[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_69ee636b-2246-4c0c-ad16-e45c1de27815":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:69ee636b-2246-4c0c-ad16-e45c1de27815,\"}":125},{"code":4,"data":5,"meta":24},"SUCCESS",{"id":6,"createTime":7,"updateTime":8,"relativeEntities":9,"slug":10,"properties":11,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":26,"manageAffiliations":59,"indexDatabases":81,"url":124,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},"69ee636b-2246-4c0c-ad16-e45c1de27815","2023-05-29T11:00:33.620+00:00","2025-11-21T10:02:55.277+00:00",[],"Canadian-Journal-of-Physiology-and-Pharmacology",{"country":12,"issn":14,"introduce":16,"eissn":18,"title":20},{"VOID":13},"CA",{"VOID":15},"00084212",{"EN":17},"Published since 1929, this monthly journal reports current research in all aspects of physiology, nutrition, pharmacology, and toxicology, contributed by recognized experts and scientists. It publishes symposium reviews and award lectures and occasionally dedicates entire issues or portions of issues to subjects of special interest to its international readership. The journal periodically publishes a “Made In Canada” special section that features invited review articles from internationally recognized scientists who have received some of their training in Canada. Although the Scope of the Journal is broad, the Canadian Journal of Physiology and Pharmacology does not accept papers addressing the actions of plant or other biological extracts which may contain several active molecules with potentially distinct mechanisms of action.",{"VOID":19},"12057541",{"EN":21},"Canadian Journal of Physiology and Pharmacology","PUBLISHER","PENDING",null,0,[27,35,43,51],{"id":28,"createTime":29,"updateTime":30,"relativeEntities":31,"label":32,"description":34,"parentId":24,"standard":24,"scholarHubFieldId":24},"317b242e-4e36-43ab-821e-f9755e22375e","2023-05-29T10:24:14.083+00:00","2023-11-21T05:26:08.510+00:00",[],{"EN":33},"Physiology",{},{"id":36,"createTime":37,"updateTime":38,"relativeEntities":39,"label":40,"description":42,"parentId":24,"standard":24,"scholarHubFieldId":24},"c3a687ae-b679-4131-bf6c-8a4d1beb2acb","2023-05-29T10:24:14.109+00:00","2023-11-21T05:26:08.496+00:00",[],{"EN":41},"Physiology (medical)",{},{"id":44,"createTime":45,"updateTime":46,"relativeEntities":47,"label":48,"description":50,"parentId":24,"standard":24,"scholarHubFieldId":24},"0254e3e5-c28d-4a33-83da-81bc94d29ffd","2023-05-29T10:24:00.931+00:00","2023-11-21T07:56:41.438+00:00",[],{"EN":49},"Medicine (miscellaneous)",{},{"id":52,"createTime":53,"updateTime":54,"relativeEntities":55,"label":56,"description":58,"parentId":24,"standard":24,"scholarHubFieldId":24},"8b51d244-613f-4ff9-b308-d32de7c33ed9","2023-05-29T10:24:08.511+00:00","2023-11-21T07:37:03.796+00:00",[],{"EN":57},"Pharmacology",{},[60,71],{"id":61,"createTime":62,"updateTime":63,"relativeEntities":64,"slug":65,"properties":66,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"url":24,"parentIds":70,"statistic":24},"c2758834-c1b0-4ac7-a2d2-e5e9c2ce9b03","2023-05-29T10:25:42.483+00:00","2025-11-21T09:54:49.928+00:00",[],"Canadian-Science-Publishing",{"title":67},{"EN":68},"Canadian Science Publishing","AFFILIATION",[],{"id":72,"createTime":73,"updateTime":74,"relativeEntities":75,"slug":76,"properties":77,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"url":24,"parentIds":80,"statistic":24},"3da8b37a-2bf9-4db4-8144-5b26009bb15d","2024-04-13T18:18:51.534+00:00","2025-02-11T04:17:11.225+00:00",[],"National-Research-Council-of-Canada",{"title":78},{"EN":79},"National Research Council of Canada",[],[82,104],{"id":83,"indexDatabase":84,"url":96,"indexYears":97,"academicFieldIds":98,"indexDatabaseRanking":103},"b521ad52-1a77-4185-9eb1-8872875996ab",{"id":85,"createTime":86,"updateTime":87,"relativeEntities":88,"label":89,"description":91,"key":93,"publicationTags":94,"standard":24},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9","2023-05-22T09:57:18.509+00:00","2025-11-21T10:07:52.274+00:00",[],{"EN":90,"VI":90},"Scopus - Elsevier",{"EN":90,"VI":92},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[95],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F23363","1964-2025",[99,100,101,102],"e89cebf4-fecf-4b74-8ab4-88fca891e4c2","e39d1b91-b03d-48ed-87bb-ab5b714ad558","f845e4fe-178d-4593-b013-715b3c1cc81c","6265d46a-80a6-48ce-b79a-f3a34594a0bd","SCOPUS__Q1",{"id":105,"indexDatabase":106,"url":120,"indexYears":24,"academicFieldIds":121,"indexDatabaseRanking":24},"a39b2c2e-9c95-4797-9037-8b7445c0ecf1",{"id":107,"createTime":108,"updateTime":109,"relativeEntities":110,"label":111,"description":113,"key":116,"publicationTags":117,"standard":24},"a4921856-b128-4d9f-8f1f-e80813d3bbd4","2023-05-22T09:59:31.026+00:00","2025-11-21T10:07:52.153+00:00",[],{"EN":112,"VI":112},"ISI\u002FSCIE - Science Citation Index Expanded",{"VI":114,"EN":115},"Cơ sở dữ liệu SCIE","SCIE database","scie",[118,119],"SCIE","ISI","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=0008-4212",[122,123],"2b943d65-24a8-4546-9232-a1e32c12cb6c","08b1efac-a7b2-46c7-9e79-ef24d3d9025d","https:\u002F\u002Fwww.nrcresearchpress.com\u002Floi\u002Fcjpp",{"meta":126,"data":128},{"total":127},"122",[129,237,330,763,1075,1462,1784,2147,2224,2314],{"id":130,"createTime":131,"updateTime":131,"relativeEntities":132,"slug":133,"properties":134,"entityType":148,"verifyStatus":23,"verifyTime":131,"verifyNote":149,"syncStatus":23,"languages":150,"translateLanguages":24,"viewCount":25,"primaryUrl":152,"fullTextUrl":24,"authors":153,"publicationType":196,"publisherRelationship":197,"citationCount":230,"citationInfo":231,"publishDate":233,"publishYear":234,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":235,"isForceReanalyzing":236},"7acb0090-53d5-46dc-ac25-3df1c8b4f306","2024-09-22T23:18:36.613+00:00",[],"Effects-of-gaseous-anesthetics-and-ultrashort-and-short-acting-barbiturates-on-human-blood-platelet-free-cytosolic-calcium-relevance-to-their-effects-on-platelet-aggregation",{"mag":135,"keywords":137,"openalex":138,"abstract":140,"title":142,"pm":144,"doi":146},{"VOID":136},"2062613255",{},{"VOID":139},"W2062613255",{"EN":141},"\u003Cjats:p> The effects of elevated pressures (to 6 atmospheres absolute (ATA)) of nitrous oxide (N\u003Cjats:sub>2\u003C\u002Fjats:sub>O) and of xenon (Xe), and barbiturates on platelet free cytosolic calcium ([Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup>]\u003Cjats:sub>i\u003C\u002Fjats:sub>) and platelet aggregation were studied. N\u003Cjats:sub>2\u003C\u002Fjats:sub>O inhibited the ADP-induced rise in [Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup>]\u003Cjats:sub>i\u003C\u002Fjats:sub> whereas Xe had no effect. Neither affected basal levels. Pentobarbital and methohexital had little effect on basal or stimulated levels in the presence or \"absence\" of extracellular Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup>; but both, at concentrations > 10\u003Cjats:sup>−4\u003C\u002Fjats:sup> M, inhibited platelet aggregation induced by adenosine diphosphate. Thiopental increased basal and stimulated [Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup>]\u003Cjats:sub>i\u003C\u002Fjats:sub> when extracellular Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup> was present, but not when it was absent, and displayed a bimodal effect with low and high doses being more active than intermediate ones. It also potentiated aggregation. Methitural displayed similar, but nonsignificant, effects. These patterns held for all agents whether or not acetylsalicylic acid was present. Pentobarbital and methohexital inhibited phorbol myristate acetate aggregation in low extracellular calcium and no potentiation was seen with thiopental. In the absence of extracellular Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup>, no potentiation was observed in stimulated platelets. Potentiation of aggregation previously reported for Xe does not involve increased Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup> uptake and did not occur in the absence of extracellular Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup>. A common mechanism of action for these agents cannot be inferred from their effects on platelet aggregation or [Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup>]\u003Cjats:sub>i\u003C\u002Fjats:sub>, as their pharmacological profiles differ markedly. It is evident that their inhibitory properties in this cell are not dependent on extracellular Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup>, whereas the potentiation observed with pentobarbital, and formerly with Xe, is so dependent.Key words: platelets, aggregation, calcium, anesthetics, narcotic gases. \u003C\u002Fjats:p>",{"EN":143},"Effects of gaseous anesthetics and ultrashort and short-acting barbiturates on human blood platelet free cytosolic calcium: relevance to their effects on platelet aggregation",{"VOID":145},"1473048",{"VOID":147},"10.1139\u002Fy92-161","PUBLICATION","Author affiliation is blank",[151],"EN","http:\u002F\u002Fwww.nrcresearchpress.com\u002Fdoi\u002F10.1139\u002Fy92-161",[154,166,186],{"id":155,"sortIndex":156,"researcher":24,"roles":157,"affiliations":158,"properties":159},"21a5efdd-a1e0-4d2a-9ac1-77b733a1e419",1,[],[],{"openalex":160,"orcid":162,"title":164},{"VOID":161},"A5019379095",{"VOID":163},"https:\u002F\u002Forcid.org\u002F0000-0002-4037-7406",{"EN":165},"Pooja Arora",{"id":167,"sortIndex":25,"researcher":24,"roles":168,"affiliations":169,"properties":181},"21af4566-b1b0-4d39-8634-3d61d117dfb2",[],[170],{"id":171,"sortIndex":25,"affiliation":172,"properties":24},"a136724a-91b0-4938-8ef3-4d495c0cf427",{"id":173,"createTime":174,"updateTime":175,"relativeEntities":176,"slug":177,"properties":178,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"5f1cbc57-430f-46b3-a316-5703fd147489","2024-01-19T10:10:40.425+00:00","2024-09-22T23:18:36.625+00:00",[],"Department-of-Pharmacology-and-Toxicology-University-of-Western-Ontario-London-Canada",{"title":179},{"VI":180},"Department of Pharmacology and Toxicology, University of Western Ontario, London, Canada",{"openalex":182,"title":184},{"VOID":183},"A5086433153",{"EN":185},"Richard B. Philp",{"id":187,"sortIndex":188,"researcher":24,"roles":189,"affiliations":190,"properties":191},"f1a3beee-9435-4a76-ae36-3cc6c9f03e18",2,[],[],{"openalex":192,"title":194},{"VOID":193},"A5070965497",{"EN":195},"Donald J.L. McIver","ARTICLE",{"url":24,"publisher":198,"properties":223},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":199,"slug":10,"properties":200,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":206,"manageAffiliations":207,"indexDatabases":208,"url":124,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":201,"issn":202,"introduce":203,"eissn":204,"title":205},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[209,216],{"id":105,"indexDatabase":210,"url":120,"indexYears":24,"academicFieldIds":215,"indexDatabaseRanking":24},{"id":107,"createTime":108,"updateTime":109,"relativeEntities":211,"label":212,"description":213,"key":116,"publicationTags":214,"standard":24},[],{"EN":112,"VI":112},{"VI":114,"EN":115},[118,119],[122,123],{"id":83,"indexDatabase":217,"url":96,"indexYears":97,"academicFieldIds":222,"indexDatabaseRanking":103},{"id":85,"createTime":86,"updateTime":87,"relativeEntities":218,"label":219,"description":220,"key":93,"publicationTags":221,"standard":24},[],{"EN":90,"VI":90},{"EN":90,"VI":92},[95],[99,100,101,102],{"volume":224,"pages":226,"issue":228},{"VOID":225},"70",{"VOID":227},"1161-1166",{"VOID":229},"8",13,{"total":230,"publishYear":24,"statisticByYear":232},{"2020":156,"2022":156},"1992-08-01",1992,[],false,{"id":238,"createTime":239,"updateTime":239,"relativeEntities":240,"slug":241,"properties":242,"entityType":148,"verifyStatus":23,"verifyTime":256,"verifyNote":149,"syncStatus":23,"languages":257,"translateLanguages":24,"viewCount":25,"primaryUrl":258,"fullTextUrl":24,"authors":259,"publicationType":196,"publisherRelationship":291,"citationCount":323,"citationInfo":324,"publishDate":327,"publishYear":328,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":329,"isForceReanalyzing":236},"13f84eef-4160-4500-9a62-7c9f6d384f17","2024-08-30T23:17:03.763+00:00",[],"Effects-of-some-naturally-occurring-prostanoids-and-some-cyclooxygenase-inhibitors-on-the-contractility-of-the-human-lower-uterine-segment-in-vitro",{"mag":243,"keywords":245,"openalex":246,"abstract":248,"title":250,"pm":252,"doi":254},{"VOID":244},"1972457815",{},{"VOID":247},"W1972457815",{"EN":249},"\u003Cjats:p> The contractility of strips of human lower segment myometrium obtained from elective cesarean section performed at term of pregnancy was studied in vitro. The effects of indomethacin and tiaprofen upon spontaneous contractile activity were examined. Concentration–effect curves for PGD\u003Cjats:sub>2\u003C\u002Fjats:sub>, PGE\u003Cjats:sub>2\u003C\u002Fjats:sub>, PGF\u003Cjats:sub>2α\u003C\u002Fjats:sub>, 6-keto-PGE\u003Cjats:sub>1\u003C\u002Fjats:sub>, and 6-keto-PGF\u003Cjats:sub>1α\u003C\u002Fjats:sub>, were constructed in the presence of indomethacin. Neither indomethacin nor tiaprofen in concentrations up to 100 μmol\u002FL had any effect upon spontaneous activity. Contractions were induced by the prostanoids with the following mean EC\u003Cjats:sub>50\u003C\u002Fjats:sub> values: PGE\u003Cjats:sub>2\u003C\u002Fjats:sub>, 13 nM; PGF\u003Cjats:sub>2α\u003C\u002Fjats:sub>, 250 nM; PGD\u003Cjats:sub>2\u003C\u002Fjats:sub>, 790 nM; both 6-keto-PGF\u003Cjats:sub>1α\u003C\u002Fjats:sub> and 6-keto-PGE\u003Cjats:sub>1\u003C\u002Fjats:sub> were without effect in concentrations up to 30 μmol\u002FL. In some tissues PGE\u003Cjats:sub>2\u003C\u002Fjats:sub> inhibited spontaneous activity with a mean IC\u003Cjats:sub>50\u003C\u002Fjats:sub> of 100 nM. No other prostanoid tested caused inhibition under any circumstance. The marked potency differences between the natural prostanoids is an important parameter to consider when assessing their relative contributions to the process of parturition and the design of new therapeutic agents for the management of preterm labour.Key words: prostaglandins, indomethacin, myometrium, human, uterine contraction. \u003C\u002Fjats:p>",{"EN":251},"Effects of some naturally occurring prostanoids and some cyclooxygenase inhibitors on the contractility of the human lower uterine segment in vitro",{"VOID":253},"7834575",{"VOID":255},"10.1139\u002Fy94-123","2024-08-30T23:17:03.762+00:00",[151],"http:\u002F\u002Fwww.nrcresearchpress.com\u002Fdoi\u002F10.1139\u002Fy94-123",[260,269],{"id":261,"sortIndex":156,"researcher":24,"roles":262,"affiliations":263,"properties":264},"49b3f0a3-1a38-4bc8-8bdc-155c97a048a6",[],[],{"openalex":265,"title":267},{"VOID":266},"A5028575065",{"EN":268},"R.Y. Dyal",{"id":270,"sortIndex":25,"researcher":24,"roles":271,"affiliations":272,"properties":284},"292c34de-fa56-4700-b640-eddc3cb24d63",[],[273],{"id":274,"sortIndex":25,"affiliation":275,"properties":24},"c4cef027-f543-4ac0-877a-d2ba7cd96f53",{"id":276,"createTime":277,"updateTime":278,"relativeEntities":279,"slug":280,"properties":281,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"410b3b20-deb9-4718-a668-4a56357266ce","2024-04-18T11:51:30.297+00:00","2024-08-30T23:17:03.772+00:00",[],"Department-of-Obstetrics-and-Gynecology-McMaster-University-Hamilton-ON-Canada",{"title":282},{"EN":283},"Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada",{"openalex":285,"orcid":287,"title":289},{"VOID":286},"A5014858512",{"VOID":288},"https:\u002F\u002Forcid.org\u002F0000-0003-0381-9719",{"EN":290},"Denis Crankshaw",{"url":24,"publisher":292,"properties":317},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":293,"slug":10,"properties":294,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":300,"manageAffiliations":301,"indexDatabases":302,"url":124,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":295,"issn":296,"introduce":297,"eissn":298,"title":299},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[303,310],{"id":105,"indexDatabase":304,"url":120,"indexYears":24,"academicFieldIds":309,"indexDatabaseRanking":24},{"id":107,"createTime":108,"updateTime":109,"relativeEntities":305,"label":306,"description":307,"key":116,"publicationTags":308,"standard":24},[],{"EN":112,"VI":112},{"VI":114,"EN":115},[118,119],[122,123],{"id":83,"indexDatabase":311,"url":96,"indexYears":97,"academicFieldIds":316,"indexDatabaseRanking":103},{"id":85,"createTime":86,"updateTime":87,"relativeEntities":312,"label":313,"description":314,"key":93,"publicationTags":315,"standard":24},[],{"EN":90,"VI":90},{"EN":90,"VI":92},[95],[99,100,101,102],{"volume":318,"pages":320,"issue":322},{"VOID":319},"72",{"VOID":321},"870-874",{"VOID":229},51,{"total":323,"publishYear":24,"statisticByYear":325},{"2013":188,"2014":326,"2015":156,"2016":156,"2017":156,"2018":156,"2019":156,"2020":156,"2021":156,"2022":188,"2023":156,"2024":156},4,"1994-08-01",1994,[],{"id":331,"createTime":332,"updateTime":332,"relativeEntities":333,"slug":334,"properties":335,"entityType":148,"verifyStatus":349,"verifyTime":332,"verifyNote":350,"syncStatus":23,"languages":351,"translateLanguages":24,"viewCount":25,"primaryUrl":352,"fullTextUrl":24,"authors":353,"publicationType":196,"publisherRelationship":546,"citationCount":579,"citationInfo":580,"publishDate":582,"publishYear":583,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":584,"isForceReanalyzing":236},"ef3ce320-a209-42ca-af51-436b01ff53cd","2024-09-24T22:51:30.644+00:00",[],"Endothelin-1-induces-neutrophil-recruitment-in-adaptive-inflammation-via-TNF%CE%B1-and-CXCL1-CXCR2-in-mice",{"mag":336,"keywords":338,"openalex":339,"abstract":341,"title":343,"pm":345,"doi":347},{"VOID":337},"2098430012",{},{"VOID":340},"W2098430012",{"EN":342},"\u003Cjats:p>Endothelin mediates neutrophil recruitment during innate inflammation. Herein we address whether endothelin-1 (ET-1) is involved in neutrophil recruitment in adaptive inflammation in mice, and its mechanisms. Pharmacological treatments were used to determine the role of endothelin in neutrophil recruitment to the peritoneal cavity of mice challenged with antigen (ovalbumin) or ET-1. Levels of ET-1, tumour necrosis factor α (TNFα), and CXC chemokine ligand 1 (CXCL1) were determined by enzyme-linked immunosorbent assay. Neutrophil migration and flow cytometry analyses were performed 4 h after the intraperitoneal stimulus. ET-1 induced dose-dependent neutrophil recruitment to the peritoneal cavity. Treatment with the non-selective ET\u003Cjats:sub>A\u003C\u002Fjats:sub>\u002FET\u003Cjats:sub>B\u003C\u002Fjats:sub>receptor antagonist bosentan, and selective ET\u003Cjats:sub>A\u003C\u002Fjats:sub>or ET\u003Cjats:sub>B\u003C\u002Fjats:sub>receptor antagonists BQ-123 or BQ-788, respectively, inhibited ET-1- and ovalbumin-induced neutrophil migration to the peritoneal cavity. In agreement with the above, the antigen challenge significantly increased levels of ET-1 in peritoneal exudates. The ET-1- and ovalbumin-induced neutrophil recruitment were reduced in TNFR1 deficient mice, and by treatments targeting CXCL1 or CXC chemokine receptor 2 (CXCR2); further, treatment with bosentan, BQ-123, or BQ-788 inhibited ET-1- and antigen-induced production of TNFα and CXCL1. Furthermore, ET-1 and ovalbumin challenge induced an increase in the number of cells expressing the Gr1\u003Cjats:sup>+\u003C\u002Fjats:sup>markers in the granulocyte gate, CD11c\u003Cjats:sup>+\u003C\u002Fjats:sup>markers in the monocyte gate, and CD4\u003Cjats:sup>+\u003C\u002Fjats:sup>and CD45\u003Cjats:sup>+\u003C\u002Fjats:sup>(B220) markers in the lymphocyte gate in an ET\u003Cjats:sub>A\u003C\u002Fjats:sub>- and ET\u003Cjats:sub>B\u003C\u002Fjats:sub>-dependent manner, as determined by flow cytometry analysis, suggesting that ET-1 might be involved in the recruitment of neutrophils and other cells in adaptive inflammation. Therefore, the present study demonstrates that ET-1 is an important mediator for neutrophil recruitment in adaptive inflammation via TNFα and CXCL1\u002FCXCR2-dependent mechanism.\u003C\u002Fjats:p>",{"EN":344},"Endothelin-1 induces neutrophil recruitment in adaptive inflammation via TNFα and CXCL1\u002FCXCR2 in mice",{"VOID":346},"22320712",{"VOID":348},"10.1139\u002Fy11-116","VERIFIED","Auto Verify",[151],"http:\u002F\u002Fwww.nrcresearchpress.com\u002Fdoi\u002F10.1139\u002Fy11-116",[354,376,393,410,428,450,477,494,512,530],{"id":355,"sortIndex":356,"researcher":24,"roles":357,"affiliations":358,"properties":369},"9fe2e706-cabc-4744-8ad2-6f6b1a20ff98",8,[],[359],{"id":360,"sortIndex":25,"affiliation":361,"properties":24},"104299f2-073c-4087-a51a-34c03e18734b",{"id":362,"createTime":363,"updateTime":363,"relativeEntities":364,"slug":365,"properties":366,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"838769c9-2654-4145-b024-56a2f3fb9664","2024-09-24T22:51:30.675+00:00",[],"Department-of-Pharmacology-School-of-Medicine-of-Ribeirao-Preto-University-of-Sao-Paulo-Avenida-Bandeirantes-3900-14050-990-Ribeirao-Preto-Sao-Paulo-Brazil-",{"title":367},{"EN":368},"Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes, 3900, 14050-990, Ribeirao Preto, Sao Paulo, Brazil.",{"openalex":370,"orcid":372,"title":374},{"VOID":371},"A5050684767",{"VOID":373},"https:\u002F\u002Forcid.org\u002F0000-0003-4755-1670",{"EN":375},"Fernando Q. 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Atherosclerosis is an inflammatory disease and as such, immune-mediated cell killing plays an important role. Recent studies have suggested that Granzyme B and perforin play an important role in atherogenesis. 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Immunol., 169, 6850, 10.4049\u002Fjimmunol.169.12.6850",{"doi":1074},"10.4049\u002Fjimmunol.169.12.6850",{"id":1076,"createTime":1077,"updateTime":1077,"relativeEntities":1078,"slug":1079,"properties":1080,"entityType":148,"verifyStatus":23,"verifyTime":1077,"verifyNote":149,"syncStatus":23,"languages":1094,"translateLanguages":24,"viewCount":25,"primaryUrl":1095,"fullTextUrl":24,"authors":1096,"publicationType":196,"publisherRelationship":1143,"citationCount":356,"citationInfo":1176,"publishDate":1178,"publishYear":1179,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1180,"isForceReanalyzing":236},"68a240fa-4ab4-4774-b6b4-b0f3a1e40dcc","2024-11-27T22:29:09.019+00:00",[],"Characterization-of-Ca-sup-2-sup-release-from-heterogeneous-Ca-sup-2-sup-stores-in-sarcoplasmic-reticulum-isolated-from-arterial-and-gastric-smooth-muscle",{"mag":1081,"keywords":1083,"openalex":1084,"abstract":1086,"title":1088,"pm":1090,"doi":1092},{"VOID":1082},"2059391905",{},{"VOID":1085},"W2059391905",{"EN":1087},"\u003Cjats:p>Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup>transport was investigated in vesicles of sarcoplasmic reticulum subfractionated from bovine main pulmonary artery and porcine gastric antrum using digitonin binding and zonal density gradient centrifugation. Gradient fractions recovered at 15–33% sucrose were studied as the sarcoplasmic reticulum component using Fluo-3 fluorescence or\u003Cjats:sup>45\u003C\u002Fjats:sup>Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup>Millipore filtration. Thapsigargin blocked active Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup>uptake and induced a slow Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup>release from actively loaded vesicles. Unidirectional\u003Cjats:sup>45\u003C\u002Fjats:sup>Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup>efflux from passively loaded vesicles showed multicompartmental kinetics. The time course of an initial fast component could not be quantitatively measured with the sampling method. The slow release had a half-time of several minutes. Both components were inhibited by 20 μM ruthenium red and 10 mM Mg\u003Cjats:sup>2+\u003C\u002Fjats:sup>. Caffeine, inositol 1,4,5-trisphosphate, ATP, and diltiazem accelerated the slow component. A Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup>release component activated by ryanodine or cyclic adenosine diphosphate ribose was resolved with Fluo-3. Comparison of tissue responses showed that the fast Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup>release was significantly smaller and more sensitive to inhibition by Mg\u003Cjats:sup>2+\u003C\u002Fjats:sup>and ruthenium red in arterial vesicles. They released more Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup>in response to inositol 1,4,5-trisphosphate and were more sensitive to activation by cyclic adenosine diphosphate ribose. Ryanodine and caffeine, in contrast, were more effective in gastric antrum. In each tissue, the fraction of the Ca\u003Cjats:sup>+2\u003C\u002Fjats:sup>store released by sequential application of caffeine and inositol 1,4,5-trisphosphate depended on the order applied and was additive. The results indicate that sarcoplasmic reticulum purified from arterial and gastric smooth muscle represents vesicle subpopulations that retain functional Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup>channels that reflect tissue-specific pharmacological modulation. The relationship of these differences to physiological responses has not been determined.Key words: calcium channels, smooth muscle, sarcoplasmic reticulum.\u003C\u002Fjats:p>",{"EN":1089},"Characterization of Ca\u003Csup>2+\u003C\u002Fsup>release from heterogeneous Ca\u003Csup>2+\u003C\u002Fsup>stores in sarcoplasmic reticulum isolated from arterial and gastric smooth muscle",{"VOID":1091},"12117308",{"VOID":1093},"10.1139\u002Fy02-083",[151],"http:\u002F\u002Fwww.nrcresearchpress.com\u002Fdoi\u002F10.1139\u002Fy02-083",[1097,1106,1125,1134],{"id":1098,"sortIndex":412,"researcher":24,"roles":1099,"affiliations":1100,"properties":1101},"177d9d5b-e562-45c5-8cd5-eb7a7303fce8",[],[],{"openalex":1102,"title":1104},{"VOID":1103},"A5036229099",{"EN":1105},"R. 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J., 290, 259, 10.1042\u002Fbj2900259",{"doi":1461},"10.1042\u002Fbj2900259",{"id":1463,"createTime":1464,"updateTime":1464,"relativeEntities":1465,"slug":1466,"properties":1467,"entityType":148,"verifyStatus":349,"verifyTime":1464,"verifyNote":350,"syncStatus":23,"languages":1483,"translateLanguages":24,"viewCount":25,"primaryUrl":1484,"fullTextUrl":24,"authors":1485,"publicationType":196,"publisherRelationship":1638,"citationCount":1671,"citationInfo":1672,"publishDate":1674,"publishYear":1675,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1676,"isForceReanalyzing":236},"277402c2-e546-4203-b6b5-90814a77b9bb","2024-10-09T22:06:38.969+00:00",[],"Involvement-of-UTP-in-protection-of-cardiomyocytes-from-hypoxic-stressThis-article-is-one-of-a-selection-of-papers-from-the-NATO-Advanced-Research-Workshop-on-Translational-Knowledge-for-Heart-Health-published-in-part-2-of-a-2-part-Special-Issue-",{"mag":1468,"keywords":1470,"pmc":1471,"openalex":1473,"abstract":1475,"title":1477,"pm":1479,"doi":1481},{"VOID":1469},"1598038078",{},{"VOID":1472},"3415250",{"VOID":1474},"W1598038078",{"EN":1476},"\u003Cjats:p> Massive amounts of nucleotides are released during ischemia in the cardiovascular system. Although the effect of the purine nucleotide ATP has been intensively studied in myocardial infarction, the cardioprotective role of the pyrimidine nucleotide UTP is still unclear, especially in the cardiovascular system. The purpose of our study was to elucidate the protective effects of UTP receptor activation and describe the downstream cascade for the cardioprotective effect. Cultured cardiomyocytes and left anterior descending (LAD)-ligated rat hearts were pretreated with UTP and exposed to hypoxia–ischemia. In vitro experiments revealed that UTP reduced cardiomyocyte death induced by hypoxia, an effect that was diminished by suramin. UTP caused several effects that could trigger a cardioprotective response: a transient increase of [Ca\u003Cjats:sup>2+\u003C\u002Fjats:sup>]\u003Cjats:sub>i\u003C\u002Fjats:sub>, an effect that was abolished by PPADS or RB2; phosphorylation of the kinases ERK and Akt, which was abolished by U0126 and LY294002, respectively; and reduced mitochondrial calcium elevation after hypoxia. In vivo experiments revealed that UTP maintained ATP levels, improved mitochondrial activity, and reduced infarct size. In conclusion, UTP administrated before ischemia reduced infarct size and improved myocardial function. Reduction of mitochondrial calcium overload can partially explain the protective effect of UTP after hypoxic–ischemic injury. \u003C\u002Fjats:p>",{"EN":1478},"Involvement of UTP in protection of cardiomyocytes from hypoxic stressThis article is one of a selection of papers from the NATO Advanced Research Workshop on Translational Knowledge for Heart Health (published in part 2 of a 2-part Special Issue).",{"VOID":1480},"19370082",{"VOID":1482},"10.1139\u002Fy09-010",[151],"http:\u002F\u002Fwww.nrcresearchpress.com\u002Fdoi\u002F10.1139\u002FY09-010",[1486,1528,1555,1584,1611],{"id":1487,"sortIndex":412,"researcher":24,"roles":1488,"affiliations":1489,"properties":1521},"ddf8e2de-cd14-4739-abaa-b714deee8c2d",[],[1490,1500,1511],{"id":1491,"sortIndex":188,"affiliation":1492,"properties":24},"7c14d56a-d135-4e4b-bcd1-70c8daf3a19a",{"id":1493,"createTime":1494,"updateTime":1494,"relativeEntities":1495,"slug":1496,"properties":1497,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"49cc9312-83b4-4538-a5aa-f934d7c6b9a7","2024-10-09T22:06:38.990+00:00",[],"Laboratory-of-Bioorganic-Chemistry-NIDDK-NIH-Bethesda-Maryland-USA-",{"title":1498},{"EN":1499},"Laboratory of Bioorganic Chemistry, NIDDK, NIH, Bethesda, Maryland, USA.",{"id":1501,"sortIndex":156,"affiliation":1502,"properties":24},"3f649438-640e-4a1f-bf27-630f61fb9ca1",{"id":1503,"createTime":1504,"updateTime":1505,"relativeEntities":1506,"slug":1507,"properties":1508,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"408c11d1-f7fe-44b4-9db5-032ccb648702","2023-12-11T05:07:02.812+00:00","2024-10-09T22:06:38.988+00:00",[],"Faculty-of-Life-Sciences-Bar-Ilan-University-Ramat-Gan-52900-Israel",{"title":1509},{"VI":1510},"Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel",{"id":1512,"sortIndex":25,"affiliation":1513,"properties":24},"a880a58e-4cbb-49cb-93d1-469c0bac8772",{"id":1514,"createTime":1515,"updateTime":1515,"relativeEntities":1516,"slug":1517,"properties":1518,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"7eb3b28a-3da1-4af3-9bec-ec88d8eb60c3","2024-10-09T22:06:38.984+00:00",[],"FMRC-Rabin-Medical-Center-Tel-Aviv-University-Tel-Aviv-Israel-",{"title":1519},{"EN":1520},"FMRC, Rabin Medical Center, Tel Aviv University, Tel Aviv, Israel.",{"openalex":1522,"orcid":1524,"title":1526},{"VOID":1523},"A5091587615",{"VOID":1525},"https:\u002F\u002Forcid.org\u002F0000-0001-8104-1493",{"EN":1527},"Kenneth A. 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These concentrations of PRL had no effect on the mRNA expression of osteocalcin and osteopontin, nor on mineralization. High pathologic concentrations of PRL (1000 ng\u002FmL) may downregulate expression of genes that are essential for osteoblast differentiation and functions. 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The slow waves, originating at the submuscular surface where a network of interstitial cells of Cajal (ICCs) is found, possess a pacemaker component. Activation of the pacemaker component is insensitive to voltage changes and L-type calcium channel blockers, and is postulated to involve a metabolic clock sensitive to cyclic AMP. SLAPs are more prominent in the longitudinal muscle. To understand the contribution circular muscle cells make to the generation of these action potentials, a circular muscle preparation (devoid of the submuscular ICC – smooth muscle network, longitudinal muscle, and myenteric plexus) was developed. Circular muscle preparations were spontaneously quiescent, with a resting membrane potential of −62.9 ± 0.6 mV. Ba\u003Cjats:sup>2+\u003C\u002Fjats:sup> (0.5 mM) depolarized the cells to −51.8 ± 0.6 mV and induced electrical oscillations with a frequency, duration, amplitude, and rate of rise equal to 6.6 ± 0.4 cpm, 2.2 ± 0.2 s, 19.4 ± 0.9 mV, and 21.8 ± 1.7 mV\u002Fs, respectively. In most cases, Ba\u003Cjats:sup>2+\u003C\u002Fjats:sup>-induced oscillations were preceded by a prepotential of 4.4 ± 0.3 mV, with a rate of rise of 1.1 ± 0.1 mV\u002Fs. Ba\u003Cjats:sup>2+\u003C\u002Fjats:sup>-induced oscillations were abolished by 1 μM D600 as well as by repolarization of 6–12 mV. Addition of 0.1 μM Bay K8644 in the presence of Ba\u003Cjats:sup>2+\u003C\u002Fjats:sup> further depolarized circular muscle cells to −42.4 ± 0.8 mV and increased the oscillation frequency to 16.8 ± 1.8 cpm. The electrical oscillations induced in circular muscle preparations by Ba\u003Cjats:sup>2+\u003C\u002Fjats:sup> and Bay K8644 were similar to the SLAPs exhibited by the isolated longitudinal muscle layer, indicating that generation of SLAPs is an intrinsic property of smooth muscle cells. Forskolin (1 μM), previously shown to dramatically decrease the frequency but not the amplitude of slow waves in preparations including the submuscular ICC network, decreased the amplitude of the Ba\u003Cjats:sup>2+\u003C\u002Fjats:sup>-induced oscillations in circular muscle preparations without changing the frequency. These results provide strong evidence for the hypothesis that the submuscular ICC – smooth muscle network is essential for the initiation of the pacemaker component of the colonic slow waves. The mechanism for regulating the frequency of slow waves is different from that responsible for the Ba\u003Cjats:sup>2+\u003C\u002Fjats:sup>-induced oscillations in circular muscle preparations. Circular muscle cells are shown to be excitable and capable of generating oscillatory activity dominated by L-type calcium channel activity, which is regulated by K\u003Cjats:sup>+\u003C\u002Fjats:sup> conductance.Key words: interstitial cells of Cajal, smooth muscle, dog colon, barium chloride, potassium conductance, Bay K8644, pacemaking activity. \u003C\u002Fjats:p>",{"EN":2238},"Canine colonic circular muscle generates action potentials without the pacemaker component",{"VOID":2240},"7516818",{"VOID":2242},"10.1139\u002Fy94-012",[151],"http:\u002F\u002Fwww.nrcresearchpress.com\u002Fdoi\u002F10.1139\u002Fy94-012",[2246,2267],{"id":2247,"sortIndex":25,"researcher":24,"roles":2248,"affiliations":2249,"properties":2260},"c81f9db4-21a3-4329-b803-e139d176ba2f",[],[2250],{"id":2251,"sortIndex":25,"affiliation":2252,"properties":24},"2a9d46bf-bd2c-4461-b99c-8110f1d64bb2",{"id":2253,"createTime":2254,"updateTime":2254,"relativeEntities":2255,"slug":2256,"properties":2257,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"b9567490-6f44-4048-b3a2-25249560e5ef","2024-09-12T21:07:12.711+00:00",[],"Department-of-Biomedical-Science-McMaster-University-Hamilton-ON-Canada-",{"title":2258},{"EN":2259},"Department of Biomedical Science, McMaster University, Hamilton, ON, Canada.",{"openalex":2261,"orcid":2263,"title":2265},{"VOID":2262},"A5014211861",{"VOID":2264},"https:\u002F\u002Forcid.org\u002F0009-0007-9709-833X",{"EN":2266},"L W Liu",{"id":2268,"sortIndex":156,"researcher":24,"roles":2269,"affiliations":2270,"properties":2271},"7ed96d3d-0644-4163-85b6-128bf4eabdeb",[],[],{"openalex":2272,"orcid":2274,"title":2276},{"VOID":2273},"A5078446730",{"VOID":2275},"https:\u002F\u002Forcid.org\u002F0000-0001-8016-1055",{"EN":2277},"Jan D. Huizinga",{"url":24,"publisher":2279,"properties":2304},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2280,"slug":10,"properties":2281,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":2287,"manageAffiliations":2288,"indexDatabases":2289,"url":124,"thumbnailPath":24,"statistic":24,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":2282,"issn":2283,"introduce":2284,"eissn":2285,"title":2286},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[2290,2297],{"id":105,"indexDatabase":2291,"url":120,"indexYears":24,"academicFieldIds":2296,"indexDatabaseRanking":24},{"id":107,"createTime":108,"updateTime":109,"relativeEntities":2292,"label":2293,"description":2294,"key":116,"publicationTags":2295,"standard":24},[],{"EN":112,"VI":112},{"VI":114,"EN":115},[118,119],[122,123],{"id":83,"indexDatabase":2298,"url":96,"indexYears":97,"academicFieldIds":2303,"indexDatabaseRanking":103},{"id":85,"createTime":86,"updateTime":87,"relativeEntities":2299,"label":2300,"description":2301,"key":93,"publicationTags":2302,"standard":24},[],{"EN":90,"VI":90},{"EN":90,"VI":92},[95],[99,100,101,102],{"volume":2305,"pages":2306,"issue":2308},{"VOID":319},{"VOID":2307},"70-81",{"VOID":853},24,{"total":2309,"publishYear":24,"statisticByYear":2311},{"2012":156,"2015":156,"2017":156,"2018":188},"1994-01-01",[],{"id":2315,"createTime":2316,"updateTime":2316,"relativeEntities":2317,"slug":2318,"properties":2319,"entityType":148,"verifyStatus":23,"verifyTime":2316,"verifyNote":149,"syncStatus":23,"languages":2333,"translateLanguages":24,"viewCount":25,"primaryUrl":2334,"fullTextUrl":24,"authors":2335,"publicationType":196,"publisherRelationship":2372,"citationCount":2403,"citationInfo":2404,"publishDate":2406,"publishYear":234,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":2407,"isForceReanalyzing":236},"8c9aa20c-71fc-4ae4-9343-46d489ba89e0","2024-09-12T21:06:59.829+00:00",[],"Excitability-of-canine-colon-circular-muscle-disconnected-from-the-network-of-interstitial-cells-of-Cajal",{"mag":2320,"keywords":2322,"openalex":2323,"abstract":2325,"title":2327,"pm":2329,"doi":2331},{"VOID":2321},"2110799107",{},{"VOID":2324},"W2110799107",{"EN":2326},"\u003Cjats:p> The 6 cpm omnipresent slow waves recorded in the circular muscle (CM) layer of canine colon are generated at the submucosal surface of the CM layer. After removal of the submucosal network of interstitial cells of Cajal (ICC), 66% of the CM preparations (25 of 38) were quiescent in Krebs solution. In the presence of carbachol, seven of nine of these spontaneously quiescent CM preparations demonstrated slow wave-like activity with mean frequency, duration and amplitude of 5.9 ± 0.4 cpm, 2.8 ± 0.5 s, and 0.8 ± 0.2 mV, respectively. Similar slow wave-like activities were induced by TEA (seven out of eight quiescent CM preparations) with frequency, duration and amplitude of 6.1 ± 0.2 cpm, 2.7 ± 0.5 s, and 1.0 ± 0.2 mV, respectively, and by BaCl\u003Cjats:sub>2\u003C\u002Fjats:sub> (eight of eight quiescent CM preparations) with frequency, duration, and amplitude of 6.3 ± 0.3 cpm, 1.8 ± 0.2 s, and 0.5 ± 0.1 mV, respectively. All the induced activities were abolished in the presence of 1 μM D600. CM preparations with the submucosal ICC network intact (ICC–CM) showed slow wave activity in Krebs solution at a frequency of 6.2 ± 0.2 cpm, a duration of 3.6 ± 0.2 s, and an amplitude of 1.0 ± 0.1 mV (n = 22). When ICC–CM preparations were stimulated by BaCl\u003Cjats:sub>2\u003C\u002Fjats:sub>, carbachol, or TEA, the slow wave frequency did not change significantly, but the duration increased as well as the amplitude. In the presence of D600, the upstroke of slow waves remained and the frequency was not affected. The ability to generate slow wave-like activity after potassium conductance blockade in spontaneously quiescent CM disconnected from the ICC network suggested that circular muscle cells have ionic mechanisms for intrinsic oscillatory activity and are capable of actively participating in the conduction and generation of slow waves.Key words: colon, smooth muscle, interstitial cells of Cajal, canine, slow waves, excitability. \u003C\u002Fjats:p>",{"EN":2328},"Excitability of canine colon circular muscle disconnected from the network of interstitial cells of Cajal",{"VOID":2330},"1521181",{"VOID":2332},"10.1139\u002Fy92-036",[151],"http:\u002F\u002Fwww.nrcresearchpress.com\u002Fdoi\u002F10.1139\u002Fy92-036",[2336,2345,2353],{"id":2337,"sortIndex":156,"researcher":24,"roles":2338,"affiliations":2339,"properties":2340},"e6f7732b-80fa-48b9-b8df-f41957c726ce",[],[],{"openalex":2341,"title":2343},{"VOID":2342},"A5047151696",{"EN":2344},"E. E. Daniel",{"id":2346,"sortIndex":188,"researcher":24,"roles":2347,"affiliations":2348,"properties":2349},"74f634bd-b739-4e49-a2ce-4d6d70016fa9",[],[],{"openalex":2350,"orcid":2351,"title":2352},{"VOID":2273},{"VOID":2275},{"EN":2277},{"id":2354,"sortIndex":25,"researcher":24,"roles":2355,"affiliations":2356,"properties":2368},"97b31593-2cba-467a-a157-d74b33b13a17",[],[2357],{"id":2358,"sortIndex":25,"affiliation":2359,"properties":24},"8687cfc0-8ae6-4d6a-9aa9-c43652cb6b8f",{"id":2360,"createTime":2361,"updateTime":2362,"relativeEntities":2363,"slug":2364,"properties":2365,"entityType":69,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"a51eb6a4-dbd1-44d6-af6e-89328c51f971","2024-01-12T07:12:47.532+00:00","2024-09-12T21:06:59.856+00:00",[],"Department-of-Biomedical-Sciences-McMaster-University-Hamilton-Ont-Canada",{"title":2366},{"VI":2367},"Department of Biomedical Sciences, McMaster University, Hamilton, Ont. 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