens and breast cancer chemoprevention: molecular mechanisms, Curr Nutr Food Sci, 4, 259, 10.2174\u002F157340108786263658\nFotsis, 1993, Genistein, a dietary-derived inhibitor of in vitro angiogenesis, Proc Natl Acad Sci USA, 90, 2690, 10.1073\u002Fpnas.90.7.2690\nFotsis, 1995, Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis, J Nutr, 125, 790S\nKrishan, 1975, Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining, J Cell Biol, 66, 188, 10.1083\u002Fjcb.66.1.188\nFavy, 2000, Real-time PCR quantification of full-length and exon 11 spliced BRCA1 transcripts in human breast cancer cell lines, Biochem Biophys Res Commun, 274, 73, 10.1006\u002Fbbrc.2000.3100\nOki, 2004, Genistein induces Gadd45 gene and G2\u002FM cell cycle arrest in the DU145 human prostate cancer cell line, FEBS Lett, 577, 55, 10.1016\u002Fj.febslet.2004.09.085\nShenouda, 2004, Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro, Nutr Cancer, 49, 200, 10.1207\u002Fs15327914nc4902_12\nKobayashi, 2002, Effect of flavonoids on cell cycle progression in prostate cancer cells, Cancer Lett, 176, 17, 10.1016\u002FS0304-3835(01)00738-8\nel-Deiry, 1993, WAF1, a potential mediator of p53 tumor suppression, Cell, 75, 817, 10.1016\u002F0092-8674(93)90500-P\nGartel, 2002, The role of the cyclin-dependent kinase inhibitor p21 in apoptosis, Mol Cancer Ther, 1, 639\nHandayani, 2006, Soy isoflavones alter expression of genes associated with cancer progression, including interleukin-8, in androgen-independent PC-3 human prostate cancer cells, J Nutr, 136, 75, 10.1093\u002Fjn\u002F136.1.75\nKaran, 2002, Expression profile of differentially-regulated genes during progression of androgen-independent growth in human prostate cancer cells, Carcinogenesis, 23, 967, 10.1093\u002Fcarcin\u002F23.6.967\nKo, 1997, p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner, Mol Cell Biol, 17, 7220, 10.1128\u002FMCB.17.12.7220\nPadmanabhan, 2004, DNA replication regulation protein Mcm7 as a marker of proliferation in prostate cancer, J Clin Pathol, 57, 1057, 10.1136\u002Fjcp.2004.016436\nTakisawa, 2000, Eukaryotic DNA replication: from pre-replication complex to initiation complex, Curr Opin Cell Biol, 12, 690, 10.1016\u002FS0955-0674(00)00153-8\nBerner, 1995, TP53 mutations in prostatic cancer. 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Public Health, 39, 12, 10.1177\u002F1403494811399956\n2012\nQuan, 2011, Updating and validating the charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries, Am. J. Epidemiol., 173, 676, 10.1093\u002Faje\u002Fkwq433\nLynge, 2011, The Danish national patient register, Scand. J. Public Health, 39, 30, 10.1177\u002F1403494811401482\nCasetta, 2017, Association between cigarette smoking prevalence and income level: a systematic review and meta-analysis, Nicotine Tob. Res., 40\nNg, 2017, The relationship between drinking pattern, social Capital, and Area-deprivation: findings from the health survey for England, J. Stud. Alcohol Drugs, 78, 20, 10.15288\u002Fjsad.2017.78.20\nWilchesky, 2004, Validation of diagnostic codes within medical services claims, J. Clin. 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Prev., 16, 1260, 10.1158\u002F1055-9965.EPI-07-0038\nFarnsworth, 1999, Prostate stroma: physiology, Prostate, 38, 60, 10.1002\u002F(SICI)1097-0045(19990101)38:1\u003C60::AID-PROS8>3.0.CO;2-3\nFerreira, 2013, Summary of the recommendations of the EFNS\u002FMDS-ES review on therapeutic management of Parkinson’s disease, Eur. J. Neurol., 20, 5, 10.1111\u002Fj.1468-1331.2012.03866.x\nGjerstorff, 2011, The Danish Cancer Registry, Scand. J. Public Health, 39, 42, 10.1177\u002F1403494810393562\nHernan, 2002, A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson’s disease, Ann. Neurol., 52, 276, 10.1002\u002Fana.10277\nLynge, 2011, The Danish National Patient Register, Scand. J. Public Health, 39, 30, 10.1177\u002F1403494811401482\nMagnon, 2013, Autonomic nerve development contributes to prostate cancer progression, Science (New York, N.Y.), 341, 1236361, 10.1126\u002Fscience.1236361\nMaru, 2001, Prognostic significance of the diameter of perineural invasion in radical prostatectomy specimens, Hum. Pathol., 32, 828, 10.1053\u002Fhupa.2001.26456\nMcVary, 1994, Growth of the rat prostate gland is facilitated by the autonomic nervous system, Biol. Reprod., 51, 99, 10.1095\u002Fbiolreprod51.1.99\nOlsen, 2005, Atypical cancer pattern in patients with Parkinson’s disease, Br. J. Cancer, 92, 201, 10.1038\u002Fsj.bjc.6602279\nOutzen, 2012, Prostate cancer in Denmark 1978–2009 – trends in incidence and mortality, Acta Oncol. (Stockholm, Sweden), 52, 831, 10.3109\u002F0284186X.2012.702922\nPedersen, 2011, The Danish Civil Registration System, Scand. J. 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J. Epidemiol., 44, 186, 10.1093\u002Fije\u002Fdyu240\nHowlader, 2008\nWahi, 2009, Reproductive factors and risk of pancreatic cancer in women: a review of the literature, Ann. Epidemiol., 19, 103, 10.1016\u002Fj.annepidem.2008.11.003\nAndren-Sandberg, 1999, Other risk factors for pancreatic cancer: hormonal aspects, Ann. Oncol., 10, 131, 10.1093\u002Fannonc\u002F10.suppl_4.S131\nRobles-Diaz, 2001, Pancreas: a sex steroid-dependent tissue, IMAJ, 3, 364\nSkinner, 2003, Parity, reproductive factors, and the risk of pancreatic cancer in women, Cancer Epidemiol. Biomarkers Prev., 12, 433\nNavarro Silvera, 2005, Hormonal and reproductive factors and pancreatic cancer risk: a prospective cohort study, Pancreas, 30, 369, 10.1097\u002F01.mpa.0000160301.59319.ba\nTeras, 2005, Parity, other reproductive factors, and risk of pancreatic cancer mortality in a large cohort of U.S. women (United States), Cancer Causes Control, 16, 1035, 10.1007\u002Fs10552-005-0332-4\nLin, 2006, Association of menstrual and reproductive factors with pancreatic cancer risk in women: findings of the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk, J. Gastroenterol., 41, 878, 10.1007\u002Fs00535-006-1869-z\nPrizment, 2007, Pancreatic cancer incidence in relation to female reproductive factors: the Iowa Women’s Health Study, J. Pancreas, 8, 16\nLo, 2007, Lifestyle, occupation, and reproductive factors in relation to pancreatic cancer risk, Pancreas, 35, 120, 10.1097\u002Fmpa.0b013e318053e7d3\nHuech, 2008, Reproductive factors and pancreatic cancer risk: a Norwegian cohort study, Br. J. Cancer, 98, 189, 10.1038\u002Fsj.bjc.6604095\nDuell, 2009, Menstrual and reproductive factors and pancreatic cancer in the SEARCH program of IARC, Cancer Causes Control, 20, 1757, 10.1007\u002Fs10552-009-9408-x\nStevens, 2009, Reproductive history and pancreatic cancer incidence and mortality in a cohort of postmenopausal women, Cancer Epidemiol. Biomarkers Prev., 18, 1457, 10.1158\u002F1055-9965.EPI-08-1134\nZhang, 2010, A case-control study of reproductive factors, female hormone use, and risk of pancreatic cancer, Cancer Causes Control, 21, 473, 10.1007\u002Fs10552-009-9478-9\nChang, 2010, Parity, age at first birth, and risk of death from pancreatic cancer: evidence from a cohort in Taiwan, Pancreas, 39, 567, 10.1097\u002FMPA.0b013e3181c7341e\nDuell, 2013, Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort, Int. J. Cancer, 132, 2164, 10.1002\u002Fijc.27875\nLee, 2013, Reproductive factors, exogenous hormones, and pancreatic cancer risk in the CTS, Am. J. Epidemiol., 178, 1403, 10.1093\u002Faje\u002Fkwt154\nLujan-Barroso, 2016, Menstrual and reproductive factors, hormone use, and risk of pancreatic cancer: analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4), Pancreas, 45, 1401, 10.1097\u002FMPA.0000000000000635\nWomen’s Health Initiative Study Group, 1998, Design of the Women’s Health Initiative clinical trial and observational study, Control Clin. Trials, 19, 61, 10.1016\u002FS0197-2456(97)00078-0\nLanger, 2003, The Women’s Health Initiative Observational Study: baseline characteristics of participants and reliability of baseline measure, Ann. Epidemiol., 13, S107, 10.1016\u002FS1047-2797(03)00047-4\nLuo, 2013, Diabetes mellitus as a risk factor for gastrointestinal cancers among postmenopausal women, Cancer Causes Control, 24, 577, 10.1007\u002Fs10552-012-9996-8\nCurb, 2003, WHI morbidity and mortality committee, outcomes ascertainment and adjudication methods in the women’s health initiative, Ann. Epidemiol., 13, S122, 10.1016\u002FS1047-2797(03)00048-6\nZhu, 2014, Parity and pancreatic cancer risk: evidence from a meta-analysis of twenty epidemiologic studies, Sci. 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Barrett esophagus and esophageal adenocarcinoma, Dis Esophagus, 19, 321, 10.1111\u002Fj.1442-2050.2006.00602.x\nChow, 1998, Body mass index and risk of adenocarcinomas of the esophagus and gastric cardia, J Natl Cancer Inst, 90, 150, 10.1093\u002Fjnci\u002F90.2.150\nLagergren, 1999, Association between body mass and adenocarcinoma of the esophagus and gastric cardia, Ann Intern Med, 130, 883, 10.7326\u002F0003-4819-130-11-199906010-00003\nWu, 2001, A multiethnic population-based study of smoking, alcohol and body size and risk of adenocarcinomas of the stomach and esophagus (United States), Cancer Causes Control, 12, 721, 10.1023\u002FA:1011290704728\nMayne, 2002, Diet, obesity and reflux in the etiology of adenocarcinomas of the esophagus and gastric cardia in humans, J Nutr, 132, 3467, 10.1093\u002Fjn\u002F132.11.3467S\nCorley, 2008, Abdominal obesity and the risk of esophageal and gastric cardia carcinomas, Cancer Epidemiol Biomarkers Prev, 17, 352, 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signalling in cancer, Br J Cancer, 92, 2097, 10.1038\u002Fsj.bjc.6602627\nSamani, 2007, The role of the IGF system in cancer growth and metastasis: overview and recent insights, Endocr Rev, 28, 20, 10.1210\u002Fer.2006-0001\nBaur, 2006, Resveratrol improves health and survival of mice on a high-calorie diet, Nature, 444, 337, 10.1038\u002Fnature05354\nWolf, 2005, Diabetes mellitus and breast cancer, Lancet Oncol, 6, 103, 10.1016\u002FS1470-2045(05)01736-5\nEl-Serag, 2006, The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence, Clin Gastroenterol Hepatol, 4, 369, 10.1016\u002Fj.cgh.2005.12.007\nRochester, 2007, The type 1 insulin-like growth factor receptor is over-expressed in bladder cancer, BJU Int, 100, 1396, 10.1111\u002Fj.1464-410X.2007.06931.x\nHudelist, 2007, Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1\u002F2 mutations, Endocr Relat Cancer, 14, 1053, 10.1677\u002FERC-06-0075\nWeber, 2002, Overexpression of the insulin-like growth factor I receptor in human colon carcinomas, Cancer, 95, 2086, 10.1002\u002Fcncr.10945\nBarnard, 1995, Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology, Gastroenterology, 108, 564, 10.1016\u002F0016-5085(95)90087-X\nQureshi, 1997, EGF and IGF-I synergistically stimulate proliferation of human esophageal epithelial cells, J Surg Res, 69, 354, 10.1006\u002Fjsre.1997.5080\nBonafe, 2003, Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control, J Clin Endocrinol Metab, 88, 3299, 10.1210\u002Fjc.2002-021810\nCasson, 2005, Cyclin D1 polymorphism (G870A) and risk for esophageal adenocarcinoma, Cancer, 104, 730, 10.1002\u002Fcncr.21229\nCasson, 2005, Polymorphisms in DNA repair genes in the molecular pathogenesis of esophageal (Barrett) adenocarcinoma, Carcinogenesis, 26, 1536, 10.1093\u002Fcarcin\u002Fbgi115\nBalogh, 2006, Lack of association between insulin-like growth factor I receptor G(+3174)A polymorphism and retinopathy of prematurity, Graefes Arch Clin Exp Ophthalmol, 244, 1035, 10.1007\u002Fs00417-005-0203-4\nRasmussen, 2000, Studies of the variability of the genes encoding the insulin-like growth factor I receptor and its ligand in relation to type 2 diabetes mellitus, J Clin Endocrinol Metab, 85, 1606, 10.1210\u002Fjc.85.4.1606\nDoecke, 2008, Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers, Cancer Epidemiol Biomarkers Prev, 17, 1007, 10.1158\u002F1055-9965.EPI-08-0023\nGram, 2006, Body mass index, waist circumference and waist-hip ratio and serum levels of IGF-I and IGFBP-3 in European women, Int J Obes (Lond), 30, 1623, 10.1038\u002Fsj.ijo.0803324\nGunter, 2008, A prospective evaluation of insulin and insulin-like growth 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