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Tổng cộng có 112 nghiên cứu đã được sử dụng để phát triển mô hình và 57 nghiên cứu dùng để dự đoán DDI. 93% tỷ lệ diện tích dưới đường cong của nồng độ huyết tương theo thời gian (AUC) dự đoán và 94% tỷ lệ nồng độ đỉnh huyết tương (Cmax) nằm trong hai lần giá trị quan sát được. Nghiên cứu này đặt nền tảng cho việc đánh giá nền tảng OSP về các dự đoán PBPK đáng tin cậy đối với DDI do enzym và vận chuyển dang môi trong quá trình phát triển thuốc được thông tin bằng mô hình. 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Sodium‐glucose cotransporter 2 inhibitors (\u003Cjats:styled-content style=\"fixed-case\">SGLT\u003C\u002Fjats:styled-content>2i) have been shown to be able to reverse hyperfiltration in some patients. We developed a mechanistic computational model of the kidney that explains the interplay of hyperglycemia and hyperfiltration and integrates the pharmacokinetics\u002Fpharmacodynamics (\u003Cjats:styled-content style=\"fixed-case\">PK\u003C\u002Fjats:styled-content>\u002F\u003Cjats:styled-content style=\"fixed-case\">PD\u003C\u002Fjats:styled-content>) of the \u003Cjats:styled-content style=\"fixed-case\">SGLT\u003C\u002Fjats:styled-content>2i dapagliflozin. Based on simulation results, we propose kidney growth as the necessary process for hyperfiltration progression. 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