[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_4197c6f3-b8e2-4073-8116-513df4da7c79":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:4197c6f3-b8e2-4073-8116-513df4da7c79,\"}":232},{"code":4,"data":5,"meta":22},"SUCCESS",{"id":6,"createTime":7,"updateTime":8,"relativeEntities":9,"slug":10,"properties":11,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":24,"manageAffiliations":57,"indexDatabases":82,"url":22,"thumbnailPath":22,"statistic":125,"gsStatistic":22,"type":231,"analyzePriority":22},"4197c6f3-b8e2-4073-8116-513df4da7c79","2024-04-08T09:10:15.333+00:00","2025-11-21T09:59:01.361+00:00",[],"Breast-Cancer",{"issn":12,"eissn":14,"title":16,"url":18},{"VOID":13},"18804233",{"VOID":15},"13406868",{"EN":17},"Breast Cancer",{"VOID":19},"https:\u002F\u002Flink.springer.com\u002Fjournal\u002F12282","PUBLISHER","PENDING",null,0,[25,33,41,49],{"id":26,"createTime":27,"updateTime":28,"relativeEntities":29,"label":30,"description":32,"parentId":22,"standard":22,"scholarHubFieldId":22},"0254e3e5-c28d-4a33-83da-81bc94d29ffd","2023-05-29T10:24:00.931+00:00","2023-11-21T07:56:41.438+00:00",[],{"EN":31},"Medicine (miscellaneous)",{},{"id":34,"createTime":35,"updateTime":36,"relativeEntities":37,"label":38,"description":40,"parentId":22,"standard":22,"scholarHubFieldId":22},"d9687dc3-fd83-46ff-aef4-1925044c24eb","2023-05-29T10:24:05.052+00:00","2023-11-21T05:08:37.643+00:00",[],{"EN":39},"Oncology",{},{"id":42,"createTime":43,"updateTime":44,"relativeEntities":45,"label":46,"description":48,"parentId":22,"standard":22,"scholarHubFieldId":22},"8d3ee16d-8f93-4e34-b94e-cd3a00dde338","2023-05-29T10:24:36.755+00:00","2023-11-21T05:10:53.773+00:00",[],{"EN":47},"Pharmacology (medical)",{},{"id":50,"createTime":51,"updateTime":52,"relativeEntities":53,"label":54,"description":56,"parentId":22,"standard":22,"scholarHubFieldId":22},"e8fbc4e0-9522-4354-a98f-7f288efdcb2a","2023-05-29T10:24:07.493+00:00","2023-11-21T08:07:05.805+00:00",[],{"EN":55},"Radiology, Nuclear Medicine and Imaging",{},[58,71],{"id":59,"createTime":60,"updateTime":61,"relativeEntities":62,"slug":63,"properties":64,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":68,"url":22,"parentIds":69,"statistic":22},"097ed5ab-2745-4d28-a6f8-9cef8109dee5","2023-05-29T10:24:42.580+00:00","2025-06-11T22:26:19.069+00:00",[],"Springer-Japan",{"title":65},{"EN":66},"Springer Japan","AFFILIATION",6,[70],"9a7c7208-b28a-42c2-a634-5a7f90eee3ab",{"id":72,"createTime":73,"updateTime":74,"relativeEntities":75,"slug":76,"properties":77,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":80,"url":22,"parentIds":81,"statistic":22},"703e6040-17b1-4447-a4fc-241fbd0f3879","2023-05-29T12:10:46.581+00:00","2023-12-20T07:50:15.296+00:00",[],"SPRINGER-JAPAN-KK",{"title":78},{"EN":79},"SPRINGER JAPAN KK",7,[70],[83,105],{"id":84,"indexDatabase":85,"url":97,"indexYears":98,"academicFieldIds":99,"indexDatabaseRanking":104},"d3d48b6e-c7ab-4476-b9f1-ba517389a5ec",{"id":86,"createTime":87,"updateTime":88,"relativeEntities":89,"label":90,"description":92,"key":94,"publicationTags":95,"standard":22},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9","2023-05-22T09:57:18.509+00:00","2025-11-21T10:07:52.274+00:00",[],{"EN":91,"VI":91},"Scopus - Elsevier",{"EN":91,"VI":93},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[96],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F83418","1994-2025",[100,101,102,103],"46eddd1f-e049-4237-8609-9d60083086ad","e89cebf4-fecf-4b74-8ab4-88fca891e4c2","462e3fe4-4fc0-4c02-80d6-8d2af4fc74ea","a2541f09-5a54-41e7-820b-effbd7bac237","SCOPUS__Q1",{"id":106,"indexDatabase":107,"url":121,"indexYears":22,"academicFieldIds":122,"indexDatabaseRanking":22},"6ec0f3f6-11ad-483f-999d-a28689e25965",{"id":108,"createTime":109,"updateTime":110,"relativeEntities":111,"label":112,"description":114,"key":117,"publicationTags":118,"standard":22},"a4921856-b128-4d9f-8f1f-e80813d3bbd4","2023-05-22T09:59:31.026+00:00","2025-11-21T10:07:52.153+00:00",[],{"EN":113,"VI":113},"ISI\u002FSCIE - Science Citation Index Expanded",{"VI":115,"EN":116},"Cơ sở dữ liệu SCIE","SCIE database","scie",[119,120],"SCIE","ISI","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=1340-6868",[123,124],"248e54de-c562-4c06-8a10-d7f8a37c06fe","373912bc-55c0-410a-8280-da8a470d15e2",{"impactFactor":23,"impactFactorByYear":126,"i10Index":140,"i10IndexLast5Year":141,"totalPublication":142,"totalPublicationByYear":143,"totalCitation":171,"totalCitationByYear":172,"totalCitationPerPublication":201,"totalCitationPerPublicationByYear":202,"hindexLast5Year":230,"hindex":230},{"2008":127,"2009":128,"2012":129,"2013":130,"2014":131,"2015":132,"2016":131,"2017":133,"2018":134,"2019":135,"2020":136,"2021":137,"2022":138,"2023":139},0.01,0.02,0.22,0.18,0.34,0.55,0.29,0.61,0.42,0.71,0.78,0.77,0.67,146,24,1616,{"1994":144,"1995":145,"1996":146,"1997":147,"1998":148,"1999":149,"2000":149,"2001":147,"2002":150,"2003":151,"2004":150,"2005":152,"2006":153,"2007":154,"2008":155,"2009":156,"2010":157,"2011":153,"2012":158,"2013":159,"2014":160,"2015":161,"2016":162,"2017":163,"2018":164,"2019":165,"2020":166,"2021":167,"2022":168,"2023":169,"2024":170},19,15,21,38,39,51,41,40,47,44,66,46,60,43,69,52,53,65,54,57,78,64,106,88,71,77,29,4449,{"1994":173,"1995":174,"1996":175,"1997":176,"1998":177,"1999":178,"2000":179,"2001":180,"2002":181,"2003":182,"2004":183,"2005":184,"2006":185,"2007":186,"2008":187,"2009":188,"2010":189,"2011":157,"2012":190,"2013":191,"2014":192,"2015":193,"2016":183,"2017":194,"2018":184,"2019":195,"2020":196,"2021":197,"2022":198,"2023":199,"2024":200},13,11,2,25,56,9,275,180,96,110,174,269,136,243,190,99,144,176,104,369,223,262,233,338,156,63,4,3,2.75,{"1994":203,"1995":204,"1996":205,"1997":206,"1998":207,"1999":130,"2000":208,"2001":209,"2002":210,"2003":201,"2004":211,"2005":212,"2006":213,"2007":214,"2008":215,"2009":216,"2010":217,"2011":218,"2012":219,"2013":175,"2014":220,"2015":221,"2016":222,"2017":223,"2018":224,"2019":225,"2020":226,"2021":227,"2022":228,"2023":229,"2024":205},0.68,0.73,0.1,0.66,1.44,5.39,4.74,2.34,4.24,5.72,3.09,3.68,4.13,1.65,3.35,0.98,2.55,6.96,3.43,3.22,4.6,3.45,3.64,3.19,1.77,0.89,0.05,34,"JOURNAL",{"meta":233,"data":235},{"total":234},"1620",[236,564,897,1088,1212,1368,1493,1676,1838,2090],{"id":237,"createTime":238,"updateTime":239,"relativeEntities":240,"slug":241,"properties":242,"entityType":251,"verifyStatus":252,"verifyTime":239,"verifyNote":253,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"primaryUrl":254,"fullTextUrl":22,"authors":255,"publicationType":525,"publisherRelationship":526,"citationCount":22,"citationInfo":22,"publishDate":561,"publishYear":562,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":22,"openAccess":22,"references":22,"isForceReanalyzing":563},"7a725c74-bdbe-4ce0-90c7-52d921587696","2024-02-09T14:00:52.098+00:00","2024-12-27T23:59:12.672+00:00",[],"The-efficacy-and-feasibility-of-dose-dense-sequential-chemotherapy-for-Japanese-patients-with-breast-cancer",{"references":243,"abstract":245,"title":247,"doi":249},{"VOID":244},"Hryniuk W, Levine MN. Analysis of dose intensity for adjuvant chemotherapy trials in stage II breast cancer. J Clin Oncol. 1986;4:1162–70.\nCitron ML, Berry DA, Cirrincione C, Hudis C, Winer EP, Gradishar WJ, et al. Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741\u002FCancer and Leukemia Group B Trial 9741. J Clin Oncol. 2003;21:1431–9.\nBonilla L, Ben-Aharon I, Vidal L, Gafter-Gvili A, Leibovici L, Stemmer SM. Dose-dense chemotherapy in nonmetastatic breast cancer: a systematic review and meta-analysis of randomized controlled trials. J Natl Cancer Inst. 2010;102:1845–54.\nDel Mastro L, De Placido S, Bruzzi P, De Laurentiis M, Boni C, Cavazzini G, et al. Fluorouracil and dose-dense chemotherapy in adjuvant treatment of patients with early-stage breast cancer: an open-label, 2 × 2 factorial, randomised phase 3 trial. Lancet. 2015;385:1863–72.\nBosch TM, Huitema AD, Doodeman VD, Jansen R, Witteveen E, Smit WM, et al. Pharmacogenetic screening of CYP3A and ABCB1 in relation to population pharmacokinetics of docetaxel. Clin Cancer Res. 2006;12:5786–93.\nJones S, Holmes FA, O’Shaughnessy J, Blum JL, Vukelja SJ, McIntyre KJ, et al. Docetaxel With Cyclophosphamide Is Associated With an Overall Survival Benefit Compared With Doxorubicin and Cyclophosphamide: 7-Year Follow-Up of US Oncology Research Trial 9735. J Clin Oncol. 2009;27:1177–83.\nTakabatake D, Taira N, Hara F, Sien T, Kiyoto S, Takashima S, et al. Feasibility study of docetaxel with cyclophosphamide as adjuvant chemotherapy for Japanese breast cancer patients. Jpn J Clin Oncol. 2009;39:478–83.\nKosaka Y, Rai Y, Masuda N, Takano T, Saeki T, Nakamura S, et al. Phase III placebo-controlled, double-blind, randomized trial of pegfilgrastim to reduce the risk of febrile neutropenia in breast cancer patients receiving docetaxel\u002Fcyclophosphamide chemotherapy. Support Care Cancer. 2015;23:1137–43.\nMorita S, Kikumori T, Tsunoda N, Inaishi T, Adachi Y, Ota A, et al. Feasibility of dose-dense epirubicin and cyclophosphamide with subcutaneous pegfilgrastim 3.6 mg support: a single-center prospective study in Japan. Int J Clin Oncol. 2017; 23: 195–200\nvon Minckwitz G, Untch M, Blohmer JU, Costa SD, Eidtmann H, Fasching PA, et al. Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes. J Clin Oncol. 2012;30:1796–804.\nBudd GT, Barlow WE, Moore HC, Hobday TJ, Stewart JA, Isaacs C, et al. SWOG S0221: a phase III trial comparing chemotherapy schedules in high-risk early-stage breast cancer. J Clin Oncol. 2015;33:58–64.\nToi M, Nakamura S, Kuroi K, Iwata H, Ohno S, Masuda N, et al. Phase II study of preoperative sequential FEC and docetaxel predicts of pathological response and disease free survival. Breast Cancer Res Treat. 2008;110:531–9.\nTaguchi T, Masuda N, Nakayama T, Motomura K, Tsukamoto F, Shimazu K, et al. Phase II trial in Japan of sequential administration of weekly paclitaxel followed by FEC as neoadjuvant chemotherapy for locally advanced breast cancer [KBCSG0206 trial: Kinki Breast Cancer Study Group (KBCSG)]. Oncology. 2010;78:302–8.\nIwata H, Sato N, Masuda N, Nakamura S, Yamamoto N, Kuroi K, et al. Docetaxel followed by fluorouracil\u002Fepirubicin\u002Fcyclophosphamide as neoadjuvant chemotherapy for patients with primary breast cancer. Jpn J Clin Oncol. 2011;41:867 – 75.\nBear HD, Anderson S, Smith RE, Geyer CE Jr, Mamounas EP, Fisher B, et al. Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer:National Surgical Adjuvant Breast and Bowel Project Protocol B-27. J Clin Oncol. 2006;24:2019–27.\nSikov WM, Berry DA, Perou CM, Singh B, Cirrincione CT, Tolaney SM, et al. Impact of the addition of carboplatin and\u002For bevacizumab to neoadjuvant once-per-week paclitaxel followed by dose-dense doxorubicin and cyclophosphamide on pathologic complete response rates in stage II to III triple-negative breast cancer: CALGB 40603 (Alliance). J Clin Oncol. 2015;33:13–21.\nMizuno Y, Fuchikami H, Takeda N, Iwai M, Sato K. Efficacy of reduced dose of pegfilgrastim in Japanese breast cancer patients receiving dose-dense doxorubicin and cyclophosphamide therapy. Jpn J Clin Oncol. 2017;47:1 –7.\nArshad M, Seiter K, Bilaniuk J, Qureshi A, Patil A, Ramaswamy G, et al. Side effects related to cancer treatment: CASE 2. Splenic rupture following pegfilgrastim. J Clin Oncol. 2005;23:8533–4.\nHershman D, Neugut AI, Jacobson JS, Wang J, Tsai WY, McBride R, et al. Acute myeloid leukemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy. J Natl Cancer Inst. 2007;99:196–205.\nWatring NJ, Wagner TW, Stark JJ. Spontaneous splenic rupture secondary to pegfilgrastim to prevent neutropenia in a patient with non-small-cell lung carcinoma. Am J Emerg Med. 2007;25:247–8.\nLambertini M, Bruzzi P, Poggio F, Pastorino S, Gardin G, Clavarezza M, et al. Pegfilgrastim administration after 24 or 72 or 96 h to allow dose-dense anthracycline- and taxane-based chemotherapy in breast cancer patients: a single-center experience within the GIM2 randomized phase III trial. Support Care Cancer. 2016;24:1285–94.\nLoibl S, Mueller V, von Minckwitz G, Conrad B, Koehne CH, Kremers S, et al. Comparison of pegfilgrastim on day 2 vs. day 4 as primary prophylaxis of intense dose-dense chemotherapy in patients with node-positive primary breast cancer within the prospective, multi-center GAIN study: (GBG 33). Support Care Cancer. 2011;19:1789–95.",{"EN":246},"Perioperative dose-dense chemotherapy (DDCT) with granulocyte-colony stimulating factor (G-CSF) prophylaxis is a standard treatment for patients with high-risk breast cancer. The approval of this approach in Japan led to the widespread adoption of DDCT, despite limited efficacy and safety data among Japanese patients. We evaluated the efficacy and safety of neoadjuvant DDCT for Japanese patients with breast cancer. This prospective, multicenter, phase II study evaluated 52 women with operable human epidermal growth factor receptor 2-negative breast cancer and axillary lymph node metastasis. Neoadjuvant DDCT (adriamycin plus cyclophosphamide or epirubicin plus cyclophosphamide followed by paclitaxel) was administrated every 2 weeks with G-CSF support. The study endpoints were the rates of pathological complete response (pCR), febrile neutropenia, treatment completion, toxicities, and the relative dose intensity (RDI). The pCR rate was 21.9% (9\u002F41) and the triple-negative (TN) subtype was significantly associated with a high pCR rate (triple-negative: 53.3% vs. luminal A: 7.7% and luminal B: 0%; p = 0.003). The treatment completion rate was 80.8% (42\u002F52) and the average RDI was 98.9%. Most adverse events were manageable and tolerable. Six patients (11.5%) developed febrile neutropenia. Grade 3–4 adverse events were slightly more common among older patients (57%) with a low protocol completion rate (≥ 65 years: 42.9% vs. \u003C65 years: 86.7%, p = 0.0062). The pCR rate for DDCT was similar to that of standard chemotherapy, although it was remarkably effective for the TN subtype. DDCT may be feasible for Japanese patients with breast cancer although caution is needed for older patients.",{"EN":248},"The efficacy and feasibility of dose-dense sequential chemotherapy for Japanese patients with breast cancer",{"VOID":250},"10.1007\u002Fs12282-018-0877-1","PUBLICATION","VERIFIED","Auto Verify","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs12282-018-0877-1",[256,272,290,303,318,330,346,361,374,387,404,420,435,448,460,472,485,497,512],{"id":257,"sortIndex":68,"researcher":22,"roles":258,"affiliations":260,"properties":269},"b3db5919-5370-46ce-8c9e-66a7d6dc353c",[259],"AUTHOR",[261],{"id":22,"sortIndex":23,"affiliation":262,"properties":22},{"id":263,"createTime":264,"updateTime":264,"relativeEntities":265,"slug":22,"properties":266,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"d5d221ad-f8df-4b11-8cd4-d77cc52f398e","2024-02-09T14:00:52.199+00:00",[],{"title":267},{"VI":268},"Fukuyama Citizens Hospital, Fukuyama, Japan",{"title":270},{"VI":271},"Masahiko Ikeda",{"id":273,"sortIndex":274,"researcher":22,"roles":275,"affiliations":276,"properties":287},"07631ce1-ecdb-4e2d-b69e-b907b3e8be7f",8,[259],[277],{"id":22,"sortIndex":23,"affiliation":278,"properties":22},{"id":279,"createTime":280,"updateTime":281,"relativeEntities":282,"slug":283,"properties":284,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"e17ac77f-c9b5-41cc-827b-5748826469cb","2023-12-07T15:54:48.834+00:00","2024-10-13T07:15:52.547+00:00",[],"Shikoku-Cancer-Center-Matsuyama-Japan",{"title":285},{"VI":286},"Shikoku Cancer Center, Matsuyama, Japan",{"title":288},{"VI":289},"Fumikata Hara",{"id":291,"sortIndex":292,"researcher":22,"roles":293,"affiliations":294,"properties":300},"4a36a836-d843-4aaf-b7f6-596f7aa00988",5,[259],[295],{"id":22,"sortIndex":23,"affiliation":296,"properties":22},{"id":263,"createTime":264,"updateTime":264,"relativeEntities":297,"slug":22,"properties":298,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":299},{"VI":268},{"title":301},{"VI":302},"Shinichiro Kubo",{"id":304,"sortIndex":173,"researcher":22,"roles":305,"affiliations":306,"properties":315},"3ff90225-5616-486a-8673-88dee510dd7e",[259],[307],{"id":22,"sortIndex":23,"affiliation":308,"properties":22},{"id":309,"createTime":310,"updateTime":310,"relativeEntities":311,"slug":22,"properties":312,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"e7ef2735-c45f-4309-9fc3-cb77bea9ea9a","2024-02-09T14:00:52.155+00:00",[],{"title":313},{"VI":314},"Matsue Red Cross General Hospital, Matsue, Japan",{"title":316},{"VI":317},"Hajime Hikino",{"id":319,"sortIndex":200,"researcher":22,"roles":320,"affiliations":321,"properties":327},"c712926b-3677-4bdf-a5d2-14a42c38fe5c",[259],[322],{"id":22,"sortIndex":23,"affiliation":323,"properties":22},{"id":263,"createTime":264,"updateTime":264,"relativeEntities":324,"slug":22,"properties":325,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":326},{"VI":268},{"title":328},{"VI":329},"Yoko Itano",{"id":331,"sortIndex":332,"researcher":22,"roles":333,"affiliations":334,"properties":343},"fab6c5f2-975d-42f5-a7a9-98c49572d5f3",12,[259],[335],{"id":22,"sortIndex":23,"affiliation":336,"properties":22},{"id":337,"createTime":338,"updateTime":338,"relativeEntities":339,"slug":22,"properties":340,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"e689ebdf-41d1-4da8-9512-912fdb34b5c4","2024-02-09T14:00:52.131+00:00",[],{"title":341},{"VI":342},"Okayama Saiseikai General Hospital, Okayama, Japan",{"title":344},{"VI":345},"Yoshitaka Nishiyama",{"id":347,"sortIndex":175,"researcher":22,"roles":348,"affiliations":349,"properties":358},"b6e26e4a-8256-40ba-8579-a60d7697076b",[259],[350],{"id":22,"sortIndex":23,"affiliation":351,"properties":22},{"id":352,"createTime":353,"updateTime":353,"relativeEntities":354,"slug":22,"properties":355,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"d108c3f8-17e1-494a-944d-a6bbac98c823","2024-02-09T14:00:52.112+00:00",[],{"title":356},{"VI":357},"Hiroshima Citizens Hospital, Hiroshima, Japan",{"title":359},{"VI":360},"Shoichiro Ohtani",{"id":362,"sortIndex":363,"researcher":22,"roles":364,"affiliations":365,"properties":371},"c944ec26-ff40-44dc-82ab-1ee4e411543f",10,[259],[366],{"id":22,"sortIndex":23,"affiliation":367,"properties":22},{"id":279,"createTime":280,"updateTime":281,"relativeEntities":368,"slug":283,"properties":369,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":370},{"VI":286},{"title":372},{"VI":373},"Shozo Ohsumi",{"id":375,"sortIndex":376,"researcher":22,"roles":377,"affiliations":378,"properties":384},"17443591-3eda-43df-81cd-6175ceb504c9",1,[259],[379],{"id":22,"sortIndex":23,"affiliation":380,"properties":22},{"id":352,"createTime":353,"updateTime":353,"relativeEntities":381,"slug":22,"properties":382,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":383},{"VI":357},{"title":385},{"VI":386},"Yukiko Kajiwara",{"id":388,"sortIndex":145,"researcher":22,"roles":389,"affiliations":390,"properties":401},"f8ec7185-2485-428b-ae03-3b6dac051f1e",[259],[391],{"id":22,"sortIndex":23,"affiliation":392,"properties":22},{"id":393,"createTime":394,"updateTime":395,"relativeEntities":396,"slug":397,"properties":398,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"6fbfbac9-7bac-4785-8137-7a6f628eab4a","2024-01-29T01:28:46.288+00:00","2024-10-03T19:20:53.968+00:00",[],"Okayama-University-Hospital-Okayama-Japan",{"title":399},{"VI":400},"Okayama University Hospital, Okayama, Japan",{"title":402},{"VI":403},"Yuko Takahashi",{"id":405,"sortIndex":406,"researcher":22,"roles":407,"affiliations":408,"properties":417},"33d016cb-efd0-4ccf-9e01-6a3cfadf8b5e",14,[259],[409],{"id":22,"sortIndex":23,"affiliation":410,"properties":22},{"id":411,"createTime":412,"updateTime":412,"relativeEntities":413,"slug":22,"properties":414,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"c509390e-9d3d-4f03-902c-b2207b2753e7","2023-12-31T03:51:07.196+00:00",[],{"title":415},{"VI":416},"Ehime Prefectural Central Hospital, Matsuyama, Japan",{"title":418},{"VI":419},"Kinya Matsuoka",{"id":421,"sortIndex":174,"researcher":22,"roles":422,"affiliations":423,"properties":432},"5089499f-7c8d-4454-b721-c895b4d381ab",[259],[424],{"id":22,"sortIndex":23,"affiliation":425,"properties":22},{"id":426,"createTime":427,"updateTime":427,"relativeEntities":428,"slug":22,"properties":429,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"75126b07-4f35-4494-81f7-837f40c40ad8","2024-02-09T14:00:52.250+00:00",[],{"title":430},{"VI":431},"Kagawa Prefectural Center Hospital, Takamatsu, Japan",{"title":433},{"VI":434},"Yutaka Ogasawara",{"id":436,"sortIndex":437,"researcher":22,"roles":438,"affiliations":439,"properties":445},"a299afc7-b0a4-40fb-a81f-038f8cc7c56d",17,[259],[440],{"id":22,"sortIndex":23,"affiliation":441,"properties":22},{"id":393,"createTime":394,"updateTime":395,"relativeEntities":442,"slug":397,"properties":443,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":444},{"VI":400},{"title":446},{"VI":447},"Naruto Taira",{"id":449,"sortIndex":178,"researcher":22,"roles":450,"affiliations":451,"properties":457},"9d726b9a-40ac-40f5-8f30-3b70ca2fcc3f",[259],[452],{"id":22,"sortIndex":23,"affiliation":453,"properties":22},{"id":279,"createTime":280,"updateTime":281,"relativeEntities":454,"slug":283,"properties":455,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":456},{"VI":286},{"title":458},{"VI":459},"Kenjiro Aogi",{"id":461,"sortIndex":80,"researcher":22,"roles":462,"affiliations":463,"properties":469},"90fa1ddc-c90e-4daf-a7b0-1b5fb9d368cc",[259],[464],{"id":22,"sortIndex":23,"affiliation":465,"properties":22},{"id":279,"createTime":280,"updateTime":281,"relativeEntities":466,"slug":283,"properties":467,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":468},{"VI":286},{"title":470},{"VI":471},"Mina Takahashi",{"id":473,"sortIndex":474,"researcher":22,"roles":475,"affiliations":476,"properties":482},"5a445d3d-58c7-430f-a727-fd06def71429",18,[259],[477],{"id":22,"sortIndex":23,"affiliation":478,"properties":22},{"id":393,"createTime":394,"updateTime":395,"relativeEntities":479,"slug":397,"properties":480,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":481},{"VI":400},{"title":483},{"VI":484},"Hiroyoshi Doihara",{"id":486,"sortIndex":199,"researcher":22,"roles":487,"affiliations":488,"properties":494},"9e8ed78b-c031-4683-9afb-69bed31d6b50",[259],[489],{"id":22,"sortIndex":23,"affiliation":490,"properties":22},{"id":263,"createTime":264,"updateTime":264,"relativeEntities":491,"slug":22,"properties":492,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":493},{"VI":268},{"title":495},{"VI":496},"Mari Yamamoto",{"id":498,"sortIndex":23,"researcher":22,"roles":499,"affiliations":500,"properties":509},"46a3c943-11d3-478f-a626-ed57b33b6311",[259],[501],{"id":22,"sortIndex":23,"affiliation":502,"properties":22},{"id":503,"createTime":504,"updateTime":504,"relativeEntities":505,"slug":22,"properties":506,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"534e33fb-3a25-4337-b89b-1ddac590a1d5","2024-02-09T14:00:52.122+00:00",[],{"title":507},{"VI":508},"Department of Breast surgery, Kochi Health Science Center, Kochi, Japan",{"title":510},{"VI":511},"Daisuke Takabatake",{"id":513,"sortIndex":514,"researcher":22,"roles":515,"affiliations":516,"properties":522},"9fd12662-ccdf-4039-8bf4-c184d23ecead",16,[259],[517],{"id":22,"sortIndex":23,"affiliation":518,"properties":22},{"id":393,"createTime":394,"updateTime":395,"relativeEntities":519,"slug":397,"properties":520,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":521},{"VI":400},{"title":523},{"VI":524},"Tadahiko Shien","ARTICLE",{"url":254,"publisher":527,"properties":556},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":528,"slug":10,"properties":529,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":534,"manageAffiliations":535,"indexDatabases":536,"url":22,"thumbnailPath":22,"statistic":551,"gsStatistic":22,"type":231,"analyzePriority":22},[],{"issn":530,"eissn":531,"title":532,"url":533},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},[],[],[537,544],{"id":84,"indexDatabase":538,"url":97,"indexYears":98,"academicFieldIds":543,"indexDatabaseRanking":104},{"id":86,"createTime":87,"updateTime":88,"relativeEntities":539,"label":540,"description":541,"key":94,"publicationTags":542,"standard":22},[],{"EN":91,"VI":91},{"EN":91,"VI":93},[96],[100,101,102,103],{"id":106,"indexDatabase":545,"url":121,"indexYears":22,"academicFieldIds":550,"indexDatabaseRanking":22},{"id":108,"createTime":109,"updateTime":110,"relativeEntities":546,"label":547,"description":548,"key":117,"publicationTags":549,"standard":22},[],{"EN":113,"VI":113},{"VI":115,"EN":116},[119,120],[123,124],{"impactFactor":23,"impactFactorByYear":552,"i10Index":140,"i10IndexLast5Year":141,"totalPublication":142,"totalPublicationByYear":553,"totalCitation":171,"totalCitationByYear":554,"totalCitationPerPublication":201,"totalCitationPerPublicationByYear":555,"hindexLast5Year":230,"hindex":230},{"2008":127,"2009":128,"2012":129,"2013":130,"2014":131,"2015":132,"2016":131,"2017":133,"2018":134,"2019":135,"2020":136,"2021":137,"2022":138,"2023":139},{"1994":144,"1995":145,"1996":146,"1997":147,"1998":148,"1999":149,"2000":149,"2001":147,"2002":150,"2003":151,"2004":150,"2005":152,"2006":153,"2007":154,"2008":155,"2009":156,"2010":157,"2011":153,"2012":158,"2013":159,"2014":160,"2015":161,"2016":162,"2017":163,"2018":164,"2019":165,"2020":166,"2021":167,"2022":168,"2023":169,"2024":170},{"1994":173,"1995":174,"1996":175,"1997":176,"1998":177,"1999":178,"2000":179,"2001":180,"2002":181,"2003":182,"2004":183,"2005":184,"2006":185,"2007":186,"2008":187,"2009":188,"2010":189,"2011":157,"2012":190,"2013":191,"2014":192,"2015":193,"2016":183,"2017":194,"2018":184,"2019":195,"2020":196,"2021":197,"2022":198,"2023":199,"2024":200},{"1994":203,"1995":204,"1996":205,"1997":206,"1998":207,"1999":130,"2000":208,"2001":209,"2002":210,"2003":201,"2004":211,"2005":212,"2006":213,"2007":214,"2008":215,"2009":216,"2010":217,"2011":218,"2012":219,"2013":175,"2014":220,"2015":221,"2016":222,"2017":223,"2018":224,"2019":225,"2020":226,"2021":227,"2022":228,"2023":229,"2024":205},{"volume":557,"pages":559},{"VOID":558},"25",{"VOID":560},"717-722","2018-06-11",2018,false,{"id":565,"createTime":566,"updateTime":567,"relativeEntities":568,"slug":569,"properties":570,"entityType":251,"verifyStatus":252,"verifyTime":567,"verifyNote":253,"syncStatus":21,"languages":581,"translateLanguages":22,"viewCount":23,"primaryUrl":583,"fullTextUrl":22,"authors":584,"publicationType":525,"publisherRelationship":855,"citationCount":23,"citationInfo":892,"publishDate":894,"publishYear":895,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":22,"openAccess":22,"references":896,"isForceReanalyzing":563},"5a3d383e-b372-4510-a773-88417ccd0b3c","2024-04-17T00:08:13.603+00:00","2025-02-03T23:58:12.676+00:00",[],"Correction-to-Validation-of-a-nuclear-grading-system-for-resected-stage-I-IIIA-high-risk-node-negative-invasive-breast-carcinoma-in-the-N-SAS-BC-01-trial",{"keywords":571,"openalex":572,"abstract":574,"title":575,"pm":577,"doi":579},{},{"VOID":573},"W4225262685",{},{"EN":576},"Correction to: Validation of a nuclear grading system for resected stage I–IIIA, high-risk, node-negative invasive breast carcinoma in the N·SAS-BC 01 trial",{"VOID":578},"35499664",{"VOID":580},"10.1007\u002Fs12282-022-01367-9",[582],"EN","https:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs12282-022-01367-9",[585,603,625,647,666,688,710,732,752,773,795,815,833],{"id":586,"sortIndex":174,"researcher":22,"roles":587,"affiliations":588,"properties":598},"17340e27-b192-438d-a519-028bbf93b83f",[],[589],{"id":590,"sortIndex":23,"affiliation":591,"properties":22},"9481bd03-d666-4ce8-a1c5-6870a1d5d874",{"id":592,"createTime":593,"updateTime":593,"relativeEntities":594,"slug":22,"properties":595,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"ba45604c-6198-402c-be59-eb8844ca3150","2024-02-06T04:48:50.619+00:00",[],{"title":596},{"VI":597},"Kaizuka City Hospital, Osaka, Japan",{"openalex":599,"title":601},{"VOID":600},"A5023306626",{"EN":602},"Hideo Inaji",{"id":604,"sortIndex":274,"researcher":22,"roles":605,"affiliations":606,"properties":618},"ccca27cc-8f3b-4f4f-9fdf-63d43fa65b9d",[],[607],{"id":608,"sortIndex":23,"affiliation":609,"properties":22},"637f9e3c-548d-4a88-bfd5-4ab22e97b734",{"id":610,"createTime":611,"updateTime":612,"relativeEntities":613,"slug":614,"properties":615,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"0228acf6-aae9-4031-801d-28acc6c4e277","2024-04-15T06:32:26.963+00:00","2025-06-11T15:35:11.363+00:00",[],"Hyogo-Cancer-Center-Hyogo-Japan",{"title":616},{"EN":617},"Hyogo Cancer Center, Hyogo, Japan",{"openalex":619,"orcid":621,"title":623},{"VOID":620},"A5038415411",{"VOID":622},"https:\u002F\u002Forcid.org\u002F0000-0002-0118-6447",{"EN":624},"Shintaro Takao",{"id":626,"sortIndex":363,"researcher":22,"roles":627,"affiliations":628,"properties":640},"ebf17fa5-3f6d-46c6-941a-be3aa0d016eb",[],[629],{"id":630,"sortIndex":23,"affiliation":631,"properties":22},"9129c6aa-58f9-4b68-b472-70c4792deb46",{"id":632,"createTime":633,"updateTime":634,"relativeEntities":635,"slug":636,"properties":637,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"967c732f-8c55-4440-83b6-8fc1b148935b","2023-12-29T11:45:49.383+00:00","2024-10-13T22:25:07.045+00:00",[],"Tokai-University-School-of-Medicine-Kanagawa-Japan",{"title":638},{"VI":639},"Tokai University School of Medicine, Kanagawa, Japan",{"openalex":641,"orcid":643,"title":645},{"VOID":642},"A5074835392",{"VOID":644},"https:\u002F\u002Forcid.org\u002F0000-0003-4641-2513",{"EN":646},"Yutaka Tokuda",{"id":648,"sortIndex":175,"researcher":22,"roles":649,"affiliations":650,"properties":661},"9b5c5008-6bde-43f3-8f15-d3cdb5ea53e4",[],[651],{"id":652,"sortIndex":23,"affiliation":653,"properties":22},"6cd183b6-bc30-48e7-9ce6-aaa425462d33",{"id":654,"createTime":655,"updateTime":655,"relativeEntities":656,"slug":657,"properties":658,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"a6d426bb-0855-49fa-923c-6a00ce19c1c3","2024-04-15T06:32:26.904+00:00",[],"Cancer-Institute-of-the-Japanese-Foundation-for-Cancer-Research-Tokyo-Japan",{"title":659},{"EN":660},"Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo, Japan",{"openalex":662,"title":664},{"VOID":663},"A5003489811",{"EN":665},"Futoshi Akiyama",{"id":667,"sortIndex":292,"researcher":22,"roles":668,"affiliations":669,"properties":681},"b58488eb-7eef-4773-8db5-45faf42ebacc",[],[670],{"id":671,"sortIndex":23,"affiliation":672,"properties":22},"c63f1a0f-cf1f-42d4-9dc5-72f45e6cee3c",{"id":673,"createTime":674,"updateTime":675,"relativeEntities":676,"slug":677,"properties":678,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"9b9d6925-4893-47fc-b84b-724f38562049","2023-12-05T13:07:47.081+00:00","2024-10-14T10:47:08.125+00:00",[],"Nagoya-University-Graduate-School-of-Medicine-Nagoya-Japan",{"title":679},{"VI":680},"Nagoya University Graduate School of Medicine, Nagoya, Japan",{"openalex":682,"orcid":684,"title":686},{"VOID":683},"A5067189124",{"VOID":685},"https:\u002F\u002Forcid.org\u002F0000-0002-7302-0278",{"EN":687},"Norikazu Masuda",{"id":689,"sortIndex":80,"researcher":22,"roles":690,"affiliations":691,"properties":703},"cc06239c-97c5-4d84-8926-25180e28021b",[],[692],{"id":693,"sortIndex":23,"affiliation":694,"properties":22},"e9d24bb1-a904-48dc-961b-8ca57ed9c4c5",{"id":695,"createTime":696,"updateTime":697,"relativeEntities":698,"slug":699,"properties":700,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"d56db60e-8198-4388-a016-c1da50baae44","2024-01-27T14:46:03.754+00:00","2024-10-08T06:03:21.178+00:00",[],"Niigata-Cancer-Center-Hospital-Niigata-Japan",{"title":701},{"VI":702},"Niigata Cancer Center Hospital, Niigata, Japan",{"openalex":704,"orcid":706,"title":708},{"VOID":705},"A5060702089",{"VOID":707},"https:\u002F\u002Forcid.org\u002F0000-0002-3804-9382",{"EN":709},"Nobuaki Sato",{"id":711,"sortIndex":199,"researcher":22,"roles":712,"affiliations":713,"properties":725},"bf48edf7-9db2-490e-afca-e903850c91da",[],[714],{"id":715,"sortIndex":23,"affiliation":716,"properties":22},"bd3be9fa-5a78-479e-9fd9-aed04db1684d",{"id":717,"createTime":718,"updateTime":719,"relativeEntities":720,"slug":721,"properties":722,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"53ef2820-6f66-4437-b426-5217980736fb","2024-01-04T10:23:19.510+00:00","2024-12-14T07:08:47.331+00:00",[],"Fukushima-Medical-University-Fukushima-Japan",{"title":723},{"VI":724},"Fukushima Medical University, Fukushima, Japan",{"openalex":726,"orcid":728,"title":730},{"VOID":727},"A5036168618",{"VOID":729},"https:\u002F\u002Forcid.org\u002F0000-0002-6732-8030",{"EN":731},"Shigehira Saji",{"id":733,"sortIndex":376,"researcher":22,"roles":734,"affiliations":735,"properties":747},"c498ac2b-5cd7-4049-b732-55b3b7a2ab2d",[],[736],{"id":737,"sortIndex":23,"affiliation":738,"properties":22},"71f8326d-85b7-4ba1-bb9c-7f2391dbea45",{"id":739,"createTime":740,"updateTime":741,"relativeEntities":742,"slug":743,"properties":744,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"b5bb931c-7771-450a-a19f-14d388e1f6d6","2024-02-07T09:26:43.313+00:00","2024-09-13T07:14:36.932+00:00",[],"Kameda-Medical-Center-Chiba-Japan",{"title":745},{"VI":746},"Kameda Medical Center, Chiba, Japan",{"openalex":748,"title":750},{"VOID":749},"A5058163170",{"EN":751},"Masafumi Kurosumi",{"id":753,"sortIndex":200,"researcher":22,"roles":754,"affiliations":755,"properties":766},"f43a9b2a-817a-43a2-a3f1-73cf355a0608",[],[756],{"id":757,"sortIndex":23,"affiliation":758,"properties":22},"f8080e3f-9ce3-45c0-97db-55f447680bda",{"id":759,"createTime":760,"updateTime":760,"relativeEntities":761,"slug":762,"properties":763,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"6e9d5eee-f675-4b56-805e-23dfbb7c9fcc","2024-04-11T20:14:03.580+00:00",[],"Cancer-Institute-Hospital-of-Japanese-Foundation-for-Cancer-Research-Tokyo-Japan",{"title":764},{"EN":765},"Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan",{"openalex":767,"orcid":769,"title":771},{"VOID":768},"A5056628460",{"VOID":770},"https:\u002F\u002Forcid.org\u002F0000-0003-2093-3353",{"EN":772},"Shinji Ohno",{"id":774,"sortIndex":23,"researcher":22,"roles":775,"affiliations":776,"properties":788},"9d4aca30-2b71-4b4d-a032-54b0bef1e60c",[],[777],{"id":778,"sortIndex":23,"affiliation":779,"properties":22},"e731057b-2574-48a7-97d3-27d6a2e1154c",{"id":780,"createTime":781,"updateTime":782,"relativeEntities":783,"slug":784,"properties":785,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"17706956-ce44-48f4-a777-c1f60975bf84","2024-01-09T12:49:25.244+00:00","2025-02-09T16:33:05.299+00:00",[],"National-Defense-Medical-College-Saitama-Japan",{"title":786},{"VI":787},"National Defense Medical College. Saitama, Japan",{"openalex":789,"orcid":791,"title":793},{"VOID":790},"A5063851467",{"VOID":792},"https:\u002F\u002Forcid.org\u002F0000-0003-3457-4224",{"EN":794},"Hitoshi Tsuda",{"id":796,"sortIndex":332,"researcher":22,"roles":797,"affiliations":798,"properties":810},"ef398a7a-f590-4963-aa0a-c205eaf3300f",[],[799],{"id":800,"sortIndex":23,"affiliation":801,"properties":22},"28bfc65d-d9b9-4d0c-8fb5-ed25abd3018e",{"id":802,"createTime":803,"updateTime":804,"relativeEntities":805,"slug":806,"properties":807,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"0c49fb2c-6be9-4652-99bb-58072f20567a","2024-04-11T20:14:03.625+00:00","2025-06-12T01:07:02.137+00:00",[],"Hamamatsu-Oncology-Center-Shizuoka-Japan",{"title":808},{"EN":809},"Hamamatsu Oncology Center, Shizuoka, Japan",{"openalex":811,"title":813},{"VOID":812},"A5024457348",{"EN":814},"Toru Watanabe",{"id":816,"sortIndex":178,"researcher":22,"roles":817,"affiliations":818,"properties":829},"00d9d5e5-7317-42ec-9cc8-90f52de16b11",[],[819],{"id":820,"sortIndex":23,"affiliation":821,"properties":22},"1fd3d69f-b5c1-472e-8c36-4dd4ed60b267",{"id":822,"createTime":823,"updateTime":823,"relativeEntities":824,"slug":825,"properties":826,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"fdd6be3d-e8e5-4e83-9821-c308c5c9826a","2024-04-17T00:08:13.717+00:00",[],"NHO-Shikoku-Cancer-Center-Ehime-Japan",{"title":827},{"EN":828},"NHO Shikoku Cancer Center, Ehime, Japan",{"openalex":830,"title":832},{"VOID":831},"A5064840940",{"EN":373},{"id":834,"sortIndex":68,"researcher":22,"roles":835,"affiliations":836,"properties":848},"afdbacf7-c213-46e7-98ad-be466199bdbd",[],[837],{"id":838,"sortIndex":23,"affiliation":839,"properties":22},"b50078db-56e0-4549-94d5-1ad566282a73",{"id":840,"createTime":841,"updateTime":842,"relativeEntities":843,"slug":844,"properties":845,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"25a1f4be-4592-4dca-80bb-76baef7a439c","2024-04-21T02:25:59.345+00:00","2024-12-10T19:28:47.033+00:00",[],"National-Cancer-Center-Hospital-Tokyo-Japan",{"title":846},{"EN":847},"National Cancer Center Hospital, Tokyo, Japan",{"openalex":849,"orcid":851,"title":853},{"VOID":850},"A5017930409",{"VOID":852},"https:\u002F\u002Forcid.org\u002F0000-0002-2557-8170",{"EN":854},"Akihiko Shimomura",{"url":22,"publisher":856,"properties":885},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":857,"slug":10,"properties":858,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":863,"manageAffiliations":864,"indexDatabases":865,"url":22,"thumbnailPath":22,"statistic":880,"gsStatistic":22,"type":231,"analyzePriority":22},[],{"issn":859,"eissn":860,"title":861,"url":862},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},[],[],[866,873],{"id":84,"indexDatabase":867,"url":97,"indexYears":98,"academicFieldIds":872,"indexDatabaseRanking":104},{"id":86,"createTime":87,"updateTime":88,"relativeEntities":868,"label":869,"description":870,"key":94,"publicationTags":871,"standard":22},[],{"EN":91,"VI":91},{"EN":91,"VI":93},[96],[100,101,102,103],{"id":106,"indexDatabase":874,"url":121,"indexYears":22,"academicFieldIds":879,"indexDatabaseRanking":22},{"id":108,"createTime":109,"updateTime":110,"relativeEntities":875,"label":876,"description":877,"key":117,"publicationTags":878,"standard":22},[],{"EN":113,"VI":113},{"VI":115,"EN":116},[119,120],[123,124],{"impactFactor":23,"impactFactorByYear":881,"i10Index":140,"i10IndexLast5Year":141,"totalPublication":142,"totalPublicationByYear":882,"totalCitation":171,"totalCitationByYear":883,"totalCitationPerPublication":201,"totalCitationPerPublicationByYear":884,"hindexLast5Year":230,"hindex":230},{"2008":127,"2009":128,"2012":129,"2013":130,"2014":131,"2015":132,"2016":131,"2017":133,"2018":134,"2019":135,"2020":136,"2021":137,"2022":138,"2023":139},{"1994":144,"1995":145,"1996":146,"1997":147,"1998":148,"1999":149,"2000":149,"2001":147,"2002":150,"2003":151,"2004":150,"2005":152,"2006":153,"2007":154,"2008":155,"2009":156,"2010":157,"2011":153,"2012":158,"2013":159,"2014":160,"2015":161,"2016":162,"2017":163,"2018":164,"2019":165,"2020":166,"2021":167,"2022":168,"2023":169,"2024":170},{"1994":173,"1995":174,"1996":175,"1997":176,"1998":177,"1999":178,"2000":179,"2001":180,"2002":181,"2003":182,"2004":183,"2005":184,"2006":185,"2007":186,"2008":187,"2009":188,"2010":189,"2011":157,"2012":190,"2013":191,"2014":192,"2015":193,"2016":183,"2017":194,"2018":184,"2019":195,"2020":196,"2021":197,"2022":198,"2023":199,"2024":200},{"1994":203,"1995":204,"1996":205,"1997":206,"1998":207,"1999":130,"2000":208,"2001":209,"2002":210,"2003":201,"2004":211,"2005":212,"2006":213,"2007":214,"2008":215,"2009":216,"2010":217,"2011":218,"2012":219,"2013":175,"2014":220,"2015":221,"2016":222,"2017":223,"2018":224,"2019":225,"2020":226,"2021":227,"2022":228,"2023":229,"2024":205},{"volume":886,"pages":888,"issue":890},{"VOID":887},"29",{"VOID":889},"730-730",{"VOID":891},"4",{"total":23,"publishYear":22,"statisticByYear":893},{},"2022-07-01",2022,[],{"id":898,"createTime":899,"updateTime":899,"relativeEntities":900,"slug":22,"properties":901,"entityType":251,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"primaryUrl":910,"fullTextUrl":22,"authors":911,"publicationType":525,"publisherRelationship":1051,"citationCount":22,"citationInfo":22,"publishDate":1086,"publishYear":1087,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":22,"openAccess":22,"references":22,"isForceReanalyzing":563},"c3fe9c60-a057-4bcc-bb3f-2cb0f2fcb965","2024-01-09T23:57:44.280+00:00",[],{"references":902,"abstract":904,"title":906,"doi":908},{"VOID":903},"Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, et al. Molecular portraits of human breast tumours. Nature. 2000;406:747–52.\nLin Y, Yin W, Yan T, Zhou L, Di G, Wu J, et al. Site-specific relapse pattern of the triple negative tumors in Chinese breast cancer patients. BMC Cancer. 2009;9:342.\nGoldhirsch A, Wood WC, Coates AS, Gelber RD, Thurlimann B, Senn HJ, et al. Strategies for subtypes—dealing with the diversity of breast cancer: highlights of the St. Gallen international expert consensus on the primary therapy of early breast cancer 2011. Ann Oncol. 2011;22:1736–47.\nAurilio G, Disalvatore D, Pruneri G, Bagnardi V, Viale G, Curigliano G, et al. A meta-analysis of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 discordance between primary breast cancer and metastases. Eur J Cancer. 2014;50:277–89.\nWolff AC, Hammond ME, Hicks DG, Dowsett M, McShane LM, Allison KH, et al. Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American society of clinical oncology\u002Fcollege of american pathologists clinical practice guideline update. J Clin Oncol. 2013;31:3997–4013.\nKocjan G. Needle aspiration cytology of the breast: current perspective on the role in diagnosis and management. Acta Med Croatica. 2008;62:391–401.\nNathan NA, Narayan E, Smith MM, Horn MJ. Cell block cytology. Improved preparation and its efficacy in diagnostic cytology. Am J Clin Pathol. 2000;114:599–606.\nDaltoe RD, Madeira KP, de Carvalho AA, de Rezende LC, Silva IV, Rangel LB. Evaluation of the progesterone receptor status in breast cancer using three different antibodies: a comparison by Allred score system. Int J Clin Exp Pathol. 2014;7:331–9.\nHoefnagel LD, van der Groep P, van de Vijver MJ, Boers JE, Wesseling P, Wesseling J, et al. Discordance in ERalpha, PR and HER2 receptor status across different distant breast cancer metastases within the same patient. Ann Oncol. 2013;24:3017–23.\nHoussami N, Macaskill P, Balleine RL, Bilous M, Pegram MD. HER2 discordance between primary breast cancer and its paired metastasis: tumor biology or test artefact? Insights through meta-analysis. Breast Cancer Res Treat. 2011;129:659–74.\nKaufman PA, Bloom KJ, Burris H, Gralow JR, Mayer M, Pegram M, et al. Assessing the discordance rate between local and central HER2 testing in women with locally determined HER2-negative breast cancer. Cancer. 2014;120:2657–64.\nNishimura R, Osako T, Okumura Y, Tashima R, Toyozumi Y, Arima N. Changes in the ER, PgR, HER2, p53 and Ki-67 biological markers between primary and recurrent breast cancer: discordance rates and prognosis. World J Surg Oncol. 2011;9:131.\nYao ZX, Lu LJ, Wang RJ, Jin LB, Liu SC, Li HY, et al. Discordance and clinical significance of ER, PR, and HER2 status between primary breast cancer and synchronous axillary lymph node metastasis. Med Oncol. 2014;31:798.\nKrishnamurthy S, Bischoff F, Ann Mayer J, Wong K, Pham T, Kuerer H, et al. Discordance in HER2 gene amplification in circulating and disseminated tumor cells in patients with operable breast cancer. Cancer Med. 2013;2:226–33.\nGreco ATH. Cancer of unknown primary site. Principles and practice of oncology. 2008: 1047–1052.\nKumar SK, Gupta N, Rajwanshi A, Joshi K, Singh G. Immunochemistry for oestrogen receptor, progesterone receptor and HER2 on cell blocks in primary breast carcinoma. Cytopathology. 2011.\nSchluter B, Gerhards R, Strumberg D, Voigtmann R. Combined detection of Her2\u002Fneu gene amplification and protein overexpression in effusions from patients with breast and ovarian cancer. J Cancer Res Clin Oncol. 2010;136:1389–400.",{"EN":905},"The discordance of the hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) expressions between primary cancer and metastatic lesions is an important issue when selecting the optimal treatments for patients with metastatic breast cancer. A rebiopsy for the metastatic cancer is recommended before selecting the treatment; however, it is not easy to take a tissue sample for all metastatic lesions. Fine needle aspiration cytology (FNA) for regional lymph nodes and aspiration for pleural effusions or ascites are less invasive procedures to obtain the necessary samples to examine the HR\u002FHER2 expression. These cytologic materials are able to be stained as a tissue sample using the cell block method. We examined the HR\u002FHER2 expression of 20 patients with breast cancer (8 with synchronous metastases and 12 with metachronous metastases) using the cell block method. Among 8 patients with synchronous metastases, 7 patients with axillary lymph node (LN) metastasis were examined by fine needle aspiration (FNA), and one patient with pleural metastases was analyzed for the aspirated fluid. While in 12 patients with metachronous metastases, 7 patients were examined for their pleural effusion, 3 patients were examined for regional lymph node metastases, and 1 patient were examined for aspirated ascites. We compared the HR\u002FHER expression between primary cancer and metastatic lesion in 17 patients (5 cases of 8 synchronous metastases, and all of 12 metachronous metastases). Discordance of HR was seen in 4 of 17 patients (24 %). Three cases with axillary LN metastasis (2 cases with synchronous metastases and one with metachronous metastasis) showed negative change of ER. Negative change of HER2 expression was seen in one patient with ascites caused by peritoneal dissemination. Cytology materials are easily obtained by FNA for LN metastases and aspiration for malignant effusions and analyzed for HR\u002FHER2 expression using cell block method. We should take advantage of cell block analysis to determine the discordance of the HR\u002FHER2 expression to select the optimal treatment for metastatic breast cancer.",{"EN":907},"Benefits of using the cell block method to determine the discordance of the HR\u002FHER2 expression in patients with metastatic breast cancer",{"VOID":909},"10.1007\u002Fs12282-015-0615-x","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs12282-015-0615-x",[912,927,939,955,967,979,991,1003,1015,1027,1039],{"id":913,"sortIndex":199,"researcher":22,"roles":914,"affiliations":915,"properties":924},"900eacc9-b4b4-4fa6-a630-46ba4110995a",[259],[916],{"id":22,"sortIndex":23,"affiliation":917,"properties":22},{"id":918,"createTime":919,"updateTime":919,"relativeEntities":920,"slug":22,"properties":921,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"ab3b77c5-0c4f-49d9-802c-c80a3b17f313","2024-01-13T08:50:45.565+00:00",[],{"title":922},{"VI":923},"Department of Surgery, Yamanashi Prefectural Central Hospital, Kofu, Japan",{"title":925},{"VI":926},"Kazunori Takahashi",{"id":928,"sortIndex":200,"researcher":22,"roles":929,"affiliations":930,"properties":936},"0e570890-840a-4ba4-b283-850008139e1d",[259],[931],{"id":22,"sortIndex":23,"affiliation":932,"properties":22},{"id":918,"createTime":919,"updateTime":919,"relativeEntities":933,"slug":22,"properties":934,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":935},{"VI":923},{"title":937},{"VI":938},"Masayuki Inoue",{"id":940,"sortIndex":363,"researcher":22,"roles":941,"affiliations":942,"properties":952},"e603995b-0cc8-4924-8316-5f9d47ba602d",[259],[943],{"id":22,"sortIndex":23,"affiliation":944,"properties":22},{"id":945,"createTime":946,"updateTime":946,"relativeEntities":947,"slug":948,"properties":949,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"2e979a27-4478-40c0-ae98-90d6e1c4b8c4","2024-04-14T10:26:36.230+00:00",[],"Department-of-Pathology-Yamanashi-Prefectural-Central-Hospital-Kofu-Japan",{"title":950},{"EN":951},"Department of Pathology, Yamanashi Prefectural Central Hospital, Kofu, Japan",{"title":953},{"VI":954},"Toshio Oyama",{"id":956,"sortIndex":274,"researcher":22,"roles":957,"affiliations":958,"properties":964},"a449f270-8c6d-423b-9402-db1185e948f6",[259],[959],{"id":22,"sortIndex":23,"affiliation":960,"properties":22},{"id":945,"createTime":946,"updateTime":946,"relativeEntities":961,"slug":948,"properties":962,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":963},{"EN":951},{"title":965},{"VI":966},"Kenji Amemiya",{"id":968,"sortIndex":292,"researcher":22,"roles":969,"affiliations":970,"properties":976},"e3dec68d-bdd0-4da8-af9d-940eff56bbf2",[259],[971],{"id":22,"sortIndex":23,"affiliation":972,"properties":22},{"id":918,"createTime":919,"updateTime":919,"relativeEntities":973,"slug":22,"properties":974,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":975},{"VI":923},{"title":977},{"VI":978},"Masahiro Maruyama",{"id":980,"sortIndex":175,"researcher":22,"roles":981,"affiliations":982,"properties":988},"2b513ab2-b51e-4ed5-978f-1efda2fa37a0",[259],[983],{"id":22,"sortIndex":23,"affiliation":984,"properties":22},{"id":918,"createTime":919,"updateTime":919,"relativeEntities":985,"slug":22,"properties":986,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":987},{"VI":923},{"title":989},{"VI":990},"Masato Omori",{"id":992,"sortIndex":178,"researcher":22,"roles":993,"affiliations":994,"properties":1000},"defe225b-41ef-4c27-af58-62fc5b43111f",[259],[995],{"id":22,"sortIndex":23,"affiliation":996,"properties":22},{"id":945,"createTime":946,"updateTime":946,"relativeEntities":997,"slug":948,"properties":998,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":999},{"EN":951},{"title":1001},{"VI":1002},"Eri Ishii",{"id":1004,"sortIndex":23,"researcher":22,"roles":1005,"affiliations":1006,"properties":1012},"f9416007-d0e2-43a5-8dea-e3ceee21cae9",[259],[1007],{"id":22,"sortIndex":23,"affiliation":1008,"properties":22},{"id":918,"createTime":919,"updateTime":919,"relativeEntities":1009,"slug":22,"properties":1010,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1011},{"VI":923},{"title":1013},{"VI":1014},"Yuko Nakayama",{"id":1016,"sortIndex":376,"researcher":22,"roles":1017,"affiliations":1018,"properties":1024},"402beb33-0b71-4876-aee1-95f9a0a9515f",[259],[1019],{"id":22,"sortIndex":23,"affiliation":1020,"properties":22},{"id":918,"createTime":919,"updateTime":919,"relativeEntities":1021,"slug":22,"properties":1022,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1023},{"VI":923},{"title":1025},{"VI":1026},"Hiroshi Nakagomi",{"id":1028,"sortIndex":80,"researcher":22,"roles":1029,"affiliations":1030,"properties":1036},"3095f687-234f-4a47-8d79-0615ca7fc6ab",[259],[1031],{"id":22,"sortIndex":23,"affiliation":1032,"properties":22},{"id":918,"createTime":919,"updateTime":919,"relativeEntities":1033,"slug":22,"properties":1034,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1035},{"VI":923},{"title":1037},{"VI":1038},"Kazushige Furuya",{"id":1040,"sortIndex":68,"researcher":22,"roles":1041,"affiliations":1042,"properties":1048},"d09e61bf-1237-471e-971b-a69d30661ef8",[259],[1043],{"id":22,"sortIndex":23,"affiliation":1044,"properties":22},{"id":918,"createTime":919,"updateTime":919,"relativeEntities":1045,"slug":22,"properties":1046,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1047},{"VI":923},{"title":1049},{"VI":1050},"Atsushi Takano",{"url":910,"publisher":1052,"properties":1081},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1053,"slug":10,"properties":1054,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":1059,"manageAffiliations":1060,"indexDatabases":1061,"url":22,"thumbnailPath":22,"statistic":1076,"gsStatistic":22,"type":231,"analyzePriority":22},[],{"issn":1055,"eissn":1056,"title":1057,"url":1058},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},[],[],[1062,1069],{"id":84,"indexDatabase":1063,"url":97,"indexYears":98,"academicFieldIds":1068,"indexDatabaseRanking":104},{"id":86,"createTime":87,"updateTime":88,"relativeEntities":1064,"label":1065,"description":1066,"key":94,"publicationTags":1067,"standard":22},[],{"EN":91,"VI":91},{"EN":91,"VI":93},[96],[100,101,102,103],{"id":106,"indexDatabase":1070,"url":121,"indexYears":22,"academicFieldIds":1075,"indexDatabaseRanking":22},{"id":108,"createTime":109,"updateTime":110,"relativeEntities":1071,"label":1072,"description":1073,"key":117,"publicationTags":1074,"standard":22},[],{"EN":113,"VI":113},{"VI":115,"EN":116},[119,120],[123,124],{"impactFactor":23,"impactFactorByYear":1077,"i10Index":140,"i10IndexLast5Year":141,"totalPublication":142,"totalPublicationByYear":1078,"totalCitation":171,"totalCitationByYear":1079,"totalCitationPerPublication":201,"totalCitationPerPublicationByYear":1080,"hindexLast5Year":230,"hindex":230},{"2008":127,"2009":128,"2012":129,"2013":130,"2014":131,"2015":132,"2016":131,"2017":133,"2018":134,"2019":135,"2020":136,"2021":137,"2022":138,"2023":139},{"1994":144,"1995":145,"1996":146,"1997":147,"1998":148,"1999":149,"2000":149,"2001":147,"2002":150,"2003":151,"2004":150,"2005":152,"2006":153,"2007":154,"2008":155,"2009":156,"2010":157,"2011":153,"2012":158,"2013":159,"2014":160,"2015":161,"2016":162,"2017":163,"2018":164,"2019":165,"2020":166,"2021":167,"2022":168,"2023":169,"2024":170},{"1994":173,"1995":174,"1996":175,"1997":176,"1998":177,"1999":178,"2000":179,"2001":180,"2002":181,"2003":182,"2004":183,"2005":184,"2006":185,"2007":186,"2008":187,"2009":188,"2010":189,"2011":157,"2012":190,"2013":191,"2014":192,"2015":193,"2016":183,"2017":194,"2018":184,"2019":195,"2020":196,"2021":197,"2022":198,"2023":199,"2024":200},{"1994":203,"1995":204,"1996":205,"1997":206,"1998":207,"1999":130,"2000":208,"2001":209,"2002":210,"2003":201,"2004":211,"2005":212,"2006":213,"2007":214,"2008":215,"2009":216,"2010":217,"2011":218,"2012":219,"2013":175,"2014":220,"2015":221,"2016":222,"2017":223,"2018":224,"2019":225,"2020":226,"2021":227,"2022":228,"2023":229,"2024":205},{"volume":1082,"pages":1084},{"VOID":1083},"23",{"VOID":1085},"633-639","2015-05-13",2015,{"id":1089,"createTime":1090,"updateTime":1091,"relativeEntities":1092,"slug":1093,"properties":1094,"entityType":251,"verifyStatus":252,"verifyTime":1091,"verifyNote":253,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"primaryUrl":1103,"fullTextUrl":22,"authors":1104,"publicationType":525,"publisherRelationship":1177,"citationCount":22,"citationInfo":22,"publishDate":1210,"publishYear":1211,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":22,"openAccess":22,"references":22,"isForceReanalyzing":563},"bc2d1cc9-55a9-466d-8c88-d99080a429dc","2024-01-15T17:32:19.038+00:00","2024-12-20T23:57:35.347+00:00",[],"Association-of-molecular-subtypes-and-treatment-with-survival-in-invasive-micropapillary-breast-cancer-an-analysis-of-the-Surveillance-Epidemiology-and-End-Results-database",{"references":1095,"abstract":1097,"title":1099,"doi":1101},{"VOID":1096},"Wilkinson L, Gathani T. Understanding breast cancer as a global health concern. Br J Radiol. 2022;95:20211033.\nKashyap D, Pal D, Sharma R, Garg VK, Goel N, Koundal D, et al. Global increase in breast cancer incidence: risk factors and preventive measures. Biomed Res Int. 2022;2022:9605439.\nChen Y, Yu C, Chen D, Tang Y, Zhu K, Guo R, et al. A prognostic nomogram based on risk assessment for invasive micropapillary carcinoma of the breast after surgery. Cancer Med. 2023;12:8050–62.\nChen H, Wu K, Wang M, Wang F, Zhang M, Zhang P. Invasive micropapillary carcinoma of the breast has a better long-term survival than invasive ductal carcinoma of the breast in spite of its aggressive clinical presentations: a comparison based on large population database and case-control analysis. Cancer Med. 2017;6:2775–86.\nLimaïem F, Bouraoui S. Invasive micropapillary carcinoma: a rare and aggressive breast cancer. Pan Afr Med J. 2021;40:29.\nLi D, Zhong C, Cheng Y, Zhu N, Tan Y, Zhu L, et al. A competing nomogram to predict survival outcomes in invasive micropapillary breast cancer. J Cancer. 2019;10:6801–12.\nZhang T, Lai M, Wei Y, Zhu H, Zhu C, Guo Y, et al. Nomograms for predicting overall survival and cancer-specific survival in patients with invasive micropapillary carcinoma: Based on the SEER database. Asian J Surg. 2023;46:3734–40.\nBrasó-Maristany F, Paré L, Chic N, Martínez-Sáez O, Pascual T, Mallafré-Larrosa M, et al. Gene expression profiles of breast cancer metastasis according to organ site. Mol Oncol. 2022;16:69–87.\nRossing M, Østrup O, Majewski WW, Kinalis S, Jensen MB, Knoop A, et al. Molecular subtyping of breast cancer improves identification of both high and low risk patients. Acta Oncol (Stockholm, Sweden). 2018;57:58–66.\nFan Y, Pan X, Yang F, Liu S, Wang Z, Sun J, et al. Preoperative computed tomography radiomics analysis for predicting receptors status and Ki-67 levels in breast cancer. Am J Clin Oncol. 2022;45:526–33.\nLewis GD, Xing Y, Haque W, Patel T, Schwartz MR, Chen AC, et al. The impact of molecular status on survival outcomes for invasive micropapillary carcinoma of the breast. Breast J. 2019;25:1171–6.\nZhao Y, Li S, Yan L, Yang Z, Chai N, Qiu P, et al. Nomogram for predicting overall survival in patients with invasive micropapillary carcinoma after breast-conserving surgery: a population-based analysis. Front Surg. 2022;9:1009149.\nWang S, Zhang Y, Yin F, Wang X, Yang Z. Survival outcomes after breast-conserving therapy compared with mastectomy for patients with early-stage invasive micropapillary carcinoma of the breast: a SEER population-based study. Front Oncol. 2021;11: 741737.\nSenkus E, Kyriakides S, Ohno S, Penault-Llorca F, Poortmans P, Rutgers E, et al. Primary breast cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26(Suppl 5):v8-30.\nWu SG, Zhang WW, Sun JY, Li FY, Chen YX, He ZY. Postoperative radiotherapy for invasive micropapillary carcinoma of the breast: an analysis of Surveillance, Epidemiology, and End Results database. Cancer Manag Res. 2017;9:453–9.\nLiu R, Xiao Z, Hu D, Luo H, Yin G, Feng Y, et al. Cancer-specific survival outcome in early-stage young breast cancer: evidence from the SEER database analysis. Front Endocrinol. 2021;12: 811878.\nvan Maaren MC, de Munck L, Strobbe LJA, Sonke GS, Westenend PJ, Smidt ML, et al. Ten-year recurrence rates for breast cancer subtypes in the Netherlands: a large population-based study. Int J Cancer. 2019;144:263–72.\nValla M, Vatten LJ, Engstrøm MJ, Haugen OA, Akslen LA, Bjørngaard JH, et al. Molecular subtypes of breast cancer: long-term incidence trends and prognostic differences. Cancer Epidemiol Biomark Prev. 2016;25:1625–34.\nYao J, Jin Q, Wang XD, Zhu HJ, Ni QC. Aldehyde dehydrogenase 1 expression is correlated with poor prognosis in breast cancer. Medicine. 2017;96: e7171.\nMarie L, Braik D, Abdel-Razeq N, Abu-Fares H, Al-Thunaibat A, Abdel-Razeq H. Clinical characteristics, prognostic factors and treatment outcomes of patients with bone-only metastatic breast cancer. Cancer Manag Res. 2022;14:2519–31.\nChen PY, Cheng SH, Hung CF, Yu BL, Chen CM. Locoregional therapy in luminal-like and HER2-enriched patients with de novo stage IV breast cancer. Springerplus. 2013;2:589.\nJohansson ALV, Trewin CB, Hjerkind KV, Ellingjord-Dale M, Johannesen TB, Ursin G. Breast cancer-specific survival by clinical subtype after 7 years follow-up of young and elderly women in a nationwide cohort. Int J Cancer. 2019;144:1251–61.\nWang X, Xue Y. Analysis of prognostic factors and construction of prognostic models for invasive micropapillary carcinoma of the breast. Comput Math Methods Med. 2022;2022:1072218.\nLiu QQ, Sun HF, Yang XL, Chen MT, Liu Y, Zhao Y, et al. Survival following radiotherapy in young women with localized early-stage breast cancer according to molecular subtypes. Cancer Med. 2019;8:2840–57.\nOnitilo AA, Engel JM, Stankowski RV, Doi SA. Survival comparisons for breast conserving surgery and mastectomy revisited: community experience and the role of radiation therapy. Clin Med Res. 2015;13:65–73.\nYin L, Duan JJ, Bian XW, Yu SC. Triple-negative breast cancer molecular subtyping and treatment progress. Breast Cancer Res BCR. 2020;22:61.\nCao L, Niu Y. Triple negative breast cancer: special histological types and emerging therapeutic methods. Cancer Biol Med. 2020;17:293–306.\nYoon GY, Cha JH, Kim HH, Shin HJ, Chae EY, Choi WJ. Comparison of invasive micropapillary and invasive ductal carcinoma of the breast: a matched cohort study. Acta Radiol (Stockholm, Sweden: 1987). 2019;60:1405–13.\nSaifi O, Chahrour MA, Li Z, Hoballah J, Panoff J, Vallow LA, et al. Is breast conservation superior to mastectomy in early stage triple negative breast cancer? Breast (Edinburgh, Scotland). 2022;62:144–51.",{"EN":1098},"This study aims to examine the features, treatments, and survival of invasive micropapillary carcinoma (IMPC) according to different molecular subtypes. In this cohort study, data between 2010 and 2018 were retrospectively reviewed from the Surveillance, Epidemiology, and End Results database. Molecular subtypes were categorized into four varieties: hormone receptor (HR)+\u002FHER2− (Luminal A), HR+\u002FHER2+ (Luminal B), HR−\u002FHER2− [triple-negative (TN)], and HR−\u002FHER2+ (HER2 enriched). In this study, 1,180 IMPC patients were included, with 99 patients (8.39%) of the 1,180 patients having an overall mortality, and 53 patients (53.54%) of the 99 patients having a breast cancer-specific mortality. The follow-up duration was 40.00 (18.50, 61.00) months. TN molecular subtype was associated with worse OS and BCSS in IMPC patients. Treatment of chemotherapy, radiation, and combination therapy were associated with better survival in HR+\u002FHER2+ molecular subtype and HR+\u002FHER2− molecular subtype. However, in HR−\u002FHER2− molecular subtype, treatment of chemotherapy was associated with a poor BCSS, and treatment of radiation was not associated with OS and BCSS. Surgery treatment was not associated with survival in HR+\u002FHER2+ molecular subtype and HR+\u002FHER2− molecular subtype. However, surgery treatment of mastectomy was associated with better OS in HR−\u002FHER2− molecular subtype (P \u003C 0.05). The prognosis of IMPC was significantly influenced by different molecular subtypes. Chemotherapy and radiotherapy are beneficial in HR+\u002FHER2+ and HR+\u002FHER2− patients. However, they should be used with caution in HR−\u002FHER2− (TN) patients.",{"EN":1100},"Association of molecular subtypes and treatment with survival in invasive micropapillary breast cancer: an analysis of the Surveillance, Epidemiology, and End Results database",{"VOID":1102},"10.1007\u002Fs12282-023-01523-9","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs12282-023-01523-9",[1105,1120,1135,1150,1165],{"id":1106,"sortIndex":23,"researcher":22,"roles":1107,"affiliations":1108,"properties":1117},"d86c47b3-a95c-4ae7-bfef-5738c28e59a9",[259],[1109],{"id":22,"sortIndex":23,"affiliation":1110,"properties":22},{"id":1111,"createTime":1112,"updateTime":1112,"relativeEntities":1113,"slug":22,"properties":1114,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"965725c3-bd30-4d1b-864c-16d41403ba97","2024-01-15T17:32:19.057+00:00",[],{"title":1115},{"VI":1116},"Department of Surgical Oncology, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China",{"title":1118},{"VI":1119},"Zhenning Tang",{"id":1121,"sortIndex":376,"researcher":22,"roles":1122,"affiliations":1123,"properties":1132},"32338ec3-6a6e-4a6a-a8e8-904df6fcd8bd",[259],[1124],{"id":22,"sortIndex":23,"affiliation":1125,"properties":22},{"id":1126,"createTime":1127,"updateTime":1127,"relativeEntities":1128,"slug":22,"properties":1129,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"990081a9-15c6-410d-ab71-426d9b89ace0","2024-01-15T17:32:19.081+00:00",[],{"title":1130},{"VI":1131},"Department of Neurology, The First People’s Hospital of Yinchuan, Yinchuan, People’s Republic of China",{"title":1133},{"VI":1134},"Ling Li",{"id":1136,"sortIndex":200,"researcher":22,"roles":1137,"affiliations":1138,"properties":1147},"cdaf01ae-7827-4bf6-9d34-60f55cb5306f",[259],[1139],{"id":22,"sortIndex":23,"affiliation":1140,"properties":22},{"id":1141,"createTime":1142,"updateTime":1142,"relativeEntities":1143,"slug":22,"properties":1144,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"2ca25aa7-f69e-4ee0-aebb-e1facb8d5cda","2024-01-08T23:30:49.708+00:00",[],{"title":1145},{"VI":1146},"Ningxia Medical University, Yinchuan, People’s Republic of China",{"title":1148},{"VI":1149},"Yinbing Zhao",{"id":1151,"sortIndex":199,"researcher":22,"roles":1152,"affiliations":1153,"properties":1162},"b2be76f7-e030-4e4e-9f7d-f5720e8ea6c8",[259],[1154],{"id":22,"sortIndex":23,"affiliation":1155,"properties":22},{"id":1156,"createTime":1157,"updateTime":1157,"relativeEntities":1158,"slug":22,"properties":1159,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"2a8581ec-196a-4419-ba0d-f3b34705cafb","2023-12-14T11:54:51.466+00:00",[],{"title":1160},{"VI":1161},"Department of Pathology, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China",{"title":1163},{"VI":1164},"Lingyan Huang",{"id":1166,"sortIndex":175,"researcher":22,"roles":1167,"affiliations":1168,"properties":1174},"849a9a80-60da-4397-bdd3-afa6e2891d59",[259],[1169],{"id":22,"sortIndex":23,"affiliation":1170,"properties":22},{"id":1141,"createTime":1142,"updateTime":1142,"relativeEntities":1171,"slug":22,"properties":1172,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1173},{"VI":1146},{"title":1175},{"VI":1176},"Xiaoying Huang",{"url":1103,"publisher":1178,"properties":1207},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1179,"slug":10,"properties":1180,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":1185,"manageAffiliations":1186,"indexDatabases":1187,"url":22,"thumbnailPath":22,"statistic":1202,"gsStatistic":22,"type":231,"analyzePriority":22},[],{"issn":1181,"eissn":1182,"title":1183,"url":1184},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},[],[],[1188,1195],{"id":84,"indexDatabase":1189,"url":97,"indexYears":98,"academicFieldIds":1194,"indexDatabaseRanking":104},{"id":86,"createTime":87,"updateTime":88,"relativeEntities":1190,"label":1191,"description":1192,"key":94,"publicationTags":1193,"standard":22},[],{"EN":91,"VI":91},{"EN":91,"VI":93},[96],[100,101,102,103],{"id":106,"indexDatabase":1196,"url":121,"indexYears":22,"academicFieldIds":1201,"indexDatabaseRanking":22},{"id":108,"createTime":109,"updateTime":110,"relativeEntities":1197,"label":1198,"description":1199,"key":117,"publicationTags":1200,"standard":22},[],{"EN":113,"VI":113},{"VI":115,"EN":116},[119,120],[123,124],{"impactFactor":23,"impactFactorByYear":1203,"i10Index":140,"i10IndexLast5Year":141,"totalPublication":142,"totalPublicationByYear":1204,"totalCitation":171,"totalCitationByYear":1205,"totalCitationPerPublication":201,"totalCitationPerPublicationByYear":1206,"hindexLast5Year":230,"hindex":230},{"2008":127,"2009":128,"2012":129,"2013":130,"2014":131,"2015":132,"2016":131,"2017":133,"2018":134,"2019":135,"2020":136,"2021":137,"2022":138,"2023":139},{"1994":144,"1995":145,"1996":146,"1997":147,"1998":148,"1999":149,"2000":149,"2001":147,"2002":150,"2003":151,"2004":150,"2005":152,"2006":153,"2007":154,"2008":155,"2009":156,"2010":157,"2011":153,"2012":158,"2013":159,"2014":160,"2015":161,"2016":162,"2017":163,"2018":164,"2019":165,"2020":166,"2021":167,"2022":168,"2023":169,"2024":170},{"1994":173,"1995":174,"1996":175,"1997":176,"1998":177,"1999":178,"2000":179,"2001":180,"2002":181,"2003":182,"2004":183,"2005":184,"2006":185,"2007":186,"2008":187,"2009":188,"2010":189,"2011":157,"2012":190,"2013":191,"2014":192,"2015":193,"2016":183,"2017":194,"2018":184,"2019":195,"2020":196,"2021":197,"2022":198,"2023":199,"2024":200},{"1994":203,"1995":204,"1996":205,"1997":206,"1998":207,"1999":130,"2000":208,"2001":209,"2002":210,"2003":201,"2004":211,"2005":212,"2006":213,"2007":214,"2008":215,"2009":216,"2010":217,"2011":218,"2012":219,"2013":175,"2014":220,"2015":221,"2016":222,"2017":223,"2018":224,"2019":225,"2020":226,"2021":227,"2022":228,"2023":229,"2024":205},{"pages":1208},{"VOID":1209},"1-12","2023-12-03",2023,{"id":1213,"createTime":1214,"updateTime":1215,"relativeEntities":1216,"slug":1217,"properties":1218,"entityType":251,"verifyStatus":252,"verifyTime":1215,"verifyNote":253,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"primaryUrl":1227,"fullTextUrl":22,"authors":1228,"publicationType":525,"publisherRelationship":1331,"citationCount":22,"citationInfo":22,"publishDate":1366,"publishYear":1367,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":22,"openAccess":22,"references":22,"isForceReanalyzing":563},"b78f0a34-d668-49d4-b19c-ad63b6d4e72f","2024-02-21T22:30:30.024+00:00","2025-02-20T23:57:13.119+00:00",[],"Sentinel-lymph-node-biopsy-in-patients-with-breast-cancer-using-superparamagnetic-iron-oxide-and-a-magnetometer",{"references":1219,"abstract":1221,"title":1223,"doi":1225},{"VOID":1220},"Krag DN, Weaver DL, Alex JC, Fairbank JT. Surgical resection and radiolocalization of the sentinel lymph node in breast cancer using a gamma probe. Surg Oncol. 1993;2:335–9.\nGiuliano AE, Kirgan DM, Guenther JM, Morton DL. Lymphatic mapping and sentinel lymphadenectomy for breast cancer. Ann Surg. 1994;220:391–8.\nCody HS. Sentinel lymph node mapping in breast cancer. Breast Cancer. 1999;6:13–22.\nAlbertini JJ, Lyman GH, Cox C, Yeatman T, Balducci L, Ku N, et al. Lymphatic mapping and sentinel node biopsy in the patient with breast cancer. JAMA. 1996;276:1818–22.\nDerossis AM, Fey J, Yeung H, Yeh SD, Heerdt AS, Petrek J, et al. A trend analysis of the relative value of blue dye and isotope localization in 2,000 consecutive cases of sentinel node biopsy for breast cancer. J Am Coll Surg. 2001;193:473–8.\nRadovanovic Z, Golubovic A, Plzak A, Stojiljkovic B, Radovanovic D. Blue dye versus combined blue dye-radioactive tracer technique in detection of sentinel lymph node in breast cancer. Eur J Surg Oncol. 2004;30:913–7.\nMotomura K, Inaji H, Komoike Y, Hasegawa Y, Kasugai T, Noguchi S, et al. Combination technique is superior to dye alone in identification of the sentinel node in breast cancer patients. J Surg Oncol. 2001;76:95–9.\nKrag DN, Anderson SJ, Julian TB, Brown AM, Harlow SP, Ashikaga T, et al. Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomized phase III trial. Lancet Oncol. 2007;8:881–8.\nDale PS, Williams JT IV. Axillary staging utilizing selective sentinel lymphadenectomy for patients with invasive breast carcinoma. Am Surg. 1998;64:28–31.\nGuenther JM, Krishnamoorthy M, Tan LR. Sentinel lymphadenectomy for breast cancer in a community managed care setting. Cancer J Sci Am. 1997;3:336–40.\nGrube BJ, Giuliano AE. Observation of the breast cancer patient with a tumor-positive sentinel node: implications of the ACOSOG Z0011 trial. Semin Surg Oncol. 2001;20:230–7.\nMiner TJ, Shriver CD, Flicek PR, Miner FC, Jaques DP, Maniscalco-Theberge ME, et al. Guidelines for the safe use of radioactive materials during localization and resection of the sentinel lymph node. Ann Surg Oncol. 1999;6:75–82.\nOmoto K, Hozumi Y, Omoto Y, Taniguchi N, Itoh K, Fujii Y, et al. Sentinel node detection in breast cancer using contrast-enhanced sonography with 25% albumin—initial clinical experience. J Clin Ultrasound. 2006;34:317–26.\nKitai T, Inomoto T, Miwa M, Shikayama T. Fluorescence navigation with indocyanine green for detecting sentinel lymph nodes in breast cancer. Breast Cancer. 2005;12:211–5.\nWeissleder R, Elizondo G, Wittenberg J, Lee AS, Josephson L, Brady TJ. Ultrasmall superparamagnetic iron oxide: an intravenous contrast agent for assessing lymph nodes with MR imaging. Radiology. 1990;175:494–8.\nWeissleder R, Elizondo G, Wittenberg J, Rabito CA, Bengele HH, Josephson L. Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging. Radiology. 1990;175:489–93.\nMichel SC, Keller TM, Frohlich JM, Fink D, Caduff R, Seifert B, et al. Preoperative breast cancer staging: MR imaging of the axilla with ultrasmall superparamagnetic iron oxide enhancement. Radiology. 2002;225:527–36.\nFerrucci JT, Stark DD. Iron oxide-enhanced MR imaging of the liver and spleen: review of the first 5 years. AJR Am J Roentgenol. 1990;155:943–50.\nNakagawa T, Minamiya Y, Katayose Y, Saito H, Taguchi K, Imano H, et al. A novel method for sentinel lymph node mapping using magnetite in patients with non-small cell lung cancer. J Thorac Cardiovasc Surg. 2003;126:563–7.\nMinamiya Y, Ito M, Katayose Y, Saito H, Imai K, Sato Y, et al. Intraoperative sentinel lymph node mapping using a new sterilizable magnetometer in patients with nonsmall cell lung cancer. Ann Thorac Surg. 2006;81:327–30.\nIshiyama K, Sashi R, Katayose Y, Tomura N, Watarai J, Narita K. Sentinel lymph node after intramammary injection of superparamagnetic iron oxide (article in Japanese). Nippon Igaku Hoshasen Gakkai Zasshi. 2002;62:744–6.",{"EN":1222},"Some hospitals lack facilities for radioisotopes in sentinel node biopsy. A novel method is used with a superparamagnetic tracer and a magnetometer instead of a radioisotope. Thirty patients were included in the study after obtaining IRB approval. Superparamagnetic iron oxide and patent blue dye were injected in the subareolar breast tissue. Following a few minutes of massage to promote migration of the iron tracer and blue dye throughout the lymphatic vessels, the axillary lymph nodes were detected transdermally using a handheld magnetometer and followed by standard axillary dissection in all patients. Of 30 patients evaluated, sentinel lymph nodes were identified in 90% (27\u002F30) using both blue dye and magnetic tracer. Sentinel lymph nodes were identified using the magnetic method in 23\u002F30 (77%) and blue dye in 24\u002F30 (80%). There was one false-negative sentinel node, resulting in an overall sensitivity of 6\u002F7 (86%). This is the first study to use a magnetic tracer to identify sentinel lymph nodes in patients with breast cancer. This new technique may alter the role of radioisotopes with further refinement and experience.",{"EN":1224},"Sentinel lymph node biopsy in patients with breast cancer using superparamagnetic iron oxide and a magnetometer",{"VOID":1226},"10.1007\u002Fs12282-011-0327-9","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs12282-011-0327-9",[1229,1246,1261,1276,1288,1307,1319],{"id":1230,"sortIndex":376,"researcher":22,"roles":1231,"affiliations":1232,"properties":1243},"fb6fd8ba-327c-498b-a056-3aefe0a36a5a",[259],[1233],{"id":22,"sortIndex":23,"affiliation":1234,"properties":22},{"id":1235,"createTime":1236,"updateTime":1237,"relativeEntities":1238,"slug":1239,"properties":1240,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"89707450-5378-4308-bf1b-3f0e159dfbfc","2023-12-06T01:20:29.739+00:00","2024-11-29T10:49:58.746+00:00",[],"Department-of-Surgery-Jichi-Medical-University-Shimotsuke-Japan",{"title":1241},{"VI":1242},"Department of Surgery, Jichi Medical University, Shimotsuke, Japan",{"title":1244},{"VI":1245},"Alan T. Lefor",{"id":1247,"sortIndex":200,"researcher":22,"roles":1248,"affiliations":1249,"properties":1258},"8a5dc763-92e5-4d26-8b25-625473a9f0ab",[259],[1250],{"id":22,"sortIndex":23,"affiliation":1251,"properties":22},{"id":1252,"createTime":1253,"updateTime":1253,"relativeEntities":1254,"slug":22,"properties":1255,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"fd9ceafa-f486-4eaf-b316-407152bdbdbb","2024-02-21T22:30:30.109+00:00",[],{"title":1256},{"VI":1257},"Department of Surgery, Oyama Municipal Hospital, Oyama, Japan",{"title":1259},{"VI":1260},"Katsumi Kurihara",{"id":1262,"sortIndex":68,"researcher":22,"roles":1263,"affiliations":1264,"properties":1273},"9d405c70-71cf-4eb5-ae63-0fc7aad56a3a",[259],[1265],{"id":22,"sortIndex":23,"affiliation":1266,"properties":22},{"id":1267,"createTime":1268,"updateTime":1268,"relativeEntities":1269,"slug":22,"properties":1270,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"7763e802-62c3-405f-9e3a-7975945346c7","2024-02-21T22:30:30.157+00:00",[],{"title":1271},{"VI":1272},"Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan",{"title":1274},{"VI":1275},"Moriaki Kusakabe",{"id":1277,"sortIndex":292,"researcher":22,"roles":1278,"affiliations":1279,"properties":1285},"eacd1555-ef89-4930-aeab-71420bb76e6d",[259],[1280],{"id":22,"sortIndex":23,"affiliation":1281,"properties":22},{"id":1235,"createTime":1236,"updateTime":1237,"relativeEntities":1282,"slug":1239,"properties":1283,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1284},{"VI":1242},{"title":1286},{"VI":1287},"Yoshikazu Yasuda",{"id":1289,"sortIndex":23,"researcher":22,"roles":1290,"affiliations":1291,"properties":1304},"6a0da135-0620-49f3-983b-a957ed033ae7",[259],[1292,1297],{"id":22,"sortIndex":23,"affiliation":1293,"properties":22},{"id":1252,"createTime":1253,"updateTime":1253,"relativeEntities":1294,"slug":22,"properties":1295,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1296},{"VI":1257},{"id":1298,"sortIndex":376,"affiliation":1299,"properties":1303},"8d210113-d025-4b0f-9527-64ad02232e65",{"id":1235,"createTime":1236,"updateTime":1237,"relativeEntities":1300,"slug":1239,"properties":1301,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1302},{"VI":1242},{},{"title":1305},{"VI":1306},"Mikio Shiozawa",{"id":1308,"sortIndex":199,"researcher":22,"roles":1309,"affiliations":1310,"properties":1316},"6de464b7-d7b4-4397-896c-648880eb9df1",[259],[1311],{"id":22,"sortIndex":23,"affiliation":1312,"properties":22},{"id":1235,"createTime":1236,"updateTime":1237,"relativeEntities":1313,"slug":1239,"properties":1314,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1315},{"VI":1242},{"title":1317},{"VI":1318},"Naohiro Sata",{"id":1320,"sortIndex":175,"researcher":22,"roles":1321,"affiliations":1322,"properties":1328},"b3da5c62-ad53-47d0-98eb-f776327bafaa",[259],[1323],{"id":22,"sortIndex":23,"affiliation":1324,"properties":22},{"id":1235,"createTime":1236,"updateTime":1237,"relativeEntities":1325,"slug":1239,"properties":1326,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1327},{"VI":1242},{"title":1329},{"VI":1330},"Yasuo Hozumi",{"url":1227,"publisher":1332,"properties":1361},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1333,"slug":10,"properties":1334,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":1339,"manageAffiliations":1340,"indexDatabases":1341,"url":22,"thumbnailPath":22,"statistic":1356,"gsStatistic":22,"type":231,"analyzePriority":22},[],{"issn":1335,"eissn":1336,"title":1337,"url":1338},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},[],[],[1342,1349],{"id":84,"indexDatabase":1343,"url":97,"indexYears":98,"academicFieldIds":1348,"indexDatabaseRanking":104},{"id":86,"createTime":87,"updateTime":88,"relativeEntities":1344,"label":1345,"description":1346,"key":94,"publicationTags":1347,"standard":22},[],{"EN":91,"VI":91},{"EN":91,"VI":93},[96],[100,101,102,103],{"id":106,"indexDatabase":1350,"url":121,"indexYears":22,"academicFieldIds":1355,"indexDatabaseRanking":22},{"id":108,"createTime":109,"updateTime":110,"relativeEntities":1351,"label":1352,"description":1353,"key":117,"publicationTags":1354,"standard":22},[],{"EN":113,"VI":113},{"VI":115,"EN":116},[119,120],[123,124],{"impactFactor":23,"impactFactorByYear":1357,"i10Index":140,"i10IndexLast5Year":141,"totalPublication":142,"totalPublicationByYear":1358,"totalCitation":171,"totalCitationByYear":1359,"totalCitationPerPublication":201,"totalCitationPerPublicationByYear":1360,"hindexLast5Year":230,"hindex":230},{"2008":127,"2009":128,"2012":129,"2013":130,"2014":131,"2015":132,"2016":131,"2017":133,"2018":134,"2019":135,"2020":136,"2021":137,"2022":138,"2023":139},{"1994":144,"1995":145,"1996":146,"1997":147,"1998":148,"1999":149,"2000":149,"2001":147,"2002":150,"2003":151,"2004":150,"2005":152,"2006":153,"2007":154,"2008":155,"2009":156,"2010":157,"2011":153,"2012":158,"2013":159,"2014":160,"2015":161,"2016":162,"2017":163,"2018":164,"2019":165,"2020":166,"2021":167,"2022":168,"2023":169,"2024":170},{"1994":173,"1995":174,"1996":175,"1997":176,"1998":177,"1999":178,"2000":179,"2001":180,"2002":181,"2003":182,"2004":183,"2005":184,"2006":185,"2007":186,"2008":187,"2009":188,"2010":189,"2011":157,"2012":190,"2013":191,"2014":192,"2015":193,"2016":183,"2017":194,"2018":184,"2019":195,"2020":196,"2021":197,"2022":198,"2023":199,"2024":200},{"1994":203,"1995":204,"1996":205,"1997":206,"1998":207,"1999":130,"2000":208,"2001":209,"2002":210,"2003":201,"2004":211,"2005":212,"2006":213,"2007":214,"2008":215,"2009":216,"2010":217,"2011":218,"2012":219,"2013":175,"2014":220,"2015":221,"2016":222,"2017":223,"2018":224,"2019":225,"2020":226,"2021":227,"2022":228,"2023":229,"2024":205},{"volume":1362,"pages":1364},{"VOID":1363},"20",{"VOID":1365},"223-229","2012-01-13",2012,{"id":1369,"createTime":1370,"updateTime":1371,"relativeEntities":1372,"slug":1373,"properties":1374,"entityType":251,"verifyStatus":252,"verifyTime":1371,"verifyNote":253,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"primaryUrl":1383,"fullTextUrl":22,"authors":1384,"publicationType":525,"publisherRelationship":1456,"citationCount":22,"citationInfo":22,"publishDate":1491,"publishYear":1492,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":22,"openAccess":22,"references":22,"isForceReanalyzing":563},"1a7b0c30-001b-4853-a64b-2c3c8698a4d5","2024-01-09T16:48:23.552+00:00","2025-02-01T23:56:54.911+00:00",[],"Morphological-characteristics-of-basal-like-subtype-of-breast-carcinoma-with-special-reference-to-cytopathological-features",{"references":1375,"abstract":1377,"title":1379,"doi":1381},{"VOID":1376},"Perou CM, Sorlie T, Eisen MB, Rijn M, Jeffey SS, Rees CA, et al. Molecular portraits of human breast tumours. Nature. 2000;406:747–52.\nSorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 2001;98:10869–74.\nCarey LA, Perou CM, Livasy CA, Dressler LG, Cowan D, Conway K, et al. Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA. 2006;295:2492–502.\nRakha EA, Reis-Filho JS, Ellis O. Basal-like breast cancer: a critical review. J Clin Oncol. 2008;26:2568–81.\nHicks DG, Short SM, Prescott NL, Tarr SM, Coleman KA, Yoder BJ, et al. Breast cancers with brain metastases are more likely to be estrogen receptor negative, express the basal cytokeratin CK5\u002F6, and overexpress HER2 or EGFR. Am J Surg Pathol. 2006;30:1097–104.\nTsuda H, Takarabe T, Hasegawa F, Fukutomi T, Hirohashi S. Central acellular zone indicating myoepithelial tumor differentiation in high-grade invasive ductal carcinomas as markers of predisposition to lung and brain metastases. Am J Surg Pathol. 2000;24:197–202.\nRouzier R, Perou CM, Symmans WF, Ibrahim N, Cristofanilli M, Anderson K, et al. Breast cancer molecular subtypes respond differently to preoperative chemotherapy. Clin Cancer Res. 2005;11:5678–85.\nCarey LA, Dees EC, Sawyer L, Gatti L, Noor DT, Collichio F, et al. The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes. Clin Cancer Res. 2007;13:2329–34.\nLiedtke C, Mazouni C, Hess KR, Andre F, Tordai A, Mejia JA, et al. Response to neoadjuvant therapy and long term survival in patients with triple-negative breast cancer. J Clin Oncol. 2008;26:1275–81.\nRakha EA, Putti TC, et al. Morphological and immunophenotypic analysis of breast carcinomas with basal and myoepithelial differentiation. J Pathol. 2006;208:495–506.\nFoulkes WD, Stefansson IM, Chappuis PO, Begin LR, Goffin JR, Wong N, et al. Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer. J Natl Cancer Inst. 2003;95:1482–5.\nLivasy CA, Karaca G, Nanda R, Tretiakova MS, Olopade OI, Moore DT, et al. Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma. Mod Pathol. 2006;19:264–71.\nNielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z, et al. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast cancer. Clin Cancer Res. 2004;10:5367–74.\nCheang MCU, Voduc D, Bajdik C, Leung S, McKinney S, Chia SK, et al. Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype. Clin Cancer Res. 2008;14:1368–76.\nKreike B, van Kouwenhove M, Horlings H, Weigelt B, Peterse H, Bartelink H, et al. Gene expression profiling and histopathological characterization of triple-negative\u002Fbasal-like breast carcinomas. Breast Cancer Res. 2007;9:R65.\nKurebayashi J, Moriya T, Ishida T, Hirakawa H, Kurosumi M, Akiyama F, et al. The prevalence of intrinsic subtypes and prognosis in breast cancer patients of different races. The Breast. 2007;16:s72–7.\nElston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology. 1991;19:403–10.\nTsuda H, Takarabe T, Hasegawa T, Murata T, Hirohashi S. Myoepithelial differentiation in high-grade invasive ductal carcinomas with large central acellular zones. Hum Pathol. 1999;30:1134–9.\nFulford LG, Easton DF, Reis-Filho JS, Sofronis A, Gillet CE, Lakhani SR, et al. Specific morphological features predictive for the basal phenotype in grade 3 invasive ductal carcinoma of breast. Histopathology. 2006;49:22–34.\nJacquemier J, Padovani L, Rabayrol L, Lakhani SR, Penault-Liorca F, Denoux Y, et al. Typical medullary breast carcinomas have a basal\u002Fmyoepithelial phenotype. J Pathol. 2005;207:260–8.\nTot T. The cytokeratin profile of medullary carcinoma of the breast. Histopathology. 2000;37:175–81.\nReis-Filho JS, Milanezi F, Steele D, Savage K, Simpson PT, Nesland JM, et al. Metaplastic breast carcinomas are basal-like tumours. Histopathology. 2006;49:10–21.\nRodriguez-Pinilla SM, Rodriguez-Gil Y, Moreno-Bueno G, Sarrio D, Martin-Guijarro MC, Hernandez L, et al. Sporadic invasive breast carcinoma with medullary features display a basal-like phenotype: an immunohistochemical and gene amplification study. Am J Surg Pathol. 2007;31:501–8.\nMahler-Araujo B, Savage K, Parry S, Reis-Filho JS. Reduction of E-cadherin expression is associated with non-lobular breast carcinomas of basal-like and triple negative phenotype. J Clin Pathol. 2008;61:615–20.",{"EN":1378},"Expression profiling of invasive breast carcinomas by DNA microarray techniques has identified five distinct subtypes of tumors (luminal A, luminal B, normal breast-like, HER2 overexpression, and basal-like) that are associated with different clinical outcomes and with different chemotherapy. Basal-like carcinoma is associated with younger patient age, high histological grade, aggressive clinical course, development of distant metastasis, poor prognosis, and relatively high mortality rate. Basal-like carcinomas do not express estrogen receptor, progesterone receptor, or HER2 (triple-negative phenotype). Therefore, patients with basal-like carcinomas are not likely to benefit from endocrine therapies or trastuzumab, but are likely to benefit from systemic chemotherapy. Although genetic, morphological, and immunohistochemical features of basal-like carcinomas have been reported, there is no universal definition for those tumors. Furthermore, there are no specific morphological and immunohistochemical features that can identify those tumors in routine diagnostic materials. In the present paper, we present data of histological and cytological features of basal-like breast carcinoma, and discuss about its morphological spectrum.",{"EN":1380},"Morphological characteristics of basal-like subtype of breast carcinoma with special reference to cytopathological features",{"VOID":1382},"10.1007\u002Fs12282-009-0108-x","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs12282-009-0108-x",[1385,1400,1414,1429,1441],{"id":1386,"sortIndex":200,"researcher":22,"roles":1387,"affiliations":1388,"properties":1397},"958440d3-ce1a-4b19-b87a-76465089e89c",[259],[1389],{"id":22,"sortIndex":23,"affiliation":1390,"properties":22},{"id":1391,"createTime":1392,"updateTime":1392,"relativeEntities":1393,"slug":22,"properties":1394,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"a1178eb4-c939-4120-b2a5-80e6cfaee248","2024-01-08T17:39:12.688+00:00",[],{"title":1395},{"VI":1396},"Department of Pathology, Mie University, School of Medicine, Tsu, Japan",{"title":1398},{"VI":1399},"Misao Yoneda",{"id":1401,"sortIndex":376,"researcher":22,"roles":1402,"affiliations":1403,"properties":1412},"9724519b-51ab-4be5-bd9e-46f8832da06c",[259],[1404],{"id":22,"sortIndex":23,"affiliation":1405,"properties":22},{"id":1406,"createTime":1407,"updateTime":1407,"relativeEntities":1408,"slug":22,"properties":1409,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"68b2cf6a-8d27-426b-892b-009ecaa4b881","2024-01-01T09:00:22.125+00:00",[],{"title":1410},{"VI":1411},"Pathology Section, Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan",{"title":1413},{"VI":794},{"id":1415,"sortIndex":175,"researcher":22,"roles":1416,"affiliations":1417,"properties":1426},"556a3efa-0042-4472-baca-873364e90f02",[259],[1418],{"id":22,"sortIndex":23,"affiliation":1419,"properties":22},{"id":1420,"createTime":1421,"updateTime":1421,"relativeEntities":1422,"slug":22,"properties":1423,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"96f1e288-f17e-491c-9944-0cc9b0065e4d","2024-01-09T16:48:23.602+00:00",[],{"title":1424},{"VI":1425},"Department of Diagnostic Imaging, Mie University Hospital, Tsu, Japan",{"title":1427},{"VI":1428},"Kakuya Kitagawa",{"id":1430,"sortIndex":199,"researcher":22,"roles":1431,"affiliations":1432,"properties":1438},"a31deef7-4ea0-449f-bb29-b11076cc3c37",[259],[1433],{"id":22,"sortIndex":23,"affiliation":1434,"properties":22},{"id":1391,"createTime":1392,"updateTime":1392,"relativeEntities":1435,"slug":22,"properties":1436,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1437},{"VI":1396},{"title":1439},{"VI":1440},"Taizou Shiraishi",{"id":1442,"sortIndex":23,"researcher":22,"roles":1443,"affiliations":1444,"properties":1453},"e34cdfc0-490f-4e0a-9220-e8ed796ee476",[259],[1445],{"id":22,"sortIndex":23,"affiliation":1446,"properties":22},{"id":1447,"createTime":1448,"updateTime":1448,"relativeEntities":1449,"slug":22,"properties":1450,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"3017e00e-ccf2-4964-8537-83d40076ed5e","2024-01-09T16:48:23.571+00:00",[],{"title":1451},{"VI":1452},"Department of Clinical Pathology, Matsusaka Chuo General Hospital, Matsusaka, Japan",{"title":1454},{"VI":1455},"Akinori Ishihara",{"url":1383,"publisher":1457,"properties":1486},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1458,"slug":10,"properties":1459,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":1464,"manageAffiliations":1465,"indexDatabases":1466,"url":22,"thumbnailPath":22,"statistic":1481,"gsStatistic":22,"type":231,"analyzePriority":22},[],{"issn":1460,"eissn":1461,"title":1462,"url":1463},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},[],[],[1467,1474],{"id":84,"indexDatabase":1468,"url":97,"indexYears":98,"academicFieldIds":1473,"indexDatabaseRanking":104},{"id":86,"createTime":87,"updateTime":88,"relativeEntities":1469,"label":1470,"description":1471,"key":94,"publicationTags":1472,"standard":22},[],{"EN":91,"VI":91},{"EN":91,"VI":93},[96],[100,101,102,103],{"id":106,"indexDatabase":1475,"url":121,"indexYears":22,"academicFieldIds":1480,"indexDatabaseRanking":22},{"id":108,"createTime":109,"updateTime":110,"relativeEntities":1476,"label":1477,"description":1478,"key":117,"publicationTags":1479,"standard":22},[],{"EN":113,"VI":113},{"VI":115,"EN":116},[119,120],[123,124],{"impactFactor":23,"impactFactorByYear":1482,"i10Index":140,"i10IndexLast5Year":141,"totalPublication":142,"totalPublicationByYear":1483,"totalCitation":171,"totalCitationByYear":1484,"totalCitationPerPublication":201,"totalCitationPerPublicationByYear":1485,"hindexLast5Year":230,"hindex":230},{"2008":127,"2009":128,"2012":129,"2013":130,"2014":131,"2015":132,"2016":131,"2017":133,"2018":134,"2019":135,"2020":136,"2021":137,"2022":138,"2023":139},{"1994":144,"1995":145,"1996":146,"1997":147,"1998":148,"1999":149,"2000":149,"2001":147,"2002":150,"2003":151,"2004":150,"2005":152,"2006":153,"2007":154,"2008":155,"2009":156,"2010":157,"2011":153,"2012":158,"2013":159,"2014":160,"2015":161,"2016":162,"2017":163,"2018":164,"2019":165,"2020":166,"2021":167,"2022":168,"2023":169,"2024":170},{"1994":173,"1995":174,"1996":175,"1997":176,"1998":177,"1999":178,"2000":179,"2001":180,"2002":181,"2003":182,"2004":183,"2005":184,"2006":185,"2007":186,"2008":187,"2009":188,"2010":189,"2011":157,"2012":190,"2013":191,"2014":192,"2015":193,"2016":183,"2017":194,"2018":184,"2019":195,"2020":196,"2021":197,"2022":198,"2023":199,"2024":200},{"1994":203,"1995":204,"1996":205,"1997":206,"1998":207,"1999":130,"2000":208,"2001":209,"2002":210,"2003":201,"2004":211,"2005":212,"2006":213,"2007":214,"2008":215,"2009":216,"2010":217,"2011":218,"2012":219,"2013":175,"2014":220,"2015":221,"2016":222,"2017":223,"2018":224,"2019":225,"2020":226,"2021":227,"2022":228,"2023":229,"2024":205},{"volume":1487,"pages":1489},{"VOID":1488},"16",{"VOID":1490},"179-185","2009-05-23",2009,{"id":1494,"createTime":1495,"updateTime":1496,"relativeEntities":1497,"slug":1498,"properties":1499,"entityType":251,"verifyStatus":252,"verifyTime":1496,"verifyNote":253,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"primaryUrl":1508,"fullTextUrl":22,"authors":1509,"publicationType":525,"publisherRelationship":1639,"citationCount":22,"citationInfo":22,"publishDate":1674,"publishYear":1675,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":22,"openAccess":22,"references":22,"isForceReanalyzing":563},"de116b02-4ac2-4095-8f74-6b95f0cf9855","2024-01-11T06:17:46.599+00:00","2024-12-25T23:56:50.817+00:00",[],"Simultaneous-comparison-between-strain-and-shear-wave-elastography-of-breast-masses-for-the-differentiation-of-benign-and-malignant-lesions-by-qualitative-and-quantitative-assessments",{"references":1500,"abstract":1502,"title":1504,"doi":1506},{"VOID":1501},"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68:7–30.\nKornecki A. Current status of breast ultrasound. Can Assoc Radiol J. 2011;62:31–40.\nHooley RJ, Scoutt LM, Philpotts LE. Breast ultrasonography: state of the art. Radiology. 2013;268:642–59.\nD’Orsi CJ, Sickles EA, Mendelson EB, Morris EA. ACR BI-RADS atlas, breast imaging reporting and data system. Reston, VA: American College of Radiology; 2013.\nRao AA, Feneis J, Lalonde C, Ojeda-Fournier H. A pictorial review of changes in the BI-RADS fifth edition. Radiographics. 2016;36:623–39.\nChoi EJ, Lee EH, Kim YM, Chang YW, Lee JH, Park YM, et al. Interobserver agreement in breast ultrasound categorization in the mammography and ultrasonography study for breast cancer screening effectiveness (MUST-BE) trial: results of a preliminary study. Ultrasonography. 2018;38:172–80.\nShiina T, Nightingale KR, Palmeri ML, Hall TJ, Bamber JC, Barr RG, et al. WFUMB guidelines and recommendations for clinical use of ultrasound elastography, part 1: basic principles and terminology. Ultrasound Med Biol. 2015;41:1126–47.\nGarra BS, Cespedes EI, Ophir J, Spratt SR, Zuurbier RA, Magnant CM, et al. Elastography of breast lesions: initial clinical results. Radiology. 1997;202:79–86.\nItoh A, Ueno E, Tohno E, Kamma H, Takahashi H, Shiina T, et al. Breast disease: clinical application of US elastography for diagnosis. Radiology. 2006;239:341–50.\nSadigh G, Carlos RC, Neal CH. Dwamena BA. Ultrasonographic differentiation of malignant from benign breast lesions: a meta-analytic comparison of elasticity and BIRADS scoring. Breast Cancer Res Treat. 2012;133:23–35.\nAthanasiou A, Tardivon A, Tanter M, Sigal-Zafrani B, Bercoff J, Deffieux T, et al. Breast lesions: quantitative elastography with supersonic shear imaging–preliminary results. Radiology. 2010;256:297–303.\nXu H, Rao M, Varghese T, Sommer A, Baker S, Hall TJ, et al. Axial-shear strain imaging for differentiating benign and malignant breast masses. Ultrasound Med Biol. 2010;36:1813–24.\nBerg WA, Cosgrove DO, Doré CJ, Schäfer FK, Svensson WE, Hooley RJ, et al. Shear-wave elastography improves the specificity of breast US: the BE1 multinational study of 939 masses. Radiology. 2012;262:435–49.\nEvans A, Whelehan P, Thomson K, Brauer K, Jordan L, Purdie C, et al. Differentiating benign from malignant solid breast masses: value of shear wave elastography according to lesion stiffness combined with greyscale ultrasound according to BI-RADS classification. Br J Cancer. 2012;107:224–9.\nSong EJ, Sohn YM, Seo M. Diagnostic performances of shear-wave elastography and B-mode ultrasound to differentiate benign and malignant breast lesions: the emphasis on the cutoff value of qualitative and quantitative parameters. Clin Imaging. 2018;50:302–7.\nChang JM, Won JK, Lee KB, Park IA, Yi A, Moon WK. Comparison of shear-wave and strain ultrasound elastography in the differentiation of benign and malignant breast lesions. AJR Am J Roentgenol. 2013;201:347–56.\nYouk JH, Son EJ, Gweon HM, Kim H, Park YJ, Kim JA. Comparison of strain and shear wave elastography for the differentiation of benign from malignant breast lesions, combined with B-mode ultrasonography: qualitative and quantitative assessments. Ultrasound Med Biol. 2014;40:2336–44.\nSeo M, Ahn HS, Park SH, Lee JB, Choi BI, Sohn YM, et al. Comparison and combination of strain and shear wave elastography of breast masses for differentiation of benign and malignant lesions by quantitative assessment: preliminary study. J Ultrasound Med. 2018;37:99–109.\nKim HJ, Kim SM, Kim B, La Yun B, Jang M, Ko Y, et al. Comparison of strain and shear wave elastography for qualitative and quantitative assessment of breast masses in the same population. Sci Rep. 2018;8:6197.\nKanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2013;48:452–8.\nLevental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, et al. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell. 2009;25(139):891–906.\nDesmedt C, Haibe-Kains B, Wirapati P, Buyse M, Larsimont D, Bontempi G, et al. Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes. Clin Cancer Res. 2008;14:5158–65.\nFujioka T, Kubota K, Kikuchi Y, Tsuchiya J, Tateishi U, Kasaharak M, et al. The feasibility of using 18F-FDG-PET\u002FCT in patients with mucinous breast carcinoma. Nucl Med Commun. 2018;39:1033–8.\nFujioka T, Kubota K, Toriihara A, Machida Y, Okazawa K, Nakagawa T, et al. Tumor characteristics of ductal carcinoma in situ of breast visualized on [F-18] fluorodeoxyglucose-positron emission tomography\u002Fcomputed tomography: results from a retrospective study. World J Radiol. 2016;28(8):743–9.\nChang JM, Park IA, Lee SH, Kim WH, Bae MS, Koo HR, et al. Stiffness of tumours measured by shear-wave elastography correlated with subtypes of breast cancer. Eur Radiol. 2013;23:2450–8.\nYouk JH, Gweon HM, Son EJ, Kim JA, Jeong J. Shear-wave elastography of invasive breast cancer: correlation between quantitative mean elasticity value and immunohistochemical profile. Breast Cancer Res Treat. 2013;138:119–26.\nEvans A, Whelehan P, Thomson K, McLean D, Brauer K, Purdie C, et al. Invasive breast cancer: relationship between shear-wave elastographic findings and histologic prognostic factors. Radiology. 2012;263:673–7.",{"EN":1503},"To compare the addition of diagnostic strain elastography (SE) and shear wave elastography (SWE) values to the conventional B-mode ultrasonography in differentiating between benign and malignant breast masses by qualitative and quantitative assessments. B-mode ultrasound, SE, and SWE were simultaneously performed using one ultrasound system in 148 breast masses; 88 of them were malignant. The breast imaging reporting and data system category in the B-mode, Tsukuba score (SETsu), Fat-Lesion-Ratio (SEFLR) in SE, and five-point color assessment (SWEcol) and elasticity values (SWEela) in SWE were assessed. The results were compared using the area under the receiver-operating characteristic curve (AUC). The AUC for B-mode and each elastography were similar (B-mode, 0.889; SETsu, 0.885; SEFLR, 0.875; SWEcol, 0.881; SWEela, 0.885; P > 0.05). The combined sets between B-mode and either of the elastography technique showed good diagnostic performance (B-mode + SETsu, 0.903; B-mode + SEFLR, 0.909; B-mode + SWEcol, 0.919; B-mode + SWEela, 0.914). B-mode + SWEcol and B-mode + SWEela showed a higher AUC than B-mode alone (P = 0.026 and 0.029), and B-mode + SETsu and B-mode + SEFLR showed comparable AUC to B-mode alone (P = 0.196 and 0.085). There was no significant difference between qualitative and quantitative assessments for the combined sets of B-mode and elastography (P > 0.05). The addition of both SE and SWE to B-mode ultrasound improved the diagnostic performance with increased AUC, and especially SWE was more useful than SE, and no significant difference was found between qualitative and quantitative assessments.",{"EN":1505},"Simultaneous comparison between strain and shear wave elastography of breast masses for the differentiation of benign and malignant lesions by qualitative and quantitative assessments",{"VOID":1507},"10.1007\u002Fs12282-019-00985-0","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs12282-019-00985-0",[1510,1527,1539,1555,1567,1579,1591,1603,1615,1627],{"id":1511,"sortIndex":80,"researcher":22,"roles":1512,"affiliations":1513,"properties":1524},"a5250aef-f8bd-4985-894d-9e586b8c4b4b",[259],[1514],{"id":22,"sortIndex":23,"affiliation":1515,"properties":22},{"id":1516,"createTime":1517,"updateTime":1518,"relativeEntities":1519,"slug":1520,"properties":1521,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"006adc8c-17c1-48d2-9e56-c1bf2cb9bbc2","2024-01-13T03:49:51.753+00:00","2025-06-11T13:55:06.128+00:00",[],"Department-of-Surgery-Breast-Surgery-Tokyo-Medical-and-Dental-University-Tokyo-Japan",{"title":1522},{"VI":1523},"Department of Surgery, Breast Surgery, Tokyo Medical and Dental University, Tokyo, Japan",{"title":1525},{"VI":1526},"Toshiyuki Ishiba",{"id":1528,"sortIndex":274,"researcher":22,"roles":1529,"affiliations":1530,"properties":1536},"2015cb70-3acb-4441-9f40-3ebcaa64d0a6",[259],[1531],{"id":22,"sortIndex":23,"affiliation":1532,"properties":22},{"id":1516,"createTime":1517,"updateTime":1518,"relativeEntities":1533,"slug":1520,"properties":1534,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1535},{"VI":1523},{"title":1537},{"VI":1538},"Tsuyoshi Nakagawa",{"id":1540,"sortIndex":199,"researcher":22,"roles":1541,"affiliations":1542,"properties":1552},"573bb62f-a3af-45dd-8c4f-d26f15f353f6",[259],[1543],{"id":22,"sortIndex":23,"affiliation":1544,"properties":22},{"id":1545,"createTime":1546,"updateTime":1546,"relativeEntities":1547,"slug":1548,"properties":1549,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"a347308d-8bfb-4f98-88ad-a61c9341b25a","2024-04-21T05:19:51.570+00:00",[],"Department-of-Radiology-Tokyo-Medical-and-Dental-University-Tokyo-Japan",{"title":1550},{"EN":1551},"Department of Radiology, Tokyo Medical and Dental University, Tokyo, Japan",{"title":1553},{"VI":1554},"Leona Katsuta",{"id":1556,"sortIndex":200,"researcher":22,"roles":1557,"affiliations":1558,"properties":1564},"8e316b0d-dd99-4c77-9b8f-09d925105194",[259],[1559],{"id":22,"sortIndex":23,"affiliation":1560,"properties":22},{"id":1545,"createTime":1546,"updateTime":1546,"relativeEntities":1561,"slug":1548,"properties":1562,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1563},{"EN":1551},{"title":1565},{"VI":1566},"Yuka Kikuchi",{"id":1568,"sortIndex":68,"researcher":22,"roles":1569,"affiliations":1570,"properties":1576},"500bcf10-c54e-49fe-9261-6fb366390d62",[259],[1571],{"id":22,"sortIndex":23,"affiliation":1572,"properties":22},{"id":1516,"createTime":1517,"updateTime":1518,"relativeEntities":1573,"slug":1520,"properties":1574,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1575},{"VI":1523},{"title":1577},{"VI":1578},"Goshi Oda",{"id":1580,"sortIndex":175,"researcher":22,"roles":1581,"affiliations":1582,"properties":1588},"041b5a2e-2282-4e63-9b77-a42f41d2e35c",[259],[1583],{"id":22,"sortIndex":23,"affiliation":1584,"properties":22},{"id":1545,"createTime":1546,"updateTime":1546,"relativeEntities":1585,"slug":1548,"properties":1586,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1587},{"EN":1551},{"title":1589},{"VI":1590},"Kazunori Kubota",{"id":1592,"sortIndex":376,"researcher":22,"roles":1593,"affiliations":1594,"properties":1600},"1b93742e-e586-48fe-8435-5142b1fa5f3e",[259],[1595],{"id":22,"sortIndex":23,"affiliation":1596,"properties":22},{"id":1545,"createTime":1546,"updateTime":1546,"relativeEntities":1597,"slug":1548,"properties":1598,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1599},{"EN":1551},{"title":1601},{"VI":1602},"Mio Mori",{"id":1604,"sortIndex":23,"researcher":22,"roles":1605,"affiliations":1606,"properties":1612},"0b47a39e-6c17-4985-b334-beb8e12c39b8",[259],[1607],{"id":22,"sortIndex":23,"affiliation":1608,"properties":22},{"id":1545,"createTime":1546,"updateTime":1546,"relativeEntities":1609,"slug":1548,"properties":1610,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1611},{"EN":1551},{"title":1613},{"VI":1614},"Tomoyuki Fujioka",{"id":1616,"sortIndex":178,"researcher":22,"roles":1617,"affiliations":1618,"properties":1624},"fe16e848-ea9d-4a3e-ad5b-ac4f9d8cf359",[259],[1619],{"id":22,"sortIndex":23,"affiliation":1620,"properties":22},{"id":1545,"createTime":1546,"updateTime":1546,"relativeEntities":1621,"slug":1548,"properties":1622,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1623},{"EN":1551},{"title":1625},{"VI":1626},"Ukihide Tateishi",{"id":1628,"sortIndex":292,"researcher":22,"roles":1629,"affiliations":1630,"properties":1636},"50ac7076-cc72-43ca-9be2-00c78122aadc",[259],[1631],{"id":22,"sortIndex":23,"affiliation":1632,"properties":22},{"id":1516,"createTime":1517,"updateTime":1518,"relativeEntities":1633,"slug":1520,"properties":1634,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1635},{"VI":1523},{"title":1637},{"VI":1638},"Mai Kasahara",{"url":1508,"publisher":1640,"properties":1669},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1641,"slug":10,"properties":1642,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":1647,"manageAffiliations":1648,"indexDatabases":1649,"url":22,"thumbnailPath":22,"statistic":1664,"gsStatistic":22,"type":231,"analyzePriority":22},[],{"issn":1643,"eissn":1644,"title":1645,"url":1646},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},[],[],[1650,1657],{"id":84,"indexDatabase":1651,"url":97,"indexYears":98,"academicFieldIds":1656,"indexDatabaseRanking":104},{"id":86,"createTime":87,"updateTime":88,"relativeEntities":1652,"label":1653,"description":1654,"key":94,"publicationTags":1655,"standard":22},[],{"EN":91,"VI":91},{"EN":91,"VI":93},[96],[100,101,102,103],{"id":106,"indexDatabase":1658,"url":121,"indexYears":22,"academicFieldIds":1663,"indexDatabaseRanking":22},{"id":108,"createTime":109,"updateTime":110,"relativeEntities":1659,"label":1660,"description":1661,"key":117,"publicationTags":1662,"standard":22},[],{"EN":113,"VI":113},{"VI":115,"EN":116},[119,120],[123,124],{"impactFactor":23,"impactFactorByYear":1665,"i10Index":140,"i10IndexLast5Year":141,"totalPublication":142,"totalPublicationByYear":1666,"totalCitation":171,"totalCitationByYear":1667,"totalCitationPerPublication":201,"totalCitationPerPublicationByYear":1668,"hindexLast5Year":230,"hindex":230},{"2008":127,"2009":128,"2012":129,"2013":130,"2014":131,"2015":132,"2016":131,"2017":133,"2018":134,"2019":135,"2020":136,"2021":137,"2022":138,"2023":139},{"1994":144,"1995":145,"1996":146,"1997":147,"1998":148,"1999":149,"2000":149,"2001":147,"2002":150,"2003":151,"2004":150,"2005":152,"2006":153,"2007":154,"2008":155,"2009":156,"2010":157,"2011":153,"2012":158,"2013":159,"2014":160,"2015":161,"2016":162,"2017":163,"2018":164,"2019":165,"2020":166,"2021":167,"2022":168,"2023":169,"2024":170},{"1994":173,"1995":174,"1996":175,"1997":176,"1998":177,"1999":178,"2000":179,"2001":180,"2002":181,"2003":182,"2004":183,"2005":184,"2006":185,"2007":186,"2008":187,"2009":188,"2010":189,"2011":157,"2012":190,"2013":191,"2014":192,"2015":193,"2016":183,"2017":194,"2018":184,"2019":195,"2020":196,"2021":197,"2022":198,"2023":199,"2024":200},{"1994":203,"1995":204,"1996":205,"1997":206,"1998":207,"1999":130,"2000":208,"2001":209,"2002":210,"2003":201,"2004":211,"2005":212,"2006":213,"2007":214,"2008":215,"2009":216,"2010":217,"2011":218,"2012":219,"2013":175,"2014":220,"2015":221,"2016":222,"2017":223,"2018":224,"2019":225,"2020":226,"2021":227,"2022":228,"2023":229,"2024":205},{"volume":1670,"pages":1672},{"VOID":1671},"26",{"VOID":1673},"792-798","2019-06-07",2019,{"id":1677,"createTime":1678,"updateTime":1679,"relativeEntities":1680,"slug":1681,"properties":1682,"entityType":251,"verifyStatus":252,"verifyTime":1691,"verifyNote":253,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"primaryUrl":1692,"fullTextUrl":22,"authors":1693,"publicationType":525,"publisherRelationship":1802,"citationCount":22,"citationInfo":22,"publishDate":1837,"publishYear":1367,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":22,"openAccess":22,"references":22,"isForceReanalyzing":563},"d6fbe310-ef0a-412a-a195-cc18994d0041","2024-02-18T18:42:48.003+00:00","2025-01-24T23:55:21.767+00:00",[],"Apogossypolone-induces-autophagy-and-apoptosis-in-breast-cancer-MCF-7-cells-in-vitro-and-in-vivo",{"references":1683,"abstract":1685,"title":1687,"doi":1689},{"VOID":1684},"Alsabeh R, Wilson CS, Ahn CW. Expression of bcl-2 by breast cancer: a possible diagnostic application. Mod Pathol. 1996;9:439–44.\nAggarwal H, Lubana PS, Jain DK. Estimation of BCL-2 protein in carcinoma of the breast and its clinical correlation in locally advanced breast cancer. J Cancer Res Ther. 2007;3:207–10.\nPoelman SM, Adeyanju MO, Robertson MA, Recant WM, Karrison T, Fleming GF, et al. Human breast cancer susceptibility to paclitaxel therapy is independent of Bcl-2 expression. Clin Cancer Res. 2000;6:4043–8.\nJaroszewski JW, Kaplan O, Cohen JS. Action of gossypol and rhodamine 123 on wild type and multidrug-resistant MCF-7 human breast cancer cells: 31P nuclear magnetic resonance and toxicity studies. Cancer Res. 1990;50:6936–43.\nMarzo I, Naval J. Bcl-2 family members as molecular targets in cancer therapy. Biochem Pharmacol. 2008;76:939–46.\nKang MH, Reynolds CP. Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res. 2009;15:1126–32.\nZhan Y, Jia G, Wu D, Xu Y, Xu L. Design and synthesis of a gossypol derivative with improved antitumor activities. Arch Pharm (Weinheim). 2009;342:223–9.\nGilbert NE, O’Reilly JE, Chang CJ, Lin YC, Brueggemeier RW. Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. Life Sci. 1995;57:61–7.\nCoyle T, Levante S, Shetler M, Winfield J. In vitro and in vivo cytotoxicity of gossypol against central nervous system tumor cell lines. J Neurooncol. 1994;19:25–35.\nKitada S, Kress CL, Krajewska M, Jia L, Pellecchia M, Reed JC. Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). Blood. 2008;111:3211–9.\nWei J, Kitada S, Rega MF, Emdadi A, Yuan H, Cellitti J, et al. Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins. Mol Cancer Ther. 2009;8:904–13.\nLiu XH, Zheng XF, Wang YL. Inhibitive effect of 3-bromopyruvic acid on human breast cancer MCF-7 cells involves cell-cycle arrest and apoptotic induction. Chin Med J (Engl). 2009;122:1681–5.\nBursch W, Ellinger A, Kienzl H, Torok L, Pandey S, et al. Active cell death induced by the anti-estrogens tamoxifen and ICI 164,384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy. Carcinogenesis. 1996;17:1595–607.\nPegoraro L, Palumbo A, Erikson J, Falda M, Giovanazzo B, Emanuel BS, et al. A 14;18 and an 8;14 chromosome translocation in a cell line derived from an acute B-cell leukemia. Proc Natl Acad Sci USA. 1984;81:7166–70.\nRosse T, Olivier R, Monney L, Rager M, Conus S, Fellay I, et al. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature. 1998;391:496–9.\nKirkin V, Joos S, Zornig M. The role of Bcl-2 family members in tumorigenesis. Biochim Biophys Acta. 2004;1644:229–49.\nArisan ED, Kutuk O, Tezil T, Bodur C, Telci D, Basaga H. Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells. Breast Cancer Res Treat. 2010;119:271–81.\nPattingre S, Levine B. Bcl-2 inhibition of autophagy: a new route to cancer? Cancer Res. 2006;66:2885–8.\nKanematsu S, Uehara N, Miki H, Yoshizawa K, Kawanaka A, Yuri T, et al. Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells. Anticancer Res. 2010;30:3381–90.\nKo CH, Shen SC, Yang LY, Lin CW, Chen YC. Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells. Int J Cancer. 2007;121:1670–9.\nYe W, Chang HL, Wang LS, Huang YW, Shu S, Sugimoto Y, et al. Induction of apoptosis by (−)-gossypol-enriched cottonseed oil in human breast cancer cells. Int J Mol Med. 2010;26:113–9.\nBaehrecke EH. Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol. 2005;6:505–10.\nPattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 2005;122:927–39.\nAkar U, Chaves-Reyez A, Barria M, Tari A, Sanguino A, Kondo Y, et al. Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells. Autophagy. 2008;4:669–79.\nZhang XQ, Huang XF, Hu XB, Zhan YH, An QX, Yang SM, et al. Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro. Asian J Androl. 2010;12:697–708.\nLian J, Karnak D, Xu L. The Bcl-2-Beclin 1 interaction in (−)-gossypol-induced autophagy versus apoptosis in prostate cancer cells. Autophagy. 2010;6:1201–3.",{"EN":1686},"Apogossypolone (ApoG2), a new derivative of gossypol, is a potent cell-growth inhibitor. ApoG2 has been demonstrated to have superior anti-tumor activity than gossypol in Bcl-2 transgenic mice. The purpose of this study was to investigate the inhibitory effect of ApoG2 on breast cancer cell line MCF-7 in vitro and in vivo, and to investigate its anti-tumor mechanism. MCF-7 cell line in culture was treated with ApoG2. The inhibitory effects of ApoG2 on cell growth were measured by MTT and colony-formation assay. The cell apoptotic rate and cell cycle were analyzed by use of flow cytometry (FCM). The ultrastructural changes were observed by transmission electron microscopy. Autophagy was detected by acridine orange staining. Expression of Bcl-2, Bax, and Beclin 1 proteins was measured by western blot analysis. The inhibitory effect of ApoG2 on MCF-7 cell proliferation was dose and time-dependent. The maximum effect was observed when cells were incubated for 72 h with 40 μM ApoG2. ApoG2 at 5 μM also inhibited colony formation. FCM assay indicated that ApoG2 induced cell apoptosis and caused cell arrest in the S phase and G2\u002FM phase. Transmission electron microscopic examination and acridine orange staining showed that ApoG2 induced intracellular autolysosome formation. Furthermore, ApoG2 reduced Bcl-2 expression, and enhanced expression of Bax and Beclin 1. Xenografting of MCF-7 cells in mice can also be inhibited by ApoG2. ApoG2, a novel anti-apoptotic Bcl-2 agent, inhibits proliferation of breast cancer cell line MCF-7 by inducing cell apoptosis and autophagy.",{"EN":1688},"Apogossypolone induces autophagy and apoptosis in breast cancer MCF-7 cells in vitro and in vivo",{"VOID":1690},"10.1007\u002Fs12282-012-0372-z","2025-01-24T23:55:21.766+00:00","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs12282-012-0372-z",[1694,1709,1721,1733,1748,1763,1775,1787],{"id":1695,"sortIndex":200,"researcher":22,"roles":1696,"affiliations":1697,"properties":1706},"ea5091cf-b535-4f4f-a757-9edc43800245",[259],[1698],{"id":22,"sortIndex":23,"affiliation":1699,"properties":22},{"id":1700,"createTime":1701,"updateTime":1701,"relativeEntities":1702,"slug":22,"properties":1703,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"2388f37a-e217-4dbc-b8ee-a0d1e56eb387","2024-02-18T18:42:48.095+00:00",[],{"title":1704},{"VI":1705},"Department of Oncology, The Second Affiliated Hospital, Southern Medical University, Zhujiang Hospital, Guangzhou, People’s Republic of China",{"title":1707},{"VI":1708},"Jie Huang",{"id":1710,"sortIndex":175,"researcher":22,"roles":1711,"affiliations":1712,"properties":1718},"7d03d874-0e69-4c23-8df9-e4dcfe42f9e6",[259],[1713],{"id":22,"sortIndex":23,"affiliation":1714,"properties":22},{"id":1700,"createTime":1701,"updateTime":1701,"relativeEntities":1715,"slug":22,"properties":1716,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1717},{"VI":1705},{"title":1719},{"VI":1720},"Fang Wei",{"id":1722,"sortIndex":23,"researcher":22,"roles":1723,"affiliations":1724,"properties":1730},"1d753ac8-aeeb-46b6-9f57-20ebddbbb9d8",[259],[1725],{"id":22,"sortIndex":23,"affiliation":1726,"properties":22},{"id":1700,"createTime":1701,"updateTime":1701,"relativeEntities":1727,"slug":22,"properties":1728,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1729},{"VI":1705},{"title":1731},{"VI":1732},"Xiaoge Niu",{"id":1734,"sortIndex":292,"researcher":22,"roles":1735,"affiliations":1736,"properties":1745},"607c2c50-c411-450c-8349-da8b8b1a54ec",[259],[1737],{"id":22,"sortIndex":23,"affiliation":1738,"properties":22},{"id":1739,"createTime":1740,"updateTime":1740,"relativeEntities":1741,"slug":22,"properties":1742,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"9748a075-6514-4d7f-bd89-c5324311d02b","2024-02-18T18:42:48.115+00:00",[],{"title":1743},{"VI":1744},"Departments of Urology and Radiation Oncology, University of Kansas Cancer Center, University of Kansas Medical School, Kansas, USA",{"title":1746},{"VI":1747},"Liang Xu",{"id":1749,"sortIndex":376,"researcher":22,"roles":1750,"affiliations":1751,"properties":1760},"3056b637-6766-4075-bb85-b4e5855416a8",[259],[1752],{"id":22,"sortIndex":23,"affiliation":1753,"properties":22},{"id":1754,"createTime":1755,"updateTime":1755,"relativeEntities":1756,"slug":22,"properties":1757,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"83c52fff-fd39-483c-8d7f-f18357199fd9","2024-02-18T18:42:48.044+00:00",[],{"title":1758},{"VI":1759},"Department of Thoracic Surgery, The Second Affiliated Hospital, Southern Medical University, Zhujiang Hospital, Guangzhou, People’s Republic of China",{"title":1761},{"VI":1762},"Shaobin Li",{"id":1764,"sortIndex":80,"researcher":22,"roles":1765,"affiliations":1766,"properties":1772},"84bd07f5-eaaf-4fa3-9452-d94bd669c43c",[259],[1767],{"id":22,"sortIndex":23,"affiliation":1768,"properties":22},{"id":1700,"createTime":1701,"updateTime":1701,"relativeEntities":1769,"slug":22,"properties":1770,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1771},{"VI":1705},{"title":1773},{"VI":1774},"Senming Wang",{"id":1776,"sortIndex":199,"researcher":22,"roles":1777,"affiliations":1778,"properties":1784},"e55d04d6-7482-4989-8b68-ae8f33cd3693",[259],[1779],{"id":22,"sortIndex":23,"affiliation":1780,"properties":22},{"id":1700,"createTime":1701,"updateTime":1701,"relativeEntities":1781,"slug":22,"properties":1782,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1783},{"VI":1705},{"title":1785},{"VI":1786},"Gang Wu",{"id":1788,"sortIndex":68,"researcher":22,"roles":1789,"affiliations":1790,"properties":1799},"264a65ea-9f50-4863-83a8-d61b2b91934b",[259],[1791],{"id":22,"sortIndex":23,"affiliation":1792,"properties":22},{"id":1793,"createTime":1794,"updateTime":1794,"relativeEntities":1795,"slug":22,"properties":1796,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"e51836c4-54b3-4516-9a0e-099f3fdeadb0","2024-01-22T00:37:44.843+00:00",[],{"title":1797},{"VI":1798},"CBLPath, Rye Brook, USA",{"title":1800},{"VI":1801},"Dongsheng Xu",{"url":1692,"publisher":1803,"properties":1832},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1804,"slug":10,"properties":1805,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":1810,"manageAffiliations":1811,"indexDatabases":1812,"url":22,"thumbnailPath":22,"statistic":1827,"gsStatistic":22,"type":231,"analyzePriority":22},[],{"issn":1806,"eissn":1807,"title":1808,"url":1809},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},[],[],[1813,1820],{"id":84,"indexDatabase":1814,"url":97,"indexYears":98,"academicFieldIds":1819,"indexDatabaseRanking":104},{"id":86,"createTime":87,"updateTime":88,"relativeEntities":1815,"label":1816,"description":1817,"key":94,"publicationTags":1818,"standard":22},[],{"EN":91,"VI":91},{"EN":91,"VI":93},[96],[100,101,102,103],{"id":106,"indexDatabase":1821,"url":121,"indexYears":22,"academicFieldIds":1826,"indexDatabaseRanking":22},{"id":108,"createTime":109,"updateTime":110,"relativeEntities":1822,"label":1823,"description":1824,"key":117,"publicationTags":1825,"standard":22},[],{"EN":113,"VI":113},{"VI":115,"EN":116},[119,120],[123,124],{"impactFactor":23,"impactFactorByYear":1828,"i10Index":140,"i10IndexLast5Year":141,"totalPublication":142,"totalPublicationByYear":1829,"totalCitation":171,"totalCitationByYear":1830,"totalCitationPerPublication":201,"totalCitationPerPublicationByYear":1831,"hindexLast5Year":230,"hindex":230},{"2008":127,"2009":128,"2012":129,"2013":130,"2014":131,"2015":132,"2016":131,"2017":133,"2018":134,"2019":135,"2020":136,"2021":137,"2022":138,"2023":139},{"1994":144,"1995":145,"1996":146,"1997":147,"1998":148,"1999":149,"2000":149,"2001":147,"2002":150,"2003":151,"2004":150,"2005":152,"2006":153,"2007":154,"2008":155,"2009":156,"2010":157,"2011":153,"2012":158,"2013":159,"2014":160,"2015":161,"2016":162,"2017":163,"2018":164,"2019":165,"2020":166,"2021":167,"2022":168,"2023":169,"2024":170},{"1994":173,"1995":174,"1996":175,"1997":176,"1998":177,"1999":178,"2000":179,"2001":180,"2002":181,"2003":182,"2004":183,"2005":184,"2006":185,"2007":186,"2008":187,"2009":188,"2010":189,"2011":157,"2012":190,"2013":191,"2014":192,"2015":193,"2016":183,"2017":194,"2018":184,"2019":195,"2020":196,"2021":197,"2022":198,"2023":199,"2024":200},{"1994":203,"1995":204,"1996":205,"1997":206,"1998":207,"1999":130,"2000":208,"2001":209,"2002":210,"2003":201,"2004":211,"2005":212,"2006":213,"2007":214,"2008":215,"2009":216,"2010":217,"2011":218,"2012":219,"2013":175,"2014":220,"2015":221,"2016":222,"2017":223,"2018":224,"2019":225,"2020":226,"2021":227,"2022":228,"2023":229,"2024":205},{"volume":1833,"pages":1835},{"VOID":1834},"21",{"VOID":1836},"223-230","2012-06-19",{"id":1839,"createTime":1840,"updateTime":1841,"relativeEntities":1842,"slug":1843,"properties":1844,"entityType":251,"verifyStatus":252,"verifyTime":1841,"verifyNote":253,"syncStatus":21,"languages":1857,"translateLanguages":22,"viewCount":23,"primaryUrl":1858,"fullTextUrl":22,"authors":1859,"publicationType":525,"publisherRelationship":1966,"citationCount":80,"citationInfo":2002,"publishDate":2004,"publishYear":1492,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":22,"openAccess":22,"references":2005,"isForceReanalyzing":563},"13364029-6d0e-4303-8207-6e6a600c8bfc","2024-04-16T08:12:55.434+00:00","2024-09-27T23:54:16.090+00:00",[],"Pathological-lymph-node-involvement-at-surgery-is-a-significant-predictive-factor-of-recurrence-in-locally-advanced-breast-cancer-treated-with-concomitant-epirubicin-docetaxel-neoadjuvant-chemotherapy-a-cohort-study",{"mag":1845,"keywords":1847,"openalex":1848,"abstract":1850,"title":1851,"pm":1853,"doi":1855},{"VOID":1846},"2020513659",{},{"VOID":1849},"W2020513659",{},{"EN":1852},"Pathological lymph node involvement at surgery is a significant predictive factor of recurrence in locally advanced breast cancer treated with concomitant epirubicin–docetaxel neoadjuvant chemotherapy: a cohort study",{"VOID":1854},"18504642",{"VOID":1856},"10.1007\u002Fs12282-008-0055-y",[582],"http:\u002F\u002Flink.springer.com\u002F10.1007\u002Fs12282-008-0055-y",[1860,1879,1898,1913,1932,1949],{"id":1861,"sortIndex":292,"researcher":22,"roles":1862,"affiliations":1863,"properties":1874},"c78bf7c5-3095-4af9-be7d-605c553ca6a0",[],[1864],{"id":1865,"sortIndex":23,"affiliation":1866,"properties":22},"f58d9634-b847-4828-a15d-5b1581d771f9",{"id":1867,"createTime":1868,"updateTime":1868,"relativeEntities":1869,"slug":1870,"properties":1871,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"30c226eb-7b87-46af-a26e-3eeceed5dedb","2024-04-16T08:12:55.473+00:00",[],"Breast-and-Endocrine-Surgery-Kumamoto-City-Hospital-1-1-60-Koto-Kumamoto-862-8505-Japan",{"title":1872},{"EN":1873},"Breast and Endocrine Surgery, Kumamoto City Hospital, 1-1-60 Koto, Kumamoto, 862-8505, Japan",{"openalex":1875,"title":1877},{"VOID":1876},"A5024576654",{"EN":1878},"Reiki Nishimura",{"id":1880,"sortIndex":199,"researcher":22,"roles":1881,"affiliations":1882,"properties":1893},"9f93a941-f6c1-4037-ab34-91504109dc80",[],[1883],{"id":1884,"sortIndex":23,"affiliation":1885,"properties":22},"a422705c-b517-4f4f-9970-5bd8788ca876",{"id":1886,"createTime":1887,"updateTime":1887,"relativeEntities":1888,"slug":1889,"properties":1890,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"2e8ae0b3-cc32-4ad9-b780-670d4fe72db9","2024-04-16T08:12:55.466+00:00",[],"Breast-and-Endocrine-Surgery-Faculty-of-Medical-and-Pharmaceutical-Science-Kumamoto-University-1-1-1-Honjo-Kumamoto-860-8556-Japan",{"title":1891},{"EN":1892},"Breast and Endocrine Surgery, Faculty of Medical and Pharmaceutical Science, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan",{"openalex":1894,"title":1896},{"VOID":1895},"A5035071748",{"EN":1897},"Hirotaka Iwase",{"id":1899,"sortIndex":23,"researcher":22,"roles":1900,"affiliations":1901,"properties":1908},"e0790b89-dbcb-43b2-9143-422816918e6a",[],[1902],{"id":1903,"sortIndex":23,"affiliation":1904,"properties":22},"c93c3600-4702-4d8b-ad44-0804b04de3b6",{"id":1886,"createTime":1887,"updateTime":1887,"relativeEntities":1905,"slug":1889,"properties":1906,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1907},{"EN":1892},{"openalex":1909,"title":1911},{"VOID":1910},"A5073695473",{"EN":1912},"Kazuharu Kai",{"id":1914,"sortIndex":175,"researcher":22,"roles":1915,"affiliations":1916,"properties":1927},"00783e47-8905-48a3-8730-b669d2aa4e9a",[],[1917],{"id":1918,"sortIndex":23,"affiliation":1919,"properties":22},"facc7c31-52d1-4e8d-863a-293306198f23",{"id":1920,"createTime":1921,"updateTime":1921,"relativeEntities":1922,"slug":1923,"properties":1924,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"b46a9a05-671c-4307-bd5b-a1b47b92ea33","2024-04-16T08:12:55.446+00:00",[],"Clinical-Pathology-Kumamoto-City-Hospital-1-1-60-Koto-Kumamoto-862-8505-Japan",{"title":1925},{"EN":1926},"Clinical Pathology, Kumamoto City Hospital, 1-1-60 Koto, Kumamoto, 862-8505, Japan",{"openalex":1928,"title":1930},{"VOID":1929},"A5088355556",{"EN":1931},"Haruhiko Miyayama",{"id":1933,"sortIndex":376,"researcher":22,"roles":1934,"affiliations":1935,"properties":1942},"13971c02-0fb3-4a6d-a33a-f760ad97a5cb",[],[1936],{"id":1937,"sortIndex":23,"affiliation":1938,"properties":22},"d48f1c5d-f8a9-4d92-9a15-0fa8fec85463",{"id":1920,"createTime":1921,"updateTime":1921,"relativeEntities":1939,"slug":1923,"properties":1940,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1941},{"EN":1926},{"openalex":1943,"orcid":1945,"title":1947},{"VOID":1944},"A5068419055",{"VOID":1946},"https:\u002F\u002Forcid.org\u002F0000-0002-0084-5500",{"EN":1948},"Nobuyuki Arima",{"id":1950,"sortIndex":200,"researcher":22,"roles":1951,"affiliations":1952,"properties":1959},"709eb09c-018c-41ce-9f41-ded82edeea75",[],[1953],{"id":1954,"sortIndex":23,"affiliation":1955,"properties":22},"08f0b23f-5cc2-447b-8056-58986132e6b8",{"id":1886,"createTime":1887,"updateTime":1887,"relativeEntities":1956,"slug":1889,"properties":1957,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":1958},{"EN":1892},{"openalex":1960,"orcid":1962,"title":1964},{"VOID":1961},"A5024725726",{"VOID":1963},"https:\u002F\u002Forcid.org\u002F0000-0001-6147-6828",{"EN":1965},"Yutaka Yamamoto",{"url":22,"publisher":1967,"properties":1996},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1968,"slug":10,"properties":1969,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":1974,"manageAffiliations":1975,"indexDatabases":1976,"url":22,"thumbnailPath":22,"statistic":1991,"gsStatistic":22,"type":231,"analyzePriority":22},[],{"issn":1970,"eissn":1971,"title":1972,"url":1973},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},[],[],[1977,1984],{"id":84,"indexDatabase":1978,"url":97,"indexYears":98,"academicFieldIds":1983,"indexDatabaseRanking":104},{"id":86,"createTime":87,"updateTime":88,"relativeEntities":1979,"label":1980,"description":1981,"key":94,"publicationTags":1982,"standard":22},[],{"EN":91,"VI":91},{"EN":91,"VI":93},[96],[100,101,102,103],{"id":106,"indexDatabase":1985,"url":121,"indexYears":22,"academicFieldIds":1990,"indexDatabaseRanking":22},{"id":108,"createTime":109,"updateTime":110,"relativeEntities":1986,"label":1987,"description":1988,"key":117,"publicationTags":1989,"standard":22},[],{"EN":113,"VI":113},{"VI":115,"EN":116},[119,120],[123,124],{"impactFactor":23,"impactFactorByYear":1992,"i10Index":140,"i10IndexLast5Year":141,"totalPublication":142,"totalPublicationByYear":1993,"totalCitation":171,"totalCitationByYear":1994,"totalCitationPerPublication":201,"totalCitationPerPublicationByYear":1995,"hindexLast5Year":230,"hindex":230},{"2008":127,"2009":128,"2012":129,"2013":130,"2014":131,"2015":132,"2016":131,"2017":133,"2018":134,"2019":135,"2020":136,"2021":137,"2022":138,"2023":139},{"1994":144,"1995":145,"1996":146,"1997":147,"1998":148,"1999":149,"2000":149,"2001":147,"2002":150,"2003":151,"2004":150,"2005":152,"2006":153,"2007":154,"2008":155,"2009":156,"2010":157,"2011":153,"2012":158,"2013":159,"2014":160,"2015":161,"2016":162,"2017":163,"2018":164,"2019":165,"2020":166,"2021":167,"2022":168,"2023":169,"2024":170},{"1994":173,"1995":174,"1996":175,"1997":176,"1998":177,"1999":178,"2000":179,"2001":180,"2002":181,"2003":182,"2004":183,"2005":184,"2006":185,"2007":186,"2008":187,"2009":188,"2010":189,"2011":157,"2012":190,"2013":191,"2014":192,"2015":193,"2016":183,"2017":194,"2018":184,"2019":195,"2020":196,"2021":197,"2022":198,"2023":199,"2024":200},{"1994":203,"1995":204,"1996":205,"1997":206,"1998":207,"1999":130,"2000":208,"2001":209,"2002":210,"2003":201,"2004":211,"2005":212,"2006":213,"2007":214,"2008":215,"2009":216,"2010":217,"2011":218,"2012":219,"2013":175,"2014":220,"2015":221,"2016":222,"2017":223,"2018":224,"2019":225,"2020":226,"2021":227,"2022":228,"2023":229,"2024":205},{"volume":1997,"pages":1998,"issue":2000},{"VOID":1488},{"VOID":1999},"42-48",{"VOID":2001},"1",{"total":80,"publishYear":22,"statisticByYear":2003},{"2014":175},"2009-01-01",[2006,2010,2014,2017,2021,2025,2029,2033,2036,2039,2043,2047,2050,2054,2058,2062,2066,2070,2074,2078,2082,2086],{"id":22,"text":2007,"url":22,"identifiers":2008},"Fisher B, Bryant J, Wolmark N, Mamounas E, Brown A, Fisher ER, Wickerham DL, Begovic M, DeCillis A, Robidoux A, Margolese RG, Cruz AB Jr, Hoehn JL, Lees AW, Dimitrov NV, Bear HD. Effect of preoperative chemotherapy on the outcome of women with operable breast cancer. J Clin Oncol. 1998;16:2672–85.",{"doi":2009},"10.1200\u002FJCO.1998.16.8.2672",{"id":22,"text":2011,"url":22,"identifiers":2012},"van der Hage JA, van de Velde CJ, Julien JP, Tubiana-Hulin M, Vandervelden C, Duchateau L. Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treatment of Cancer trial 10902. J Clin Oncol. 2001;19:4224–37.",{"doi":2013},"10.1200\u002FJCO.2001.19.22.4224",{"id":22,"text":2015,"url":22,"identifiers":2016},"Green M, Hortobagyi GN. Neoadjuvant chemotherapy for operable breast cancer. Oncology. 2002;16:871–98.",{},{"id":22,"text":2018,"url":22,"identifiers":2019},"Wang J, Buchholz TA, Middleton LP, Allred DC, Tucker SL, Kuerer HM, Esteva FJ, Hortobagyi GN, Sahin AA. Assessment of histologic features and expression of biomarkers in predicting pathologic response to anthracycline-based neoadjuvant chemotherapy in patients with breast carcinoma. Cancer. 2002;94:3107–14.",{"doi":2020},"10.1002\u002Fcncr.10585",{"id":22,"text":2022,"url":22,"identifiers":2023},"Kuerer HM, Newman LA, Smith TL, Ames FC, Hunt KK, Dhingra K, Theriault RL, Singh G, Binkley SM, Sneige N, Buchholz TA, Ross MI, McNeese MD, Buzdar AU, Hortobagyi GN, Singletary SE. Clinical course of breast cancer patients with complete pathologic primary tumor and axillary lymph node response to doxorubicin-based neoadjuvant chemotherapy. J Clin Oncol. 1999;17:460–9.",{"doi":2024},"10.1200\u002FJCO.1999.17.2.460",{"id":22,"text":2026,"url":22,"identifiers":2027},"Valero V, Buzdar AU, McNeese M, Singletary E, Hortobagyi GN. Primary chemotherapy in the treatment of breast cancer: the University of Texas M. D. Anderson Cancer Center experience. Clin Breast Cancer. 2002;3(suppl 2):S63–8.",{"doi":2028},"10.3816\u002FCBC.2002.s.014",{"id":22,"text":2030,"url":22,"identifiers":2031},"Kuroi K, Toi M, Tsuda H, Kurosumi M, Akiyama F. Issues in the assessment of the pathologic effect of primary systemic therapy for breast cancer. Breast Cancer. 2006;13:38–48.",{"doi":2032},"10.2325\u002Fjbcs.13.38",{"id":22,"text":2034,"url":22,"identifiers":2035},"Smith IC, Miller ID. Issues involved in research into the neoadjuvant treatment of breast cancer. Anticancer Drugs. 2001;12(suppl 1):S25–9.",{},{"id":22,"text":2037,"url":22,"identifiers":2038},"Sataloff DM, Mason BA, Prestipino AJ, Seinige UL, Lieber CP, Baloch Z. Pathologic response to induction chemotherapy in locally advanced carcinoma of the breast: a determinant of outcome. J Am Coll Surg. 1995;180:297–306.",{},{"id":22,"text":2040,"url":22,"identifiers":2041},"Bear HD, Anderson S, Brown A, Smith R, Mamounas EP, Fisher B, Margolese R, Theoret H, Soran A, Wickerham DL, Wolmark N. The effect on tumor response of adding sequential preoperative docetaxel to preoperative doxorubicin and cyclophosphamide: preliminary results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27. J Clin Oncol. 2003;21:4165–74.",{"doi":2042},"10.1200\u002FJCO.2003.12.005",{"id":22,"text":2044,"url":22,"identifiers":2045},"Fisher B, Brown A, Mamounas E, Wieand S, Robidoux A, Margolese RG, Cruz AB Jr, Fisher ER, Wickerham DL, Wolmark N, DeCillis A, Hoehn JL, Lees AW, Dimitrov NV. Effect of preoperative chemotherapy on local-regional disease in women with operable breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-18. J Clin Oncol. 1997;15:2483–93.",{"doi":2046},"10.1200\u002FJCO.1997.15.7.2483",{"id":22,"text":2048,"url":22,"identifiers":2049},"Machiavelli MR, Romero AO, Perez JE, Lacava JA, Dominguez ME, Rodriguez R, Barbieri MR, Romero Acuna LA, Romero Acuna JM, Langhi MJ, Amato S, Ortiz EH, Vallejo CT, Leone BA. Prognostic significance of pathological response of primary tumor and metastatic axillary lymph nodes after neoadjuvant chemotherapy for locally advanced breast carcinoma. Cancer J Sci Am. 1998;4:125–31.",{},{"id":22,"text":2051,"url":22,"identifiers":2052},"Rouzier R, Extra JM, Klijanienko J, Falcou MC, Asselain B, Vincent-Salomon A, Vielh P, Bourstyn E. Incidence and prognostic significance of complete axillary downstaging after primary chemotherapy in breast cancer patients with T1 to T3 tumors and cytologically proven axillary metastatic lymph nodes. J Clin Oncol. 2002;20:1304–10.",{"doi":2053},"10.1200\u002FJCO.2002.20.5.1304",{"id":22,"text":2055,"url":22,"identifiers":2056},"Hennessy BT, Hortobagyi GN, Rouzier R, Kuerer H, Sneige N, Buzdar AU, Kau SW, Fornage B, Sahin A, Broglio K, Singletary SE, Valero V. Outcome after pathologic complete eradication of cytologically proven breast cancer axillary node metastases following primary chemotherapy. J Clin Oncol. 2005;23:9304–11.",{"doi":2057},"10.1200\u002FJCO.2005.02.5023",{"id":22,"text":2059,"url":22,"identifiers":2060},"Kai K, Nishimura R, Arima N, Miyayama H, Iwase H. p53 expression status is a significant molecular marker in predicting the time to endocrine therapy failure in recurrent breast cancer: a cohort study. Int J Clin Oncol. 2006;11:426–33.",{"doi":2061},"10.1007\u002Fs10147-006-0601-6",{"id":22,"text":2063,"url":22,"identifiers":2064},"Kurosumi M. Significance and problems in evaluations of pathological responses to neoadjuvant therapy for breast cancer. Breast Cancer. 2006;13:254–9.",{"doi":2065},"10.2325\u002Fjbcs.13.254",{"id":22,"text":2067,"url":22,"identifiers":2068},"Sachelarie I, Grossbard ML, Chadha M, Feldman S, Ghesani M, Blum RH. Primary systemic therapy of breast cancer. Oncologist. 2006;11:574–89.",{"doi":2069},"10.1634\u002Ftheoncologist.11-6-574",{"id":22,"text":2071,"url":22,"identifiers":2072},"Heys SD, Sarkar T, Hutcheon AW. Primary docetaxel chemotherapy in patients with breast cancer: impact on response and survival. Breast Cancer Res Treat. 2005;90:169–85.",{"doi":2073},"10.1007\u002Fs10549-004-1001-0",{"id":22,"text":2075,"url":22,"identifiers":2076},"de Matteis A, Nuzzo F, D’Aiuto G, Labonia V, Landi G, Rossi E, Mastro AA, Botti G, De Maio E, Perrone F. Docetaxel plus epidoxorubicin as neoadjuvant treatment in patients with large operable or locally advanced carcinoma of the breast: a single-center, phase II study. Cancer. 2002;94:895–901.",{"doi":2077},"10.1002\u002Fcncr.20335",{"id":22,"text":2079,"url":22,"identifiers":2080},"Kuerer HM, Newman LA, Buzdar AU, Hunt KK, Dhingra K, Buchholz TA, Binkley SM, Ames FC, Feig BW, Ross MI, Hortobagyi GN, Singletary SE. Residual metastatic axillary lymph nodes following neoadjuvant chemotherapy predict disease-free survival in patients with locally advanced breast cancer. Am J Surg. 1998;176:502–9.",{"doi":2081},"10.1016\u002FS0002-9610(98)00253-0",{"id":22,"text":2083,"url":22,"identifiers":2084},"van Beers EH, Nederlof PM. Array-CGH and breast cancer. Breast Cancer Res. 2006;8:210.",{"doi":2085},"10.1186\u002Fbcr1510",{"id":22,"text":2087,"url":22,"identifiers":2088},"Gonzalez-Angulo AM, McGuire SE, Buchholz TA, Tucker SL, Kuerer HM, Rouzier R, Kau SW, Huang EH, Morandi P, Ocana A, Cristofanilli M, Valero V, Buzdar AU, Hortobagyi GN. Factors predictive of distant metastases in patients with breast cancer who have a pathologic complete response after neoadjuvant chemotherapy. J Clin Oncol. 2005;23:7098–104.",{"doi":2089},"10.1200\u002FJCO.2005.11.124",{"id":2091,"createTime":2092,"updateTime":2093,"relativeEntities":2094,"slug":2095,"properties":2096,"entityType":251,"verifyStatus":252,"verifyTime":2093,"verifyNote":253,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"primaryUrl":2105,"fullTextUrl":22,"authors":2106,"publicationType":525,"publisherRelationship":2198,"citationCount":22,"citationInfo":22,"publishDate":2233,"publishYear":2234,"citationAnalyzeStatus":21,"lastCitationAnalyze":22,"indexDatabases":22,"openAccess":22,"references":22,"isForceReanalyzing":563},"43e38192-d700-434a-813a-d2933934fec2","2024-02-07T01:57:36.628+00:00","2024-08-30T23:54:13.205+00:00",[],"Ti-Breast-Cancer-Associated-with-Von-Recklinghausen-s-Neurofibromatosis",{"references":2097,"abstract":2099,"title":2101,"doi":2103},{"VOID":2098},"Sakai A, Suzuki K: von Recklinghausen’s disease and its pathogenesis.Nippon Rinsho 53:2688–2690, 1995(in Japanese with English abstract).\nMarchuk D, Saulino AM, Tavakkol R,et al: cDNA cloning of the NF1; Complete sequence of NF1.Genomics 11:931–940, 1991.\nMarshall CJ: Tumor suppressor genes.Cell 64:313–326, 1991.\nSorensen SA, Mulvihill JJ, Nielsen A: Long-term follow-up of von Recklinghausen neurofibromatosis; Survival and malignant neoplasms.N Engl] Med 314:1010–1015, 1986.\nYaegashi S, Sachse R, Ohuchi N,et al: Low incidence of a nucleotide sequence alteration of the neurofibromatosis 2 gene in human breast cancers.Jpn J Cancer Res 86:929–933, 1995.\nArakawa H, Hayashi N, Nagase H,et al: Alternative splicing of the NF2 gene and its mutation analysis of breast and colorectal cancers.Hum Mol Genet 3:565–568, 1994.\nKanai Y, Tsuda H, Oda T,et al: Analysis of the neurofibromatosis 2 gene in human breast and hepatocellular carcinomas.Jpn J Clin Oncol 25:1–4, 1995.\nSherman JE, Smith JW: Neurofibromas of the breast and nipple-areolar area.Ann Plastic Surg 7:302–307, 1981.\nBader JL: Neurofibromatosis and cancer.Ann NY Acad Sci 486:57–65, 1986.\nRiccardi VM: Von Recklinghausen Neurofibromatosis.N Engl J Med 305:1617–1627, 1981.\nel-Zawahry, Fraid M, Abd el-Latif A,et al: Breast lesions in generalized neurofibromatosis breast cancer and cystosarcoma phylloides.Neurofibromatosis 2:121–124, 1989.\nVilar Sanchis D, Vazquez Albaladejo C: Von Recklinghausen’s neurofibromatosis (letter).Eur J Surg Oncol 18:202–203, 1992.\nSato R, Kimura Y, Kato E: A case of breast cancer associated with von Recklinghausen’'s disease.Jpn J Clin Surg 57:328–332, 1996(in Japanese with English abstract).\nOsada K, Goto T, Taguchi T,et al: A case of breast cancer associated with von Recklinghausen’s disease.J Minami-Osaka Med 45:167–173, 1997(in Japanese with English abstract).\nSako H, Akashi I, Oita Y,et al: A case of intracystic carcinoma of the breast associated with von Recklinghausen’s disease.Med Postgraduates 35:64–67, 1997(in Japanese).\nSuzuki A, Kameyama J, Sakai Y,et al: A rare case of double cancer of the breast and colon associated with von Recklinghausen’s disease.Jpn J Clin Surg 58:1396–1400, 1997(in Japanese with English abstract).",{"EN":2100},"A rare case of breast cancer associated with von Recklinghausen’s neurofibromatosis is reported. This case and review of the literature illustrate the problems of clinical diagnosis. A 66-year-old woman who had undergone sigmoidectomy for sigmoid colon cancer two years previously, was admitted to the hospital because of a left breast skin retraction in October, 1998. The patient had von Recklinghausen’s disease (neurofibromatosis type 1). The TNM clinical staging was TlcNOMO. Modified radical mastectomy was performed. The histopathological diagnosis of the breast tumor was invasive ductal carcinoma and the skin tumor was neurofibroma. The pTNM pathological staging was pTlcNlaMO. Among patients similar to our case, almost all were staged higher than T2. This may be because multiple neurofibromas obscure breast mass at palpation, leading to delayed detection of the cancer. Systemic and careful exploration is essential for patients with von Recklinghausen’s neurofibromatosis to detect breast cancer at an early stage.",{"EN":2102},"Ti Breast Cancer Associated with Von Recklinghausen’s Neurofibromatosis",{"VOID":2104},"10.1007\u002FBF02967173","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002FBF02967173",[2107,2124,2135,2147,2159,2174,2186],{"id":2108,"sortIndex":175,"researcher":22,"roles":2109,"affiliations":2110,"properties":2121},"04b1d68a-620a-49fc-9777-0a0f2ff03547",[259],[2111],{"id":22,"sortIndex":23,"affiliation":2112,"properties":22},{"id":2113,"createTime":2114,"updateTime":2115,"relativeEntities":2116,"slug":2117,"properties":2118,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"07d87d8c-5f16-4d25-804b-0ec6d4e7a42c","2024-02-07T01:57:36.659+00:00","2025-06-11T20:52:07.608+00:00",[],"Department-of-Surgery-Nerima-General-Hospital-Japan",{"title":2119},{"VI":2120},"Department of Surgery, Nerima General Hospital, Japan",{"title":2122},{"VI":2123},"Naoki Shimojima",{"id":2125,"sortIndex":376,"researcher":22,"roles":2126,"affiliations":2127,"properties":2133},"47152006-0c76-46d1-a020-2637ce46956c",[259],[2128],{"id":22,"sortIndex":23,"affiliation":2129,"properties":22},{"id":2113,"createTime":2114,"updateTime":2115,"relativeEntities":2130,"slug":2117,"properties":2131,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":2132},{"VI":2120},{"title":2134},{"VI":1965},{"id":2136,"sortIndex":199,"researcher":22,"roles":2137,"affiliations":2138,"properties":2144},"4955635e-61fe-4f45-897c-a24f0a3e1057",[259],[2139],{"id":22,"sortIndex":23,"affiliation":2140,"properties":22},{"id":2113,"createTime":2114,"updateTime":2115,"relativeEntities":2141,"slug":2117,"properties":2142,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":2143},{"VI":2120},{"title":2145},{"VI":2146},"Kaichiro Kikuchi",{"id":2148,"sortIndex":292,"researcher":22,"roles":2149,"affiliations":2150,"properties":2156},"85b5c815-bced-4529-8b0d-1fd8d518f740",[259],[2151],{"id":22,"sortIndex":23,"affiliation":2152,"properties":22},{"id":2113,"createTime":2114,"updateTime":2115,"relativeEntities":2153,"slug":2117,"properties":2154,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":2155},{"VI":2120},{"title":2157},{"VI":2158},"Shuhei lida",{"id":2160,"sortIndex":68,"researcher":22,"roles":2161,"affiliations":2162,"properties":2171},"6b059c54-e8e6-4dd3-8969-b42ae7b29234",[259],[2163],{"id":22,"sortIndex":23,"affiliation":2164,"properties":22},{"id":2165,"createTime":2166,"updateTime":2166,"relativeEntities":2167,"slug":22,"properties":2168,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},"f3792928-4624-4231-acb6-01649ab93ba6","2024-02-07T01:57:36.713+00:00",[],{"title":2169},{"VI":2170},"Departments of Pathology, Nerima General Hospital, Japan",{"title":2172},{"VI":2173},"Yasuko Kondo",{"id":2175,"sortIndex":23,"researcher":22,"roles":2176,"affiliations":2177,"properties":2183},"508ea09b-591a-4297-8c95-00584387c0aa",[259],[2178],{"id":22,"sortIndex":23,"affiliation":2179,"properties":22},{"id":2113,"createTime":2114,"updateTime":2115,"relativeEntities":2180,"slug":2117,"properties":2181,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":2182},{"VI":2120},{"title":2184},{"VI":2185},"Yoshihiko Murayama",{"id":2187,"sortIndex":200,"researcher":22,"roles":2188,"affiliations":2189,"properties":2195},"5699d3f1-b43a-414f-810a-66f9d4f1031c",[259],[2190],{"id":22,"sortIndex":23,"affiliation":2191,"properties":22},{"id":2113,"createTime":2114,"updateTime":2115,"relativeEntities":2192,"slug":2117,"properties":2193,"entityType":67,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23},[],{"title":2194},{"VI":2120},{"title":2196},{"VI":2197},"Tetsuya Takahara",{"url":2105,"publisher":2199,"properties":2228},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2200,"slug":10,"properties":2201,"entityType":20,"verifyStatus":21,"verifyTime":22,"verifyNote":22,"syncStatus":21,"languages":22,"translateLanguages":22,"viewCount":23,"subjectFields":2206,"manageAffiliations":2207,"indexDatabases":2208,"url":22,"thumbnailPath":22,"statistic":2223,"gsStatistic":22,"type":231,"analyzePriority":22},[],{"issn":2202,"eissn":2203,"title":2204,"url":2205},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},[],[],[2209,2216],{"id":84,"indexDatabase":2210,"url":97,"indexYears":98,"academicFieldIds":2215,"indexDatabaseRanking":104},{"id":86,"createTime":87,"updateTime":88,"relativeEntities":2211,"label":2212,"description":2213,"key":94,"publicationTags":2214,"standard":22},[],{"EN":91,"VI":91},{"EN":91,"VI":93},[96],[100,101,102,103],{"id":106,"indexDatabase":2217,"url":121,"indexYears":22,"academicFieldIds":2222,"indexDatabaseRanking":22},{"id":108,"createTime":109,"updateTime":110,"relativeEntities":2218,"label":2219,"description":2220,"key":117,"publicationTags":2221,"standard":22},[],{"EN":113,"VI":113},{"VI":115,"EN":116},[119,120],[123,124],{"impactFactor":23,"impactFactorByYear":2224,"i10Index":140,"i10IndexLast5Year":141,"totalPublication":142,"totalPublicationByYear":2225,"totalCitation":171,"totalCitationByYear":2226,"totalCitationPerPublication":201,"totalCitationPerPublicationByYear":2227,"hindexLast5Year":230,"hindex":230},{"2008":127,"2009":128,"2012":129,"2013":130,"2014":131,"2015":132,"2016":131,"2017":133,"2018":134,"2019":135,"2020":136,"2021":137,"2022":138,"2023":139},{"1994":144,"1995":145,"1996":146,"1997":147,"1998":148,"1999":149,"2000":149,"2001":147,"2002":150,"2003":151,"2004":150,"2005":152,"2006":153,"2007":154,"2008":155,"2009":156,"2010":157,"2011":153,"2012":158,"2013":159,"2014":160,"2015":161,"2016":162,"2017":163,"2018":164,"2019":165,"2020":166,"2021":167,"2022":168,"2023":169,"2024":170},{"1994":173,"1995":174,"1996":175,"1997":176,"1998":177,"1999":178,"2000":179,"2001":180,"2002":181,"2003":182,"2004":183,"2005":184,"2006":185,"2007":186,"2008":187,"2009":188,"2010":189,"2011":157,"2012":190,"2013":191,"2014":192,"2015":193,"2016":183,"2017":194,"2018":184,"2019":195,"2020":196,"2021":197,"2022":198,"2023":199,"2024":200},{"1994":203,"1995":204,"1996":205,"1997":206,"1998":207,"1999":130,"2000":208,"2001":209,"2002":210,"2003":201,"2004":211,"2005":212,"2006":213,"2007":214,"2008":215,"2009":216,"2010":217,"2011":218,"2012":219,"2013":175,"2014":220,"2015":221,"2016":222,"2017":223,"2018":224,"2019":225,"2020":226,"2021":227,"2022":228,"2023":229,"2024":205},{"volume":2229,"pages":2231},{"VOID":2230},"6",{"VOID":2232},"227-230","1999-07-01",1999]