[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"_public_publisher_byId_ba42afb8-2cea-4377-85de-77fca25f80ad":3,"_public_publication_all{\"sortAscending\":false,\"sortField\":\"updateTime\",\"page\":0,\"size\":10,\"facet\":true,\"searchKey\":\"publisherId:ba42afb8-2cea-4377-85de-77fca25f80ad,\"}":113},{"code":4,"data":5,"meta":24},"SUCCESS",{"id":6,"createTime":7,"updateTime":8,"relativeEntities":9,"slug":10,"properties":11,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":26,"manageAffiliations":35,"indexDatabases":57,"url":96,"thumbnailPath":24,"statistic":97,"gsStatistic":24,"type":24,"analyzePriority":24},"ba42afb8-2cea-4377-85de-77fca25f80ad","2023-05-29T10:37:26.656+00:00","2025-11-21T09:54:55.549+00:00",[],"Brazilian-Journal-of-Pharmaceutical-Sciences",{"country":12,"issn":14,"introduce":16,"eissn":18,"title":20},{"VOID":13},"BR",{"VOID":15},"19848250",{"EN":17},"The Brazilian Journal of Pharmaceutical Sciences accepts for publication Original Papers applicable to the fields of Pharmaceutical Sciences; Reviews and Current Comment Articles, which are published under the Scientific Editor and Associate Editors invitation to recognized experts or when they are spontaneously submitted by the authors in the form of abstracts to have their importance evaluated. A critical view of the subject with insertions of results of previous works in the field in relation to the state of art must be included; Short Communications reporting new methods and previews of works on researches of outstanding importance in which originality justify a quick publication. A maximum of 2000 words excluding tables, figures and references is an acceptable limit. One table, one figure and ten references may be added, and Book Reviews of the latest editions of books, prepared by specialists invited by the Scientific Editor and Associate Editors. Thematic Supplements as well as those related to scientific meetings can be published under the Scientific Editor and\u002For Associate Editors agreement.",{"VOID":19},"21759790",{"EN":21},"Brazilian Journal of Pharmaceutical Sciences","PUBLISHER","PENDING",null,0,[27],{"id":28,"createTime":29,"updateTime":30,"relativeEntities":31,"label":32,"description":34,"parentId":24,"standard":24,"scholarHubFieldId":24},"946fd3a4-a836-4df1-8622-93deedadaad7","2023-05-29T10:24:53.374+00:00","2023-11-21T06:11:52.066+00:00",[],{"EN":33},"Pharmacology, Toxicology and Pharmaceutics (miscellaneous)",{},[36,47],{"id":37,"createTime":38,"updateTime":39,"relativeEntities":40,"slug":41,"properties":42,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"url":24,"parentIds":46,"statistic":24},"d0d4e121-4657-4e7d-be96-a599650ac303","2023-05-29T10:37:26.571+00:00","2023-12-21T11:39:56.192+00:00",[],"Faculdade-de-Ciencias-Farmaceuticas-Biblioteca-",{"title":43},{"EN":44},"Faculdade de Ciencias Farmaceuticas (Biblioteca-","AFFILIATION",[],{"id":48,"createTime":49,"updateTime":50,"relativeEntities":51,"slug":52,"properties":53,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"url":24,"parentIds":56,"statistic":24},"926a16fd-0cf0-489f-928d-01f200c96f54","2023-05-29T12:14:43.427+00:00","2023-12-21T11:41:28.803+00:00",[],"UNIV-SAO-PAULO-CONJUNTO-QUIMICAS",{"title":54},{"EN":55},"UNIV SAO PAULO, CONJUNTO QUIMICAS",[],[58,77],{"id":59,"indexDatabase":60,"url":74,"indexYears":24,"academicFieldIds":75,"indexDatabaseRanking":24},"95056d76-36d1-48c3-a651-3eb326cab106",{"id":61,"createTime":62,"updateTime":63,"relativeEntities":64,"label":65,"description":67,"key":70,"publicationTags":71,"standard":24},"a4921856-b128-4d9f-8f1f-e80813d3bbd4","2023-05-22T09:59:31.026+00:00","2025-11-21T10:07:52.153+00:00",[],{"EN":66,"VI":66},"ISI\u002FSCIE - Science Citation Index Expanded",{"VI":68,"EN":69},"Cơ sở dữ liệu SCIE","SCIE database","scie",[72,73],"SCIE","ISI","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results?issn=1984-8250",[76],"2b943d65-24a8-4546-9232-a1e32c12cb6c",{"id":78,"indexDatabase":79,"url":91,"indexYears":92,"academicFieldIds":93,"indexDatabaseRanking":95},"1158d852-b0cd-4d9a-9a03-376cd200c75c",{"id":80,"createTime":81,"updateTime":82,"relativeEntities":83,"label":84,"description":86,"key":88,"publicationTags":89,"standard":24},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9","2023-05-22T09:57:18.509+00:00","2025-11-21T10:07:52.274+00:00",[],{"EN":85,"VI":85},"Scopus - Elsevier",{"EN":85,"VI":87},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[90],"SCOPUS","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F19700182901","2009-2025",[94],"1cbb0935-4bf6-4f4f-9e5b-4f08260835a4","SCOPUS__Q3","http:\u002F\u002Fwww.revistas.usp.br\u002Fbjps",{"impactFactor":25,"impactFactorByYear":98,"i10Index":100,"i10IndexLast5Year":25,"totalPublication":101,"totalPublicationByYear":102,"totalCitation":105,"totalCitationByYear":106,"totalCitationPerPublication":110,"totalCitationPerPublicationByYear":111,"hindexLast5Year":100,"hindex":100},{"2012":99},2.67,4,5,{"2010":103,"2011":104,"2013":104},2,1,127,{"2010":107,"2011":108,"2013":109},95,11,19,25.4,{"2010":112,"2011":108,"2013":109},47.5,{"meta":114,"data":116},{"total":115},"9",[117,450,636,904,1149,1442,1739,1922,2129],{"id":118,"createTime":119,"updateTime":119,"relativeEntities":120,"slug":121,"properties":122,"entityType":134,"verifyStatus":135,"verifyTime":136,"verifyNote":137,"syncStatus":23,"languages":138,"translateLanguages":24,"viewCount":25,"primaryUrl":140,"fullTextUrl":24,"authors":141,"publicationType":201,"publisherRelationship":202,"citationCount":240,"citationInfo":241,"publishDate":245,"publishYear":246,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":247,"isForceReanalyzing":449},"9786ad02-511d-4608-b137-2431f12434b5","2024-09-27T22:32:03.481+00:00",[],"Pharmaceutical-properties-of-sucupira-Pterodon-spp-",{"mag":123,"keywords":125,"openalex":126,"abstract":128,"title":130,"doi":132},{"VOID":124},"1933607058",{},{"VOID":127},"W1933607058",{"EN":129},"\u003Cjats:p>The plant of the genus Pterodon (Fabaceae, Leguminosae), commonly known as 'sucupira' or 'faveira', are disseminated throughout the central region of Brazil and has frequently been used in popular medicine for its anti-rheumatic, analgesic, and anti-inflammatory properties. In recent years, interest in these plants has increased considerably. The biological effects of different phytoextracts and pure metabolites have been investigated in several experimental models in vivo and in vitro. The literature describes flavonoids, triterpene and steroids, while one paper presented studies with proteins isolated from the genus. This review provides an overview of phytochemical and pharmacological research in Pterodon, showing the main chemical compounds studied to date, and focusing on the relationship between these molecules and their biological activity. Furthermore, this study paves the way for more in-depth investigation, isolation and characterization of the molecules of this plant genus.\u003C\u002Fjats:p>",{"EN":131},"Pharmaceutical properties of 'sucupira' (Pterodon spp.)",{"VOID":133},"10.1590\u002Fs1984-82502010000400002","PUBLICATION","VERIFIED","2024-09-27T22:32:03.480+00:00","Auto Verify",[139],"EN","http:\u002F\u002Fwww.scielo.br\u002Fscielo.php?script=sci_arttext&pid=S1984-82502010000400002&lng=en&tlng=en",[142,161,182],{"id":143,"sortIndex":25,"researcher":24,"roles":144,"affiliations":145,"properties":156},"b94c4440-0442-42f8-afa7-cc3f43056ea6",[],[146],{"id":147,"sortIndex":25,"affiliation":148,"properties":24},"0605476a-483a-4375-b512-6589e6528e4b",{"id":149,"createTime":150,"updateTime":150,"relativeEntities":151,"slug":152,"properties":153,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"5c20067c-5322-4c08-848e-4557d732cd80","2024-09-27T22:32:03.499+00:00",[],"University-Federal-of-Goi%C3%A1s-Biological-Institute-of-S%C3%A3o-Paulo",{"title":154},{"EN":155},"University Federal of Goiás; Biological Institute of São Paulo",{"openalex":157,"title":159},{"VOID":158},"A5038649173",{"EN":160},"Daiane Hansen",{"id":162,"sortIndex":103,"researcher":24,"roles":163,"affiliations":164,"properties":175},"f0760603-36a4-44d0-a51f-ee1fd46e6092",[],[165],{"id":166,"sortIndex":25,"affiliation":167,"properties":24},"b620b185-bd6c-4865-bb53-f9639f4c95e6",{"id":168,"createTime":169,"updateTime":169,"relativeEntities":170,"slug":171,"properties":172,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"fc99337c-0446-48f8-a275-6784117af0ed","2024-09-27T22:32:03.526+00:00",[],"University-Federal-of-Goi%C3%A1s",{"title":173},{"EN":174},"University Federal of Goiás",{"openalex":176,"orcid":178,"title":180},{"VOID":177},"A5068031802",{"VOID":179},"https:\u002F\u002Forcid.org\u002F0000-0003-4768-6372",{"EN":181},"Antônio Alonso",{"id":183,"sortIndex":104,"researcher":24,"roles":184,"affiliations":185,"properties":196},"b4dbca13-f404-4d28-8ce9-28524670ebe4",[],[186],{"id":187,"sortIndex":25,"affiliation":188,"properties":24},"48ed08ea-a053-472b-b06e-8414e6f68628",{"id":189,"createTime":190,"updateTime":190,"relativeEntities":191,"slug":192,"properties":193,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"8183ac82-c87f-4a1c-a41d-6efd9860717c","2024-09-27T22:32:03.512+00:00",[],"Biological-Institute-of-S%C3%A3o-Paulo",{"title":194},{"EN":195},"Biological Institute of São Paulo",{"openalex":197,"title":199},{"VOID":198},"A5023536887",{"EN":200},"Mitsue Haraguchi","ARTICLE",{"url":24,"publisher":203,"properties":233},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":204,"slug":10,"properties":205,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":211,"manageAffiliations":212,"indexDatabases":213,"url":96,"thumbnailPath":24,"statistic":228,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":206,"issn":207,"introduce":208,"eissn":209,"title":210},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[214,221],{"id":78,"indexDatabase":215,"url":91,"indexYears":92,"academicFieldIds":220,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":216,"label":217,"description":218,"key":88,"publicationTags":219,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"id":59,"indexDatabase":222,"url":74,"indexYears":24,"academicFieldIds":227,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":223,"label":224,"description":225,"key":70,"publicationTags":226,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"impactFactor":25,"impactFactorByYear":229,"i10Index":100,"i10IndexLast5Year":25,"totalPublication":101,"totalPublicationByYear":230,"totalCitation":105,"totalCitationByYear":231,"totalCitationPerPublication":110,"totalCitationPerPublicationByYear":232,"hindexLast5Year":100,"hindex":100},{"2012":99},{"2010":103,"2011":104,"2013":104},{"2010":107,"2011":108,"2013":109},{"2010":112,"2011":108,"2013":109},{"volume":234,"pages":236,"issue":238},{"VOID":235},"46",{"VOID":237},"607-616",{"VOID":239},"4",36,{"total":240,"publishYear":24,"statisticByYear":242},{"2012":101,"2013":103,"2014":103,"2015":243,"2016":104,"2017":244,"2018":104,"2019":104,"2020":103,"2021":243,"2022":101,"2023":101},3,6,"2010-12-01",2010,[248,252,255,259,263,266,270,274,278,282,285,289,292,296,300,304,308,311,314,317,321,324,328,332,336,339,343,347,350,354,358,362,365,369,372,375,378,382,386,390,394,397,401,404,407,411,415,419,423,426,430,434,438,441,445],{"id":24,"text":249,"url":24,"identifiers":250},"ALMEIDA M.E.L, 1975, Further isoflavones, Pterodon apparicioi. Phytochemistry, 14, 2716, 10.1016\u002F0031-9422(75)85263-0",{"doi":251},"10.1016\u002F0031-9422(75)85263-0",{"id":24,"text":253,"url":24,"identifiers":254},"ARAÚJO A.P.U, 2005, Kunitz type Bauhinia bauhinioides inhibitors devoid of disulfide bridges: isolation of the cDNAs, heterologous expression and structural studies, Biol. Chem, 386, 561",{},{"id":24,"text":256,"url":24,"identifiers":257},"ARRIAGA A.M.C, 2000, Further diterpenoids isolated from Pterodon polygalaeflorus, J. Braz. Chem. Soc.,, 11, 187, 10.1590\u002FS0103-50532000000200015",{"doi":258},"10.1590\u002FS0103-50532000000200015",{"id":24,"text":260,"url":24,"identifiers":261},"BASSO L.A, 2005, The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases- a review, Mem. Inst. Oswaldo Cruz, 100, 575, 10.1590\u002FS0074-02762005000600001",{"doi":262},"10.1590\u002FS0074-02762005000600001",{"id":24,"text":264,"url":24,"identifiers":265},"BRAZ FILHO R, Chemistry of Brazilian Leguminosae, XXXIV Isoflavones of Pterodon pubescens. Phytochemistry, 10, 2835",{},{"id":24,"text":267,"url":24,"identifiers":268},"CALIXTO N.O, 2007, Antiplatelet activity of geranylgeraniol isolated from Pterodon pubescens fruit oil is mediated by inhibition of cyclooxigenase-1, Planta Med, 73, 480, 10.1055\u002Fs-2007-967177",{"doi":269},"10.1055\u002Fs-2007-967177",{"id":24,"text":271,"url":24,"identifiers":272},"CAMPOS A.M, 1994, Diterpenoids from Pterodon polygalaeflorus, Phytochemistry, 36, 403, 10.1016\u002FS0031-9422(00)97084-5",{"doi":273},"10.1016\u002FS0031-9422(00)97084-5",{"id":24,"text":275,"url":24,"identifiers":276},"CARDOSO C.C, 2008, Suppression of T and B cell responses by Pterodon pubescens seeds ethanolic extract, Pak. J. Biol. Sci, 11, 2308, 10.3923\u002Fpjbs.2008.2308.2313",{"doi":277},"10.3923\u002Fpjbs.2008.2308.2313",{"id":24,"text":279,"url":24,"identifiers":280},"CARVALHO J.C.T, 1999, Anti-inflammatory activity of the crude extract from the fruits of Pterodon emarginatus Vog, J. Ethnopharmacol, 64, 127, 10.1016\u002FS0378-8741(98)00116-0",{"doi":281},"10.1016\u002FS0378-8741(98)00116-0",{"id":24,"text":283,"url":24,"identifiers":284},"CARVALHO J.C.T., 2004, Sucupira, Pterodon emarginatus Vog, 383",{},{"id":24,"text":286,"url":24,"identifiers":287},"COELHO M.G.P, 2001, Subacute toxicity evaluation of a hydroalcoholic extract of Pterodon pubescens seeds in mice with collagen-induced arthritis, J. Ethnopharmacol, 77, 159, 10.1016\u002FS0378-8741(01)00288-4",{"doi":288},"10.1016\u002FS0378-8741(01)00288-4",{"id":24,"text":290,"url":24,"identifiers":291},"COELHO M.G, 2004, Immunomodulatory effects of sucupira (Pterodon pubescens) seed infusion on collagen-induced arthritis, Clin. Exp. Rheumatol, 22, 213",{},{"id":24,"text":293,"url":24,"identifiers":294},"COELHO L.P, 2005, Anti-nociceptive properties of ethanolic extract and fractions of Pterodon pubescens Benth. seeds, J. Ethnopharmacol, 98, 109, 10.1016\u002Fj.jep.2005.01.014",{"doi":295},"10.1016\u002Fj.jep.2005.01.014",{"id":24,"text":297,"url":24,"identifiers":298},"DE OMENA M.C, 2006, Larvicidal diterpenes from Pterodon polygalaeflorus, Vector Borne Zoonotic Dis, 6, 216, 10.1089\u002Fvbz.2006.6.216",{"doi":299},"10.1089\u002Fvbz.2006.6.216",{"id":24,"text":301,"url":24,"identifiers":302},"DEMUNER A.J, 1996, Structure and plant growth regulatory activity of new diterpenes from Pterodon polygalaeflorus, J.Nat.Prod, 59, 770, 10.1021\u002Fnp960140f",{"doi":303},"10.1021\u002Fnp960140f",{"id":24,"text":305,"url":24,"identifiers":306},"DIAS F. D, 1995, Genotoxicity of the natural cercaricides \"sucupira\" oil and eremanthine in mammalian cells in vitro and in vivo, Environ. Mol. Mutagen, 26, 338, 10.1002\u002Fem.2850260410",{"doi":307},"10.1002\u002Fem.2850260410",{"id":24,"text":309,"url":24,"identifiers":310},"DOS SANTOS FILHO D, 1987, Chemoprophylactic activity of soaps containing essential oil from the fruits of Pterodon pubescens in Schistosomiasis mansoni, Mem. Inst. Oswaldo Cruz, 82, 343",{},{"id":24,"text":312,"url":24,"identifiers":313},"DOS SANTOS FILHO D, 1972, Prophylaxis of Schistosomiaris: Diterpenes from Pterodon pubescens, An. Acad. Bras. Ciênc, 44, 45",{},{"id":24,"text":315,"url":24,"identifiers":316},"DUARTE I.D.G, Possible participation of endogenous opioid peptides on the mechanism involved in analgesia induced by vouacapan, Life Sci, 50, 1992",{},{"id":24,"text":318,"url":24,"identifiers":319},"DUARTE I.D, 1996, Evidence of the involvement of biogenic amines in the anti-nociceptive effect of a vouacapan extracted from Pterodon polygalaeflorus Benth, J. Ethnopharmacol, 55, 13, 10.1016\u002FS0378-8741(96)01465-1",{"doi":320},"10.1016\u002FS0378-8741(96)01465-1",{"id":24,"text":322,"url":24,"identifiers":323},"DUTRA R.C, 2008, Anti-nociceptive activity of the essential oil and fractions of Pterodon emarginatus Vogel seeds, Lat. Am. J. Pharm, 27, 865",{},{"id":24,"text":325,"url":24,"identifiers":326},"DUTRA R.C, 2008, Quantification of Phenolic Constituents and Antioxidant Activity of Pterodon emarginatus Vogel seeds, Int. J. Mol. Sci., 9, 606, 10.3390\u002Fijms9040606",{"doi":327},"10.3390\u002Fijms9040606",{"id":24,"text":329,"url":24,"identifiers":330},"DUTRA R.C, 2009, Antimicrobial and leishmanicidal activities of seeds of Pterodon emarginatus, Braz. J. Pharmacogn, 19, 429, 10.1590\u002FS0102-695X2009000300016",{"doi":331},"10.1590\u002FS0102-695X2009000300016",{"id":24,"text":333,"url":24,"identifiers":334},"DUTRA R.C, 2009, Antiulcerogenic and anti-inflammatory activities of the essential oil from Pterodon emarginatus seeds, J. Pharm. Pharmacol, 61, 243, 10.1211\u002Fjpp.61.02.0015",{"doi":335},"10.1211\u002Fjpp.61.02.0015",{"id":24,"text":337,"url":24,"identifiers":338},"DUTRA R.C, 2009, Healing effect of Pterodon emarginatus seeds in experimental models of cutaneous ulcers in rabbits, Lat. Am. J. Pharm, 28, 375",{},{"id":24,"text":340,"url":24,"identifiers":341},"EUZEBIO F.P.G, 2009, Effect of6α, 7β-dihydroxyvouacapan-17β-oic acid and its lactone derivatives on the growth of human cancer cells., Bioorg. Chem, 37, 96, 10.1016\u002Fj.bioorg.2009.03.004",{"doi":342},"10.1016\u002Fj.bioorg.2009.03.004",{"id":24,"text":344,"url":24,"identifiers":345},"EVANGELISTA G.L, 2007, Essential oil of Pterodon polygalaeflorus inhibits electromechanical coupling on rat isolated trachea, J. Ethnopharmacol, 109, 515, 10.1016\u002Fj.jep.2006.08.028",{"doi":346},"10.1016\u002Fj.jep.2006.08.028",{"id":24,"text":348,"url":24,"identifiers":349},"FASCIO M, 1970, Two new diterpenes from Pterodon pubescens, An. Acad. Bras. Ciênc, 97",{},{"id":24,"text":351,"url":24,"identifiers":352},"FASCIO M, 1975, Diterpenoid furans from Pterodon species, Phytochemistry, 15, 201, 10.1016\u002FS0031-9422(00)89084-6",{"doi":353},"10.1016\u002FS0031-9422(00)89084-6",{"id":24,"text":355,"url":24,"identifiers":356},"GALINA E, 1974, Chemistry of Brazilian Leguminosae: XLVI Isoflavones from Pterodon appariciori, Phytochemistry, 13, 2593, 10.1016\u002FS0031-9422(00)86942-3",{"doi":357},"10.1016\u002FS0031-9422(00)86942-3",{"id":24,"text":359,"url":24,"identifiers":360},"HANSEN D, 2007, Crystal structure of a novel cysteinless plant Kunitz-type protease inhibitor, Biochem. Biophys. Res. Commun, 360, 735, 10.1016\u002Fj.bbrc.2007.06.144",{"doi":361},"10.1016\u002Fj.bbrc.2007.06.144",{"id":24,"text":363,"url":24,"identifiers":364},"KATZ N, 1993, Chemoprophylactic activity on Schistosomiasis mansoni of soaps containing essential oil from the fruits of Pterodon pubescens, Rev. Inst. Med. Trop, 35, 183",{},{"id":24,"text":366,"url":24,"identifiers":367},"LEAL L.K, 2000, Anti-nociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study, J. Ethnopharmacol, 70, 151, 10.1016\u002FS0378-8741(99)00165-8",{"doi":368},"10.1016\u002FS0378-8741(99)00165-8",{"id":24,"text":370,"url":24,"identifiers":371},"LEONHARDT V, 2010, 749",{},{"id":24,"text":373,"url":24,"identifiers":374},"MAHAJAN J.R, 1970, New diterpenoids from Pterodon emarginatus, An. Acad. Bras. Ciênc, 42, 103",{},{"id":24,"text":376,"url":24,"identifiers":377},"MAHAJAN J.R, 1972, New diterpenoids from Pterodon emarginatus, An. Acad. Bras. Ciênc, 44, 51",{},{"id":24,"text":379,"url":24,"identifiers":380},"MAHAJAN J.R, 1973, New diterpenoids from Pterodon emarginatus, J. Chem. Soc. Perkin Trans.I, 520, 10.1039\u002Fp19730000520",{"doi":381},"10.1039\u002Fp19730000520",{"id":24,"text":383,"url":24,"identifiers":384},"MARQUES D.D, 1998, Isoflavonoids and triterpenoids isolated from Pterodon polygalaeflorus, J. Braz. Chem. Soc, 9, 295, 10.1590\u002FS0103-50531998000300014",{"doi":385},"10.1590\u002FS0103-50531998000300014",{"id":24,"text":387,"url":24,"identifiers":388},"MENNA-BARRETO R.F.S, 2008, Anti-Trypanosoma cruzi activity of Pterodon pubescens seed oil: geranylgeraniol as the major bioactive component, Parasitol. Res., 103, 111, 10.1007\u002Fs00436-008-0937-0",{"doi":389},"10.1007\u002Fs00436-008-0937-0",{"id":24,"text":391,"url":24,"identifiers":392},"MORAES W.F, 2009, Anti-inflammatory and anti-nociceptive effects of Pterodon emarginatus stem bark alcohol extract, Pharm. Biol, 47, 146, 10.1080\u002F13880200802436117",{"doi":393},"10.1080\u002F13880200802436117",{"id":24,"text":395,"url":24,"identifiers":396},"MORS W.B, 1966, Ação profilática do óleo dos frutos de Sucupira-Branca, Pterodon pubescens Benth, contra a infecção pelo Schistosoma mansoni., An. Acad. Bras. Ciênc, 325",{},{"id":24,"text":398,"url":24,"identifiers":399},"MORS W.B, 1967, Chemoprophyloactic agent in schistosomiasis: 14,15-epoxygeranylgeraniol., Science, 157, 950, 10.1126\u002Fscience.157.3791.950",{"doi":400},"10.1126\u002Fscience.157.3791.950",{"id":24,"text":402,"url":24,"identifiers":403},"NETO J.J, 1976, Contribuição ao Estudo Farmacognóstico dos frutos de Pterodon pubescens Bentham: Parte III- Identificação cromatográfica em fase gasosa, química e ação microbiológica do óleo do fruto, Rev. Fac. Farm. Odontol., Araraquara, 10, 317",{},{"id":24,"text":405,"url":24,"identifiers":406},"NUNAN E.A, 1982, Furane diterpenes with anti- and pro-inflammatory activity, Rev. Bras. Pesq. Med. Biol, 15, 450",{},{"id":24,"text":408,"url":24,"identifiers":409},"OLIVEIRA D.M.T, 2005, Anatomy and Ontogeny of Pterodon emarginatus (FABACEAE: FABOIDEAE) Seed, Braz. J. Biol., 65, 483, 10.1590\u002FS1519-69842005000300014",{"doi":410},"10.1590\u002FS1519-69842005000300014",{"id":24,"text":412,"url":24,"identifiers":413},"PIMENTA A.T.A, 2006, Estudo fitoquímico e avaliação da atividade larvicida de Pterodon polygalaeflorus Benth (Leguminosae) sobre Aedes aegypti, Rev. Bras. Farm, 16, 501, 10.1590\u002FS0102-695X2006000400011",{"doi":414},"10.1590\u002FS0102-695X2006000400011",{"id":24,"text":416,"url":24,"identifiers":417},"SABINO K.C, 1999, vitro and in vivo toxicological study of the Pterodon pubescens seed oil, Toxicol. Lett, 108, 27, 10.1016\u002FS0378-4274(99)00110-1",{"doi":418},"10.1016\u002FS0378-4274(99)00110-1",{"id":24,"text":420,"url":24,"identifiers":421},"SABINO K.C, 1999, Successful treatment of collagen-induced arthritis in mice with a hydroalcohol extract of seeds of Pterodon pubescens, Phytother. Res, 13, 613, 10.1002\u002F(SICI)1099-1573(199911)13:7\u003C613::AID-PTR503>3.0.CO;2-D",{"doi":422},"10.1002\u002F(SICI)1099-1573(199911)13:7\u003C613::AID-PTR503>3.0.CO;2-D",{"id":24,"text":424,"url":24,"identifiers":425},"SANTOS FILHO D, 1969, Prophylaxis of Schistosoma by the fruit oil of Pterodon pubescens Benth. [Profilaxia de esquistossomose pelo óleo de Pterodon pubescens Benth: Dois novos diterpenos]., Bol. Fac. Farm. Odontol. Ribeirão Preto, 6, 142",{},{"id":24,"text":427,"url":24,"identifiers":428},"SILVA M.C, 2004, Acute and topic anti-edematogenic fractions isolated from the seeds of Pterodon pubescens, J. Pharm. Pharmacol, 56, 135, 10.1211\u002F0022357022485",{"doi":429},"10.1211\u002F0022357022485",{"id":24,"text":431,"url":24,"identifiers":432},"SILVA D.P, 2007, . Identification of an α-Amylase Inhibitor from Pterodon pubescens with Ability To Inhibit Cowpea Weevil Digestive Enzymes., J. Agric. Food Chem., 55, 4382, 10.1021\u002Fjf0637628",{"doi":433},"10.1021\u002Fjf0637628",{"id":24,"text":435,"url":24,"identifiers":436},"SPINDOLA H.M, 2009, Furanoditerpenes from Pterodon pubescens Benth with selective in vitro anticancer activity for prostate cell line, J.Braz.Chem. Soc., 20, 569, 10.1590\u002FS0103-50532009000300024",{"doi":437},"10.1590\u002FS0103-50532009000300024",{"id":24,"text":439,"url":24,"identifiers":440},"SUÁREZ G.R, 1980, Depósito de taninos en la testa de Amaranthus hypochondriacus L. (alegria), Agrociencia, 42, 35",{},{"id":24,"text":442,"url":24,"identifiers":443},"TORRENEGRA R, 1989, Homoormosanine-Type Alkaloids from Bowdichia Virgiloides, Phytochemistry, 28, 2219, 10.1016\u002FS0031-9422(00)97953-6",{"doi":444},"10.1016\u002FS0031-9422(00)97953-6",{"id":24,"text":446,"url":24,"identifiers":447},"VIEIRA C.R, 2008, Antiproliferative activity of Pterodon pubescens Benth. seed oil and its active principle on human melanoma cells, Phytomedicine, 15, 528, 10.1016\u002Fj.phymed.2007.08.003",{"doi":448},"10.1016\u002Fj.phymed.2007.08.003",false,{"id":451,"createTime":452,"updateTime":452,"relativeEntities":453,"slug":454,"properties":455,"entityType":134,"verifyStatus":135,"verifyTime":452,"verifyNote":137,"syncStatus":23,"languages":467,"translateLanguages":24,"viewCount":25,"primaryUrl":468,"fullTextUrl":24,"authors":469,"publicationType":201,"publisherRelationship":507,"citationCount":545,"citationInfo":546,"publishDate":551,"publishYear":552,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":553,"isForceReanalyzing":449},"a6fd1e58-7a19-4f91-9e08-3b8497c2eba5","2025-01-02T18:44:21.600+00:00",[],"Study-of-thermal-behavior-of-phytic-acid",{"mag":456,"keywords":458,"openalex":459,"abstract":461,"title":463,"doi":465},{"VOID":457},"2075458867",{},{"VOID":460},"W2075458867",{"EN":462},"\u003Cjats:p>Phytic acid is a natural compound widely used as depigmenting agent in galenic cosmetic emulsions. However, we have observed experimentally that phytic acid, when heated to 150 ºC for around one hour, shows evidence of thermal decomposition. Few studies investigating this substance alone with regard to its stability are available in the literature. This fact prompted the present study to characterize this species and its thermal behavior using thermal analysis (TG\u002FDTG and DSC) and to associate the results of these techniques with those obtained by elemental analysis (EA) and absorption spectroscopy in the infrared region. The TG\u002FDTG and DSC curves allowed evaluation of the thermal behavior of the sample of phytic acid and enabled use of the non-isothermal thermogravimetric method to study the kinetics of the three main mass-loss events: dehydration I, dehydration II and thermal decomposition. The combination of infrared absorption spectroscopy and elemental analysis techniques allowed evaluation of the intermediate products of the thermal decomposition of phytic acid. The infrared spectra of samples taken during the heating process revealed a reduction in the intensity of the absorption band related to O-H stretching as a result of the dehydration process. Furthermore, elemental analysis results showed an increase in the carbon content and a decrease in the hydrogen content at temperatures of 95, 150, 263 and 380 °C. Visually, darkening of the material was observed at 150 °C, indicating that the thermal decomposition of the material started at this temperature. At a temperature of 380 °C, thermal decomposition progressed, leading to a decrease in carbon and hydrogen. The results of thermogravimetry coupled with those of elemental analysis allow us to conclude that there was agreement between the percentages of phytic acid found in aqueous solution. The kinetic study by the non-isothermal thermogravimetric method showed that the dehydration process occurred in two stages. Dehydration step I promoted a process of vaporization of water (reaction order of zero), whereas dehydration step II showed an order of reaction equal to five. This change in reaction order was attributed to loss of chemically bonded water molecules of phytic acid or to the presence of volatile substances. Finally, the thermal decomposition step revealed an order of reaction equal to one. It was not possible to perform the kinetic study for other stages of mass loss.\u003C\u002Fjats:p>",{"EN":464},"Study of thermal behavior of phytic acid",{"VOID":466},"10.1590\u002Fs1984-82502013000200009",[139],"http:\u002F\u002Fwww.scielo.br\u002Fscielo.php?script=sci_arttext&pid=S1984-82502013000200009&lng=en&tlng=en",[470,490],{"id":471,"sortIndex":25,"researcher":24,"roles":472,"affiliations":473,"properties":485},"c4ac2541-022b-408d-a413-f041da5cca13",[],[474],{"id":475,"sortIndex":25,"affiliation":476,"properties":24},"be452601-634c-436b-a957-6df9367ee881",{"id":477,"createTime":478,"updateTime":479,"relativeEntities":480,"slug":481,"properties":482,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"7de3ea89-5c94-45d1-b803-bca425efb71b","2023-12-26T08:00:48.139+00:00","2025-02-08T05:37:06.293+00:00",[],"University-of-S%C3%A3o-Paulo",{"title":483},{"VI":484},"University of São Paulo",{"openalex":486,"title":488},{"VOID":487},"A5063408216",{"EN":489},"André Luis Máximo Daneluti",{"id":491,"sortIndex":104,"researcher":24,"roles":492,"affiliations":493,"properties":500},"917917f7-f26e-4bad-9a37-258334d19868",[],[494],{"id":495,"sortIndex":25,"affiliation":496,"properties":24},"fcb9c8c7-478c-448f-8371-05f8b432da89",{"id":477,"createTime":478,"updateTime":479,"relativeEntities":497,"slug":481,"properties":498,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":499},{"VI":484},{"openalex":501,"orcid":503,"title":505},{"VOID":502},"A5025506082",{"VOID":504},"https:\u002F\u002Forcid.org\u002F0000-0002-1793-7735",{"EN":506},"Jivaldo do Rosário Matos",{"url":24,"publisher":508,"properties":538},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":509,"slug":10,"properties":510,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":516,"manageAffiliations":517,"indexDatabases":518,"url":96,"thumbnailPath":24,"statistic":533,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":511,"issn":512,"introduce":513,"eissn":514,"title":515},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[519,526],{"id":78,"indexDatabase":520,"url":91,"indexYears":92,"academicFieldIds":525,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":521,"label":522,"description":523,"key":88,"publicationTags":524,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"id":59,"indexDatabase":527,"url":74,"indexYears":24,"academicFieldIds":532,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":528,"label":529,"description":530,"key":70,"publicationTags":531,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"impactFactor":25,"impactFactorByYear":534,"i10Index":100,"i10IndexLast5Year":25,"totalPublication":101,"totalPublicationByYear":535,"totalCitation":105,"totalCitationByYear":536,"totalCitationPerPublication":110,"totalCitationPerPublicationByYear":537,"hindexLast5Year":100,"hindex":100},{"2012":99},{"2010":103,"2011":104,"2013":104},{"2010":107,"2011":108,"2013":109},{"2010":112,"2011":108,"2013":109},{"volume":539,"pages":541,"issue":543},{"VOID":540},"49",{"VOID":542},"275-283",{"VOID":544},"2",91,{"total":545,"publishYear":24,"statisticByYear":547},{"2014":100,"2015":243,"2016":243,"2017":548,"2018":244,"2019":101,"2020":100,"2021":108,"2022":108,"2023":549,"2024":550},8,21,15,"2013-06-01",2013,[554,558,561,565,569,573,577,581,585,589,593,597,600,604,608,612,616,620,624,628,632],{"id":24,"text":555,"url":24,"identifiers":556},"ARAÚJO A.A.S., 2003, Thermal analysis of the antiretroviral Zidovudine (AZT) and evaluation of the compatibility with adjuvant used in solid dosage forms, Int. J. Pharm., 206, 303, 10.1016\u002FS0378-5173(03)00288-6",{"doi":557},"10.1016\u002FS0378-5173(03)00288-6",{"id":24,"text":559,"url":24,"identifiers":560},"AROCHA J.R., 2003, Nuevas opciones en el tratamiento del melasma, Dermat. Venez., 41, 11",{},{"id":24,"text":562,"url":24,"identifiers":563},"CARLI D.L., 2006, Estudo da estabilidade do ácido fítico e o íon Ni(II), Cienc. Tecnol. Aliment., 26, 19, 10.1590\u002FS0101-20612006000100004",{"doi":564},"10.1590\u002FS0101-20612006000100004",{"id":24,"text":566,"url":24,"identifiers":567},"CIDES L.C.S., 2006, Thermal behaviour, compatibility study and decompositions kinetics of glimepiride under isothermal and non-isothermal conditions, J. Therm. Anal. Calorim., 84, 441, 10.1007\u002Fs10973-005-7131-8",{"doi":568},"10.1007\u002Fs10973-005-7131-8",{"id":24,"text":570,"url":24,"identifiers":571},"COSGROVE D.J., 1963, The isolation of myoinositolpentaphosphates from hydrolysates of phytic acid, Biochem. J., 89, 172, 10.1042\u002Fbj0890172",{"doi":572},"10.1042\u002Fbj0890172",{"id":24,"text":574,"url":24,"identifiers":575},"EMPSON K.L., 1991, Phytic acid as a food antioxidant, J. Food Sci., 56, 560, 10.1111\u002Fj.1365-2621.1991.tb05324.x",{"doi":576},"10.1111\u002Fj.1365-2621.1991.tb05324.x",{"id":24,"text":578,"url":24,"identifiers":579},"FELIX F.S., 2009, Thermal behavior study and decomposition kinetics of Salbutamol under isothermal and non-isothermal conditions, J. Therm. Anal. Calorim., 95, 877, 10.1007\u002Fs10973-007-8188-3",{"doi":580},"10.1007\u002Fs10973-007-8188-3",{"id":24,"text":582,"url":24,"identifiers":583},"GIRON D., 1986, Applications of thermal analysis in the pharmaceutical industry, J. Pharm. Biomed. Anal., 4, 755, 10.1016\u002F0731-7085(86)80086-3",{"doi":584},"10.1016\u002F0731-7085(86)80086-3",{"id":24,"text":586,"url":24,"identifiers":587},"GIRON D., 2002, Applications of thermal analysis and coupled techniques in pharmaceutical industry, J. Therm. Anal. Calorim., 68, 335, 10.1023\u002FA:1016015113795",{"doi":588},"10.1023\u002FA:1016015113795",{"id":24,"text":590,"url":24,"identifiers":591},"LEE B.J., 1995, Phytic acid protective effect against beef round muscle lipid peroxidation, J. Food Sci., 60, 241, 10.1111\u002Fj.1365-2621.1995.tb05646.x",{"doi":592},"10.1111\u002Fj.1365-2621.1995.tb05646.x",{"id":24,"text":594,"url":24,"identifiers":595},"MAGA J.A., 1982, Phytate: its chemistry, occurrence, food interactions, nutritional significance, and methods of analysis, J. Agric. Food Chem., 30, 1, 10.1021\u002Fjf00109a001",{"doi":596},"10.1021\u002Fjf00109a001",{"id":24,"text":598,"url":24,"identifiers":599},"MATOS J.R., 2009, Análise térmica aplicada a fármacos e medicamentos, 1, 32",{},{"id":24,"text":601,"url":24,"identifiers":602},"OZAWA T., 1965, A new method of analyzing thermogravimetric data, Bull. Chem. Soc. Jpn., 38, 1881, 10.1246\u002Fbcsj.38.1881",{"doi":603},"10.1246\u002Fbcsj.38.1881",{"id":24,"text":605,"url":24,"identifiers":606},"OZAWA T., 2000, Thermal analysis: review and prospect, Thermochim. Acta, 355, 35, 10.1016\u002FS0040-6031(00)00435-4",{"doi":607},"10.1016\u002FS0040-6031(00)00435-4",{"id":24,"text":609,"url":24,"identifiers":610},"QUIRRENBACH H.R., 2009, Comportamento do ácido fítico na presença de Fe(II) e Fe(III, Cienc. Tecnol. Aliment., 29, 24, 10.1590\u002FS0101-20612009000100005",{"doi":611},"10.1590\u002FS0101-20612009000100005",{"id":24,"text":613,"url":24,"identifiers":614},"RAVINDRAN V., 1994, Total and phytate phosphorus contents of various foods and feedstuffs of plant origin, Food Chem., 50, 133, 10.1016\u002F0308-8146(94)90109-0",{"doi":615},"10.1016\u002F0308-8146(94)90109-0",{"id":24,"text":617,"url":24,"identifiers":618},"RODANTE F., 2002, Kinetic analysis of single or multi-step decomposition processes, J. Therm. Anal. Calorim., 68, 689, 10.1023\u002FA:1016024810586",{"doi":619},"10.1023\u002FA:1016024810586",{"id":24,"text":621,"url":24,"identifiers":622},"SALVIO NETO H., 2009, Thermal analysis and compatibility studies of predinicarbate with excipients used in semi solid pharmaceutical form, J. Therm. Anal. Calorim., 97, 367, 10.1007\u002Fs10973-009-0234-x",{"doi":623},"10.1007\u002Fs10973-009-0234-x",{"id":24,"text":625,"url":24,"identifiers":626},"TOMASSETTI M., 2005, Thermal analysis study of interaction between acetoaminophen and excipients in solid dosage forms and in some binary mixtures, J. Pharm.Biomed. Anal., 37, 949, 10.1016\u002Fj.jpba.2004.10.008",{"doi":627},"10.1016\u002Fj.jpba.2004.10.008",{"id":24,"text":629,"url":24,"identifiers":630},"TORRE M., 1991, Effects of dietary fiber and phytic acid on mineral availability, CRC Crit. Rev. Food Sci. Nutr., 1, 1, 10.1080\u002F10408399109527539",{"doi":631},"10.1080\u002F10408399109527539",{"id":24,"text":633,"url":24,"identifiers":634},"URBANO G., 2000, The role of phytic acid in legumes: antinutrient or beneficial function?, J. Physiol. Biochem., 56, 283, 10.1007\u002FBF03179796",{"doi":635},"10.1007\u002FBF03179796",{"id":637,"createTime":638,"updateTime":638,"relativeEntities":639,"slug":640,"properties":641,"entityType":134,"verifyStatus":135,"verifyTime":652,"verifyNote":137,"syncStatus":23,"languages":653,"translateLanguages":24,"viewCount":25,"primaryUrl":654,"fullTextUrl":24,"authors":655,"publicationType":201,"publisherRelationship":733,"citationCount":103,"citationInfo":769,"publishDate":24,"publishYear":24,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":771,"isForceReanalyzing":449},"6215b4da-da25-431f-9a46-e8d4c10499cd","2024-10-12T17:05:49.177+00:00",[],"Aggravation-of-cyclophosphamide-induced-reproductive-toxicity-in-mice-by-aqueous-extract-of-Aegle-marmelos-L-",{"mag":642,"keywords":644,"openalex":645,"abstract":647,"title":648,"doi":650},{"VOID":643},"2765698935",{},{"VOID":646},"W2765698935",{},{"EN":649},"Aggravation of cyclophosphamide-induced reproductive toxicity in mice by aqueous extract of Aegle marmelos (L.)",{"VOID":651},"10.1590\u002Fs2175-97902017000300177","2024-10-12T17:05:49.176+00:00",[139],"http:\u002F\u002Fwww.scielo.br\u002Fscielo.php?script=sci_arttext&pid=S1984-82502017000300614&lng=en&tlng=en",[656,677,699,716],{"id":657,"sortIndex":104,"researcher":24,"roles":658,"affiliations":659,"properties":670},"6e44f9eb-7640-4d82-8591-25500b4509c4",[],[660],{"id":661,"sortIndex":25,"affiliation":662,"properties":24},"2687327e-2ade-4f70-bf70-8b871385da5e",{"id":663,"createTime":664,"updateTime":664,"relativeEntities":665,"slug":666,"properties":667,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"7f519e8b-6cc8-4c05-9665-c1f2a6e164f0","2024-10-12T17:05:49.210+00:00",[],"Department-of-Botany-MMV-Banaras-Hindu-University-Varanasi-U-P-India",{"title":668},{"EN":669},"Department of Botany, MMV, Banaras Hindu University, Varanasi, U.P, India",{"openalex":671,"orcid":673,"title":675},{"VOID":672},"A5038362111",{"VOID":674},"https:\u002F\u002Forcid.org\u002F0000-0003-1311-5854",{"EN":676},"Awadhesh Kumar Mishra",{"id":678,"sortIndex":25,"researcher":24,"roles":679,"affiliations":680,"properties":692},"92575397-c45e-4637-ba45-2ce3d79f2593",[],[681],{"id":682,"sortIndex":25,"affiliation":683,"properties":24},"41bc9794-1b2c-4384-998f-640ab20bbd1f",{"id":684,"createTime":685,"updateTime":686,"relativeEntities":687,"slug":688,"properties":689,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"080d3933-b88e-456b-bf67-beb64d31017c","2024-10-12T17:05:49.193+00:00","2025-06-11T21:03:57.179+00:00",[],"Department-of-Zoology-MMV-Banaras-Hindu-University-Varanasi-U-P-India",{"title":690},{"EN":691},"Department of Zoology, MMV, Banaras Hindu University, Varanasi, U.P, India",{"openalex":693,"orcid":695,"title":697},{"VOID":694},"A5088991545",{"VOID":696},"https:\u002F\u002Forcid.org\u002F0000-0002-6116-8603",{"EN":698},"Sangita Singh",{"id":700,"sortIndex":243,"researcher":24,"roles":701,"affiliations":702,"properties":709},"abd569ff-dbb6-4c4d-a173-37fe742248f8",[],[703],{"id":704,"sortIndex":25,"affiliation":705,"properties":24},"1aec02cd-b4bc-4ea6-8764-140dc2c66061",{"id":663,"createTime":664,"updateTime":664,"relativeEntities":706,"slug":666,"properties":707,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":708},{"EN":669},{"openalex":710,"orcid":712,"title":714},{"VOID":711},"A5065766420",{"VOID":713},"https:\u002F\u002Forcid.org\u002F0000-0002-8951-9057",{"EN":715},"Kavindra Nath Tiwari",{"id":717,"sortIndex":103,"researcher":24,"roles":718,"affiliations":719,"properties":726},"cb0ed744-23f2-47ab-9ef2-4cbca3fd1c9c",[],[720],{"id":721,"sortIndex":25,"affiliation":722,"properties":24},"c10c7d3b-14a2-42fa-ab30-3f976a4dacf5",{"id":684,"createTime":685,"updateTime":686,"relativeEntities":723,"slug":688,"properties":724,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":725},{"EN":691},{"openalex":727,"orcid":729,"title":731},{"VOID":728},"A5069184974",{"VOID":730},"https:\u002F\u002Forcid.org\u002F0000-0002-2509-6438",{"EN":732},"Swaran Lata",{"url":24,"publisher":734,"properties":764},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":735,"slug":10,"properties":736,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":742,"manageAffiliations":743,"indexDatabases":744,"url":96,"thumbnailPath":24,"statistic":759,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":737,"issn":738,"introduce":739,"eissn":740,"title":741},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[745,752],{"id":78,"indexDatabase":746,"url":91,"indexYears":92,"academicFieldIds":751,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":747,"label":748,"description":749,"key":88,"publicationTags":750,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"id":59,"indexDatabase":753,"url":74,"indexYears":24,"academicFieldIds":758,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":754,"label":755,"description":756,"key":70,"publicationTags":757,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"impactFactor":25,"impactFactorByYear":760,"i10Index":100,"i10IndexLast5Year":25,"totalPublication":101,"totalPublicationByYear":761,"totalCitation":105,"totalCitationByYear":762,"totalCitationPerPublication":110,"totalCitationPerPublicationByYear":763,"hindexLast5Year":100,"hindex":100},{"2012":99},{"2010":103,"2011":104,"2013":104},{"2010":107,"2011":108,"2013":109},{"2010":112,"2011":108,"2013":109},{"volume":765,"issue":767},{"VOID":766},"53",{"VOID":768},"3",{"total":103,"publishYear":24,"statisticByYear":770},{"2021":104,"2023":104},[772,775,779,783,787,791,794,798,801,804,808,811,814,817,821,824,828,832,836,840,844,848,852,855,858,861,865,869,872,875,879,882,885,889,893,896,900],{"id":24,"text":773,"url":24,"identifiers":774},"Anitha M, 2013, Evaluation of anti-fertility activity of ethanol extract of Cynoglossum zeylanicum (vehl ex hornem) thumb ex lehm (boraginaceae) whole plant on male albino rats, J Curr Chem Pharma Sci, 3, 135",{},{"id":24,"text":776,"url":24,"identifiers":777},"Ansari AS, 1998, Long-term sequelae of tolnidamine on male reproduction and general body metabolism in rabbits, Contraception, 57, 271, 10.1016\u002FS0010-7824(98)00031-6",{"doi":778},"10.1016\u002FS0010-7824(98)00031-6",{"id":24,"text":780,"url":24,"identifiers":781},"Arul V, 2005, Studies on the anti-inflammatory, antipyretic and analgesic properties of leaves of Aegle marmelos Corr, J Ethnopharmacol, 96, 159, 10.1016\u002Fj.jep.2004.09.013",{"doi":782},"10.1016\u002Fj.jep.2004.09.013",{"id":24,"text":784,"url":24,"identifiers":785},"Banerji J, 2000, The reversible antifertility effect of Piper beetle Linn on Swiss albino male mice, Contraception, 62, 271, 10.1016\u002FS0010-7824(00)00177-3",{"doi":786},"10.1016\u002FS0010-7824(00)00177-3",{"id":24,"text":788,"url":24,"identifiers":789},"Cao Y, 2017, The effects of L-carnitine against cyclophosphamide-induced injuries in mouse testis, Basic Clin Pharmacol Toxicol, 120, 152, 10.1111\u002Fbcpt.12679",{"doi":790},"10.1111\u002Fbcpt.12679",{"id":24,"text":792,"url":24,"identifiers":793},"Chanda R, 2008, Phytochemical and pharmacological activity of Aegle marmelos as a potential medicinal plant an overview, The Int J Pharm, 6, 3",{},{"id":24,"text":795,"url":24,"identifiers":796},"Comish PB, 2014, Fetal cyclophosphamide exposure induces testicular cancer and reduced spermatogenesis and ovarian follicle numbers in mice, PLoS One, 9, 10.1371\u002Fjournal.pone.0093311",{"doi":797},"10.1371\u002Fjournal.pone.0093311",{"id":24,"text":799,"url":24,"identifiers":800},"Cooper TG, 1992, The epididymis as a site of contraceptive attack, 419",{},{"id":24,"text":802,"url":24,"identifiers":803},"D'Souza UJA, 2001, Introduction of seminiferous tubular atrophy by single dose of 5- fluorouracil (5-FU) in Wistar rats, Indian J Physiol Pharmacol, 45, 87",{},{"id":24,"text":805,"url":24,"identifiers":806},"Daniel EH, 2011, A common mutation in the defensin DEFB126 causes impaired sperm function and sub fertility, Euro Urol, 60, 1304, 10.1016\u002Fj.eururo.2011.08.067",{"doi":807},"10.1016\u002Fj.eururo.2011.08.067",{"id":24,"text":809,"url":24,"identifiers":810},"Das UB, 2002, Protective effect of ascorbic acid on cyclophosphamide-induced testicular gametogenic and androgenic disorders in male rats, Asian J Androl, 4, 201",{},{"id":24,"text":812,"url":24,"identifiers":813},"Das UK, 2009, Antigonadal effect induced by hydro-methanolic extract of leaf of Aelgle mermelos in male rat effect of hCG co-administration, J Med Plants Res, 3, 728",{},{"id":24,"text":815,"url":24,"identifiers":816},"Dollery C, 1999",{},{"id":24,"text":818,"url":24,"identifiers":819},"El-Naggar SA, 2015, Ameliorative effect of propolis against cyclophosphamide induced toxicity in mice, Pharm Biol, 53, 235, 10.3109\u002F13880209.2014.914230",{"doi":820},"10.3109\u002F13880209.2014.914230",{"id":24,"text":822,"url":24,"identifiers":823},"Enders G, 1997, Clinical approaches to male infertility with a case report of possible nifedipine-induced sperm dysfunction, J Am Board Fam Pract, 10, 131",{},{"id":24,"text":825,"url":24,"identifiers":826},"Faremi TY, 2008, Hepatoprotective potentials of Phyllanthus amarus against ethanol-induced oxidative stress in rats, Food Chem Toxicol, 46, 2658, 10.1016\u002Fj.fct.2008.04.022",{"doi":827},"10.1016\u002Fj.fct.2008.04.022",{"id":24,"text":829,"url":24,"identifiers":830},"Higuchi H, 2001, Application of computer-assisted sperm analysis system to elucidate lack of effects of cyclophosphamide on rat epididymal sperm motion, J Toxicol Sci, 26, 75, 10.2131\u002Fjts.26.75",{"doi":831},"10.2131\u002Fjts.26.75",{"id":24,"text":833,"url":24,"identifiers":834},"Howell S, 1998, Gonadal damage from chemotherapy and radiotherapy, Endocrinol Metab Clin North Am, 27, 927, 10.1016\u002FS0889-8529(05)70048-7",{"doi":835},"10.1016\u002FS0889-8529(05)70048-7",{"id":24,"text":837,"url":24,"identifiers":838},"Jagetia GC, 2005, Aegle marmelos (L ) Correa inhibit proliferation of transplanted Earlich ascites carcinoma in mice, Biol Pharm Bull, 28, 58, 10.1248\u002Fbpb.28.58",{"doi":839},"10.1248\u002Fbpb.28.58",{"id":24,"text":841,"url":24,"identifiers":842},"Jalali AS, 2012, Achillea millefoliumin florescence aqueous extract ameliorates cyclophosphamide-induced toxicity in rat testis stereological evidences, Chin J Nat Med, 10, 247, 10.3724\u002FSP.J.1009.2012.00247",{"doi":843},"10.3724\u002FSP.J.1009.2012.00247",{"id":24,"text":845,"url":24,"identifiers":846},"Kawakami E, 2007, Superoxide dismutase and catalase activities in the seminal plasma of normospermic and asthenozoospermic beagles, J Vet Med Sci, 69, 133, 10.1292\u002Fjvms.69.133",{"doi":847},"10.1292\u002Fjvms.69.133",{"id":24,"text":849,"url":24,"identifiers":850},"Kenney LB, 2001, High risk of infertility and long term gonadal damage in males treated with high dose cyclophosphamide for sarcoma during childhood, Cancer, 91, 613, 10.1002\u002F1097-0142(20010201)91:3\u003C613::AID-CNCR1042>3.0.CO;2-R",{"doi":851},"10.1002\u002F1097-0142(20010201)91:3\u003C613::AID-CNCR1042>3.0.CO;2-R",{"id":24,"text":853,"url":24,"identifiers":854},"Kuncha J, 2011, Hepatoprotective effect of Aegle marmelos (L ) Corr. leaf powder (crude) against carbon tetrachloride induced hepatic damage in albino rats, J Pharm Sci Res, 3, 1360",{},{"id":24,"text":856,"url":24,"identifiers":857},"Lohiya NK, 1992, Antifertility investigations on the crude chloroform extract of Carica papaya Linn, seeds in male albino rats, Indian J Exp Biol, 30, 1051",{},{"id":24,"text":859,"url":24,"identifiers":860},"Maity P, 2009, Biological activities of crude extracts and chemical constituents of Bael, Aegle marmelos (L ), Corr Indian J Exp Biol, 47, 849",{},{"id":24,"text":862,"url":24,"identifiers":863},"Maremanda KP, 2014, Zinc protects cyclophosphamide-induced testicular damage in rat involvement of metallothionein, tesmin and Nrf2, Biochem Bioph Res Commun, 445, 591, 10.1016\u002Fj.bbrc.2014.02.055",{"doi":864},"10.1016\u002Fj.bbrc.2014.02.055",{"id":24,"text":866,"url":24,"identifiers":867},"Narender T, 2007, Antihyperglycemic and antidyslipidemic agent from Aegle marmelos, Bioorg Med Chem Lett, 17, 1808, 10.1016\u002Fj.bmcl.2006.12.037",{"doi":868},"10.1016\u002Fj.bmcl.2006.12.037",{"id":24,"text":870,"url":24,"identifiers":871},"Nugroho AE, 2011, Effects of marmin, a compound isolated from Aegle marmelos Correa, on contraction of the guinea pig-isolated trachea, Pak J Pharma Sci, 24, 427",{},{"id":24,"text":873,"url":24,"identifiers":874},"Pushpendra KP, 2012, Aegle marmelos a review on its medicinal properties, Int J Pharm Phytopharmacol Res, 1, 332",{},{"id":24,"text":876,"url":24,"identifiers":877},"Sharma N, 2002, Assessment of reversible contraceptive efficacy of methanol extract of Mentha arvensis L leaves in male albino mice, J Ethnopharmacol, 80, 9, 10.1016\u002FS0378-8741(01)00364-6",{"doi":878},"10.1016\u002FS0378-8741(01)00364-6",{"id":24,"text":880,"url":24,"identifiers":881},"Singh KP, 1981, Determination of antiprotozoal activity in chronic dysentery from the pulp of Aegle marmelos, Sanch Ayu, 8, 34",{},{"id":24,"text":883,"url":24,"identifiers":884},"Singh S, 2014, Aegle marmelos leaves protect liver against toxic effects of cyclophosphamide in mice, New York Sci J, 7, 43",{},{"id":24,"text":886,"url":24,"identifiers":887},"Singh SK, 2003, Antispermatogenic and antifertility effects of 20, 25-diazacholesterol dihydrochloride in mice, Repro Toxicol, 17, 37, 10.1016\u002FS0890-6238(02)00075-8",{"doi":888},"10.1016\u002FS0890-6238(02)00075-8",{"id":24,"text":890,"url":24,"identifiers":891},"Trasler JM, 1986, Chronic low dose cyclophosphamide treatment of adult male rats effect on fertility, pregnancy outcome and progeny, Biol Reprod, 34, 275, 10.1095\u002Fbiolreprod34.2.275",{"doi":892},"10.1095\u002Fbiolreprod34.2.275",{"id":24,"text":894,"url":24,"identifiers":895},"2010, 5",{},{"id":24,"text":897,"url":24,"identifiers":898},"Yuan D, 2014, Protective Effects of total flavonoids from Epimedium on the male mouse reproductive system against cyclophosphamide-induced oxidative injury by up-regulating the expressions of SOD3 and GPX1, Phytother Res, 28, 88, 10.1002\u002Fptr.4956",{"doi":899},"10.1002\u002Fptr.4956",{"id":24,"text":901,"url":24,"identifiers":902},"Zalata AA, 1998, White blood cells cause oxidative damage to the fatty acid composition of phospholipids of human spermatozoa, Int J Androl, 21, 154, 10.1111\u002Fj.1365-2605.1998.00112.x",{"doi":903},"10.1111\u002Fj.1365-2605.1998.00112.x",{"id":905,"createTime":906,"updateTime":906,"relativeEntities":907,"slug":908,"properties":909,"entityType":134,"verifyStatus":135,"verifyTime":906,"verifyNote":137,"syncStatus":23,"languages":921,"translateLanguages":24,"viewCount":25,"primaryUrl":922,"fullTextUrl":24,"authors":923,"publicationType":201,"publisherRelationship":1027,"citationCount":1063,"citationInfo":1064,"publishDate":1068,"publishYear":246,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1069,"isForceReanalyzing":449},"c4347d1c-8361-496f-b0ad-8ceb796284bf","2025-01-24T15:23:31.610+00:00",[],"Thermal-behavior-and-decomposition-kinetics-of-rifampicin-polymorphs-under-isothermal-and-non-isothermal-conditions",{"mag":910,"keywords":912,"openalex":913,"abstract":915,"title":917,"doi":919},{"VOID":911},"2044754444",{},{"VOID":914},"W2044754444",{"EN":916},"\u003Cjats:p>The thermal behavior of two polymorphic forms of rifampicin was studied by DSC and TG\u002FDTG. The thermoanalytical results clearly showed the differences between the two crystalline forms. Polymorph I was the most thermally stable form, the DSC curve showed no fusion for this species and the thermal decomposition process occurred around 245 ºC. The DSC curve of polymorph II showed two consecutive events, an endothermic event (Tpeak = 193.9 ºC) and one exothermic event (Tpeak = 209.4 ºC), due to a melting process followed by recrystallization, which was attributed to the conversion of form II to form I. Isothermal and non-isothermal thermogravimetric methods were used to determine the kinetic parameters of the thermal decomposition process. For non-isothermal experiments, the activation energy (Ea) was derived from the plot of Log β vs 1\u002FT, yielding values for polymorph form I and II of 154 and 123 kJ mol-1, respectively. In the isothermal experiments, the Ea was obtained from the plot of lnt vs 1\u002FT at a constant conversion level. The mean values found for form I and form II were 137 and 144 kJ mol-1, respectively.\u003C\u002Fjats:p>",{"EN":918},"Thermal behavior and decomposition kinetics of rifampicin polymorphs under isothermal and non-isothermal conditions",{"VOID":920},"10.1590\u002Fs1984-82502010000200022",[139],"http:\u002F\u002Fwww.scielo.br\u002Fscielo.php?script=sci_arttext&pid=S1984-82502010000200022&lng=en&tlng=en",[924,938,959,974,991,1008],{"id":925,"sortIndex":101,"researcher":24,"roles":926,"affiliations":927,"properties":934},"3836813a-7825-4291-9098-08a8699160c9",[],[928],{"id":929,"sortIndex":25,"affiliation":930,"properties":24},"fe780a62-8449-4205-b8dd-2decf701ea65",{"id":477,"createTime":478,"updateTime":479,"relativeEntities":931,"slug":481,"properties":932,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":933},{"VI":484},{"openalex":935,"orcid":936,"title":937},{"VOID":502},{"VOID":504},{"EN":506},{"id":939,"sortIndex":100,"researcher":24,"roles":940,"affiliations":941,"properties":952},"1029e7cd-8186-445f-914b-c479f24cf639",[],[942],{"id":943,"sortIndex":25,"affiliation":944,"properties":24},"86933b2a-d9be-4c2e-9f57-84e801436cc6",{"id":945,"createTime":946,"updateTime":946,"relativeEntities":947,"slug":948,"properties":949,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"f181339f-fbac-40da-9b77-4d49b0e09a5b","2025-01-24T15:23:31.652+00:00",[],"Federal-University-of-Sao-Paulo-TAB-",{"title":950},{"EN":951},"Federal University of Sao Paulo#TAB#",{"openalex":953,"orcid":955,"title":957},{"VOID":954},"A5087781180",{"VOID":956},"https:\u002F\u002Forcid.org\u002F0000-0001-9437-6380",{"EN":958},"Lucildes Pita Mercuri",{"id":960,"sortIndex":103,"researcher":24,"roles":961,"affiliations":962,"properties":969},"20648551-7df7-4dee-8a56-9f1b21d7734b",[],[963],{"id":964,"sortIndex":25,"affiliation":965,"properties":24},"fe93d9f3-886b-433b-95ae-635c505b9325",{"id":477,"createTime":478,"updateTime":479,"relativeEntities":966,"slug":481,"properties":967,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":968},{"VI":484},{"openalex":970,"title":972},{"VOID":971},"A5043918716",{"EN":973},"Luis Carlos Cides da Silva",{"id":975,"sortIndex":243,"researcher":24,"roles":976,"affiliations":977,"properties":984},"83c04369-9af1-4f29-b990-d45911bb9c2b",[],[978],{"id":979,"sortIndex":25,"affiliation":980,"properties":24},"d8d6568e-7c6c-4111-918b-36dd18e66ef0",{"id":477,"createTime":478,"updateTime":479,"relativeEntities":981,"slug":481,"properties":982,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":983},{"VI":484},{"openalex":985,"orcid":987,"title":989},{"VOID":986},"A5060642982",{"VOID":988},"https:\u002F\u002Forcid.org\u002F0000-0001-6156-6890",{"EN":990},"Sı́lvia Storpirtis",{"id":992,"sortIndex":25,"researcher":24,"roles":993,"affiliations":994,"properties":1001},"1d35b312-0e9c-45a4-8db1-974ef5f14743",[],[995],{"id":996,"sortIndex":25,"affiliation":997,"properties":24},"ce220287-702c-4884-b310-02370b87f7d4",{"id":477,"createTime":478,"updateTime":479,"relativeEntities":998,"slug":481,"properties":999,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1000},{"VI":484},{"openalex":1002,"orcid":1004,"title":1006},{"VOID":1003},"A5048582626",{"VOID":1005},"https:\u002F\u002Forcid.org\u002F0000-0001-8958-7263",{"EN":1007},"Ricardo Francisco Alves",{"id":1009,"sortIndex":104,"researcher":24,"roles":1010,"affiliations":1011,"properties":1022},"6ff68693-846a-4326-bfb9-0fe7d93fa5c5",[],[1012],{"id":1013,"sortIndex":25,"affiliation":1014,"properties":24},"be8912bc-65f4-4d16-a14e-c175c5e0d873",{"id":1015,"createTime":1016,"updateTime":1016,"relativeEntities":1017,"slug":1018,"properties":1019,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"ca07c996-8e90-46bd-8b53-8c99a8db00f8","2025-01-24T15:23:31.635+00:00",[],"Oswaldo-Cruz-Faculties",{"title":1020},{"EN":1021},"Oswaldo Cruz Faculties",{"openalex":1023,"title":1025},{"VOID":1024},"A5040468487",{"EN":1026},"Thaís Vitória da Silva Reis",{"url":24,"publisher":1028,"properties":1058},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1029,"slug":10,"properties":1030,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1036,"manageAffiliations":1037,"indexDatabases":1038,"url":96,"thumbnailPath":24,"statistic":1053,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1031,"issn":1032,"introduce":1033,"eissn":1034,"title":1035},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1039,1046],{"id":78,"indexDatabase":1040,"url":91,"indexYears":92,"academicFieldIds":1045,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":1041,"label":1042,"description":1043,"key":88,"publicationTags":1044,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"id":59,"indexDatabase":1047,"url":74,"indexYears":24,"academicFieldIds":1052,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":1048,"label":1049,"description":1050,"key":70,"publicationTags":1051,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"impactFactor":25,"impactFactorByYear":1054,"i10Index":100,"i10IndexLast5Year":25,"totalPublication":101,"totalPublicationByYear":1055,"totalCitation":105,"totalCitationByYear":1056,"totalCitationPerPublication":110,"totalCitationPerPublicationByYear":1057,"hindexLast5Year":100,"hindex":100},{"2012":99},{"2010":103,"2011":104,"2013":104},{"2010":107,"2011":108,"2013":109},{"2010":112,"2011":108,"2013":109},{"volume":1059,"pages":1060,"issue":1062},{"VOID":235},{"VOID":1061},"343-351",{"VOID":544},60,{"total":1063,"publishYear":24,"statisticByYear":1065},{"2012":103,"2013":103,"2014":243,"2015":104,"2016":104,"2017":548,"2018":101,"2020":1066,"2021":100,"2022":244,"2023":1067,"2024":244},9,10,"2010-06-01",[1070,1074,1077,1081,1085,1089,1092,1095,1099,1103,1107,1110,1113,1117,1121,1124,1127,1131,1135,1139,1142,1145],{"id":24,"text":1071,"url":24,"identifiers":1072},"AGRAWAL S, 2004, Solid state characterization of rifampicin samples and its biopharmaceutic relevance, Eur. J. Pharm. Sci, 22, 127, 10.1016\u002Fj.ejps.2004.02.011",{"doi":1073},"10.1016\u002Fj.ejps.2004.02.011",{"id":24,"text":1075,"url":24,"identifiers":1076},"ARAÚJO A. A. S, 2003, Thermal analysis of the antiretroviral zidovudine (AZT) and evaluation of the compatibility with excipients used in solid dosage forms, Int. J. Pharm, 260, 303, 10.1016\u002FS0378-5173(03)00288-6",{"doi":557},{"id":24,"text":1078,"url":24,"identifiers":1079},"BACCHI A, 1998, Comprehensive study on structure-activity relationships of rifamycins: Discussion of molecular and crystal structure and spectroscopic and spectroscopic and thermochemical properties of rifamycin, J. Med. Chem, 41, 2319, 10.1021\u002Fjm970791o",{"doi":1080},"10.1021\u002Fjm970791o",{"id":24,"text":1082,"url":24,"identifiers":1083},"BUJNOWSKI K, 2003, Rifamycin antibiotics-new compounds and synthetic methods: Part 1: Study of the reaction of 3-formylrifamycin SV with primary alkylamines or ammonia, Tetrahedron, 59, 1885, 10.1016\u002FS0040-4020(03)00184-4",{"doi":1084},"10.1016\u002FS0040-4020(03)00184-4",{"id":24,"text":1086,"url":24,"identifiers":1087},"CARVALHO W. S, 2007, Diagnóstico de resistência do Mycobacterium tuberculosis à rifampicina utilizando-se da reação em cadeia da polimerase, Rev. Bras. Ciênc. Farm, 43, 31, 10.1590\u002FS1516-93322007000100004",{"doi":1088},"10.1590\u002FS1516-93322007000100004",{"id":24,"text":1090,"url":24,"identifiers":1091},"CIDES L.C.D, 2006, Thermal behaviour, compatibility study and decomposition kinetics of glimepiride under isothermal and non-isotermal conditions, J. Therm. Anal. Calorim, 84, 441, 10.1007\u002Fs10973-005-7131-8",{"doi":568},{"id":24,"text":1093,"url":24,"identifiers":1094},"FORD J.L, 1989, 108",{},{"id":24,"text":1096,"url":24,"identifiers":1097},"GIRON D, 1998, Contribution of thermal methods and related techniques to the rational development of pharmaceuticals-Part 1, Pharm. Sci. Technol. Today, 1, 191, 10.1016\u002FS1461-5347(98)00046-7",{"doi":1098},"10.1016\u002FS1461-5347(98)00046-7",{"id":24,"text":1100,"url":24,"identifiers":1101},"GIRON D, 1998, Contribution of thermal methods and related techniques to the rational development of pharmaceuticals-Part 2, Pharm. Sci. Technol. Today, 6, 262, 10.1016\u002FS1461-5347(98)00066-2",{"doi":1102},"10.1016\u002FS1461-5347(98)00066-2",{"id":24,"text":1104,"url":24,"identifiers":1105},"HENWOOD S.Q, 2000, Solubility and dissolution properties of generic rifampicin raw materials, Drug Dev. Ind. Pharm, 26, 403, 10.1081\u002FDDC-100101246",{"doi":1106},"10.1081\u002FDDC-100101246",{"id":24,"text":1108,"url":24,"identifiers":1109},"MATOS J.R, 2009, Aspectos gerais relativos ao desenvolvimento farmacotécnico de medicamento: análise térmica aplicada a fármacos e medicamentos, 32",{},{"id":24,"text":1111,"url":24,"identifiers":1112},"OZAWA T, 1965, A new method of analyzing thermogravimetric data, Bull. Chem. Soc. Jpn, 38, 1881, 10.1246\u002Fbcsj.38.1881",{"doi":603},{"id":24,"text":1114,"url":24,"identifiers":1115},"PANCHAGNULA R, 2004, Biopharmaceutic and pharmacokinetics aspects of variable bioavailability of rifampicin, Int. J. Pharm, 271, 1, 10.1016\u002Fj.ijpharm.2003.11.031",{"doi":1116},"10.1016\u002Fj.ijpharm.2003.11.031",{"id":24,"text":1118,"url":24,"identifiers":1119},"PARISE FILHO R, 2004, Thermoanalytical characterization of potentially schistosomicide polymeric derivatives, J. Therm. Anal. Calorim, 75, 487, 10.1023\u002FB:JTAN.0000027137.43662.de",{"doi":1120},"10.1023\u002FB:JTAN.0000027137.43662.de",{"id":24,"text":1122,"url":24,"identifiers":1123},"PELIZZA G, 1977, Polymorphism of rifampicin, Farmaco (Sci), 32, 471",{},{"id":24,"text":1125,"url":24,"identifiers":1126},"ROUQUEROL J, 2007, Developments in nomenclature, 5, 21",{},{"id":24,"text":1128,"url":24,"identifiers":1129},"SALTINI C, 2006, Chemotherapy and diagnosis of tuberculosis, Resp. Med, 100, 2085, 10.1016\u002Fj.rmed.2006.09.015",{"doi":1130},"10.1016\u002Fj.rmed.2006.09.015",{"id":24,"text":1132,"url":24,"identifiers":1133},"SINGH S, 2001, A critical review of probable reasons for the poor\u002Fvariable bioavailability of rifampicin from anti-tubercular fixed-dose combination (FDC) products, and the likely solutions to the problem, Int. J. Pharm, 228, 5, 10.1016\u002FS0378-5173(01)00754-2",{"doi":1134},"10.1016\u002FS0378-5173(01)00754-2",{"id":24,"text":1136,"url":24,"identifiers":1137},"VENKATARAM S, 1995, Differential scanning calorimetry as a quick scanning technique for solid state stability studies, Drug Dev. Ind. Pharm, 21, 847, 10.3109\u002F03639049509026649",{"doi":1138},"10.3109\u002F03639049509026649",{"id":24,"text":1140,"url":24,"identifiers":1141},"2006",{},{"id":24,"text":1143,"url":24,"identifiers":1144},"2007, 5",{},{"id":24,"text":1146,"url":24,"identifiers":1147},"ZHANG Y, 2005, The magic bullets and tuberculosis drug targets, Annu. Rev. Pharmacol. Toxicol, 45, 529, 10.1146\u002Fannurev.pharmtox.45.120403.100120",{"doi":1148},"10.1146\u002Fannurev.pharmtox.45.120403.100120",{"id":1150,"createTime":1151,"updateTime":1151,"relativeEntities":1152,"slug":1153,"properties":1154,"entityType":134,"verifyStatus":135,"verifyTime":1166,"verifyNote":137,"syncStatus":23,"languages":1167,"translateLanguages":24,"viewCount":25,"primaryUrl":1168,"fullTextUrl":24,"authors":1169,"publicationType":201,"publisherRelationship":1208,"citationCount":1245,"citationInfo":1246,"publishDate":1248,"publishYear":1249,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1250,"isForceReanalyzing":449},"7255730e-5d0e-4257-8e3c-ac52f78dedd9","2024-12-20T14:35:54.785+00:00",[],"Antibiotic-microbial-assay-using-kinetic-reading-microplate-system",{"mag":1155,"keywords":1157,"openalex":1158,"abstract":1160,"title":1162,"doi":1164},{"VOID":1156},"1991063382",{},{"VOID":1159},"W1991063382",{"EN":1161},"\u003Cjats:p>The aim of this study was to determine the optimal experimental conditions to develop a methodology for microbiological assay of apramycin employing microplate and kinetic reading mode, and to validate the developed method, through evaluation of parameters of selectivity, linearity, linear range, limits of detection and quantification, accuracy and precision. The turbidimetric assay principle is simple: the test solution is added to a suspension of test microorganism in culture media, the mixture is incubated under appropriate conditions and the microbial growth is measured by photometric reading. Microplate with kinetic reading mode employed in antibiotic assay is of considerable interest since it allows reduction of material and analysis time and enables a large number of samples to be analyzed simultaneously, with automated reading and calculating. Established conditions considered the standard-curve of apramycin at concentrations from 5.0 to 35.0 μg mL-1, and tryptic soy broth inoculated with 5% Escherichia coli (ATCC 8739) suspension. Satisfactory results were obtained with 2 hours of incubation. The developed method showed appropriate selectivity, linearity in the range from 5.0 to 35.0 μg mL-1, limits of detection and quantification of 0.1 and 0.4 μg mL-1, respectively, as well as satisfactory accuracy (recuperation = 98.5%) and precision (RSD = 6.0%). Microplate assay combined the characteristics of microbiological (evaluation of antibiotic activity against sensitive test microorganism) and physico-chemical (operationally straightforward and faster results) assays.\u003C\u002Fjats:p>",{"EN":1163},"Antibiotic microbial assay using kinetic-reading microplate system",{"VOID":1165},"10.1590\u002Fs1984-82502011000300015","2024-12-20T14:35:54.784+00:00",[139],"http:\u002F\u002Fwww.scielo.br\u002Fscielo.php?script=sci_arttext&pid=S1984-82502011000300015&lng=en&tlng=en",[1170,1191],{"id":1171,"sortIndex":25,"researcher":24,"roles":1172,"affiliations":1173,"properties":1184},"f2d54767-b272-47b2-a609-e428671beedb",[],[1174],{"id":1175,"sortIndex":25,"affiliation":1176,"properties":24},"d677cf48-ae44-48a8-87f7-1043a30d8103",{"id":1177,"createTime":1178,"updateTime":1178,"relativeEntities":1179,"slug":1180,"properties":1181,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"a24217d3-b978-4fac-a427-40546daad47e","2024-12-20T14:35:54.812+00:00",[],"Sao-Paulo-Universidade-de-Sao-Paulo-Pharmaceutical-Sciences-School-Department-of-Pharmacy-Brazil",{"title":1182},{"EN":1183},"Sao Paulo, Universidade de Sao Paulo, Pharmaceutical Sciences School, Department of Pharmacy, Brazil",{"openalex":1185,"orcid":1187,"title":1189},{"VOID":1186},"A5069291017",{"VOID":1188},"https:\u002F\u002Forcid.org\u002F0000-0002-2630-151X",{"EN":1190},"Felipe Rebello Lourenço",{"id":1192,"sortIndex":104,"researcher":24,"roles":1193,"affiliations":1194,"properties":1201},"e907908c-5b64-4598-9858-ae67c3d41914",[],[1195],{"id":1196,"sortIndex":25,"affiliation":1197,"properties":24},"0440f20f-213c-4b54-ad51-8d72ffd95233",{"id":1177,"createTime":1178,"updateTime":1178,"relativeEntities":1198,"slug":1180,"properties":1199,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1200},{"EN":1183},{"openalex":1202,"orcid":1204,"title":1206},{"VOID":1203},"A5016787993",{"VOID":1205},"https:\u002F\u002Forcid.org\u002F0000-0002-0238-8227",{"EN":1207},"Terezinha de Jesus Andreoli Pinto",{"url":24,"publisher":1209,"properties":1239},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1210,"slug":10,"properties":1211,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1217,"manageAffiliations":1218,"indexDatabases":1219,"url":96,"thumbnailPath":24,"statistic":1234,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1212,"issn":1213,"introduce":1214,"eissn":1215,"title":1216},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1220,1227],{"id":78,"indexDatabase":1221,"url":91,"indexYears":92,"academicFieldIds":1226,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":1222,"label":1223,"description":1224,"key":88,"publicationTags":1225,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"id":59,"indexDatabase":1228,"url":74,"indexYears":24,"academicFieldIds":1233,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":1229,"label":1230,"description":1231,"key":70,"publicationTags":1232,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"impactFactor":25,"impactFactorByYear":1235,"i10Index":100,"i10IndexLast5Year":25,"totalPublication":101,"totalPublicationByYear":1236,"totalCitation":105,"totalCitationByYear":1237,"totalCitationPerPublication":110,"totalCitationPerPublicationByYear":1238,"hindexLast5Year":100,"hindex":100},{"2012":99},{"2010":103,"2011":104,"2013":104},{"2010":107,"2011":108,"2013":109},{"2010":112,"2011":108,"2013":109},{"volume":1240,"pages":1242,"issue":1244},{"VOID":1241},"47",{"VOID":1243},"573-584",{"VOID":768},31,{"total":1245,"publishYear":24,"statisticByYear":1247},{"2013":103,"2014":243,"2015":243,"2016":243,"2017":103,"2018":103,"2019":100,"2020":103,"2021":101,"2022":104,"2023":103,"2024":104},"2011-09-01",2011,[1251,1254,1258,1262,1266,1269,1273,1277,1280,1283,1287,1290,1294,1298,1302,1306,1310,1314,1317,1321,1325,1329,1333,1336,1339,1343,1347,1350,1354,1358,1361,1365,1369,1373,1377,1381,1385,1388,1392,1396,1400,1404,1408,1412,1415,1418,1422,1425,1429,1433,1436,1439],{"id":24,"text":1252,"url":24,"identifiers":1253},"BAMBA H., 1997, Assay for susceptibility of Helicobacter pylori to antibiotics using 96-well flat-bottom microplate and microplate reader, Rinsho Kensa, 41, 101",{},{"id":24,"text":1255,"url":24,"identifiers":1256},"ANTUNES E.A.B., 2011, Determination of apramycin in oral soluble powder by a HPLC method using pre-column derivatization with o-phthalaldehyde and UV detection, Braz. J. Pharm. Sci., 47, 261, 10.1590\u002FS1984-82502011000200007",{"doi":1257},"10.1590\u002FS1984-82502011000200007",{"id":24,"text":1259,"url":24,"identifiers":1260},"BARRET J.M., 1997, Evaluation of DNA repair inhibition by antitumor or antibiotic drugs using a chemiluminescence microplate assay, Carcinogenesis, 18, 2441, 10.1093\u002Fcarcin\u002F18.12.2441",{"doi":1261},"10.1093\u002Fcarcin\u002F18.12.2441",{"id":24,"text":1263,"url":24,"identifiers":1264},"BOGIALLI S., 2005, Simple confirmatory assay for analyzing residues of aminoglycoside antibiotics in bovine milk: hot water extraction followed by liquid chromatography-tandem mass spectrometry, J. Chromatogr. A, 1067, 93, 10.1016\u002Fj.chroma.2004.10.033",{"doi":1265},"10.1016\u002Fj.chroma.2004.10.033",{"id":24,"text":1267,"url":24,"identifiers":1268},"BOND C.R., 1948, The microbiological assay of penicillin by the turbidimetric method, using Staphylococcus aureus, Analyst, 73, 251",{},{"id":24,"text":1270,"url":24,"identifiers":1271},"BONTCHEV P.R., 1984, Spectrophotometric method for determination of tobramycin, apramycin and kanamycin in formulations, Mikrochim. Acta, 3, 459, 10.1007\u002FBF01197160",{"doi":1272},"10.1007\u002FBF01197160",{"id":24,"text":1274,"url":24,"identifiers":1275},"BORISEVICH V., 2008, A highly sensitive and versatile vírus titration assay in the 96-well microplate format, J. Virol. Methods, 147, 197, 10.1016\u002Fj.jviromet.2007.08.015",{"doi":1276},"10.1016\u002Fj.jviromet.2007.08.015",{"id":24,"text":1278,"url":24,"identifiers":1279},"BRADY M.S., 1991, Turbidimetric assay for tetracyclines in feeds using a microtiter plate system, J. Assoc. Off. Anal. Chem., 74, 465",{},{"id":24,"text":1281,"url":24,"identifiers":1282},"2008",{},{"id":24,"text":1284,"url":24,"identifiers":1285},"BURTON E., 2007, A microplate spectrofluorimetric assay for bacterial biofilms, J. Ind. Microbiol. Biotechnol., 34, 1, 10.1007\u002Fs10295-006-0086-3",{"doi":1286},"10.1007\u002Fs10295-006-0086-3",{"id":24,"text":1288,"url":24,"identifiers":1289},"COOPER K.E., 1963, The theory of antibiotic inhibition zones, 1",{},{"id":24,"text":1291,"url":24,"identifiers":1292},"FALK C.R., 1953, Adaptation of antibiotic assay methods for routine use, Am. J. Public Health, 43, 419, 10.2105\u002FAJPH.43.4.419",{"doi":1293},"10.2105\u002FAJPH.43.4.419",{"id":24,"text":1295,"url":24,"identifiers":1296},"FIELDING J., 1947, A simple method of estimating penicillin and other bacteriostatics, Br. Med. J., 1, 136, 10.1136\u002Fbmj.1.4490.136",{"doi":1297},"10.1136\u002Fbmj.1.4490.136",{"id":24,"text":1299,"url":24,"identifiers":1300},"FLEMING A., 1944, Micromethods of estimating penicillin in blood serum, Lancet, 247, 620, 10.1016\u002FS0140-6736(00)45985-4",{"doi":1301},"10.1016\u002FS0140-6736(00)45985-4",{"id":24,"text":1303,"url":24,"identifiers":1304},"FLEMING A., 1947, Estimation of penicillin in serum use of glucose, phenol red, and serum water, Lancet, 252, 401, 10.1016\u002FS0140-6736(47)91225-7",{"doi":1305},"10.1016\u002FS0140-6736(47)91225-7",{"id":24,"text":1307,"url":24,"identifiers":1308},"FOSTER J.W., 1943, Microbiological aspects of penicillin: I. Methods of assay, J. Bacteriol., 46, 187, 10.1128\u002FJB.46.2.187-202.1943",{"doi":1309},"10.1128\u002FJB.46.2.187-202.1943",{"id":24,"text":1311,"url":24,"identifiers":1312},"HERMANN T., 2007, Apramycin recognition by human ribosomal decoding site, Blood Cells Mol. Dis., 38, 193, 10.1016\u002Fj.bcmd.2006.11.006",{"doi":1313},"10.1016\u002Fj.bcmd.2006.11.006",{"id":24,"text":1315,"url":24,"identifiers":1316},"HEWITT W., 1977",{},{"id":24,"text":1318,"url":24,"identifiers":1319},"HOLOWACHUK S.A., 2003, A kinetic microplate method for quantifying the antibacterial properties of biological fluids, J. Microbiol. Methods, 55, 441, 10.1016\u002FS0167-7012(03)00190-8",{"doi":1320},"10.1016\u002FS0167-7012(03)00190-8",{"id":24,"text":1322,"url":24,"identifiers":1323},"ISOHERRANEN N., 1999, Chromatographic Methods for Analysis of Aminoglycoside Antibiotics, J. AOAC Int., 82, 1017, 10.1093\u002Fjaoac\u002F82.5.1017",{"doi":1324},"10.1093\u002Fjaoac\u002F82.5.1017",{"id":24,"text":1326,"url":24,"identifiers":1327},"JOSLYN D.A., 1944, Penicillin assay: Outline of four-hour turbidimetric method, Science, 99, 21, 10.1126\u002Fscience.99.2558.21",{"doi":1328},"10.1126\u002Fscience.99.2558.21",{"id":24,"text":1330,"url":24,"identifiers":1331},"JOSLYN D.A., 1950, A turbidimetric method for the assay of antibiotics, J. Bacteriol., 59, 711, 10.1128\u002FJB.59.6.711-716.1950",{"doi":1332},"10.1128\u002FJB.59.6.711-716.1950",{"id":24,"text":1334,"url":24,"identifiers":1335},"JOSLYN D.A., 1963, Elements of photometric assaying, 141",{},{"id":24,"text":1337,"url":24,"identifiers":1338},"JOSLYN D.A., 1972, Photometric assaying, II, 43",{},{"id":24,"text":1340,"url":24,"identifiers":1341},"LAMAR J., 2007, Development of a receptor microplate assay for detection of beta-lactam antibiotics in different food matrices, Anal. Chim. Acta, 586, 296, 10.1016\u002Fj.aca.2006.09.032",{"doi":1342},"10.1016\u002Fj.aca.2006.09.032",{"id":24,"text":1344,"url":24,"identifiers":1345},"LETHINEN J., 2006, Real-time monitoring of antimicrobial activity with the multiparameter microplate assay, J. Microbiol. Methods, 66, 381, 10.1016\u002Fj.mimet.2006.01.002",{"doi":1346},"10.1016\u002Fj.mimet.2006.01.002",{"id":24,"text":1348,"url":24,"identifiers":1349},"LOURENÇO F.R., 2011, Microbiological assay for apramycin soluble powder, Lat. Am. J. Pharm., 30, 554",{},{"id":24,"text":1351,"url":24,"identifiers":1352},"LOVERING A.M., 1984, Identification of aminoglycoside - acetylating enzymes by high pressure liquid chromatographic determination of their reaction products, Antimicrob. Agents Chemother., 26, 10, 10.1128\u002FAAC.26.1.10",{"doi":1353},"10.1128\u002FAAC.26.1.10",{"id":24,"text":1355,"url":24,"identifiers":1356},"LOY H.W., 1959, Microbiological assay of amino acids, vitamins and antibiotics: Application of tube methods, Anal. Chem., 3l, 971, 10.1021\u002Fac60150a039",{"doi":1357},"10.1021\u002Fac60150a039",{"id":24,"text":1359,"url":24,"identifiers":1360},"2007, 35",{},{"id":24,"text":1362,"url":24,"identifiers":1363},"MAYO L.A., 1990, Kinetic microplate assay for superoxide production by neutrophilis and other phagocytic cells, Methods Enzymol., 186, 567, 10.1016\u002F0076-6879(90)86151-K",{"doi":1364},"10.1016\u002F0076-6879(90)86151-K",{"id":24,"text":1366,"url":24,"identifiers":1367},"MCMAHAN J.R., 1944, An improved short time turbidimetric assay for penicillin, J. Biol. Chem., 153, 249, 10.1016\u002FS0021-9258(18)51231-X",{"doi":1368},"10.1016\u002FS0021-9258(18)51231-X",{"id":24,"text":1370,"url":24,"identifiers":1371},"MEGOULAS N.C., 2005, Development and validation of a novel HPLC\u002FELSD method for the direct determination of tobramycin in pharmaceuticals, plasma and urine, Anal. Bioanal. Chem., 382, 290, 10.1007\u002Fs00216-004-2948-8",{"doi":1372},"10.1007\u002Fs00216-004-2948-8",{"id":24,"text":1374,"url":24,"identifiers":1375},"O'CONNOR S., 1976, Apramycin, a unique aminocyclitol antibiotic, J. Org. Chem., 41, 2087, 10.1021\u002Fjo00874a003",{"doi":1376},"10.1021\u002Fjo00874a003",{"id":24,"text":1378,"url":24,"identifiers":1379},"PERZYNSKI S., 1979, Effects of apramycin, a novel aminoglycoside antibiotic on bacterial protein synthesis, Eur. J. Biochem., 99, 623, 10.1111\u002Fj.1432-1033.1979.tb13295.x",{"doi":1380},"10.1111\u002Fj.1432-1033.1979.tb13295.x",{"id":24,"text":1382,"url":24,"identifiers":1383},"PETTIT R.K., 2005, Microplate alamar blue assay for Staphylococcus epidermidis biofilm susceptibility testing, Antimicrob. Agents Chemother., 49, 2612, 10.1128\u002FAAC.49.7.2612-2617.2005",{"doi":1384},"10.1128\u002FAAC.49.7.2612-2617.2005",{"id":24,"text":1386,"url":24,"identifiers":1387},"PINTO T.J.A., 2003",{},{"id":24,"text":1389,"url":24,"identifiers":1390},"POLTA J.A., 1985, Liquid chromatographic separation of aminoglycosides with pulsed amperometric detection, J. Chromatogr., 324, 407, 10.1016\u002FS0021-9673(01)81339-X",{"doi":1391},"10.1016\u002FS0021-9673(01)81339-X",{"id":24,"text":1393,"url":24,"identifiers":1394},"RAMMELKAMP C.H., 1942, A method for determining the concentration of penicillin in body fluids and exsudates, Proc. Soc. Exp. Biol. Med., 51, 95, 10.3181\u002F00379727-51-13844",{"doi":1395},"10.3181\u002F00379727-51-13844",{"id":24,"text":1397,"url":24,"identifiers":1398},"SERRANO J.M., 2006, Rapid and sensitive determination of aminoglycoside antibiotics in water samples using a strong cation-exchange chromatography non-derivatisation method with chemiluminescence detection, J. Chromatogr. A, 1117, 176, 10.1016\u002Fj.chroma.2006.03.086",{"doi":1399},"10.1016\u002Fj.chroma.2006.03.086",{"id":24,"text":1401,"url":24,"identifiers":1402},"SMITH S.M., 2008, An enhanced miniaturized assay for antimicrobial prospecting, J. Microbiol. Methods, 72, 103, 10.1016\u002Fj.mimet.2007.10.003",{"doi":1403},"10.1016\u002Fj.mimet.2007.10.003",{"id":24,"text":1405,"url":24,"identifiers":1406},"STEAD D.A., 2000, Current methodologies for the analysis of aminoglycosides, J. Chromatogr. B, 747, 69, 10.1016\u002FS0378-4347(00)00133-X",{"doi":1407},"10.1016\u002FS0378-4347(00)00133-X",{"id":24,"text":1409,"url":24,"identifiers":1410},"SWEENEY D.J., 1998, Determination of apramycin in swine kidney tissue by liquid chromatography with fluorescence detection, J. AOAC Int., 81, 1141, 10.1093\u002Fjaoac\u002F81.6.1141",{"doi":1411},"10.1093\u002Fjaoac\u002F81.6.1141",{"id":24,"text":1413,"url":24,"identifiers":1414},"TAMURA H., 1990, Methodological and clinical evaluation of a microplate assay of endotoxin in whole blood sample, Igaku no Ayumi, 38, 1341",{},{"id":24,"text":1416,"url":24,"identifiers":1417},"TAMURA H., 1991, Sensitive microplate method for plasma endotoxin assay, Igaku no Ayumi, 158, 227",{},{"id":24,"text":1419,"url":24,"identifiers":1420},"TAMURA H., 1992, A new sensitive microplate assay of plasma endotoxin, J. Clin. Lab. Anal., 6, 232, 10.1002\u002Fjcla.1860060412",{"doi":1421},"10.1002\u002Fjcla.1860060412",{"id":24,"text":1423,"url":24,"identifiers":1424},"TAMURA H., 1993, A new kinetic automated microplate assy of endotoxin and (1®3)-β-D-glucan, Igaku no Ayumi, 166, 811",{},{"id":24,"text":1426,"url":24,"identifiers":1427},"TATSUTA K., 1984, Total synthesis of aminoglycoside antibiotics, apramycin and saccharocin (KA-5685), Chem. Soc. Japan, 57, 529, 10.1246\u002Fbcsj.57.529",{"doi":1428},"10.1246\u002Fbcsj.57.529",{"id":24,"text":1430,"url":24,"identifiers":1431},"WALTON J.R., 1978, Apramycin, a new aminocyclitol antibiotic: I. In vitro microbiological studies, J. Antimicrobiol. Chemoth, 4, 309, 10.1093\u002Fjac\u002F4.4.309",{"doi":1432},"10.1093\u002Fjac\u002F4.4.309",{"id":24,"text":1434,"url":24,"identifiers":1435},"YAMAMOTO C.H., 1999",{},{"id":24,"text":1437,"url":24,"identifiers":1438},"ZHANG L., 2007, Determination of Apramycin in Animal Feeds by Solid-Phase Extraction and Liquid Chromatography with Precolumn Derivatization and Fluorescence Detection, J. AOAC. Int., 90, 885",{},{"id":24,"text":1440,"url":24,"identifiers":1441},"ZHONG G., 1994, Kinetic microplate assay of titering microbial cells, BioTechiques, 16, 838",{},{"id":1443,"createTime":1444,"updateTime":1444,"relativeEntities":1445,"slug":1446,"properties":1447,"entityType":134,"verifyStatus":135,"verifyTime":1444,"verifyNote":137,"syncStatus":23,"languages":1459,"translateLanguages":24,"viewCount":25,"primaryUrl":1460,"fullTextUrl":24,"authors":1461,"publicationType":201,"publisherRelationship":1567,"citationCount":1604,"citationInfo":1605,"publishDate":1607,"publishYear":1608,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1609,"isForceReanalyzing":449},"5a1d9de6-be9b-44dd-8cba-46ee0f5d143c","2025-02-01T09:53:11.335+00:00",[],"Formulation-design-and-characterization-of-a-non-ionic-surfactant-based-vesicular-system-for-the-sustained-delivery-of-a-new-chondroprotective-agent",{"mag":1448,"keywords":1450,"openalex":1451,"abstract":1453,"title":1455,"doi":1457},{"VOID":1449},"2184622055",{},{"VOID":1452},"W2184622055",{"EN":1454},"\u003Cjats:p>Diacerein is used for symptomatic relief and cartilage regeneration in osteoarthritis. Due to gastrointestinal side effects, poor aqueous solubility and low bioavailability, its clinical usage has been restricted. The objective of the present study was to enhance its dissolution profile and to attain sustained release by designing a novel delivery system based on niosomes. Five niosomal formulations (F1-F5) with non-ionic surfactant (sorbitan monostearate) and cholesterol in varying ratios of 5:5, 6:4, 7:3, 8:2 and 9:1 were developed by the reverse-phase evaporation technique. The size and polydispersivity index (PDI) were found in the range of 0.608 µm to 1.010 µm and 0.409 to 0.781, respectively. Scanning electron microscopy (SEM) of the selected formulation (F3) revealed spherical vesicles, and 79.8% entrapment was achieved with F3 (7:3). Dissolution studies using the dialysis method showed sustained release behaviour for all formulations. The optimized surfactant-to-cholesterol concentration (7:3) in formulation F3sustained the drug-release time (T50%) up to 10 hours. Kinetic modelling exhibited a zero-order release (R2=0.9834) and the release exponent 'n' of the Korsmayer-Peppas model (n=0.90) confirmed non-fickian and anomalous release. The results of this study suggest that diacerein can be successfully entrapped into niosomes using sorbitan monostearate and that these niosomes have the potential to deliver diacerein efficiently at the absorption site.\u003C\u002Fjats:p>",{"EN":1456},"Formulation design and characterization of a non-ionic surfactant based vesicular system for the sustained delivery of a new chondroprotective agent",{"VOID":1458},"10.1590\u002Fs1984-82502015000300012",[139],"http:\u002F\u002Fwww.scielo.br\u002Fscielo.php?script=sci_arttext&pid=S1984-82502015000300607&lng=en&tlng=en",[1462,1484,1501,1516,1533,1550],{"id":1463,"sortIndex":103,"researcher":24,"roles":1464,"affiliations":1465,"properties":1477},"9ae289a0-e26e-4460-a2b5-8103efbdb0c8",[],[1466],{"id":1467,"sortIndex":25,"affiliation":1468,"properties":24},"8740c3d8-f976-42ad-813b-e8ff3efffe78",{"id":1469,"createTime":1470,"updateTime":1471,"relativeEntities":1472,"slug":1473,"properties":1474,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"79efd412-98c4-4c10-ae52-0d8bf2a2f3ec","2023-11-26T17:16:54.388+00:00","2025-02-01T09:53:11.459+00:00",[],"Department-of-Pharmacy-The-Islamia-University-of-Bahawalpur-Bahawalpur-Pakistan",{"title":1475},{"VI":1476},"Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan",{"openalex":1478,"orcid":1480,"title":1482},{"VOID":1479},"A5103737293",{"VOID":1481},"https:\u002F\u002Forcid.org\u002F0000-0002-0925-466X",{"EN":1483},"Saeed Ahmad",{"id":1485,"sortIndex":101,"researcher":24,"roles":1486,"affiliations":1487,"properties":1494},"52f4837e-c804-4504-a861-0c9f0857bd12",[],[1488],{"id":1489,"sortIndex":25,"affiliation":1490,"properties":24},"fea9d685-6d13-4650-9d23-6607623975c6",{"id":1469,"createTime":1470,"updateTime":1471,"relativeEntities":1491,"slug":1473,"properties":1492,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1493},{"VI":1476},{"openalex":1495,"orcid":1497,"title":1499},{"VOID":1496},"A5018910880",{"VOID":1498},"https:\u002F\u002Forcid.org\u002F0000-0001-6663-8777",{"EN":1500},"Muhammad Ashfaq",{"id":1502,"sortIndex":243,"researcher":24,"roles":1503,"affiliations":1504,"properties":1511},"de4f7e00-4df4-45de-a8cc-0046f314c3fa",[],[1505],{"id":1506,"sortIndex":25,"affiliation":1507,"properties":24},"c5dc482b-543f-4d91-a0ee-1d82c03e3717",{"id":1469,"createTime":1470,"updateTime":1471,"relativeEntities":1508,"slug":1473,"properties":1509,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1510},{"VI":1476},{"openalex":1512,"title":1514},{"VOID":1513},"A5054275101",{"EN":1515},"Muhammad Ahmad Mahmood",{"id":1517,"sortIndex":100,"researcher":24,"roles":1518,"affiliations":1519,"properties":1526},"125ed2e3-df80-43ab-bc88-4ed0e1d2712b",[],[1520],{"id":1521,"sortIndex":25,"affiliation":1522,"properties":24},"66ce0024-3a39-40bf-be2d-7c1dd3457c5c",{"id":1469,"createTime":1470,"updateTime":1471,"relativeEntities":1523,"slug":1473,"properties":1524,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1525},{"VI":1476},{"openalex":1527,"orcid":1529,"title":1531},{"VOID":1528},"A5024303082",{"VOID":1530},"https:\u002F\u002Forcid.org\u002F0000-0002-7605-8861",{"EN":1532},"Mubashar Rehman",{"id":1534,"sortIndex":104,"researcher":24,"roles":1535,"affiliations":1536,"properties":1543},"e1f8cd9a-6145-4482-89a2-56d39b46a87f",[],[1537],{"id":1538,"sortIndex":25,"affiliation":1539,"properties":24},"4792f31f-0d4f-4ad3-a633-4cdbdc0bbdde",{"id":1469,"createTime":1470,"updateTime":1471,"relativeEntities":1540,"slug":1473,"properties":1541,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1542},{"VI":1476},{"openalex":1544,"orcid":1546,"title":1548},{"VOID":1545},"A5004295238",{"VOID":1547},"https:\u002F\u002Forcid.org\u002F0000-0002-0388-9867",{"EN":1549},"Asadullah Madni",{"id":1551,"sortIndex":25,"researcher":24,"roles":1552,"affiliations":1553,"properties":1560},"86bc2835-f573-4abf-9bd2-d7a6e297a7c6",[],[1554],{"id":1555,"sortIndex":25,"affiliation":1556,"properties":24},"7a4aa880-5b8e-4349-8f8e-98c0d9a6f28f",{"id":1469,"createTime":1470,"updateTime":1471,"relativeEntities":1557,"slug":1473,"properties":1558,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1559},{"VI":1476},{"openalex":1561,"orcid":1563,"title":1565},{"VOID":1562},"A5045286608",{"VOID":1564},"https:\u002F\u002Forcid.org\u002F0000-0002-6675-0491",{"EN":1566},"Muhammad Imran Khan",{"url":24,"publisher":1568,"properties":1598},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1569,"slug":10,"properties":1570,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1576,"manageAffiliations":1577,"indexDatabases":1578,"url":96,"thumbnailPath":24,"statistic":1593,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1571,"issn":1572,"introduce":1573,"eissn":1574,"title":1575},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1579,1586],{"id":78,"indexDatabase":1580,"url":91,"indexYears":92,"academicFieldIds":1585,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":1581,"label":1582,"description":1583,"key":88,"publicationTags":1584,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"id":59,"indexDatabase":1587,"url":74,"indexYears":24,"academicFieldIds":1592,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":1588,"label":1589,"description":1590,"key":70,"publicationTags":1591,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"impactFactor":25,"impactFactorByYear":1594,"i10Index":100,"i10IndexLast5Year":25,"totalPublication":101,"totalPublicationByYear":1595,"totalCitation":105,"totalCitationByYear":1596,"totalCitationPerPublication":110,"totalCitationPerPublicationByYear":1597,"hindexLast5Year":100,"hindex":100},{"2012":99},{"2010":103,"2011":104,"2013":104},{"2010":107,"2011":108,"2013":109},{"2010":112,"2011":108,"2013":109},{"volume":1599,"pages":1601,"issue":1603},{"VOID":1600},"51",{"VOID":1602},"607-615",{"VOID":768},35,{"total":1604,"publishYear":24,"statisticByYear":1606},{"2016":104,"2018":101,"2019":103,"2020":548,"2021":100,"2022":548,"2023":100,"2024":243},"2015-09-01",2015,[1610,1614,1617,1621,1625,1629,1633,1636,1639,1643,1647,1651,1655,1659,1663,1667,1671,1675,1678,1682,1686,1690,1693,1697,1701,1705,1709,1713,1717,1720,1723,1727,1731,1735],{"id":24,"text":1611,"url":24,"identifiers":1612},"AGGARWAL A.K., 2011, Physicochemical characterization and dissolution study of solid dispersions of diacerein with polyethylene glycol 6000, Drug Dev. Ind. Pharm., 37, 1181, 10.3109\u002F03639045.2011.563782",{"doi":1613},"10.3109\u002F03639045.2011.563782",{"id":24,"text":1615,"url":24,"identifiers":1616},"ABDELKADER H., 2010, Preparation of niosomes as an ocular delivery system for naltrexone hydrochloride: physicochemical characterization, Pharmazie, 65, 811",{},{"id":24,"text":1618,"url":24,"identifiers":1619},"ABDELKADER H., 2012, Niosomes and discomes for oculardelivery of naltrexone hydrochloride: morphological, rheological, spreading properties and photo-protective effects, Int. J. Pharm., 433, 142, 10.1016\u002Fj.ijpharm.2012.05.011",{"doi":1620},"10.1016\u002Fj.ijpharm.2012.05.011",{"id":24,"text":1622,"url":24,"identifiers":1623},"ATTIA I.A., 2007, Influence of a niosomal formulation on the oral bioavailability of acyclovir in rabbits, AAPS Pharm. Sci. Tech., 8, 10.1208\u002Fpt0804106",{"doi":1624},"10.1208\u002Fpt0804106",{"id":24,"text":1626,"url":24,"identifiers":1627},"ALSARRA I.A., 2005, Proniosomes as a drug carrier for transdermal delivery of ketorolac, Eur. J. Pharm. Biopharm., 59, 485, 10.1016\u002Fj.ejpb.2004.09.006",{"doi":1628},"10.1016\u002Fj.ejpb.2004.09.006",{"id":24,"text":1630,"url":24,"identifiers":1631},"COSTA P., 2001, Modeling and comparison of dissolution profiles, Eur. J. Pharm. Sci., 13, 123, 10.1016\u002FS0928-0987(01)00095-1",{"doi":1632},"10.1016\u002FS0928-0987(01)00095-1",{"id":24,"text":1634,"url":24,"identifiers":1635},"DESHMUKH D.B., 2010, Dissolution enhancement of poorly water soluble diacerein by solid dispersion technique, J. Pharm Sci. Res., 2, 734",{},{"id":24,"text":1637,"url":24,"identifiers":1638},"DASH S., 2010, Kinetic modeling on drug release from controlled drug delivery systems, Acta Pol. Pharm., 67, 217",{},{"id":24,"text":1640,"url":24,"identifiers":1641},"DEMEL R.A., 1976, The function of sterols in membranes, Biochim. Biophys Acta, 457, 109, 10.1016\u002F0304-4157(76)90008-3",{"doi":1642},"10.1016\u002F0304-4157(76)90008-3",{"id":24,"text":1644,"url":24,"identifiers":1645},"ESSA E.A., 2010, Effect of formulation and processing variables on the particle size of sorbitan monopalmitate niosomes, Asian J. Pharm., 4, 227, 10.4103\u002F0973-8398.76752",{"doi":1646},"10.4103\u002F0973-8398.76752",{"id":24,"text":1648,"url":24,"identifiers":1649},"GIRIGOSWAMI A., 2006, Fluorescence and dynamic light scattering studies of niosomes membrane mimetic systems, Spectrochim. Acta. A. Mol. Biomol. Spectrosc., 64, 859, 10.1016\u002Fj.saa.2005.08.015",{"doi":1650},"10.1016\u002Fj.saa.2005.08.015",{"id":24,"text":1652,"url":24,"identifiers":1653},"GUINEDI A.S., 2005, Preparation and evaluation of reverse phase evaporation and multilamellar niosomes as ophthalmic carriers of acetazolamide, Int. J. Pharm., 306, 71, 10.1016\u002Fj.ijpharm.2005.09.023",{"doi":1654},"10.1016\u002Fj.ijpharm.2005.09.023",{"id":24,"text":1656,"url":24,"identifiers":1657},"HONG M., 2009, Efficient tumor targeting of hydroxycamptothecin loaded PEGylated niosomes modified with transferrin, J. Control. Release, 133, 96, 10.1016\u002Fj.jconrel.2008.09.005",{"doi":1658},"10.1016\u002Fj.jconrel.2008.09.005",{"id":24,"text":1660,"url":24,"identifiers":1661},"HUNTER D.J., 2007, Review: diacerein is more effective than placebo, J. Evid. Based Med., 12, 74, 10.1136\u002Febm.12.3.74",{"doi":1662},"10.1136\u002Febm.12.3.74",{"id":24,"text":1664,"url":24,"identifiers":1665},"JAIN A., 2013, Development of lipid nanoparticles of diacerein, an antiosteoarthritic drug for enhancement in bioavailability and reduction in its side effects, J. Biomed. Nanotechnol., 9, 891, 10.1166\u002Fjbn.2013.1580",{"doi":1666},"10.1166\u002Fjbn.2013.1580",{"id":24,"text":1668,"url":24,"identifiers":1669},"JAIN C., 1995, Preparation and characterization of niosomes containing rifampicin for lung targeting, J. Microencapsul., 12, 401, 10.3109\u002F02652049509087252",{"doi":1670},"10.3109\u002F02652049509087252",{"id":24,"text":1672,"url":24,"identifiers":1673},"KORCHOWIEC B., 2006, A Langmuir film approach to elucidating interactions in lipid membranes: 1, 2-dipalmitoyl glycero-3phosphoethanolamine cholesterol metal cation systems, Chem. Phys. Lipids, 144, 127, 10.1016\u002Fj.chemphyslip.2006.08.005",{"doi":1674},"10.1016\u002Fj.chemphyslip.2006.08.005",{"id":24,"text":1676,"url":24,"identifiers":1677},"LI F.T., 2008, Research on surface-modification of Nano-TiO2 by span 60, J. Ceram. Process. Res., 9, 398",{},{"id":24,"text":1679,"url":24,"identifiers":1680},"MAHALE N., 2012, Niosomes: novel sustained release nonionic stable vesicular systems-an overview, Adv. Colloid. Interface Sci., 183-184, 46, 10.1016\u002Fj.cis.2012.08.002",{"doi":1681},"10.1016\u002Fj.cis.2012.08.002",{"id":24,"text":1683,"url":24,"identifiers":1684},"MANOSROI A., 2003, Characterization of vesicles prepared with various non-ionic surfactants mixed with cholesterol, Colloids Surf. B Biointerfaces, 30, 129, 10.1016\u002FS0927-7765(03)00080-8",{"doi":1685},"10.1016\u002FS0927-7765(03)00080-8",{"id":24,"text":1687,"url":24,"identifiers":1688},"MARIANECCI C., 2012, Anti-inflammatory activity of novel ammonium glycyrrhizinate\u002Fniosomes delivery system: human and murine models, J. Control. Release, 164, 17, 10.1016\u002Fj.jconrel.2012.09.018",{"doi":1689},"10.1016\u002Fj.jconrel.2012.09.018",{"id":24,"text":1691,"url":24,"identifiers":1692},"MASKI N., 2009, Studies on the preparation, characterization and solubility of β-cyclodextrin-diacerein inclusion complexes, Int. J. Pharm. Pharm. Sci., 1, 121",{},{"id":24,"text":1694,"url":24,"identifiers":1695},"MOAZENI E., 2010, Formulation and in vitro evaluation of ciprofloxacin containing niosomes for pulmonary delivery, J. Microencapsul., 27, 618, 10.3109\u002F02652048.2010.506579",{"doi":1696},"10.3109\u002F02652048.2010.506579",{"id":24,"text":1698,"url":24,"identifiers":1699},"MUZZALUPO R., 2008, Niosomes from α, ω-trioxyethylene-bis (sodium 2-dodecyloxy-propylenesulfonate): Preparation and characterization, Colloids. Surf. B Biointerfaces, 64, 200, 10.1016\u002Fj.colsurfb.2008.01.026",{"doi":1700},"10.1016\u002Fj.colsurfb.2008.01.026",{"id":24,"text":1702,"url":24,"identifiers":1703},"NGUYEN M., 1994, Diacerhein in the treatment of osteoarthritis of the hip, Arthritis Rheum., 37, 529, 10.1002\u002Fart.1780370413",{"doi":1704},"10.1002\u002Fart.1780370413",{"id":24,"text":1706,"url":24,"identifiers":1707},"PARDAKHTY A., 2007, In vitro study of polyoxyethylene alkyl ether niosomes for delivery of insulin, Int. J. Pharm., 328, 130, 10.1016\u002Fj.ijpharm.2006.08.002",{"doi":1708},"10.1016\u002Fj.ijpharm.2006.08.002",{"id":24,"text":1710,"url":24,"identifiers":1711},"PEARLE A.D., 2005, Basic science of articular cartilage and osteoarthritis, Clin. Sports Med., 24, 1, 10.1016\u002Fj.csm.2004.08.007",{"doi":1712},"10.1016\u002Fj.csm.2004.08.007",{"id":24,"text":1714,"url":24,"identifiers":1715},"REIS O., 1996, The effect of high extenal pressure on DPPC-cholesterol multilammellar vesicles: a pressure-tuning Fourier transform infrared spectroscopy, Biochim. Biophys. Acta, 1279, 5, 10.1016\u002F0005-2736(95)00233-2",{"doi":1716},"10.1016\u002F0005-2736(95)00233-2",{"id":24,"text":1718,"url":24,"identifiers":1719},"SHARI M.L., 2012",{},{"id":24,"text":1721,"url":24,"identifiers":1722},"SILVERSTEIN R.M., 2005, 7., 512 p",{},{"id":24,"text":1724,"url":24,"identifiers":1725},"UCHEGBU I.F., 1995, Distribution, metabolism and tumoricidal activity of doxorubicin administered in sorbitan monostearate (Span 60) niosomes in the mouse, Pharm. Res., 12, 1019, 10.1023\u002FA:1016210515134",{"doi":1726},"10.1023\u002FA:1016210515134",{"id":24,"text":1728,"url":24,"identifiers":1729},"UCHEGBU I.F., 1998, Non-ionic surfactant based vesicles (niosomes) in drug delivery, Int. J. Pharm., 172, 33, 10.1016\u002FS0378-5173(98)00169-0",{"doi":1730},"10.1016\u002FS0378-5173(98)00169-0",{"id":24,"text":1732,"url":24,"identifiers":1733},"WADDAD A.Y., 2013, Formulation, characterization and pharmacokinetics of Morin hydrate niosomes prepared from various non-ionic surfactants, Int. J. Pharm., 456, 446, 10.1016\u002Fj.ijpharm.2013.08.040",{"doi":1734},"10.1016\u002Fj.ijpharm.2013.08.040",{"id":24,"text":1736,"url":24,"identifiers":1737},"YOSHIOKA T., 1994, Preparation and properties of vesicles (niosomes) of sorbitan monoesters (Span 20, 40, 60 and 80) and a sorbitan triester (Span 85), Int. J. Pharm., 105, 1, 10.1016\u002F0378-5173(94)90228-3",{"doi":1738},"10.1016\u002F0378-5173(94)90228-3",{"id":1740,"createTime":1741,"updateTime":1741,"relativeEntities":1742,"slug":1743,"properties":1744,"entityType":134,"verifyStatus":135,"verifyTime":1741,"verifyNote":137,"syncStatus":23,"languages":1756,"translateLanguages":24,"viewCount":25,"primaryUrl":1757,"fullTextUrl":24,"authors":1758,"publicationType":201,"publisherRelationship":1813,"citationCount":1849,"citationInfo":1850,"publishDate":1068,"publishYear":246,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1853,"isForceReanalyzing":449},"002b4736-e08d-4824-a5e5-2eead4e67a17","2024-10-17T08:58:08.910+00:00",[],"Thermodynamic-study-of-the-solubility-of-ibuprofen-in-acetone-and-dichloromethane",{"mag":1745,"keywords":1747,"openalex":1748,"abstract":1750,"title":1752,"doi":1754},{"VOID":1746},"2070987395",{},{"VOID":1749},"W2070987395",{"EN":1751},"\u003Cjats:p>Thermodynamic functions, Gibbs energy, enthalpy and entropy for the solution processes of ibuprofen (IBP) in acetone and dichloromethane (DCM) were calculated from solubility values obtained at temperatures ranging from 293.15 K to 313.15 K. The respective thermodynamic functions for mixing and solvation processes as well as the activity coefficients for the solute were calculated. IBP solubility was high and proved similar in both solvents but was greater in DCM than acetone. In addition, the thermodynamic quantities for the transfer process of this drug from cyclohexane to the organic solvents were also calculated in order to estimate the contributions of hydrogen-bonds or of other dipolar interactions. The results were discussed in terms of solute-solvent interactions.\u003C\u002Fjats:p>",{"EN":1753},"Thermodynamic study of the solubility of ibuprofen in acetone and dichloromethane",{"VOID":1755},"10.1590\u002Fs1984-82502010000200009",[139],"http:\u002F\u002Fwww.scielo.br\u002Fscielo.php?script=sci_arttext&pid=S1984-82502010000200009&lng=en&tlng=en",[1759,1781,1796],{"id":1760,"sortIndex":25,"researcher":24,"roles":1761,"affiliations":1762,"properties":1774},"def500f2-46a7-417c-96ec-c1bd403706fc",[],[1763],{"id":1764,"sortIndex":25,"affiliation":1765,"properties":24},"05a4632f-35ca-43a0-b188-c416e6497be1",{"id":1766,"createTime":1767,"updateTime":1768,"relativeEntities":1769,"slug":1770,"properties":1771,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"35e1018f-fab0-47da-895c-ff4acc92eccc","2024-04-19T21:38:11.508+00:00","2025-11-21T09:57:58.948+00:00",[],"Universidad-Nacional-de-Colombia-",{"title":1772},{"EN":1773},"Universidad Nacional de Colombia,",{"openalex":1775,"orcid":1777,"title":1779},{"VOID":1776},"A5008167130",{"VOID":1778},"https:\u002F\u002Forcid.org\u002F0000-0003-2862-3771",{"EN":1780},"Diana Marcela Aragón",{"id":1782,"sortIndex":104,"researcher":24,"roles":1783,"affiliations":1784,"properties":1791},"5274700b-95dc-49d5-8b70-e1a14848df63",[],[1785],{"id":1786,"sortIndex":25,"affiliation":1787,"properties":24},"69a088f8-8b5a-4d9c-b245-cec9f52be8d1",{"id":1766,"createTime":1767,"updateTime":1768,"relativeEntities":1788,"slug":1770,"properties":1789,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1790},{"EN":1773},{"openalex":1792,"title":1794},{"VOID":1793},"A5102137326",{"EN":1795},"Jaiver Rosas",{"id":1797,"sortIndex":103,"researcher":24,"roles":1798,"affiliations":1799,"properties":1806},"0a03006d-c8fd-47d2-ba0f-1a51aab6ecbd",[],[1800],{"id":1801,"sortIndex":25,"affiliation":1802,"properties":24},"31bb1ff2-eeb3-4345-8843-3aef32472e73",{"id":1766,"createTime":1767,"updateTime":1768,"relativeEntities":1803,"slug":1770,"properties":1804,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1805},{"EN":1773},{"openalex":1807,"orcid":1809,"title":1811},{"VOID":1808},"A5075934794",{"VOID":1810},"https:\u002F\u002Forcid.org\u002F0000-0002-4008-7273",{"EN":1812},"Fleming Martínez",{"url":24,"publisher":1814,"properties":1844},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1815,"slug":10,"properties":1816,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1822,"manageAffiliations":1823,"indexDatabases":1824,"url":96,"thumbnailPath":24,"statistic":1839,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":1817,"issn":1818,"introduce":1819,"eissn":1820,"title":1821},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[1825,1832],{"id":78,"indexDatabase":1826,"url":91,"indexYears":92,"academicFieldIds":1831,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":1827,"label":1828,"description":1829,"key":88,"publicationTags":1830,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"id":59,"indexDatabase":1833,"url":74,"indexYears":24,"academicFieldIds":1838,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":1834,"label":1835,"description":1836,"key":70,"publicationTags":1837,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"impactFactor":25,"impactFactorByYear":1840,"i10Index":100,"i10IndexLast5Year":25,"totalPublication":101,"totalPublicationByYear":1841,"totalCitation":105,"totalCitationByYear":1842,"totalCitationPerPublication":110,"totalCitationPerPublicationByYear":1843,"hindexLast5Year":100,"hindex":100},{"2012":99},{"2010":103,"2011":104,"2013":104},{"2010":107,"2011":108,"2013":109},{"2010":112,"2011":108,"2013":109},{"volume":1845,"pages":1846,"issue":1848},{"VOID":235},{"VOID":1847},"227-235",{"VOID":544},59,{"total":1849,"publishYear":24,"statisticByYear":1851},{"2012":103,"2013":104,"2014":103,"2016":103,"2018":243,"2019":1067,"2020":548,"2021":101,"2022":1067,"2023":1852,"2024":100},12,[1854,1857,1860,1863,1867,1871,1875,1878,1881,1885,1889,1892,1896,1899,1902,1906,1909,1912,1915,1919],{"id":24,"text":1855,"url":24,"identifiers":1856},"BARTON A, 1991, 2, 157",{},{"id":24,"text":1858,"url":24,"identifiers":1859},"BEVINGTON P. R, 1969, 56",{},{"id":24,"text":1861,"url":24,"identifiers":1862},"BUDAVARI S, 2001, 13",{},{"id":24,"text":1864,"url":24,"identifiers":1865},"BUSTAMANTE P, 1998, Enthalpy-entropy compensation for the solubility of drugs in solvent mixtures: Paracetamol, acetanilide, and nalidixic acid in dioxane-water, J. Pharm. Sci, 87, 1590, 10.1021\u002Fjs980149x",{"doi":1866},"10.1021\u002Fjs980149x",{"id":24,"text":1868,"url":24,"identifiers":1869},"FEDORS R. F, 1974, A method for estimating both the solubility parameters and molar volumes of liquids, Polym. Eng. Sci, 14, 147, 10.1002\u002Fpen.760140211",{"doi":1870},"10.1002\u002Fpen.760140211",{"id":24,"text":1872,"url":24,"identifiers":1873},"GARZÓN L. C, 2004, Temperature-solubility dependence for ibuprofen in some organic and aqueous solvents, J. Solution Chem, 33, 1379, 10.1007\u002Fs10953-004-1051-2",{"doi":1874},"10.1007\u002Fs10953-004-1051-2",{"id":24,"text":1876,"url":24,"identifiers":1877},"HANSEN J. M, 1967",{},{"id":24,"text":1879,"url":24,"identifiers":1880},"HILDEBRAND J. H, 1970",{},{"id":24,"text":1882,"url":24,"identifiers":1883},"KRISTL A, 1995, Thermodynamic investigation of the effect of octanol-water mutual miscibility on the partitioning and solubility of some guanine derivatives, J. Chem. Soc. Faraday Trans, 91, 995, 10.1039\u002FFT9959100995",{"doi":1884},"10.1039\u002FFT9959100995",{"id":24,"text":1886,"url":24,"identifiers":1887},"KRUG R. R, 1976, Enthalpy-entropy compensation: 2. Separation of the chemical from the statistical effects, J. Phys. Chem, 80, 2341, 10.1021\u002Fj100562a007",{"doi":1888},"10.1021\u002Fj100562a007",{"id":24,"text":1890,"url":24,"identifiers":1891},"MANRIQUE J, 2007, Solubility of ibuprofen in some ethanol + water cosolvent mixtures at several temperatures, Lat. Am. J. Pharm, 26, 344",{},{"id":24,"text":1893,"url":24,"identifiers":1894},"MANRIQUE Y. J, 2008, Thermodynamics of mixing and solvation of ibuprofen and naproxen in propylene glycol + water cosolvent mixtures, J. Solution Chem, 37, 165, 10.1007\u002Fs10953-007-9228-0",{"doi":1895},"10.1007\u002Fs10953-007-9228-0",{"id":24,"text":1897,"url":24,"identifiers":1898},"MARTIN A, 1989, El parámetro de solubilidad en las ciencias farmacéuticas, Anal. Real Acad. Farm, 55, 175",{},{"id":24,"text":1900,"url":24,"identifiers":1901},"MARTIN A, 1993, 4, 223",{},{"id":24,"text":1903,"url":24,"identifiers":1904},"PERLOVICH G. L, 2004, Thermodynamics of sublimation, crystal lattice energies, and crystal structures of racemates and enantiomers: (+)- and (+\u002F-)-ibuprofen, J. Pharm. Sci, 93, 654, 10.1002\u002Fjps.10586",{"doi":1905},"10.1002\u002Fjps.10586",{"id":24,"text":1907,"url":24,"identifiers":1908},"ROBERTS II L. J, 2001, Analgesic-antipyretic and anti-inflammatory agents and drugs employed in the treatment of gout, 10, 703",{},{"id":24,"text":1910,"url":24,"identifiers":1911},"ROSENSTEIN-STER E, 2004, 32, 553",{},{"id":24,"text":1913,"url":24,"identifiers":1914},"TEWES F, 2006, Biodegradable microspheres: Advances in production technology, 2, 1",{},{"id":24,"text":1916,"url":24,"identifiers":1917},"TRIANA M. T, 2009, Solution and mixing thermodynamics of propranolol and atenolol in aqueous media, J. Solution Chem, 38, 73, 10.1007\u002Fs10953-008-9348-1",{"doi":1918},"10.1007\u002Fs10953-008-9348-1",{"id":24,"text":1920,"url":24,"identifiers":1921},"1994, 785",{},{"id":1923,"createTime":1924,"updateTime":1924,"relativeEntities":1925,"slug":1926,"properties":1927,"entityType":134,"verifyStatus":135,"verifyTime":1924,"verifyNote":137,"syncStatus":23,"languages":1939,"translateLanguages":24,"viewCount":25,"primaryUrl":1940,"fullTextUrl":24,"authors":1941,"publicationType":201,"publisherRelationship":1999,"citationCount":109,"citationInfo":2035,"publishDate":2037,"publishYear":552,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":2038,"isForceReanalyzing":449},"23249a1a-de43-417a-965c-455899697c70","2024-08-31T03:48:18.218+00:00",[],"Analgesic-and-anti-inflammatory-activities-of-several-4-substituted-6-3-nitrophenyl-pyridazin-2H-3-one-derivatives",{"mag":1928,"keywords":1930,"openalex":1931,"abstract":1933,"title":1935,"doi":1937},{"VOID":1929},"2082331631",{},{"VOID":1932},"W2082331631",{"EN":1934},"\u003Cjats:p>Several 6-aryl-4-substituted benzylidene\u002Ffurfurylidene pyridazin(2H)-3-one derivatives (4a-f) were synthesized and evaluated as analgesic and anti-inflammatory agents in mice and rats, respectively. All compounds were tested by using Eddy's hot plate and the carrageenan-induced hind paw oedema method for the evaluation of analgesic and anti-inflammatory activities, respectively. Results showed that compounds 4f, 4b, 4d, and 4e exhibited higher analgesic and anti-inflammatory activities than other remaining compounds. All title compounds (4a-f) were characterized by IR, NMR and Mass spectroscopy.\u003C\u002Fjats:p>",{"EN":1936},"Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives",{"VOID":1938},"10.1590\u002Fs1984-82502013000400030",[139],"http:\u002F\u002Fwww.scielo.br\u002Fscielo.php?script=sci_arttext&pid=S1984-82502013000400030&lng=en&tlng=en",[1942,1963,1984],{"id":1943,"sortIndex":103,"researcher":24,"roles":1944,"affiliations":1945,"properties":1956},"edf67436-5ef4-4f2b-897c-e153a31cc6d9",[],[1946],{"id":1947,"sortIndex":25,"affiliation":1948,"properties":24},"9ce85a10-1878-4f91-9e8f-52bd4116f3de",{"id":1949,"createTime":1950,"updateTime":1950,"relativeEntities":1951,"slug":1952,"properties":1953,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"225ebcf3-9b0d-4dd8-bf5b-578f91133673","2024-08-31T03:48:18.239+00:00",[],"Kumaun-University-India",{"title":1954},{"EN":1955},"Kumaun University, India",{"openalex":1957,"orcid":1959,"title":1961},{"VOID":1958},"A5051179887",{"VOID":1960},"https:\u002F\u002Forcid.org\u002F0000-0002-9352-3462",{"EN":1962},"Mohammad Asif",{"id":1964,"sortIndex":25,"researcher":24,"roles":1965,"affiliations":1966,"properties":1977},"59c76437-4e1b-4813-a0dd-0e19a7cef372",[],[1967],{"id":1968,"sortIndex":25,"affiliation":1969,"properties":24},"c81d450e-575c-4c7b-9bd4-e27c63a2159e",{"id":1970,"createTime":1971,"updateTime":1971,"relativeEntities":1972,"slug":1973,"properties":1974,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"a1a6e91c-f053-4cb4-ba9a-ad8fb0f2068d","2024-08-31T03:48:18.228+00:00",[],"Institute-of-Management-and-Technology-India",{"title":1975},{"EN":1976},"Institute of Management and Technology, India",{"openalex":1978,"orcid":1980,"title":1982},{"VOID":1979},"A5101621069",{"VOID":1981},"https:\u002F\u002Forcid.org\u002F0000-0002-4693-7718",{"EN":1983},"Anita Singh",{"id":1985,"sortIndex":104,"researcher":24,"roles":1986,"affiliations":1987,"properties":1994},"c4145bf8-01c8-4ba5-bc7f-caf93a27d465",[],[1988],{"id":1989,"sortIndex":25,"affiliation":1990,"properties":24},"c43b7fac-6294-4aa6-a0e7-3b9a1ab05145",{"id":1949,"createTime":1950,"updateTime":1950,"relativeEntities":1991,"slug":1952,"properties":1992,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":1993},{"EN":1955},{"openalex":1995,"title":1997},{"VOID":1996},"A5084391136",{"EN":1998},"Lakshmayya",{"url":24,"publisher":2000,"properties":2030},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2001,"slug":10,"properties":2002,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":2008,"manageAffiliations":2009,"indexDatabases":2010,"url":96,"thumbnailPath":24,"statistic":2025,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":2003,"issn":2004,"introduce":2005,"eissn":2006,"title":2007},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[2011,2018],{"id":78,"indexDatabase":2012,"url":91,"indexYears":92,"academicFieldIds":2017,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":2013,"label":2014,"description":2015,"key":88,"publicationTags":2016,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"id":59,"indexDatabase":2019,"url":74,"indexYears":24,"academicFieldIds":2024,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":2020,"label":2021,"description":2022,"key":70,"publicationTags":2023,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"impactFactor":25,"impactFactorByYear":2026,"i10Index":100,"i10IndexLast5Year":25,"totalPublication":101,"totalPublicationByYear":2027,"totalCitation":105,"totalCitationByYear":2028,"totalCitationPerPublication":110,"totalCitationPerPublicationByYear":2029,"hindexLast5Year":100,"hindex":100},{"2012":99},{"2010":103,"2011":104,"2013":104},{"2010":107,"2011":108,"2013":109},{"2010":112,"2011":108,"2013":109},{"volume":2031,"pages":2032,"issue":2034},{"VOID":540},{"VOID":2033},"903-909",{"VOID":239},{"total":109,"publishYear":24,"statisticByYear":2036},{"2016":104,"2018":243,"2020":244,"2021":103,"2022":103,"2023":103,"2024":103},"2013-12-01",[2039,2042,2045,2049,2053,2056,2059,2063,2067,2071,2075,2079,2083,2086,2090,2093,2097,2100,2104,2108,2111,2114,2117,2121,2125],{"id":24,"text":2040,"url":24,"identifiers":2041},"ASIF M., 2011, LAKSHMAYYA Synthesis and anticonvulsant activity of 6-(3'-nitrophenyl)-4-substituted benzylidene-2, 3, 5-trihydro pyridazin-3-one, Middle-East J. Sci. Res., 9, 481",{},{"id":24,"text":2043,"url":24,"identifiers":2044},"BAYTAS S., 2012, Synthesis, anti-inflammatory, antiplatelet and in silico evaluations of (E)-3-(3-(2,3-dihydro-3-methyl-2-oxo-3H-benzoxazole-6-yl)-1-phenyl-1H-pyrazole-4-yl)acrylamides, Turk. J. Chem., 36, 367",{},{"id":24,"text":2046,"url":24,"identifiers":2047},"CHINTAKUNTA V.K., 2002, 3-O-subtituted benzyl pyridazinone derivatives as COX inhibitors, Eur. J. Med. Chem., 37, 339, 10.1016\u002FS0223-5234(02)01336-3",{"doi":2048},"10.1016\u002FS0223-5234(02)01336-3",{"id":24,"text":2050,"url":24,"identifiers":2051},"DOGRUER D.S., 2000, Studies on some 3(2H)-pyridazinone derivatives with antinociceptive activity, Arch. Pharm. Pharm. Med. Chem., 333, 79, 10.1002\u002F(SICI)1521-4184(20004)333:4\u003C79::AID-ARDP79>3.0.CO;2-S",{"doi":2052},"10.1002\u002F(SICI)1521-4184(20004)333:4\u003C79::AID-ARDP79>3.0.CO;2-S",{"id":24,"text":2054,"url":24,"identifiers":2055},"DOGRUER D.S., 2003, Synthesis and analgesic and anti-inflammatory activity of new pyridazinones, Turk. J. Chem., 27, 727",{},{"id":24,"text":2057,"url":24,"identifiers":2058},"DOGRUER D.S., 2007, Synthesis of 2-[5,6-diphenyl-3(2H)-pyridazinone-2-yl] acetamide and 3-[5,6-diphenyl-3(2H)-pyridazinone-2-yl]propanamide derivatives as Analgesic and anti-inflammatory agents, Turk. J. Pharm. Sci., 4, 57",{},{"id":24,"text":2060,"url":24,"identifiers":2061},"FLOUZAT C, 1993, Novel non opioid non antiinflammatory analgesics: 3-(aminoalkyl) and 3-[(4-aryl-1-piperazinyl) alkyl] oxazolo [4,5-b] pyridin-2(3H)ones, J. Med. Chem., 36, 497, 10.1021\u002Fjm00056a010",{"doi":2062},"10.1021\u002Fjm00056a010",{"id":24,"text":2064,"url":24,"identifiers":2065},"GIOVANNONI M.P., 2003, [(3-Chlorophenyl) piperazinylpropyl] pyridazinones and analogues as potent antinociceptive agents, J. Med. Chem., 46, 1055, 10.1021\u002Fjm021057u",{"doi":2066},"10.1021\u002Fjm021057u",{"id":24,"text":2068,"url":24,"identifiers":2069},"GOKCE M, 2001, Synthesis and antinociceptive activity of 6-substituted-3-pyridazinone derivatives, Farmaco, 56, 233, 10.1016\u002FS0014-827X(01)01037-0",{"doi":2070},"10.1016\u002FS0014-827X(01)01037-0",{"id":24,"text":2072,"url":24,"identifiers":2073},"HALLAS J., 1995, Nonsteroidal anti-inflammatory drugs and upper gastrointestinal bleeding, identifying high-risk groups by excess risk estimates, Scand. J. Gastroenterol, 30, 438, 10.3109\u002F00365529509093304",{"doi":2074},"10.3109\u002F00365529509093304",{"id":24,"text":2076,"url":24,"identifiers":2077},"HEINISCH G., 1990, Pharmacologically active pyridazine derivatives, Prog. Med. Chem, 27, 1, 10.1016\u002FS0079-6468(08)70288-1",{"doi":2078},"10.1016\u002FS0079-6468(08)70288-1",{"id":24,"text":2080,"url":24,"identifiers":2081},"JING T., 2007, Synthesis of 5-(6-Pyridazinone-3-yl)-2-lycosylamino-1,3,4-oxadiazoles, J. Chinese Chem. Soc., 54, 1287, 10.1002\u002Fjccs.200700181",{"doi":2082},"10.1002\u002Fjccs.200700181",{"id":24,"text":2084,"url":24,"identifiers":2085},"KULKARNI S.K, 1999, 3, 131",{},{"id":24,"text":2087,"url":24,"identifiers":2088},"MCCARTHY D, 1998, Nonsteroidal antiinflammatory drug-related gastrointestinal toxicity: definition and epidemiology, Am. J. Med., 105, 3S, 10.1016\u002FS0002-9343(98)00274-5",{"doi":2089},"10.1016\u002FS0002-9343(98)00274-5",{"id":24,"text":2091,"url":24,"identifiers":2092},"ISLAM M., 2008, Synthesis, antitubercular, antifungal and antibacterial activities of 6-Substituted Phenyl-2-(3'-Substituted Phenyl Pyridazin-6'-yl)-2,3,4,5-Tetrahydropyridazin-3-one., Acta Poloniae Pharm, 65, 353",{},{"id":24,"text":2094,"url":24,"identifiers":2095},"PIAZ V.D., 1996, 4,5-Functionalized-6-phenyl-3(2H)-pyridazinones: synthesis and evaluation of antinociceptive activity, Eur. J. Med. Chem., 31, 65, 10.1016\u002FS0223-5234(96)80008-0",{"doi":2096},"10.1016\u002FS0223-5234(96)80008-0",{"id":24,"text":2098,"url":24,"identifiers":2099},"PINNA G.A., 1992, Synthesis and pharmacologicalactivity of 4-carbamoyl-5-aryl-6-methyl-4,5-dihydropyridazin-3(2H)-ones, Farmaco, 47, 449",{},{"id":24,"text":2101,"url":24,"identifiers":2102},"RASKIN J.B, 1999, Gastrointestinal effects of nonsteroidal antiinflammatory therapy, Am. J. Med., 106, 3S, 10.1016\u002FS0002-9343(99)00112-6",{"doi":2103},"10.1016\u002FS0002-9343(99)00112-6",{"id":24,"text":2105,"url":24,"identifiers":2106},"RUBAT C., 1992, Synthesis of mannich bases of arylidenepyridazinones as analgesic agents, J. Pharm. Sci., 81, 1084, 10.1002\u002Fjps.2600811108",{"doi":2107},"10.1002\u002Fjps.2600811108",{"id":24,"text":2109,"url":24,"identifiers":2110},"SIDDIQUI A.A., 2004, Synthesis and hypotensive activity of some 6-(substituted aryl)-4-methyl-2,3-dihydropyridazin-3-ones, Indian J. Chem-B, 43B, 1574",{},{"id":24,"text":2112,"url":24,"identifiers":2113},"SIDDIQUI A.A., Synthesis and anticonvulsant activity of 6-(3'-nitrophenyl)-4-substituted benzylidene-2,3,5-trihydropyridazin-3-one, J. Ultrachem, 3, 173",{},{"id":24,"text":2115,"url":24,"identifiers":2116},"SUKUROGLU M., 2006, Synthesis and analgesic activity of some 4,6-disubstituted-3(2H)-pyridazinone derivatives, Arzneim. -Forsch, 56, 337",{},{"id":24,"text":2118,"url":24,"identifiers":2119},"TAKAYA M., 1979, New nonsteroidal analgesic antiinflammatory agent. Synthesis and activity of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone and related compounds, J. Med. Chem., 22, 53, 10.1021\u002Fjm00187a013",{"doi":2120},"10.1021\u002Fjm00187a013",{"id":24,"text":2122,"url":24,"identifiers":2123},"VAN J.R, 1995, New insights into the mode of action of antiinflammatory drugs, Inflamm. Res, 44, 1, 10.1007\u002FBF01630479",{"doi":2124},"10.1007\u002FBF01630479",{"id":24,"text":2126,"url":24,"identifiers":2127},"WINTER C.A., 1962, Carrageenan- iinduced oedema in hind paw of rat as an assay of anti-inflammatory drugs, Exp. Biol. Med., 111, 19, 10.3181\u002F00379727-111-27849",{"doi":2128},"10.3181\u002F00379727-111-27849",{"id":2130,"createTime":2131,"updateTime":2131,"relativeEntities":2132,"slug":2133,"properties":2134,"entityType":134,"verifyStatus":135,"verifyTime":2131,"verifyNote":137,"syncStatus":23,"languages":2146,"translateLanguages":24,"viewCount":25,"primaryUrl":2147,"fullTextUrl":24,"authors":2148,"publicationType":201,"publisherRelationship":2245,"citationCount":108,"citationInfo":2281,"publishDate":1248,"publishYear":1249,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":2283,"isForceReanalyzing":449},"7a8d23c2-f5ed-46c1-8f92-f53ba6d4acb8","2024-10-13T01:23:48.951+00:00",[],"Use-of-medicinal-herbs-by-patients-with-severe-asthma-managed-at-a-Referral-Center",{"mag":2135,"keywords":2137,"openalex":2138,"abstract":2140,"title":2142,"doi":2144},{"VOID":2136},"2028992265",{},{"VOID":2139},"W2028992265",{"EN":2141},"\u003Cjats:p>Asthma is a chronic inflammatory disease of the airways that may lead to limitations in regular activities, to hospitalizations and a decrease in quality of life. Adherence to drug treatment is crucial for control of the disease. The use of medicinal herbs can reduce adherence to prescriptions, as the medication may be replaced by infusions or herbal products. The objective of this study was to evaluate the frequency of use of traditional herbal medicine among severe asthmatics in Salvador. Information on use of homemade remedies was obtained through application of a questionnaire during patient visits to a referral center. We also collected data on economic and social aspects as well as disease control. One hundred and forty-four (91,1%) out of one hundred and fifty-eight patients evaluated used herbal medicines, but only 26.5% attributed improvement of asthma symptoms to this alternative treatment and only 8 had substituted a prescribed medication by herbal medicines. There was a trend towards lower adherence to prescription drug treatment in this group of patients. Despite the high frequency of use of medicinal herbs in our sample, there was no improvement in the asthma treatment in this population compared to non-users. Adherence to conventional drug treatment was satisfactory and there was neither reduction in asthma control nor increase in hospitalizations among the users of medicinal plants.\u003C\u002Fjats:p>",{"EN":2143},"Use of medicinal herbs by patients with severe asthma managed at a Referral Center",{"VOID":2145},"10.1590\u002Fs1984-82502011000300024",[139],"http:\u002F\u002Fwww.scielo.br\u002Fscielo.php?script=sci_arttext&pid=S1984-82502011000300024&lng=en&tlng=en",[2149,2169,2186,2207,2228],{"id":2150,"sortIndex":243,"researcher":24,"roles":2151,"affiliations":2152,"properties":2164},"71df6e9a-abf4-49a0-b679-9a63cdf2bd99",[],[2153],{"id":2154,"sortIndex":25,"affiliation":2155,"properties":24},"f6d82000-9efe-49dc-948c-9f5828eb90e6",{"id":2156,"createTime":2157,"updateTime":2158,"relativeEntities":2159,"slug":2160,"properties":2161,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"b41aee14-2a29-44bc-b404-7e5bb97c019b","2024-04-11T21:25:26.055+00:00","2024-10-13T01:23:48.972+00:00",[],"Federal-University-of-Bahia",{"title":2162},{"EN":2163},"Federal University of Bahia",{"openalex":2165,"title":2167},{"VOID":2166},"A5103457483",{"EN":2168},"Lúcia de Araújo Beisl Costa Noblat",{"id":2170,"sortIndex":25,"researcher":24,"roles":2171,"affiliations":2172,"properties":2179},"3e46a48d-83ba-4694-93b7-24b1a4df3948",[],[2173],{"id":2174,"sortIndex":25,"affiliation":2175,"properties":24},"35837fad-75a7-4d3b-9585-81b7de6b8ecf",{"id":2156,"createTime":2157,"updateTime":2158,"relativeEntities":2176,"slug":2160,"properties":2177,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2178},{"EN":2163},{"openalex":2180,"orcid":2182,"title":2184},{"VOID":2181},"A5000777415",{"VOID":2183},"https:\u002F\u002Forcid.org\u002F0000-0003-3301-6175",{"EN":2185},"Tacila ́Pires Mega",{"id":2187,"sortIndex":103,"researcher":24,"roles":2188,"affiliations":2189,"properties":2200},"7c06ebb7-ff2b-4c9c-8386-986612aecd05",[],[2190],{"id":2191,"sortIndex":25,"affiliation":2192,"properties":24},"a74e7c74-9246-4c25-a02c-d48a69c31055",{"id":2193,"createTime":2194,"updateTime":2194,"relativeEntities":2195,"slug":2196,"properties":2197,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"31bf5b35-4028-4d98-8f0f-61b345696063","2024-10-13T01:23:49.003+00:00",[],"Program-for-the-Control-of-Asthma-in-Bahia",{"title":2198},{"EN":2199},"Program for the Control of Asthma in Bahia",{"openalex":2201,"orcid":2203,"title":2205},{"VOID":2202},"A5046426560",{"VOID":2204},"https:\u002F\u002Forcid.org\u002F0000-0002-1475-2663",{"EN":2206},"Adelmir Souza‐Machado",{"id":2208,"sortIndex":104,"researcher":24,"roles":2209,"affiliations":2210,"properties":2221},"ff871f2d-cf1a-40b8-a87e-0b88e67da244",[],[2211],{"id":2212,"sortIndex":25,"affiliation":2213,"properties":24},"5f19fbdc-93e7-422f-b5e4-1450bb11cf99",{"id":2214,"createTime":2215,"updateTime":2215,"relativeEntities":2216,"slug":2217,"properties":2218,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},"9d944cc9-cc9a-4d10-b1a5-dbdbd87939ad","2024-10-13T01:23:48.986+00:00",[],"Federal-University-of-Bahia-Program-for-the-Control-of-Asthma-in-Bahia",{"title":2219},{"EN":2220},"Federal University of Bahia; Program for the Control of Asthma in Bahia",{"openalex":2222,"orcid":2224,"title":2226},{"VOID":2223},"A5036975027",{"VOID":2225},"https:\u002F\u002Forcid.org\u002F0000-0001-6821-0141",{"EN":2227},"P Moura Santos",{"id":2229,"sortIndex":100,"researcher":24,"roles":2230,"affiliations":2231,"properties":2238},"f9e4fcbe-a0d9-4b4d-a369-c9f5b34a1452",[],[2232],{"id":2233,"sortIndex":25,"affiliation":2234,"properties":24},"d16122b0-d421-4213-b362-198043f59689",{"id":2193,"createTime":2194,"updateTime":2194,"relativeEntities":2235,"slug":2196,"properties":2236,"entityType":45,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":2237},{"EN":2199},{"openalex":2239,"orcid":2241,"title":2243},{"VOID":2240},"A5063051968",{"VOID":2242},"https:\u002F\u002Forcid.org\u002F0000-0002-7403-3871",{"EN":2244},"Álvaro A. Cruz",{"url":24,"publisher":2246,"properties":2276},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":2247,"slug":10,"properties":2248,"entityType":22,"verifyStatus":23,"verifyTime":24,"verifyNote":24,"syncStatus":23,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":2254,"manageAffiliations":2255,"indexDatabases":2256,"url":96,"thumbnailPath":24,"statistic":2271,"gsStatistic":24,"type":24,"analyzePriority":24},[],{"country":2249,"issn":2250,"introduce":2251,"eissn":2252,"title":2253},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":19},{"EN":21},[],[],[2257,2264],{"id":78,"indexDatabase":2258,"url":91,"indexYears":92,"academicFieldIds":2263,"indexDatabaseRanking":95},{"id":80,"createTime":81,"updateTime":82,"relativeEntities":2259,"label":2260,"description":2261,"key":88,"publicationTags":2262,"standard":24},[],{"EN":85,"VI":85},{"EN":85,"VI":87},[90],[94],{"id":59,"indexDatabase":2265,"url":74,"indexYears":24,"academicFieldIds":2270,"indexDatabaseRanking":24},{"id":61,"createTime":62,"updateTime":63,"relativeEntities":2266,"label":2267,"description":2268,"key":70,"publicationTags":2269,"standard":24},[],{"EN":66,"VI":66},{"VI":68,"EN":69},[72,73],[76],{"impactFactor":25,"impactFactorByYear":2272,"i10Index":100,"i10IndexLast5Year":25,"totalPublication":101,"totalPublicationByYear":2273,"totalCitation":105,"totalCitationByYear":2274,"totalCitationPerPublication":110,"totalCitationPerPublicationByYear":2275,"hindexLast5Year":100,"hindex":100},{"2012":99},{"2010":103,"2011":104,"2013":104},{"2010":107,"2011":108,"2013":109},{"2010":112,"2011":108,"2013":109},{"volume":2277,"pages":2278,"issue":2280},{"VOID":1241},{"VOID":2279},"643-649",{"VOID":768},{"total":108,"publishYear":24,"statisticByYear":2282},{"2012":104,"2017":104,"2019":104,"2020":243,"2021":104,"2023":243,"2024":104},[2284,2288,2291,2294,2298,2301,2305,2309,2313,2317,2320,2323,2326,2330,2332,2335,2337,2341,2345,2348,2351,2355,2358,2362,2366,2370,2373,2377,2381,2385,2388,2391,2395,2399,2401,2404],{"id":24,"text":2285,"url":24,"identifiers":2286},"ABUHAMDAH S., 2008, Pharmacological profile of an essential oil derived from Melissa officinalis with anti-agitation properties: focus on ligand-gated channels, J. Pharm. Pharmacol., 60, 377, 10.1211\u002Fjpp.60.3.0014",{"doi":2287},"10.1211\u002Fjpp.60.3.0014",{"id":24,"text":2289,"url":24,"identifiers":2290},"AGRA M. F., 2008, Survey of medicinal plants used in the region Northeast of Brazil, Braz J. Pharmacogn., 18",{},{"id":24,"text":2292,"url":24,"identifiers":2293},"ALMEIDA M. Z., 2003, 2",{},{"id":24,"text":2295,"url":24,"identifiers":2296},"ASHER M. I., 2006, Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys, Lancet, 368, 733, 10.1016\u002FS0140-6736(06)69283-0",{"doi":2297},"10.1016\u002FS0140-6736(06)69283-0",{"id":24,"text":2299,"url":24,"identifiers":2300},"",{},{"id":24,"text":2302,"url":24,"identifiers":2303},"BARNES J., 2003, Quality, efficacy and safety of complementary medicines: Fashins, facts and future: Part II: efficacy and safety, Br. J. Clin. Pharmacol., 55, 331, 10.1046\u002Fj.1365-2125.2003.01811.x",{"doi":2304},"10.1046\u002Fj.1365-2125.2003.01811.x",{"id":24,"text":2306,"url":24,"identifiers":2307},"BLANC P. D., 1997, Use of herbal products, coffee or black tea, and over-the-counter medications as self-treatments among adults with asthma, J. Allergy Clin. Immunol., 100, 789, 10.1016\u002FS0091-6749(97)70275-6",{"doi":2308},"10.1016\u002FS0091-6749(97)70275-6",{"id":24,"text":2310,"url":24,"identifiers":2311},"BLANC P. D., 2001, Alternatives teraphies among adults with reported diagnosis of asthma or rhinosinusitis: data from a population-based survey, Chest, 120, 1461, 10.1378\u002Fchest.120.5.1461",{"doi":2312},"10.1378\u002Fchest.120.5.1461",{"id":24,"text":2314,"url":24,"identifiers":2315},"CARVAJAL-URUENA I., 2005, Geographic variation in the prevalence of asthma symptoms in Spanish children and adolescents: International Study of Asthma and Allergies in Childhood (ISAAC) Phase 3, Spain, Arch. Bronconeumol., 41, 659, 10.1016\u002FS1579-2129(06)60333-9",{"doi":2316},"10.1016\u002FS1579-2129(06)60333-9",{"id":24,"text":2318,"url":24,"identifiers":2319},"CLEMENT Y. N., 2005, Medicinal herb use among asthmatic patients attending a specialty care facility in Trinidad, BMC Complement. Altern. Med., 5, 12",{},{"id":24,"text":2321,"url":24,"identifiers":2322},"CORRÊA M. P., 1984",{},{"id":24,"text":2324,"url":24,"identifiers":2325},"CRUZ G. L., 1995, 5",{},{"id":24,"text":2327,"url":24,"identifiers":2328},"ERNST E., 1998, Complementary therapies for asthma: what patients use, J. Asthma,, 35, 667, 10.3109\u002F02770909809048969",{"doi":2329},"10.3109\u002F02770909809048969",{"id":24,"text":2299,"url":24,"identifiers":2331},{},{"id":24,"text":2333,"url":24,"identifiers":2334},"FRANCO R., 2007, Cost-effectiveness analysis of a state funded program for control of severe asthma, BMC Public Health (online), 7",{},{"id":24,"text":1140,"url":24,"identifiers":2336},{},{"id":24,"text":2338,"url":24,"identifiers":2339},"JOSE V. M., 2007, Study of association between use of complementary and alternative medicine and non-compliance with modern medicine in patients presenting to the emergency department, J. Postgrad. Med., 53, 96, 10.4103\u002F0022-3859.32208",{"doi":2340},"10.4103\u002F0022-3859.32208",{"id":24,"text":2342,"url":24,"identifiers":2343},"JUNIPER E. F., 1999, Development and validation of a questionnaire to measure asthma control, Eur. Respir. J., 14, 902, 10.1034\u002Fj.1399-3003.1999.14d29.x",{"doi":2344},"10.1034\u002Fj.1399-3003.1999.14d29.x",{"id":24,"text":2346,"url":24,"identifiers":2347},"LAINETTI R., 1979",{},{"id":24,"text":2349,"url":24,"identifiers":2350},"LEITE M., 2008, Evaluation of the asthma control questionnaire validated for use in Brazil, J. Bras. Pneumol., 34, 756",{},{"id":24,"text":2352,"url":24,"identifiers":2353},"MCKAY D. L., 2006, A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.), Phytother. Res., 20, 519, 10.1002\u002Fptr.1900",{"doi":2354},"10.1002\u002Fptr.1900",{"id":24,"text":2356,"url":24,"identifiers":2357},"MOREIRA R. C. T., 2002, Abordagem etnobotância acerca do uso de plantas medicinais na Vila Cachoeira, Ihéus, Bahia, Brasil, Acta Farm. Bonaerense, 21, 205",{},{"id":24,"text":2359,"url":24,"identifiers":2360},"NG T. P., 2003, The use of complementary and alternative medicine by asthma patients, QJM, 96, 747, 10.1093\u002Fqjmed\u002Fhcg121",{"doi":2361},"10.1093\u002Fqjmed\u002Fhcg121",{"id":24,"text":2363,"url":24,"identifiers":2364},"PARTRIDGE M. R., 2003, The use of complementary medicine by those with asthma, Respir. Med., 97, 436, 10.1053\u002Frmed.2002.1403",{"doi":2365},"10.1053\u002Frmed.2002.1403",{"id":24,"text":2367,"url":24,"identifiers":2368},"PINTO E. P. P., 2006, Conhecimento popular sobre plantas medicinais em comunidades rurais de mata atlântica- Itacaré, BA, Brasil, Acta Bot. Bras., 20, 751, 10.1590\u002FS0102-33062006000400001",{"doi":2369},"10.1590\u002FS0102-33062006000400001",{"id":24,"text":2371,"url":24,"identifiers":2372},"SANTOS P. M., 2008, Predictors of adherence to treatment in patients with severe asthma treated at a referral center in Bahia, Brazil, J. Bras. Pneumol., 12, 995",{},{"id":24,"text":2374,"url":24,"identifiers":2375},"SHAW A., 2008, Predictors of complementary therapy use among asthma patients: results of a primary care survey, Health Soc. Care Community., 16, 155, 10.1111\u002Fj.1365-2524.2007.00738.x",{"doi":2376},"10.1111\u002Fj.1365-2524.2007.00738.x",{"id":24,"text":2378,"url":24,"identifiers":2379},"SINGH V., 2002, Barriers in the management of asthma and attitudes towards complementary medicine, Respir. Med., 96, 835, 10.1053\u002Frmed.2002.1368",{"doi":2380},"10.1053\u002Frmed.2002.1368",{"id":24,"text":2382,"url":24,"identifiers":2383},"SLADER C. A., 2006, Complementary and alternative medicine use in asthma: Who is using what?, Respirology, 11, 373, 10.1111\u002Fj.1440-1843.2006.00861.x",{"doi":2384},"10.1111\u002Fj.1440-1843.2006.00861.x",{"id":24,"text":2386,"url":24,"identifiers":2387},"2006, IV Diretrizes Brasileiras para o manejo da Asma, J. Bras. Pneumol., 32, S447",{},{"id":24,"text":2389,"url":24,"identifiers":2390},"SOLÉ D., 2006, Prevalence of symptoms of asthma, rhinitis, and atopic eczema among Brazilian children and adolescents identified by the International Study of Asthma and Allergies in Childhood (ISAAC)- Phase 3, J. Pediatr., 82, 341",{},{"id":24,"text":2392,"url":24,"identifiers":2393},"SZELENYI I., 2002, Herbal remedies for asthma treatment: between myth and reality, Drugs Today, 38, 265, 10.1358\u002Fdot.2002.38.4.668337",{"doi":2394},"10.1358\u002Fdot.2002.38.4.668337",{"id":24,"text":2396,"url":24,"identifiers":2397},"TIRAPELLI C. R., 2007, Antispasmodic and relaxant effects of the hidroalcoholic extract of Pimpinella anisum (Apiaceae) on rat anococcygeus smooth muscle, J. Ethnopharmarcol., 110, 23, 10.1016\u002Fj.jep.2006.08.031",{"doi":2398},"10.1016\u002Fj.jep.2006.08.031",{"id":24,"text":2299,"url":24,"identifiers":2400},{},{"id":24,"text":2402,"url":24,"identifiers":2403},"2007",{},{"id":24,"text":2405,"url":24,"identifiers":2406},"YAN D. C., 2005, Prevalence and severity of symptoms of asthma, rhinitis, and eczema in 13- to 14-year-old children in Taipei, Taiwan, Ann. Allergy, Asthma Immun., 95, 579, 10.1016\u002FS1081-1206(10)61022-8",{"doi":2407},"10.1016\u002FS1081-1206(10)61022-8"]