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other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. 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         \u003Cjats:p>Although measurements of crystallinity index (CI) have a long history, it has been found that CI varies significantly depending on the choice of measurement method. In this study, four different techniques incorporating X-ray diffraction and solid-state \u003Cjats:sup>13\u003C\u002Fjats:sup>C nuclear magnetic resonance (NMR) were compared using eight different cellulose preparations. We found that the simplest method, which is also the most widely used, and which involves measurement of just two heights in the X-ray diffractogram, produced significantly higher crystallinity values than did the other methods. Data in the literature for the cellulose preparation used (Avicel PH-101) support this observation. We believe that the alternative X-ray diffraction (XRD) and NMR methods presented here, which consider the contributions from amorphous and crystalline cellulose to the entire XRD and NMR spectra, provide a more accurate measure of the crystallinity of cellulose. Although celluloses having a high amorphous content are usually more easily digested by enzymes, it is unclear, based on studies published in the literature, whether CI actually provides a clear indication of the digestibility of a cellulose sample. Cellulose accessibility should be affected by crystallinity, but is also likely to be affected by several other parameters, such as lignin\u002Fhemicellulose contents and distribution, porosity, and particle size. Given the methodological dependency of cellulose CI values and the complex nature of cellulase interactions with amorphous and crystalline celluloses, we caution against trying to correlate relatively small changes in CI with changes in cellulose digestibility. In addition, the prediction of cellulase performance based on low levels of cellulose conversion may not include sufficient digestion of the crystalline component to be meaningful.\u003C\u002Fjats:p>","Mặc dù chỉ số tinh thể (CI) đã được đo lường từ lâu, nhưng đã phát hiện ra rằng CI thay đổi đáng kể tùy thuộc vào phương pháp đo được chọn. Trong nghiên cứu này, bốn kỹ thuật khác nhau kết hợp nhiễu xạ tia X và cộng hưởng từ hạt nhân carbon-13 rắn (NMR) đã được so sánh bằng cách sử dụng tám chế phẩm cellulose khác nhau. Chúng tôi nhận thấy rằng phương pháp đơn giản nhất, cũng là phương pháp phổ biến nhất, liên quan đến việc đo chỉ hai độ cao trong phổ nhiễu xạ tia X, đã tạo ra giá trị độ tinh thể cao hơn đáng kể so với các phương pháp khác. Dữ liệu trong tài liệu về chế phẩm cellulose đã sử dụng (Avicel PH-101) hỗ trợ cho nhận định này. Chúng tôi tin rằng các phương pháp XRD và NMR thay thế được trình bày ở đây, mà xem xét các đóng góp từ cellulose vô định hình và tinh thể vào toàn bộ phổ XRD và NMR, cung cấp một phép đo chính xác hơn về độ tinh thể của cellulose. Mặc dù cellulose có hàm lượng vô định hình cao thường dễ bị vi sinh vật phân hủy hơn, nhưng không rõ ràng, dựa trên các nghiên cứu được công bố trong tài liệu, liệu CI có thực sự cung cấp chỉ số rõ ràng về khả năng tiêu hóa của một mẫu cellulose hay không. Khả năng tiếp cận cellulose nên bị ảnh hưởng bởi độ tinh thể, nhưng cũng có khả năng bị ảnh hưởng bởi một số thông số khác, chẳng hạn như hàm lượng và phân bố lignin\u002Fhemicellulose, độ xốp và kích thước hạt. Với sự phụ thuộc vào phương pháp đo CI cellulose và bản chất phức tạp của sự tương tác của cellulase với cellulose vô định hình và tinh thể, chúng tôi cảnh báo không nên cố gắng tương quan những thay đổi tương đối nhỏ trong CI với những thay đổi trong khả năng tiêu hóa cellulose. Ngoài ra, dự đoán hiệu suất của cellulase dựa trên các mức chuyển đổi cellulose thấp có thể không bao gồm đủ sự tiêu hóa của thành phần tinh thể để có ý nghĩa.",{"EN":819,"VI":820},"Cellulose crystallinity index: measurement techniques and their impact on interpreting cellulase performance","Chỉ số tinh thể của cellulose: các kỹ thuật đo đạc và tác động của chúng đến việc diễn giải hiệu suất của cellulase",{"VOID":822},"20497524",{"VOID":824},"10.1186\u002F1754-6834-3-10","PUBLICATION","Auto Verify",[102],[101],"https:\u002F\u002Fbiotechnologyforbiofuels.biomedcentral.com\u002Farticles\u002F10.1186\u002F1754-6834-3-10",[831,849,865,881,901],{"id":832,"sortIndex":114,"researcher":26,"roles":833,"affiliations":834,"properties":844},"1c174a79-ed0d-4d6c-9cc6-a2f799a400db",[],[835],{"id":26,"sortIndex":36,"affiliation":836,"properties":26},{"id":837,"createTime":838,"updateTime":838,"relativeEntities":839,"slug":840,"properties":841,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"38a0845f-3311-4b70-86f5-a6e38401444c","2024-04-15T12:49:56.024+00:00",[],"Biosciences-Center-National-Renewable-Energy-Laboratory-1617-Cole-Blvd-Golden-CO-80401-USA",{"title":842},{"EN":843},"Biosciences Center, National Renewable Energy Laboratory, 1617 Cole Blvd Golden, CO, 80401, USA",{"openalex":845,"title":847},{"VOID":846},"A5006644300",{"EN":848},"Michael E. 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J Polym Sci Polym Lett 1975, 13: 23-27. 10.1002\u002Fpol.1975.130130104",{"doi":954},"10.1002\u002Fpol.1975.130130104",{"id":26,"text":956,"url":26,"identifiers":957},"Gardiner ES, Sarko A: Packing analysis of carbohydrates and polysaccharides. 16. The crystal-structures of cellulose IV\n                    1\n                  and cellulose IV\n                    11\n                  . Can J Chem 1985, 63: 173-180. 10.1139\u002Fv85-027",{"doi":958},"10.1139\u002Fv85-027",{"id":26,"text":960,"url":26,"identifiers":961},"Pérez S, Mazeau K: Conformations, structures, and morphologies of celluloses. In Polysaccharides: Structural diversity and functional versatility. 2nd edition. Edited by: S. Dumitriu. Marcel Dekker; 2005.",{},{"id":26,"text":963,"url":26,"identifiers":964},"O'Sullivan A: Cellulose: the structure slowly unravel. 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Science 1984, 223: 283-285. 10.1126\u002Fscience.223.4633.283",{"doi":981},"10.1126\u002Fscience.223.4633.283",{"id":26,"text":983,"url":26,"identifiers":984},"Nisizawa K: Mode of action of cellulases. J Ferment Technol 1973, 51: 267-304.",{},{"id":26,"text":986,"url":26,"identifiers":987},"Åkerholm M, Hinterstoisser B, Salmén L: Characterization of the crystalline structure of cellulose using static and dynamic FT-IR spectroscopy. Carbohydr Res 2004, 339: 569-578. 10.1016\u002Fj.carres.2003.11.012",{"doi":988},"10.1016\u002Fj.carres.2003.11.012",{"id":26,"text":990,"url":26,"identifiers":991},"Evans R, Newman RH, Roick UC: Changes in cellulose crystallinity during kraft pulping. Comparison of infrared, x-ray diffraction and solid state NMR results. 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J Wood Chem Tech 1986, 6: 1-14. 10.1080\u002F02773818608085213",{"doi":1224},"10.1080\u002F02773818608085213",false,{"id":1227,"createTime":1228,"updateTime":1229,"relativeEntities":1230,"slug":1231,"properties":1232,"entityType":825,"verifyStatus":25,"verifyTime":1228,"verifyNote":826,"syncStatus":28,"languages":1250,"translateLanguages":1251,"viewCount":36,"primaryUrl":1252,"fullTextUrl":26,"authors":1253,"publicationType":915,"publisherRelationship":1393,"citationCount":1420,"citationInfo":1421,"publishDate":948,"publishYear":949,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":1423,"isForceReanalyzing":1225},"aebf49f7-4611-4a6a-a546-efee31a95cd2","2024-11-25T20:54:01.329+00:00","2025-02-16T02:51:45.533+00:00",[],"Furfural-induces-reactive-oxygen-species-accumulation-and-cellular-damage-in-Saccharomyces-cerevisiae",{"mag":1233,"keywords":1235,"pmc":1236,"openalex":1238,"abstract":1240,"title":1243,"pm":1246,"doi":1248},{"VOID":1234},"2140485535",{"VI":810},{"VOID":1237},"2820483",{"VOID":1239},"W2140485535",{"EN":1241,"VI":1242},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>Biofuels offer a viable alternative to petroleum-based fuel. However, current methods are not sufficient and the technology required in order to use lignocellulosic biomass as a fermentation substrate faces several challenges. One challenge is the need for a robust fermentative microorganism that can tolerate the inhibitors present during lignocellulosic fermentation. These inhibitors include the furan aldehyde, furfural, which is released as a byproduct of pentose dehydration during the weak acid pretreatment of lignocellulose. In order to survive in the presence of furfural, yeast cells need not only to reduce furfural to the less toxic furan methanol, but also to protect themselves and repair any damage caused by the furfural. Since furfural tolerance in yeast requires a functional pentose phosphate pathway (PPP), and the PPP is associated with reactive oxygen species (ROS) tolerance, we decided to investigate whether or not furfural induces ROS and its related cellular damage in yeast.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>We demonstrated that furfural induces the accumulation of ROS in \u003Cjats:italic>Saccharomyces cerevisiae\u003C\u002Fjats:italic>. In addition, furfural was shown to cause cellular damage that is consistent with ROS accumulation in cells which includes damage to mitochondria and vacuole membranes, the actin cytoskeleton and nuclear chromatin. The furfural-induced damage is less severe when yeast are grown in a furfural concentration (25 m\u003Cjats:italic>M\u003C\u002Fjats:italic>) that allows for eventual growth after an extended lag compared to a concentration of furfural (50 m\u003Cjats:italic>M\u003C\u002Fjats:italic>) that prevents growth.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusion\u003C\u002Fjats:title>\n            \u003Cjats:p>These data suggest that when yeast cells encounter the inhibitor furfural, they not only need to reduce furfural into furan methanol but also to protect themselves from the cellular effects of furfural and repair any damage caused. The reduced cellular damage seen at 25 m\u003Cjats:italic>M\u003C\u002Fjats:italic> furfural compared to 50 m\u003Cjats:italic>M\u003C\u002Fjats:italic> furfural may be linked to the observation that at 25 m\u003Cjats:italic>M\u003C\u002Fjats:italic> furfural yeast were able to exit the furfural-induced lag phase and resume growth. Understanding the cellular effects of furfural will help direct future strain development to engineer strains capable of tolerating or remediating ROS and the effects of ROS.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Đặt vấn đề\u003C\u002Fjats:title>\n            \u003Cjats:p>Sinh khối sinh học cung cấp một lựa chọn khả thi thay thế cho nhiên liệu dựa trên dầu mỏ. Tuy nhiên, các phương pháp hiện tại chưa đủ hiệu quả và công nghệ cần thiết để sử dụng sinh khối lignocellulosic như một nền tảng lên men gặp nhiều thách thức. Một trong những thách thức là cần có một vi sinh vật lên men mạnh mẽ có khả năng chịu đựng các chất ức chế có mặt trong quá trình lên men lignocellulosic. Những chất ức chế này bao gồm furan aldehyde, furfural, được giải phóng như một sản phẩm phụ của sự khử nước pentose trong quá trình xử lý axit yếu của lignocellulose. Để tồn tại trong môi trường có mặt furan, các tế bào nấm men không chỉ cần giảm furfural thành furan methanol ít độc hại hơn mà còn phải tự bảo vệ và sửa chữa bất kỳ tổn thương nào do furfural gây ra. Vì khả năng chịu đựng furfural ở nấm men yêu cầu một con đường phốt phát pentose (PPP) hoạt động, và PPP liên quan đến khả năng chịu đựng các loài oxy phản ứng (ROS), chúng tôi quyết định điều tra liệu furfural có kích thích ROS và tổn thương tế bào liên quan hay không ở nấm men.",{"EN":1244,"VI":1245},"Furfural induces reactive oxygen species accumulation and cellular damage in Saccharomyces cerevisiae","Furfural gây ra sự tích lũy các loài oxy phản ứng và tổn thương tế bào ở Saccharomyces cerevisiae",{"VOID":1247},"20150993",{"VOID":1249},"10.1186\u002F1754-6834-3-2",[102],[101],"https:\u002F\u002Fbiotechnologyforbiofuels.biomedcentral.com\u002Farticles\u002F10.1186\u002F1754-6834-3-2",[1254,1273,1293,1310,1331,1346,1361,1376],{"id":1255,"sortIndex":162,"researcher":26,"roles":1256,"affiliations":1257,"properties":1268},"ffb3fe03-3454-43ea-b132-6960066598e8",[],[1258],{"id":1259,"sortIndex":36,"affiliation":1260,"properties":26},"281ea824-dfd3-4172-b172-93035a1c3eb9",{"id":1261,"createTime":1262,"updateTime":1262,"relativeEntities":1263,"slug":1264,"properties":1265,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"d6bb173c-2a84-4997-8b86-e8931c932d7b","2024-11-25T20:54:01.363+00:00",[],"Agricultural-Research-Service-United-States-Department-of-Agriculture-National-Center-for-Agricultural-Utilization-Research-Peoria-USA",{"title":1266},{"EN":1267},"Agricultural Research Service, United States Department of Agriculture, National Center for Agricultural Utilization Research, Peoria, USA",{"openalex":1269,"title":1271},{"VOID":1270},"A5111528510",{"EN":1272},"Patricia J. 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         \u003Cjats:sec>\n            \u003Cjats:title>Background\u003C\u002Fjats:title>\n            \u003Cjats:p>Second-generation biofuels are generally produced from the polysaccharides in the lignocellulosic plant biomass, mainly cellulose. However, because cellulose is embedded in a matrix of other polysaccharides and lignin, its hydrolysis into the fermentable glucose is hampered. The senesced inflorescence stems of a set of 20 \u003Cjats:italic>Arabidopsis thaliana\u003C\u002Fjats:italic> mutants in 10 different genes of the lignin biosynthetic pathway were analyzed for cell wall composition and saccharification yield. Saccharification models were built to elucidate which cell wall parameters played a role in cell wall recalcitrance.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Results\u003C\u002Fjats:title>\n            \u003Cjats:p>Although lignin is a key polymer providing the strength necessary for the plant’s ability to grow upward, a reduction in lignin content down to 64% of the wild-type level in \u003Cjats:italic>Arabidopsis\u003C\u002Fjats:italic> was tolerated without any obvious growth penalty. In contrast to common perception, we found that a reduction in lignin was not compensated for by an increase in cellulose, but rather by an increase in matrix polysaccharides. In most lignin mutants, the saccharification yield was improved by up to 88% cellulose conversion for the \u003Cjats:italic>cinnamoyl-coenzyme A reductase1\u003C\u002Fjats:italic> mutants under pretreatment conditions, whereas the wild-type cellulose conversion only reached 18%. The saccharification models and Pearson correlation matrix revealed that the lignin content was the main factor determining the saccharification yield. However, also lignin composition, matrix polysaccharide content and composition, and, especially, the xylose, galactose, and arabinose contents influenced the saccharification yield. Strikingly, cellulose content did not significantly affect saccharification yield.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Conclusions\u003C\u002Fjats:title>\n            \u003Cjats:p>Although the lignin content had the main effect on saccharification, also other cell wall factors could be engineered to potentially increase the cell wall processability, such as the galactose content. Our results contribute to a better understanding of the effect of lignin perturbations on plant cell wall composition and its influence on saccharification yield, and provide new potential targets for genetic improvement.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\n          \u003Cjats:sec>\n            \u003Cjats:title>Nền tảng\u003C\u002Fjats:title>\n            \u003Cjats:p>Các nhiên liệu sinh học thế hệ thứ hai thường được sản xuất từ các polysaccharide trong sinh khối thực vật lignocellulosic, chủ yếu là cellulose. Tuy nhiên, vì cellulose được nhúng trong một ma trận các polysaccharide khác và lignin, việc thủy phân cellulose thành glucose có thể lên men bị cản trở. Các thân hoa đã già của một tập hợp 20 đột biến \u003Cjats:italic>Arabidopsis thaliana\u003C\u002Fjats:italic> ở 10 gen khác nhau của con đường tổng hợp lignin đã được phân tích để xác định thành phần tế bào và năng suất saccharification. Các mô hình saccharification đã được xây dựng để làm rõ các tham số tường tế bào nào đã góp phần vào tính khó khăn trong tường tế bào.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết quả\u003C\u002Fjats:title>\n            \u003Cjats:p>Mặc dù lignin là một polymer chính cung cấp sức mạnh cần thiết cho khả năng phát triển lên của cây, nhưng việc giảm hàm lượng lignin xuống còn 64% mức tự nhiên ở \u003Cjats:italic>Arabidopsis\u003C\u002Fjats:italic> vẫn được dung nạp mà không có bất kỳ hình phạt nào cho sự phát triển. Trái ngược với quan niệm thông thường, chúng tôi phát hiện ra rằng việc giảm lignin không được bù đắp bởi việc tăng cellulose, mà là bởi việc tăng các polysaccharide trong ma trận. Ở hầu hết các đột biến lignin, năng suất saccharification được cải thiện với tỷ lệ chuyển đổi cellulose đạt tới 88% cho các đột biến \u003Cjats:italic>cinnamoyl-coenzyme A reductase1\u003C\u002Fjats:italic> trong điều kiện xử lý trước, trong khi tỷ lệ chuyển đổi cellulose của loại hoang dã chỉ đạt 18%. Các mô hình saccharification và ma trận tương quan Pearson đã chỉ ra rằng hàm lượng lignin là yếu tố chính xác định năng suất saccharification. Tuy nhiên, cả thành phần lignin, hàm lượng và thành phần polysaccharide ma trận, đặc biệt là hàm lượng xylose, galactose và arabinose cũng ảnh hưởng đến năng suất saccharification. Đáng chú ý, hàm lượng cellulose không ảnh hưởng đáng kể đến năng suất saccharification.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>\n          \u003Cjats:sec>\n            \u003Cjats:title>Kết luận\u003C\u002Fjats:title>\n            \u003Cjats:p>Mặc dù hàm lượng lignin có ảnh hưởng chính đến saccharification, nhưng cũng có thể kỹ thuật hóa các yếu tố tường tế bào khác để có khả năng tăng cường tính khả dụng của tường, chẳng hạn như hàm lượng galactose. Các kết quả của chúng tôi đóng góp vào việc hiểu rõ hơn về tác động của các rối loạn lignin đến thành phần tường tế bào thực vật và sự ảnh hưởng của nó đến năng suất saccharification, đồng thời cung cấp các mục tiêu tiềm năng mới cho việc cải tiến di truyền.\u003C\u002Fjats:p>\n          \u003C\u002Fjats:sec>",{"EN":2806,"VI":2807},"Lignin biosynthesis perturbations affect secondary cell wall composition and saccharification yield in Arabidopsis thaliana","Sự rối loạn trong tổng hợp lignin ảnh hưởng đến thành phần dãy tế bào thứ cấp và năng suất saccharification ở Arabidopsis thaliana",{"VOID":2809},"23622268",{"VOID":2811},"10.1186\u002F1754-6834-6-46","2024-12-18T13:37:27.876+00:00",[102],[101],"https:\u002F\u002Fbiotechnologyforbiofuels.biomedcentral.com\u002Farticles\u002F10.1186\u002F1754-6834-6-46",[2817,2837,2858,2873,2894,2911],{"id":2818,"sortIndex":59,"researcher":26,"roles":2819,"affiliations":2820,"properties":2830},"b06791ca-0ca3-4979-86ed-533a3df7e404",[],[2821],{"id":2822,"sortIndex":36,"affiliation":2823,"properties":26},"bd074293-5ea2-41a5-855d-90b5b94bb329",{"id":2824,"createTime":2825,"updateTime":2825,"relativeEntities":2826,"slug":26,"properties":2827,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"88471065-c781-4452-8a59-09f500398118","2023-12-06T05:27:45.536+00:00",[],{"title":2828},{"VI":2829},"Department of Biochemistry, Cambridge University, Cambridge, CB2 1QW, United Kingdom",{"openalex":2831,"orcid":2833,"title":2835},{"VOID":2832},"A5010898155",{"VOID":2834},"https:\u002F\u002Forcid.org\u002F0000-0001-6624-636X",{"EN":2836},"Jenny C. 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H, Nandakumar R, Wang Z-Y: Genetic modification of lignin biosynthesis for improved biofuel production. In Vitro Cell Dev Biol-Plant. 2009, 45: 306-313. 10.1007\u002Fs11627-009-9219-5.",{"doi":2963},"10.1007\u002Fs11627-009-9219-5",{"id":26,"text":2965,"url":26,"identifiers":2966},"Yuan JS, Tiller KH, Al-Ahmad H, Stewart NR, Stewart NC: Plants to power: bioenergy to fuel the future. Trends Plant Sci. 2008, 13: 421-429. 10.1016\u002Fj.tplants.2008.06.001.",{"doi":2967},"10.1016\u002Fj.tplants.2008.06.001",{"id":26,"text":2969,"url":26,"identifiers":2970},"Chen F, Dixon RA: Lignin modification improves fermentable sugar yields for biofuel production. Nat Biotechnol. 2007, 25: 759-761. 10.1038\u002Fnbt1316.",{"doi":2971},"10.1038\u002Fnbt1316",{"id":26,"text":2973,"url":26,"identifiers":2974},"Endler A, Persson S: Cellulose synthases and synthesis in Arabidopsis. 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Biotechniques. 2003;34(2):374.",{"doi":3731},"10.2144\u002F03342mt01",{"id":3733,"createTime":3734,"updateTime":3735,"relativeEntities":3736,"slug":3737,"properties":3738,"entityType":825,"verifyStatus":25,"verifyTime":3735,"verifyNote":826,"syncStatus":28,"languages":3756,"translateLanguages":3757,"viewCount":36,"primaryUrl":3758,"fullTextUrl":26,"authors":3759,"publicationType":915,"publisherRelationship":3851,"citationCount":3873,"citationInfo":3874,"publishDate":3876,"publishYear":3877,"citationAnalyzeStatus":3878,"lastCitationAnalyze":3879,"indexDatabases":26,"openAccess":26,"references":3880,"isForceReanalyzing":1225},"0c4b37f4-6f60-4b65-b55d-1a62ee4393c2","2024-04-12T03:20:22.577+00:00","2025-02-27T01:52:13.390+00:00",[],"Parallel-metatranscriptome-analyses-of-host-and-symbiont-gene-expression-in-the-gut-of-the-termite-Reticulitermes-flavipes",{"mag":3739,"keywords":3741,"pmc":3742,"openalex":3744,"abstract":3746,"title":3749,"pm":3752,"doi":3754},{"VOID":3740},"2134578745",{"VI":810},{"VOID":3743},"2768689",{"VOID":3745},"W2134578745",{"EN":3747,"VI":3748},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Background\u003C\u002Fjats:title>\u003Cjats:p>Termite lignocellulose digestion is achieved through a collaboration of host plus prokaryotic and eukaryotic symbionts. In the present work, we took a combined host and symbiont metatranscriptomic approach for investigating the digestive contributions of host and symbiont in the lower termite\u003Cjats:italic>Reticulitermes flavipes\u003C\u002Fjats:italic>. Our approach consisted of parallel high-throughput sequencing from (i) a host gut cDNA library and (ii) a hindgut symbiont cDNA library. Subsequently, we undertook functional analyses of newly identified phenoloxidases with potential importance as pretreatment enzymes in industrial lignocellulose processing.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Over 10,000 expressed sequence tags (ESTs) were sequenced from the 2 libraries that aligned into 6,555 putative transcripts, including 171 putative lignocellulase genes. Sequence analyses provided insights in two areas. First, a non-overlapping complement of host and symbiont (prokaryotic plus protist) glycohydrolase gene families known to participate in cellulose, hemicellulose, alpha carbohydrate, and chitin degradation were identified. Of these, cellulases are contributed by host plus symbiont genomes, whereas hemicellulases are contributed exclusively by symbiont genomes. Second, a diverse complement of previously unknown genes that encode proteins with homology to lignase, antioxidant, and detoxification enzymes were identified exclusively from the host library (laccase, catalase, peroxidase, superoxide dismutase, carboxylesterase, cytochrome P450). Subsequently, functional analyses of phenoloxidase activity provided results that were strongly consistent with patterns of laccase gene expression. In particular, phenoloxidase activity and laccase gene expression are mostly restricted to symbiont-free foregut plus salivary gland tissues, and phenoloxidase activity is inducible by lignin feeding.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusion\u003C\u002Fjats:title>\u003Cjats:p>To our knowledge, this is the first time that a dual host-symbiont transcriptome sequencing effort has been conducted in a single termite species. This sequence database represents an important new genomic resource for use in further studies of collaborative host-symbiont termite digestion, as well as development of coevolved host and symbiont-derived biocatalysts for use in industrial biomass-to-bioethanol applications. Additionally, this study demonstrates that: (i) phenoloxidase activities are prominent in the\u003Cjats:italic>R. flavipes\u003C\u002Fjats:italic>gut and are not symbiont derived, (ii) expands the known number of host and symbiont glycosyl hydrolase families in\u003Cjats:italic>Reticulitermes\u003C\u002Fjats:italic>, and (iii) supports previous models of lignin degradation and host-symbiont collaboration in cellulose\u002Fhemicellulose digestion in the termite gut. All sequences in this paper are available publicly with the accession numbers FL634956-FL640828 (Termite Gut library) and FL641015-FL645753 (Symbiont library).\u003C\u002Fjats:p>\u003C\u002Fjats:sec>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Nền tảng\u003C\u002Fjats:title>\u003Cjats:p>Việc tiêu hóa lignocellulose trong mối được thực hiện thông qua sự hợp tác giữa vật chủ và các sinh vật cộng sinh prokaryote cùng eukaryote. Trong công trình hiện tại, chúng tôi đã áp dụng phương pháp metatranscriptomic kết hợp giữa vật chủ và sinh vật cộng sinh để điều tra những đóng góp trong tiêu hóa của vật chủ và sinh vật cộng sinh ở loài mối dưới \u003Cjats:italic>Reticulitermes flavipes\u003C\u002Fjats:italic>. Phương pháp của chúng tôi bao gồm việc giải trình tự đồng thời ở quy mô lớn từ (i) thư viện cDNA của ruột vật chủ và (ii) thư viện cDNA của sinh vật cộng sinh ở ruột sau. Sau đó, chúng tôi đã tiến hành phân tích chức năng của các phenoloxidase vừa được xác định với tầm quan trọng tiềm năng như là enzyme xử lý trước trong quy trình lignocellulose công nghiệp.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Kết quả\u003C\u002Fjats:title>\u003Cjats:p>Hơn 10.000 đoạn trình tự biểu hiện (EST) đã được giải mã từ 2 thư viện, trong đó tương ứng với 6.555 bản sao tiềm năng, bao gồm 171 gen lignocellulase tiềm năng. Phân tích trình tự đã cung cấp những hiểu biết ở hai lĩnh vực. Thứ nhất, một tập hợp bổ sung không chồng chéo của các gia đình gen glycohydrolase ở vật chủ và sinh vật cộng sinh (bao gồm prokaryote và protist) đã được xác định, được biết đến với việc tham gia vào sự phân hủy cellulose, hemicellulose, carbohydrate alpha và chitin. Trong số này, cellulose được đóng góp bởi cả gen vật chủ và sinh vật cộng sinh, trong khi hemicellulase chỉ được đóng góp bởi gen sinh vật cộng sinh. Thứ hai, một tập hợp đa dạng của các gen chưa được biết đến trước đó mã hóa các protein có tính tương đồng với lignase, enzyme chống oxy hóa và enzyme giải độc đã được xác định độc quyền từ thư viện vật chủ (laccase, catalase, peroxidase, superoxide dismutase, carboxylesterase, cytochrome P450). Tiếp theo, phân tích chức năng của hoạt động phenoloxidase đã cung cấp kết quả tương ứng chặt chẽ với các mẫu biểu hiện gen laccase. Cụ thể, hoạt động phenoloxidase và biểu hiện gen laccase chủ yếu được giới hạn ở các mô không có sinh vật cộng sinh ở ruột trước và tuyến nước bọt, và hoạt động phenoloxidase có thể được kích thích bởi việc cung cấp lignin.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Kết luận\u003C\u002Fjats:title>\u003Cjats:p>Chúng tôi cho rằng đây là lần đầu tiên một nỗ lực giải trình tự transcriptome kép ở vật chủ và sinh vật cộng sinh được thực hiện trong một loài mối duy nhất. Cơ sở dữ liệu trình tự này đại diện cho một nguồn tài nguyên gen mới quan trọng cho các nghiên cứu tiếp theo về tiêu hóa hợp tác của vật chủ-sinh vật cộng sinh trong mối, cũng như phát triển các chất xúc tác sinh học có nguồn gốc từ vật chủ và sinh vật cộng sinh đã cùng tiến hóa để sử dụng trong các ứng dụng công nghiệp biến đổi sinh khối thành bioethanol. Ngoài ra, nghiên cứu này cho thấy: (i) hoạt động phenoloxidase nổi bật trong ruột \u003Cjats:italic>R. flavipes\u003C\u002Fjats:italic> và không xuất phát từ sinh vật cộng sinh, (ii) mở rộng số lượng các gia đình glycosyl hydrolase đã biết của vật chủ và sinh vật cộng sinh trong \u003Cjats:italic>Reticulitermes\u003C\u002Fjats:italic>, và (iii) củng cố các mô hình trước đó về sự phân hủy lignin và sự hợp tác giữa vật chủ-сinh vật cộng sinh trong tiêu hóa cellulose\u002Fhemicellulose trong ruột mối. Tất cả các trình tự trong bài báo này đều có sẵn công khai với các số đăng ký FL634956-FL640828 (thư viện ruột mối) và FL641015-FL645753 (thư viện sinh vật cộng sinh).\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":3750,"VI":3751},"Parallel metatranscriptome analyses of host and symbiont gene expression in the gut of the termite Reticulitermes flavipes","Phân tích metatranscriptome song song về biểu hiện gen của vật chủ và sinh vật cộng sinh trong ruột của loài mối Reticulitermes flavipes",{"VOID":3753},"19832970",{"VOID":3755},"10.1186\u002F1754-6834-2-25",[102],[101],"https:\u002F\u002Fbiotechnologyforbiofuels.biomedcentral.com\u002Farticles\u002F10.1186\u002F1754-6834-2-25",[3760,3777,3793,3807,3823,3837],{"id":3761,"sortIndex":59,"researcher":26,"roles":3762,"affiliations":3763,"properties":3772},"b62740f2-3f93-4431-9bbd-9295aa1e33bc",[],[3764],{"id":26,"sortIndex":36,"affiliation":3765,"properties":26},{"id":3766,"createTime":3767,"updateTime":3767,"relativeEntities":3768,"slug":26,"properties":3769,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"0fa38871-e7b0-4a33-bb7b-80b735c1c1c5","2023-11-30T06:03:03.927+00:00",[],{"title":3770},{"VI":3771},"Department of Entomology and Nematology, University of Florida, Gainesville, FL, USA",{"openalex":3773,"title":3775},{"VOID":3774},"A5002598257",{"EN":3776},"Monique R. 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