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isolated from the cancellous bone of the rabbit femur, J Orthop Res, 19, 391, 10.1016\u002FS0736-0266(00)90026-3\nDeckers, 2000, Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation, Endocrinology, 141, 1667, 10.1210\u002Fen.141.5.1667\nChikazu, 2000, Fibroblast growth factor (FGF)-2 directly stimulates mature osteoclast function through activation of FGF receptor 1 and p42\u002Fp44 MAP kinase, J Biol Chem, 275, 31444, 10.1074\u002Fjbc.M910132199\nLiang, 1999, Bone anabolic effects of basic fibroblast growth factor in ovariectomized rats, Endocrinology, 140, 5780, 10.1210\u002Fen.140.12.5780\nHyder, 2000, Regulation of vascular endothelial growth factor expression by estrogens and progestins, Environ Health Perspect, 108, 785, 10.2307\u002F3454307\nReynolds, 1998, Time-course of the uterine response to estradiol-17beta in ovariectomized ewes, Biol Reprod, 59, 613, 10.1095\u002Fbiolreprod59.3.613\nGalbiati, 2001, Hypothalamic transforming growth factor beta1 and basic fibroblast growth factor mRNA expression is modified during the rat oestrous cycle, J Neuroendocrinol, 13, 483, 10.1046\u002Fj.1365-2826.2001.00659.x\nThompson, 1997, Long-term estradiol replacement decreases contractility of guinea pig coronary arteries to the thromboxane mimetic U46619, Circulation, 95, 709, 10.1161\u002F01.CIR.95.3.709\nMacRitchie, 1997, Estrogen upregulates endothelial nitric oxide synthase gene expression in fetal pulmonary artery endothelium, Circ Res, 81, 355, 10.1161\u002F01.RES.81.3.355\nBinko, 1998, 17 beta-oestradiol enhances nitric oxide synthase activity in endothelium-denuded rat aorta, Clin Exp Pharmacol Physiol, 25, 120, 10.1111\u002Fj.1440-1681.1998.tb02188.x\nWimalawansa, 1996, Nitric oxide donor alleviates ovariectomy-induced bone loss, Bone, 8, 301, 10.1016\u002F8756-3282(96)00005-1\nArmour, 2001, Inhibition of bone resorption in vitro and prevention of ovariectomy-induced bone loss in vivo by flurbiprofen 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