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Journal of Medicine and Pharmacy","Tạp chí Y Dược học Cần Thơ",{"EN":487,"VI":488},"\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">04\u002F10\u002F2015 Ministry of Information and Communications allowed Can Tho journal of medicine and pharmacy to operate (102 \u002FGP-BTTTT)\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">07\u002F16\u002F2015 Can Tho journal of medicine and pharmacy is internationally recognized: ISSN 2354-1210\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">In 2016, The journal has been included in the list of medical science journals by The State Council for professorship which is awarded a work score of 0-0.5 points for a published article.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Can Tho Journal of Medicine and Pharmacy welcome original works that haven’t been submitted or published in other medical journals. Posts must contain content related to one of the journal’s categories.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The content published\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The journal is divided into 3 categories:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Scientific research article: are valuable scientific works, which have been researched and accepted.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Overview of medicine, biology and pharmacy: serving the objective of continuing training in the fields of medicine, biology and pharmacy; to systematize classical and modern knowledge.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Update information on new knowledge about medicine, biology, pharmacy in the country and in the world.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Scope\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Publication and introduction of scientific research in the fields:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Medicine (internal medicine, surgery, pediatrics, obstetrics and gynecology, odonto-stomatology, laboratory, oncology, traditional medicine, nursing).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Biology (genetics, biotechnology).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">+ Pharmacology (pharmaceutics, drug quality analysis-control, synthetic pharmaceutical chemistry, biochemistry, pharmacognosy, botany, clinical pharmacy).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- To enhance the quality of undergraduate, postgraduate education, scientifically researching and meet the necessary treatment in hospital.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Introducing the updated domestic and oversea information about science technology to promote scientific research and exchanging technology in local, other universities.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">- Exchanging pharmaceutical and medical information for social health developing in the Mekong Delta and Vietnam.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">The object\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Postgraduate students, student of Can Tho University of Medicine and Pharmacy, scientists from schools, research institutes, hospitals, health centers, pharmaceutical companies of the Mekong Delta; other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. Danh sách bài báo theo số Tạp chí được in ấn và phát hành trong năm định kỳ được công bố chính thức trên website: https:\u002F\u002Ftapchi.ctump.edu.vn\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",{"VOID":490},"wcQ1uqwAAAAJ","2023-05-30T08:17:21.868+00:00",[],[494],{"id":495,"createTime":28,"updateTime":28,"relativeEntities":496,"slug":28,"properties":497,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":507,"parentIds":508,"statistic":28},"6413896b-eca9-442b-a73f-182a58a0ce40",[],{"title":498,"address":501,"country":504,"abbreviation":505},{"EN":499,"VI":500},"Can Tho University of Medicine and Pharmacy","Trường Đại học Y Dược Cần Thơ",{"EN":502,"VI":503},"No 179, Nguyen Van Cu street, An Khanh ward, Ninh Kieu district, Can Tho city, Vietnam","Số 179, đường Nguyễn Văn Cừ, phường An Khánh, quận Ninh Kiều, thành phố Cần Thơ, Việt Nam",{"VOID":15},{"VOID":506},"ctump","http:\u002F\u002Fwww.ctump.edu.vn\u002F",[],[],"https:\u002F\u002Ftapchi.ctump.edu.vn\u002Findex.php\u002Fctump",{"impactFactor":32,"impactFactorByYear":512,"i10Index":32,"i10IndexLast5Year":32,"totalPublication":514,"totalPublicationByYear":515,"totalCitation":520,"totalCitationByYear":521,"totalCitationPerPublication":108,"totalCitationPerPublicationByYear":523,"hindexLast5Year":45,"hindex":45},{"2022":513,"2023":111,"2024":106},0.01,1556,{"2020":47,"2021":516,"2022":517,"2023":518,"2024":519,"2025":122},57,306,801,358,161,{"2021":146,"2022":280,"2023":522},99,{"2021":524,"2022":318,"2023":104},0.23,{"impactFactor":28,"impactFactorByYear":28,"i10Index":123,"i10IndexLast5Year":123,"totalPublication":526,"totalPublicationByYear":527,"totalCitation":526,"totalCitationByYear":528,"totalCitationPerPublication":40,"totalCitationPerPublicationByYear":531,"hindexLast5Year":49,"hindex":49},476,{"0":205,"2019":123,"2021":139,"2022":459,"2023":451,"2024":357,"2025":49,"2026":48},{"2021":42,"2022":123,"2023":161,"2024":529,"2025":360,"2026":530},136,83,{"2021":105,"2022":513,"2023":532,"2024":127,"2025":533,"2026":534},0.62,25.43,13.83,{"id":536,"createTime":537,"updateTime":382,"relativeEntities":538,"slug":539,"properties":540,"entityType":25,"verifyStatus":26,"verifyTime":28,"verifyNote":28,"languages":552,"translateLanguages":28,"viewCount":133,"subjectFields":553,"manageAffiliations":554,"indexDatabases":555,"url":556,"thumbnailPath":557,"statistic":558,"gsStatistic":594,"type":55,"analyzePriority":28},"6984a56a-db70-403b-9cc4-4013e1ceaffa","2023-05-09T06:47:40.346+00:00",[],"T%E1%BA%A1p%20ch%C3%AD%20Nghi%C3%AAn%20c%E1%BB%A9u%20n%C6%B0%E1%BB%9Bc%20ngo%C3%A0i",{"country":541,"issn":542,"title":544,"introduce":547,"gsId":550},{"VOID":15},{"VOID":543},"25252445",{"EN":545,"VI":546},"VNU Journal of Foreign Studies","Tạp chí Nghiên cứu nước ngoài",{"EN":548,"VI":549},"{\"ops\":[{\"insert\":\"\\n\\nThe \\n\"},{\"attributes\":{\"italic\":true},\"insert\":\"VNU Journal of Science\"},{\"insert\":\"\\n was established in 1985 for the publication of national and international research papers in all fields of natural sciences and technology, social sciences and humanities. 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Zentralb. (Leipzig), 13, 579",{},{"id":28,"text":1273,"url":28,"identifiers":1274},"Alzheimer, 1907, Uber eine eigenartige Erkrankung der Hirnrinde, Allg Zeits Psychiatry Psych. Med., 64, 146",{},{"id":28,"text":1276,"url":28,"identifiers":1277},"Jucker, M., Beyreuther, K., Haass, C., Nitsch, R., and Christen, Y. (2006). Alzheimer: 100 Years and Beyond, Springer.",{"doi":1278},"10.1007\u002F978-3-540-37652-1",{"id":28,"text":1280,"url":28,"identifiers":1281},"Kidd, 1963, Paired helical filaments in electron microscopy of Alzheimer’s disease, Nature, 197, 192, 10.1038\u002F197192b0",{"doi":1282},"10.1038\u002F197192b0",{"id":28,"text":1284,"url":28,"identifiers":1285},"Terry, 1963, The fine structure of neurofibrillary tangles in Alzheimer’s disease, J. Neuropathol. Exp. Neurol., 22, 629, 10.1097\u002F00005072-196310000-00005",{"doi":1286},"10.1097\u002F00005072-196310000-00005",{"id":28,"text":1288,"url":28,"identifiers":1289},"Crowther, 1985, Image reconstruction of the Alzheimer paired helical filament, EMBO J., 4, 3661, 10.1002\u002Fj.1460-2075.1985.tb04132.x",{"doi":1290},"10.1002\u002Fj.1460-2075.1985.tb04132.x",{"id":28,"text":1292,"url":28,"identifiers":1293},"Wischik, 1985, Subunit structure of paired helical filaments in Alzheimer’s disease, J. Cell Biol., 100, 1905, 10.1083\u002Fjcb.100.6.1905",{"doi":1294},"10.1083\u002Fjcb.100.6.1905",{"id":28,"text":1296,"url":28,"identifiers":1297},"Crowther, 1991, Straight and paired helical filaments in Alzheimer disease have a common structural unit, Proc. Natl. Acad. Sci. USA, 88, 2288, 10.1073\u002Fpnas.88.6.2288",{"doi":1298},"10.1073\u002Fpnas.88.6.2288",{"id":28,"text":1300,"url":28,"identifiers":1301},"Weingarten, 1975, A protein factor essential for microtubule assembly, Proc. Natl. Acad. Sci. USA, 72, 1858, 10.1073\u002Fpnas.72.5.1858",{"doi":1302},"10.1073\u002Fpnas.72.5.1858",{"id":28,"text":1304,"url":28,"identifiers":1305},"Cleveland, 1977, Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin, J. Mol. Biol., 116, 207, 10.1016\u002F0022-2836(77)90213-3",{"doi":1306},"10.1016\u002F0022-2836(77)90213-3",{"id":28,"text":1308,"url":28,"identifiers":1309},"Cleveland, 1977, Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly, J. Mol. Biol., 116, 227, 10.1016\u002F0022-2836(77)90214-5",{"doi":1310},"10.1016\u002F0022-2836(77)90214-5",{"id":28,"text":1312,"url":28,"identifiers":1313},"Pierre, 1983, Multisite phosphorylation of tau proteins from rat brain, Biochem. Biophys. Res. Commun., 115, 212, 10.1016\u002F0006-291X(83)90991-9",{"doi":1314},"10.1016\u002F0006-291X(83)90991-9",{"id":28,"text":1316,"url":28,"identifiers":1317},"Jameson, 1980, Inhibition of microtubule assembly by phosphorylation of microtubule-associated proteins, Biochemistry, 19, 2472, 10.1021\u002Fbi00552a027",{"doi":1318},"10.1021\u002Fbi00552a027",{"id":28,"text":1320,"url":28,"identifiers":1321},"Lindwall, 1984, Phosphorylation affects the ability of tau protein to promote microtubule assembly, J. Biol. Chem., 259, 5301, 10.1016\u002FS0021-9258(17)42989-9",{"doi":1322},"10.1016\u002FS0021-9258(17)42989-9",{"id":28,"text":1324,"url":28,"identifiers":1325},"Binder, 1985, The distribution of tau in the mammalian central nervous system, J. Cell Biol., 101, 1371, 10.1083\u002Fjcb.101.4.1371",{"doi":1326},"10.1083\u002Fjcb.101.4.1371",{"id":28,"text":1328,"url":28,"identifiers":1329},"Papasozomenos, 1987, Phosphorylation determines two distinct species of Tau in the central nervous system, Cell Motil. Cytoskeleton, 8, 210, 10.1002\u002Fcm.970080303",{"doi":1330},"10.1002\u002Fcm.970080303",{"id":28,"text":1332,"url":28,"identifiers":1333},"Migheli, 1988, Light and electron microscope localization of the microtubule-associated tau protein in rat brain, J. Neurosci., 8, 1846, 10.1523\u002FJNEUROSCI.08-06-01846.1988",{"doi":1334},"10.1523\u002FJNEUROSCI.08-06-01846.1988",{"id":28,"text":1336,"url":28,"identifiers":1337},"Couchie, 1988, Expression of the mRNA for tau proteins during brain development and in cultured neurons and astroglial cells, J. Neurochem., 50, 1894, 10.1111\u002Fj.1471-4159.1988.tb02494.x",{"doi":1338},"10.1111\u002Fj.1471-4159.1988.tb02494.x",{"id":28,"text":1340,"url":28,"identifiers":1341},"Brion, 1985, Mise en évidence immunologique de la protéine tau au niveau des lésions de dégénérescence neurofibrillaire de la maladie d’Alzheimer, Arch. Biol., 95, 229",{},{"id":28,"text":1343,"url":28,"identifiers":1344},"Anderton, 1982, Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants, Nature, 298, 84, 10.1038\u002F298084a0",{"doi":1345},"10.1038\u002F298084a0",{"id":28,"text":1347,"url":28,"identifiers":1348},"Iqbal, 1986, Microtubule-associated protein tau. A component of Alzheimer paired helical filaments, J. Biol. Chem., 261, 6084, 10.1016\u002FS0021-9258(17)38495-8",{"doi":1349},"10.1016\u002FS0021-9258(17)38495-8",{"id":28,"text":1351,"url":28,"identifiers":1352},"Iqbal, 1986, Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology, Proc. Natl. Acad. Sci. USA, 83, 4913, 10.1073\u002Fpnas.83.13.4913",{"doi":1353},"10.1073\u002Fpnas.83.13.4913",{"id":28,"text":1355,"url":28,"identifiers":1356},"Ihara, 1986, Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer’s disease, J. Biochem., 99, 1807, 10.1093\u002Foxfordjournals.jbchem.a135662",{"doi":1357},"10.1093\u002Foxfordjournals.jbchem.a135662",{"id":28,"text":1359,"url":28,"identifiers":1360},"Masters, 1985, Amyloid plaque core protein in Alzheimer disease and Down syndrome, Proc. Natl. Acad. Sci. USA, 82, 4245, 10.1073\u002Fpnas.82.12.4245",{"doi":1361},"10.1073\u002Fpnas.82.12.4245",{"id":28,"text":1363,"url":28,"identifiers":1364},"Masters, 1985, Neuronal origin of a cerebral amyloid: Neurofibrillary tangles of Alzheimer’s disease contain the same protein as the amyloid of plaque cores and blood vessels, EMBO J., 4, 2757, 10.1002\u002Fj.1460-2075.1985.tb04000.x",{"doi":1365},"10.1002\u002Fj.1460-2075.1985.tb04000.x",{"id":28,"text":1367,"url":28,"identifiers":1368},"Mori, 1987, Ubiquitin is a component of paired helical filaments in Alzheimer’s disease, Science, 235, 1641, 10.1126\u002Fscience.3029875",{"doi":1369},"10.1126\u002Fscience.3029875",{"id":28,"text":1371,"url":28,"identifiers":1372},"Perry, 1987, Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains, Proc. Natl. Acad. Sci. USA, 84, 3033, 10.1073\u002Fpnas.84.9.3033",{"doi":1373},"10.1073\u002Fpnas.84.9.3033",{"id":28,"text":1375,"url":28,"identifiers":1376},"Yen, 1983, Neurofibrillary tangles in senile dementia of the Alzheimer type share an antigenic determinant with intermediate filaments of the vimentin class, Am. J. Pathol., 113, 373",{},{"id":28,"text":1378,"url":28,"identifiers":1379},"Yen, 1987, Alzheimer’s neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP2, Am. J. Pathol., 126, 81",{},{"id":28,"text":1381,"url":28,"identifiers":1382},"Wischik, 1988, Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease, Proc. Natl. Acad. Sci. USA, 85, 4506, 10.1073\u002Fpnas.85.12.4506",{"doi":1383},"10.1073\u002Fpnas.85.12.4506",{"id":28,"text":1385,"url":28,"identifiers":1386},"Wischik, 1988, Structural characterization of the core of the paired helical filament of Alzheimer disease, Proc. Natl. Acad. Sci. USA, 85, 4884, 10.1073\u002Fpnas.85.13.4884",{"doi":1387},"10.1073\u002Fpnas.85.13.4884",{"id":28,"text":1389,"url":28,"identifiers":1390},"Novak, 1989, Characterisation of the first monoclonal antibody against the pronase resistant core of the Alzheimer PHF, Prog. Clin. Biol. Res., 317, 755",{},{"id":28,"text":1392,"url":28,"identifiers":1393},"Novak, 1991, Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51, Proc. Natl. Acad. Sci. USA, 88, 5837, 10.1073\u002Fpnas.88.13.5837",{"doi":1394},"10.1073\u002Fpnas.88.13.5837",{"id":28,"text":1396,"url":28,"identifiers":1397},"Resch, 1991, Design and synthesis of a potential affinity\u002Fcleaving reagent for beta-pleated sheet protein structures, Bioorg. Med. Chem. Lett., 1, 519, 10.1016\u002FS0960-894X(01)80457-1",{"doi":1398},"10.1016\u002FS0960-894X(01)80457-1",{"id":28,"text":1400,"url":28,"identifiers":1401},"Lee, 1988, The primary structure and heterogeneity of tau protein from mouse brain, Science, 239, 285, 10.1126\u002Fscience.3122323",{"doi":1402},"10.1126\u002Fscience.3122323",{"id":28,"text":1404,"url":28,"identifiers":1405},"Goedert, 1988, Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: Identification as the microtubule-associated protein tau, Proc. Natl. Acad. Sci. USA, 85, 4051, 10.1073\u002Fpnas.85.11.4051",{"doi":1406},"10.1073\u002Fpnas.85.11.4051",{"id":28,"text":1408,"url":28,"identifiers":1409},"Delacourte, 1986, Alzheimer’s disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments, J. Neurol. Sci., 76, 173, 10.1016\u002F0022-510X(86)90167-X",{"doi":1410},"10.1016\u002F0022-510X(86)90167-X",{"id":28,"text":1412,"url":28,"identifiers":1413},"Kosik, 1986, Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease, Proc. Natl. Acad. Sci. USA, 83, 4044, 10.1073\u002Fpnas.83.11.4044",{"doi":1414},"10.1073\u002Fpnas.83.11.4044",{"id":28,"text":1416,"url":28,"identifiers":1417},"Nukina, 1986, One of the antigenic determinants of paired helical filaments is related to tau protein, J. Biochem., 99, 1541, 10.1093\u002Foxfordjournals.jbchem.a135625",{"doi":1418},"10.1093\u002Foxfordjournals.jbchem.a135625",{"id":28,"text":1420,"url":28,"identifiers":1421},"Wood, 1986, Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau), Proc. Natl. Acad. Sci. USA, 83, 4040, 10.1073\u002Fpnas.83.11.4040",{"doi":1422},"10.1073\u002Fpnas.83.11.4040",{"id":28,"text":1424,"url":28,"identifiers":1425},"Serrano, 1986, Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease, Biochem. Biophys. Res. Commun., 141, 790, 10.1016\u002FS0006-291X(86)80242-X",{"doi":1426},"10.1016\u002FS0006-291X(86)80242-X",{"id":28,"text":1428,"url":28,"identifiers":1429},"Neve, 1986, Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2, Mol. Brain Res., 1, 271, 10.1016\u002F0169-328X(86)90033-1",{"doi":1430},"10.1016\u002F0169-328X(86)90033-1",{"id":28,"text":1432,"url":28,"identifiers":1433},"Donlon, 1987, Localization of microtubule-associated protein tau (MTBT1) to chromosome 17q21 (Abstract), Cytogenet. Cell Genet., 46, 607",{},{"id":28,"text":1435,"url":28,"identifiers":1436},"Goedert, 1989, Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: Differential expression of tau protein mRNAs in human brain, EMBO J., 8, 393, 10.1002\u002Fj.1460-2075.1989.tb03390.x",{"doi":1437},"10.1002\u002Fj.1460-2075.1989.tb03390.x",{"id":28,"text":1439,"url":28,"identifiers":1440},"Goedert, 1989, Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer’s disease, Neuron, 3, 519, 10.1016\u002F0896-6273(89)90210-9",{"doi":1441},"10.1016\u002F0896-6273(89)90210-9",{"id":28,"text":1443,"url":28,"identifiers":1444},"Goedert, 1990, Expression of separate isoforms of human tau protein: Correlation with the tau pattern in brain and effects on tubulin polymerization, EMBO J., 9, 4225, 10.1002\u002Fj.1460-2075.1990.tb07870.x",{"doi":1445},"10.1002\u002Fj.1460-2075.1990.tb07870.x",{"id":28,"text":1447,"url":28,"identifiers":1448},"Goedert, 1992, Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system, Proc. Natl. Acad. Sci. USA, 89, 1983, 10.1073\u002Fpnas.89.5.1983",{"doi":1449},"10.1073\u002Fpnas.89.5.1983",{"id":28,"text":1451,"url":28,"identifiers":1452},"Sedmak, 2012, Human fetal tau protein isoform: Possibilities for Alzheimer’s disease treatment, Int. J. Biochem. Cell Biol., 44, 1290, 10.1016\u002Fj.biocel.2012.05.001",{"doi":1453},"10.1016\u002Fj.biocel.2012.05.001",{"id":28,"text":1455,"url":28,"identifiers":1456},"Greenberg, 1990, A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis, Proc. Natl. Acad. Sci. USA, 87, 5827, 10.1073\u002Fpnas.87.15.5827",{"doi":1457},"10.1073\u002Fpnas.87.15.5827",{"id":28,"text":1459,"url":28,"identifiers":1460},"Mulot, 1994, PHF-tau from Alzheimer’s brain comprises four species on SDS-PAGE which can be mimicked by in vitro phosphorylation of human brain tau by glycogen synthase kinase-3 beta, FEBS Lett., 349, 359, 10.1016\u002F0014-5793(94)00702-0",{"doi":1461},"10.1016\u002F0014-5793(94)00702-0",{"id":28,"text":1463,"url":28,"identifiers":1464},"Wolozin, 1986, A neuronal antigen in the brains of Alzheimer patients, Science, 232, 648, 10.1126\u002Fscience.3083509",{"doi":1465},"10.1126\u002Fscience.3083509",{"id":28,"text":1467,"url":28,"identifiers":1468},"Flament, 1989, Abnormal tau species are produced during Alzheimer’s disease neurodegenerating process, FEBS Lett., 247, 213, 10.1016\u002F0014-5793(89)81337-7",{"doi":1469},"10.1016\u002F0014-5793(89)81337-7",{"id":28,"text":1471,"url":28,"identifiers":1472},"Lee, 1991, A68: A major subunit of paired helical filaments and derivatized forms of normal Tau, Science, 251, 675, 10.1126\u002Fscience.1899488",{"doi":1473},"10.1126\u002Fscience.1899488",{"id":28,"text":1475,"url":28,"identifiers":1476},"Lai, 1995, Examination of phosphorylated tau protein as a PHF-precursor at early stage Alzheimer’s disease, Neurobiol. Aging, 16, 433, 10.1016\u002F0197-4580(95)00041-C",{"doi":1477},"10.1016\u002F0197-4580(95)00041-C",{"id":28,"text":1479,"url":28,"identifiers":1480},"Wischik, 1995, Quantitative analysis of tau protein in paired helical filament preparations: Implications for the role of tau protein phosphorylation in PHF assembly in Alzheimer’s disease, Neurobiol. Aging, 16, 409, 10.1016\u002F0197-4580(95)97327-D",{"doi":1481},"10.1016\u002F0197-4580(95)97327-D",{"id":28,"text":1483,"url":28,"identifiers":1484},"Jakes, 1991, Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer’s disease, EMBO J., 10, 2725, 10.1002\u002Fj.1460-2075.1991.tb07820.x",{"doi":1485},"10.1002\u002Fj.1460-2075.1991.tb07820.x",{"id":28,"text":1487,"url":28,"identifiers":1488},"Avila, J., Brandt, R., and Kosik, K. (1997). Brain Microtubule Associated Proteins: Modifications in Disease, Harwood Academic Publishers.",{},{"id":28,"text":1490,"url":28,"identifiers":1491},"Gu, 1996, Tau is widely expressed in rat tissues, J. Neurochem., 67, 1235, 10.1046\u002Fj.1471-4159.1996.67031235.x",{"doi":1492},"10.1046\u002Fj.1471-4159.1996.67031235.x",{"id":28,"text":1494,"url":28,"identifiers":1495},"Qiang, 2006, Tau protects microtubules in the axon from severing by katanin, J. Neurosci., 26, 3120, 10.1523\u002FJNEUROSCI.5392-05.2006",{"doi":1496},"10.1523\u002FJNEUROSCI.5392-05.2006",{"id":28,"text":1498,"url":28,"identifiers":1499},"Takei, 2000, Defects in axonal elongation and neuronal migration in mice with disrupted tau and map1b genes, J. Cell Biol., 150, 989, 10.1083\u002Fjcb.150.5.989",{"doi":1500},"10.1083\u002Fjcb.150.5.989",{"id":28,"text":1502,"url":28,"identifiers":1503},"Delacourte, 2000, Tau protein isoforms, phosphorylation and role in neurodegenerative disorders, Brain Res. Rev., 33, 95, 10.1016\u002FS0165-0173(00)00019-9",{"doi":1504},"10.1016\u002FS0165-0173(00)00019-9",{"id":28,"text":1506,"url":28,"identifiers":1507},"Hasegawa, 1995, Hyperphosphorylation of tau in PHF, Neurobiol. Aging, 16, 365, 10.1016\u002F0197-4580(95)00027-C",{"doi":1508},"10.1016\u002F0197-4580(95)00027-C",{"id":28,"text":1510,"url":28,"identifiers":1511},"Bretteville, A., Ando, K., Ghestem, A., Loyens, A., Bégard, S., Beauvillain, J.-C., Sergeant, N., Hamdane, M., and Buée, L. (2009). Two-dimensional electrophoresis of tau mutants reveals specific phosphorylation pattern likely linked to early tau conformational changes. PLoS ONE, 4.",{"doi":1512},"10.1371\u002Fjournal.pone.0004843",{"id":28,"text":1514,"url":28,"identifiers":1515},"Diana, 2003, Phosphorylation pattern of tau associated with distinct changes of the growth cone cytoskeleton, Prog. Mol. Subcell. Biol., 32, 33, 10.1007\u002F978-3-642-55557-2_2",{"doi":1516},"10.1007\u002F978-3-642-55557-2_2",{"id":28,"text":1518,"url":28,"identifiers":1519},"Kingwell, 2015, Neurodegenerative disease: Targeting tau acetylation attenuates neurodegeneration, Nat. Rev. Drug Discov., 14, 748, 10.1038\u002Fnrd4768",{"doi":1520},"10.1038\u002Fnrd4768",{"id":28,"text":1522,"url":28,"identifiers":1523},"Braak, 1991, Neuropathological stageing of Alzheimer-related changes, Acta Neuropathol., 82, 239, 10.1007\u002FBF00308809",{"doi":1524},"10.1007\u002FBF00308809",{"id":28,"text":1526,"url":28,"identifiers":1527},"Braak, 2006, Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry, Acta Neuropathol., 112, 389, 10.1007\u002Fs00401-006-0127-z",{"doi":1528},"10.1007\u002Fs00401-006-0127-z",{"id":28,"text":1530,"url":28,"identifiers":1531},"Ding, 2008, Histone deacetylase 6 interacts with the microtubule-associated protein tau, J. Neurochem., 106, 2119, 10.1111\u002Fj.1471-4159.2008.05564.x",{"doi":1532},"10.1111\u002Fj.1471-4159.2008.05564.x",{"id":28,"text":1534,"url":28,"identifiers":1535},"Huang, 1995, ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation, Neurosci. Lett., 192, 209, 10.1016\u002F0304-3940(95)11649-H",{"doi":1536},"10.1016\u002F0304-3940(95)11649-H",{"id":28,"text":1538,"url":28,"identifiers":1539},"Reynolds, 2008, Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cγ1, Grb2, and Src family kinases, J. Biol. Chem., 283, 18177, 10.1074\u002Fjbc.M709715200",{"doi":1540},"10.1074\u002Fjbc.M709715200",{"id":28,"text":1542,"url":28,"identifiers":1543},"Surridge, 1994, The difference in the binding of phosphatidylinositol distinguishes MAP2 from MAP2C and Tau, Biochemistry, 33, 8051, 10.1021\u002Fbi00192a009",{"doi":1544},"10.1021\u002Fbi00192a009",{"id":28,"text":1546,"url":28,"identifiers":1547},"Flanagan, 1997, The structure of divalent cation-induced aggregates of PIP2 and their alteration by gelsolin and tau, Biophys. J., 73, 1440, 10.1016\u002FS0006-3495(97)78176-1",{"doi":1548},"10.1016\u002FS0006-3495(97)78176-1",{"id":28,"text":1550,"url":28,"identifiers":1551},"Morris, 2011, The many faces of tau, Neuron, 70, 410, 10.1016\u002Fj.neuron.2011.04.009",{"doi":1552},"10.1016\u002Fj.neuron.2011.04.009",{"id":28,"text":1554,"url":28,"identifiers":1555},"Himmelstein, 2012, Tau as a therapeutic target in neurodegenerative disease, Pharmacol. Ther., 136, 8, 10.1016\u002Fj.pharmthera.2012.07.001",{"doi":1556},"10.1016\u002Fj.pharmthera.2012.07.001",{"id":28,"text":1558,"url":28,"identifiers":1559},"Klein, 2002, Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau, J. Neurosci., 22, 698, 10.1523\u002FJNEUROSCI.22-03-00698.2002",{"doi":1560},"10.1523\u002FJNEUROSCI.22-03-00698.2002",{"id":28,"text":1562,"url":28,"identifiers":1563},"Jadhav, 2015, Tau-mediated synaptic damage in Alzheimer’s disease, Transl. Neurosci., 6, 214, 10.1515\u002Ftnsci-2015-0023",{"doi":1564},"10.1515\u002Ftnsci-2015-0023",{"id":28,"text":1566,"url":28,"identifiers":1567},"Dudilot, 2012, Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-d-aspartate receptor-dependent tau phosphorylation, J. Biol. Chem., 287, 32040, 10.1074\u002Fjbc.M112.401240",{"doi":1568},"10.1074\u002Fjbc.M112.401240",{"id":28,"text":1570,"url":28,"identifiers":1571},"Ahmed, 2014, Cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion, Neurobiol. Aging, 35, 2474, 10.1016\u002Fj.neurobiolaging.2014.05.005",{"doi":1572},"10.1016\u002Fj.neurobiolaging.2014.05.005",{"id":28,"text":1574,"url":28,"identifiers":1575},"Regan, 2015, Tau phosphorylation at serine 396 residue is required for hippocampal LTD, J. Neurosci., 35, 4804, 10.1523\u002FJNEUROSCI.2842-14.2015",{"doi":1576},"10.1523\u002FJNEUROSCI.2842-14.2015",{"id":28,"text":1578,"url":28,"identifiers":1579},"Sultan, 2011, Nuclear tau, a key player in neuronal DNA protection, J. Biol. Chem., 286, 4566, 10.1074\u002Fjbc.M110.199976",{"doi":1580},"10.1074\u002Fjbc.M110.199976",{"id":28,"text":1582,"url":28,"identifiers":1583},"Perez, 2009, Tau-an inhibitor of deacetylase HDAC6 function, J. Neurochem., 109, 1756, 10.1111\u002Fj.1471-4159.2009.06102.x",{"doi":1584},"10.1111\u002Fj.1471-4159.2009.06102.x",{"id":28,"text":1586,"url":28,"identifiers":1587},"Leyk, 2015, Inhibition of HDAC6 modifies tau inclusion body formation and impairs autophagic clearance, J. Mol. Neurosci., 55, 1031, 10.1007\u002Fs12031-014-0460-y",{"doi":1588},"10.1007\u002Fs12031-014-0460-y",{"id":28,"text":1590,"url":28,"identifiers":1591},"Davies, P., and Maloney, A.J. (1976). Selective loss of central cholinergic neurons in Alzheimer’s disease. Lancet.",{"doi":1592},"10.1016\u002FS0140-6736(76)91936-X",{"id":28,"text":1594,"url":28,"identifiers":1595},"Whitehouse, 1981, Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis, Ann. Neurol., 10, 122, 10.1002\u002Fana.410100203",{"doi":1596},"10.1002\u002Fana.410100203",{"id":28,"text":1598,"url":28,"identifiers":1599},"Glenner, 1984, Alzheimer’s disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein, Biochem. Biophys. Res. Commun., 120, 885, 10.1016\u002FS0006-291X(84)80190-4",{"doi":1600},"10.1016\u002FS0006-291X(84)80190-4",{"id":28,"text":1602,"url":28,"identifiers":1603},"Wong, 1985, Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related, Proc. Natl. Acad. Sci. USA, 82, 8729, 10.1073\u002Fpnas.82.24.8729",{"doi":1604},"10.1073\u002Fpnas.82.24.8729",{"id":28,"text":1606,"url":28,"identifiers":1607},"Glenner, 1984, Alzheimer’s disease and Down’s syndrome: Sharing of a unique cerebrovascular amyloid fibril protein, Biochem. Biophys. Res. Commun., 122, 1131, 10.1016\u002F0006-291X(84)91209-9",{"doi":1608},"10.1016\u002F0006-291X(84)91209-9",{"id":28,"text":1610,"url":28,"identifiers":1611},"Goate, 1991, Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease, Nature, 349, 704, 10.1038\u002F349704a0",{"doi":1612},"10.1038\u002F349704a0",{"id":28,"text":1614,"url":28,"identifiers":1615},"Hardy, 1991, Amyloid deposition as the central event in the aetiology of Alzheimer’s disease, Trends Pharmacol. Sci., 12, 383, 10.1016\u002F0165-6147(91)90609-V",{"doi":1616},"10.1016\u002F0165-6147(91)90609-V",{"id":28,"text":1618,"url":28,"identifiers":1619},"Hardy, 1992, Alzheimer’s disease: The amyloid cascade hypothesis, Science, 256, 184, 10.1126\u002Fscience.1566067",{"doi":1620},"10.1126\u002Fscience.1566067",{"id":28,"text":1622,"url":28,"identifiers":1623},"Blanquet, 1987, The beta amyloid protein (AD-AP) cDNA hybridizes in normal and Alzheimer individuals near the interface of 21q21 and q22.1, Ann. Génétique, 30, 68",{},{"id":28,"text":1625,"url":28,"identifiers":1626},"Robakis, 1987, Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome, Lancet, 1, 384, 10.1016\u002FS0140-6736(87)91754-5",{"doi":1627},"10.1016\u002FS0140-6736(87)91754-5",{"id":28,"text":1629,"url":28,"identifiers":1630},"Tanzi, 1987, The genetic defect causing familial Alzheimer’s disease maps on chromosome 21, Science, 235, 885, 10.1126\u002Fscience.2880399",{"doi":1631},"10.1126\u002Fscience.2880399",{"id":28,"text":1633,"url":28,"identifiers":1634},"Goldgaber, 1987, Isolation, characterization, and chromosomal localization of human brain cDNA clones coding for the precursor of the amyloid of brain in Alzheimer’s disease, Down’s syndrome and aging, J. Neural Transm., 24, 23",{},{"id":28,"text":1636,"url":28,"identifiers":1637},"Haan, 1990, Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch), Science, 248, 1120, 10.1126\u002Fscience.1971458",{"doi":1638},"10.1126\u002Fscience.1971458",{"id":28,"text":1640,"url":28,"identifiers":1641},"Levy, 1990, Mutation of the Alzheimer’s disease amyloid gene in hereditary cerebral hemorrhage, Dutch type, Science, 248, 1124, 10.1126\u002Fscience.2111584",{"doi":1642},"10.1126\u002Fscience.2111584",{"id":28,"text":1644,"url":28,"identifiers":1645},"Lowenberg, 1934, Familial organic psychosis (Alzheimer’s type), Arch. Neurol., 31, 737, 10.1001\u002Farchneurpsyc.1934.02250040061004",{"doi":1646},"10.1001\u002Farchneurpsyc.1934.02250040061004",{"id":28,"text":1648,"url":28,"identifiers":1649},"Haines, 1992, Genetic evidence for a novel familial Alzheimer’s disease locus on chromosome 14, Nat. Genet., 2, 330, 10.1038\u002Fng1292-330",{"doi":1650},"10.1038\u002Fng1292-330",{"id":28,"text":1652,"url":28,"identifiers":1653},"Sherrington, 1995, Cloning of a gene bearing missense mutations in early-onset familial Alzheimer’s disease, Nature, 375, 754, 10.1038\u002F375754a0",{"doi":1654},"10.1038\u002F375754a0",{"id":28,"text":1656,"url":28,"identifiers":1657},"Schellenberg, 1992, Genetic linkage evidence for a familial Alzheimer’s disease locus on chromosome 14, Science, 258, 668, 10.1126\u002Fscience.1411576",{"doi":1658},"10.1126\u002Fscience.1411576",{"id":28,"text":1660,"url":28,"identifiers":1661},"Wasco, 1995, Candidate gene for the chromosome 1 familial Alzheimer’s disease locus, Science, 269, 973, 10.1126\u002Fscience.7638622",{"doi":1662},"10.1126\u002Fscience.7638622",{"id":28,"text":1664,"url":28,"identifiers":1665},"Czech, 2000, Presenilins and Alzheimer’s disease: Biological functions and pathogenic mechanisms, Prog. Neurobiol., 60, 363, 10.1016\u002FS0301-0082(99)00033-7",{"doi":1666},"10.1016\u002FS0301-0082(99)00033-7",{"id":28,"text":1668,"url":28,"identifiers":1669},"Citron, 1997, Mutant presenilins of Alzheimer’s disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice, Nat. Med., 3, 67, 10.1038\u002Fnm0197-67",{"doi":1670},"10.1038\u002Fnm0197-67",{"id":28,"text":1672,"url":28,"identifiers":1673},"Okochi, 2002, Presenilins mediate a dual intramembranous γ-secretase cleavage of Notch-1, EMBO J., 21, 5408, 10.1093\u002Femboj\u002Fcdf541",{"doi":1674},"10.1093\u002Femboj\u002Fcdf541",{"id":28,"text":1676,"url":28,"identifiers":1677},"De Strooper, B., Iwatsubo, T., and Wolfe, M.S. (2012). Presenilins and γ-secretase: Structure, function, and role in Alzheimer Disease. Cold Spring Harb. Perspect. Med.",{"doi":1678},"10.1101\u002Fcshperspect.a006304",{"id":28,"text":1680,"url":28,"identifiers":1681},"Shen, 1997, Skeletal and CNS defects in Presenilin-1-deficient mice, Cell, 89, 629, 10.1016\u002FS0092-8674(00)80244-5",{"doi":1682},"10.1016\u002FS0092-8674(00)80244-5",{"id":28,"text":1684,"url":28,"identifiers":1685},"Tollefsbol, T. (2010). Epigenetics of Aging, Springer.",{"doi":1686},"10.1007\u002F978-1-4419-0639-7",{"id":28,"text":1688,"url":28,"identifiers":1689},"Strittmatter, 1993, Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease, Proc. Natl. Acad. Sci. USA, 90, 1977, 10.1073\u002Fpnas.90.5.1977",{"doi":1690},"10.1073\u002Fpnas.90.5.1977",{"id":28,"text":1692,"url":28,"identifiers":1693},"Saunders, 1993, Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer’s disease, Neurology, 43, 1467, 10.1212\u002FWNL.43.8.1467",{"doi":1694},"10.1212\u002FWNL.43.8.1467",{"id":28,"text":1696,"url":28,"identifiers":1697},"Strittmatter, 2012, Old drug, new hope for Alzheimer’s disease, Science, 335, 1447, 10.1126\u002Fscience.1220725",{"doi":1698},"10.1126\u002Fscience.1220725",{"id":28,"text":1700,"url":28,"identifiers":1701},"Mawuenyega, K.G., Sigurdson, W., Ovod, V., Munsell, L., Kasten, T., Morris, J.C., Yarasheski, K.E., and Bateman, R.J. (2010). Decreased clearance of CNS beta-amyloid in Alzheimer’s disease. Science.",{"doi":1702},"10.1126\u002Fscience.1197623",{"id":28,"text":1704,"url":28,"identifiers":1705},"Castellano, J.M., Kim, J., Stewart, F.R., Jiang, H., DeMattos, R.B., Patterson, B.W., Fagan, A.M., Morris, J.C., Mawuenyega, K.G., and Cruchaga, C. (2011). Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Sci. Transl. Med.",{"doi":1706},"10.1126\u002Fscitranslmed.3002156",{"id":28,"text":1708,"url":28,"identifiers":1709},"Qu, 2014, Beta-amyloid auto-antibodies are reduced in Alzheimer’s disease, J. Neuroimmunol., 274, 168, 10.1016\u002Fj.jneuroim.2014.06.017",{"doi":1710},"10.1016\u002Fj.jneuroim.2014.06.017",{"id":28,"text":1712,"url":28,"identifiers":1713},"Cacabelos, 2007, Pharmacogenetic basis for therapeutic optimization in Alzheimer’s disease, Mol. Diagn. Ther., 11, 385, 10.1007\u002FBF03256262",{"doi":1714},"10.1007\u002FBF03256262",{"id":28,"text":1716,"url":28,"identifiers":1717},"Hollingworth, 2011, Common variants at ABCA7, MS4A6A\u002FMS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease, Nat. Genet., 43, 429, 10.1038\u002Fng.803",{"doi":1718},"10.1038\u002Fng.803",{"id":28,"text":1720,"url":28,"identifiers":1721},"Naj, 2011, Common variants at MS4A4\u002FMS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer’s disease, Nat. Genet., 43, 436, 10.1038\u002Fng.801",{"doi":1722},"10.1038\u002Fng.801",{"id":28,"text":1724,"url":28,"identifiers":1725},"Lardenoije, 2015, The epigenetics of aging and neurodegeneration, Prog. Neurobiol., 131, 21, 10.1016\u002Fj.pneurobio.2015.05.002",{"doi":1726},"10.1016\u002Fj.pneurobio.2015.05.002",{"id":28,"text":1728,"url":28,"identifiers":1729},"Jonsson, 2013, Variant of TREM2 associated with the risk of Alzheimer’s disease, N. Engl. J. Med., 368, 107, 10.1056\u002FNEJMoa1211103",{"doi":1730},"10.1056\u002FNEJMoa1211103",{"id":28,"text":1732,"url":28,"identifiers":1733},"Cruchaga, 2014, Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease, Nature, 505, 550, 10.1038\u002Fnature12825",{"doi":1734},"10.1038\u002Fnature12825",{"id":28,"text":1736,"url":28,"identifiers":1737},"Guerreiro, 2013, TREM2 variants in Alzheimer’s disease, N. Engl. J. Med., 368, 117, 10.1056\u002FNEJMoa1211851",{"doi":1738},"10.1056\u002FNEJMoa1211851",{"id":28,"text":1740,"url":28,"identifiers":1741},"Arriagada, 1992, Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease, Neurology, 42, 631, 10.1212\u002FWNL.42.3.631",{"doi":1742},"10.1212\u002FWNL.42.3.631",{"id":28,"text":1744,"url":28,"identifiers":1745},"Bierer, 1995, Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer’s disease, Arch. Neurol., 52, 81, 10.1001\u002Farchneur.1995.00540250089017",{"doi":1746},"10.1001\u002Farchneur.1995.00540250089017",{"id":28,"text":1748,"url":28,"identifiers":1749},"Bancher, 1989, Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer’s disease, Brain Res., 477, 90, 10.1016\u002F0006-8993(89)91396-6",{"doi":1750},"10.1016\u002F0006-8993(89)91396-6",{"id":28,"text":1752,"url":28,"identifiers":1753},"Braak, 1994, Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat, Neurosci. Lett., 171, 1, 10.1016\u002F0304-3940(94)90589-4",{"doi":1754},"10.1016\u002F0304-3940(94)90589-4",{"id":28,"text":1756,"url":28,"identifiers":1757},"Joshi, 2014, Neuroinflammation and Alzheimer’s disease: Lessons learned from 5-lypoxigenase, Transl. Neurosci., 5, 197, 10.2478\u002Fs13380-014-0225-7",{"doi":1758},"10.2478\u002Fs13380-014-0225-7",{"id":28,"text":1760,"url":28,"identifiers":1761},"Wang, 2011, BDNF-trkB signaling in late life cognitive decline and Alzheimer’s disease, Transl. Neurosci., 2, 91, 10.2478\u002Fs13380-011-0015-4",{"doi":1762},"10.2478\u002Fs13380-011-0015-4",{"id":28,"text":1764,"url":28,"identifiers":1765},"Pollock, N., Mirra, S., Binder, L., Hansen, L., and Wood, J. (1986). Filamentous aggregates in Pick’s disease, progressive supranuclear palsy, and Alzheimer’s disease share antigenic determinants with microtubule-associated protein, tau. Lancet, 204–205.",{"doi":1766},"10.1097\u002F00002093-198701030-00026",{"id":28,"text":1768,"url":28,"identifiers":1769},"Sergeant, 2005, Tau protein as a differential biomarker of tauopathies, Biochim. Biophys. Acta, 1739, 179, 10.1016\u002Fj.bbadis.2004.06.020",{"doi":1770},"10.1016\u002Fj.bbadis.2004.06.020",{"id":28,"text":1772,"url":28,"identifiers":1773},"Flament, 1991, Abnormal Tau proteins in progressive supranuclear palsy. Similarities and differences with the neurofibrillary degeneration of the Alzheimer type, Acta Neuropathol., 81, 591, 10.1007\u002FBF00296367",{"doi":1774},"10.1007\u002FBF00296367",{"id":28,"text":1776,"url":28,"identifiers":1777},"Morgan, 1994, Ultrastructure and biochemical composition of paired helical filaments in corticobasal degeneration, Am. J. Pathol., 145, 1496",{},{"id":28,"text":1779,"url":28,"identifiers":1780},"Šimić, G. (2002). Pathological tau proteins in argyrophilic grain disease. Lancet Neurol.",{"doi":1781},"10.1016\u002FS1474-4422(02)00130-8",{"id":28,"text":1783,"url":28,"identifiers":1784},"Delacourte, 1996, Specific pathological tau protein variants characterize Pick’s disease, J. Neuropathol. Exp. Neurol., 55, 159, 10.1097\u002F00005072-199602000-00004",{"doi":1785},"10.1097\u002F00005072-199602000-00004",{"id":28,"text":1787,"url":28,"identifiers":1788},"Spillantini, 1998, Tau protein pathology in neurodegenerative diseases, Trends Neurosci., 21, 428, 10.1016\u002FS0166-2236(98)01337-X",{"doi":1789},"10.1016\u002FS0166-2236(98)01337-X",{"id":28,"text":1791,"url":28,"identifiers":1792},"Wilhelmsen, 1994, Localization of disinhibition-dementia-parkinsonism-amyotrophy complex to 17q21–22, Am. J. Hum. Genet., 55, 1159",{},{"id":28,"text":1794,"url":28,"identifiers":1795},"Spillantini, 1997, Familial multiple system tauopathy with presenile dementia: A disease with abundant neuronal and glial tau filaments, Proc. Natl. Acad. Sci. USA, 94, 4113, 10.1073\u002Fpnas.94.8.4113",{"doi":1796},"10.1073\u002Fpnas.94.8.4113",{"id":28,"text":1798,"url":28,"identifiers":1799},"Murrell, 1997, Familial multiple-system tauopathy with presenile dementia is localized to chromosome 17, Am. J. Hum. Genet., 61, 1131, 10.1086\u002F301594",{"doi":1800},"10.1086\u002F301594",{"id":28,"text":1802,"url":28,"identifiers":1803},"Foster, 1997, Frontotemporal dementia and parkinsonism linked to chromosome 17: A consensus conference. Conference Participants, Ann. Neurol., 41, 706, 10.1002\u002Fana.410410606",{"doi":1804},"10.1002\u002Fana.410410606",{"id":28,"text":1806,"url":28,"identifiers":1807},"Spillantini, 1998, Mutation in the tau gene in familial multiple system tauopathy with presenile dementia, Proc. Natl. Acad. Sci. USA, 95, 7737, 10.1073\u002Fpnas.95.13.7737",{"doi":1808},"10.1073\u002Fpnas.95.13.7737",{"id":28,"text":1810,"url":28,"identifiers":1811},"Poorkaj, 1998, Tau is a candidate gene for chromosome 17 frontotemporal dementia, Ann. Neurol., 43, 815, 10.1002\u002Fana.410430617",{"doi":1812},"10.1002\u002Fana.410430617",{"id":28,"text":1814,"url":28,"identifiers":1815},"Hutton, 1998, Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17, Nature, 393, 702, 10.1038\u002F31508",{"doi":1816},"10.1038\u002F31508",{"id":28,"text":1818,"url":28,"identifiers":1819},"Hasegawa, 1998, Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly, FEBS Lett., 437, 207, 10.1016\u002FS0014-5793(98)01217-4",{"doi":1820},"10.1016\u002FS0014-5793(98)01217-4",{"id":28,"text":1822,"url":28,"identifiers":1823},"Hong, 1998, Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17, Science, 282, 1914, 10.1126\u002Fscience.282.5395.1914",{"doi":1824},"10.1126\u002Fscience.282.5395.1914",{"id":28,"text":1826,"url":28,"identifiers":1827},"1998, Cytoskeletal changes as an alternative view on pathogenesis of Alzheimer’s disease, Period. Biol., 100, 165",{},{"id":28,"text":1829,"url":28,"identifiers":1830},"Bhatia, 2013, Untangling the role of tau in Alzheimer’s disease: A unifying hypothesis, Transl. Neurosci., 4, 115, 10.2478\u002Fs13380-013-0114-5",{"doi":1831},"10.2478\u002Fs13380-013-0114-5",{"id":28,"text":1833,"url":28,"identifiers":1834},"Dermaut, 2004, A novel presenilin 1 mutation associated with Pick’s disease but not beta-amyloid plaques, Ann. Neurol., 55, 617, 10.1002\u002Fana.20083",{"doi":1835},"10.1002\u002Fana.20083",{"id":28,"text":1837,"url":28,"identifiers":1838},"Vandrovcova, 2009, Association of MAPT haplotype-tagging SNPs with sporadic Parkinson’s disease, Neurobiol. Aging, 30, 1477, 10.1016\u002Fj.neurobiolaging.2007.11.019",{"doi":1839},"10.1016\u002Fj.neurobiolaging.2007.11.019",{"id":28,"text":1841,"url":28,"identifiers":1842},"Dawson, 2001, Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice, J. Cell Sci., 114, 1179, 10.1242\u002Fjcs.114.6.1179",{"doi":1843},"10.1242\u002Fjcs.114.6.1179",{"id":28,"text":1845,"url":28,"identifiers":1846},"Terry, 1996, The pathogenesis of Alzheimer’s disease: An alternative to the amyloid hypothesis, J. Neuropathol. Exp. Neurol., 55, 1023, 10.1097\u002F00005072-199655100-00001",{"doi":1847},"10.1097\u002F00005072-199655100-00001",{"id":28,"text":1849,"url":28,"identifiers":1850},"Kopeikina, 2012, Soluble forms of tau are toxic in Alzheimer’s disease, Transl. Neurosci., 3, 223, 10.2478\u002Fs13380-012-0032-y",{"doi":1851},"10.2478\u002Fs13380-012-0032-y",{"id":28,"text":1853,"url":28,"identifiers":1854},"Harrington, 1991, Measurement of distinct immunochemical presentations of tau protein in Alzheimer disease, Proc. Natl. Acad. Sci. USA, 88, 5842, 10.1073\u002Fpnas.88.13.5842",{"doi":1855},"10.1073\u002Fpnas.88.13.5842",{"id":28,"text":1857,"url":28,"identifiers":1858},"Novak, 1993, Molecular characterization of the minimal protease resistant tau unit of the Alzheimer’s disease paired helical filament, EMBO J., 12, 365, 10.1002\u002Fj.1460-2075.1993.tb05665.x",{"doi":1859},"10.1002\u002Fj.1460-2075.1993.tb05665.x",{"id":28,"text":1861,"url":28,"identifiers":1862},"Wischik, 1996, Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines, Proc. Natl. Acad. Sci. USA, 93, 11213, 10.1073\u002Fpnas.93.20.11213",{"doi":1863},"10.1073\u002Fpnas.93.20.11213",{"id":28,"text":1865,"url":28,"identifiers":1866},"Harrington, 2015, Cellular models of aggregation-dependent template-directed proteolysis to characterize tau aggregation inhibitors for treatment of Alzheimer’s Disease, J. Biol. Chem., 290, 10862, 10.1074\u002Fjbc.M114.616029",{"doi":1867},"10.1074\u002Fjbc.M114.616029",{"id":28,"text":1869,"url":28,"identifiers":1870},"Hrnkova, 2007, Neurodegeneration caused by expression of human truncated tau leads to progressive neurobehavioural impairment in transgenic rats, Brain Res., 1130, 206, 10.1016\u002Fj.brainres.2006.10.085",{"doi":1871},"10.1016\u002Fj.brainres.2006.10.085",{"id":28,"text":1873,"url":28,"identifiers":1874},"Zilka, 2006, Truncated tau from sporadic Alzheimer’s disease suffices to drive neurofibrillary degeneration in vivo, FEBS Lett., 580, 3582, 10.1016\u002Fj.febslet.2006.05.029",{"doi":1875},"10.1016\u002Fj.febslet.2006.05.029",{"id":28,"text":1877,"url":28,"identifiers":1878},"Wang, 2009, Tau fragmentation, aggregation and clearance: The dual role of lysosomal processing, Hum. Mol. Genet., 18, 4153, 10.1093\u002Fhmg\u002Fddp367",{"doi":1879},"10.1093\u002Fhmg\u002Fddp367",{"id":28,"text":1881,"url":28,"identifiers":1882},"Wischik, 2014, Tau-aggregation inhibitor therapy for Alzheimer’s disease, Biochem. Pharmacol., 88, 529, 10.1016\u002Fj.bcp.2013.12.008",{"doi":1883},"10.1016\u002Fj.bcp.2013.12.008",{"id":28,"text":1885,"url":28,"identifiers":1886},"Hurt, 2000, Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer’s disease, Am. J. Pathol., 157, 623, 10.1016\u002FS0002-9440(10)64573-7",{"doi":1887},"10.1016\u002FS0002-9440(10)64573-7",{"id":28,"text":1889,"url":28,"identifiers":1890},"Callahan, 2002, Progressive reduction of synaptophysin message in single neurons in Alzheimer disease, J. Neuropathol. Exp. Neurol., 61, 384, 10.1093\u002Fjnen\u002F61.5.384",{"doi":1891},"10.1093\u002Fjnen\u002F61.5.384",{"id":28,"text":1893,"url":28,"identifiers":1894},"Liu, 1996, Regional and laminar synaptic pathology in frontal lobe degeneration of non-Alzheimer type, Int. J. Geriatr. Psychiatry, 11, 47, 10.1002\u002F(SICI)1099-1166(199601)11:1\u003C47::AID-GPS285>3.0.CO;2-M",{"doi":1895},"10.1002\u002F(SICI)1099-1166(199601)11:1\u003C47::AID-GPS285>3.0.CO;2-M",{"id":28,"text":1897,"url":28,"identifiers":1898},"Suzuki, 1995, Neurofibrillary tangles in Niemann-Pick disease type C, Acta Neuropathol., 89, 227, 10.1007\u002FBF00309338",{"doi":1899},"10.1007\u002FBF00309338",{"id":28,"text":1901,"url":28,"identifiers":1902},"Dujardin, S., Lécolle, K., Caillierez, R., Bégard, S., Zommer, N., Lachaud, C., Carrier, S., Dufour, N., Aurégan, G., and Winderickx, J. (2014). Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: Relevance to sporadic tauopathies. Acta Neuropathol. Commun.",{"doi":1903},"10.1186\u002F2051-5960-2-14",{"id":28,"text":1905,"url":28,"identifiers":1906},"Hall, 2012, Is tau ready for admission to the prion club?, Prion, 6, 223, 10.4161\u002Fpri.19912",{"doi":1907},"10.4161\u002Fpri.19912",{"id":28,"text":1909,"url":28,"identifiers":1910},"Iba, 2013, Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer’s-like tauopathy, J. Neurosci., 33, 1024, 10.1523\u002FJNEUROSCI.2642-12.2013",{"doi":1911},"10.1523\u002FJNEUROSCI.2642-12.2013",{"id":28,"text":1913,"url":28,"identifiers":1914},"Frost, 2009, Propagation of tau misfolding from the outside to the inside of a cell, J. Biol. Chem., 284, 12845, 10.1074\u002Fjbc.M808759200",{"doi":1915},"10.1074\u002Fjbc.M808759200",{"id":28,"text":1917,"url":28,"identifiers":1918},"Polydoro, 2012, Propagation of tau pathology in a model of early Alzheimer’s disease, Neuron, 73, 685, 10.1016\u002Fj.neuron.2011.11.033",{"doi":1919},"10.1016\u002Fj.neuron.2011.11.033",{"id":28,"text":1921,"url":28,"identifiers":1922},"Liu, L., Drouet, V., Wu, J.W., Witter, M.P., Small, S.A., Clelland, C., and Duff, K. (2012). Trans-synaptic spread of tau pathology in vivo. PLoS ONE, 7.",{"doi":1923},"10.1371\u002Fjournal.pone.0031302",{"id":28,"text":1925,"url":28,"identifiers":1926},"Yanamandra, 2013, Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo, Neuron, 80, 402, 10.1016\u002Fj.neuron.2013.07.046",{"doi":1927},"10.1016\u002Fj.neuron.2013.07.046",{"id":28,"text":1929,"url":28,"identifiers":1930},"Rubinsztein, 2006, The roles of intracellular protein-degradation pathways in neurodegeneration, Nature, 443, 780, 10.1038\u002Fnature05291",{"doi":1931},"10.1038\u002Fnature05291",{"id":28,"text":1933,"url":28,"identifiers":1934},"Holmes, 2014, Proteopathic tau seeding predicts tauopathy in vivo, Proc. Natl. Acad. Sci. USA, 111, E4376, 10.1073\u002Fpnas.1411649111",{"doi":1935},"10.1073\u002Fpnas.1411649111",{"id":28,"text":1937,"url":28,"identifiers":1938},"Asai, 2015, Depletion of microglia and inhibition of exosome synthesis halt tau propagation, Nat. Neurosci., 18, 1584, 10.1038\u002Fnn.4132",{"doi":1939},"10.1038\u002Fnn.4132",{"id":28,"text":1941,"url":28,"identifiers":1942},"Avila, 2015, AD genetic risk factors and tau spreading, Front. Aging Neurosci., 7, 1088, 10.3389\u002Ffnagi.2015.00099",{"doi":1943},"10.3389\u002Ffnagi.2015.00099",{"id":28,"text":1945,"url":28,"identifiers":1946},"Klafki, 2006, An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice, Proc. Natl. Acad. Sci. USA, 103, 9673, 10.1073\u002Fpnas.0602913103",{"doi":1947},"10.1073\u002Fpnas.0602913103",{"id":28,"text":1949,"url":28,"identifiers":1950},"Varghese, 2014, Green coffee as a novel agent for Alzheimer’s disease prevention by attenuating diabetes, Transl. Neurosci., 5, 111, 10.2478\u002Fs13380-014-0213-y",{"doi":1951},"10.2478\u002Fs13380-014-0213-y",{"id":28,"text":1953,"url":28,"identifiers":1954},"Berger, 2006, Rapamycin alleviates toxicity of different aggregate-prone proteins, Hum. Mol. Genet., 15, 433, 10.1093\u002Fhmg\u002Fddi458",{"doi":1955},"10.1093\u002Fhmg\u002Fddi458",{"id":28,"text":1957,"url":28,"identifiers":1958},"Troquier, 2012, Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: A suitable therapeutic approach, Curr. Alzheimer Res., 9, 397, 10.2174\u002F156720512800492503",{"doi":1959},"10.2174\u002F156720512800492503",{"id":28,"text":1961,"url":28,"identifiers":1962},"Dawidowitz, 2012, Targeting tau for Alzheimer’s disease and related neurodegenerative disorders, Drug Discov., 3, 16",{},{"id":28,"text":1964,"url":28,"identifiers":1965},"Steinwachs, 2013, Treatment of Alzheimer’s Disease with the GSK-3 Inhibitor Tideglusib: A Pilot Study, J. Alzheimers. Dis., 33, 205",{},{"id":28,"text":1967,"url":28,"identifiers":1968},"Baddeley, 2015, Complex disposition of methylthioninium redox forms determines efficacy in tau aggregation inhibitor therapy for Alzheimer’s disease, J. Pharmacol. Exp. Ther., 352, 110, 10.1124\u002Fjpet.114.219352",{"doi":1969},"10.1124\u002Fjpet.114.219352",{"id":28,"text":1971,"url":28,"identifiers":1972},"Wischik, 2015, Tau aggregation inhibitor therapy: An exploratory phase 2 study in mild or moderate Alzheimer’s disease, J. Alzheimers. Dis., 44, 705, 10.3233\u002FJAD-142874",{"doi":1973},"10.3233\u002FJAD-142874",{"id":28,"text":1975,"url":28,"identifiers":1976},"Grinberg, 2013, Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation, Acta Neuropathol., 125, 581, 10.1007\u002Fs00401-013-1080-2",{"doi":1977},"10.1007\u002Fs00401-013-1080-2",{"id":28,"text":1979,"url":28,"identifiers":1980},"Mohideen, S., Yamasaki, Y., Omata, Y., Tsuda, L., and Yoshiike, Y. (2015). Nontoxic singlet oxygen generator as a therapeutic candidate for treating tauopathies. Sci. Rep.",{},{"id":28,"text":1982,"url":28,"identifiers":1983},"Melis, 2015, Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models, Behav. Pharmacol., 26, 353, 10.1097\u002FFBP.0000000000000133",{"doi":1984},"10.1097\u002FFBP.0000000000000133",{"id":28,"text":1986,"url":28,"identifiers":1987},"Stack, 2014, Methylene blue upregulates Nrf2\u002FARE genes and prevents tau-relatd neurotoxicity, Hum. Mol. Genet., 23, 3716, 10.1093\u002Fhmg\u002Fddu080",{"doi":1988},"10.1093\u002Fhmg\u002Fddu080",{"id":28,"text":1990,"url":28,"identifiers":1991},"Pakavathkumar, P., Sharma, G., Kaushal, V., Foveau, B., and LeBlanc, A. (2015). Methylene blue inhibits caspases by oxidation of the catalytic cysteine. Sci. Rep.",{"doi":1992},"10.1038\u002Fsrep13730",{"id":28,"text":1994,"url":28,"identifiers":1995},"Hochgräfe, K., Sydow, A., Matenia, D., Cadinu, D., Könen, S., Petrova, O., Pickhardt, M., Goll, P., Morellini, F., and Mandelkow, E. (2015). Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau. Acta Neuropathol. Commun.",{"doi":1996},"10.1186\u002Fs40478-015-0204-4",{"id":28,"text":1998,"url":28,"identifiers":1999},"Bulic, 2010, Tau protein and tau aggregation inhibitors, Neuropharmacology, 59, 276, 10.1016\u002Fj.neuropharm.2010.01.016",{"doi":2000},"10.1016\u002Fj.neuropharm.2010.01.016",{"id":28,"text":2002,"url":28,"identifiers":2003},"Jun, G., Ibrahim-Verbaas, C.A., Vronskaya, M., Lambert, J.-C., Chung, J., Naj, A.C., Kunkle, B.W., Wang, L.-S., Bis, J.C., and Bellenguez, C. (2015). A novel Alzheimer disease locus located near the gene encoding tau protein. Mol. Psychiatry.",{},{"id":28,"text":2005,"url":28,"identifiers":2006},"Mladinov, 2009, Does Alzheimer’s disease begin in the brainstem?, Neuropathol. Appl. 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Global Surveillance, Prevention and Control of Chronic Respiratory Diseases: A Comprehensive Approach, WHO.",{},{"id":28,"text":2115,"url":28,"identifiers":2116},"Decramer, 2012, Chronic obstructive pulmonary disease, Lancet, 379, 1341, 10.1016\u002FS0140-6736(11)60968-9",{"doi":2117},"10.1016\u002FS0140-6736(11)60968-9",{"id":28,"text":2119,"url":28,"identifiers":2120},"Ambrosino, 2012, The management of asthma and chronic obstructive pulmonary disease: Current status and future perspectives, Expert Rev. Respir. Med., 6, 117, 10.1586\u002Fers.12.2",{"doi":2121},"10.1586\u002Fers.12.2",{"id":28,"text":2123,"url":28,"identifiers":2124},"Tetley, 2005, Inflammatory cells and chronic obstructive pulmonary disease, Curr. Drug Targets Inflamm. Allergy, 4, 607, 10.2174\u002F156801005774912824",{"doi":2125},"10.2174\u002F156801005774912824",{"id":28,"text":2127,"url":28,"identifiers":2128},"Tubby, 2011, Immunological basis of reversible and fixed airways disease, Clin. Sci., 121, 285, 10.1042\u002FCS20110062",{"doi":2129},"10.1042\u002FCS20110062",{"id":28,"text":2131,"url":28,"identifiers":2132},"Papiris, S.A., Kollintza, A., Karatza, M., Manali, E.D., Sotiropoulou, C., Milic-Emili, J., Roussos, C., and Daniil, Z. (2007). CD8+ T lymphocytes in bronchoalveolar lavage in idiopathic pulmonary fibrosis. J. Inflamm.",{"doi":2133},"10.1186\u002F1476-9255-4-14",{"id":28,"text":2135,"url":28,"identifiers":2136},"Durham, 2011, Steroid resistance in severe asthma: Current mechanisms and future treatment, Curr. Pharm. Des., 17, 674, 10.2174\u002F138161211795428984",{"doi":2137},"10.2174\u002F138161211795428984",{"id":28,"text":2139,"url":28,"identifiers":2140},"Salter, 2007, Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease, Am. J. Physiol. Lung Cell. Mol. Physiol., 293, L660, 10.1152\u002Fajplung.00108.2007",{"doi":2141},"10.1152\u002Fajplung.00108.2007",{"id":28,"text":2143,"url":28,"identifiers":2144},"Ghosh, 1998, NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses, Annu. Rev. Immunol., 16, 225, 10.1146\u002Fannurev.immunol.16.1.225",{"doi":2145},"10.1146\u002Fannurev.immunol.16.1.225",{"id":28,"text":2147,"url":28,"identifiers":2148},"Hinz, 2014, The IκB kinase complex in NF-κB regulation and beyond, EMBO Rep., 15, 46, 10.1002\u002Fembr.201337983",{"doi":2149},"10.1002\u002Fembr.201337983",{"id":28,"text":2151,"url":28,"identifiers":2152},"Panettieri, 2011, Airway smooth muscle and immunomodulation in acute exacerbations of airway disease, Immunol. Rev., 242, 178, 10.1111\u002Fj.1600-065X.2011.01022.x",{"doi":2153},"10.1111\u002Fj.1600-065X.2011.01022.x",{"id":28,"text":2155,"url":28,"identifiers":2156},"Ward, 2008, Proliferation is not increased in airway myofibroblasts isolated from asthmatics, Eur. Respir. J., 32, 362, 10.1183\u002F09031936.00119307",{"doi":2157},"10.1183\u002F09031936.00119307",{"id":28,"text":2159,"url":28,"identifiers":2160},"Flavell, 2008, Fibroblasts as novel therapeutic targets in chronic inflammation, Br. J. Pharmacol., 153, S241, 10.1038\u002Fsj.bjp.0707487",{"doi":2161},"10.1038\u002Fsj.bjp.0707487",{"id":28,"text":2163,"url":28,"identifiers":2164},"Li, 2011, Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension, J. Immunol., 187, 2711, 10.4049\u002Fjimmunol.1100479",{"doi":2165},"10.4049\u002Fjimmunol.1100479",{"id":28,"text":2167,"url":28,"identifiers":2168},"Edwards, 2009, Targeting the NF-κB pathway in asthma and chronic obstructive pulmonary disease, Pharmacol. Ther., 121, 1, 10.1016\u002Fj.pharmthera.2008.09.003",{"doi":2169},"10.1016\u002Fj.pharmthera.2008.09.003",{"id":28,"text":2171,"url":28,"identifiers":2172},"Rajendrasozhan, 2008, Deacetylases and NF-κB in redox regulation of cigarette smoke-induced lung inflammation: Epigenetics in pathogenesis of COPD, Antioxid. Redox Signal., 10, 799, 10.1089\u002Fars.2007.1938",{"doi":2173},"10.1089\u002Fars.2007.1938",{"id":28,"text":2175,"url":28,"identifiers":2176},"Barnes, 1998, Anti-inflammatory actions of glucocorticoids: Molecular mechanisms, Clin. Sci., 94, 557, 10.1042\u002Fcs0940557",{"doi":2177},"10.1042\u002Fcs0940557",{"id":28,"text":2179,"url":28,"identifiers":2180},"Kagoshima, 2003, Glucocorticoid suppression of nuclear factor-κB: A role for histone modifications, Biochem. Soc. Trans., 31, 60, 10.1042\u002Fbst0310060",{"doi":2181},"10.1042\u002Fbst0310060",{"id":28,"text":2183,"url":28,"identifiers":2184},"Adcock, 2005, Histone deacetylation: An important mechanism in inflammatory lung diseases, COPD, 2, 445, 10.1080\u002F15412550500346683",{"doi":2185},"10.1080\u002F15412550500346683",{"id":28,"text":2187,"url":28,"identifiers":2188},"To, T., Stanojevic, S., Moores, G., Gershon, A.S., Bateman, E.D., Cruz, A.A., and Boulet, L.P. (2012). Global asthma prevalence in adults: Findings from the cross-sectional world health survey. BMC Public Health.",{"doi":2189},"10.1186\u002F1471-2458-12-204",{"id":28,"text":2191,"url":28,"identifiers":2192},"Buist, 2007, International variation in the prevalence of COPD (the BOLD Study): A population-based prevalence study, Lancet, 370, 741, 10.1016\u002FS0140-6736(07)61377-4",{"doi":2193},"10.1016\u002FS0140-6736(07)61377-4",{"id":28,"text":2195,"url":28,"identifiers":2196},"Brusselle, 2014, Targeting immune pathways for therapy in asthma and chronic obstructive pulmonary disease, Ann. Am. Thorac. Soc., 11, S322, 10.1513\u002FAnnalsATS.201403-118AW",{"doi":2197},"10.1513\u002FAnnalsATS.201403-118AW",{"id":28,"text":2199,"url":28,"identifiers":2200},"Hart, 1998, Activation and localization of transcription factor, nuclear factor-κB, in asthma, Am. J. Respir. Crit. Care Med., 158, 1585, 10.1164\u002Fajrccm.158.5.9706116",{"doi":2201},"10.1164\u002Fajrccm.158.5.9706116",{"id":28,"text":2203,"url":28,"identifiers":2204},"Gagliardo, 2003, Persistent activation of nuclear factor-κB signaling pathway in severe uncontrolled asthma, Am. J. Respir. Crit. Care Med., 168, 1190, 10.1164\u002Frccm.200205-479OC",{"doi":2205},"10.1164\u002Frccm.200205-479OC",{"id":28,"text":2207,"url":28,"identifiers":2208},"Tully, 2013, Epithelial NF-κB orchestrates house dust mite-induced airway inflammation, hyperresponsiveness, and fibrotic remodeling, J. Immunol., 191, 5811, 10.4049\u002Fjimmunol.1301329",{"doi":2209},"10.4049\u002Fjimmunol.1301329",{"id":28,"text":2211,"url":28,"identifiers":2212},"Poynter, 2004, NF-κB activation in airways modulates allergic inflammation but not hyperresponsiveness, J. Immunol., 173, 7003, 10.4049\u002Fjimmunol.173.11.7003",{"doi":2213},"10.4049\u002Fjimmunol.173.11.7003",{"id":28,"text":2215,"url":28,"identifiers":2216},"Poynter, 2002, Rapid activation of nuclear factor-κB in airway epithelium in a murine model of allergic airway inflammation, Am. J. Pathol., 160, 1325, 10.1016\u002FS0002-9440(10)62559-X",{"doi":2217},"10.1016\u002FS0002-9440(10)62559-X",{"id":28,"text":2219,"url":28,"identifiers":2220},"Poynter, 2003, A prominent role for airway epithelial NF-κB activation in lipopolysaccharide-induced airway inflammation, J. Immunol., 170, 6257, 10.4049\u002Fjimmunol.170.12.6257",{"doi":2221},"10.4049\u002Fjimmunol.170.12.6257",{"id":28,"text":2223,"url":28,"identifiers":2224},"Quinton, 2007, Functions and regulation of NF-κB RelA during pneumococcal pneumonia, J. Immunol., 178, 1896, 10.4049\u002Fjimmunol.178.3.1896",{"doi":2225},"10.4049\u002Fjimmunol.178.3.1896",{"id":28,"text":2227,"url":28,"identifiers":2228},"Donovan, 1999, NF-κB\u002FRel transcription factors: c-Rel Promotes airway hyperresponsiveness and allergic pulmonary inflammation, J. Immunol., 163, 6827, 10.4049\u002Fjimmunol.163.12.6827",{"doi":2229},"10.4049\u002Fjimmunol.163.12.6827",{"id":28,"text":2231,"url":28,"identifiers":2232},"Li, 2014, Ovalbumin-induced experimental allergic asthma is Toll-like receptor 2 dependent, Allergy Asthma Proc., 35, e15, 10.2500\u002Faap.2014.35.3735",{"doi":2233},"10.2500\u002Faap.2014.35.3735",{"id":28,"text":2235,"url":28,"identifiers":2236},"Lam, 2008, Airway house dust extract exposures modify allergen-induced airway hypersensitivity responses by TLR4-dependent and independent pathways, J. Immunol., 181, 2925, 10.4049\u002Fjimmunol.181.4.2925",{"doi":2237},"10.4049\u002Fjimmunol.181.4.2925",{"id":28,"text":2239,"url":28,"identifiers":2240},"Wilson, 2001, Effects of budesonide and formoterol on NF-κB, adhesion molecules, and cytokines in asthma, Am. J. Respir. Crit. Care Med., 164, 1047, 10.1164\u002Fajrccm.164.6.2010045",{"doi":2241},"10.1164\u002Fajrccm.164.6.2010045",{"id":28,"text":2243,"url":28,"identifiers":2244},"Hancox, 1999, Effects of inhaled beta agonist and corticosteroid treatment on nuclear transcription factors in bronchial mucosa in asthma, Thorax, 54, 488, 10.1136\u002Fthx.54.6.488",{"doi":2245},"10.1136\u002Fthx.54.6.488",{"id":28,"text":2247,"url":28,"identifiers":2248},"Hart, 2000, Effects of inhaled corticosteroid therapy on expression and DNA-binding activity of nuclear factor kappaB in asthma, Am. J. Respir. Crit. Care Med., 161, 224, 10.1164\u002Fajrccm.161.1.9809019",{"doi":2249},"10.1164\u002Fajrccm.161.1.9809019",{"id":28,"text":2251,"url":28,"identifiers":2252},"Caramori, 2002, Increased expression of nuclear factor-κB in bronchial biopsies from smokers and patients with COPD, Eur. Respir. J., 20, 556, 10.1183\u002F09031936.02.00272002",{"doi":2253},"10.1183\u002F09031936.02.00272002",{"id":28,"text":2255,"url":28,"identifiers":2256},"Caramori, 2003, Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations, Thorax, 58, 348, 10.1136\u002Fthorax.58.4.348",{"doi":2257},"10.1136\u002Fthorax.58.4.348",{"id":28,"text":2259,"url":28,"identifiers":2260},"Szulakowski, 2006, The effect of smoking on the transcriptional regulation of lung inflammation in patients with chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med., 174, 41, 10.1164\u002Frccm.200505-725OC",{"doi":2261},"10.1164\u002Frccm.200505-725OC",{"id":28,"text":2263,"url":28,"identifiers":2264},"Gagliardo, 2011, IκB kinase-driven nuclear factor-κB activation in patients with asthma and chronic obstructive pulmonary disease, J. Allergy Clin. Immunol., 128, 635.e2, 10.1016\u002Fj.jaci.2011.03.045",{"doi":2265},"10.1016\u002Fj.jaci.2011.03.045",{"id":28,"text":2267,"url":28,"identifiers":2268},"Brown, V., Elborn, J.S., Bradley, J., and Ennis, M. (2009). Dysregulated apoptosis and NFκB expression in COPD subjects. Respir. Res.",{"doi":2269},"10.1186\u002F1465-9921-10-24",{"id":28,"text":2271,"url":28,"identifiers":2272},"Yang, 2009, RelB is differentially regulated by IκB Kinase-α in B cells and mouse lung by cigarette smoke, Am. J. Respir. Cell Mol. Biol., 40, 147, 10.1165\u002Frcmb.2008-0207OC",{"doi":2273},"10.1165\u002Frcmb.2008-0207OC",{"id":28,"text":2275,"url":28,"identifiers":2276},"Li, Y.T., He, B., Wang, Y.Z., and Wang, J. (2009). Effects of intratracheal administration of nuclear factor-κB decoy oligodeoxynucleotides on long-term cigarette smoke-induced lung inflammation and pathology in mice. Respir. Res.",{"doi":2277},"10.1186\u002F1465-9921-10-79",{"id":28,"text":2279,"url":28,"identifiers":2280},"Rajendrasozhan, 2010, Anti-inflammatory effect of a selective IκB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke, Pulm. Pharmacol. Ther., 23, 172, 10.1016\u002Fj.pupt.2010.01.002",{"doi":2281},"10.1016\u002Fj.pupt.2010.01.002",{"id":28,"text":2283,"url":28,"identifiers":2284},"Rastrick, 2013, Cigarette smoke induced airway inflammation is independent of NF-κB signalling, PLoS ONE, 8, e54128, 10.1371\u002Fjournal.pone.0054128",{"doi":2285},"10.1371\u002Fjournal.pone.0054128",{"id":28,"text":2287,"url":28,"identifiers":2288},"Yao, 2008, Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice, Am. J. Physiol. Lung Cell. Mol. Physiol., 294, L1174, 10.1152\u002Fajplung.00439.2007",{"doi":2289},"10.1152\u002Fajplung.00439.2007",{"id":28,"text":2291,"url":28,"identifiers":2292},"Das, 2001, A critical role for NF-κB in GATA3 expression and TH2 differentiation in allergic airway inflammation, Nat. Immunol., 2, 45, 10.1038\u002F83158",{"doi":2293},"10.1038\u002F83158",{"id":28,"text":2295,"url":28,"identifiers":2296},"Coward, 2004, Allergen activates peripheral blood eosinophil nuclear factor-κB to generate granulocyte macrophage-colony stimulating factor, tumour necrosis factor-α and interleukin-8, Clin. Exp. Allergy, 34, 1071, 10.1111\u002Fj.1365-2222.2004.02003.x",{"doi":2297},"10.1111\u002Fj.1365-2222.2004.02003.x",{"id":28,"text":2299,"url":28,"identifiers":2300},"Wong, 2006, Induction of adhesion molecules upon the interaction between eosinophils and bronchial epithelial cells: Involvement of p38 MAPK and NF-κB, Int. Immunopharmacol., 6, 1859, 10.1016\u002Fj.intimp.2006.08.003",{"doi":2301},"10.1016\u002Fj.intimp.2006.08.003",{"id":28,"text":2303,"url":28,"identifiers":2304},"Langereis, 2010, Abrogation of NF-κB signaling in human neutrophils induces neutrophil survival through sustained p38-MAPK activation, J. Leukoc. Biol., 88, 655, 10.1189\u002Fjlb.0809544",{"doi":2305},"10.1189\u002Fjlb.0809544",{"id":28,"text":2307,"url":28,"identifiers":2308},"Murugan, 2009, Signal transduction pathways linking the activation of alveolar macrophages with the recruitment of neutrophils to lungs in chronic obstructive pulmonary disease, Exp. Lung Res., 35, 439, 10.1080\u002F01902140902759290",{"doi":2309},"10.1080\u002F01902140902759290",{"id":28,"text":2311,"url":28,"identifiers":2312},"Yang, 2006, Cigarette smoke induces proinflammatory cytokine release by activation of NF-κB and posttranslational modifications of histone deacetylase in macrophages, Am. J. Physiol. Lung Cell. Mol. Physiol., 291, L46, 10.1152\u002Fajplung.00241.2005",{"doi":2313},"10.1152\u002Fajplung.00241.2005",{"id":28,"text":2315,"url":28,"identifiers":2316},"Lee, 2007, Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFκB, Proc. Natl. Acad. Sci. USA, 104, 914, 10.1073\u002Fpnas.0607305104",{"doi":2317},"10.1073\u002Fpnas.0607305104",{"id":28,"text":2319,"url":28,"identifiers":2320},"Newton, 2007, Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors, J. Pharmacol. Exp. Ther., 321, 734, 10.1124\u002Fjpet.106.118125",{"doi":2321},"10.1124\u002Fjpet.106.118125",{"id":28,"text":2323,"url":28,"identifiers":2324},"Shimizu, 2012, Dehydroxymethylepoxyquinomicin (DHMEQ), a novel NF-κB inhibitor, inhibits allergic inflammation and airway remodelling in murine models of asthma, Clin. Exp. Allergy, 42, 1273, 10.1111\u002Fj.1365-2222.2012.04007.x",{"doi":2325},"10.1111\u002Fj.1365-2222.2012.04007.x",{"id":28,"text":2327,"url":28,"identifiers":2328},"Cao, 2011, Bronchial epithelial cells release IL-6, CXCL1 and CXCL8 upon mast cell interaction, Cytokine, 56, 823, 10.1016\u002Fj.cyto.2011.09.016",{"doi":2329},"10.1016\u002Fj.cyto.2011.09.016",{"id":28,"text":2331,"url":28,"identifiers":2332},"Redhu, 2011, Essential role of NF-κB and AP-1 transcription factors in TNF-α-induced TSLP expression in human airway smooth muscle cells, Am. J. Physiol. Lung Cell. Mol. Physiol., 300, L479, 10.1152\u002Fajplung.00301.2009",{"doi":2333},"10.1152\u002Fajplung.00301.2009",{"id":28,"text":2335,"url":28,"identifiers":2336},"Tirumurugaan, K.G., Kang, B.N., Panettieri, R.A., Foster, D.N., Walseth, T.F., and Kannan, M.S. (2008). Regulation of the CD38 promoter in human airway smooth muscle cells by TNF-α and dexamethasone. Respir. Res.",{"doi":2337},"10.1186\u002F1465-9921-9-26",{"id":28,"text":2339,"url":28,"identifiers":2340},"Lee, 2006, Transcriptional regulation of VCAM-1 expression by tumor necrosis factor-alpha in human tracheal smooth muscle cells: Involvement of MAPKs, NF-κB, p300, and histone acetylation, J. Cell. Physiol., 207, 174, 10.1002\u002Fjcp.20549",{"doi":2341},"10.1002\u002Fjcp.20549",{"id":28,"text":2343,"url":28,"identifiers":2344},"Catley, 2006, Validation of the anti-inflammatory properties of small-molecule IκB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle, Mol. Pharmacol., 70, 697, 10.1124\u002Fmol.106.023150",{"doi":2345},"10.1124\u002Fmol.106.023150",{"id":28,"text":2347,"url":28,"identifiers":2348},"John, 2009, Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-κB p65, C\u002FEBP β, and RNA polymerase II binding to the CXCL8 promoter, J. Immunol., 183, 4682, 10.4049\u002Fjimmunol.0803832",{"doi":2349},"10.4049\u002Fjimmunol.0803832",{"id":28,"text":2351,"url":28,"identifiers":2352},"Alrashdan, 2012, Asthmatic airway smooth muscle CXCL10 production: Mitogen-activated protein kinase JNK involvement, Am. J. Physiol. Lung Cell. Mol. Physiol., 302, L1118, 10.1152\u002Fajplung.00232.2011",{"doi":2353},"10.1152\u002Fajplung.00232.2011",{"id":28,"text":2355,"url":28,"identifiers":2356},"Gras, 2013, Bronchial epithelium as a target for innovative treatments in asthma, Pharmacol. Ther., 140, 290, 10.1016\u002Fj.pharmthera.2013.07.008",{"doi":2357},"10.1016\u002Fj.pharmthera.2013.07.008",{"id":28,"text":2359,"url":28,"identifiers":2360},"Clarke, 2010, TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein, J. Biol. Chem., 285, 29101, 10.1074\u002Fjbc.M109.099952",{"doi":2361},"10.1074\u002Fjbc.M109.099952",{"id":28,"text":2363,"url":28,"identifiers":2364},"Pelaia, G., Vatrella, A., Busceti, M.T., Gallelli, L., Calabrese, C., Terracciano, R., and Maselli, R. (2015). Cellular mechanisms underlying eosinophilic and neutrophilic airway inflammation in asthma. Mediat. Inflamm.",{"doi":2365},"10.1155\u002F2015\u002F879783",{"id":28,"text":2367,"url":28,"identifiers":2368},"Brusselle, 2013, Eosinophils in the spotlight: Eosinophilic airway inflammation in nonallergic asthma, Nat. Med., 19, 977, 10.1038\u002Fnm.3300",{"doi":2369},"10.1038\u002Fnm.3300",{"id":28,"text":2371,"url":28,"identifiers":2372},"Chien, 2013, Increased IL-17A secreting CD4+ T cells, serum IL-17 levels and exhaled nitric oxide are correlated with childhood asthma severity, Clin. Exp. Allergy, 43, 1018, 10.1111\u002Fcea.12119",{"doi":2373},"10.1111\u002Fcea.12119",{"id":28,"text":2375,"url":28,"identifiers":2376},"Chesne, 2014, IL-17 in severe asthma. Where do we stand?, Am. J. Respir. Crit. Care Med., 190, 1094, 10.1164\u002Frccm.201405-0859PP",{"doi":2377},"10.1164\u002Frccm.201405-0859PP",{"id":28,"text":2379,"url":28,"identifiers":2380},"Fujisawa, 2011, NF-κB mediates IL-1β- and IL-17A-induced MUC5B expression in airway epithelial cells, Am. J. Respir. Cell Mol. Biol., 45, 246, 10.1165\u002Frcmb.2009-0313OC",{"doi":2381},"10.1165\u002Frcmb.2009-0313OC",{"id":28,"text":2383,"url":28,"identifiers":2384},"Dragon, 2014, IL-17A mediates a selective gene expression profile in asthmatic human airway smooth muscle cells, Am. J. Respir. Cell Mol. Biol., 50, 1053, 10.1165\u002Frcmb.2012-0267OC",{"doi":2385},"10.1165\u002Frcmb.2012-0267OC",{"id":28,"text":2387,"url":28,"identifiers":2388},"Chang, 2012, Th17-associated cytokines promote human airway smooth muscle cell proliferation, FASEB J., 26, 5152, 10.1096\u002Ffj.12-208033",{"doi":2389},"10.1096\u002Ffj.12-208033",{"id":28,"text":2391,"url":28,"identifiers":2392},"Kankaanranta, 2014, Tumour necrosis factor-α regulates human eosinophil apoptosis via ligation of TNF-receptor 1 and balance between NF-κB and AP-1, PLoS ONE, 9, e90298, 10.1371\u002Fjournal.pone.0090298",{"doi":2393},"10.1371\u002Fjournal.pone.0090298",{"id":28,"text":2395,"url":28,"identifiers":2396},"Ordonez, 2000, Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance, Am. J. Respir. Crit. Care Med., 161, 1185, 10.1164\u002Fajrccm.161.4.9812061",{"doi":2397},"10.1164\u002Fajrccm.161.4.9812061",{"id":28,"text":2399,"url":28,"identifiers":2400},"Nakagome, 2012, Neutrophilic inflammation in severe asthma, Int. Arch. Allergy Immunol., 158, 96, 10.1159\u002F000337801",{"doi":2401},"10.1159\u002F000337801",{"id":28,"text":2403,"url":28,"identifiers":2404},"Pappas, 2013, The role of macrophages in obstructive airways disease: Chronic obstructive pulmonary disease and asthma, Cytokine, 64, 613, 10.1016\u002Fj.cyto.2013.09.010",{"doi":2405},"10.1016\u002Fj.cyto.2013.09.010",{"id":28,"text":2407,"url":28,"identifiers":2408},"Cundall, 2003, Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids, J. Allergy Clin. Immunol., 112, 1064, 10.1016\u002Fj.jaci.2003.08.013",{"doi":2409},"10.1016\u002Fj.jaci.2003.08.013",{"id":28,"text":2411,"url":28,"identifiers":2412},"Wang, 2005, Induction of IL-6 in co-culture of bronchial epithelial cells and eosinophils is regulated by p38 MAPK and NF-κB, Allergy, 60, 1378, 10.1111\u002Fj.1398-9995.2005.00884.x",{"doi":2413},"10.1111\u002Fj.1398-9995.2005.00884.x",{"id":28,"text":2415,"url":28,"identifiers":2416},"Kang, 2015, S100A8, S100A9 and S100A12 activate airway epithelial cells to produce MUC5AC via extracellular signal-regulated kinase and nuclear factor-κB pathways, Immunology, 144, 79, 10.1111\u002Fimm.12352",{"doi":2417},"10.1111\u002Fimm.12352",{"id":28,"text":2419,"url":28,"identifiers":2420},"James, 2007, Clinical relevance of airway remodelling in airway diseases, Eur. Respir. J., 30, 134, 10.1183\u002F09031936.00146905",{"doi":2421},"10.1183\u002F09031936.00146905",{"id":28,"text":2423,"url":28,"identifiers":2424},"Amin, 2000, Inflammation and structural changes in the airways of patients with atopic and nonatopic asthma. BHR Group, Am. J. Respir. Crit. Care Med., 162, 2295, 10.1164\u002Fajrccm.162.6.9912001",{"doi":2425},"10.1164\u002Fajrccm.162.6.9912001",{"id":28,"text":2427,"url":28,"identifiers":2428},"Gosselink, 2010, Differential expression of tissue repair genes in the pathogenesis of chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med., 181, 1329, 10.1164\u002Frccm.200812-1902OC",{"doi":2429},"10.1164\u002Frccm.200812-1902OC",{"id":28,"text":2431,"url":28,"identifiers":2432},"Xia, 2013, Pro-inflammatory and immunomodulatory functions of airway smooth muscle: Emerging concepts, Pulm. Pharmacol. Ther., 26, 64, 10.1016\u002Fj.pupt.2012.05.006",{"doi":2433},"10.1016\u002Fj.pupt.2012.05.006",{"id":28,"text":2435,"url":28,"identifiers":2436},"Tran, 2005, Stimulus-dependent glucocorticoid-resistance of GM-CSF production in human cultured airway smooth muscle, Br. J. Pharmacol., 145, 123, 10.1038\u002Fsj.bjp.0706174",{"doi":2437},"10.1038\u002Fsj.bjp.0706174",{"id":28,"text":2439,"url":28,"identifiers":2440},"Keenan, 2012, Glucocorticoid-resistant asthma and novel anti-inflammatory drugs, Drug Discov. Today, 17, 1031, 10.1016\u002Fj.drudis.2012.05.011",{"doi":2441},"10.1016\u002Fj.drudis.2012.05.011",{"id":28,"text":2443,"url":28,"identifiers":2444},"Salem, 2012, Transforming growth factor-β impairs glucocorticoid activity in the A549 lung adenocarcinoma cell line, Br. J. Pharmacol., 166, 2036, 10.1111\u002Fj.1476-5381.2012.01885.x",{"doi":2445},"10.1111\u002Fj.1476-5381.2012.01885.x",{"id":28,"text":2447,"url":28,"identifiers":2448},"Langenbach, 2007, Resistance of fibrogenic responses to glucocorticoid and 2-methoxyestradiol in bleomycin-induced lung fibrosis in mice, Can. J. Physiol. Pharmacol., 85, 727, 10.1139\u002FY07-065",{"doi":2449},"10.1139\u002FY07-065",{"id":28,"text":2451,"url":28,"identifiers":2452},"Bonacci, 2006, Collagen impairs glucocorticoid actions in airway smooth muscle through integrin signalling, Br. J. Pharmacol., 149, 365, 10.1038\u002Fsj.bjp.0706881",{"doi":2453},"10.1038\u002Fsj.bjp.0706881",{"id":28,"text":2455,"url":28,"identifiers":2456},"Barnes, 2013, Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease, J. Allergy Clin. Immunol., 131, 636, 10.1016\u002Fj.jaci.2012.12.1564",{"doi":2457},"10.1016\u002Fj.jaci.2012.12.1564",{"id":28,"text":2459,"url":28,"identifiers":2460},"Adcock, 2005, Redox regulation of histone deacetylases and glucocorticoid-mediated inhibition of the inflammatory response, Antioxid. Redox Signal., 7, 144, 10.1089\u002Fars.2005.7.144",{"doi":2461},"10.1089\u002Fars.2005.7.144",{"id":28,"text":2463,"url":28,"identifiers":2464},"Kagoshima, 2001, Glucocorticoid-mediated transrepression is regulated by histone acetylation and DNA methylation, Eur. J. Pharmacol., 429, 327, 10.1016\u002FS0014-2999(01)01332-2",{"doi":2465},"10.1016\u002FS0014-2999(01)01332-2",{"id":28,"text":2467,"url":28,"identifiers":2468},"Ito, 2006, Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression, J. Exp. Med., 203, 7, 10.1084\u002Fjem.20050466",{"doi":2469},"10.1084\u002Fjem.20050466",{"id":28,"text":2471,"url":28,"identifiers":2472},"Rajendrasozhan, 2008, SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med., 177, 861, 10.1164\u002Frccm.200708-1269OC",{"doi":2473},"10.1164\u002Frccm.200708-1269OC",{"id":28,"text":2475,"url":28,"identifiers":2476},"Chen, 2014, SIRT4 inhibits cigarette smoke extracts-induced mononuclear cell adhesion to human pulmonary microvascular endothelial cells via regulating NF-κB activity, Toxicol. Lett., 226, 320, 10.1016\u002Fj.toxlet.2014.02.022",{"doi":2477},"10.1016\u002Fj.toxlet.2014.02.022",{"id":28,"text":2479,"url":28,"identifiers":2480},"Keenan, 2015, Pro-inflammatory mediators increase levels of the noncoding RNA GAS5 in airway smooth muscle and epithelial cells, Can. J. Physiol. Pharmacol., 93, 203, 10.1139\u002Fcjpp-2014-0391",{"doi":2481},"10.1139\u002Fcjpp-2014-0391",{"id":28,"text":2483,"url":28,"identifiers":2484},"Eddleston, 2007, The anti-inflammatory effect of glucocorticoids is mediated by glucocorticoid-induced leucine zipper in epithelial cells, J. Allergy Clin. Immunol., 119, 115, 10.1016\u002Fj.jaci.2006.08.027",{"doi":2485},"10.1016\u002Fj.jaci.2006.08.027",{"id":28,"text":2487,"url":28,"identifiers":2488},"Ayroldi, 2001, Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor κB, Blood, 98, 743, 10.1182\u002Fblood.V98.3.743",{"doi":2489},"10.1182\u002Fblood.V98.3.743",{"id":28,"text":2491,"url":28,"identifiers":2492},"Che, 2012, Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells, Biochim. Biophys. Acta, 1823, 1658, 10.1016\u002Fj.bbamcr.2012.06.011",{"doi":2493},"10.1016\u002Fj.bbamcr.2012.06.011",{"id":28,"text":2495,"url":28,"identifiers":2496},"Manetsch, 2012, MKP-1: A negative feedback effector that represses MAPK-mediated pro-inflammatory signaling pathways and cytokine secretion in human airway smooth muscle cells, Cell Signal., 24, 907, 10.1016\u002Fj.cellsig.2011.12.013",{"doi":2497},"10.1016\u002Fj.cellsig.2011.12.013",{"id":28,"text":2499,"url":28,"identifiers":2500},"King, 2009, Inhibition of NF-κB-dependent transcription by MKP-1: Transcriptional repression by glucocorticoids occurring via p38 MAPK, J. Biol. Chem., 284, 26803, 10.1074\u002Fjbc.M109.028381",{"doi":2501},"10.1074\u002Fjbc.M109.028381",{"id":28,"text":2503,"url":28,"identifiers":2504},"Ziegelbauer, 2005, A selective novel low-molecular-weight inhibitor of IκB kinase-β (IKK-β) prevents pulmonary inflammation and shows broad anti-inflammatory activity, Br. J. Pharmacol., 145, 178, 10.1038\u002Fsj.bjp.0706176",{"doi":2505},"10.1038\u002Fsj.bjp.0706176",{"id":28,"text":2507,"url":28,"identifiers":2508},"Sugita, 2009, Antiallergic and anti-inflammatory effects of a novel IκB kinase beta inhibitor, IMD-0354, in a mouse model of allergic inflammation, Int. Arch. Allergy Immunol., 148, 186, 10.1159\u002F000161579",{"doi":2509},"10.1159\u002F000161579",{"id":28,"text":2511,"url":28,"identifiers":2512},"Ogawa, 2011, IκB kinase beta inhibitor IMD-0354 suppresses airway remodelling in a Dermatophagoides pteronyssinus-sensitized mouse model of chronic asthma, Clin. Exp. Allergy, 41, 104, 10.1111\u002Fj.1365-2222.2010.03564.x",{"doi":2513},"10.1111\u002Fj.1365-2222.2010.03564.x",{"id":28,"text":2515,"url":28,"identifiers":2516},"Sommers, 2009, Novel tight-binding inhibitory factor-κB kinase (IKK-2) inhibitors demonstrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation, J. Pharmacol. Exp. Ther., 330, 377, 10.1124\u002Fjpet.108.147538",{"doi":2517},"10.1124\u002Fjpet.108.147538",{"id":28,"text":2519,"url":28,"identifiers":2520},"Kobayashi, 2013, A novel macrolide\u002Ffluoroketolide, solithromycin (CEM-101), reverses corticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition, Br. J. Pharmacol., 169, 1024, 10.1111\u002Fbph.12187",{"doi":2521},"10.1111\u002Fbph.12187",{"id":28,"text":2523,"url":28,"identifiers":2524},"To, 2010, Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med., 182, 897, 10.1164\u002Frccm.200906-0937OC",{"doi":2525},"10.1164\u002Frccm.200906-0937OC",{"id":28,"text":2527,"url":28,"identifiers":2528},"Mercado, 2011, Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-delta, J. Pharmacol. Exp. Ther., 337, 465, 10.1124\u002Fjpet.110.175950",{"doi":2529},"10.1124\u002Fjpet.110.175950",{"id":28,"text":2531,"url":28,"identifiers":2532},"Rossios, 2012, Corticosteroid insensitivity is reversed by formoterol via phosphoinositide-3-kinase inhibition, Br. J. Pharmacol., 167, 775, 10.1111\u002Fj.1476-5381.2012.01864.x",{"doi":2533},"10.1111\u002Fj.1476-5381.2012.01864.x",{"id":28,"text":2535,"url":28,"identifiers":2536},"Kobayashi, 2013, A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition, J. Pharmacol. Exp. Ther., 345, 76, 10.1124\u002Fjpet.112.200733",{"doi":2537},"10.1124\u002Fjpet.112.200733",{"id":28,"text":2539,"url":28,"identifiers":2540},"Li, 2012, Effect of erythromycin on cigarette-induced histone deacetylase protein expression and nuclear factor-κB activity in human macrophages in vitro, Int. Immunopharmacol., 12, 643, 10.1016\u002Fj.intimp.2011.12.022",{"doi":2541},"10.1016\u002Fj.intimp.2011.12.022",{"id":28,"text":2543,"url":28,"identifiers":2544},"Lee, 2006, Phosphoinositide 3-kinase-delta inhibitor reduces vascular permeability in a murine model of asthma, J. Allergy Clin. Immunol., 118, 403, 10.1016\u002Fj.jaci.2006.04.041",{"doi":2545},"10.1016\u002Fj.jaci.2006.04.041",{"id":28,"text":2547,"url":28,"identifiers":2548},"Collison, 2013, Inhibiting AKT phosphorylation employing non-cytotoxic anthraquinones ameliorates TH2 mediated allergic airways disease and rhinovirus exacerbation, PLoS ONE, 8, e79565, 10.1371\u002Fjournal.pone.0079565",{"doi":2549},"10.1371\u002Fjournal.pone.0079565",{"id":28,"text":2551,"url":28,"identifiers":2552},"Choi, 2013, Inhibition of protein kinase C delta attenuates allergic airway inflammation through suppression of PI3K\u002FAkt\u002FmTOR\u002FHIF-1 alpha\u002FVEGF pathway, PLoS ONE, 8, e81773, 10.1371\u002Fjournal.pone.0081773",{"doi":2553},"10.1371\u002Fjournal.pone.0081773",{"id":28,"text":2555,"url":28,"identifiers":2556},"Kim, 2010, Involvement of sirtuin 1 in airway inflammation and hyperresponsiveness of allergic airway disease, J. Allergy Clin. Immunol., 125, 449.e14, 10.1016\u002Fj.jaci.2009.08.009",{"doi":2557},"10.1016\u002Fj.jaci.2009.08.009",{"id":28,"text":2559,"url":28,"identifiers":2560},"Chen, 2015, Therapeutic effects of resveratrol in a mouse model of HDM-induced allergic asthma, Int. Immunopharmacol., 25, 43, 10.1016\u002Fj.intimp.2015.01.013",{"doi":2561},"10.1016\u002Fj.intimp.2015.01.013",{"id":28,"text":2563,"url":28,"identifiers":2564},"Ichikawa, 2013, Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma, Respirology, 18, 332, 10.1111\u002Fj.1440-1843.2012.02284.x",{"doi":2565},"10.1111\u002Fj.1440-1843.2012.02284.x",{"id":28,"text":2567,"url":28,"identifiers":2568},"Royce, S.G., Dang, W., Yuan, G., Tran, J., el Osta, A., Karagiannis, T.C., and Tang, M.L. (2011). Resveratrol has protective effects against airway remodeling and airway hyperreactivity in a murine model of allergic airways disease. Pathobiol. Aging Age Relat. Dis.",{"doi":2569},"10.3402\u002FPBA.v1i0.7134",{"id":28,"text":2571,"url":28,"identifiers":2572},"Lee, 2009, Anti-inflammatory and anti-asthmatic effects of resveratrol, a polyphenolic stilbene, in a mouse model of allergic asthma, Int. Immunopharmacol., 9, 418, 10.1016\u002Fj.intimp.2009.01.005",{"doi":2573},"10.1016\u002Fj.intimp.2009.01.005",{"id":28,"text":2575,"url":28,"identifiers":2576},"Yao, 2012, SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice, J. Clin. Invest., 122, 2032, 10.1172\u002FJCI60132",{"doi":2577},"10.1172\u002FJCI60132",{"id":28,"text":2579,"url":28,"identifiers":2580},"Yao, 2014, SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism, Am. J. Physiol. Lung Cell. Mol. Physiol., 306, L816, 10.1152\u002Fajplung.00323.2013",{"doi":2581},"10.1152\u002Fajplung.00323.2013",{"id":2583,"createTime":2584,"updateTime":2584,"relativeEntities":2585,"slug":2586,"properties":2587,"entityType":972,"verifyStatus":26,"verifyTime":2584,"verifyNote":973,"languages":2602,"translateLanguages":28,"viewCount":32,"primaryUrl":2603,"fullTextUrl":28,"authors":2604,"publicationType":1209,"publisherRelationship":2643,"citationCount":2696,"citationInfo":2697,"publishDate":28,"publishYear":28,"citationAnalyzeStatus":881,"lastCitationAnalyze":28,"indexDatabases":2699,"openAccess":28,"references":2700,"isForceReanalyzing":2008},"7429fd37-2f0b-4c86-ac0c-55cddef673a4","2025-01-01T21:30:29.253+00:00",[],"Impact-of-Oxidative-Stress-on-Exercising-Skeletal-Muscle",{"mag":2588,"pmc":2590,"openalex":2592,"abstract":2594,"title":2596,"pm":2598,"doi":2600},{"VOID":2589},"2037055992",{"VOID":2591},"4496677",{"VOID":2593},"W2037055992",{"EN":2595},"\u003Cjats:p>It is well established that muscle contractions during exercise lead to elevated levels of reactive oxygen species (ROS) in skeletal muscle. These highly reactive molecules have many deleterious effects, such as a reduction of force generation and increased muscle atrophy. Since the discovery of exercise-induced oxidative stress several decades ago, evidence has accumulated that ROS produced during exercise also have positive effects by influencing cellular processes that lead to increased expression of antioxidants. These molecules are particularly elevated in regularly exercising muscle to prevent the negative effects of ROS by neutralizing the free radicals. In addition, ROS also seem to  be involved in the exercise-induced adaptation of the muscle phenotype. This review provides an overview of the evidences to date on the effects of ROS in exercising muscle. These aspects include the sources of ROS, their positive and negative cellular effects, the role of antioxidants, and the present evidence on ROS-dependent adaptations of muscle cells  in response to physical exercise.\u003C\u002Fjats:p>",{"EN":2597},"Impact of Oxidative Stress on Exercising Skeletal 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1978, Effects of exercise, vitamin E, and ozone on pulmonary function and lipid peroxidation, J. Appl. Physiol. Respir. Environ. Exerc. Physiol., 45, 927",{},{"id":28,"text":2705,"url":28,"identifiers":2706},"Davies, 1982, Free radicals and tissue damage produced by exercise, Biochem. Biophys. Res. Commun., 107, 1198, 10.1016\u002FS0006-291X(82)80124-1",{"doi":2707},"10.1016\u002FS0006-291X(82)80124-1",{"id":28,"text":2709,"url":28,"identifiers":2710},"Vollaard, 2005, Exercise-induced oxidative stress: Myths, realities and physiological relevance, Sports Med., 35, 1045, 10.2165\u002F00007256-200535120-00004",{"doi":2711},"10.2165\u002F00007256-200535120-00004",{"id":28,"text":2713,"url":28,"identifiers":2714},"Fisher-Wellman, K., and Bloomer, R.J. (2009). Acute exercise and oxidative stress: A 30 year history. Dyn. Med.",{"doi":2715},"10.1186\u002F1476-5918-8-1",{"id":28,"text":2717,"url":28,"identifiers":2718},"Sahlin, 2010, Ultraendurance exercise increases the production of reactive oxygen species in isolated mitochondria from human skeletal muscle, J. Appl. Physiol., 108, 780, 10.1152\u002Fjapplphysiol.00966.2009",{"doi":2719},"10.1152\u002Fjapplphysiol.00966.2009",{"id":28,"text":2721,"url":28,"identifiers":2722},"Vind, 2010, Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes, Diabetologia, 53, 1976, 10.1007\u002Fs00125-010-1813-x",{"doi":2723},"10.1007\u002Fs00125-010-1813-x",{"id":28,"text":2725,"url":28,"identifiers":2726},"Ghosh, 2011, Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance, Diabetes, 60, 2051, 10.2337\u002Fdb11-0121",{"doi":2727},"10.2337\u002Fdb11-0121",{"id":28,"text":2729,"url":28,"identifiers":2730},"Powers, 2008, Exercise-induced oxidative stress: Cellular mechanisms and impact on muscle force production, Physiol. Rev., 88, 1243, 10.1152\u002Fphysrev.00031.2007",{"doi":2731},"10.1152\u002Fphysrev.00031.2007",{"id":28,"text":2733,"url":28,"identifiers":2734},"Peake, 2004, Neutrophil activation, antioxidant supplements and exercise-induced oxidative stress, Exerc. Immunol. Rev., 10, 129",{},{"id":28,"text":2736,"url":28,"identifiers":2737},"Moylan, 2007, Oxidative stress, chronic disease, and muscle wasting, Muscle Nerve, 35, 411, 10.1002\u002Fmus.20743",{"doi":2738},"10.1002\u002Fmus.20743",{"id":28,"text":2740,"url":28,"identifiers":2741},"Gomes, 2012, Oxidants, antioxidants, and the beneficial roles of exercise-induced production of reactive species, Oxid. Med. Cell Longev., 2012, 756132, 10.1155\u002F2012\u002F756132",{"doi":2742},"10.1155\u002F2012\u002F756132",{"id":28,"text":2744,"url":28,"identifiers":2745},"Duarte, 1993, Endothelium-derived oxidative stress may contribute to exercise-induced muscle damage, Int. J. Sports Med., 14, 440, 10.1055\u002Fs-2007-1021207",{"doi":2746},"10.1055\u002Fs-2007-1021207",{"id":28,"text":2748,"url":28,"identifiers":2749},"Murphy, 2009, How mitochondria produce reactive oxygen species, Biochem. J., 417, 1, 10.1042\u002FBJ20081386",{"doi":2750},"10.1042\u002FBJ20081386",{"id":28,"text":2752,"url":28,"identifiers":2753},"Brand, 2010, The sites and topology of mitochondrial superoxide production, Exp. Gerontol., 45, 466, 10.1016\u002Fj.exger.2010.01.003",{"doi":2754},"10.1016\u002Fj.exger.2010.01.003",{"id":28,"text":2756,"url":28,"identifiers":2757},"Buckingham, 2002, Topology of superoxide production from different sites in the mitochondrial electron transport chain, J. Biol. Chem., 277, 44784, 10.1074\u002Fjbc.M207217200",{"doi":2758},"10.1074\u002Fjbc.M207217200",{"id":28,"text":2760,"url":28,"identifiers":2761},"Perevoshchikova, 2013, Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria, Free Radic. Biol. Med., 61, 298, 10.1016\u002Fj.freeradbiomed.2013.04.006",{"doi":2762},"10.1016\u002Fj.freeradbiomed.2013.04.006",{"id":28,"text":2764,"url":28,"identifiers":2765},"Goncalves, 2014, Production of superoxide\u002FH2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria, Free Radic. Biol. Med., 72, 149, 10.1016\u002Fj.freeradbiomed.2014.04.007",{"doi":2766},"10.1016\u002Fj.freeradbiomed.2014.04.007",{"id":28,"text":2768,"url":28,"identifiers":2769},"Barja, 1999, Mitochondrial oxygen radical generation and leak: Sites of production in states 4 and 3, organ specificity, and relation to aging and longevity, J. Bioenerg. Biomembr., 31, 347, 10.1023\u002FA:1005427919188",{"doi":2770},"10.1023\u002FA:1005427919188",{"id":28,"text":2772,"url":28,"identifiers":2773},"Muller, 2004, Complex III releases superoxide to both sides of the inner mitochondrial membrane, J. Biol. Chem., 279, 49064, 10.1074\u002Fjbc.M407715200",{"doi":2774},"10.1074\u002Fjbc.M407715200",{"id":28,"text":2776,"url":28,"identifiers":2777},"Goncalves, 2015, Sites of superoxide and hydrogen peroxide production by muscle mitochondria assessed ex vivo under conditions mimicking rest and exercise, J. Biol. Chem., 290, 209, 10.1074\u002Fjbc.M114.619072",{"doi":2778},"10.1074\u002Fjbc.M114.619072",{"id":28,"text":2780,"url":28,"identifiers":2781},"Bedard, 2007, The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology, Physiol. Rev., 87, 245, 10.1152\u002Fphysrev.00044.2005",{"doi":2782},"10.1152\u002Fphysrev.00044.2005",{"id":28,"text":2784,"url":28,"identifiers":2785},"Brandes, 2014, Nox family NADPH oxidases: Molecular mechanisms of activation, Free Radic. Biol. Med., 76, 208, 10.1016\u002Fj.freeradbiomed.2014.07.046",{"doi":2786},"10.1016\u002Fj.freeradbiomed.2014.07.046",{"id":28,"text":2788,"url":28,"identifiers":2789},"Xia, 2003, Skeletal muscle sarcoplasmic reticulum contains a NADH-dependent oxidase that generates superoxide, Am. J. Physiol. Cell Physiol., 285, C215, 10.1152\u002Fajpcell.00034.2002",{"doi":2790},"10.1152\u002Fajpcell.00034.2002",{"id":28,"text":2792,"url":28,"identifiers":2793},"Shkryl, 2009, Reciprocal amplification of ROS and Ca2+ signals in stressed mdx dystrophic skeletal muscle fibers, Pflugers Arch., 458, 915, 10.1007\u002Fs00424-009-0670-2",{"doi":2794},"10.1007\u002Fs00424-009-0670-2",{"id":28,"text":2796,"url":28,"identifiers":2797},"Sakellariou, 2013, Studies of mitochondrial and nonmitochondrial sources implicate nicotinamide adenine dinucleotide phosphate oxidase(s) in the increased skeletal muscle superoxide generation that occurs during contractile activity, Antioxid. Redox Signal., 18, 603, 10.1089\u002Fars.2012.4623",{"doi":2798},"10.1089\u002Fars.2012.4623",{"id":28,"text":2800,"url":28,"identifiers":2801},"Cherednichenko, 2004, NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release, Circ. Res., 94, 478, 10.1161\u002F01.RES.0000115554.65513.7C",{"doi":2802},"10.1161\u002F01.RES.0000115554.65513.7C",{"id":28,"text":2804,"url":28,"identifiers":2805},"Espinosa, 2006, Myotube depolarization generates reactive oxygen species through NAD(P)H oxidase; ROS-elicited Ca2+ stimulates ERK, CREB, early genes, J. Cell Physiol., 209, 379, 10.1002\u002Fjcp.20745",{"doi":2806},"10.1002\u002Fjcp.20745",{"id":28,"text":2808,"url":28,"identifiers":2809},"Hidalgo, 2006, A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S-glutathionylation, J. Biol. Chem., 281, 26473, 10.1074\u002Fjbc.M600451200",{"doi":2810},"10.1074\u002Fjbc.M600451200",{"id":28,"text":2812,"url":28,"identifiers":2813},"Espinosa, 2009, NADPH oxidase and hydrogen peroxide mediate insulin-induced calcium increase in skeletal muscle cells, J. Biol. Chem., 284, 2568, 10.1074\u002Fjbc.M804249200",{"doi":2814},"10.1074\u002Fjbc.M804249200",{"id":28,"text":2816,"url":28,"identifiers":2817},"Harrison, 2002, Structure and function of xanthine oxidoreductase: Where are we now?, Free Radic. Biol. Med., 33, 774, 10.1016\u002FS0891-5849(02)00956-5",{"doi":2818},"10.1016\u002FS0891-5849(02)00956-5",{"id":28,"text":2820,"url":28,"identifiers":2821},"Judge, 2004, Xanthine oxidase and activated neutrophils cause oxidative damage to skeletal muscle after contractile claudication, Am. J. Physiol. Heart Circ. Physiol., 286, H252, 10.1152\u002Fajpheart.00684.2003",{"doi":2822},"10.1152\u002Fajpheart.00684.2003",{"id":28,"text":2824,"url":28,"identifiers":2825},"Zhao, 2013, Oxygen consumption and usage during physical exercise: The balance between oxidative stress and ROS-dependent adaptive signaling, Antioxid. Redox Signal., 18, 1208, 10.1089\u002Fars.2011.4498",{"doi":2826},"10.1089\u002Fars.2011.4498",{"id":28,"text":2828,"url":28,"identifiers":2829},"Kang, 2013, Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: Role of PGC-1α, Exp. Gerontol., 48, 1343, 10.1016\u002Fj.exger.2013.08.004",{"doi":2830},"10.1016\u002Fj.exger.2013.08.004",{"id":28,"text":2832,"url":28,"identifiers":2833},"Sriram, 2011, Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF-κB, Aging Cell, 10, 931, 10.1111\u002Fj.1474-9726.2011.00734.x",{"doi":2834},"10.1111\u002Fj.1474-9726.2011.00734.x",{"id":28,"text":2836,"url":28,"identifiers":2837},"Sriram, 2014, Myostatin augments muscle-specific ring finger protein-1 expression through an NF-κB independent mechanism in SMAD3 null muscle, Mol. Endocrinol., 28, 317, 10.1210\u002Fme.2013-1179",{"doi":2838},"10.1210\u002Fme.2013-1179",{"id":28,"text":2840,"url":28,"identifiers":2841},"Zuo, 2004, Lipoxygenase-dependent superoxide release in skeletal muscle, J. Appl. Physiol., 97, 661, 10.1152\u002Fjapplphysiol.00096.2004",{"doi":2842},"10.1152\u002Fjapplphysiol.00096.2004",{"id":28,"text":2844,"url":28,"identifiers":2845},"Zhao, 2002, Cytosolic phospholipase A2 (cPLA2) regulation of human monocyte NADPH oxidase activity. cPLA2 affects translocation but not phosphorylation of p67(phox) and p47(phox), J. Biol. Chem., 277, 25385, 10.1074\u002Fjbc.M203630200",{"doi":2846},"10.1074\u002Fjbc.M203630200",{"id":28,"text":2848,"url":28,"identifiers":2849},"Jaburek, 2010, Mitochondrial phospholipase A2 activated by reactive oxygen species in heart mitochondria induces mild uncoupling, Physiol. Res., 59, 737",{},{"id":28,"text":2851,"url":28,"identifiers":2852},"Gong, 2006, Calcium-independent phospholipase A2 modulates cytosolic oxidant activity and contractile function in murine skeletal muscle cells, J. Appl. Physiol., 100, 399, 10.1152\u002Fjapplphysiol.00873.2005",{"doi":2853},"10.1152\u002Fjapplphysiol.00873.2005",{"id":28,"text":2855,"url":28,"identifiers":2856},"Smith, 2006, Redox modulation of contractile function in respiratory and limb skeletal muscle, Respir. Physiol. Neurobiol., 151, 229, 10.1016\u002Fj.resp.2005.12.011",{"doi":2857},"10.1016\u002Fj.resp.2005.12.011",{"id":28,"text":2859,"url":28,"identifiers":2860},"Taylor, 2001, Adaptation to exercise-induced oxidative stress: From muscle to brain, Exerc. Immunol. Rev., 7, 90",{},{"id":28,"text":2862,"url":28,"identifiers":2863},"Reid, 2008, Free radicals and muscle fatigue: Of ROS, canaries, and the IOC, Free Radic. Biol. Med., 44, 169, 10.1016\u002Fj.freeradbiomed.2007.03.002",{"doi":2864},"10.1016\u002Fj.freeradbiomed.2007.03.002",{"id":28,"text":2866,"url":28,"identifiers":2867},"Allen, 2008, Skeletal muscle fatigue: Cellular mechanisms, Physiol. Rev., 88, 287, 10.1152\u002Fphysrev.00015.2007",{"doi":2868},"10.1152\u002Fphysrev.00015.2007",{"id":28,"text":2870,"url":28,"identifiers":2871},"Lamb, 2011, Acute effects of reactive oxygen and nitrogen species on the contractile function of skeletal muscle, J. Physiol., 589, 2119, 10.1113\u002Fjphysiol.2010.199059",{"doi":2872},"10.1113\u002Fjphysiol.2010.199059",{"id":28,"text":2874,"url":28,"identifiers":2875},"Lamb, 2003, Effects of oxidation and reduction on contractile function in skeletal muscle fibres of the rat, J. Physiol., 546, 149, 10.1113\u002Fjphysiol.2002.027896",{"doi":2876},"10.1113\u002Fjphysiol.2002.027896",{"id":28,"text":2878,"url":28,"identifiers":2879},"Posterino, 2003, Effects of oxidation and cytosolic redox conditions on excitation-contraction coupling in rat skeletal muscle, J. Physiol., 547, 807, 10.1113\u002Fjphysiol.2002.035204",{"doi":2880},"10.1113\u002Fjphysiol.2002.035204",{"id":28,"text":2882,"url":28,"identifiers":2883},"Cheng, 2015, Antioxidant treatments do not improve force recovery after fatiguing stimulation of mouse skeletal muscle fibres, J. Physiol., 593, 457, 10.1113\u002Fjphysiol.2014.279398",{"doi":2884},"10.1113\u002Fjphysiol.2014.279398",{"id":28,"text":2886,"url":28,"identifiers":2887},"Andrade, 1998, Effect of hydrogen peroxide and dithiothreitol on contractile function of single skeletal muscle fibres from the mouse, J. Physiol., 509, 565, 10.1111\u002Fj.1469-7793.1998.565bn.x",{"doi":2888},"10.1111\u002Fj.1469-7793.1998.565bn.x",{"id":28,"text":2890,"url":28,"identifiers":2891},"Prochniewicz, 2008, Changes in actin structural transitions associated with oxidative inhibition of muscle contraction, Biochemistry, 47, 11811, 10.1021\u002Fbi801080x",{"doi":2892},"10.1021\u002Fbi801080x",{"id":28,"text":2894,"url":28,"identifiers":2895},"Mollica, 2012, S-glutathionylation of troponin I (fast) increases contractile apparatus Ca2+ sensitivity in fast-twitch muscle fibres of rats and humans, J. Physiol., 590, 1443, 10.1113\u002Fjphysiol.2011.224535",{"doi":2896},"10.1113\u002Fjphysiol.2011.224535",{"id":28,"text":2898,"url":28,"identifiers":2899},"Jackson, 2002, Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function, Mol. Aspects Med., 23, 209, 10.1016\u002FS0098-2997(02)00018-3",{"doi":2900},"10.1016\u002FS0098-2997(02)00018-3",{"id":28,"text":2902,"url":28,"identifiers":2903},"Gumucio, 2013, Atrogin-1, MuRF-1, and sarcopenia, Endocrine, 43, 12, 10.1007\u002Fs12020-012-9751-7",{"doi":2904},"10.1007\u002Fs12020-012-9751-7",{"id":28,"text":2906,"url":28,"identifiers":2907},"Witt, 2005, MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: Towards understanding MURF-dependent muscle ubiquitination, J. Mol. Biol., 350, 713, 10.1016\u002Fj.jmb.2005.05.021",{"doi":2908},"10.1016\u002Fj.jmb.2005.05.021",{"id":28,"text":2910,"url":28,"identifiers":2911},"Cohen, 2009, During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation, J. Cell Biol., 185, 1083, 10.1083\u002Fjcb.200901052",{"doi":2912},"10.1083\u002Fjcb.200901052",{"id":28,"text":2914,"url":28,"identifiers":2915},"Ji, 1999, Antioxidants and oxidative stress in exercise, Proc. Soc. Exp. Biol. Med., 222, 283, 10.1046\u002Fj.1525-1373.1999.d01-145.x",{"doi":2916},"10.1046\u002Fj.1525-1373.1999.d01-145.x",{"id":28,"text":2918,"url":28,"identifiers":2919},"Smith, 1996, Compartmentation of glutathione: Implications for the study of toxicity and disease, Toxicol. Appl. Pharmacol., 140, 1, 10.1006\u002Ftaap.1996.0191",{"doi":2920},"10.1006\u002Ftaap.1996.0191",{"id":28,"text":2922,"url":28,"identifiers":2923},"Hayes, 2005, Glutathione transferases, Ann. Rev. Pharmacol. Toxicol., 45, 51, 10.1146\u002Fannurev.pharmtox.45.120403.095857",{"doi":2924},"10.1146\u002Fannurev.pharmtox.45.120403.095857",{"id":28,"text":2926,"url":28,"identifiers":2927},"Meister, 1983, Glutathione, Annu. Rev. Biochem., 52, 711, 10.1146\u002Fannurev.bi.52.070183.003431",{"doi":2928},"10.1146\u002Fannurev.bi.52.070183.003431",{"id":28,"text":2930,"url":28,"identifiers":2931},"Halliwell, B., and Gutteridge, J. (2007). Free Radicals in Biology and Medicine, Oxford University Press.",{},{"id":28,"text":2933,"url":28,"identifiers":2934},"Bellomo, 1987, Formation and reduction of glutathione-protein mixed disulfides during oxidative stress. A study with isolated hepatocytes and menadione (2-methyl-1,4-naphthoquinone), Biochem. Pharmacol., 36, 1313, 10.1016\u002F0006-2952(87)90087-6",{"doi":2935},"10.1016\u002F0006-2952(87)90087-6",{"id":28,"text":2937,"url":28,"identifiers":2938},"Ji, 1992, Glutathione and antioxidant enzymes in skeletal muscle: Effects of fiber type and exercise intensity, J. Appl. Physiol., 73, 1854, 10.1152\u002Fjappl.1992.73.5.1854",{"doi":2939},"10.1152\u002Fjappl.1992.73.5.1854",{"id":28,"text":2941,"url":28,"identifiers":2942},"Lew, 1985, Changes in the glutathione status of plasma, liver and muscle following exhaustive exercise in rats, FEBS Lett., 185, 262, 10.1016\u002F0014-5793(85)80919-4",{"doi":2943},"10.1016\u002F0014-5793(85)80919-4",{"id":28,"text":2945,"url":28,"identifiers":2946},"Marin, 1993, Enzymes of glutathione synthesis in dog skeletal muscles and their response to training, Acta Physiol. Scand., 147, 369, 10.1111\u002Fj.1748-1716.1993.tb09513.x",{"doi":2947},"10.1111\u002Fj.1748-1716.1993.tb09513.x",{"id":28,"text":2949,"url":28,"identifiers":2950},"Leeuwenburgh, 1997, Adaptations of glutathione antioxidant system to endurance training are tissue and muscle fiber specific, Am. J. Physiol., 272, R363",{},{"id":28,"text":2952,"url":28,"identifiers":2953},"Ji, 1995, Exercise and oxidative stress: Role of the cellular antioxidant systems, Exerc. Sport Sci. Rev., 23, 135, 10.1249\u002F00003677-199500230-00007",{"doi":2954},"10.1249\u002F00003677-199500230-00007",{"id":28,"text":2956,"url":28,"identifiers":2957},"Sen, 1995, Oxidants and antioxidants in exercise, J. Appl. Physiol., 79, 675, 10.1152\u002Fjappl.1995.79.3.675",{"doi":2958},"10.1152\u002Fjappl.1995.79.3.675",{"id":28,"text":2960,"url":28,"identifiers":2961},"Mattox, 2013, Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle, J. Physiol., 591, 3471, 10.1113\u002Fjphysiol.2013.254193",{"doi":2962},"10.1113\u002Fjphysiol.2013.254193",{"id":28,"text":2964,"url":28,"identifiers":2965},"Ji, 2008, Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling, Free Radic. Biol. Med., 44, 142, 10.1016\u002Fj.freeradbiomed.2007.02.031",{"doi":2966},"10.1016\u002Fj.freeradbiomed.2007.02.031",{"id":28,"text":2968,"url":28,"identifiers":2969},"Powers, 1994, Regional training-induced alterations in diaphragmatic oxidative and antioxidant enzymes, Respir. Physiol., 95, 227, 10.1016\u002F0034-5687(94)90118-X",{"doi":2970},"10.1016\u002F0034-5687(94)90118-X",{"id":28,"text":2972,"url":28,"identifiers":2973},"Gore, 1998, Endurance training alters antioxidant enzyme gene expression in rat skeletal muscle, Can. J. Physiol. Pharmacol., 76, 1139, 10.1139\u002Fy98-125",{"doi":2974},"10.1139\u002Fy98-125",{"id":28,"text":2976,"url":28,"identifiers":2977},"Hollander, 1999, Superoxide dismutase gene expression in skeletal muscle: Fiber-specific adaptation to endurance training, Am. J. Physiol., 277, R856",{},{"id":28,"text":2979,"url":28,"identifiers":2980},"Lambertucci, 2007, Effects of aerobic exercise training on antioxidant enzyme activities and mRNA levels in soleus muscle from young and aged rats, Mech. Ageing Dev., 128, 267, 10.1016\u002Fj.mad.2006.12.006",{"doi":2981},"10.1016\u002Fj.mad.2006.12.006",{"id":28,"text":2983,"url":28,"identifiers":2984},"Ristow, 2009, Antioxidants prevent health-promoting effects of physical exercise in humans, Proc. Natl. Acad. Sci. USA, 106, 8665, 10.1073\u002Fpnas.0903485106",{"doi":2985},"10.1073\u002Fpnas.0903485106",{"id":28,"text":2987,"url":28,"identifiers":2988},"Ji, 1992, Responses of glutathione system and antioxidant enzymes to exhaustive exercise and hydroperoxide, J. Appl. Physiol., 72, 549, 10.1152\u002Fjappl.1992.72.2.549",{"doi":2989},"10.1152\u002Fjappl.1992.72.2.549",{"id":28,"text":2991,"url":28,"identifiers":2992},"Lawler, 1993, Acute exercise and skeletal muscle antioxidant and metabolic enzymes: Effects of fiber type and age, Am. J. Physiol., 265, R1344",{},{"id":28,"text":2994,"url":28,"identifiers":2995},"Hollander, 2001, Superoxide dismutase gene expression is activated by a single bout of exercise in rat skeletal muscle, Pflugers Arch., 442, 426, 10.1007\u002Fs004240100539",{"doi":2996},"10.1007\u002Fs004240100539",{"id":28,"text":2998,"url":28,"identifiers":2999},"Hitomi, 2008, Acute exercise increases expression of extracellular superoxide dismutase in skeletal muscle and the aorta, Redox. Rep., 13, 213, 10.1179\u002F135100008X308894",{"doi":3000},"10.1179\u002F135100008X308894",{"id":28,"text":3002,"url":28,"identifiers":3003},"Asano, 1995, Superoxide dismutase derivative reduces oxidative damage in skeletal muscle of rats during exhaustive exercise, J. Appl. Physiol., 79, 129, 10.1152\u002Fjappl.1995.79.1.129",{"doi":3004},"10.1152\u002Fjappl.1995.79.1.129",{"id":28,"text":3006,"url":28,"identifiers":3007},"Alessio, 1988, Lipid peroxidation and scavenger enzymes during exercise: Adaptive response to training, J. Appl. Physiol., 64, 1333, 10.1152\u002Fjappl.1988.64.4.1333",{"doi":3008},"10.1152\u002Fjappl.1988.64.4.1333",{"id":28,"text":3010,"url":28,"identifiers":3011},"Mastaloudis, 2001, Oxidative stress in athletes during extreme endurance exercise, Free Radic. Biol. Med., 31, 911, 10.1016\u002FS0891-5849(01)00667-0",{"doi":3012},"10.1016\u002FS0891-5849(01)00667-0",{"id":28,"text":3014,"url":28,"identifiers":3015},"Steensberg, 2002, Prolonged exercise, lymphocyte apoptosis and F2-isoprostanes, Eur. J. Appl. Physiol., 87, 38, 10.1007\u002Fs00421-002-0584-6",{"doi":3016},"10.1007\u002Fs00421-002-0584-6",{"id":28,"text":3018,"url":28,"identifiers":3019},"Ashton, 1998, Electron spin resonance spectroscopic detection of oxygen-centred radicals in human serum following exhaustive exercise, Eur. J. Appl. Physiol. Occup. Physiol., 77, 498, 10.1007\u002Fs004210050366",{"doi":3020},"10.1007\u002Fs004210050366",{"id":28,"text":3022,"url":28,"identifiers":3023},"Vasankari, 1995, Measurement of serum lipid peroxidation during exercise using three different methods: Diene conjugation, thiobarbituric acid reactive material and fluorescent chromolipids, Clin. Chim. Acta, 234, 63, 10.1016\u002F0009-8981(94)05976-Y",{"doi":3024},"10.1016\u002F0009-8981(94)05976-Y",{"id":28,"text":3026,"url":28,"identifiers":3027},"Umegaki, 2000, Influence of one bout of vigorous exercise on ascorbic acid in plasma and oxidative damage to DNA in blood cells and muscle in untrained rats, J. Nutr. Biochem., 11, 401, 10.1016\u002FS0955-2863(00)00096-6",{"doi":3028},"10.1016\u002FS0955-2863(00)00096-6",{"id":28,"text":3030,"url":28,"identifiers":3031},"Niess, 1996, DNA damage after exhaustive treadmill running in trained and untrained men, Int. J. Sports Med., 17, 397, 10.1055\u002Fs-2007-972868",{"doi":3032},"10.1055\u002Fs-2007-972868",{"id":28,"text":3034,"url":28,"identifiers":3035},"Powers, 1994, Influence of exercise and fiber type on antioxidant enzyme activity in rat skeletal muscle, Am. J. Physiol., 266, R375",{},{"id":28,"text":3037,"url":28,"identifiers":3038},"Naito, 2002, Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle, Pflugers Arch., 445, 273, 10.1007\u002Fs00424-002-0918-6",{"doi":3039},"10.1007\u002Fs00424-002-0918-6",{"id":28,"text":3041,"url":28,"identifiers":3042},"Chung, 2008, Systemic adaptation to oxidative challenge induced by regular exercise, Free Radic. Biol. Med., 44, 153, 10.1016\u002Fj.freeradbiomed.2007.01.029",{"doi":3043},"10.1016\u002Fj.freeradbiomed.2007.01.029",{"id":28,"text":3045,"url":28,"identifiers":3046},"Alleman, R.J., Katunga, L.A., Nelson, M.A.M., Brown, D.A., and Anderson, E.J. (2014). The “Goldilocks Zone” from a redox perspective—Adaptive vs. deleterious responses to oxidative stress in striated muscle. Front. Physiol.",{"doi":3047},"10.3389\u002Ffphys.2014.00358",{"id":28,"text":3049,"url":28,"identifiers":3050},"Kalogeris, 2014, Mitochondrial reactive oxygen species: A double edged sword in ischemia\u002Freperfusion vs. preconditioning, Redox Biol., 2, 702, 10.1016\u002Fj.redox.2014.05.006",{"doi":3051},"10.1016\u002Fj.redox.2014.05.006",{"id":28,"text":3053,"url":28,"identifiers":3054},"Dodd, 2010, Ros-mediated activation of NF-kappaB and Foxo during muscle disuse, Muscle Nerve, 41, 110, 10.1002\u002Fmus.21526",{"doi":3055},"10.1002\u002Fmus.21526",{"id":28,"text":3057,"url":28,"identifiers":3058},"Derbre, 2012, Inhibition of xanthine oxidase by allopurinol prevents skeletal muscle atrophy: Role of p38 MAPKinase and E3 ubiquitin ligases, PLoS ONE, 7, e46668, 10.1371\u002Fjournal.pone.0046668",{"doi":3059},"10.1371\u002Fjournal.pone.0046668",{"id":28,"text":3061,"url":28,"identifiers":3062},"Jansen, 2012, α1AMP-activated protein kinase mediates vascular protective effects of exercise, Arterioscler. Thromb. Vasc. Biol., 32, 1632, 10.1161\u002FATVBAHA.111.243980",{"doi":3063},"10.1161\u002FATVBAHA.111.243980",{"id":28,"text":3065,"url":28,"identifiers":3066},"Morgan, 2011, Crosstalk of reactive oxygen species and NF-κB signaling, Cell Res., 21, 103, 10.1038\u002Fcr.2010.178",{"doi":3067},"10.1038\u002Fcr.2010.178",{"id":28,"text":3069,"url":28,"identifiers":3070},"McArdle, 2004, Preconditioning of skeletal muscle against contraction-induced damage: The role of adaptations to oxidants in mice, J. Physiol., 561, 233, 10.1113\u002Fjphysiol.2004.069914",{"doi":3071},"10.1113\u002Fjphysiol.2004.069914",{"id":28,"text":3073,"url":28,"identifiers":3074},"Eckl, 1993, Genotoxic properties of 4-hydroxyalkenals and analogous aldehydes, Mutat. Res., 290, 183, 10.1016\u002F0027-5107(93)90158-C",{"doi":3075},"10.1016\u002F0027-5107(93)90158-C",{"id":28,"text":3077,"url":28,"identifiers":3078},"Poli, 2008, 4-hydroxynonenal: A membrane lipid oxidation product of medicinal interest, Med. Res. Rev., 28, 569, 10.1002\u002Fmed.20117",{"doi":3079},"10.1002\u002Fmed.20117",{"id":28,"text":3081,"url":28,"identifiers":3082},"Ishii, 2004, Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: Activation by oxidatively modified LDL and 4-hydroxynonenal, Circ. Res., 94, 609, 10.1161\u002F01.RES.0000119171.44657.45",{"doi":3083},"10.1161\u002F01.RES.0000119171.44657.45",{"id":28,"text":3085,"url":28,"identifiers":3086},"Levonen, 2004, Cellular mechanisms of redox cell signalling: Role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products, Biochem. J., 378, 373, 10.1042\u002Fbj20031049",{"doi":3087},"10.1042\u002Fbj20031049",{"id":28,"text":3089,"url":28,"identifiers":3090},"Echtay, 2003, A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling, EMBO J., 22, 4103, 10.1093\u002Femboj\u002Fcdg412",{"doi":3091},"10.1093\u002Femboj\u002Fcdg412",{"id":28,"text":3093,"url":28,"identifiers":3094},"Sastre, 2005, Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats, J. Physiol., 567, 113, 10.1113\u002Fjphysiol.2004.080564",{"doi":3095},"10.1113\u002Fjphysiol.2004.080564",{"id":28,"text":3097,"url":28,"identifiers":3098},"Domenech, 2008, Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training, Free Radic. Biol. Med., 44, 126, 10.1016\u002Fj.freeradbiomed.2007.02.001",{"doi":3099},"10.1016\u002Fj.freeradbiomed.2007.02.001",{"id":28,"text":3101,"url":28,"identifiers":3102},"Ji, 2004, Acute exercise activates nuclear factor (NF)-kappaB signaling pathway in rat skeletal muscle, FASEB J., 18, 1499, 10.1096\u002Ffj.04-1846com",{"doi":3103},"10.1096\u002Ffj.04-1846com",{"id":28,"text":3105,"url":28,"identifiers":3106},"Margonis, 2007, Oxidative stress biomarkers responses to physical overtraining: Implications for diagnosis, Free Radic. Biol. Med., 43, 901, 10.1016\u002Fj.freeradbiomed.2007.05.022",{"doi":3107},"10.1016\u002Fj.freeradbiomed.2007.05.022",{"id":28,"text":3109,"url":28,"identifiers":3110},"Palazzetti, 2003, Overloaded training increases exercise-induced oxidative stress and damage, Can. J. Appl. Physiol., 28, 588, 10.1139\u002Fh03-045",{"doi":3111},"10.1139\u002Fh03-045",{"id":28,"text":3113,"url":28,"identifiers":3114},"Tanskanen, 2010, Altered oxidative stress in overtrained athletes, J. Sports Sci., 28, 309, 10.1080\u002F02640410903473844",{"doi":3115},"10.1080\u002F02640410903473844",{"id":28,"text":3117,"url":28,"identifiers":3118},"Irrcher, 2003, PPARγ coactivator-1α expression during thyroid hormone- and contractile activity-induced mitochondrial adaptations, Am. J. Physiol. Cell Physiol., 284, C1669, 10.1152\u002Fajpcell.00409.2002",{"doi":3119},"10.1152\u002Fajpcell.00409.2002",{"id":28,"text":3121,"url":28,"identifiers":3122},"Holloszy, 2008, Regulation by exercise of skeletal muscle content of mitochondria and GLUT4, J. Physiol. Pharmacol., 59, 5",{},{"id":28,"text":3124,"url":28,"identifiers":3125},"Yan, 2011, Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle, J. Appl. Physiol., 110, 264, 10.1152\u002Fjapplphysiol.00993.2010",{"doi":3126},"10.1152\u002Fjapplphysiol.00993.2010",{"id":28,"text":3128,"url":28,"identifiers":3129},"Goodpaster, 2006, Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state, Pflugers Arch., 451, 606, 10.1007\u002Fs00424-005-1509-0",{"doi":3130},"10.1007\u002Fs00424-005-1509-0",{"id":28,"text":3132,"url":28,"identifiers":3133},"Hawley, 2008, Exercise training-induced improvements in insulin action, Acta Physiol., 192, 127, 10.1111\u002Fj.1748-1716.2007.01783.x",{"doi":3134},"10.1111\u002Fj.1748-1716.2007.01783.x",{"id":28,"text":3136,"url":28,"identifiers":3137},"Olesen, 2010, PGC-1α-mediated adaptations in skeletal muscle, Pflugers Arch., 460, 153, 10.1007\u002Fs00424-010-0834-0",{"doi":3138},"10.1007\u002Fs00424-010-0834-0",{"id":28,"text":3140,"url":28,"identifiers":3141},"Kang, 2013, Role of PGC-1α in muscle function and aging, J. Sport Health Sci., 2, 81, 10.1016\u002Fj.jshs.2013.03.005",{"doi":3142},"10.1016\u002Fj.jshs.2013.03.005",{"id":28,"text":3144,"url":28,"identifiers":3145},"Pilegaard, 2005, Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise, Metabolism, 54, 1048, 10.1016\u002Fj.metabol.2005.03.008",{"doi":3146},"10.1016\u002Fj.metabol.2005.03.008",{"id":28,"text":3148,"url":28,"identifiers":3149},"Ahlsen, 2006, Human skeletal muscle fibre type variations correlate with PPARα, PPARδ and PGC-1α mRNA, Acta Physiol., 188, 207, 10.1111\u002Fj.1748-1716.2006.01620.x",{"doi":3150},"10.1111\u002Fj.1748-1716.2006.01620.x",{"id":28,"text":3152,"url":28,"identifiers":3153},"Mathai, 2008, Rapid exercise-induced changes in PGC-1α mRNA and protein in human skeletal muscle, J. Appl. Physiol., 105, 1098, 10.1152\u002Fjapplphysiol.00847.2007",{"doi":3154},"10.1152\u002Fjapplphysiol.00847.2007",{"id":28,"text":3156,"url":28,"identifiers":3157},"Little, 2011, An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle, Am. J. Physiol. Regul. Integr. Comp. Physiol., 300, R1303, 10.1152\u002Fajpregu.00538.2010",{"doi":3158},"10.1152\u002Fajpregu.00538.2010",{"id":28,"text":3160,"url":28,"identifiers":3161},"Cobley, 2012, PGC-1α transcriptional response and mitochondrial adaptation to acute exercise is maintained in skeletal muscle of sedentary elderly males, Biogerontology, 13, 621, 10.1007\u002Fs10522-012-9408-1",{"doi":3162},"10.1007\u002Fs10522-012-9408-1",{"id":28,"text":3164,"url":28,"identifiers":3165},"Wright, 2007, Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1α expression, J. Biol. Chem., 282, 194, 10.1074\u002Fjbc.M606116200",{"doi":3166},"10.1074\u002Fjbc.M606116200",{"id":28,"text":3168,"url":28,"identifiers":3169},"Wu, 1999, Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1, Cell, 98, 115, 10.1016\u002FS0092-8674(00)80611-X",{"doi":3170},"10.1016\u002FS0092-8674(00)80611-X",{"id":28,"text":3172,"url":28,"identifiers":3173},"Koves, 2005, Peroxisome proliferator-activated receptor-γ co-activator 1α-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency, J. Biol. Chem., 280, 33588, 10.1074\u002Fjbc.M507621200",{"doi":3174},"10.1074\u002Fjbc.M507621200",{"id":28,"text":3176,"url":28,"identifiers":3177},"Lin, 2002, Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres, Nature, 418, 797, 10.1038\u002Fnature00904",{"doi":3178},"10.1038\u002Fnature00904",{"id":28,"text":3180,"url":28,"identifiers":3181},"Handschin, 2007, Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals, J. Biol. Chem., 282, 30014, 10.1074\u002Fjbc.M704817200",{"doi":3182},"10.1074\u002Fjbc.M704817200",{"id":28,"text":3184,"url":28,"identifiers":3185},"Puigserver, 2003, Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α): Transcriptional coactivator and metabolic regulator, Endocr. Rev., 24, 78, 10.1210\u002Fer.2002-0012",{"doi":3186},"10.1210\u002Fer.2002-0012",{"id":28,"text":3188,"url":28,"identifiers":3189},"Scarpulla, 2012, Transcriptional integration of mitochondrial biogenesis, Trends Endocrinol. Metab., 23, 459, 10.1016\u002Fj.tem.2012.06.006",{"doi":3190},"10.1016\u002Fj.tem.2012.06.006",{"id":28,"text":3192,"url":28,"identifiers":3193},"Oberkofler, 2003, Potentiation of liver X receptor transcriptional activity by peroxisome-proliferator-activated receptor γ co-activator 1α, Biochem. J., 371, 89, 10.1042\u002Fbj20021665",{"doi":3194},"10.1042\u002Fbj20021665",{"id":28,"text":3196,"url":28,"identifiers":3197},"Summermatter, 2010, Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway, J. Biol. Chem., 285, 32793, 10.1074\u002Fjbc.M110.145995",{"doi":3198},"10.1074\u002Fjbc.M110.145995",{"id":28,"text":3200,"url":28,"identifiers":3201},"Arany, 2008, HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α, Nature, 451, 1008, 10.1038\u002Fnature06613",{"doi":3202},"10.1038\u002Fnature06613",{"id":28,"text":3204,"url":28,"identifiers":3205},"Chinsomboon, 2009, The transcriptional coactivator PGC-1α mediates exercise-induced angiogenesis in skeletal muscle, Proc. Natl. Acad. Sci. USA, 106, 21401, 10.1073\u002Fpnas.0909131106",{"doi":3206},"10.1073\u002Fpnas.0909131106",{"id":28,"text":3208,"url":28,"identifiers":3209},"Chin, 1998, A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type, Genes Dev., 12, 2499, 10.1101\u002Fgad.12.16.2499",{"doi":3210},"10.1101\u002Fgad.12.16.2499",{"id":28,"text":3212,"url":28,"identifiers":3213},"Wu, 2000, MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type, EMBO J., 19, 1963, 10.1093\u002Femboj\u002F19.9.1963",{"doi":3214},"10.1093\u002Femboj\u002F19.9.1963",{"id":28,"text":3216,"url":28,"identifiers":3217},"Potthoff, 2007, Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers, J. Clin. Investig., 117, 2459, 10.1172\u002FJCI31960",{"doi":3218},"10.1172\u002FJCI31960",{"id":28,"text":3220,"url":28,"identifiers":3221},"Handschin, 2003, An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle, Proc. Natl. Acad. Sci. USA, 100, 7111, 10.1073\u002Fpnas.1232352100",{"doi":3222},"10.1073\u002Fpnas.1232352100",{"id":28,"text":3224,"url":28,"identifiers":3225},"Kang, 2009, Exercise activation of muscle peroxisome proliferator-activated receptor-gamma coactivator-1α signaling is redox sensitive, Free Radic. Biol. Med., 47, 1394, 10.1016\u002Fj.freeradbiomed.2009.08.007",{"doi":3226},"10.1016\u002Fj.freeradbiomed.2009.08.007",{"id":28,"text":3228,"url":28,"identifiers":3229},"Strobel, 2014, Altering the redox state of skeletal muscle by glutathione depletion increases the exercise-activation of PGC-1α, Physiol. Rep., 2, e12224, 10.14814\u002Fphy2.12224",{"doi":3230},"10.14814\u002Fphy2.12224",{"id":28,"text":3232,"url":28,"identifiers":3233},"Drori, 2006, Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators, Cell, 127, 397, 10.1016\u002Fj.cell.2006.09.024",{"doi":3234},"10.1016\u002Fj.cell.2006.09.024",{"id":28,"text":3236,"url":28,"identifiers":3237},"Kong, 2010, Sirtuin 3, a new target of PGC-1α, plays an important role in the suppression of ROS and mitochondrial biogenesis, PLoS ONE, 5, e11707, 10.1371\u002Fjournal.pone.0011707",{"doi":3238},"10.1371\u002Fjournal.pone.0011707",{"id":28,"text":3240,"url":28,"identifiers":3241},"Ahn, 2008, A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis, Proc. Natl. Acad. Sci. USA, 105, 14447, 10.1073\u002Fpnas.0803790105",{"doi":3242},"10.1073\u002Fpnas.0803790105",{"id":28,"text":3244,"url":28,"identifiers":3245},"Finley, 2011, Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity, PLoS ONE, 6, e23295, 10.1371\u002Fjournal.pone.0023295",{"doi":3246},"10.1371\u002Fjournal.pone.0023295",{"id":28,"text":3248,"url":28,"identifiers":3249},"Qiu, 2010, Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation, Cell Metab., 12, 662, 10.1016\u002Fj.cmet.2010.11.015",{"doi":3250},"10.1016\u002Fj.cmet.2010.11.015",{"id":28,"text":3252,"url":28,"identifiers":3253},"Tao, 2010, Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress, Mol. Cell, 40, 893, 10.1016\u002Fj.molcel.2010.12.013",{"doi":3254},"10.1016\u002Fj.molcel.2010.12.013",{"id":28,"text":3256,"url":28,"identifiers":3257},"Chen, 2011, Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS, EMBO Rep., 12, 534, 10.1038\u002Fembor.2011.65",{"doi":3258},"10.1038\u002Fembor.2011.65",{"id":28,"text":3260,"url":28,"identifiers":3261},"Wenz, 2009, Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging, Proc. Natl. Acad. Sci. USA, 106, 20405, 10.1073\u002Fpnas.0911570106",{"doi":3262},"10.1073\u002Fpnas.0911570106",{"id":28,"text":3264,"url":28,"identifiers":3265},"Lin, 2003, Bioenergetic analysis of peroxisome proliferator-activated receptor γ coactivators 1α and 1β (PGC-1α and PGC-1β) in muscle cells, J. Biol. Chem., 278, 26597, 10.1074\u002Fjbc.M301850200",{"doi":3266},"10.1074\u002Fjbc.M301850200",{"id":3268,"createTime":3269,"updateTime":3269,"relativeEntities":3270,"slug":3271,"properties":3272,"entityType":972,"verifyStatus":26,"verifyTime":3269,"verifyNote":973,"languages":3287,"translateLanguages":28,"viewCount":32,"primaryUrl":3288,"fullTextUrl":28,"authors":3289,"publicationType":1209,"publisherRelationship":3338,"citationCount":3391,"citationInfo":3392,"publishDate":28,"publishYear":28,"citationAnalyzeStatus":881,"lastCitationAnalyze":28,"indexDatabases":3394,"openAccess":28,"references":3395,"isForceReanalyzing":2008},"45689290-268f-4896-959c-2b8634083b96","2025-01-29T03:35:37.931+00:00",[],"Antidiabetic-Properties-of-Naringenin-A-Citrus-Fruit-Polyphenol",{"mag":3273,"pmc":3275,"openalex":3277,"abstract":3279,"title":3281,"pm":3283,"doi":3285},{"VOID":3274},"2921207180",{"VOID":3276},"6468535",{"VOID":3278},"W2921207180",{"EN":3280},"\u003Cjats:p>Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by insulin resistance and hyperglycemia and is associated with personal health and global economic burdens. Current strategies\u002Fapproaches of insulin resistance and T2DM prevention and treatment are lacking in efficacy resulting in the need for new preventative and targeted therapies. In recent years, epidemiological studies have suggested that diets rich in vegetables and fruits are associated with health benefits including protection against insulin resistance and T2DM. Naringenin, a citrus flavanone, has been reported to have antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, immunomodulatory and antidiabetic properties. The current review summarizes the existing in vitro and in vivo animal studies examining the anti-diabetic effects of naringenin.\u003C\u002Fjats:p>",{"EN":3282},"Antidiabetic Properties of Naringenin: A Citrus Fruit Polyphenol",{"VOID":3284},"30871083",{"VOID":3286},"10.3390\u002Fbiom9030099",[31],"https:\u002F\u002Fwww.mdpi.com\u002F2218-273X\u002F9\u002F3\u002F99",[3290,3315],{"id":3291,"sortIndex":32,"researcher":28,"roles":3292,"affiliations":3293,"properties":3310,"displayName":3312,"givenName":28,"familyName":28},"1d119bac-dde6-43f5-b753-a5b1863e338b",[],[3294,3302],{"id":3295,"sortIndex":32,"affiliation":3296,"properties":28},"0184ab42-d458-45e6-9e6e-b3c56149ee07",{"id":3295,"createTime":28,"updateTime":28,"relativeEntities":3297,"slug":28,"properties":3298,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3301,"statistic":28},[],{"title":3299},{"VI":3300},"Centre for Bone and Muscle Health, Brock University, St. Catharines, ON L2S 3A1, Canada",[],{"id":3303,"sortIndex":40,"affiliation":3304,"properties":28},"d91a5505-4965-4df8-85fa-88283f236331",{"id":3303,"createTime":28,"updateTime":28,"relativeEntities":3305,"slug":28,"properties":3306,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3309,"statistic":28},[],{"title":3307},{"VI":3308},"Department of Health Sciences, Brock University, St. Catharines, ON, L2S 3A1, Canada",[],{"title":3311,"openalex":3313},{"EN":3312},"Danja J. 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Diab. Rep., 10, 184, 10.1007\u002Fs11892-010-0115-5",{"doi":3403},"10.1007\u002Fs11892-010-0115-5",{"id":28,"text":3405,"url":28,"identifiers":3406},"Petersen, 2018, Mechanisms of Insulin Action and Insulin Resistance, Physiol. Rev., 98, 2133, 10.1152\u002Fphysrev.00063.2017",{"doi":3407},"10.1152\u002Fphysrev.00063.2017",{"id":28,"text":3409,"url":28,"identifiers":3410},"Saltiel, 2001, New perspectives into the molecular pathogenesis and treatment of type 2 diabetes, Cell, 104, 517, 10.1016\u002FS0092-8674(01)00239-2",{"doi":3411},"10.1016\u002FS0092-8674(01)00239-2",{"id":28,"text":3413,"url":28,"identifiers":3414},"Alam, 2014, Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action, Adv. Nutr., 5, 404, 10.3945\u002Fan.113.005603",{"doi":3415},"10.3945\u002Fan.113.005603",{"id":28,"text":3417,"url":28,"identifiers":3418},"DeFronzo, 2004, Dysfunctional fat cells, lipotoxicity and type 2 diabetes, Int. J. Clin. Pract. Suppl., 58, 9, 10.1111\u002Fj.1368-504X.2004.00389.x",{"doi":3419},"10.1111\u002Fj.1368-504X.2004.00389.x",{"id":28,"text":3421,"url":28,"identifiers":3422},"Lee, 2006, PPAR regulates glucose metabolism and insulin sensitivity, Proc. Natl. Acad. Sci. USA, 103, 3444, 10.1073\u002Fpnas.0511253103",{"doi":3423},"10.1073\u002Fpnas.0511253103",{"id":28,"text":3425,"url":28,"identifiers":3426},"Defronzo, 2009, Banting Lecture. From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus, Diabetes, 58, 773, 10.2337\u002Fdb09-9028",{"doi":3427},"10.2337\u002Fdb09-9028",{"id":28,"text":3429,"url":28,"identifiers":3430},"Frigolet, 2013, The renin-angiotensin system in adipose tissue and its metabolic consequences during obesity, J. Nutr. Biochem., 24, 2003, 10.1016\u002Fj.jnutbio.2013.07.002",{"doi":3431},"10.1016\u002Fj.jnutbio.2013.07.002",{"id":28,"text":3433,"url":28,"identifiers":3434},"Hotamisligil, 1994, Tumor necrosis factor alpha: A key component of the obesity-diabetes link, Diabetes, 43, 1271, 10.2337\u002Fdiab.43.11.1271",{"doi":3435},"10.2337\u002Fdiab.43.11.1271",{"id":28,"text":3437,"url":28,"identifiers":3438},"Cho, 2018, IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045, Diabetes Res. Clin. Pract., 138, 271, 10.1016\u002Fj.diabres.2018.02.023",{"doi":3439},"10.1016\u002Fj.diabres.2018.02.023",{"id":28,"text":3441,"url":28,"identifiers":3442},"Shrestha, 2019, Factors Contributing to Increases in Diabetes-Related Preventable Hospitalization Costs Among U.S. Adults During 2001–2014, Diabetes Care, 42, 77, 10.2337\u002Fdc18-1078",{"doi":3443},"10.2337\u002Fdc18-1078",{"id":28,"text":3445,"url":28,"identifiers":3446},"Baur, 2006, Therapeutic potential of resveratrol: The in vivo evidence, Nat. Rev. Drug. Discov., 5, 493, 10.1038\u002Fnrd2060",{"doi":3447},"10.1038\u002Fnrd2060",{"id":28,"text":3449,"url":28,"identifiers":3450},"Park, 2015, The pharmacology of resveratrol in animals and humans, Biochim. Biophys. Acta, 1852, 1071, 10.1016\u002Fj.bbadis.2015.01.014",{"doi":3451},"10.1016\u002Fj.bbadis.2015.01.014",{"id":28,"text":3453,"url":28,"identifiers":3454},"Anja, 2017, The cost of diabetes in Canada over 10 years: Applying attributable health care costs to a diabetes incidence prediction model, Health Promot. Chronic Dis. Prev. Can., 37, 49, 10.24095\u002Fhpcdp.37.2.03",{"doi":3455},"10.24095\u002Fhpcdp.37.2.03",{"id":28,"text":3457,"url":28,"identifiers":3458},"Vieira, 2016, Fruits, vegetables and lung cancer risk: A systematic review and meta-analysis, Ann. Oncol., 27, 81, 10.1093\u002Fannonc\u002Fmdv381",{"doi":3459},"10.1093\u002Fannonc\u002Fmdv381",{"id":28,"text":3461,"url":28,"identifiers":3462},"Kuzma, 2017, Prevention of metabolic diseases: Fruits (including fruit sugars) vs. vegetables, Curr. Opin. Clin. Nutr. Metab. Care, 20, 286, 10.1097\u002FMCO.0000000000000378",{"doi":3463},"10.1097\u002FMCO.0000000000000378",{"id":28,"text":3465,"url":28,"identifiers":3466},"Stefan, 2018, Metabolically healthy obesity: The low-hanging fruit in obesity treatment?, Lancet Diabetes Endocrinol., 6, 249, 10.1016\u002FS2213-8587(17)30292-9",{"doi":3467},"10.1016\u002FS2213-8587(17)30292-9",{"id":28,"text":3469,"url":28,"identifiers":3470},"Serino, A., and Salazar, G. (2018). Protective Role of Polyphenols against Vascular Inflammation, Aging and Cardiovascular Disease. Nutrients, 11.",{"doi":3471},"10.3390\u002Fnu11010053",{"id":28,"text":3473,"url":28,"identifiers":3474},"Moore, J., Yousef, M., and Tsiani, E. (2016). Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols. Nutrients, 8.",{"doi":3475},"10.3390\u002Fnu8110731",{"id":28,"text":3477,"url":28,"identifiers":3478},"Yousef, M., Vlachogiannis, I.A., and Tsiani, E. (2017). Effects of Resveratrol against Lung Cancer: In Vitro and In Vivo Studies. Nutrients, 9.",{"doi":3479},"10.3390\u002Fnu9111231",{"id":28,"text":3481,"url":28,"identifiers":3482},"Naimi, M., Vlavcheski, F., Shamshoum, H., and Tsiani, E. (2017). Rosemary Extract as a Potential Anti-Hyperglycemic Agent: Current Evidence and Future Perspectives. Nutrients, 9.",{"doi":3483},"10.3390\u002Fnu9090968",{"id":28,"text":3485,"url":28,"identifiers":3486},"Dreosti, 2000, Antioxidant polyphenols in tea, cocoa, and wine, Nutrition, 16, 692, 10.1016\u002FS0899-9007(00)00304-X",{"doi":3487},"10.1016\u002FS0899-9007(00)00304-X",{"id":28,"text":3489,"url":28,"identifiers":3490},"Lagouge, 2006, Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha, Cell, 127, 1109, 10.1016\u002Fj.cell.2006.11.013",{"doi":3491},"10.1016\u002Fj.cell.2006.11.013",{"id":28,"text":3493,"url":28,"identifiers":3494},"Amor, S., Châlons, P., Aires, V., and Delmas, D. (2018). Polyphenol Extracts from Red Wine and Grapevine: Potential Effects on Cancers. Diseases, 6.",{"doi":3495},"10.3390\u002Fdiseases6040106",{"id":28,"text":3497,"url":28,"identifiers":3498},"Yahfoufi, N., Alsadi, N., Jambi, M., and Matar, C. (2018). The Immunomodulatory and Anti-Inflammatory Role of Polyphenols. Nutrients, 10.",{"doi":3499},"10.3390\u002Fnu10111618",{"id":28,"text":3501,"url":28,"identifiers":3502},"Filesi, 2007, Polyphenols, dietary sources and bioavailability, Ann. Ist. Super. Sanita, 43, 348",{},{"id":28,"text":3504,"url":28,"identifiers":3505},"Kumar, 2013, Chemistry and Biological Activities of Flavonoids: An Overview, Sci. World J., 2013, 162750, 10.1155\u002F2013\u002F162750",{"doi":3506},"10.1155\u002F2013\u002F162750",{"id":28,"text":3508,"url":28,"identifiers":3509},"Erlund, 2004, Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology, Nutr. Res., 24, 851, 10.1016\u002Fj.nutres.2004.07.005",{"doi":3510},"10.1016\u002Fj.nutres.2004.07.005",{"id":28,"text":3512,"url":28,"identifiers":3513},"Gattuso, 2007, Flavonoid Composition of Citrus Juices, Molecules, 12, 1641, 10.3390\u002F12081641",{"doi":3514},"10.3390\u002F12081641",{"id":28,"text":3516,"url":28,"identifiers":3517},"Aherne, 2002, Dietary flavonols: Chemistry, food content, and metabolism, Nutrition, 18, 75, 10.1016\u002FS0899-9007(01)00695-5",{"doi":3518},"10.1016\u002FS0899-9007(01)00695-5",{"id":28,"text":3520,"url":28,"identifiers":3521},"Zaidun, 2018, Combating oxidative stress disorders with citrus flavonoid: Naringenin, Life Sci., 208, 111, 10.1016\u002Fj.lfs.2018.07.017",{"doi":3522},"10.1016\u002Fj.lfs.2018.07.017",{"id":28,"text":3524,"url":28,"identifiers":3525},"Sharma, 2015, Emerging potential of citrus flavanones as an antioxidant in diabetes and its complications, Curr. Top. Med. Chem., 15, 187, 10.2174\u002F1568026615666141209163013",{"doi":3526},"10.2174\u002F1568026615666141209163013",{"id":28,"text":3528,"url":28,"identifiers":3529},"Coelho, 2013, Anti-inflammatory properties of orange juice: Possible favorable molecular and metabolic effects, Plant. Foods Hum. Nutr., 68, 1, 10.1007\u002Fs11130-013-0343-3",{"doi":3530},"10.1007\u002Fs11130-013-0343-3",{"id":28,"text":3532,"url":28,"identifiers":3533},"Rani, 2016, Pharmacological Properties and Therapeutic Potential of Naringenin: A Citrus Flavonoid of Pharmaceutical Promise, Curr. Pharm. Des., 22, 4341, 10.2174\u002F1381612822666160530150936",{"doi":3534},"10.2174\u002F1381612822666160530150936",{"id":28,"text":3536,"url":28,"identifiers":3537},"Zeng, 2018, Naringenin as a potential immunomodulator in therapeutics, Pharmacol. Res., 135, 122, 10.1016\u002Fj.phrs.2018.08.002",{"doi":3538},"10.1016\u002Fj.phrs.2018.08.002",{"id":28,"text":3540,"url":28,"identifiers":3541},"Muriel, 2018, Beneficial effects of naringenin in liver diseases: Molecular mechanisms, World J. Gastroenterol., 24, 1679, 10.3748\u002Fwjg.v24.i16.1679",{"doi":3542},"10.3748\u002Fwjg.v24.i16.1679",{"id":28,"text":3544,"url":28,"identifiers":3545},"Mulvihill, 2010, Naringenin decreases progression of atherosclerosis by improving dyslipidemia in high-fat-fed low-density lipoprotein receptor-null mice, Arterioscler. Thromb. Vasc. Biol., 30, 742, 10.1161\u002FATVBAHA.109.201095",{"doi":3546},"10.1161\u002FATVBAHA.109.201095",{"id":28,"text":3548,"url":28,"identifiers":3549},"Orhan, 2015, Naringenin and atherosclerosis: A review of literature, Curr. Pharm. Biotechnol., 16, 245, 10.2174\u002F1389201015666141202110216",{"doi":3550},"10.2174\u002F1389201015666141202110216",{"id":28,"text":3552,"url":28,"identifiers":3553},"Mulvihill, 2016, Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis, Annu. Rev. Nutr., 36, 275, 10.1146\u002Fannurev-nutr-071715-050718",{"doi":3554},"10.1146\u002Fannurev-nutr-071715-050718",{"id":28,"text":3556,"url":28,"identifiers":3557},"Testai, L., and Calderone, V. (2017). Nutraceutical Value of Citrus Flavanones and Their Implications in Cardiovascular Disease. Nutrients, 9.",{"doi":3558},"10.3390\u002Fnu9050502",{"id":28,"text":3560,"url":28,"identifiers":3561},"Assini, 2013, Citrus flavonoids and lipid metabolism, Curr. Opin. Lipidol., 24, 34, 10.1097\u002FMOL.0b013e32835c07fd",{"doi":3562},"10.1097\u002FMOL.0b013e32835c07fd",{"id":28,"text":3564,"url":28,"identifiers":3565},"Kannappan, 2010, Naringenin enhances insulin-stimulated tyrosine phosphorylation and improves the cellular actions of insulin in a dietary model of metabolic syndrome, Eur. J. Nutr., 49, 101, 10.1007\u002Fs00394-009-0054-6",{"doi":3566},"10.1007\u002Fs00394-009-0054-6",{"id":28,"text":3568,"url":28,"identifiers":3569},"Kanaze, 2007, Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects, Eur. J. Clin. Nutr., 61, 472, 10.1038\u002Fsj.ejcn.1602543",{"doi":3570},"10.1038\u002Fsj.ejcn.1602543",{"id":28,"text":3572,"url":28,"identifiers":3573},"Marks, 2004, The differential tissue distribution of the citrus flavanone naringenin following gastric instillation, Free Radic. Res., 38, 1329, 10.1080\u002F10715760400017293",{"doi":3574},"10.1080\u002F10715760400017293",{"id":28,"text":3576,"url":28,"identifiers":3577},"Zygmunt, 2010, Naringenin, a citrus flavonoid, increases muscle cell glucose uptake via AMPK, Biochem. Biophys. Res. Commun., 398, 178, 10.1016\u002Fj.bbrc.2010.06.048",{"doi":3578},"10.1016\u002Fj.bbrc.2010.06.048",{"id":28,"text":3580,"url":28,"identifiers":3581},"Bhattacharya, 2013, Bioactive components from flowers of Sambucus nigra L. increase glucose uptake in primary porcine myotube cultures and reduce fat accumulation in Caenorhabditis elegans, J. Agric. Food Chem., 61, 11033, 10.1021\u002Fjf402838a",{"doi":3582},"10.1021\u002Fjf402838a",{"id":28,"text":3584,"url":28,"identifiers":3585},"2017, Polyphenols activate energy sensing network in insulin resistant models, Chem. Biol. Interact., 275, 95, 10.1016\u002Fj.cbi.2017.07.016",{"doi":3586},"10.1016\u002Fj.cbi.2017.07.016",{"id":28,"text":3588,"url":28,"identifiers":3589},"Iossa, 2017, Skeletal muscle insulin resistance: Role of mitochondria and other ROS sources, J. Endocrinol., 233, R15, 10.1530\u002FJOE-16-0598",{"doi":3590},"10.1530\u002FJOE-16-0598",{"id":28,"text":3592,"url":28,"identifiers":3593},"Haber, 2003, N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: Possible role of oxidative stress, Am. J. Physiol. Endocrinol. Metab., 285, 744, 10.1152\u002Fajpendo.00355.2002",{"doi":3594},"10.1152\u002Fajpendo.00355.2002",{"id":28,"text":3596,"url":28,"identifiers":3597},"Harmon, 2001, Differential effects of flavonoids on 3T3-L1 adipogenesis and lipolysis, Am. J. Physiol. Cell Physiol., 280, C807, 10.1152\u002Fajpcell.2001.280.4.C807",{"doi":3598},"10.1152\u002Fajpcell.2001.280.4.C807",{"id":28,"text":3600,"url":28,"identifiers":3601},"Yoshida, 2010, The citrus flavonoids hesperetin and naringenin block the lipolytic actions of TNF-alpha in mouse adipocytes, Biochem. Biophys. Res. Commun., 394, 728, 10.1016\u002Fj.bbrc.2010.03.060",{"doi":3602},"10.1016\u002Fj.bbrc.2010.03.060",{"id":28,"text":3604,"url":28,"identifiers":3605},"Claussnitzer, 2011, Effect of flavonoids on basal and insulin-stimulated 2-deoxyglucose uptake in adipocytes, Mol. Nutr. Food Res., 55, S26, 10.1002\u002Fmnfr.201000372",{"doi":3606},"10.1002\u002Fmnfr.201000372",{"id":28,"text":3608,"url":28,"identifiers":3609},"Yoshida, 2013, Citrus flavonoid naringenin inhibits TLR2 expression in adipocytes, J. Nutr. Biochem., 24, 1276, 10.1016\u002Fj.jnutbio.2012.10.003",{"doi":3610},"10.1016\u002Fj.jnutbio.2012.10.003",{"id":28,"text":3612,"url":28,"identifiers":3613},"Richard, 2013, Naringenin inhibits adipogenesis and reduces insulin sensitivity and adiponectin expression in adipocytes, Evid. Based Complement. Altern. Med., 2013, 549750, 10.1155\u002F2013\u002F549750",{"doi":3614},"10.1155\u002F2013\u002F549750",{"id":28,"text":3616,"url":28,"identifiers":3617},"Rebello, 2019, Naringenin Promotes Thermogenic Gene Expression in Human White Adipose Tissue, Obesity, 27, 103, 10.1002\u002Foby.22352",{"doi":3618},"10.1002\u002Foby.22352",{"id":28,"text":3620,"url":28,"identifiers":3621},"Kaisanlahti, 2018, Browning of white fat: Agents and implications for beige adipose tissue to type 2 diabetes, J. Physiol. Biochem., 75, 1, 10.1007\u002Fs13105-018-0658-5",{"doi":3622},"10.1007\u002Fs13105-018-0658-5",{"id":28,"text":3624,"url":28,"identifiers":3625},"Wilcox, 2001, Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP, J. Lipid Res., 42, 725, 10.1016\u002FS0022-2275(20)31634-5",{"doi":3626},"10.1016\u002FS0022-2275(20)31634-5",{"id":28,"text":3628,"url":28,"identifiers":3629},"Borradaile, 2003, Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation, Diabetes, 52, 2554, 10.2337\u002Fdiabetes.52.10.2554",{"doi":3630},"10.2337\u002Fdiabetes.52.10.2554",{"id":28,"text":3632,"url":28,"identifiers":3633},"Allister, 2008, Inhibition of apoB secretion from HepG2 cells by insulin is amplified by naringenin, independent of the insulin receptor, J. Lipid Res., 49, 2218, 10.1194\u002Fjlr.M800297-JLR200",{"doi":3634},"10.1194\u002Fjlr.M800297-JLR200",{"id":28,"text":3636,"url":28,"identifiers":3637},"Purushotham, 2009, The citrus fruit flavonoid naringenin suppresses hepatic glucose production from Fao hepatoma cells, Mol. Nutr. Food Res., 53, 300, 10.1002\u002Fmnfr.200700514",{"doi":3638},"10.1002\u002Fmnfr.200700514",{"id":28,"text":3640,"url":28,"identifiers":3641},"Goldwasser, J., Cohen, P.Y., Yang, E., Balaguer, P., Yarmush, M.L., and Nahmias, Y. (2010). Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: Role of PPARalpha, PPARgamma and LXRalpha. PLoS ONE, 5.",{"doi":3642},"10.1371\u002Fjournal.pone.0012399",{"id":28,"text":3644,"url":28,"identifiers":3645},"Constantin, 2014, Molecular mechanisms of citrus flavanones on hepatic gluconeogenesis, Fitoterapia, 92, 148, 10.1016\u002Fj.fitote.2013.11.003",{"doi":3646},"10.1016\u002Fj.fitote.2013.11.003",{"id":28,"text":3648,"url":28,"identifiers":3649},"Bhattacharya, 2014, Caffeic acid, naringenin and quercetin enhance glucose-stimulated insulin secretion and glucose sensitivity in INS-1E cells, Diabetes Obes. Metab., 16, 602, 10.1111\u002Fdom.12236",{"doi":3650},"10.1111\u002Fdom.12236",{"id":28,"text":3652,"url":28,"identifiers":3653},"Li, 2006, Inhibition of intestinal and renal Na+-glucose cotransporter by naringenin, Int. J. Biochem. Cell Biol., 38, 985, 10.1016\u002Fj.biocel.2005.10.002",{"doi":3654},"10.1016\u002Fj.biocel.2005.10.002",{"id":28,"text":3656,"url":28,"identifiers":3657},"Webster, 2008, Antidiabetic and toxicological evaluations of naringenin in normoglycaemic and NIDDM rat models and its implications on extra-pancreatic glucose regulation, Diabetes Obes. Metab., 10, 1097, 10.1111\u002Fj.1463-1326.2008.00869.x",{"doi":3658},"10.1111\u002Fj.1463-1326.2008.00869.x",{"id":28,"text":3660,"url":28,"identifiers":3661},"Punithavathi, 2008, Combined treatment with naringin and vitamin C ameliorates streptozotocin-induced diabetes in male Wistar rats, J. Appl. Toxicol., 28, 806, 10.1002\u002Fjat.1343",{"doi":3662},"10.1002\u002Fjat.1343",{"id":28,"text":3664,"url":28,"identifiers":3665},"Tsai, 2012, Anti-inflammatory and antifibrotic effects of naringenin in diabetic mice, J. Agric. Food Chem., 60, 514, 10.1021\u002Fjf203259h",{"doi":3666},"10.1021\u002Fjf203259h",{"id":28,"text":3668,"url":28,"identifiers":3669},"Sharma, 2011, Up-regulation of PPARγ, heat shock protein-27 and -72 by naringin attenuates insulin resistance, β-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes, Br. J. Nutr., 106, 1713, 10.1017\u002FS000711451100225X",{"doi":3670},"10.1017\u002FS000711451100225X",{"id":28,"text":3672,"url":28,"identifiers":3673},"Annadurai, 2012, Antihyperglycemic and antioxidant effects of a flavanone, naringenin, in streptozotocin-nicotinamide-induced experimental diabetic rats, J. Physiol. Biochem., 68, 307, 10.1007\u002Fs13105-011-0142-y",{"doi":3674},"10.1007\u002Fs13105-011-0142-y",{"id":28,"text":3676,"url":28,"identifiers":3677},"Mahmoud, 2012, Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed\u002Fstreptozotocin-induced type 2 diabetic rats, J. Diabetes Complicat., 26, 483, 10.1016\u002Fj.jdiacomp.2012.06.001",{"doi":3678},"10.1016\u002Fj.jdiacomp.2012.06.001",{"id":28,"text":3680,"url":28,"identifiers":3681},"Priscilla, 2014, Naringenin inhibits α-glucosidase activity: A promising strategy for the regulation of postprandial hyperglycemia in high fat diet fed streptozotocin induced diabetic rats, Chem. Biol. Interact., 210, 77, 10.1016\u002Fj.cbi.2013.12.014",{"doi":3682},"10.1016\u002Fj.cbi.2013.12.014",{"id":28,"text":3684,"url":28,"identifiers":3685},"Hasanein, 2014, Role of naringenin in protection against diabetic hyperalgesia and tactile allodynia in male Wistar rats, J. Physiol. Biochem., 70, 997, 10.1007\u002Fs13105-014-0369-5",{"doi":3686},"10.1007\u002Fs13105-014-0369-5",{"id":28,"text":3688,"url":28,"identifiers":3689},"Kapoor, 2014, Naringenin accords hepatoprotection from streptozotocin induced diabetes in vivo by modulating mitochondrial dysfunction and apoptotic signaling cascade, Toxicol. Rep., 1, 569, 10.1016\u002Fj.toxrep.2014.08.002",{"doi":3690},"10.1016\u002Fj.toxrep.2014.08.002",{"id":28,"text":3692,"url":28,"identifiers":3693},"Aleisa, 2015, Naringenin neutralises oxidative stress and nerve growth factor discrepancy in experimental diabetic neuropathy, Neurol. Res., 37, 924, 10.1179\u002F1743132815Y.0000000079",{"doi":3694},"10.1179\u002F1743132815Y.0000000079",{"id":28,"text":3696,"url":28,"identifiers":3697},"Ren, 2016, Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats, Eur. J. Pharmacol., 773, 13, 10.1016\u002Fj.ejphar.2016.01.002",{"doi":3698},"10.1016\u002Fj.ejphar.2016.01.002",{"id":28,"text":3700,"url":28,"identifiers":3701},"Yan, 2016, Naringenin Ameliorated Kidney Injury through Let-7a\u002FTGFBR1 Signaling in Diabetic Nephropathy, J. Diabetes Res., 2016, 8738760, 10.1155\u002F2016\u002F8738760",{"doi":3702},"10.1155\u002F2016\u002F8738760",{"id":28,"text":3704,"url":28,"identifiers":3705},"Roy, 2016, Naringenin ameliorates streptozotocin-induced diabetic rat renal impairment by downregulation of TGF-β1 and IL-1 via modulation of oxidative stress correlates with decreased apoptotic events, Pharm. Biol., 54, 1616, 10.3109\u002F13880209.2015.1110599",{"doi":3706},"10.3109\u002F13880209.2015.1110599",{"id":28,"text":3708,"url":28,"identifiers":3709},"Al-Dosari, D.I., Ahmed, M.M., Al-Rejaie, S.S., Alhomida, A.S., and Ola, M.S. (2017). Flavonoid Naringenin Attenuates Oxidative Stress, Apoptosis and Improves Neurotrophic Effects in the Diabetic Rat Retina. Nutrients, 9.",{"doi":3710},"10.3390\u002Fnu9101161",{"id":28,"text":3712,"url":28,"identifiers":3713},"Ahmed, 2017, Navel orange peel hydroethanolic extract, naringin and naringenin have anti-diabetic potentials in type 2 diabetic rats, Biomed. Pharmacother., 94, 197, 10.1016\u002Fj.biopha.2017.07.094",{"doi":3714},"10.1016\u002Fj.biopha.2017.07.094",{"id":28,"text":3716,"url":28,"identifiers":3717},"Singh, 2018, Isolated mangiferin and naringenin exert antidiabetic effect via PPARγ\u002FGLUT4 dual agonistic action with strong metabolic regulation, Chem. Biol. Interact., 280, 33, 10.1016\u002Fj.cbi.2017.12.007",{"doi":3718},"10.1016\u002Fj.cbi.2017.12.007",{"id":28,"text":3720,"url":28,"identifiers":3721},"Gajski, 2011, DNA-protective effects of quercetin or naringenin in alloxan-induced diabetic mice, Eur. J. Pharmacol., 656, 110, 10.1016\u002Fj.ejphar.2011.01.021",{"doi":3722},"10.1016\u002Fj.ejphar.2011.01.021",{"id":28,"text":3724,"url":28,"identifiers":3725},"Sirovina, 2016, Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: A preliminary study, Arh. Hig. Rada Toksikol., 67, 19, 10.1515\u002Faiht-2016-67-2708",{"doi":3726},"10.1515\u002Faiht-2016-67-2708",{"id":28,"text":3728,"url":28,"identifiers":3729},"Jung, 2006, Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice, Int. J. Biochem. Cell Biol., 38, 1134, 10.1016\u002Fj.biocel.2005.12.002",{"doi":3730},"10.1016\u002Fj.biocel.2005.12.002",{"id":28,"text":3732,"url":28,"identifiers":3733},"Burke, A.C., Telford, D.E., Edwards, J.Y., Sutherland, B.G., Sawyez, C.G., and Huff, M.W. (2018). Naringenin Supplementation to a Chow Diet Enhances Energy Expenditure and Fatty Acid Oxidation, and Reduces Adiposity in Lean, Pair-Fed Ldlr−\u002F− Mice. Mol. Nutr. Food Res.",{"doi":3734},"10.1016\u002Fj.atherosclerosissup.2018.04.068",{"id":28,"text":3736,"url":28,"identifiers":3737},"Jeon, 2004, Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits, Clin. Nutr., 23, 1025, 10.1016\u002Fj.clnu.2004.01.006",{"doi":3738},"10.1016\u002Fj.clnu.2004.01.006",{"id":28,"text":3740,"url":28,"identifiers":3741},"Mulvihill, 2009, Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance, Diabetes, 58, 2198, 10.2337\u002Fdb09-0634",{"doi":3742},"10.2337\u002Fdb09-0634",{"id":28,"text":3744,"url":28,"identifiers":3745},"Cho, 2011, Dietary naringenin increases hepatic peroxisome proliferators-activated receptor α protein expression and decreases plasma triglyceride and adiposity in rats, Eur. J. Nutr., 50, 81, 10.1007\u002Fs00394-010-0117-8",{"doi":3746},"10.1007\u002Fs00394-010-0117-8",{"id":28,"text":3748,"url":28,"identifiers":3749},"Pu, 2012, Naringin ameliorates metabolic syndrome by activating AMP-activated protein kinase in mice fed a high-fat diet, Arch. Biochem. Biophys., 518, 61, 10.1016\u002Fj.abb.2011.11.026",{"doi":3750},"10.1016\u002Fj.abb.2011.11.026",{"id":28,"text":3752,"url":28,"identifiers":3753},"Alam, 2013, Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats, Nutrients, 5, 637, 10.3390\u002Fnu5030637",{"doi":3754},"10.3390\u002Fnu5030637",{"id":28,"text":3756,"url":28,"identifiers":3757},"Assini, 2013, Naringenin prevents cholesterol-induced systemic inflammation, metabolic dysregulation, and atherosclerosis in Ldlr−\u002F− mice, J. Lipid Res., 54, 711, 10.1194\u002Fjlr.M032631",{"doi":3758},"10.1194\u002Fjlr.M032631",{"id":28,"text":3760,"url":28,"identifiers":3761},"Yoshida, 2014, Naringenin suppresses macrophage infiltration into adipose tissue in an early phase of high-fat diet-induced obesity, Biochem. Biophys. Res. Commun., 454, 95, 10.1016\u002Fj.bbrc.2014.10.038",{"doi":3762},"10.1016\u002Fj.bbrc.2014.10.038",{"id":28,"text":3764,"url":28,"identifiers":3765},"Assini, 2015, Naringenin prevents obesity, hepatic steatosis, and glucose intolerance in male mice independent of fibroblast growth factor 21, Endocrinology, 156, 2087, 10.1210\u002Fen.2014-2003",{"doi":3766},"10.1210\u002Fen.2014-2003",{"id":28,"text":3768,"url":28,"identifiers":3769},"Chtourou, 2016, Naringenin ameliorates renal and platelet purinergic signalling alterations in high-cholesterol fed rats through the suppression of ROS and NF-κB signaling pathways, Food Funct., 7, 183, 10.1039\u002FC5FO00871A",{"doi":3770},"10.1039\u002FC5FO00871A",{"id":28,"text":3772,"url":28,"identifiers":3773},"Burke, 2018, Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr−\u002F− mice, J. Lipid Res., 59, 1714, 10.1194\u002Fjlr.M087387",{"doi":3774},"10.1194\u002Fjlr.M087387",{"id":28,"text":3776,"url":28,"identifiers":3777},"Knekt, 2002, Flavonoid intake and risk of chronic diseases, Am. J. Clin. Nutr., 76, 560, 10.1093\u002Fajcn\u002F76.3.560",{"doi":3778},"10.1093\u002Fajcn\u002F76.3.560",{"id":28,"text":3780,"url":28,"identifiers":3781},"Farook, 2015, Metabolites as Novel Biomarkers for Childhood Obesity-Related Traits in Mexican American Children, Pediatr. Obes., 10, 320, 10.1111\u002Fijpo.270",{"doi":3782},"10.1111\u002Fijpo.270",{"id":28,"text":3784,"url":28,"identifiers":3785},"Jung, 2003, Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects, Clin. Nutr., 22, 561, 10.1016\u002FS0261-5614(03)00059-1",{"doi":3786},"10.1016\u002FS0261-5614(03)00059-1",{"id":28,"text":3788,"url":28,"identifiers":3789},"Dallas, 2014, Clinical Study to Assess the Efficacy and Safety of a Citrus Polyphenolic Extract of Red Orange, Grapefruit, and Orange (Sinetrol-XPur) on Weight Management and Metabolic Parameters in Healthy Overweight Individuals, Phytother. Res., 28, 212, 10.1002\u002Fptr.4981",{"doi":3790},"10.1002\u002Fptr.4981",{"id":3792,"createTime":3793,"updateTime":3793,"relativeEntities":3794,"slug":3795,"properties":3796,"entityType":972,"verifyStatus":26,"verifyTime":3793,"verifyNote":973,"languages":3811,"translateLanguages":28,"viewCount":32,"primaryUrl":3812,"fullTextUrl":28,"authors":3813,"publicationType":1209,"publisherRelationship":3878,"citationCount":3931,"citationInfo":3932,"publishDate":28,"publishYear":28,"citationAnalyzeStatus":881,"lastCitationAnalyze":28,"indexDatabases":3934,"openAccess":28,"references":3935,"isForceReanalyzing":2008},"8b7eafbb-c117-4155-9f56-70e8c6dc65a7","2025-01-28T19:34:39.134+00:00",[],"MYC-Driven-Pathways-in-Breast-Cancer-Subtypes",{"mag":3797,"pmc":3799,"openalex":3801,"abstract":3803,"title":3805,"pm":3807,"doi":3809},{"VOID":3798},"2734462584",{"VOID":3800},"5618234",{"VOID":3802},"W2734462584",{"EN":3804},"\u003Cjats:p>The transcription factor MYC (MYC proto-oncogene, bHLH transcription factor) is an essential signaling hub in multiple cellular processes that sustain growth of many types of cancers. MYC regulates expression of RNA, both protein and non-coding, that control central metabolic pathways, cell death, proliferation, differentiation, stress pathways, and mechanisms of drug resistance. Activation of MYC has been widely reported in breast cancer progression. Breast cancer is a complex heterogeneous disease and treatment options are primarily guided by histological and biochemical evaluations of the tumors. Based on biochemical markers, three main breast cancer categories are ER+ (estrogen receptor alpha positive), HER2+ (human epidermal growth factor receptor 2 positive), and TNBC (triple-negative breast cancer; estrogen receptor negative, progesterone receptor negative, HER2 negative). MYC is elevated in TNBC compared with other cancer subtypes. Interestingly, MYC-driven pathways are further elevated in aggressive breast cancer cells and tumors that display drug resistant phenotype. Identification of MYC target genes is essential in isolating signaling pathways that drive tumor development. In this review, we address the role of MYC in the three major breast cancer subtypes and highlight the most promising leads to target MYC functions.\u003C\u002Fjats:p>",{"EN":3806},"MYC-Driven Pathways in Breast Cancer Subtypes",{"VOID":3808},"28696357",{"VOID":3810},"10.3390\u002Fbiom7030053",[31],"https:\u002F\u002Fwww.mdpi.com\u002F2218-273X\u002F7\u002F3\u002F53",[3814,3831,3846,3861],{"id":3815,"sortIndex":32,"researcher":28,"roles":3816,"affiliations":3817,"properties":3826,"displayName":3828,"givenName":28,"familyName":28},"1bd4cf77-755f-45db-8ee6-ccfb07ec9ddd",[],[3818],{"id":3819,"sortIndex":32,"affiliation":3820,"properties":28},"c07826cc-ff3c-4e05-80e8-4e91a594aedc",{"id":3819,"createTime":28,"updateTime":28,"relativeEntities":3821,"slug":28,"properties":3822,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3825,"statistic":28},[],{"title":3823},{"VI":3824},"Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA",[],{"title":3827,"openalex":3829},{"EN":3828},"Yassi Fallah",{"VOID":3830},"A5063718690",{"id":3832,"sortIndex":40,"researcher":28,"roles":3833,"affiliations":3834,"properties":3841,"displayName":3843,"givenName":28,"familyName":28},"abaf211b-b556-4ae7-9931-5fdb4c7bc0e6",[],[3835],{"id":3819,"sortIndex":32,"affiliation":3836,"properties":28},{"id":3819,"createTime":28,"updateTime":28,"relativeEntities":3837,"slug":28,"properties":3838,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3840,"statistic":28},[],{"title":3839},{"VI":3824},[],{"title":3842,"openalex":3844},{"EN":3843},"Janetta Brundage",{"VOID":3845},"A5114173869",{"id":3847,"sortIndex":123,"researcher":28,"roles":3848,"affiliations":3849,"properties":3856,"displayName":3858,"givenName":28,"familyName":28},"33e01eca-fe1e-433c-8f1e-9f3ddfdbfb1b",[],[3850],{"id":3819,"sortIndex":32,"affiliation":3851,"properties":28},{"id":3819,"createTime":28,"updateTime":28,"relativeEntities":3852,"slug":28,"properties":3853,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3855,"statistic":28},[],{"title":3854},{"VI":3824},[],{"title":3857,"openalex":3859},{"EN":3858},"Paul Allegakoen",{"VOID":3860},"A5022697592",{"id":3862,"sortIndex":42,"researcher":28,"roles":3863,"affiliations":3864,"properties":3871,"displayName":3875,"givenName":28,"familyName":28},"d96e8525-1b75-4cd8-9872-97e67df26455",[],[3865],{"id":3819,"sortIndex":32,"affiliation":3866,"properties":28},{"id":3819,"createTime":28,"updateTime":28,"relativeEntities":3867,"slug":28,"properties":3868,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3870,"statistic":28},[],{"title":3869},{"VI":3824},[],{"orcid":3872,"title":3874,"openalex":3876},{"VOID":3873},"https:\u002F\u002Forcid.org\u002F0000-0001-7616-320X",{"EN":3875},"Ayesha N. Shajahan‐Haq",{"VOID":3877},"A5001200228",{"url":28,"publisher":3879,"properties":3925},{"id":868,"createTime":869,"updateTime":870,"relativeEntities":3880,"slug":872,"properties":3881,"entityType":25,"verifyStatus":881,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":32,"subjectFields":3885,"manageAffiliations":3894,"indexDatabases":3905,"url":940,"thumbnailPath":28,"statistic":3920,"gsStatistic":28,"type":28,"analyzePriority":28},[],{"issn":3882,"title":3883,"country":3884},{"VOID":877},{"EN":872},{"VOID":875},[3886,3890],{"id":884,"createTime":28,"updateTime":28,"relativeEntities":3887,"label":3888,"description":3889,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":887},{},{"id":890,"createTime":28,"updateTime":28,"relativeEntities":3891,"label":3892,"description":3893,"parentId":28,"standard":28,"scholarHubFieldId":28},[],{"EN":893},{},[3895,3900],{"id":897,"createTime":28,"updateTime":28,"relativeEntities":3896,"slug":28,"properties":3897,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3899,"statistic":28},[],{"title":3898},{"EN":901},[],{"id":904,"createTime":28,"updateTime":28,"relativeEntities":3901,"slug":28,"properties":3902,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":3904,"statistic":28},[],{"title":3903},{"EN":908},[],[3906,3913],{"id":912,"indexDatabase":3907,"url":918,"indexYears":919,"academicFieldIds":3912,"indexDatabaseRanking":923},{"id":792,"createTime":28,"updateTime":28,"relativeEntities":3908,"label":3909,"description":3910,"key":798,"publicationTags":3911,"standard":28},[],{"EN":795,"VI":795},{"EN":795,"VI":797},[800],[921,922],{"id":925,"indexDatabase":3914,"url":937,"indexYears":28,"academicFieldIds":3919,"indexDatabaseRanking":28},{"id":927,"createTime":28,"updateTime":28,"relativeEntities":3915,"label":3916,"description":3917,"key":934,"publicationTags":3918,"standard":28},[],{"EN":930,"VI":930},{"EN":932,"VI":933},[936,785],[939],{"impactFactor":32,"impactFactorByYear":3921,"i10Index":42,"i10IndexLast5Year":32,"totalPublication":45,"totalPublicationByYear":3922,"totalCitation":944,"totalCitationByYear":3923,"totalCitationPerPublication":946,"totalCitationPerPublicationByYear":3924,"hindexLast5Year":45,"hindex":45},{},{},{},{},{"issue":3926,"pages":3927,"volume":3929},{"VOID":2101},{"VOID":3928},"53",{"VOID":3930},"7",192,{"total":3931,"publishYear":28,"statisticByYear":3933},{"2017":40,"2018":47,"2019":128,"2020":132,"2021":278,"2022":196,"2023":141,"2024":127},[],[3936,3940,3944,3948,3951,3955,3959,3963,3967,3971,3975,3979,3983,3987,3991,3995,3999,4003,4007,4011,4015,4019,4023,4027,4031,4035,4039,4043,4047,4051,4055,4059,4063,4067,4071,4075,4079,4083,4087,4091,4095,4099,4103,4107,4111,4115],{"id":28,"text":3937,"url":28,"identifiers":3938},"Deming, 2000, C-myc amplification in breast cancer: A meta-analysis of its occurrence and prognostic relevance, Br. J. Cancer, 83, 1688, 10.1054\u002Fbjoc.2000.1522",{"doi":3939},"10.1054\u002Fbjoc.2000.1522",{"id":28,"text":3941,"url":28,"identifiers":3942},"Blancato, 2004, Correlation of amplification and overexpression of the c-myc oncogene in high-grade breast cancer: FISH, in situ hybridisation and immunohistochemical analyses, Br. J. Cancer, 90, 1612, 10.1038\u002Fsj.bjc.6601703",{"doi":3943},"10.1038\u002Fsj.bjc.6601703",{"id":28,"text":3945,"url":28,"identifiers":3946},"Prall, 1998, C-Myc or cyclin D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry, Mol. Cell. Biol., 18, 4499, 10.1128\u002FMCB.18.8.4499",{"doi":3947},"10.1128\u002FMCB.18.8.4499",{"id":28,"text":3949,"url":28,"identifiers":3950},"Hanson, 1994, Effects of c-myc expression on cell cycle progression, Mol. Cell. Biol., 14, 5748",{},{"id":28,"text":3952,"url":28,"identifiers":3953},"Meyer, 2008, Reflecting on 25 years with MYC, Nat. Rev. Cancer, 8, 976, 10.1038\u002Fnrc2231",{"doi":3954},"10.1038\u002Fnrc2231",{"id":28,"text":3956,"url":28,"identifiers":3957},"Dang, 2012, MYC on the path to cancer, Cell, 149, 22, 10.1016\u002Fj.cell.2012.03.003",{"doi":3958},"10.1016\u002Fj.cell.2012.03.003",{"id":28,"text":3960,"url":28,"identifiers":3961},"Hartl, 2016, The Quest for Targets Executing MYC-Dependent Cell Transformation, Front. Oncol., 6, 132, 10.3389\u002Ffonc.2016.00132",{"doi":3962},"10.3389\u002Ffonc.2016.00132",{"id":28,"text":3964,"url":28,"identifiers":3965},"Jemal, 2011, Global cancer statistics, CA Cancer J. Clin., 61, 69, 10.3322\u002Fcaac.20107",{"doi":3966},"10.3322\u002Fcaac.20107",{"id":28,"text":3968,"url":28,"identifiers":3969},"Schnipper, 1986, Clinical implications of tumor-cell heterogeneity, N. Engl. J. Med., 314, 1423, 10.1056\u002FNEJM198605293142206",{"doi":3970},"10.1056\u002FNEJM198605293142206",{"id":28,"text":3972,"url":28,"identifiers":3973},"Matsen, 2013, Breast cancer: A review for the general surgeon, JAMA Surg., 148, 971, 10.1001\u002Fjamasurg.2013.3393",{"doi":3974},"10.1001\u002Fjamasurg.2013.3393",{"id":28,"text":3976,"url":28,"identifiers":3977},"Hammond, 2010, American Society of Clinical Oncology\u002FCollege Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer, J. Clin. Oncol., 28, 2784, 10.1200\u002FJCO.2009.25.6529",{"doi":3978},"10.1200\u002FJCO.2009.25.6529",{"id":28,"text":3980,"url":28,"identifiers":3981},"Allegra, 1980, Changes in multiple or sequential estrogen receptor determinations in breast cancer, Cancer, 45, 792, 10.1002\u002F1097-0142(19800215)45:4\u003C792::AID-CNCR2820450430>3.0.CO;2-X",{"doi":3982},"10.1002\u002F1097-0142(19800215)45:4\u003C792::AID-CNCR2820450430>3.0.CO;2-X",{"id":28,"text":3984,"url":28,"identifiers":3985},"Liesenfeld, 2013, Review of mass spectrometry-based metabolomics in cancer research, Cancer Epidemiol. Biomark. Prev., 22, 2182, 10.1158\u002F1055-9965.EPI-13-0584",{"doi":3986},"10.1158\u002F1055-9965.EPI-13-0584",{"id":28,"text":3988,"url":28,"identifiers":3989},"Ward, 2012, Metabolic reprogramming: A cancer hallmark even warburg did not anticipate, Cancer Cell, 21, 297, 10.1016\u002Fj.ccr.2012.02.014",{"doi":3990},"10.1016\u002Fj.ccr.2012.02.014",{"id":28,"text":3992,"url":28,"identifiers":3993},"Anderson, 2002, Estrogen receptor breast cancer phenotypes in the Surveillance, Epidemiology, and End Results database, Breast Cancer Res. Treat., 76, 27, 10.1023\u002FA:1020299707510",{"doi":3994},"10.1023\u002FA:1020299707510",{"id":28,"text":3996,"url":28,"identifiers":3997},"Howell, 2002, Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment, J. Clin. Oncol., 20, 3396, 10.1200\u002FJCO.2002.10.057",{"doi":3998},"10.1200\u002FJCO.2002.10.057",{"id":28,"text":4000,"url":28,"identifiers":4001},"Clarke, 2009, Gene network signaling in hormone responsiveness modifies apoptosis and autophagy in breast cancer cells, J. Steroid Biochem. Mol. Biol., 114, 8, 10.1016\u002Fj.jsbmb.2008.12.023",{"doi":4002},"10.1016\u002Fj.jsbmb.2008.12.023",{"id":28,"text":4004,"url":28,"identifiers":4005},"Clarke, 1994, Hormonal carcinogenesis in breast cancer: Cellular and molecular studies of malignant progression, Breast Cancer Res. Treat., 31, 237, 10.1007\u002FBF00666157",{"doi":4006},"10.1007\u002FBF00666157",{"id":28,"text":4008,"url":28,"identifiers":4009},"Buzdar, 1996, Anastrozole, a potent and selective aromatase inhibitor, versus megestrol acetate in postmenopausal women with advanced breast cancer: Results of overview analysis of two phase III trials. Arimidex Study Group, J. Clin. Oncol., 14, 2000, 10.1200\u002FJCO.1996.14.7.2000",{"doi":4010},"10.1200\u002FJCO.1996.14.7.2000",{"id":28,"text":4012,"url":28,"identifiers":4013},"Shang, 2000, Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription, Cell, 103, 843, 10.1016\u002FS0092-8674(00)00188-4",{"doi":4014},"10.1016\u002FS0092-8674(00)00188-4",{"id":28,"text":4016,"url":28,"identifiers":4017},"Cook, 2014, MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer, Mol. Cancer, 13, 239, 10.1186\u002F1476-4598-13-239",{"doi":4018},"10.1186\u002F1476-4598-13-239",{"id":28,"text":4020,"url":28,"identifiers":4021},"McNeil, 2006, c-Myc overexpression and endocrine resistance in breast cancer, J. Steroid Biochem. Mol. Biol., 102, 147, 10.1016\u002Fj.jsbmb.2006.09.028",{"doi":4022},"10.1016\u002Fj.jsbmb.2006.09.028",{"id":28,"text":4024,"url":28,"identifiers":4025},"Chen, 2015, Cross-talk between ER and HER2 regulates c-MYC-mediated glutamine metabolism in aromatase inhibitor resistant breast cancer cells, J. Steroid Biochem. Mol. Biol., 149, 118, 10.1016\u002Fj.jsbmb.2015.02.004",{"doi":4026},"10.1016\u002Fj.jsbmb.2015.02.004",{"id":28,"text":4028,"url":28,"identifiers":4029},"Wang, 2011, Estrogen induces c-myc gene expression via an upstream enhancer activated by the estrogen receptor and the AP-1 transcription factor, Mol. Endocrinol., 25, 1527, 10.1210\u002Fme.2011-1037",{"doi":4030},"10.1210\u002Fme.2011-1037",{"id":28,"text":4032,"url":28,"identifiers":4033},"Miller, 2011, A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance, Clin. Cancer Res., 17, 2024, 10.1158\u002F1078-0432.CCR-10-2567",{"doi":4034},"10.1158\u002F1078-0432.CCR-10-2567",{"id":28,"text":4036,"url":28,"identifiers":4037},"Sengupta, 2014, Cyclin dependent kinase-9 mediated transcriptional de-regulation of cMYC as a critical determinant of endocrine-therapy resistance in breast cancers, Breast Cancer Res. Treat., 143, 113, 10.1007\u002Fs10549-013-2789-2",{"doi":4038},"10.1007\u002Fs10549-013-2789-2",{"id":28,"text":4040,"url":28,"identifiers":4041},"Butt, 2008, The estrogen and c-Myc target gene HSPC111 is over-expressed in breast cancer and associated with poor patient outcome, Breast Cancer Res., 10, R28, 10.1186\u002Fbcr1985",{"doi":4042},"10.1186\u002Fbcr1985",{"id":28,"text":4044,"url":28,"identifiers":4045},"Zhang, 2014, HSPC111 governs breast cancer growth by regulating ribosomal biogenesis, Mol. Cancer Res., 12, 583, 10.1158\u002F1541-7786.MCR-13-0168",{"doi":4046},"10.1158\u002F1541-7786.MCR-13-0168",{"id":28,"text":4048,"url":28,"identifiers":4049},"Slamon, 1987, Human breast cancer: Correlation of relapse and survival with amplification of the HER-2\u002Fneu oncogene, Science, 235, 177, 10.1126\u002Fscience.3798106",{"doi":4050},"10.1126\u002Fscience.3798106",{"id":28,"text":4052,"url":28,"identifiers":4053},"Hsu, 2016, The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer, Cancer Metastasis Rev., 35, 575, 10.1007\u002Fs10555-016-9649-6",{"doi":4054},"10.1007\u002Fs10555-016-9649-6",{"id":28,"text":4056,"url":28,"identifiers":4057},"Ross, 2009, The HER-2 receptor and breast cancer: Ten years of targeted anti-HER-2 therapy and personalized medicine, Oncologist, 14, 320, 10.1634\u002Ftheoncologist.2008-0230",{"doi":4058},"10.1634\u002Ftheoncologist.2008-0230",{"id":28,"text":4060,"url":28,"identifiers":4061},"Esteva, 2010, Molecular predictors of response to trastuzumab and lapatinib in breast cancer, Nat. Rev. Clin. Oncol., 7, 98, 10.1038\u002Fnrclinonc.2009.216",{"doi":4062},"10.1038\u002Fnrclinonc.2009.216",{"id":28,"text":4064,"url":28,"identifiers":4065},"Gogas, 2016, MYC copy gain, chromosomal instability and PI3K activation as potential markers of unfavourable outcome in trastuzumab-treated patients with metastatic breast cancer, J. Transl. Med., 14, 136, 10.1186\u002Fs12967-016-0883-z",{"doi":4066},"10.1186\u002Fs12967-016-0883-z",{"id":28,"text":4068,"url":28,"identifiers":4069},"Venturutti, 2016, MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1, Oncogene, 35, 6189, 10.1038\u002Fonc.2016.151",{"doi":4070},"10.1038\u002Fonc.2016.151",{"id":28,"text":4072,"url":28,"identifiers":4073},"Collins, 2015, Growth factor receptor\u002Fsteroid receptor cross talk in trastuzumab-treated breast cancer, Oncogene, 34, 525, 10.1038\u002Fonc.2013.586",{"doi":4074},"10.1038\u002Fonc.2013.586",{"id":28,"text":4076,"url":28,"identifiers":4077},"Network, 2012, Comprehensive molecular portraits of human breast tumours, Nature, 490, 61, 10.1038\u002Fnature11412",{"doi":4078},"10.1038\u002Fnature11412",{"id":28,"text":4080,"url":28,"identifiers":4081},"Horiuchi, 2014, Taking on challenging targets: Making MYC druggable, Am. Soc. Clin. Oncol. Educ. Book, 34, e497, 10.14694\u002FEdBook_AM.2014.34.e497",{"doi":4082},"10.14694\u002FEdBook_AM.2014.34.e497",{"id":28,"text":4084,"url":28,"identifiers":4085},"Kaelin, 2005, The concept of synthetic lethality in the context of anticancer therapy, Nat. Rev. Cancer, 5, 689, 10.1038\u002Fnrc1691",{"doi":4086},"10.1038\u002Fnrc1691",{"id":28,"text":4088,"url":28,"identifiers":4089},"Horiuchi, 2012, MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition, J. Exp. Med., 209, 679, 10.1084\u002Fjem.20111512",{"doi":4090},"10.1084\u002Fjem.20111512",{"id":28,"text":4092,"url":28,"identifiers":4093},"Gross, 2014, Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer, Mol. Cancer Ther., 13, 890, 10.1158\u002F1535-7163.MCT-13-0870",{"doi":4094},"10.1158\u002F1535-7163.MCT-13-0870",{"id":28,"text":4096,"url":28,"identifiers":4097},"Knudsen, 2015, RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer, Cell Cycle, 14, 109, 10.4161\u002F15384101.2014.967118",{"doi":4098},"10.4161\u002F15384101.2014.967118",{"id":28,"text":4100,"url":28,"identifiers":4101},"Ren, 2013, MYC overexpression and poor prognosis in sporadic breast cancer with BRCA1 deficiency, Tumour Biol., 34, 3945, 10.1007\u002Fs13277-013-0983-9",{"doi":4102},"10.1007\u002Fs13277-013-0983-9",{"id":28,"text":4104,"url":28,"identifiers":4105},"Camarda, 2016, Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer, Nat. Med., 22, 427, 10.1038\u002Fnm.4055",{"doi":4106},"10.1038\u002Fnm.4055",{"id":28,"text":4108,"url":28,"identifiers":4109},"Shen, 2015, Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP, Proc. Natl. Acad. Sci. USA, 112, 5425, 10.1073\u002Fpnas.1501555112",{"doi":4110},"10.1073\u002Fpnas.1501555112",{"id":28,"text":4112,"url":28,"identifiers":4113},"Pereira, 2016, MYC Amplification as a Predictive Factor of Complete Pathologic Response to Docetaxel-based Neoadjuvant Chemotherapy for Breast Cancer, Clin. Breast Cancer, 17, 188, 10.1016\u002Fj.clbc.2016.12.005",{"doi":4114},"10.1016\u002Fj.clbc.2016.12.005",{"id":28,"text":4116,"url":28,"identifiers":4117},"Pan, 2016, Parabens and Human Epidermal Growth Factor Receptor Ligand Cross-Talk in Breast Cancer Cells, Environ. Health Perspect., 124, 563, 10.1289\u002Fehp.1409200",{"doi":4118},"10.1289\u002Fehp.1409200",{"id":4120,"createTime":4121,"updateTime":4121,"relativeEntities":4122,"slug":4123,"properties":4124,"entityType":972,"verifyStatus":26,"verifyTime":4121,"verifyNote":973,"languages":4139,"translateLanguages":28,"viewCount":32,"primaryUrl":4140,"fullTextUrl":28,"authors":4141,"publicationType":1209,"publisherRelationship":4283,"citationCount":4336,"citationInfo":4337,"publishDate":28,"publishYear":28,"citationAnalyzeStatus":881,"lastCitationAnalyze":28,"indexDatabases":4339,"openAccess":28,"references":4340,"isForceReanalyzing":2008},"a6988025-a7da-4eda-846d-ababa52a42e6","2024-09-26T13:58:43.887+00:00",[],"Melatonin-and-Its-Protective-Role-against-Biotic-Stress-Impacts-on-Plants",{"mag":4125,"pmc":4127,"openalex":4129,"abstract":4131,"title":4133,"pm":4135,"doi":4137},{"VOID":4126},"2996896267",{"VOID":4128},"7022677",{"VOID":4130},"W2996896267",{"EN":4132},"\u003Cjats:p>Biotic stress causes immense damage to agricultural products worldwide and raises the risk of hunger in many areas. Plants themselves tolerate biotic stresses via several pathways, including pathogen-associated molecular patterns (PAMPs), which trigger immunity and plant resistance (R) proteins. On the other hand, humans use several non-ecofriendly methods to control biotic stresses, such as chemical applications. Compared with chemical control, melatonin is an ecofriendly compound that is an economical alternative strategy which can be used to protect animals and plants from attacks via pathogens. In plants, the bactericidal capacity of melatonin was verified against Mycobacterium tuberculosis, as well as multidrug-resistant Gram-negative and -positive bacteria under in vitro conditions. Regarding plant–bacteria interaction, melatonin has presented effective antibacterial activities against phytobacterial pathogens. In plant–fungi interaction models, melatonin was found to play a key role in plant resistance to Botrytis cinerea, to increase fungicide susceptibility, and to reduce the stress tolerance of Phytophthora infestans. In plant–virus interaction models, melatonin not only efficiently eradicated apple stem grooving virus (ASGV) from apple shoots in vitro (making it useful for the production of virus-free plants) but also reduced tobacco mosaic virus (TMV) viral RNA and virus concentration in infected Nicotiana glutinosa and Solanum lycopersicum seedlings. Indeed, melatonin has unique advantages in plant growth regulation and increasing plant resistance effectiveness against different forms of biotic and abiotic stress. Although considerable work has been done regarding the role of melatonin in plant tolerance to abiotic stresses, its role in biotic stress remains unclear and requires clarification. In our review, we summarize the work that has been accomplished so far; highlight melatonin’s function in plant tolerance to pathogens such as bacteria, viruses, and fungi; and determine the direction required for future studies on this topic.\u003C\u002Fjats:p>",{"EN":4134},"Melatonin and Its Protective Role against Biotic Stress Impacts on 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(2010). Why Do Plants Need Defenses?. Plant Defense, Wiley-Blackwell.",{"doi":4344},"10.1002\u002F9781444328547.ch1",{"id":28,"text":4346,"url":28,"identifiers":4347},"Agrios, G.N. (2005). Preface. Plant Pathology, Academic Press. [5th ed.].",{"doi":4348},"10.1016\u002FB978-0-08-047378-9.50004-X",{"id":28,"text":4350,"url":28,"identifiers":4351},"Schumann, G.L., and D’Arcy, C.J. (2010). Essential Plant Pathology, American Phytopathological Society (APS Press).",{},{"id":28,"text":4353,"url":28,"identifiers":4354},"Zaynab, 2018, Role of secondary metabolites in plant defense against pathogens, Microb. Pathog., 124, 198, 10.1016\u002Fj.micpath.2018.08.034",{"doi":4355},"10.1016\u002Fj.micpath.2018.08.034",{"id":28,"text":4357,"url":28,"identifiers":4358},"Monaghan, 2012, Plant pattern recognition receptor complexes at the plasma membrane, Curr. Opin. Plant Boil., 15, 349, 10.1016\u002Fj.pbi.2012.05.006",{"doi":4359},"10.1016\u002Fj.pbi.2012.05.006",{"id":28,"text":4361,"url":28,"identifiers":4362},"Spoel, 2012, How do plants achieve immunity? Defence without specialized immune cells, Nat. Rev. Immunol., 12, 89, 10.1038\u002Fnri3141",{"doi":4363},"10.1038\u002Fnri3141",{"id":28,"text":4365,"url":28,"identifiers":4366},"Xu, 2014, Making sense of hormone-mediated defense networking: From rice to Arabidopsis, Front. Plant Sci., 5, 1",{},{"id":28,"text":4368,"url":28,"identifiers":4369},"Grant, 2006, Systemic immunity, Curr. Opin. Plant Boil., 9, 414, 10.1016\u002Fj.pbi.2006.05.013",{"doi":4370},"10.1016\u002Fj.pbi.2006.05.013",{"id":28,"text":4372,"url":28,"identifiers":4373},"Loon, 1998, Systemic resistance induced by rhizosphere bacteria, Annu. Rev. Phytopathol., 36, 453, 10.1146\u002Fannurev.phyto.36.1.453",{"doi":4374},"10.1146\u002Fannurev.phyto.36.1.453",{"id":28,"text":4376,"url":28,"identifiers":4377},"Santamaria, 2013, Understanding plant defence responses against herbivore attacks: An essential first step towards the development of sustainable resistance against pests, Transgenic Res., 22, 697, 10.1007\u002Fs11248-013-9725-4",{"doi":4378},"10.1007\u002Fs11248-013-9725-4",{"id":28,"text":4380,"url":28,"identifiers":4381},"Oerke, E.C., Dehne, H.W., SchÖNbeck, F., and Weber, A. (1999). Estimated crop losses due to pathogens, animal pests and weeds. Crop Production and Crop Protection, Elsevier.",{"doi":4382},"10.1016\u002FB978-0-444-82095-2.50009-9",{"id":28,"text":4384,"url":28,"identifiers":4385},"Oerke, 2006, Crop losses to pests, J. Agric. Sci., 144, 31, 10.1017\u002FS0021859605005708",{"doi":4386},"10.1017\u002FS0021859605005708",{"id":28,"text":4388,"url":28,"identifiers":4389},"Oerke, 2004, Safeguarding production—losses in major crops and the role of crop protection, Crop. Prot., 23, 275, 10.1016\u002Fj.cropro.2003.10.001",{"doi":4390},"10.1016\u002Fj.cropro.2003.10.001",{"id":28,"text":4392,"url":28,"identifiers":4393},"Savary, 1992, Analysis of crop loss in the multiple pathosystem groundnut-rust- late leaf spot. I. Six experiments, Crop. Prot., 11, 99, 10.1016\u002F0261-2194(92)90091-I",{"doi":4394},"10.1016\u002F0261-2194(92)90091-I",{"id":28,"text":4396,"url":28,"identifiers":4397},"Teng, P.S. (1987). Crop Loss Assessment and Pest Management, APS Press.",{},{"id":28,"text":4399,"url":28,"identifiers":4400},"Wyckhuys, 2019, Biological control of an agricultural pest protects tropical forests, Commun. Boil., 2, 10, 10.1038\u002Fs42003-018-0257-6",{"doi":4401},"10.1038\u002Fs42003-018-0257-6",{"id":28,"text":4403,"url":28,"identifiers":4404},"Lamichhane, 2018, Thirteen decades of antimicrobial copper compounds applied in agriculture. A review, Agron. Sustain. Dev., 38, 28, 10.1007\u002Fs13593-018-0503-9",{"doi":4405},"10.1007\u002Fs13593-018-0503-9",{"id":28,"text":4407,"url":28,"identifiers":4408},"Fortunati, 2019, Sustainable control strategies for plant protection and food packaging sectors by natural substances and novel nanotechnological approaches, J. Sci. Food Agric., 99, 986, 10.1002\u002Fjsfa.9341",{"doi":4409},"10.1002\u002Fjsfa.9341",{"id":28,"text":4411,"url":28,"identifiers":4412},"Lerner, 1958, Isolation of melatonin, the pineal gland factor that lightens melanocytes1, J. Am. Chem. Soc., 80, 2587, 10.1021\u002Fja01543a060",{"doi":4413},"10.1021\u002Fja01543a060",{"id":28,"text":4415,"url":28,"identifiers":4416},"Hattori, 1995, Identification of melatonin in plants and its effects on plasma melatonin levels and binding to melatonin receptors in vertebrates, Biochem. Mol. Boil. Int., 35, 627",{},{"id":28,"text":4418,"url":28,"identifiers":4419},"Dubbels, 1995, Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography-mass spectrometry, J. Pineal Res., 18, 28, 10.1111\u002Fj.1600-079X.1995.tb00136.x",{"doi":4420},"10.1111\u002Fj.1600-079X.1995.tb00136.x",{"id":28,"text":4422,"url":28,"identifiers":4423},"Reiter, 2014, Melatonin: Exceeding Expectations, Physiology, 29, 325, 10.1152\u002Fphysiol.00011.2014",{"doi":4424},"10.1152\u002Fphysiol.00011.2014",{"id":28,"text":4426,"url":28,"identifiers":4427},"Zhao, 2019, Melatonin Synthesis and Function: Evolutionary History in Animals and Plants, Front. Endocrinol., 10, 249, 10.3389\u002Ffendo.2019.00249",{"doi":4428},"10.3389\u002Ffendo.2019.00249",{"id":28,"text":4430,"url":28,"identifiers":4431},"Arnao, 2019, Melatonin: A New Plant Hormone and\u002For a Plant Master Regulator?, Trends Plant Sci., 24, 38, 10.1016\u002Fj.tplants.2018.10.010",{"doi":4432},"10.1016\u002Fj.tplants.2018.10.010",{"id":28,"text":4434,"url":28,"identifiers":4435},"Arnao, 2019, Melatonin and reactive oxygen and nitrogen species: A model for the plant redox network, Melatonin Res., 2, 152, 10.32794\u002F11250036",{"doi":4436},"10.32794\u002F11250036",{"id":28,"text":4438,"url":28,"identifiers":4439},"Ramakrishna, A., and Roshchina, V. (2018). The multi-regulatory properties of melatonin in plants. Neurotransmitters in Plants, CRC Press.",{"doi":4440},"10.1201\u002Fb22467",{"id":28,"text":4442,"url":28,"identifiers":4443},"Back, 2016, Melatonin biosynthesis in plants: Multiple pathways catalyze tryptophan to melatonin in the cytoplasm or chloroplasts, J. Pineal Res., 61, 426, 10.1111\u002Fjpi.12364",{"doi":4444},"10.1111\u002Fjpi.12364",{"id":28,"text":4446,"url":28,"identifiers":4447},"Tan, 2016, On the significance of an alternate pathway of melatonin synthesis via 5-methoxytryptamine: Comparisons across species, J. Pineal Res., 61, 27, 10.1111\u002Fjpi.12336",{"doi":4448},"10.1111\u002Fjpi.12336",{"id":28,"text":4450,"url":28,"identifiers":4451},"Dhole, 2018, Phytomelatonin: A plant hormone for management of stress, J. Anal. Pharm. Res., 7, 1, 10.15406\u002Fjaplr.2018.07.00224",{"doi":4452},"10.15406\u002Fjaplr.2018.07.00224",{"id":28,"text":4454,"url":28,"identifiers":4455},"Kaur, 2015, Regulatory roles of serotonin and melatonin in abiotic stress tolerance in plants, Plant Signal. Behav., 10, e1049788, 10.1080\u002F15592324.2015.1049788",{"doi":4456},"10.1080\u002F15592324.2015.1049788",{"id":28,"text":4458,"url":28,"identifiers":4459},"Vielma, 2014, Effects of melatonin on oxidative stress, and resistance to bacterial, parasitic, and viral infections: A review, Acta Trop., 137, 31, 10.1016\u002Fj.actatropica.2014.04.021",{"doi":4460},"10.1016\u002Fj.actatropica.2014.04.021",{"id":28,"text":4462,"url":28,"identifiers":4463},"Lardone, 2013, Melatonin: Buffering the Immune System, Int. J. Mol. Sci., 14, 8638, 10.3390\u002Fijms14048638",{"doi":4464},"10.3390\u002Fijms14048638",{"id":28,"text":4466,"url":28,"identifiers":4467},"Nabavi, 2019, Anti-inflammatory effects of Melatonin: A mechanistic review, Crit. Rev. Food Sci. Nutr., 59, 4, 10.1080\u002F10408398.2018.1487927",{"doi":4468},"10.1080\u002F10408398.2018.1487927",{"id":28,"text":4470,"url":28,"identifiers":4471},"Regodon, 2005, The use of melatonin as a vaccine agent, Vaccine, 23, 5321, 10.1016\u002Fj.vaccine.2005.07.003",{"doi":4472},"10.1016\u002Fj.vaccine.2005.07.003",{"id":28,"text":4474,"url":28,"identifiers":4475},"Huang, 2019, Melatonin possesses an anti-influenza potential through its immune modulatory effect, J. Funct. Foods, 58, 189, 10.1016\u002Fj.jff.2019.04.062",{"doi":4476},"10.1016\u002Fj.jff.2019.04.062",{"id":28,"text":4478,"url":28,"identifiers":4479},"Boga, 2019, Therapeutic potential of melatonin related to its role as an autophagy regulator: A review, J. Pineal Res., 66, 12534, 10.1111\u002Fjpi.12534",{"doi":4480},"10.1111\u002Fjpi.12534",{"id":28,"text":4482,"url":28,"identifiers":4483},"Zhao, 2019, Exogenous application of melatonin improves plant resistance to virus infection, Plant Pathol., 68, 1287, 10.1111\u002Fppa.13057",{"doi":4484},"10.1111\u002Fppa.13057",{"id":28,"text":4486,"url":28,"identifiers":4487},"Chen, 2019, Exogenous application of melatonin improves eradication of apple stem grooving virus from the infected in vitro shoots by shoot tip culture, Plant Pathol., 68, 997, 10.1111\u002Fppa.13018",{"doi":4488},"10.1111\u002Fppa.13018",{"id":28,"text":4490,"url":28,"identifiers":4491},"Lee, 2015, Arabidopsis serotonin N-acetyltransferase knockout mutant plants exhibit decreased melatonin and salicylic acid levels resulting in susceptibility to an avirulent pathogen, J. Pineal Res., 58, 291, 10.1111\u002Fjpi.12214",{"doi":4492},"10.1111\u002Fjpi.12214",{"id":28,"text":4494,"url":28,"identifiers":4495},"Mandal, 2018, Differential roles of melatonin in plant-host resistance and pathogen suppression in cucurbits, J. Pineal Res., 65, 12505, 10.1111\u002Fjpi.12505",{"doi":4496},"10.1111\u002Fjpi.12505",{"id":28,"text":4498,"url":28,"identifiers":4499},"Weeda, S., Zhang, N., Zhao, X., Ndip, G., Guo, Y., Buck, G.A., Fu, C., and Ren, S. (2014). Arabidopsis Transcriptome Analysis Reveals Key Roles of Melatonin in Plant Defense Systems. PLoS ONE, 9.",{"doi":4500},"10.1371\u002Fjournal.pone.0093462",{"id":28,"text":4502,"url":28,"identifiers":4503},"Qian, 2015, Comparative metabolomic analysis highlights the involvement of sugars and glycerol in melatonin-mediated innate immunity against bacterial pathogen in Arabidopsis, Sci. Rep., 5, 15815, 10.1038\u002Fsrep15815",{"doi":4504},"10.1038\u002Fsrep15815",{"id":28,"text":4506,"url":28,"identifiers":4507},"Shi, 2015, Melatonin induces nitric oxide and the potential mechanisms relate to innate immunity against bacterial pathogen infection in Arabidopsis, J. Pineal Res., 59, 102, 10.1111\u002Fjpi.12244",{"doi":4508},"10.1111\u002Fjpi.12244",{"id":28,"text":4510,"url":28,"identifiers":4511},"Lee, 2014, Melatonin as a signal molecule triggering defense responses against pathogen attack in Arabidopsisand tobacco, J. Pineal Res., 57, 262, 10.1111\u002Fjpi.12165",{"doi":4512},"10.1111\u002Fjpi.12165",{"id":28,"text":4514,"url":28,"identifiers":4515},"Zhao, 2015, Melatonin regulates carbohydrate metabolism and defenses against Pseudomonas syringae pv. tomato DC3000 infection in Arabidopsis thaliana, J. Pineal Res., 59, 109, 10.1111\u002Fjpi.12245",{"doi":4516},"10.1111\u002Fjpi.12245",{"id":28,"text":4518,"url":28,"identifiers":4519},"Arnao, 2018, Melatonin and its relationship to plant hormones, Ann. Bot., 121, 195, 10.1093\u002Faob\u002Fmcx114",{"doi":4520},"10.1093\u002Faob\u002Fmcx114",{"id":28,"text":4522,"url":28,"identifiers":4523},"Lee, 2016, Mitogen-activated protein kinase pathways are required for melatonin-mediated defense responses in plants, J. Pineal Res., 60, 327, 10.1111\u002Fjpi.12314",{"doi":4524},"10.1111\u002Fjpi.12314",{"id":28,"text":4526,"url":28,"identifiers":4527},"Lee, 2017, Melatonin is required for H2O2- and NO-mediated defense signaling through MAPKKK3 and OXI1 in Arabidopsis thaliana, J. Pineal Res., 62, 12379, 10.1111\u002Fjpi.12379",{"doi":4528},"10.1111\u002Fjpi.12379",{"id":28,"text":4530,"url":28,"identifiers":4531},"Arnao, M.B., and Hernández-Ruiz, J. (2019). Melatonin as a Chemical Substance or as Phytomelatonin Rich-Extracts for Use as Plant Protector and\u002For Biostimulant in Accordance with EC Legislation. Agronomy, 9.",{"doi":4532},"10.3390\u002Fagronomy9100570",{"id":28,"text":4534,"url":28,"identifiers":4535},"Aghdam, 2017, Melatonin treatment attenuates postharvest decay and maintains nutritional quality of strawberry fruits (Fragaria×anannasa cv. Selva) by enhancing GABA shunt activity, Food Chem., 221, 1650, 10.1016\u002Fj.foodchem.2016.10.123",{"doi":4536},"10.1016\u002Fj.foodchem.2016.10.123",{"id":28,"text":4538,"url":28,"identifiers":4539},"Yin, 2013, Exogenous melatonin improves Malus resistance to Marssonina apple blotch, J. Pineal Res., 54, 426, 10.1111\u002Fjpi.12038",{"doi":4540},"10.1111\u002Fjpi.12038",{"id":28,"text":4542,"url":28,"identifiers":4543},"Ogur, 2008, Melatonin as an antibiotic: New insights into the actions of this ubiquitous molecule, J. Pineal Res., 44, 222, 10.1111\u002Fj.1600-079X.2007.00516.x",{"doi":4544},"10.1111\u002Fj.1600-079X.2007.00516.x",{"id":28,"text":4546,"url":28,"identifiers":4547},"Wiid, 1999, Potentiation of Isoniazid Activity against Mycobacterium tuberculosis by Melatonin, Antimicrob. Agents Chemother., 43, 975, 10.1128\u002FAAC.43.4.975",{"doi":4548},"10.1128\u002FAAC.43.4.975",{"id":28,"text":4550,"url":28,"identifiers":4551},"Ma, N., Zhang, J., Reiter, R.J., and Ma, X. (2019). Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: A therapeutic target to reduce intestinal inflammation. Med. Res. Rev.",{"doi":4552},"10.1002\u002Fmed.21628",{"id":28,"text":4554,"url":28,"identifiers":4555},"Chen, 2019, Melatonin treatments reduce the pathogenicity and inhibit the growth of Xanthomonas oryzae pv, oryzicola. Plant Patho., 68, 288, 10.1111\u002Fppa.12954",{"doi":4556},"10.1111\u002Fppa.12954",{"id":28,"text":4558,"url":28,"identifiers":4559},"Chen, 2018, Melatonin Treatment Inhibits the Growth of Xanthomonas oryzae pv, oryzae. Front. Microbiol., 9, 2280, 10.3389\u002Ffmicb.2018.02280",{"doi":4560},"10.3389\u002Ffmicb.2018.02280",{"id":28,"text":4562,"url":28,"identifiers":4563},"Nehela, 2018, Infection with phytopathogenic bacterium inhibits melatonin biosynthesis, decreases longevity of its vector, and suppresses the free radical-defense, J. Pineal Res., 65, 12511, 10.1111\u002Fjpi.12511",{"doi":4564},"10.1111\u002Fjpi.12511",{"id":28,"text":4566,"url":28,"identifiers":4567},"Wei, 2018, RAV transcription factors are essential for disease resistance against cassava bacterial blight via activation of melatonin biosynthesis genes, J. Pineal Res., 64, 12454, 10.1111\u002Fjpi.12454",{"doi":4568},"10.1111\u002Fjpi.12454",{"id":28,"text":4570,"url":28,"identifiers":4571},"Yavuz, 2007, Effects of melatonin on Candida sepsis in an experimental rat model, Adv. Ther., 24, 91, 10.1007\u002FBF02849996",{"doi":4572},"10.1007\u002FBF02849996",{"id":28,"text":4574,"url":28,"identifiers":4575},"Terron, 2003, Phagocytosis of Candida albicans and superoxide anion Levels in ring dove (Streptopelia risoria) heterophils: Effect of melatonin, J. Neuroendocr., 15, 1111, 10.1111\u002Fj.1365-2826.2003.01103.x",{"doi":4576},"10.1111\u002Fj.1365-2826.2003.01103.x",{"id":28,"text":4578,"url":28,"identifiers":4579},"Paredes, 2004, Comparative study of the heterophil phagocytic function in young and old ring doves (Streptopelia risoria) and its relationship with melatonin levels, J. Comp. Physiol. B, 174, 421",{},{"id":28,"text":4581,"url":28,"identifiers":4582},"Cengiz, 2012, Melatonin and Oral Cavity, Int. J. Dent., 2012, 1, 10.1155\u002F2012\u002F491872",{"doi":4583},"10.1155\u002F2012\u002F491872",{"id":28,"text":4585,"url":28,"identifiers":4586},"Liu, 2019, Melatonin Induces Disease Resistance to Botrytis cinerea in Tomato Fruit by Activating Jasmonic Acid Signaling Pathway, J. Agric. Food Chem., 67, 6116, 10.1021\u002Facs.jafc.9b00058",{"doi":4587},"10.1021\u002Facs.jafc.9b00058",{"id":28,"text":4589,"url":28,"identifiers":4590},"Zhang, 2017, Melatonin Attenuates Potato Late Blight by Disrupting Cell Growth, Stress Tolerance, Fungicide Susceptibility and Homeostasis of Gene Expression in Phytophthora infestans, Front. Plant Sci., 8, 1993, 10.3389\u002Ffpls.2017.01993",{"doi":4591},"10.3389\u002Ffpls.2017.01993",{"id":28,"text":4593,"url":28,"identifiers":4594},"Chang, 2018, Induced resistance to Plasmodiophora brassicae in Arabidopsis by melatonin, Chin. J. Appl. Environ. Bio., 24, 75",{},{"id":28,"text":4596,"url":28,"identifiers":4597},"Sun, 2019, Effect ofexogenous melatonin on resistance of cucumber to downy mildew, Sci. Hortic., 255, 231, 10.1016\u002Fj.scienta.2019.04.057",{"doi":4598},"10.1016\u002Fj.scienta.2019.04.057",{"id":28,"text":4600,"url":28,"identifiers":4601},"Zhang, 2018, Synergistic anti-oomycete effect of melatonin with a biofungicide against oomycetic black shank disease, J. Pineal Res., 65, 12492, 10.1111\u002Fjpi.12492",{"doi":4602},"10.1111\u002Fjpi.12492",{"id":28,"text":4604,"url":28,"identifiers":4605},"Li, 2018, The mitigation effects of exogenous melatonin on replant disease in apple, J. Pineal Res., 65, 12523, 10.1111\u002Fjpi.12523",{"doi":4606},"10.1111\u002Fjpi.12523",{"id":28,"text":4608,"url":28,"identifiers":4609},"Arnao, 2015, Functions of melatonin in plants: A review, J. Pineal Res., 59, 133, 10.1111\u002Fjpi.12253",{"doi":4610},"10.1111\u002Fjpi.12253",{"id":28,"text":4612,"url":28,"identifiers":4613},"Jiao, 2016, Melatonin-Producing Endophytic Bacteria from Grapevine Roots Promote the Abiotic Stress-Induced Production of Endogenous Melatonin in Their Hosts, Front. Plant Sci., 7, 542, 10.3389\u002Ffpls.2016.01387",{"doi":4614},"10.3389\u002Ffpls.2016.01387",{"id":28,"text":4616,"url":28,"identifiers":4617},"Ma, 2017, Endophytic Bacterium Pseudomonas fluorescens RG11 May Transform Tryptophan to Melatonin and Promote Endogenous Melatonin Levels in the Roots of Four Grape Cultivars, Front. Plant Sci., 7, 305, 10.3389\u002Ffpls.2016.02068",{"doi":4618},"10.3389\u002Ffpls.2016.02068",{"id":28,"text":4620,"url":28,"identifiers":4621},"Zhang, H., Liu, X., Chen, T., Ji, Y., Shi, K., Wang, L., Zheng, X., and Kong, J. (2018). Melatonin in Apples and Juice: Inhibition of Browning and Microorganism Growth in Apple Juice. Molecules, 23.",{"doi":4622},"10.3390\u002Fmolecules23030521",{"id":28,"text":4624,"url":28,"identifiers":4625},"Lin, 2019, Melatonin decreases resistance to postharvest green mold on citrus fruit by scavenging defense-related reactive oxygen species, Postharvest Boil. Technol., 153, 21, 10.1016\u002Fj.postharvbio.2019.03.016",{"doi":4626},"10.1016\u002Fj.postharvbio.2019.03.016",{"id":28,"text":4628,"url":28,"identifiers":4629},"Wei, 2017, Identification, transcriptional and functional analysis of heat-shock protein 90s in banana (Musa acuminata L.) highlight their novel role in melatonin-mediated plant response to Fusarium wilt, J. Pineal Res., 62, 12367, 10.1111\u002Fjpi.12367",{"doi":4630},"10.1111\u002Fjpi.12367",{"id":28,"text":4632,"url":28,"identifiers":4633},"Wei, 2018, Phytomelatonin receptor PMTR1-mediated signaling regulates stomatal closure in Arabidopsis thaliana, J. Pineal Res., 65, 12500, 10.1111\u002Fjpi.12500",{"doi":4634},"10.1111\u002Fjpi.12500",{"id":28,"text":4636,"url":28,"identifiers":4637},"Zhan, H., Nie, X., Zhang, T., Li, S., Wang, X., Du, X., Tong, W., and Song, W. (2019). Melatonin: A Small Molecule but Important for Salt Stress Tolerance in Plants. Int. J. Mol. Sci., 20.",{"doi":4638},"10.3390\u002Fijms20030709",{"id":28,"text":4640,"url":28,"identifiers":4641},"Almoneafy, 2014, Tomato plant growth promotion and antibacterial related-mechanisms of four rhizobacterial Bacillus strains against Ralstonia solanacearum, Symbiosis, 63, 59, 10.1007\u002Fs13199-014-0288-9",{"doi":4642},"10.1007\u002Fs13199-014-0288-9",{"id":28,"text":4644,"url":28,"identifiers":4645},"Almoneafy, 2013, Synergistic effect of acetyl salicylic acid and DL-Beta-aminobutyric acid on biocontrol efficacy of Bacillus strains against tomato bacterial wilt, Trop. 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,6123,6127,6131,6135,6139,6143,6147,6151,6155,6159,6163,6167,6171,6175,6179,6183,6187,6191,6195,6199,6203,6207,6211],{"id":28,"text":4803,"url":28,"identifiers":4804},"Schauenstein, 1963, Ueber die Reaktion von 9,12 Linolsaeureester in Wasser 6. Mitteilung: Chromatographische Untersuchungen ueber die Zusammensetzung des Praeparates LHPO und die Isolierung der einzelnen tumor-wirksamen Hydroperoxid-Komponenten, Chem. Mon., 94, 11, 10.1007\u002FBF00900233",{"doi":4805},"10.1007\u002FBF00900233",{"id":28,"text":4807,"url":28,"identifiers":4808},"Halliwell, B., and Gutteridge, J. (2007). Free Radicals in Biology and Medicine, Oxford University Press. [4th ed.].",{},{"id":28,"text":4810,"url":28,"identifiers":4811},"Catala, 2009, Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and\u002For pathological conditions, Chem. Phys. Lipids, 157, 1, 10.1016\u002Fj.chemphyslip.2008.09.004",{"doi":4812},"10.1016\u002Fj.chemphyslip.2008.09.004",{"id":28,"text":4814,"url":28,"identifiers":4815},"Poli, 2008, 4-Hydroxynonenal: A membrane lipid oxidation product of medicinal interest, Med. Res. Rev., 28, 569, 10.1002\u002Fmed.20117",{"doi":3079},{"id":28,"text":4817,"url":28,"identifiers":4818},"Schaur, 2003, Basic aspects of the biochemical reactivity of 4-hydroxynonenal, Mol. Asp. Med., 24, 149, 10.1016\u002FS0098-2997(03)00009-8",{"doi":4819},"10.1016\u002FS0098-2997(03)00009-8",{"id":28,"text":4821,"url":28,"identifiers":4822},"Dubinina, 2010, Role of 4-hydroxy-trans-2-nonenal in cell functions, Biochem. Moscow, 75, 1069, 10.1134\u002FS0006297910090014",{"doi":4823},"10.1134\u002FS0006297910090014",{"id":28,"text":4825,"url":28,"identifiers":4826},"Fritz, 2013, An overview of the chemistry and biology of reactive aldehydes, Free Rad. Biol. Med., 59, 85, 10.1016\u002Fj.freeradbiomed.2012.06.025",{"doi":4827},"10.1016\u002Fj.freeradbiomed.2012.06.025",{"id":28,"text":4829,"url":28,"identifiers":4830},"Zarkovic, 2013, Pathophysiological relevance of aldehydic protein modifications, J. Proteomics, 92, 239, 10.1016\u002Fj.jprot.2013.02.004",{"doi":4831},"10.1016\u002Fj.jprot.2013.02.004",{"id":28,"text":4833,"url":28,"identifiers":4834},"Perluigi, 2012, 4-hydroxy-2-nonenal, a reactive product of lipid peroxidation, and neurodegenerative diseases: A toxic combination illuminated by redox proteomics studies, Antioxid. Redox Signal., 17, 1590, 10.1089\u002Fars.2011.4406",{"doi":4835},"10.1089\u002Fars.2011.4406",{"id":28,"text":4837,"url":28,"identifiers":4838},"Riahi, 2010, Signaling and cytotoxic functions of 4-hydroxyalkenals, Am. J. Physiol. Endocrinol. Metab., 299, E879, 10.1152\u002Fajpendo.00508.2010",{"doi":4839},"10.1152\u002Fajpendo.00508.2010",{"id":28,"text":4841,"url":28,"identifiers":4842},"Forman, 2010, Reactive oxygen species and α,β-unsaturated aldehydes as second messengers in signal transduction, Oxid. Nitrosative Stress Dis., 1203, 35",{},{"id":28,"text":4844,"url":28,"identifiers":4845},"Higdon, 2012, Cell signalling by reactive lipid species: New concepts and molecular mechanisms, Biochem. J., 442, 453, 10.1042\u002FBJ20111752",{"doi":4846},"10.1042\u002FBJ20111752",{"id":28,"text":4848,"url":28,"identifiers":4849},"Dwivedi, 2007, Role of 4-hydroxynonenal and its metabolites in signaling, Redox Rep., 12, 4, 10.1179\u002F135100007X162211",{"doi":4850},"10.1179\u002F135100007X162211",{"id":28,"text":4852,"url":28,"identifiers":4853},"Ayala, A., Munoz, M.F., and Argueelles, S. (2014). Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid. Med. Cell. Longev.",{"doi":4854},"10.1155\u002F2014\u002F360438",{"id":28,"text":4856,"url":28,"identifiers":4857},"Spickett, 2013, The lipid peroxidation product 4-hydroxy-2-nonenal: Advances in chemistry and analysis, Redox Biol., 1, 145, 10.1016\u002Fj.redox.2013.01.007",{"doi":4858},"10.1016\u002Fj.redox.2013.01.007",{"id":28,"text":4860,"url":28,"identifiers":4861},"LoPachin, 2009, Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: Nucleophilic targets and adduct formation, Chem. Res. Toxicol., 22, 1499, 10.1021\u002Ftx900147g",{"doi":4862},"10.1021\u002Ftx900147g",{"id":28,"text":4864,"url":28,"identifiers":4865},"Mattson, 2009, Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders, Exp. Gerontol., 44, 625, 10.1016\u002Fj.exger.2009.07.003",{"doi":4866},"10.1016\u002Fj.exger.2009.07.003",{"id":28,"text":4868,"url":28,"identifiers":4869},"Guichardant, 2009, Analysis of biomarkers from lipid peroxidation: A comparative study, Eur. J. Lipid Sci. Technol., 111, 75, 10.1002\u002Fejlt.200800069",{"doi":4870},"10.1002\u002Fejlt.200800069",{"id":28,"text":4872,"url":28,"identifiers":4873},"Pryor, W.A. (1980). Free Radicals in Biology, Academic Press.",{},{"id":28,"text":4875,"url":28,"identifiers":4876},"Aikens, 1991, Perhydroxyl radical (HOO.) initiated lipid-peroxidation—The role of fatty-acid hydroperoxides, J. Biol. Chem., 266, 15091, 10.1016\u002FS0021-9258(18)98591-1",{"doi":4877},"10.1016\u002FS0021-9258(18)98591-1",{"id":28,"text":4879,"url":28,"identifiers":4880},"Tsunada, 2003, Chronic exposure to subtoxic levels of peroxidized lipids suppresses mucosal cell turnover in rat small intestine and reversal by glutathione, Dig. Dis. Sci., 48, 210, 10.1023\u002FA:1021775524062",{"doi":4881},"10.1023\u002FA:1021775524062",{"id":28,"text":4883,"url":28,"identifiers":4884},"Bochkov, 2002, Protective role of phospholipid oxidation products in endotoxin-induced tissue damage, Nature, 419, 77, 10.1038\u002Fnature01023",{"doi":4885},"10.1038\u002Fnature01023",{"id":28,"text":4887,"url":28,"identifiers":4888},"Yin, 2004, Identification of a novel class of endoperoxides from arachidonate autoxidation, J. Biol. Chem., 279, 3766, 10.1074\u002Fjbc.M307137200",{"doi":4889},"10.1074\u002Fjbc.M307137200",{"id":28,"text":4891,"url":28,"identifiers":4892},"Poli, 2000, 4-Hydroxynonenal in the pathomechanisms of oxidative stress, Iubmb Life, 50, 315",{},{"id":28,"text":4894,"url":28,"identifiers":4895},"Pillon, 2010, Quantitative structure-activity relationship for 4-hydroxy-2-alkenal induced cytotoxicity in L6 muscle cells, Chem. Biol. Interact., 188, 171, 10.1016\u002Fj.cbi.2010.06.015",{"doi":4896},"10.1016\u002Fj.cbi.2010.06.015",{"id":28,"text":4898,"url":28,"identifiers":4899},"Vazdar, 2012, Behavior of 4-hydroxynonenal in phospholipid membranes, J. Phys. Chem. B, 116, 6411, 10.1021\u002Fjp3044219",{"doi":4900},"10.1021\u002Fjp3044219",{"id":28,"text":4902,"url":28,"identifiers":4903},"Dabrowski, 2010, Stereoselective Effects of 4-hydroxynonenal in cultured mouse hepatocytes, Chem. Res. Toxicol., 23, 1601, 10.1021\u002Ftx100190k",{"doi":4904},"10.1021\u002Ftx100190k",{"id":28,"text":4906,"url":28,"identifiers":4907},"Hiratsuka, 2001, (S)-preferential cytotoxicity of 4-hydroxy-2(E)-nonenal enantiomers in rat Clone 9 cells, Toxicology, 164, 199",{},{"id":28,"text":4909,"url":28,"identifiers":4910},"Gueraud, 2005, Enantioselective metabolism of (R)- and (S)-4-hydroxy-2-nonenal in rat, Biofactors, 24, 97, 10.1002\u002Fbiof.5520240111",{"doi":4911},"10.1002\u002Fbiof.5520240111",{"id":28,"text":4913,"url":28,"identifiers":4914},"Sadhukhan, 2014, Glutathionylated 4-hydroxy-2-(E)-alkenal enantiomers in rat organs and their contributions toward the disposal of 4-hydroxy-2-(E)-nonenal in rat liver, Free Rad. Biol. Med., 70, 78, 10.1016\u002Fj.freeradbiomed.2014.02.008",{"doi":4915},"10.1016\u002Fj.freeradbiomed.2014.02.008",{"id":28,"text":4917,"url":28,"identifiers":4918},"Wakita, 2009, Stereochemical configuration of 4-hydroxy-2-nonenal-cysteine adducts and their stereoselective formation in a redox-regulated protein, J. Biol. Chem., 284, 28810, 10.1074\u002Fjbc.M109.019927",{"doi":4919},"10.1074\u002Fjbc.M109.019927",{"id":28,"text":4921,"url":28,"identifiers":4922},"Komisarski, 2009, Practical highly enantioselective synthesis of (R)- and (S)-(E)-4-hydroxynon-2-enal, Acta Biochim. Polonica, 56, 189, 10.18388\u002Fabp.2009_2532",{"doi":4923},"10.18388\u002Fabp.2009_2532",{"id":28,"text":4925,"url":28,"identifiers":4926},"Yadav, U.C.S., and Ramana, K.V. (2013). Regulation of NF-kappaB-induced inflammatory signaling by lipid peroxidation-derived aldehydes. Oxid. Med. Cell. Longevity.",{"doi":4927},"10.1155\u002F2013\u002F690545",{"id":28,"text":4929,"url":28,"identifiers":4930},"Singh, 2009, Fat accumulation in Caenorhabditis elegans triggered by the electrophilic lipid peroxidation product 4-Hydroxynonenal (4-HNE), Aging, 1, 68, 10.18632\u002Faging.100005",{"doi":4931},"10.18632\u002Faging.100005",{"id":28,"text":4933,"url":28,"identifiers":4934},"Singh, 2008, Role of the electrophilic lipid peroxidation product 4-hydroxynonenal in the development and maintenance of obesity in mice, Biochemistry, 47, 3900, 10.1021\u002Fbi702124u",{"doi":4935},"10.1021\u002Fbi702124u",{"id":28,"text":4937,"url":28,"identifiers":4938},"Schneider, C., and Brash, A.R. (2013). Monomeric and dimeric routes to formation of 4-hydroxynonenal during lipid peroxidation. Abstr. Papers Am. Chem. Soc., 246, Abstract 41-AGFD.",{},{"id":28,"text":4940,"url":28,"identifiers":4941},"Long, 2010, Trans-4-hydroxy-2-hexenal, a product of n-3 fatty acid peroxidation: Make some room HNE, Free Rad. Biol. Med., 49, 1, 10.1016\u002Fj.freeradbiomed.2010.03.015",{"doi":4942},"10.1016\u002Fj.freeradbiomed.2010.03.015",{"id":28,"text":4944,"url":28,"identifiers":4945},"Wang, 2013, Cyclooxygenase-2 generates the endogenous mutagen trans-4-hydroxy-2-nonenal in Enterococcus faecalis-infected macrophages, Cancer Prev. Res., 6, 206, 10.1158\u002F1940-6207.CAPR-12-0350",{"doi":4946},"10.1158\u002F1940-6207.CAPR-12-0350",{"id":28,"text":4948,"url":28,"identifiers":4949},"Kang, 2011, Hepatotoxicity and nephrotoxicity produced by 4-hydroxy-2-nonenal (4-HNE) following 4-week oral administration to sprague-dawley rats, J. Toxicol. Environ. Health Part A, 74, 779, 10.1080\u002F15287394.2011.567952",{"doi":4950},"10.1080\u002F15287394.2011.567952",{"id":28,"text":4952,"url":28,"identifiers":4953},"Zhang, 2010, 4-Hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathway, J. Mol. Cell. Cardiol., 49, 576, 10.1016\u002Fj.yjmcc.2010.05.011",{"doi":4954},"10.1016\u002Fj.yjmcc.2010.05.011",{"id":28,"text":4956,"url":28,"identifiers":4957},"Mannervik, 2012, Five decades with glutathione and the GSTome, J. Biol. Chem., 287, 6072, 10.1074\u002Fjbc.X112.342675",{"doi":4958},"10.1074\u002Fjbc.X112.342675",{"id":28,"text":4960,"url":28,"identifiers":4961},"Balogh, 2011, Interactions of glutathione transferases with 4-hydroxynonenal, Drug Metab. Rev., 43, 165, 10.3109\u002F03602532.2011.558092",{"doi":4962},"10.3109\u002F03602532.2011.558092",{"id":28,"text":4964,"url":28,"identifiers":4965},"Rudd, 2011, Enhanced glutathione depletion, protein adduct formation, and cytotoxicity following exposure to 4-hydroxy-2-nonenal (HNE) in cells expressing human multidrug resistance protein-1 (MRP1) together with human glutathione S-transferase-M1 (GSTM1), Chem. Biol. Interact., 194, 113, 10.1016\u002Fj.cbi.2011.08.012",{"doi":4966},"10.1016\u002Fj.cbi.2011.08.012",{"id":28,"text":4968,"url":28,"identifiers":4969},"Shireman, 2010, Glutathione transferase A4-4 resists adduction by 4-hydroxynonenal, Arch. Biochem. Biophys., 504, 182, 10.1016\u002Fj.abb.2010.09.005",{"doi":4970},"10.1016\u002Fj.abb.2010.09.005",{"id":28,"text":4972,"url":28,"identifiers":4973},"Zhou, 1999, Ability of carnosine and other skeletal muscle components to quench unsaturated aldehydic lipid oxidation products, J. Agric. Food Chem., 47, 51, 10.1021\u002Fjf980780j",{"doi":4974},"10.1021\u002Fjf980780j",{"id":28,"text":4976,"url":28,"identifiers":4977},"Shearn, 2013, Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis, Free Rad. Biol. Med., 65, 680, 10.1016\u002Fj.freeradbiomed.2013.07.011",{"doi":4978},"10.1016\u002Fj.freeradbiomed.2013.07.011",{"id":28,"text":4980,"url":28,"identifiers":4981},"Zhu, 2009, Natural polyphenols as direct trapping agents of lipid peroxidation-derived acrolein and 4-hydroxy-trans-2-nonenal, Chem. Res. Toxicol., 22, 1721, 10.1021\u002Ftx900221s",{"doi":4982},"10.1021\u002Ftx900221s",{"id":28,"text":4984,"url":28,"identifiers":4985},"Stevens, J.F., Sowell, J.D., and Frei, B. Ascorbic Acid Conjugates. (US20090104705A1), US Patent.",{},{"id":28,"text":4987,"url":28,"identifiers":4988},"Aldini, G., Yeum, K.J., Niki, E., and Russell, R.M. (2010). Biomarkers for Antioxidative Defense and Oxidative Damage, Blackwell Publishing.",{"doi":4989},"10.1002\u002F9780813814438",{"id":28,"text":4991,"url":28,"identifiers":4992},"Wakita, 2011, A method for detection of 4-hydroxy-2-nonenal adducts in proteins, Free Radic. Biol. Med., 51, 1, 10.1016\u002Fj.freeradbiomed.2011.02.037",{"doi":4993},"10.1016\u002Fj.freeradbiomed.2011.02.037",{"id":28,"text":4995,"url":28,"identifiers":4996},"Zhang, 2011, Relating protein adduction to gene expression changes: A systems approach, Mol. Biosyst., 7, 2118, 10.1039\u002Fc1mb05014a",{"doi":4997},"10.1039\u002Fc1mb05014a",{"id":28,"text":4999,"url":28,"identifiers":5000},"Dick, 2001, Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal\u002Fone oxidoreductase—A new role for leukotriene B-4 12-hydroxydehydrogenase\u002F15-oxoprostaglandin 13-reductase, J. Biol. Chem., 276, 40803, 10.1074\u002Fjbc.M105487200",{"doi":5001},"10.1074\u002Fjbc.M105487200",{"id":28,"text":5003,"url":28,"identifiers":5004},"Chen, 1996, Epoxidation of trans-4-hydroxy-2-nonenal by fatty acid hydroperoxides and hydrogen peroxide, Chem. Res. Toxicol., 9, 306, 10.1021\u002Ftx9501389",{"doi":5005},"10.1021\u002Ftx9501389",{"id":28,"text":5007,"url":28,"identifiers":5008},"Perry, 2013, Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links, Free Radic. Res., 47, 507, 10.3109\u002F10715762.2013.794265",{"doi":5009},"10.3109\u002F10715762.2013.794265",{"id":28,"text":5011,"url":28,"identifiers":5012},"Singh, 2013, Phenelzine mitochondrial functional preservation and neuroprotection after traumatic brain injury related to scavenging of the lipid peroxidation-derived aldehyde 4-hydroxy-2-nonenal, J. Cerebral Blood Flow Metab., 33, 593, 10.1038\u002Fjcbfm.2012.211",{"doi":5013},"10.1038\u002Fjcbfm.2012.211",{"id":28,"text":5015,"url":28,"identifiers":5016},"Fournet, 2013, α,β-Acetylenic amino thiolester inhibitors of aldehyde dehydrogenases 1&3: Suppressors of apoptogenic aldehyde oxidation and activators of apoptosis, Curr. Med. Chem., 20, 527",{},{"id":28,"text":5018,"url":28,"identifiers":5019},"Guo, 2013, ALDH2 protects against stroke by clearing 4-HNE, Cell Res., 23, 915, 10.1038\u002Fcr.2013.69",{"doi":5020},"10.1038\u002Fcr.2013.69",{"id":28,"text":5022,"url":28,"identifiers":5023},"Ma, 2011, Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia\u002Freperfusion injury: Role of autophagy paradox and toxic aldehyde, Eur. Heart J., 32, 1025, 10.1093\u002Feurheartj\u002Fehq253",{"doi":5024},"10.1093\u002Feurheartj\u002Fehq253",{"id":28,"text":5026,"url":28,"identifiers":5027},"Muzio, 2012, Aldehyde dehydrogenases and cell proliferation, Free Radic. Biol. Med., 52, 735, 10.1016\u002Fj.freeradbiomed.2011.11.033",{"doi":5028},"10.1016\u002Fj.freeradbiomed.2011.11.033",{"id":28,"text":5030,"url":28,"identifiers":5031},"Townsend, 2001, Selective protection by stably transfected human ALDH3A1 (but not human ALDH1A1) against toxicity of aliphatic aldehydes in V79 cells, Chem. Biol. Interact., 130–132, 261, 10.1016\u002FS0009-2797(00)00270-2",{"doi":5032},"10.1016\u002FS0009-2797(00)00270-2",{"id":28,"text":5034,"url":28,"identifiers":5035},"Black, 2012, Molecular mechanisms of ALDH3A1-mediated cellular protection against 4-hydroxy-2-nonenal, Free Radic. Biol. Med., 52, 1937, 10.1016\u002Fj.freeradbiomed.2012.02.050",{"doi":5036},"10.1016\u002Fj.freeradbiomed.2012.02.050",{"id":28,"text":5038,"url":28,"identifiers":5039},"2012, Differences in susceptibility to inactivation of human aldehyde dehydrogenases by lipid peroxidation byproducts, Chem. Res. Toxicol., 25, 722, 10.1021\u002Ftx2005184",{"doi":5040},"10.1021\u002Ftx2005184",{"id":28,"text":5042,"url":28,"identifiers":5043},"Murakami, 2009, Cytoprotective role of mitochondrial amyloid beta peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde, Neurobiol. Aging, 30, 325, 10.1016\u002Fj.neurobiolaging.2007.07.002",{"doi":5044},"10.1016\u002Fj.neurobiolaging.2007.07.002",{"id":28,"text":5046,"url":28,"identifiers":5047},"Srivastava, 2009, Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein e-null mice, Circ. Res., 105, 793, 10.1161\u002FCIRCRESAHA.109.200568",{"doi":5048},"10.1161\u002FCIRCRESAHA.109.200568",{"id":28,"text":5050,"url":28,"identifiers":5051},"Keith, 2009, Aldose reductase decreases endoplasmic reticulum stress in ischemic hearts, Chem. Biol. Interact., 178, 242, 10.1016\u002Fj.cbi.2008.10.055",{"doi":5052},"10.1016\u002Fj.cbi.2008.10.055",{"id":28,"text":5054,"url":28,"identifiers":5055},"Li, 2012, Human aldo-keto reductase AKR7A2 protects against the cytotoxicity and mutagenicity of reactive aldehydes and lowers intracellular reactive oxygen species in hamster V79-4 cells, Chem. Biol. Interact., 195, 25, 10.1016\u002Fj.cbi.2011.09.007",{"doi":5056},"10.1016\u002Fj.cbi.2011.09.007",{"id":28,"text":5058,"url":28,"identifiers":5059},"Jung, K.-A., and Kwak, M.-K. (2013). Enhanced 4-hydroxynonenal resistance in KEAP1 silenced human colon cancer cells. Oxid. Med. Cell. Longevity.",{"doi":5060},"10.1155\u002F2013\u002F423965",{"id":28,"text":5062,"url":28,"identifiers":5063},"Lyon, 2013, Aldo-keto reductases mediate constitutive and inducible protection against aldehyde toxicity in human neuroblastoma SH-SY5Y cells, Neurochem. Int., 62, 113, 10.1016\u002Fj.neuint.2012.10.007",{"doi":5064},"10.1016\u002Fj.neuint.2012.10.007",{"id":28,"text":5066,"url":28,"identifiers":5067},"Zhong, 2009, Aldo-keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels, Biochem. Biophys. Res. Commun., 387, 245, 10.1016\u002Fj.bbrc.2009.06.123",{"doi":5068},"10.1016\u002Fj.bbrc.2009.06.123",{"id":28,"text":5070,"url":28,"identifiers":5071},"Martin, 2009, Role of human aldo-keto-reductase AKR1B10 in the protection against toxic aldehydes, Chem. Biol. Interact., 178, 145, 10.1016\u002Fj.cbi.2008.10.021",{"doi":5072},"10.1016\u002Fj.cbi.2008.10.021",{"id":28,"text":5074,"url":28,"identifiers":5075},"Endo, 2010, Properties and tissue distribution of a novel aldo-keto reductase encoding in a rat gene (Akr1b10), Arch. Biochem. Biophys., 503, 230, 10.1016\u002Fj.abb.2010.08.010",{"doi":5076},"10.1016\u002Fj.abb.2010.08.010",{"id":28,"text":5078,"url":28,"identifiers":5079},"Matsunaga, 2011, Protective effect of rat aldo-keto reductase (AKR1C15) on endothelial cell damage elicited by 4-hydroxy-2-nonenal, Chem. Biol. Interact., 191, 364, 10.1016\u002Fj.cbi.2010.12.018",{"doi":5080},"10.1016\u002Fj.cbi.2010.12.018",{"id":28,"text":5082,"url":28,"identifiers":5083},"Marchette, 2010, Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells, Free Radic. Biol. Med., 48, 16, 10.1016\u002Fj.freeradbiomed.2009.08.005",{"doi":5084},"10.1016\u002Fj.freeradbiomed.2009.08.005",{"id":28,"text":5086,"url":28,"identifiers":5087},"Amunom, 2011, Cytochromes p450 catalyze the reduction of α,β-unsaturated aldehydes, Chem. Res. Toxicol., 24, 1223, 10.1021\u002Ftx200080b",{"doi":5088},"10.1021\u002Ftx200080b",{"id":28,"text":5090,"url":28,"identifiers":5091},"Zhang, 2009, Catabolism of 4-hydroxyacids and 4-hydroxynonenal via 4-hydroxy-4-phosphoacyl-CoAs, J. Biol. Chem., 284, 33521, 10.1074\u002Fjbc.M109.055665",{"doi":5092},"10.1074\u002Fjbc.M109.055665",{"id":28,"text":5094,"url":28,"identifiers":5095},"Berthiaume, J.M., Li, Q., Sadhukhan, S., Henry, F., Tochtrop, G.P., Brunengraber, H., and Zhang, G. (2013). Catabolism of 4-hydroxy-2(E)-nonenal (HNE) via omega oxidation in perfused rat livers. FASEB J., 27, Abstract No. 794.15.",{"doi":5096},"10.1096\u002Ffasebj.27.1_supplement.794.15",{"id":28,"text":5098,"url":28,"identifiers":5099},"Subramaniam, 1997, The lipid peroxidation product, 4-hydroxy-2-trans-nonenal, alters the conformation of cortical synaptosomal membrane proteins, J. Neurochem., 69, 1161, 10.1046\u002Fj.1471-4159.1997.69031161.x",{"doi":5100},"10.1046\u002Fj.1471-4159.1997.69031161.x",{"id":28,"text":5102,"url":28,"identifiers":5103},"Chen, 1994, Alterations in mitochondrial-membrane fluidity by lipid-peroxidation products, Free Radic. Biol. Med., 17, 411, 10.1016\u002F0891-5849(94)90167-8",{"doi":5104},"10.1016\u002F0891-5849(94)90167-8",{"id":28,"text":5106,"url":28,"identifiers":5107},"Barrier, 1999, Origin of 4-hydroxynonenal incubation-induced inhibition of dopamine transporter and Na+\u002FK+ adenosine triphosphate in rat striatal synaptosomes, Neurosci. Lett., 277, 91, 10.1016\u002FS0304-3940(99)00652-7",{"doi":5108},"10.1016\u002FS0304-3940(99)00652-7",{"id":28,"text":5110,"url":28,"identifiers":5111},"Liu, 2013, RNA-seq data analysis at the gene and CDS levels provides a comprehensive view of transcriptome responses induced by 4-hydroxynonenal, Mol. Biosyst., 9, 3036, 10.1039\u002Fc3mb70114j",{"doi":5112},"10.1039\u002Fc3mb70114j",{"id":28,"text":5114,"url":28,"identifiers":5115},"Schreier, 2010, Hydrogen sulfide scavenges the cytotoxic lipid oxidation product 4-HNE, Neurotox. Res., 17, 249, 10.1007\u002Fs12640-009-9099-9",{"doi":5116},"10.1007\u002Fs12640-009-9099-9",{"id":28,"text":5118,"url":28,"identifiers":5119},"Siems, 2003, Intracellular metabolism of 4-hydroxynonenal, Mol. Asp. Med., 24, 167, 10.1016\u002FS0098-2997(03)00011-6",{"doi":5120},"10.1016\u002FS0098-2997(03)00011-6",{"id":28,"text":5122,"url":28,"identifiers":5123},"Vila, 2008, Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives, Chem. Res. Toxicol., 21, 432, 10.1021\u002Ftx700347w",{"doi":5124},"10.1021\u002Ftx700347w",{"id":28,"text":5126,"url":28,"identifiers":5127},"Tallman, K.A., Vila, A., Porter, N.A., and Marnett, L.J. (2009). Measuring electrophile stress. Curr. Protoc. Toxicol., 11–17.",{"doi":5128},"10.1002\u002F0471140856.tx1711s40",{"id":28,"text":5130,"url":28,"identifiers":5131},"Chavez, 2010, Site-specific protein adducts of 4-hydroxy-2(E)-nonenal in human THP-1 monocytic cells: Protein carbonylation is diminished by ascorbic acid, Chem. Res. Toxicol., 23, 37, 10.1021\u002Ftx9002462",{"doi":5132},"10.1021\u002Ftx9002462",{"id":28,"text":5134,"url":28,"identifiers":5135},"Codreanu, 2009, Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal, Mol. Cell. Proteomics, 8, 670, 10.1074\u002Fmcp.M800070-MCP200",{"doi":5136},"10.1074\u002Fmcp.M800070-MCP200",{"id":28,"text":5138,"url":28,"identifiers":5139},"Petersen, D.R., Carbone, D., and Doorn, J. (2006, January 16–18). Hepatocellular targets of 4-hydroxy-2-nonenal modification. Proceedings of the 3rd International Meeting of the HNE-Club, Genova, Italy. Abstract No. 6.",{},{"id":28,"text":5141,"url":28,"identifiers":5142},"Hussain, 2006, Modifications of proteins by 4-hydroxy-2-nonenal in the ventilatory muscles of rats, Am. J. Physiol. Lung Cell. Mol. Physiol., 290, L996, 10.1152\u002Fajplung.00337.2005",{"doi":5143},"10.1152\u002Fajplung.00337.2005",{"id":28,"text":5145,"url":28,"identifiers":5146},"Jung, 2005, Distribution of oxidized and HNE-modified proteins in U87 cells, Biofactors, 24, 165, 10.1002\u002Fbiof.5520240120",{"doi":5147},"10.1002\u002Fbiof.5520240120",{"id":28,"text":5149,"url":28,"identifiers":5150},"Carbone, 2005, Modification of heat shock protein 90 by 4-hydroxynonenal in a rat model of chronic alcoholic liver disease, J. Pharmacol. Exp. Ther., 315, 8, 10.1124\u002Fjpet.105.088088",{"doi":5151},"10.1124\u002Fjpet.105.088088",{"id":28,"text":5153,"url":28,"identifiers":5154},"Carbone, 2004, Inhibition of Hsp72-mediated protein refolding by 4-hydroxy-2-nonenal, Chem. Res. Toxicol., 17, 1459, 10.1021\u002Ftx049838g",{"doi":5155},"10.1021\u002Ftx049838g",{"id":28,"text":5157,"url":28,"identifiers":5158},"Legards, J.F., and des Rosiers, C. (2006, January 16–18). Assay of 4-hydroxynonenal (HNE) adducts with various polyaminoacids (PAA) using gas chromatography-mass spectrometry (GCMS). Proceedings of the 3rd International Meeting of the HNE-Club, Genova, Italy.",{},{"id":28,"text":5160,"url":28,"identifiers":5161},"Doorn, 2003, Covalent adduction of nucleophilic amino acids by 4-hydroxynonenal and 4-oxononenal, Chem. Biol. Interact., 143, 93, 10.1016\u002FS0009-2797(02)00178-3",{"doi":5162},"10.1016\u002FS0009-2797(02)00178-3",{"id":28,"text":5164,"url":28,"identifiers":5165},"Isom, 2004, Modification of cytochrome c by 4-hydroxy-2-nonenal: Evidence for histidine, lysine, and arginine-aldehyde adducts, J. Am. Soc. Mass Spectrom., 15, 1136, 10.1016\u002Fj.jasms.2004.03.013",{"doi":5166},"10.1016\u002Fj.jasms.2004.03.013",{"id":28,"text":5168,"url":28,"identifiers":5169},"Liu, 2003, Mass spectroscopic characterization of protein modification by 4-Hydroxy-2-(E)-nonenal and 4-Oxo-2-(E)-nonenal, Chem. Res. Toxicol., 16, 901, 10.1021\u002Ftx0300030",{"doi":5170},"10.1021\u002Ftx0300030",{"id":28,"text":5172,"url":28,"identifiers":5173},"Aldini, 2005, Covalent modification of actin by 4-hydroxy-trans-2-nonenal (HNE): LC-ESI-MS\u002FMS evidence for Cys374 Michael adduction, J. Mass Spectrom., 40, 946, 10.1002\u002Fjms.872",{"doi":5174},"10.1002\u002Fjms.872",{"id":28,"text":5176,"url":28,"identifiers":5177},"Bennaars-Eiden, A., Higgins, L.A., Hertzel, A.V., Kapphahn, R.J., Ferrington, D., and Bernlohr, D.A. (2003). Covalent modification of epithelial fatty acid binding protein by 4-hydroxynonenal in vitro and in vivo: Evidence for a role in antioxidant biology. FASEB J., 17, Abstract No. 845.847.",{"doi":5178},"10.1074\u002Fjbc.M209493200",{"id":28,"text":5180,"url":28,"identifiers":5181},"Carbone, 2005, Cysteine modification by lipid peroxidation products inhibits protein disulfide isomerase, Chem. Res. Toxicol., 18, 1324, 10.1021\u002Ftx050078z",{"doi":5182},"10.1021\u002Ftx050078z",{"id":28,"text":5184,"url":28,"identifiers":5185},"Asselin, 2006, Circulating 4-hydroxynonenal-protein thioether adducts assessed by gas chromatography-mass spectrometry are increased with disease progression and aging in spontaneously hypertensive rats, Free Radic. Biol. Med., 41, 97, 10.1016\u002Fj.freeradbiomed.2006.03.011",{"doi":5186},"10.1016\u002Fj.freeradbiomed.2006.03.011",{"id":28,"text":5188,"url":28,"identifiers":5189},"Moreau, 2005, Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats, Biochem. Pharmacol., 69, 29, 10.1016\u002Fj.bcp.2004.09.006",{"doi":5190},"10.1016\u002Fj.bcp.2004.09.006",{"id":28,"text":5192,"url":28,"identifiers":5193},"Kim, 2006, Proteomic analysis of nitrated and 4-hydroxy-2-nonenal-modified serum proteins during aging, J. Gerontol. Ser. A Biol. Sci. Med. Sci., 61, 332, 10.1093\u002Fgerona\u002F61.4.332",{"doi":5194},"10.1093\u002Fgerona\u002F61.4.332",{"id":28,"text":5196,"url":28,"identifiers":5197},"Petersen, 2004, Reactions of 4-hydroxynonenal with proteins and cellular targets, Free Radic. Biol.Med., 37, 937, 10.1016\u002Fj.freeradbiomed.2004.06.012",{"doi":5198},"10.1016\u002Fj.freeradbiomed.2004.06.012",{"id":28,"text":5200,"url":28,"identifiers":5201},"Renner, 2005, Formation of 4-hydroxy-2-nonenal protein adducts in the ischemic rat heart after transplantation, J. Heart Lung Transpl., 24, 730, 10.1016\u002Fj.healun.2004.02.021",{"doi":5202},"10.1016\u002Fj.healun.2004.02.021",{"id":28,"text":5204,"url":28,"identifiers":5205},"Galligan, 2012, Protein carbonylation in a murine model for early alcoholic liver disease, Chem. Res. Toxicol., 25, 1012, 10.1021\u002Ftx300002q",{"doi":5206},"10.1021\u002Ftx300002q",{"id":28,"text":5208,"url":28,"identifiers":5209},"Aoyama, 2006, Aging and oxidative stress in progressive supranuclear palsy, Eur. J. Neurol., 13, 89, 10.1111\u002Fj.1468-1331.2006.01139.x",{"doi":5210},"10.1111\u002Fj.1468-1331.2006.01139.x",{"id":28,"text":5212,"url":28,"identifiers":5213},"Grune, T. (, 2006). HNE-modified proteins: Formation, distribution and fate. Proceedings of the 3rd International Meeting of the HNE-Club, Genova, Italy. Abstract No. 17.",{},{"id":28,"text":5215,"url":28,"identifiers":5216},"Carbone, 2004, 4-hydroxynonenal regulates 26S proteasomal degradation of alcohol dehydrogenase, Free Radic. Biol. Med., 37, 1430, 10.1016\u002Fj.freeradbiomed.2004.07.016",{"doi":5217},"10.1016\u002Fj.freeradbiomed.2004.07.016",{"id":28,"text":5219,"url":28,"identifiers":5220},"Okada, 1999, 4-hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress—Identification of proteasomes as target molecules, J. Biol. Chem., 274, 23787, 10.1074\u002Fjbc.274.34.23787",{"doi":5221},"10.1074\u002Fjbc.274.34.23787",{"id":28,"text":5223,"url":28,"identifiers":5224},"Hyun, 2002, Proteasomal dysfunction induced by 4-hydroxy-2,3-trans-nonenal, an end-product of lipid peroxidation: A mechanism contributing to neurodegeneration?, J. Neurochem., 83, 360, 10.1046\u002Fj.1471-4159.2002.01125.x",{"doi":5225},"10.1046\u002Fj.1471-4159.2002.01125.x",{"id":28,"text":5227,"url":28,"identifiers":5228},"Li, 2005, The effect of ethanol-induced CYP2E1 on proteasome activity: The role of 4-hydroxynonenal, Exp. Mol. Pathol., 78, 109, 10.1016\u002Fj.yexmp.2004.10.005",{"doi":5229},"10.1016\u002Fj.yexmp.2004.10.005",{"id":28,"text":5231,"url":28,"identifiers":5232},"Kessova, 2005, The effect of CYP2E1-dependent oxidant stress on activity of proteasomes in HepG2 cells, J. Pharmacol. Exp. Ther., 315, 304, 10.1124\u002Fjpet.105.088047",{"doi":5233},"10.1124\u002Fjpet.105.088047",{"id":28,"text":5235,"url":28,"identifiers":5236},"Ferrington, 2004, Catalytic site-specific inhibition of the 20S proteasome by 4-hydroxynonenal, FEBS Lett., 578, 217, 10.1016\u002Fj.febslet.2004.11.003",{"doi":5237},"10.1016\u002Fj.febslet.2004.11.003",{"id":28,"text":5239,"url":28,"identifiers":5240},"Tsuchiya, 2005, Degradation of glyceraldehyde-3-phosphate dehydrogenase triggered by 4-hydroxy-2-nonenal and 4-hydroxy-2-hexenal, Arch. Biochem. Biophys., 438, 217, 10.1016\u002Fj.abb.2005.04.015",{"doi":5241},"10.1016\u002Fj.abb.2005.04.015",{"id":28,"text":5243,"url":28,"identifiers":5244},"Xu, 1999, Independent synthesis, solution behavior, and studies on the mechanism of formation of a primary amine-derived fluorophore representing cross-linking of proteins by (E)-4-hydroxy-2-nonenal, J. Org. Chem., 64, 5732, 10.1021\u002Fjo982523j",{"doi":5245},"10.1021\u002Fjo982523j",{"id":28,"text":5247,"url":28,"identifiers":5248},"Zarkovic, 2009, Protein-aldehydic adducts as biomarkers of oxidative stress, lipid peroxidation and oxidative homeostasis, Free Radic. Res., 43, 33",{},{"id":28,"text":5250,"url":28,"identifiers":5251},"Wang, 2013, Oxidative protein modification of soluble N-ethylmaleimide-sensitive factor attachment protein receptors, FASEB J., 27, 890",{},{"id":28,"text":5253,"url":28,"identifiers":5254},"Gallagher, 2006, Several glutathione S-transferase isozymes that protect against oxidative injury are expressed in human liver mitochondria, Biochem. Pharmacol., 71, 1619, 10.1016\u002Fj.bcp.2006.02.018",{"doi":5255},"10.1016\u002Fj.bcp.2006.02.018",{"id":28,"text":5257,"url":28,"identifiers":5258},"Alary, 2003, Identification of intermediate pathways of 4-hydroxynonenal metabolism in the rat, Chem. Res.Toxicol., 16, 320, 10.1021\u002Ftx025671k",{"doi":5259},"10.1021\u002Ftx025671k",{"id":28,"text":5261,"url":28,"identifiers":5262},"Lucas, 2002, Effect of glutathione augmentation on lipid peroxidation after spinal cord injury, J. Neurotrauma, 19, 763, 10.1089\u002F08977150260139138",{"doi":5263},"10.1089\u002F08977150260139138",{"id":28,"text":5265,"url":28,"identifiers":5266},"Yang, 2003, Lipid peroxidation and cell cycle signaling: 4-Hydroxynonenal, a key molecule in stress mediated signaling, Acta Biochim. Polonica, 50, 319, 10.18388\u002Fabp.2003_3689",{"doi":5267},"10.18388\u002Fabp.2003_3689",{"id":28,"text":5269,"url":28,"identifiers":5270},"Patrick, 2005, Depletion of 4-hydroxynonenal in hGSTA4-transfected HLE B-3 cells results in profound changes in gene expression, Biochem. Biophys. Res. Commun., 334, 425, 10.1016\u002Fj.bbrc.2005.06.099",{"doi":5271},"10.1016\u002Fj.bbrc.2005.06.099",{"id":28,"text":5273,"url":28,"identifiers":5274},"Dwivedi, 2006, The course of CCl4 induced hepatotoxicity is altered in mGSTA4-4 null (−\u002F−) mice, Toxicology, 218, 58, 10.1016\u002Fj.tox.2005.10.012",{"doi":5275},"10.1016\u002Fj.tox.2005.10.012",{"id":28,"text":5277,"url":28,"identifiers":5278},"Engle, 2004, Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: Generation and analysis of mGSTA4 null mouse, Toxicol. Appl. Pharmacol., 194, 296, 10.1016\u002Fj.taap.2003.10.001",{"doi":5279},"10.1016\u002Fj.taap.2003.10.001",{"id":28,"text":5281,"url":28,"identifiers":5282},"Knoll, 2005, Genotoxicity of 4-hydroxy-2-nonenal in human colon tumor cells is associated with cellular levels of glutathione and the modulation of glutathione S-transferase A4 expression by butyrate, Toxicol. Sci., 86, 27, 10.1093\u002Ftoxsci\u002Fkfi171",{"doi":5283},"10.1093\u002Ftoxsci\u002Fkfi171",{"id":28,"text":5285,"url":28,"identifiers":5286},"Srivastava, 2010, Synthesis, quantification, characterization, and signaling properties of glutathionyl conjugates of enals, Methods Enzymol., 474, 297, 10.1016\u002FS0076-6879(10)74018-0",{"doi":5287},"10.1016\u002FS0076-6879(10)74018-0",{"id":28,"text":5289,"url":28,"identifiers":5290},"Frohnert, 2014, Glutathionylated lipid aldehydes are products of adipocyte oxidative stress and activators of macrophage inflammation, Diabetes, 63, 89, 10.2337\u002Fdb13-0777",{"doi":5291},"10.2337\u002Fdb13-0777",{"id":28,"text":5293,"url":28,"identifiers":5294},"Spite, 2009, Resolvin D1 controls inflammation initiated by glutathione-lipid conjugates formed during oxidative stress, Br. J. Pharmacol., 158, 1062, 10.1111\u002Fj.1476-5381.2009.00234.x",{"doi":5295},"10.1111\u002Fj.1476-5381.2009.00234.x",{"id":28,"text":5297,"url":28,"identifiers":5298},"Aldini, 2005, Carnosine and related dipeptides as quenchers of reactive carbonyl species: From structural studies to therapeutic perspectives, Biofactors, 24, 77, 10.1002\u002Fbiof.5520240109",{"doi":5299},"10.1002\u002Fbiof.5520240109",{"id":28,"text":5301,"url":28,"identifiers":5302},"Aldini, 2002, Carnosine is a quencher of 4-hydroxy-nonenal: Through what mechanism of reaction?, Biochem. Biophys. Res. Commun., 298, 699, 10.1016\u002FS0006-291X(02)02545-7",{"doi":5303},"10.1016\u002FS0006-291X(02)02545-7",{"id":28,"text":5305,"url":28,"identifiers":5306},"Barski, 2013, Dietary carnosine prevents early atherosclerotic lesion formation in apolipoprotein e-null mice, Arterioscler. Thromb. Vasc. Biol., 33, 1162, 10.1161\u002FATVBAHA.112.300572",{"doi":5307},"10.1161\u002FATVBAHA.112.300572",{"id":28,"text":5309,"url":28,"identifiers":5310},"Wang, 2012, Shotgun lipidomics analysis of 4-hydroxyalkenal species directly from lipid extracts after one-step in situ derivatization, Anal. Chem., 84, 4580, 10.1021\u002Fac300695p",{"doi":5311},"10.1021\u002Fac300695p",{"id":28,"text":5313,"url":28,"identifiers":5314},"Guiotto, 2005, Synthesis and evaluation of neuroprotective alpha,beta-unsaturated aldehyde scavenger histidyl-containing analogues of carnosine, J. Med. Chem., 48, 6156, 10.1021\u002Fjm050507q",{"doi":5315},"10.1021\u002Fjm050507q",{"id":28,"text":5317,"url":28,"identifiers":5318},"Guiotto, 2005, Carnosine and carnosine-related antioxidants: A review, Curr. Med. Chem., 12, 2293, 10.2174\u002F0929867054864796",{"doi":5319},"10.2174\u002F0929867054864796",{"id":28,"text":5321,"url":28,"identifiers":5322},"Vistoli, 2009, Design, synthesis, and evaluation of carnosine derivatives as selective and efficient sequestering agents of cytotoxic reactive carbonyl species, Chemmedchem, 4, 967, 10.1002\u002Fcmdc.200800433",{"doi":5323},"10.1002\u002Fcmdc.200800433",{"id":28,"text":5325,"url":28,"identifiers":5326},"Bertinaria, 2011, Synthesis, physicochemical characterization, and biological activities of new carnosine derivatives stable in human serum as potential neuroprotective agents, J. Med. Chem., 54, 611, 10.1021\u002Fjm101394n",{"doi":5327},"10.1021\u002Fjm101394n",{"id":28,"text":5329,"url":28,"identifiers":5330},"Sugano, 2013, Different anti-oxidant effects of thioredoxin 1 and thioredoxin 2 in retinal epithelial cells, Cell Struct. Funct., 38, 81, 10.1247\u002Fcsf.12025",{"doi":5331},"10.1247\u002Fcsf.12025",{"id":28,"text":5333,"url":28,"identifiers":5334},"Zhang, 2014, Glutaredoxin 2 reduces both thioredoxin 2 and thioredoxin 1 and protects cells from apoptosis induced by auranofin and 4-hydroxynonenal, Antioxid. Redox Signal., 21, 669, 10.1089\u002Fars.2013.5499",{"doi":5335},"10.1089\u002Fars.2013.5499",{"id":28,"text":5337,"url":28,"identifiers":5338},"Tang, 2011, A mass spectrometric analysis of 4-hydroxy-2-(E)-nonenal modification of cytochrome c, J. Mass Spectrom., 46, 290, 10.1002\u002Fjms.1890",{"doi":5339},"10.1002\u002Fjms.1890",{"id":28,"text":5341,"url":28,"identifiers":5342},"Gardner, 2001, Effect of 4-hydroxy-2(E)-nonenal on soybean lipoxygenase-1, Lipids, 36, 623, 10.1007\u002Fs11745-001-0766-9",{"doi":5343},"10.1007\u002Fs11745-001-0766-9",{"id":28,"text":5345,"url":28,"identifiers":5346},"Uchida, 1993, Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase—A possible involvement of intramolecular and intermolecular cross-linking reaction, J. Biol. Chem., 268, 6388, 10.1016\u002FS0021-9258(18)53264-6",{"doi":5347},"10.1016\u002FS0021-9258(18)53264-6",{"id":28,"text":5349,"url":28,"identifiers":5350},"Ishii, 2003, Molecular basis of enzyme inactivation by an endogenous electrophile 4-hydroxy-2-nonenal: Identification of modification sites in glyceraldehyde-3-phosphate dehydrogenase, Biochemistry, 42, 3474, 10.1021\u002Fbi027172o",{"doi":5351},"10.1021\u002Fbi027172o",{"id":28,"text":5353,"url":28,"identifiers":5354},"Ploemen, 1997, Interactions of α,β-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1, Chem. Biol. Interact., 108, 67, 10.1016\u002FS0009-2797(97)00096-3",{"doi":5355},"10.1016\u002FS0009-2797(97)00096-3",{"id":28,"text":5357,"url":28,"identifiers":5358},"Flohe, 1999, 4-Hydroxynonenal inhibits glutathione peroxidase: Protection by glutathione, Free Radic. Biol. Med., 26, 1383, 10.1016\u002FS0891-5849(98)00335-9",{"doi":5359},"10.1016\u002FS0891-5849(98)00335-9",{"id":28,"text":5361,"url":28,"identifiers":5362},"Korotchkina, 2001, Protection by thiols of the mitochondrial complexes from 4-hydroxy-2-nonenal, Free Radic. Biol. Med., 30, 992, 10.1016\u002FS0891-5849(01)00491-9",{"doi":5363},"10.1016\u002FS0891-5849(01)00491-9",{"id":28,"text":5365,"url":28,"identifiers":5366},"Vilardo, 1998, Site-specific inactivation of aldose reductase by 4-hydroxynonenal, Arch. Biochem. Biophys., 350, 245, 10.1006\u002Fabbi.1997.0488",{"doi":5367},"10.1006\u002Fabbi.1997.0488",{"id":28,"text":5369,"url":28,"identifiers":5370},"Yu, 2004, Conditional expression of 15-lipoxygenase-1 inhibits the selenoenzyme thioredoxin reductase—Modulation of selenoproteins by lipoxygenase enzymes, J. Biol. Chem., 279, 28028, 10.1074\u002Fjbc.M313939200",{"doi":5371},"10.1074\u002Fjbc.M313939200",{"id":28,"text":5373,"url":28,"identifiers":5374},"Fang, 2006, Inhibition of thioredoxin and thioredoxin reductase by 4-hydroxy-2-nonenal in vitro and in vivo, J. Am. Chem. Soc., 128, 1879, 10.1021\u002Fja057358l",{"doi":5375},"10.1021\u002Fja057358l",{"id":28,"text":5377,"url":28,"identifiers":5378},"Chen, 2005, 4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2, J. Biol. Chem., 280, 41921, 10.1074\u002Fjbc.M508556200",{"doi":5379},"10.1074\u002Fjbc.M508556200",{"id":28,"text":5381,"url":28,"identifiers":5382},"Chen, 2006, Adaptive response induced by lipid peroxidation products in cell cultures, FEBS Lett., 580, 479, 10.1016\u002Fj.febslet.2005.12.045",{"doi":5383},"10.1016\u002Fj.febslet.2005.12.045",{"id":28,"text":5385,"url":28,"identifiers":5386},"Morquette, 2006, Production of lipid peroxidation products in osteoarthritic tissues—New evidence linking 4-hydroxynonenal to cartilage degradation, Arthritis Rheum., 54, 271, 10.1002\u002Fart.21559",{"doi":5387},"10.1002\u002Fart.21559",{"id":28,"text":5389,"url":28,"identifiers":5390},"Ramanathan, 2014, Covalent binding of 4-hydroxy-2-nonenal to lactate dehydrogenase decreases NADH formation and metmyoglobin reducing activity, J. Agric. Food Chem., 62, 2112, 10.1021\u002Fjf404900y",{"doi":5391},"10.1021\u002Fjf404900y",{"id":28,"text":5393,"url":28,"identifiers":5394},"Schlisser, 2010, Teratogen-induced oxidative stress targets glyceraldehyde-3-phosphate dehydrogenase in the organogenesis stage mouse embryo, Toxicol. Sci., 118, 686, 10.1093\u002Ftoxsci\u002Fkfq287",{"doi":5395},"10.1093\u002Ftoxsci\u002Fkfq287",{"id":28,"text":5397,"url":28,"identifiers":5398},"Markesbery, 1999, Oxidative alterations in Alzheimer’s disease, Brain Pathol., 9, 133, 10.1111\u002Fj.1750-3639.1999.tb00215.x",{"doi":5399},"10.1111\u002Fj.1750-3639.1999.tb00215.x",{"id":28,"text":5401,"url":28,"identifiers":5402},"Butterfield, 2002, Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: Potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress1,2, Free Radic. Biol. Med., 32, 1050, 10.1016\u002FS0891-5849(02)00794-3",{"doi":5403},"10.1016\u002FS0891-5849(02)00794-3",{"id":28,"text":5405,"url":28,"identifiers":5406},"Markesbery, 1998, Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer’s disease, Neurobiol. Aging, 19, 33, 10.1016\u002FS0197-4580(98)00009-8",{"doi":5407},"10.1016\u002FS0197-4580(98)00009-8",{"id":28,"text":5409,"url":28,"identifiers":5410},"Sultana, 2004, Oxidatively modified GST and MRP1 in Alzheimer’s disease brain: Implications for accumulation of reactive lipid peroxidation products, Neurochem. Res., 29, 2215, 10.1007\u002Fs11064-004-7028-0",{"doi":5411},"10.1007\u002Fs11064-004-7028-0",{"id":28,"text":5413,"url":28,"identifiers":5414},"Huang, 2012, Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal, Cell Biosci., 2, 1, 10.1186\u002F2045-3701-2-40",{"doi":5415},"10.1186\u002F2045-3701-2-40",{"id":28,"text":5417,"url":28,"identifiers":5418},"Balogh, 2010, Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal, Biochemistry, 49, 1541, 10.1021\u002Fbi902038u",{"doi":5419},"10.1021\u002Fbi902038u",{"id":28,"text":5421,"url":28,"identifiers":5422},"Calamaras, 2012, Post-translational modification of serine\u002Fthreonine kinase LKB1 via adduction of the reactive lipid species 4-hydroxy-trans-2-nonenal (HNE) at lysine residue 97 directly inhibits kinase activity, J. Biol. Chem., 287, 42400, 10.1074\u002Fjbc.M112.385831",{"doi":5423},"10.1074\u002Fjbc.M112.385831",{"id":28,"text":5425,"url":28,"identifiers":5426},"Shearn, 2014, Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol, J. Biol. Chem., 289, 15449, 10.1074\u002Fjbc.M113.543942",{"doi":5427},"10.1074\u002Fjbc.M113.543942",{"id":28,"text":5429,"url":28,"identifiers":5430},"Wang, 2014, A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles, Nat. Methods, 11, 79, 10.1038\u002Fnmeth.2759",{"doi":5431},"10.1038\u002Fnmeth.2759",{"id":28,"text":5433,"url":28,"identifiers":5434},"Shearn, 2011, Modification of Akt2 by 4-hydroxynonenal inhibits insulin-dependent Akt signaling in HepG2 cells, Biochemistry, 50, 3984, 10.1021\u002Fbi200029w",{"doi":5435},"10.1021\u002Fbi200029w",{"id":28,"text":5437,"url":28,"identifiers":5438},"MacDonald, 2013, Identification of ATP synthase as a lipid peroxide protein adduct in pancreatic islets from humans with and without type 2 Diabetes mellitus, J. Clin. Endocrinol. Metab., 98, E727, 10.1210\u002Fjc.2012-4203",{"doi":5439},"10.1210\u002Fjc.2012-4203",{"id":28,"text":5441,"url":28,"identifiers":5442},"Guo, 2011, Protein targets for carbonylation by 4-hydroxy-2-nonenal in rat liver mitochondria, J. Proteomics, 74, 2370, 10.1016\u002Fj.jprot.2011.07.009",{"doi":5443},"10.1016\u002Fj.jprot.2011.07.009",{"id":28,"text":5445,"url":28,"identifiers":5446},"Shearn, 2011, Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes, Mol. Pharmacol., 79, 941, 10.1124\u002Fmol.110.069534",{"doi":5447},"10.1124\u002Fmol.110.069534",{"id":28,"text":5449,"url":28,"identifiers":5450},"Fang, 2013, Temporally controlled targeting of 4-hydroxynonenal to specific proteins in living cells, J. Am. Chem. Soc., 135, 14496, 10.1021\u002Fja405400k",{"doi":5451},"10.1021\u002Fja405400k",{"id":28,"text":5453,"url":28,"identifiers":5454},"Los, 2008, HatoTag: A novel protein labeling technology for cell imaging and protein analysis, ACS Chem. Biol., 3, 373, 10.1021\u002Fcb800025k",{"doi":5455},"10.1021\u002Fcb800025k",{"id":28,"text":5457,"url":28,"identifiers":5458},"Fritz, 2011, 4-hydroxynonenal inhibits SIRT3 via thiol-specific modification, Chem. Res. Toxicol., 24, 651, 10.1021\u002Ftx100355a",{"doi":5459},"10.1021\u002Ftx100355a",{"id":28,"text":5461,"url":28,"identifiers":5462},"Krohne, 2010, Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action, Exp. Eye Res., 90, 261, 10.1016\u002Fj.exer.2009.10.014",{"doi":5463},"10.1016\u002Fj.exer.2009.10.014",{"id":28,"text":5465,"url":28,"identifiers":5466},"Wang, 2003, Oxidized neprilysin in aging and Alzheimer’s disease brains, Biochem. Biophys. Res. Commun., 310, 236, 10.1016\u002Fj.bbrc.2003.09.003",{"doi":5467},"10.1016\u002Fj.bbrc.2003.09.003",{"id":28,"text":5469,"url":28,"identifiers":5470},"Wang, 2009, Effects of HNE-modification induced by A beta on neprilysin expression and activity in SH-SY5Y cells, J. Neurochem., 108, 1072, 10.1111\u002Fj.1471-4159.2008.05855.x",{"doi":5471},"10.1111\u002Fj.1471-4159.2008.05855.x",{"id":28,"text":5473,"url":28,"identifiers":5474},"Wang, 2010, N-Acetylcysteine prevents 4-hydroxynonenal—And amyloid-β-induced modification and inactivation of neprilysin in SH-SY5Y cells, J. Alzheimers Dis., 19, 179, 10.3233\u002FJAD-2010-1226",{"doi":5475},"10.3233\u002FJAD-2010-1226",{"id":28,"text":5477,"url":28,"identifiers":5478},"Liu, 2013, Carbonylation of mitochondrial aconitase with 4-hydroxy-2-(E)-nonenal: Localization and relative reactivity of addition sites, Biochim. Biophys. Acta Proteins Proteomics, 1834, 1144, 10.1016\u002Fj.bbapap.2013.03.005",{"doi":5479},"10.1016\u002Fj.bbapap.2013.03.005",{"id":28,"text":5481,"url":28,"identifiers":5482},"Zhao, 2014, Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment, Free Radic. Biol. Med., 72, 55, 10.1016\u002Fj.freeradbiomed.2014.03.001",{"doi":5483},"10.1016\u002Fj.freeradbiomed.2014.03.001",{"id":28,"text":5485,"url":28,"identifiers":5486},"Gentile, 2009, Exposure of HL-60 human leukaemic cells to 4-hydroxynonenal promotes the formation of adduct(s) with alpha-enolase devoid of plasminogen binding activity, Biochem. J., 422, 285, 10.1042\u002FBJ20090564",{"doi":5487},"10.1042\u002FBJ20090564",{"id":28,"text":5489,"url":28,"identifiers":5490},"Reed, 2009, Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD, Brain Res., 1274, 66, 10.1016\u002Fj.brainres.2009.04.009",{"doi":5491},"10.1016\u002Fj.brainres.2009.04.009",{"id":28,"text":5493,"url":28,"identifiers":5494},"Muller, 2013, Protein disulfide isomerase modification and inhibition contribute to ER stress and apoptosis induced by oxidized low density lipoproteins, Antioxid. Redox Signal., 18, 731, 10.1089\u002Fars.2012.4577",{"doi":5495},"10.1089\u002Fars.2012.4577",{"id":28,"text":5497,"url":28,"identifiers":5498},"Aluise, 2013, Peptidyl-prolyl cis\u002Ftrans-isomerase A1 (Pin1) is a target for modification by lipid electrophiles, Chem. Res. Toxicol., 26, 270, 10.1021\u002Ftx300449g",{"doi":5499},"10.1021\u002Ftx300449g",{"id":28,"text":5501,"url":28,"identifiers":5502},"Tanito, 2006, Identification of 4-hydroxynonenal-modified retinal proteins induced by photooxidative stress prior to retinal degeneration, Free Radic. Biol. Med., 41, 1847, 10.1016\u002Fj.freeradbiomed.2006.09.012",{"doi":5503},"10.1016\u002Fj.freeradbiomed.2006.09.012",{"id":28,"text":5505,"url":28,"identifiers":5506},"Toyokuni, 2000, Serum 4-hydroxy-2-nonenal-modified albumin is elevated in patients with type 2 Diabetes Mellitus, Antioxid. Redox Signal., 2, 681, 10.1089\u002Fars.2000.2.4-681",{"doi":5507},"10.1089\u002Fars.2000.2.4-681",{"id":28,"text":5509,"url":28,"identifiers":5510},"Aldini, 2006, Mass spectrometric characterization of covalent modification of human serum albumin by 4-hydroxy-trans-2-nonenal, J. Mass Spectrom., 41, 1149, 10.1002\u002Fjms.1067",{"doi":5511},"10.1002\u002Fjms.1067",{"id":28,"text":5513,"url":28,"identifiers":5514},"Liu, 2012, The reactivity of human serum albumin towards trans-4-hydroxy-2-nonenal, J. Mass Spectrom., 47, 411, 10.1002\u002Fjms.2037",{"doi":5515},"10.1002\u002Fjms.2037",{"id":28,"text":5517,"url":28,"identifiers":5518},"Khatoon, 2012, Physicochemical and immunological studies on 4-hydroxynonenal modified HSA: Implications of protein damage by lipid peroxidation products in the etiopathogenesis of SLE, Hum. Immunol., 73, 1132, 10.1016\u002Fj.humimm.2012.08.011",{"doi":5519},"10.1016\u002Fj.humimm.2012.08.011",{"id":28,"text":5521,"url":28,"identifiers":5522},"Xiang, 2013, Oxidative stress-induced posttranslational modifications of human hemoglobin in erythrocytes, Arch. Biochem. Biophys., 529, 34, 10.1016\u002Fj.abb.2012.11.002",{"doi":5523},"10.1016\u002Fj.abb.2012.11.002",{"id":28,"text":5525,"url":28,"identifiers":5526},"Naveena, 2010, Detection of 4-hydroxy-2-nonenal adducts of turkey and chicken myoglobins using mass spectrometry, Food Chem., 122, 836, 10.1016\u002Fj.foodchem.2010.02.062",{"doi":5527},"10.1016\u002Fj.foodchem.2010.02.062",{"id":28,"text":5529,"url":28,"identifiers":5530},"Smathers, 2012, Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics, PLoS ONE, 7, e38459, 10.1371\u002Fjournal.pone.0038459",{"doi":5531},"10.1371\u002Fjournal.pone.0038459",{"id":28,"text":5533,"url":28,"identifiers":5534},"Hellberg, 2010, X-ray crystallographic analysis of adipocyte fatty acid binding protein (aP2) modified with 4-hydroxy-2-nonenal, Protein Sci., 19, 1480, 10.1002\u002Fpro.427",{"doi":5535},"10.1002\u002Fpro.427",{"id":28,"text":5537,"url":28,"identifiers":5538},"Stewart, 2009, Lipid aldehyde-mediated cross-linking of apolipoprotein B-100 inhibits secretion from HepG2 cells, Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1791, 772, 10.1016\u002Fj.bbalip.2009.04.004",{"doi":5539},"10.1016\u002Fj.bbalip.2009.04.004",{"id":28,"text":5541,"url":28,"identifiers":5542},"Shao, 2010, Modifying apolipoprotein A–I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway, J. Biol. Chem., 285, 18473, 10.1074\u002Fjbc.M110.118182",{"doi":5543},"10.1074\u002Fjbc.M110.118182",{"id":28,"text":5545,"url":28,"identifiers":5546},"Zhu, 2009, Mass spectrometric characterization of protein modification by the products of nonenzymatic oxidation of linoleic acid, Chem. Res. Toxicol., 22, 1386, 10.1021\u002Ftx9000072",{"doi":5547},"10.1021\u002Ftx9000072",{"id":28,"text":5549,"url":28,"identifiers":5550},"Ou, 2002, In vivo assessment of lipid peroxidation products associated with age-related neurodegenerative diseases, Exp. Neurol., 175, 363, 10.1006\u002Fexnr.2002.7923",{"doi":5551},"10.1006\u002Fexnr.2002.7923",{"id":28,"text":5553,"url":28,"identifiers":5554},"Mattson, 2003, Neuronal and glial calcium signaling in Alzheimer’s disease, Cell Calcium, 34, 385, 10.1016\u002FS0143-4160(03)00128-3",{"doi":5555},"10.1016\u002FS0143-4160(03)00128-3",{"id":28,"text":5557,"url":28,"identifiers":5558},"Pedersen, 1998, Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients, Ann. Neurol., 44, 819, 10.1002\u002Fana.410440518",{"doi":5559},"10.1002\u002Fana.410440518",{"id":28,"text":5561,"url":28,"identifiers":5562},"Lovell, 2012, 4-Hydroxyhexenal (HHE) impairs glutamate transport in astrocyte cultures, J. Alzheimers Dis., 32, 139, 10.3233\u002FJAD-2012-120409",{"doi":5563},"10.3233\u002FJAD-2012-120409",{"id":28,"text":5565,"url":28,"identifiers":5566},"Maroteaux, 1988, Synuclein: A neuron-specific protein localized to the nucleus and presynaptic nerve terminal, J. Neurosci., 8, 2804, 10.1523\u002FJNEUROSCI.08-08-02804.1988",{"doi":5567},"10.1523\u002FJNEUROSCI.08-08-02804.1988",{"id":28,"text":5569,"url":28,"identifiers":5570},"Cabin, 2002, Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein, J. Neurosci., 22, 8797, 10.1523\u002FJNEUROSCI.22-20-08797.2002",{"doi":5571},"10.1523\u002FJNEUROSCI.22-20-08797.2002",{"id":28,"text":5573,"url":28,"identifiers":5574},"Murphy, 2000, Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons, J. Neurosci., 20, 3214, 10.1523\u002FJNEUROSCI.20-09-03214.2000",{"doi":5575},"10.1523\u002FJNEUROSCI.20-09-03214.2000",{"id":28,"text":5577,"url":28,"identifiers":5578},"Lotharius, 2002, Impaired dopamine storage resulting from α-synuclein mutations may contribute to the pathogenesis of Parkinson’s disease, Hum. Mol. Genet., 11, 2395, 10.1093\u002Fhmg\u002F11.20.2395",{"doi":5579},"10.1093\u002Fhmg\u002F11.20.2395",{"id":28,"text":5581,"url":28,"identifiers":5582},"Jomova, 2010, Metals, oxidative stress and neurodegenerative disorders, Mol. Cell. Biochem., 345, 91, 10.1007\u002Fs11010-010-0563-x",{"doi":5583},"10.1007\u002Fs11010-010-0563-x",{"id":28,"text":5585,"url":28,"identifiers":5586},"Xiang, 2013, Oxidative stress-induced posttranslational modifications of alpha-synuclein: Specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity, Mol. Cell. Neurosci., 54, 71, 10.1016\u002Fj.mcn.2013.01.004",{"doi":5587},"10.1016\u002Fj.mcn.2013.01.004",{"id":28,"text":5589,"url":28,"identifiers":5590},"Bae, 2013, Lipid peroxidation product 4-hydroxy-2-nonenal promotes seeding-capable oligomer formation and cell-to-cell transfer of a-synuclein, Antioxid. Redox Signal., 18, 770, 10.1089\u002Fars.2011.4429",{"doi":5591},"10.1089\u002Fars.2011.4429",{"id":28,"text":5593,"url":28,"identifiers":5594},"Nasstrom, 2011, The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties, Free Radic. Biol. Med., 50, 428, 10.1016\u002Fj.freeradbiomed.2010.11.027",{"doi":5595},"10.1016\u002Fj.freeradbiomed.2010.11.027",{"id":28,"text":5597,"url":28,"identifiers":5598},"Shibata, 2010, Involvement of 4-hydroxy-2-nonenal accumulation in multiple system atrophy, Acta Histochem. Cytochem., 43, 69, 10.1267\u002Fahc.10005",{"doi":5599},"10.1267\u002Fahc.10005",{"id":28,"text":5601,"url":28,"identifiers":5602},"Chardonnet, 2011, Inhibition by 4-hydroxynonenal (HNE) of Ca2+ transport by SERCA1a: Low concentrations of HNE open protein-mediated leaks in the membrane, Free Radic. Biol. Med., 50, 323, 10.1016\u002Fj.freeradbiomed.2010.11.017",{"doi":5603},"10.1016\u002Fj.freeradbiomed.2010.11.017",{"id":28,"text":5605,"url":28,"identifiers":5606},"Gunthorpe, 2002, The diversity in the vanilloid (TRPV) receptor family of ion channels, Trends Pharmacol. Sci., 23, 183, 10.1016\u002FS0165-6147(02)01999-5",{"doi":5607},"10.1016\u002FS0165-6147(02)01999-5",{"id":28,"text":5609,"url":28,"identifiers":5610},"Kishimoto, 2011, Oxidative stress-induced posttranslational modification of TRPV1 expressed in esophageal epithelial cells, Am. J. Physiol. Gastrointest. Liver Physiol., 301, G230, 10.1152\u002Fajpgi.00436.2009",{"doi":5611},"10.1152\u002Fajpgi.00436.2009",{"id":28,"text":5613,"url":28,"identifiers":5614},"Vindis, 2006, Desensitization of platelet-derived growth factor receptor-beta by oxidized lipids in vascular cells and atherosclerotic lesions—Prevention by Aldehyde Scavengers, Circ. Res., 98, 785, 10.1161\u002F01.RES.0000216288.93234.c3",{"doi":5615},"10.1161\u002F01.RES.0000216288.93234.c3",{"id":28,"text":5617,"url":28,"identifiers":5618},"Shimozu, 2012, Identification of 4-hydroxy-2-nonenal-histidine adducts that serve as ligands for human lectin-like oxidized LDL receptor-1, Biochem. J., 442, 171, 10.1042\u002FBJ20111029",{"doi":5619},"10.1042\u002FBJ20111029",{"id":28,"text":5621,"url":28,"identifiers":5622},"Kim, 2009, Alteration of Toll-like receptor 4 activation by 4-hydroxy-2-nonenal mediated by the suppression of receptor homodimerization, Chem. Biol. Interact., 182, 59, 10.1016\u002Fj.cbi.2009.07.009",{"doi":5623},"10.1016\u002Fj.cbi.2009.07.009",{"id":28,"text":5625,"url":28,"identifiers":5626},"Liu, 2005, Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations, Free Radic. Biol. Med., 38, 746, 10.1016\u002Fj.freeradbiomed.2004.11.005",{"doi":5627},"10.1016\u002Fj.freeradbiomed.2004.11.005",{"id":28,"text":5629,"url":28,"identifiers":5630},"Hernandez, 2004, Quinones facilitate the self-assembly of the phosphorylated tubulin binding region of tau into fibrillar polymers, Biochemistry, 43, 2888, 10.1021\u002Fbi035345j",{"doi":5631},"10.1021\u002Fbi035345j",{"id":28,"text":5633,"url":28,"identifiers":5634},"Mendez, 2012, Differential carbonylation of cytoskeletal proteins in blood group O erythrocytes: Potential role in protection against severe malaria, Infect. Genet. Evol., 12, 1780, 10.1016\u002Fj.meegid.2012.06.013",{"doi":5635},"10.1016\u002Fj.meegid.2012.06.013",{"id":28,"text":5637,"url":28,"identifiers":5638},"Arashiki, 2010, The covalent modification of spectrin in red cell membranes by the lipid peroxidation product 4-hydroxy-2-nonenal, Biochem. Biophys. Res. Commun., 391, 1543, 10.1016\u002Fj.bbrc.2009.12.121",{"doi":5639},"10.1016\u002Fj.bbrc.2009.12.121",{"id":28,"text":5641,"url":28,"identifiers":5642},"Mendez, 2010, Combined proteomic approaches for the identification of specific amino acid residues modified by 4-hydroxy-2-nonenal under physiological conditions, J. Proteome Res., 9, 5770, 10.1021\u002Fpr100555v",{"doi":5643},"10.1021\u002Fpr100555v",{"id":28,"text":5645,"url":28,"identifiers":5646},"Yamashima, 2012, Hsp70.1 and related lysosomal factors for necrotic neuronal death, J. Neurochem., 120, 477, 10.1111\u002Fj.1471-4159.2011.07596.x",{"doi":5647},"10.1111\u002Fj.1471-4159.2011.07596.x",{"id":28,"text":5649,"url":28,"identifiers":5650},"Perluigi, 2005, Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice—A model of familial amyotrophic lateral sclerosis, Free Radic. Biol. Med., 38, 960, 10.1016\u002Fj.freeradbiomed.2004.12.021",{"doi":5651},"10.1016\u002Fj.freeradbiomed.2004.12.021",{"id":28,"text":5653,"url":28,"identifiers":5654},"Sahara, 2010, Calpain-mediated Hsp70.1 cleavage in hippocampal CA1 neuronal death, Biochem. Biophys. Res. Commun., 393, 806, 10.1016\u002Fj.bbrc.2010.02.087",{"doi":5655},"10.1016\u002Fj.bbrc.2010.02.087",{"id":28,"text":5657,"url":28,"identifiers":5658},"Connor, 2011, Protein-selective capture to analyze electrophile adduction of Hsp90 by 4-hydroxynonenal, Chem. Res. Toxicol., 24, 1275, 10.1021\u002Ftx200157t",{"doi":5659},"10.1021\u002Ftx200157t",{"id":28,"text":5661,"url":28,"identifiers":5662},"Smathers, 2011, Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease, Chem. Biol. Interact., 192, 107, 10.1016\u002Fj.cbi.2011.02.021",{"doi":5663},"10.1016\u002Fj.cbi.2011.02.021",{"id":28,"text":5665,"url":28,"identifiers":5666},"Jacobs, 2010, Systems analysis of protein modification and cellular responses induced by electrophile stress, Acc. Chem. Res., 43, 673, 10.1021\u002Far900286y",{"doi":5667},"10.1021\u002Far900286y",{"id":28,"text":5669,"url":28,"identifiers":5670},"Galligan, 2014, Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: Functional independence of ATPase activity and chaperone function, Free Radic. Biol. Med., 73, 411, 10.1016\u002Fj.freeradbiomed.2014.06.002",{"doi":5671},"10.1016\u002Fj.freeradbiomed.2014.06.002",{"id":28,"text":5673,"url":28,"identifiers":5674},"Brand, M.D., Buckingham, J.A., Esteves, T.C., Green, K., Lambert, A.J., Miwa, S., Murphy, M.P., Pakay, J.L., Talbot, D.A., and Echtay, K.S. (2004). Mitochondrial superoxide and aging: Uncoupling-protein activity and superoxide production. Free Radic., 203–213.",{"doi":5675},"10.1042\u002Fbss0710203",{"id":28,"text":5677,"url":28,"identifiers":5678},"Esteves, 2005, The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3, Biochim. Biophys. Acta Bioenerget., 1709, 35, 10.1016\u002Fj.bbabio.2005.06.002",{"doi":5679},"10.1016\u002Fj.bbabio.2005.06.002",{"id":28,"text":5681,"url":28,"identifiers":5682},"Smith, 2004, Activation and function of mitochondrial uncoupling protein in plants, J. Biol. Chem., 279, 51944, 10.1074\u002Fjbc.M408920200",{"doi":5683},"10.1074\u002Fjbc.M408920200",{"id":28,"text":3089,"url":28,"identifiers":5685},{"doi":3091},{"id":28,"text":5687,"url":28,"identifiers":5688},"Echtay, 2005, Hydroxynonenal and uncoupling proteins: A model for protection against oxidative damage, Biofactors, 24, 119, 10.1002\u002Fbiof.5520240114",{"doi":5689},"10.1002\u002Fbiof.5520240114",{"id":28,"text":5691,"url":28,"identifiers":5692},"Malingriaux, 2013, Fatty acids are key in 4-hydroxy-2-nonenal-mediated activation of uncoupling proteins 1 and 2, PLoS ONE, 8, e77786, 10.1371\u002Fjournal.pone.0077786",{"doi":5693},"10.1371\u002Fjournal.pone.0077786",{"id":28,"text":5695,"url":28,"identifiers":5696},"Jarmuszkiewicz, 2013, Hydroxynonenal-stimulated activity of the uncoupling protein in Acanthamoeba castellanii mitochondria under phosphorylating conditions, Biol. Chem., 394, 649, 10.1515\u002Fhsz-2012-0326",{"doi":5697},"10.1515\u002Fhsz-2012-0326",{"id":28,"text":5699,"url":28,"identifiers":5700},"Aguirre, 2010, GDP and carboxyatractylate inhibit 4-hydroxynonenal-activated proton conductance to differing degrees in mitochondria from skeletal muscle and heart, Biochim. Biophys. Acta Bioenerget., 1797, 1716, 10.1016\u002Fj.bbabio.2010.06.009",{"doi":5701},"10.1016\u002Fj.bbabio.2010.06.009",{"id":28,"text":5703,"url":28,"identifiers":5704},"Jin, 2013, Oxidatively modified proteins as plasma biomarkers in breast cancer, Cancer Biomarkers, 13, 193, 10.3233\u002FCBM-130349",{"doi":5705},"10.3233\u002FCBM-130349",{"id":28,"text":5707,"url":28,"identifiers":5708},"Pillon, 2011, Structural and functional changes in human insulin induced by the lipid peroxidation byproducts 4-hydroxy-2-nonenal and 4-hydroxy-2-hexenal, Chem. Res.Toxicol., 24, 752, 10.1021\u002Ftx200084d",{"doi":5709},"10.1021\u002Ftx200084d",{"id":28,"text":5711,"url":28,"identifiers":5712},"Lee, 2010, Mass spectrometric characterization of modifications to angiotensin II by lipid peroxidation products, 4-oxo-2(E)-nonenal and 4-hydroxy-2(E)-nonenal, Chem. Res. Toxicol., 23, 1771, 10.1021\u002Ftx100228q",{"doi":5713},"10.1021\u002Ftx100228q",{"id":28,"text":5715,"url":28,"identifiers":5716},"El-Bikai, R., Welman, M., Margaron, Y., Cote, J.-F., Macqueen, L., Buschmann, M.D., Fahmi, H., Shi, Q., Maghni, K., and Fernandes, J.C. (2010). Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: Implication in osteoarthritis pathogenesis. Arthritis Res. Ther., 12.",{"doi":5717},"10.1186\u002Far3173",{"id":28,"text":5719,"url":28,"identifiers":5720},"Alzolibani, 2013, 4-Hydroxy-2-nonenal modified histone-H2A: A possible antigenic stimulus for systemic lupus erythematosus autoantibodies, Cell. Immunol., 284, 154, 10.1016\u002Fj.cellimm.2013.07.011",{"doi":5721},"10.1016\u002Fj.cellimm.2013.07.011",{"id":28,"text":5723,"url":28,"identifiers":5724},"Guichardant, 1998, Covalent modifications of aminophospholipids by 4-hydroxynonenal, Free Radic. Biol. Med., 25, 1049, 10.1016\u002FS0891-5849(98)00149-X",{"doi":5725},"10.1016\u002FS0891-5849(98)00149-X",{"id":28,"text":5727,"url":28,"identifiers":5728},"Guo, 2012, Identification of novel bioactive aldehyde-modified phosphatidylethanolamines formed by lipid peroxidation, Free Radic. Biol. Med., 53, 1226, 10.1016\u002Fj.freeradbiomed.2012.07.077",{"doi":5729},"10.1016\u002Fj.freeradbiomed.2012.07.077",{"id":28,"text":5731,"url":28,"identifiers":5732},"Sowell, 2004, Vitamin C conjugates of genotoxic lipid peroxidation products: Structural characterization and detection in human plasma, Proc. Natl. Acad. Sci. USA, 101, 17964, 10.1073\u002Fpnas.0408433102",{"doi":5733},"10.1073\u002Fpnas.0408433102",{"id":28,"text":5735,"url":28,"identifiers":5736},"Sowell, 2007, Vitamin C conjugates of genotoxic lipid peroxidation products: Structural characterization and detection in human plasma, Proc. Natl. Acad. Sci. USA, 104, 14543, 10.1073\u002Fpnas.0706514104",{"doi":5737},"10.1073\u002Fpnas.0706514104",{"id":28,"text":5739,"url":28,"identifiers":5740},"Miranda, 2009, Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells, Chem. Res. Toxicol., 22, 863, 10.1021\u002Ftx900042u",{"doi":5741},"10.1021\u002Ftx900042u",{"id":28,"text":5743,"url":28,"identifiers":5744},"Amarnath, 2004, Pyridoxamine: An extremely potent scavenger of 1,4-dicarbonyls, Chem. Res. Toxicol., 17, 410, 10.1021\u002Ftx0300535",{"doi":5745},"10.1021\u002Ftx0300535",{"id":28,"text":5747,"url":28,"identifiers":5748},"Hardas, 2013, Oxidative modification of lipoic acid by HNE in Alzheimer disease brain, Redox Biol., 1, 80, 10.1016\u002Fj.redox.2013.01.002",{"doi":5749},"10.1016\u002Fj.redox.2013.01.002",{"id":28,"text":5751,"url":28,"identifiers":5752},"Voulgaridou, 2011, DNA damage induced by endogenous aldehydes: Current state of knowledge, Mutat. Res. Fund. Mol. Mech. Mutagen., 711, 13, 10.1016\u002Fj.mrfmmm.2011.03.006",{"doi":5753},"10.1016\u002Fj.mrfmmm.2011.03.006",{"id":28,"text":5755,"url":28,"identifiers":5756},"Minko, 2009, Chemistry and biology of DNA containing 1,N2-deoxyguanosine adducts of the α,β-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal, Chem. Res. Toxicol., 22, 759, 10.1021\u002Ftx9000489",{"doi":5757},"10.1021\u002Ftx9000489",{"id":28,"text":5759,"url":28,"identifiers":5760},"Eckl, 1993, Genotoxic properties of 4-hydroxyalkenals and analogous aldehydes, Mutat. Res. Fund. Mol. Mech. Mutagen., 290, 183, 10.1016\u002F0027-5107(93)90158-C",{"doi":3075},{"id":28,"text":5762,"url":28,"identifiers":5763},"Karlhuber, 1997, Cytotoxic and genotoxic effects of 4-hydroxynonenal in cerebral endothelial cells, Mutat. Res. Fund. Mol. Mech. Mutagen., 381, 209, 10.1016\u002FS0027-5107(97)00170-X",{"doi":5764},"10.1016\u002FS0027-5107(97)00170-X",{"id":28,"text":5766,"url":28,"identifiers":5767},"Wang, 2003, Site-specific synthesis and reactivity of oligonucleotides containing stereochemically defined 1,N2-deoxyguanosine adducts of the lipid peroxidation product trans-4-hydroxynonenal, J. Am. Chem. Soc., 125, 5687, 10.1021\u002Fja0288800",{"doi":5768},"10.1021\u002Fja0288800",{"id":28,"text":5770,"url":28,"identifiers":5771},"Wacker, 2001, Detection of 1,N2-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal after gavage of trans-4-hydroxy-2-nonenal or induction of lipid peroxidation with carbon tetrachloride in F344 rats, Chem. Biol. Interact., 137, 269, 10.1016\u002FS0009-2797(01)00259-9",{"doi":5772},"10.1016\u002FS0009-2797(01)00259-9",{"id":28,"text":5774,"url":28,"identifiers":5775},"Kozekov, 2010, Formation of deoxyguanosine cross-links from calf thymus DNA treated with acrolein and 4-hydroxy-2-nonenal, Chem. Res. Toxicol., 23, 1701, 10.1021\u002Ftx100179g",{"doi":5776},"10.1021\u002Ftx100179g",{"id":28,"text":5778,"url":28,"identifiers":5779},"Huang, 2010, DNA Cross-link induced by trans-4-Hydroxynonenal, Environ. Mol. Mutagen., 51, 625, 10.1002\u002Fem.20599",{"doi":5780},"10.1002\u002Fem.20599",{"id":28,"text":5782,"url":28,"identifiers":5783},"Huang, 2011, Formation of a N2-dG:N2-dG carbinolamine DNA cross-link by the trans-4-Hydroxynonenal-derived (6S,8R,11S) 1,N2-dG adduct, J. Am. Chem. Soc., 133, 16101, 10.1021\u002Fja205145q",{"doi":5784},"10.1021\u002Fja205145q",{"id":28,"text":5786,"url":28,"identifiers":5787},"Choudhury, 2013, Repair kinetics of acrolein- and (E)-4-hydroxy-2-nonenal-derived DNA adducts in human colon cell extracts, Mutat. Res. Fund. Mol. Mech. Mutagen., 751, 15, 10.1016\u002Fj.mrfmmm.2013.09.004",{"doi":5788},"10.1016\u002Fj.mrfmmm.2013.09.004",{"id":28,"text":5790,"url":28,"identifiers":5791},"Choudhury, 2004, Repair kinetics of trans-4-hydroxynonenal-induced cyclic 1,N2-propanodeoxyguanine DNA adducts by human cell nuclear extracts, Biochemistry, 43, 7514, 10.1021\u002Fbi049877r",{"doi":5792},"10.1021\u002Fbi049877r",{"id":28,"text":5794,"url":28,"identifiers":5795},"Winczura, 2012, Damage of DNA and proteins by major lipid peroxidation products in genome stability, Free Radic. Res., 46, 442, 10.3109\u002F10715762.2012.658516",{"doi":5796},"10.3109\u002F10715762.2012.658516",{"id":28,"text":5798,"url":28,"identifiers":5799},"Janowska, 2009, Nucleotide excision repair and recombination are engaged in repair of trans-4-hydroxy-2-nonenal adducts to DNA bases in Escherichia coli, Int. J. Biol. Sci., 5, 611, 10.7150\u002Fijbs.5.611",{"doi":5800},"10.7150\u002Fijbs.5.611",{"id":28,"text":5802,"url":28,"identifiers":5803},"Banerjee, 2012, Replication bypass of the trans-4-Hydroxynonenal-derived (6S,8R,11S)-1,N2-deoxyguanosine DNA adduct by the Sulfolobus solfataricus DNA polymerase IV, Chem. Res. Toxicol., 25, 422, 10.1021\u002Ftx200460j",{"doi":5804},"10.1021\u002Ftx200460j",{"id":28,"text":5806,"url":28,"identifiers":5807},"Janowska, 2012, Role of damage-specific DNA polymerases in M13 phage mutagenesis induced by a major lipid peroxidation product trans-4-hydroxy-2-nonenal, Mutat. Res. Fund. Mol. Mech. Mutagen., 729, 41, 10.1016\u002Fj.mrfmmm.2011.09.006",{"doi":5808},"10.1016\u002Fj.mrfmmm.2011.09.006",{"id":28,"text":5810,"url":28,"identifiers":5811},"Chen, 1998, 2,3-Epoxy-4-hydroxynonanal, a potential lipid peroxidation product for etheno adduct formation, is not a substrate of human epoxide hydrolase, Carcinogenesis, 19, 939, 10.1093\u002Fcarcin\u002F19.5.939",{"doi":5812},"10.1093\u002Fcarcin\u002F19.5.939",{"id":28,"text":5814,"url":28,"identifiers":5815},"Lee, 2005, 4-Hydroperoxy-2-nonenal-induced formation of 1,N2-etheno-2'-deoxyguanosine adducts, Chem. Res. Toxicol., 18, 780, 10.1021\u002Ftx0497088",{"doi":5816},"10.1021\u002Ftx0497088",{"id":28,"text":5818,"url":28,"identifiers":5819},"Wang, 2009, Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease, Hepatology, 50, 453, 10.1002\u002Fhep.22978",{"doi":5820},"10.1002\u002Fhep.22978",{"id":28,"text":5822,"url":28,"identifiers":5823},"Nair, 2010, High urinary excretion of lipid peroxidation-derived DNA damage in patients with cancer-prone liver diseases, Mutat. Res. Fund. Mol. Mech. Mutagen., 683, 23, 10.1016\u002Fj.mrfmmm.2009.10.002",{"doi":5824},"10.1016\u002Fj.mrfmmm.2009.10.002",{"id":28,"text":5826,"url":28,"identifiers":5827},"Grune, 1997, Evaluation of purine nucleotide loss, lipid peroxidation and ultrastructural alterations in post-hypoxic hepatocytes, J. Physiol. Lond., 498, 511, 10.1113\u002Fjphysiol.1997.sp021877",{"doi":5828},"10.1113\u002Fjphysiol.1997.sp021877",{"id":28,"text":5830,"url":28,"identifiers":5831},"Grune, 1995, Postanoxic formation of aldehydic lipid-peroxidation products in human renal tubular cells, Free Radic. Biol. Med., 18, 21, 10.1016\u002F0891-5849(94)E0093-X",{"doi":5832},"10.1016\u002F0891-5849(94)E0093-X",{"id":28,"text":5834,"url":28,"identifiers":5835},"Blasig, 1995, 4-hydroxynonenal, a novel indicator of lipid-peroxidation for reperfusion injury of the myocardium, Am. J. Physiol. Heart Circ. Physiol., 269, H14, 10.1152\u002Fajpheart.1995.269.1.H14",{"doi":5836},"10.1152\u002Fajpheart.1995.269.1.H14",{"id":28,"text":5838,"url":28,"identifiers":5839},"Grune, 1994, Metabolism of 4-hydroxynonenal, a cytotoxic lipid-peroxidation product, in ehrlich mouse ascites-cells at different proliferation stages, Cancer Res., 54, 5231",{},{"id":28,"text":5841,"url":28,"identifiers":5842},"Blasig, 1994, Formation of 4-hydroxyalkenals by the reperfusion-injured rat-heart, Cell. Biochem. Mol. Asp. Reperfus. Injury, 723, 462",{},{"id":28,"text":5844,"url":28,"identifiers":5845},"Siems, 1995, 4-hydroxynonenal formation during ischemia and reperfusion of rat small-intestine, Life Sci., 57, 785, 10.1016\u002F0024-3205(95)02006-5",{"doi":5846},"10.1016\u002F0024-3205(95)02006-5",{"id":28,"text":5848,"url":28,"identifiers":5849},"Poli, 1985, Separation and characterization of the aldehydic products of lipid-peroxidation stimulated by carbon-tetrachloride or adp iron in isolated rat hepatocytes and rat-liver microsomal suspensions, Biochem. J., 227, 629, 10.1042\u002Fbj2270629",{"doi":5850},"10.1042\u002Fbj2270629",{"id":28,"text":5852,"url":28,"identifiers":5853},"Shao, 2006, Oxidative stress in head trauma in aging, Free Radic. Biol. Med., 41, 77, 10.1016\u002Fj.freeradbiomed.2006.03.007",{"doi":5854},"10.1016\u002Fj.freeradbiomed.2006.03.007",{"id":28,"text":5856,"url":28,"identifiers":5857},"Williams, 2006, Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer’s disease, Neurobiol. Aging, 27, 1094, 10.1016\u002Fj.neurobiolaging.2005.06.004",{"doi":5858},"10.1016\u002Fj.neurobiolaging.2005.06.004",{"id":28,"text":5860,"url":28,"identifiers":5861},"Auge, 2010, Pathological aspects of lipid peroxidation, Free Radic. Res., 44, 1125, 10.3109\u002F10715762.2010.498478",{"doi":5862},"10.3109\u002F10715762.2010.498478",{"id":28,"text":5864,"url":28,"identifiers":5865},"Grune, 1993, Accumulation of aldehydic lipid peroxidation products during postanoxic reoxygenation of isolated rat hepatocytes, Free Radic. Biol. Med., 15, 125, 10.1016\u002F0891-5849(93)90051-U",{"doi":5866},"10.1016\u002F0891-5849(93)90051-U",{"id":28,"text":5868,"url":28,"identifiers":5869},"Schwarzer, 1996, Increased levels of 4-hydroxynonenal in human monocytes fed with malarial pigment hemozoin—A possible clue for hemozoin toxicity, FEBS Lett., 388, 119, 10.1016\u002F0014-5793(96)00523-6",{"doi":5870},"10.1016\u002F0014-5793(96)00523-6",{"id":28,"text":5872,"url":28,"identifiers":5873},"Gil, 2006, Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes, Free Radic. Res., 40, 495, 10.1080\u002F10715760600592962",{"doi":5874},"10.1080\u002F10715760600592962",{"id":28,"text":5876,"url":28,"identifiers":5877},"Selley, 1989, Determination of the lipid-peroxidation product trans-4-hydroxy-2-nonenal in biological samples by high-performance liquid-chromatography and combined capillary column gas chromatography negative-ion chemical ionization mass-spectrometry, J. Chromatogr. Biomed. Appl., 488, 329, 10.1016\u002FS0378-4347(00)82957-6",{"doi":5878},"10.1016\u002FS0378-4347(00)82957-6",{"id":28,"text":5880,"url":28,"identifiers":5881},"Schmidt, 1996, Increased levels of lipid peroxidation products malondialdehyde and 4-hydroxynonenal after perinatal hypoxia, Pediatr. Res., 40, 15, 10.1203\u002F00006450-199607000-00003",{"doi":5882},"10.1203\u002F00006450-199607000-00003",{"id":28,"text":5884,"url":28,"identifiers":5885},"Michel, 1997, Increased lipid peroxidation in children with autoimmune diseases, Acta Paediatr., 86, 609, 10.1111\u002Fj.1651-2227.1997.tb08943.x",{"doi":5886},"10.1111\u002Fj.1651-2227.1997.tb08943.x",{"id":28,"text":5888,"url":28,"identifiers":5889},"Uchida, 1995, Characterization of epitopes recognized by 4-hydroxy-2-nonenal specific antibodies, Arch. Biochem. Biophys., 324, 241, 10.1006\u002Fabbi.1995.0036",{"doi":5890},"10.1006\u002Fabbi.1995.0036",{"id":28,"text":5892,"url":28,"identifiers":5893},"Yoritaka, 1996, Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease, Proc. Natl. Acad. Sci. USA, 93, 2696, 10.1073\u002Fpnas.93.7.2696",{"doi":5894},"10.1073\u002Fpnas.93.7.2696",{"id":28,"text":5896,"url":28,"identifiers":5897},"Okamoto, 1994, Formation of 8-hydroxy-2'-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins in human renal-cell carcinoma, Int. J. Cancer, 58, 825, 10.1002\u002Fijc.2910580613",{"doi":5898},"10.1002\u002Fijc.2910580613",{"id":28,"text":5900,"url":28,"identifiers":5901},"Ando, 1997, Oxidative stress is found in amyloid deposits in systemic amyloidosis, Biochem. Biophys. Res. Commun., 232, 497, 10.1006\u002Fbbrc.1996.5997",{"doi":5902},"10.1006\u002Fbbrc.1996.5997",{"id":28,"text":5904,"url":28,"identifiers":5905},"Butterfield, 2006, Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment, Neurosci. Lett., 397, 170, 10.1016\u002Fj.neulet.2005.12.017",{"doi":5906},"10.1016\u002Fj.neulet.2005.12.017",{"id":28,"text":5908,"url":28,"identifiers":5909},"Morikawa, 1997, Increased mitochondrial damage by lipid peroxidation in trophoblast cells of preeclamptic placentas, Biochem. Mol. Biol. Int., 41, 767",{},{"id":28,"text":5911,"url":28,"identifiers":5912},"Hamilton, 1998, Potential involvement of 4-hydroxynonenal in the response of human lung cells to ozone, Am. J. Physiol. Lung Cell. Mol. Physiol., 274, L8, 10.1152\u002Fajplung.1998.274.1.L8",{"doi":5913},"10.1152\u002Fajplung.1998.274.1.L8",{"id":28,"text":5915,"url":28,"identifiers":5916},"Liu, 2006, Detection and quantification of endogenous cyclic DNA adducts derived from trans-4-hydroxy-2-nonenal in human brain tissue by isotope dilution capillary liquid chromatography nanoelectrospray tandem mass spectrometry, Chem. Res. Toxicol., 19, 710, 10.1021\u002Ftx0502903",{"doi":5917},"10.1021\u002Ftx0502903",{"id":28,"text":5919,"url":28,"identifiers":5920},"Surh, 2005, Estimation of daily exposure to 4-hydroxy-2-alkenals in Korean foods containing n-3 and n-6 polyunsaturated fatty acids, Food Addit. Contam., 22, 701, 10.1080\u002F02652030500164359",{"doi":5921},"10.1080\u002F02652030500164359",{"id":28,"text":5923,"url":28,"identifiers":5924},"Ito, 2003, Protective effect of S-allyl-L-cysteine, a garlic compound, on amyloid beta-protein-induced cell death in nerve growth factor-differentiated PC12 cells, Neurosci. Res., 46, 119, 10.1016\u002FS0168-0102(03)00037-3",{"doi":5925},"10.1016\u002FS0168-0102(03)00037-3",{"id":28,"text":5927,"url":28,"identifiers":5928},"Glei, 2006, Both wheat (Triticum aestivum) bran arabinoxylans and gut flora-mediated fermentation products protect human colon cells from genotoxic activities of 4-hydroxynonenal and hydrogen peroxide, J. Agric. Food Chem., 54, 2088, 10.1021\u002Fjf052768e",{"doi":5929},"10.1021\u002Fjf052768e",{"id":28,"text":5931,"url":28,"identifiers":5932},"Loguercio, 2005, Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases, J. Clin. Gastroenterol., 39, 540, 10.1097\u002F01.mcg.0000165671.25272.0f",{"doi":5933},"10.1097\u002F01.mcg.0000165671.25272.0f",{"id":28,"text":5935,"url":28,"identifiers":5936},"Chowdhury, 2002, Lipid peroxidation in rat brain is increased by simulated weightlessness and decreased by a soy-protein diet, Ann. Clin. Lab. Sci., 32, 188",{},{"id":28,"text":5938,"url":28,"identifiers":5939},"Skrzydlewska, 2002, Protective effect of green tea against lipid peroxidation in the rat liver, blood serum and the brain, Phytomedicine, 9, 232, 10.1078\u002F0944-7113-00119",{"doi":5940},"10.1078\u002F0944-7113-00119",{"id":28,"text":5942,"url":28,"identifiers":5943},"Leiphon, 2007, Inhibition of aldehyde detoxification in CNS mitochondria by fungicides, Neurotoxicology, 28, 143, 10.1016\u002Fj.neuro.2006.08.008",{"doi":5944},"10.1016\u002Fj.neuro.2006.08.008",{"id":28,"text":5946,"url":28,"identifiers":5947},"Ullrich, 1994, Identification of metabolic pathways of the lipid-peroxidation product 4-hydroxynonenal by mitochondria isolated from rat-kidney cortex, FEBS Lett., 352, 84, 10.1016\u002F0014-5793(94)00922-8",{"doi":5948},"10.1016\u002F0014-5793(94)00922-8",{"id":28,"text":5950,"url":28,"identifiers":5951},"Siems, 1997, Metabolic fate of 4-hydroxynonenal in hepatocytes: 1,4-dihydroxynonene is not the main product, J. Lipid Res., 38, 612, 10.1016\u002FS0022-2275(20)37269-2",{"doi":5952},"10.1016\u002FS0022-2275(20)37269-2",{"id":28,"text":5954,"url":28,"identifiers":5955},"Siems, 1998, High capacity of secondary antioxidative pathways in thymocytes: Rapid detoxification of 4-hydroxynonenal, Int. J. Thymol., 6, 518",{},{"id":28,"text":5957,"url":28,"identifiers":5958},"Ullrich, 1997, Intracellular metabolism of 4-hydroxynonenal in primary cultures of rabbit synovial fibroblasts, Free Radic. Biol. Med., 22, 1153, 10.1016\u002FS0891-5849(96)00496-0",{"doi":5959},"10.1016\u002FS0891-5849(96)00496-0",{"id":28,"text":5961,"url":28,"identifiers":5962},"Grune, 1997, Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal in in situ perfused rat kidney, J. Lipid Res., 38, 1660, 10.1016\u002FS0022-2275(20)37184-4",{"doi":5963},"10.1016\u002FS0022-2275(20)37184-4",{"id":28,"text":5965,"url":28,"identifiers":5966},"Grune, 1991, Identification of metabolic pathways of the lipid-peroxidation product 4-hydroxynonenal by enterocytes of rat small-intestine, Biochem. Int., 25, 963",{},{"id":28,"text":5968,"url":28,"identifiers":5969},"Petras, 1995, 4-hydroxynonenal is degraded to mercapturic acid conjugate in rat-kidney, Free Radic. Biol. Med., 19, 685, 10.1016\u002F0891-5849(95)00060-B",{"doi":5970},"10.1016\u002F0891-5849(95)00060-B",{"id":28,"text":5972,"url":28,"identifiers":5973},"Kinter, 1996, Glutathione consumption and glutathione peroxidase inactivation in fibroblast cell lines by 4-hydroxy-2-nonenal, Free Radic. Biol. Med., 21, 457, 10.1016\u002F0891-5849(96)00128-1",{"doi":5974},"10.1016\u002F0891-5849(96)00128-1",{"id":28,"text":5976,"url":28,"identifiers":5977},"Esterbauer, 1985, Metabolism of the lipid-peroxidation product 4-hydroxynonenal by isolated hepatocytes and by liver cytosolic fractions, Biochem. J., 228, 363, 10.1042\u002Fbj2280363",{"doi":5978},"10.1042\u002Fbj2280363",{"id":28,"text":5980,"url":28,"identifiers":5981},"Fauler, G. (1987). Investigations on the Metabolism of 4-Hydroxy-Alkenals. [Ph.D. Thesis, University of Graz].",{},{"id":28,"text":5983,"url":28,"identifiers":5984},"Siems, 1990, Metabolic pathways of lipid peroxidation product 4-hydroxynonenal in hepatocytes quantitative assessment of an antioxidative defense system, Free Radic. Biol. Med., 9, 110, 10.1016\u002F0891-5849(90)90564-Y",{"doi":5985},"10.1016\u002F0891-5849(90)90564-Y",{"id":28,"text":5987,"url":28,"identifiers":5988},"1991, Biological effects of aldehydes with particular attention to hydroxynonenal and malondialdehyde, Membrane Lipid Peroxidation, Volume 3, 141",{},{"id":28,"text":5990,"url":28,"identifiers":5991},"Esterbauer, 1991, Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes, Free Radic. Biol. Med., 11, 81, 10.1016\u002F0891-5849(91)90192-6",{"doi":5992},"10.1016\u002F0891-5849(91)90192-6",{"id":28,"text":5994,"url":28,"identifiers":5995},"Poli, G., Albano, E., and Dianzani, M.U. (1993). Free Radicals: From Basic Science to Medicine, Birkhäuser Verlag.",{"doi":5996},"10.1007\u002F978-3-0348-9116-5",{"id":28,"text":5998,"url":28,"identifiers":5999},"Siems, 1992, Qualitative and quantitative-determination of metabolites of the lipid-peroxidation product 4-hydroxynonenal from hepatocytes, enterocytes and tumor-cells, Fresenius J. Anal. Chem., 343, 75, 10.1007\u002FBF00332017",{"doi":6000},"10.1007\u002FBF00332017",{"id":28,"text":6002,"url":28,"identifiers":6003},"Canuto, 1993, Effects of aldehyde products of lipid peroxidation on the activity of aldehyde metabolizing enzymes in hepatomas, Adv. Exp. Med. Biol., 328, 17, 10.1007\u002F978-1-4615-2904-0_3",{"doi":6004},"10.1007\u002F978-1-4615-2904-0_3",{"id":28,"text":6006,"url":28,"identifiers":6007},"Canuto, 1993, Ability of different hepatoma-cells to metabolize 4-hydroxynonenal, Cell Biochem. Funct., 11, 79, 10.1002\u002Fcbf.290110202",{"doi":6008},"10.1002\u002Fcbf.290110202",{"id":28,"text":6010,"url":28,"identifiers":6011},"Ferro, 1988, Metabolism of 4-hydroxynonenal by the rat hepatoma-cell line MH1C1, Cell Biochem. Funct., 6, 245, 10.1002\u002Fcbf.290060405",{"doi":6012},"10.1002\u002Fcbf.290060405",{"id":28,"text":6014,"url":28,"identifiers":6015},"Weiner, H., Wermuth, M.B., and Crabb, D.W. (1990, January 12–15). Metabolism of 4 hydroxynonenal in hepatoma cell lines. Advances in Experimental Medicine and Biology, Vol. 284. Enzymology and Molecular Biology of Carbonyl Metabolism 3, Proceedings of the Fifth International Workshop, West Lafayette, IN, USA.",{"doi":6016},"10.1007\u002F978-1-4684-5901-2",{"id":28,"text":6018,"url":28,"identifiers":6019},"Srivastava, 2001, Identification of biochemical pathways for the metabolism of oxidized low-density lipoprotein derived aldehyde-4-hydroxy trans-2-nonenal in vascular smooth muscle cells, Atherosclerosis, 158, 339, 10.1016\u002FS0021-9150(01)00454-3",{"doi":6020},"10.1016\u002FS0021-9150(01)00454-3",{"id":28,"text":6022,"url":28,"identifiers":6023},"Srivastava, 1998, Metabolism of the lipid peroxidation product, 4-hydroxy-trans-2-nonenal, in isolated perfused rat heart, J. Biol. Chem., 273, 10893, 10.1074\u002Fjbc.273.18.10893",{"doi":6024},"10.1074\u002Fjbc.273.18.10893",{"id":28,"text":6026,"url":28,"identifiers":6027},"Spitz, 1990, Cytotoxicity and metabolism of 4-hydroxy-2-nonenal and 2-nonenal in H2O2-resistant cell-lines—Do aldehydic by-products of lipid-peroxidation contribute to oxidative stress, Biochem. J., 267, 453, 10.1042\u002Fbj2670453",{"doi":6028},"10.1042\u002Fbj2670453",{"id":28,"text":6030,"url":28,"identifiers":6031},"Meyer, 2004, Metabohom of 4-hydroxy-trans-2-nonenal by central nervous system mitochondria is dependent on age and NAD(+) availability, Chem. Res. Toxicol., 17, 1272, 10.1021\u002Ftx049843k",{"doi":6032},"10.1021\u002Ftx049843k",{"id":28,"text":6034,"url":28,"identifiers":6035},"Canuto, 1989, Oxidative-metabolism of 4-hydroxy-2,3-nonenal during diethyl-nitrosamine-induced carcinogenesis in rat-liver, Cancer Lett., 46, 7, 10.1016\u002F0304-3835(89)90208-5",{"doi":6036},"10.1016\u002F0304-3835(89)90208-5",{"id":28,"text":6038,"url":28,"identifiers":6039},"Chen, 1996, Detoxification of reactive aldehydes in mitochondria: Effects of age and dietary restriction, Aging Clin. Exp. Res., 8, 334, 10.1007\u002FBF03339590",{"doi":6040},"10.1007\u002FBF03339590",{"id":28,"text":6042,"url":28,"identifiers":6043},"Honzatko, 2005, Enantioselective metabolism of trans-4-hydroxy-2-nonenal by brain mitochondria, Free Radic. Biol. Med., 39, 913, 10.1016\u002Fj.freeradbiomed.2005.05.010",{"doi":6044},"10.1016\u002Fj.freeradbiomed.2005.05.010",{"id":28,"text":6046,"url":28,"identifiers":6047},"Alary, 2003, Fate of 4-hydroxynonenal in vivo: Disposition and metabolic pathways, Mol. Asp. Med., 24, 177, 10.1016\u002FS0098-2997(03)00012-8",{"doi":6048},"10.1016\u002FS0098-2997(03)00012-8",{"id":28,"text":6050,"url":28,"identifiers":6051},"Alary, 1995, Mercapturic acid conjugates as urinary end metabolites of the lipid-peroxidation product 4-hydroxy-2-nonenal in the rat, Chem. Res. Toxicol., 8, 34, 10.1021\u002Ftx00043a004",{"doi":6052},"10.1021\u002Ftx00043a004",{"id":28,"text":6054,"url":28,"identifiers":6055},"Winter, 1987, Distribution of trans-4-hydroxy-2-hexenal and tandem mass-spectrometric detection of its urinary mercapturic acid in the rat, Drug Metab. Dispos., 15, 608",{},{"id":28,"text":6057,"url":28,"identifiers":6058},"Alin, 1985, 4-hydroxyalk-2-enals are substrates for glutathione transferase, FEBS Lett., 179, 267, 10.1016\u002F0014-5793(85)80532-9",{"doi":6059},"10.1016\u002F0014-5793(85)80532-9",{"id":28,"text":6061,"url":28,"identifiers":6062},"Danielson, 1987, Structure-activity-relationships of 4-hydroxyalkenals in the conjugation catalyzed by mammalian glutathione transferases, Biochem. J., 247, 707, 10.1042\u002Fbj2470707",{"doi":6063},"10.1042\u002Fbj2470707",{"id":28,"text":6065,"url":28,"identifiers":6066},"Mitchell, 1987, The oxidation of α,β-unsaturated aldehydic products of lipid-peroxidation by rat-liver aldehyde dehydrogenases, Toxicol. Appl. Pharmacol., 87, 403, 10.1016\u002F0041-008X(87)90245-6",{"doi":6067},"10.1016\u002F0041-008X(87)90245-6",{"id":28,"text":6069,"url":28,"identifiers":6070},"Mitchell, 1991, Inhibition of rat hepatic mitochondrial aldehyde dehydrogenase mediated acetaldehyde oxidation by trans-4-hydroxy-2-nonenal, Hepatology, 13, 728",{},{"id":28,"text":6072,"url":28,"identifiers":6073},"Hartley, 1995, The hepatocellular metabolism of 4-hydroxynonenal by alcohol-dehydrogenase, aldehyde dehydrogenase, and glutathione-S-transferase, Arch. Biochem. Biophys., 316, 197, 10.1006\u002Fabbi.1995.1028",{"doi":6074},"10.1006\u002Fabbi.1995.1028",{"id":28,"text":6076,"url":28,"identifiers":6077},"Singhal, 1994, Several closely-related glutathione-S-transferase isozymes catalyzing conjugation of 4-hydroxynonenal are differentially expressed in human tissues, Arch. Biochem. Biophys., 311, 242, 10.1006\u002Fabbi.1994.1233",{"doi":6078},"10.1006\u002Fabbi.1994.1233",{"id":28,"text":6080,"url":28,"identifiers":6081},"Berhane, 1994, Detoxication of base propenals and other α,β-unsaturated aldehyde products of radical reactions and lipid-peroxidation by human glutathione transferases, Proc. Natl. Acad. Sci. USA, 91, 1480, 10.1073\u002Fpnas.91.4.1480",{"doi":6082},"10.1073\u002Fpnas.91.4.1480",{"id":28,"text":6084,"url":28,"identifiers":6085},"Fukuda, 1997, Cellular response to the redox active lipid peroxidation products: Induction of glutathione S-transferase P by 4-hydroxy-2-nonenal, Biochem. Biophys. Res. Commun., 236, 505, 10.1006\u002Fbbrc.1997.6585",{"doi":6086},"10.1006\u002Fbbrc.1997.6585",{"id":28,"text":6088,"url":28,"identifiers":6089},"Yang, 2004, Glutathione-S-transferase A4-4 modulates oxidative stress in endothelium: Possible role in human atherosclerosis, Atherosclerosis, 173, 211, 10.1016\u002Fj.atherosclerosis.2003.12.023",{"doi":6090},"10.1016\u002Fj.atherosclerosis.2003.12.023",{"id":28,"text":6092,"url":28,"identifiers":6093},"Cao, 2003, The role of chemically induced glutathione and glutathione S-transferase in protecting against 4-hydroxy-2-nonenal-mediated cytotoxicity in vascular smooth muscle cells, Cardiovas. Toxicol., 3, 165, 10.1385\u002FCT:3:2:165",{"doi":6094},"10.1385\u002FCT:3:2:165",{"id":28,"text":6096,"url":28,"identifiers":6097},"Kaiserova, 2006, Redox activation of aldose reductase in the ischemic heart, J. Biol. Chem., 281, 15110, 10.1074\u002Fjbc.M600837200",{"doi":6098},"10.1074\u002Fjbc.M600837200",{"id":28,"text":6100,"url":28,"identifiers":6101},"Kolb, 1995, Substrate specificity of human aldose reductase: Identification of 4-hydroxynonenal as an endogenous substrate, Biochim. Biophys. Acta, 1249, 117, 10.1016\u002F0167-4838(95)00021-L",{"doi":6102},"10.1016\u002F0167-4838(95)00021-L",{"id":28,"text":6104,"url":28,"identifiers":6105},"Srivastava, 1984, Aldose and aldehyde reductases in human-tissues, Biochim. Biophys. Acta, 800, 220, 10.1016\u002F0304-4165(84)90399-4",{"doi":6106},"10.1016\u002F0304-4165(84)90399-4",{"id":28,"text":6108,"url":28,"identifiers":6109},"He, 1998, Reduction of 4-hydroxynonenal and 4-hydroxyhexenal by retinal aldose reductase, Biochem. Biophys. Res. Commun., 247, 719, 10.1006\u002Fbbrc.1998.8845",{"doi":6110},"10.1006\u002Fbbrc.1998.8845",{"id":28,"text":6112,"url":28,"identifiers":6113},"Srivastava, 2011, Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders, Chem. Biol. Interact., 191, 330, 10.1016\u002Fj.cbi.2011.02.023",{"doi":6114},"10.1016\u002Fj.cbi.2011.02.023",{"id":28,"text":6116,"url":28,"identifiers":6117},"Koh, 2000, Aldehyde reductase gene expression by lipid peroxidation end products, MDA and HNE, Free Radic. Res., 33, 739, 10.1080\u002F10715760000301261",{"doi":6118},"10.1080\u002F10715760000301261",{"id":28,"text":6120,"url":28,"identifiers":6121},"Hoehn, 2013, Protein oxidation in aging and the removal of oxidized proteins, J. Proteomics, 92, 132, 10.1016\u002Fj.jprot.2013.01.004",{"doi":6122},"10.1016\u002Fj.jprot.2013.01.004",{"id":28,"text":6124,"url":28,"identifiers":6125},"Grune, 1997, Breakdown of oxidized proteins as a part of secondary antioxidant defenses in mammalian cells, Biofactors, 6, 165, 10.1002\u002Fbiof.5520060210",{"doi":6126},"10.1002\u002Fbiof.5520060210",{"id":28,"text":6128,"url":28,"identifiers":6129},"Grune, 1997, Degradation of oxidized proteins in mammalian cells, FASEB J., 11, 526, 10.1096\u002Ffasebj.11.7.9212076",{"doi":6130},"10.1096\u002Ffasebj.11.7.9212076",{"id":28,"text":6132,"url":28,"identifiers":6133},"Laurent, 2000, Metabolism of 4-hydroxynonenal, a cytotoxic product of lipid peroxidation, in rat precision-cut liver slices, Toxicol. Lett., 114, 203, 10.1016\u002FS0378-4274(99)00301-X",{"doi":6134},"10.1016\u002FS0378-4274(99)00301-X",{"id":28,"text":6136,"url":28,"identifiers":6137},"Alary, 1998, Identification of novel urinary metabolites of the lipid peroxidation product 4-hydroxy-2-nonenal in rats, Chem. Res. Toxicol., 11, 1368, 10.1021\u002Ftx980068g",{"doi":6138},"10.1021\u002Ftx980068g",{"id":28,"text":6140,"url":28,"identifiers":6141},"Li, 2013, 4-Hydroxy-2(E)-nonenal (HNE) catabolism and formation of HNE adducts are modulated by beta oxidation of fatty acids in the isolated rat heart, Free Rad. Biol. Med., 58, 35, 10.1016\u002Fj.freeradbiomed.2013.01.005",{"doi":6142},"10.1016\u002Fj.freeradbiomed.2013.01.005",{"id":28,"text":6144,"url":28,"identifiers":6145},"Kubatova, 2006, Astrocytic biotransformation of trans-4-hydroxy-2-nonenal is dose-dependent, Chem. Res. Toxicol., 19, 844, 10.1021\u002Ftx0600393",{"doi":6146},"10.1021\u002Ftx0600393",{"id":28,"text":6148,"url":28,"identifiers":6149},"Alary, 1998, 1,4-dihydroxynonene mercapturic acid, the major end metabolite of exogenous 4-hydroxy-2-nonenal, is a physiological component of rat and human urine, Chem. Res. Toxicol., 11, 130, 10.1021\u002Ftx970139w",{"doi":6150},"10.1021\u002Ftx970139w",{"id":28,"text":6152,"url":28,"identifiers":6153},"Laurent, 1999, Analysis in the rat of 4-hydroxynonenal metabolites excreted in bile: Evidence of enterohepatic circulation of these byproducts of lipid peroxidation, Chem. Res. Toxicol., 12, 887, 10.1021\u002Ftx9900425",{"doi":6154},"10.1021\u002Ftx9900425",{"id":28,"text":6156,"url":28,"identifiers":6157},"Ji, 2002, Multidrug resistance-associated protein2 (MRP2) plays an important role in the biliary excretion of glutathione conjugates of 4-hydroxynonenal, Free Rad. Biol. Med., 33, 370, 10.1016\u002FS0891-5849(02)00906-1",{"doi":6158},"10.1016\u002FS0891-5849(02)00906-1",{"id":28,"text":6160,"url":28,"identifiers":6161},"Esterbauer, 1976, Reaction of cysteine with α,β-unsaturated aldehydes, Tetrahedron, 32, 285, 10.1016\u002F0040-4020(76)87015-9",{"doi":6162},"10.1016\u002F0040-4020(76)87015-9",{"id":28,"text":6164,"url":28,"identifiers":6165},"Grune, 1997, Increased levels of 4-hydroxynonenal modified proteins in plasma of children with autoimmune diseases, Free Rad. Biol. Med., 23, 357, 10.1016\u002FS0891-5849(96)00586-2",{"doi":6166},"10.1016\u002FS0891-5849(96)00586-2",{"id":28,"text":6168,"url":28,"identifiers":6169},"Peiro, 2005, Dihydroxynonene mercapturic acid, a urinary metabolite of 4-hydroxynonenal, as a biomarker of lipid peroxidation, Biofactors, 24, 89, 10.1002\u002Fbiof.5520240110",{"doi":6170},"10.1002\u002Fbiof.5520240110",{"id":28,"text":6172,"url":28,"identifiers":6173},"Volkel, 2006, Increased brain levels of 4-hydroxy-2-nonenal glutathione conjugates in severe Alzheimer’s disease, Neurochem. Int., 48, 679, 10.1016\u002Fj.neuint.2005.12.003",{"doi":6174},"10.1016\u002Fj.neuint.2005.12.003",{"id":28,"text":6176,"url":28,"identifiers":6177},"Ramana, 2006, Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE)—Role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth, J. Biol. Chem., 281, 17652, 10.1074\u002Fjbc.M600270200",{"doi":6178},"10.1074\u002Fjbc.M600270200",{"id":28,"text":6180,"url":28,"identifiers":6181},"Ramana, 2006, Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition, Circulation, 114, 1838, 10.1161\u002FCIRCULATIONAHA.106.630830",{"doi":6182},"10.1161\u002FCIRCULATIONAHA.106.630830",{"id":28,"text":6184,"url":28,"identifiers":6185},"Srivastava, 2006, Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells, Diabetes, 55, 901, 10.2337\u002Fdiabetes.55.04.06.db05-0932",{"doi":6186},"10.2337\u002Fdiabetes.55.04.06.db05-0932",{"id":28,"text":6188,"url":28,"identifiers":6189},"Tammali, 2006, Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells, Cancer Res., 66, 9705, 10.1158\u002F0008-5472.CAN-06-2105",{"doi":6190},"10.1158\u002F0008-5472.CAN-06-2105",{"id":28,"text":6192,"url":28,"identifiers":6193},"Ronis, 2005, Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition, Free Rad. Biol. Med., 39, 619, 10.1016\u002Fj.freeradbiomed.2005.04.011",{"doi":6194},"10.1016\u002Fj.freeradbiomed.2005.04.011",{"id":28,"text":6196,"url":28,"identifiers":6197},"Arakawa, 2006, N-acetylcysteine selectively protects cerebellar granule cells from 4-hydroxynonenal-induced cell death, Neurosci. Res., 55, 255, 10.1016\u002Fj.neures.2006.03.008",{"doi":6198},"10.1016\u002Fj.neures.2006.03.008",{"id":28,"text":6200,"url":28,"identifiers":6201},"Zheng, 2005, Calorie restriction delays lipid oxidative damage in Drosophila melanogaster, Aging Cell, 4, 209, 10.1111\u002Fj.1474-9726.2005.00159.x",{"doi":6202},"10.1111\u002Fj.1474-9726.2005.00159.x",{"id":28,"text":6204,"url":28,"identifiers":6205},"Lee, 2004, Suppression of apoptosis by calorie restriction in aged kidney, Exp. Gerontol., 39, 1361, 10.1016\u002Fj.exger.2004.06.015",{"doi":6206},"10.1016\u002Fj.exger.2004.06.015",{"id":28,"text":6208,"url":28,"identifiers":6209},"Zainal, 2000, Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle, FASEB J., 14, 1825, 10.1096\u002Ffj.99-0881com",{"doi":6210},"10.1096\u002Ffj.99-0881com",{"id":28,"text":6212,"url":28,"identifiers":6213},"Shoeb, 2014, 4-Hydroxynonenal in the pathogenesis and progression of human diseases, Curr. Med. Chem., 21, 230, 10.2174\u002F09298673113209990181",{"doi":6214},"10.2174\u002F09298673113209990181",{"id":6216,"createTime":6217,"updateTime":6217,"relativeEntities":6218,"slug":6219,"properties":6220,"entityType":972,"verifyStatus":26,"verifyTime":6217,"verifyNote":973,"languages":6235,"translateLanguages":28,"viewCount":32,"primaryUrl":6236,"fullTextUrl":28,"authors":6237,"publicationType":1209,"publisherRelationship":6301,"citationCount":6354,"citationInfo":6355,"publishDate":28,"publishYear":28,"citationAnalyzeStatus":881,"lastCitationAnalyze":28,"indexDatabases":6357,"openAccess":28,"references":6358,"isForceReanalyzing":2008},"30f5f1a4-ca7c-44ca-90eb-5f9848eff171","2025-02-11T03:17:06.273+00:00",[],"DOT1L-and-H3K79-Methylation-in-Transcription-and-Genomic-Stability",{"mag":6221,"pmc":6223,"openalex":6225,"abstract":6227,"title":6229,"pm":6231,"doi":6233},{"VOID":6222},"2791712220",{"VOID":6224},"5871980",{"VOID":6226},"W2791712220",{"EN":6228},"\u003Cjats:p>The organization of eukaryotic genomes into chromatin provides challenges for the cell to accomplish basic cellular functions, such as transcription, DNA replication and repair of DNA damage. Accordingly, a range of proteins modify and\u002For read chromatin states to regulate access to chromosomal DNA. Yeast Dot1 and the mammalian homologue DOT1L are methyltransferases that can add up to three methyl groups to histone H3 lysine 79 (H3K79). H3K79 methylation is implicated in several processes, including transcription elongation by RNA polymerase II, the DNA damage response and cell cycle checkpoint activation. DOT1L is also an important drug target for treatment of mixed lineage leukemia (MLL)-rearranged leukemia where aberrant transcriptional activation is promoted by DOT1L mislocalisation. This review summarizes what is currently known about the role of Dot1\u002FDOT1L and H3K79 methylation in transcription and genomic stability.\u003C\u002Fjats:p>",{"EN":6230},"DOT1L and H3K79 Methylation in Transcription and Genomic Stability",{"VOID":6232},"29495487",{"VOID":6234},"10.3390\u002Fbiom8010011",[31],"https:\u002F\u002Fwww.mdpi.com\u002F2218-273X\u002F8\u002F1\u002F11",[6238,6265,6284],{"id":6239,"sortIndex":32,"researcher":28,"roles":6240,"affiliations":6241,"properties":6258,"displayName":6262,"givenName":28,"familyName":28},"f6d5c30a-ee67-4461-bc34-6261f64e74f2",[],[6242,6250],{"id":6243,"sortIndex":32,"affiliation":6244,"properties":28},"8e57228d-5ec8-4688-8fc3-56563fe29046",{"id":6243,"createTime":28,"updateTime":28,"relativeEntities":6245,"slug":28,"properties":6246,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":6249,"statistic":28},[],{"title":6247},{"EN":6248},"Department 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1980, DNA-histone interactions in nucleosomes, Biophys. J., 32, 271, 10.1016\u002FS0006-3495(80)84956-3",{"doi":6362},"10.1016\u002FS0006-3495(80)84956-3",{"id":28,"text":6364,"url":28,"identifiers":6365},"Luger, 1997, Crystal structure of the nucleosome core particle at 2.8 a resolution, Nature, 389, 251, 10.1038\u002F38444",{"doi":6366},"10.1038\u002F38444",{"id":28,"text":6368,"url":28,"identifiers":6369},"Kornberg, 1999, Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome, Cell, 98, 285, 10.1016\u002FS0092-8674(00)81958-3",{"doi":6370},"10.1016\u002FS0092-8674(00)81958-3",{"id":28,"text":6372,"url":28,"identifiers":6373},"Zhang, 2005, Histone modifying enzymes and cancer: Going beyond histones, J. Cell. Biochem., 96, 1137, 10.1002\u002Fjcb.20615",{"doi":6374},"10.1002\u002Fjcb.20615",{"id":28,"text":6376,"url":28,"identifiers":6377},"Li, 2007, The role of chromatin during transcription, Cell, 128, 707, 10.1016\u002Fj.cell.2007.01.015",{"doi":6378},"10.1016\u002Fj.cell.2007.01.015",{"id":28,"text":6380,"url":28,"identifiers":6381},"Martin, 2005, The diverse functions of histone lysine methylation, Nat. Rev. Mol. Cell Biol., 6, 838, 10.1038\u002Fnrm1761",{"doi":6382},"10.1038\u002Fnrm1761",{"id":28,"text":6384,"url":28,"identifiers":6385},"Kouzarides, 2002, Histone methylation in transcriptional control, Curr. Opin. Genet. Dev., 12, 198, 10.1016\u002FS0959-437X(02)00287-3",{"doi":6386},"10.1016\u002FS0959-437X(02)00287-3",{"id":28,"text":6388,"url":28,"identifiers":6389},"Feinberg, 2002, Epigenetic mechanisms in human disease, Cancer Res., 62, 6784",{},{"id":28,"text":6391,"url":28,"identifiers":6392},"Handel, 2010, Epigenetics: Molecular mechanisms and implications for disease, Trends Mol. Med., 16, 7, 10.1016\u002Fj.molmed.2009.11.003",{"doi":6393},"10.1016\u002Fj.molmed.2009.11.003",{"id":28,"text":6395,"url":28,"identifiers":6396},"Jenuwein, 1998, Set domain proteins modulate chromatin domains in eu- and heterochromatin, Cell. Mol. Life Sci., 54, 80, 10.1007\u002Fs000180050127",{"doi":6397},"10.1007\u002Fs000180050127",{"id":28,"text":6399,"url":28,"identifiers":6400},"Singer, 1998, Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae, Genetics, 150, 613, 10.1093\u002Fgenetics\u002F150.2.613",{"doi":6401},"10.1093\u002Fgenetics\u002F150.2.613",{"id":28,"text":6403,"url":28,"identifiers":6404},"Feng, 2002, Methylation of H3-lysine 79 is mediated by a new family of HMTases without a set domain, Cur. Biol., 12, 1052, 10.1016\u002FS0960-9822(02)00901-6",{"doi":6405},"10.1016\u002FS0960-9822(02)00901-6",{"id":28,"text":6407,"url":28,"identifiers":6408},"Gafken, 2002, Dot1p modulates silencing in yeast by methylation of the nucleosome core, Cell, 109, 745, 10.1016\u002FS0092-8674(02)00759-6",{"doi":6409},"10.1016\u002FS0092-8674(02)00759-6",{"id":28,"text":6411,"url":28,"identifiers":6412},"Lacoste, 2002, Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase, J. Biol. Chem., 277, 30421, 10.1074\u002Fjbc.C200366200",{"doi":6413},"10.1074\u002Fjbc.C200366200",{"id":28,"text":6415,"url":28,"identifiers":6416},"Schubert, 2003, Many paths to methyltransfer: A chronicle of convergence, Trends Biochem. Sci., 28, 329, 10.1016\u002FS0968-0004(03)00090-2",{"doi":6417},"10.1016\u002FS0968-0004(03)00090-2",{"id":28,"text":6419,"url":28,"identifiers":6420},"Ng, 2002, Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association, Genes Dev., 16, 1518, 10.1101\u002Fgad.1001502",{"doi":6421},"10.1101\u002Fgad.1001502",{"id":28,"text":6423,"url":28,"identifiers":6424},"Min, 2003, Structure of the catalytic domain of human Dot1l, a non-set domain nucleosomal histone methyltransferase, Cell, 112, 711, 10.1016\u002FS0092-8674(03)00114-4",{"doi":6425},"10.1016\u002FS0092-8674(03)00114-4",{"id":28,"text":6427,"url":28,"identifiers":6428},"Nguyen, 2011, The diverse functions of Dot1 and H3K79 methylation, Genes Dev., 25, 1345, 10.1101\u002Fgad.2057811",{"doi":6429},"10.1101\u002Fgad.2057811",{"id":28,"text":6431,"url":28,"identifiers":6432},"Frederiks, 2008, Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states, Nat. Struct. Mol. Biol., 15, 550, 10.1038\u002Fnsmb.1432",{"doi":6433},"10.1038\u002Fnsmb.1432",{"id":28,"text":6435,"url":28,"identifiers":6436},"Jones, B., Su, H., Bhat, A., Lei, H., Bajko, J., Hevi, S., Baltus, G.A., Kadam, S., Zhai, H., and Valdez, R. (2008). The histone H3K79 methyltransferase DOT1L is essential for mammalian development and heterochromatin structure. PLoS Genet., 4.",{"doi":6437},"10.1371\u002Fjournal.pgen.1000190",{"id":28,"text":6439,"url":28,"identifiers":6440},"Shanower, 2005, Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase, Genetics, 169, 173, 10.1534\u002Fgenetics.104.033191",{"doi":6441},"10.1534\u002Fgenetics.104.033191",{"id":28,"text":6443,"url":28,"identifiers":6444},"Shahbazian, 2005, Histone H2b ubiquitylation controls processive methylation but not monomethylation by Dot1 and Set1, Mol. Cell, 19, 271, 10.1016\u002Fj.molcel.2005.06.010",{"doi":6445},"10.1016\u002Fj.molcel.2005.06.010",{"id":28,"text":6447,"url":28,"identifiers":6448},"Tomson, 2013, The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states, Biochem. Biophys. Acta, 1829, 116",{},{"id":28,"text":6450,"url":28,"identifiers":6451},"Briggs, 2002, Gene silencing: Trans-histone regulatory pathway in chromatin, Nature, 418, 498, 10.1038\u002Fnature00970",{"doi":6452},"10.1038\u002Fnature00970",{"id":28,"text":6454,"url":28,"identifiers":6455},"Ng, 2002, Ubiquitination of histone H2b by Rad6 is required for efficient dot1-mediated methylation of histone H3 lysine 79, J. Biol. Chem., 277, 34655, 10.1074\u002Fjbc.C200433200",{"doi":6456},"10.1074\u002Fjbc.C200433200",{"id":28,"text":6458,"url":28,"identifiers":6459},"Sun, 2002, Ubiquitination of histone H2b regulates H3 methylation and gene silencing in yeast, Nature, 418, 104, 10.1038\u002Fnature00883",{"doi":6460},"10.1038\u002Fnature00883",{"id":28,"text":6462,"url":28,"identifiers":6463},"Yao, 2015, The mediator subunit med23 couples H2b mono-ubiquitination to transcriptional control and cell fate determination, EMBO J., 34, 2885, 10.15252\u002Fembj.201591279",{"doi":6464},"10.15252\u002Fembj.201591279",{"id":28,"text":6466,"url":28,"identifiers":6467},"McGinty, 2008, Chemically ubiquitylated histone H2b stimulates HDOT1L-mediated intranucleosomal methylation, Nature, 453, 812, 10.1038\u002Fnature06906",{"doi":6468},"10.1038\u002Fnature06906",{"id":28,"text":6470,"url":28,"identifiers":6471},"Izzo, 2010, Chatting histone modifications in mammals, Brief. Funct. Genom., 9, 429, 10.1093\u002Fbfgp\u002Felq024",{"doi":6472},"10.1093\u002Fbfgp\u002Felq024",{"id":28,"text":6474,"url":28,"identifiers":6475},"Barth, 2010, Fast signals and slow marks: The dynamics of histone modifications, Trends Biochem. Sci., 35, 618, 10.1016\u002Fj.tibs.2010.05.006",{"doi":6476},"10.1016\u002Fj.tibs.2010.05.006",{"id":28,"text":6478,"url":28,"identifiers":6479},"Klose, 2006, JmjC-domain-containing proteins and histone demethylation, Nat. Rev. Genet., 7, 715, 10.1038\u002Fnrg1945",{"doi":6480},"10.1038\u002Fnrg1945",{"id":28,"text":6482,"url":28,"identifiers":6483},"Klose, 2007, Regulation of histone methylation by demethylimination and demethylation, Nat. Rev. Mol. Cell Biol., 8, 307, 10.1038\u002Fnrm2143",{"doi":6484},"10.1038\u002Fnrm2143",{"id":28,"text":6486,"url":28,"identifiers":6487},"Cloos, 2008, Erasing the methyl mark: Histone demethylases at the center of cellular differentiation and disease, Genes Dev., 22, 1115, 10.1101\u002Fgad.1652908",{"doi":6488},"10.1101\u002Fgad.1652908",{"id":28,"text":6490,"url":28,"identifiers":6491},"Liu, 2010, Phf8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression, Nature, 466, 508, 10.1038\u002Fnature09272",{"doi":6492},"10.1038\u002Fnature09272",{"id":28,"text":6494,"url":28,"identifiers":6495},"Qi, 2010, Histone H4K20\u002FH3K9 demethylase Phf8 regulates zebrafish brain and craniofacial development, Nature, 466, 503, 10.1038\u002Fnature09261",{"doi":6496},"10.1038\u002Fnature09261",{"id":28,"text":6498,"url":28,"identifiers":6499},"Milne, 2005, Leukemogenic MLL fusion proteins bind across a broad region of the Hox A9 locus, promoting transcription and multiple histone modifications, Cancer Res., 65, 11367, 10.1158\u002F0008-5472.CAN-05-1041",{"doi":6500},"10.1158\u002F0008-5472.CAN-05-1041",{"id":28,"text":6502,"url":28,"identifiers":6503},"Schulze, 2009, Linking cell cycle to histone modifications: Sbf and H2b monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation, Mol. Cell, 35, 626, 10.1016\u002Fj.molcel.2009.07.017",{"doi":6504},"10.1016\u002Fj.molcel.2009.07.017",{"id":28,"text":6506,"url":28,"identifiers":6507},"Ooga, 2008, Changes in H3K79 methylation during preimplantation development in mice, Biol. Reprod., 78, 413, 10.1095\u002Fbiolreprod.107.063453",{"doi":6508},"10.1095\u002Fbiolreprod.107.063453",{"id":28,"text":6510,"url":28,"identifiers":6511},"Ng, 2003, Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: A potential mechanism for position-effect variegation, Proc. Natl. Acad. Sci. USA, 100, 1820, 10.1073\u002Fpnas.0437846100",{"doi":6512},"10.1073\u002Fpnas.0437846100",{"id":28,"text":6514,"url":28,"identifiers":6515},"Wang, 2008, Combinatorial patterns of histone acetylations and methylations in the human genome, Nat. Genet., 40, 897, 10.1038\u002Fng.154",{"doi":6516},"10.1038\u002Fng.154",{"id":28,"text":6518,"url":28,"identifiers":6519},"Schubeler, 2004, The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote, Genes Dev., 18, 1263, 10.1101\u002Fgad.1198204",{"doi":6520},"10.1101\u002Fgad.1198204",{"id":28,"text":6522,"url":28,"identifiers":6523},"Schuettengruber, 2007, Genome regulation by polycomb and trithorax proteins, Cell, 128, 735, 10.1016\u002Fj.cell.2007.02.009",{"doi":6524},"10.1016\u002Fj.cell.2007.02.009",{"id":28,"text":6526,"url":28,"identifiers":6527},"Steger, 2008, DOT1L\u002Fkmt4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells, Mol. Cell. Biol., 28, 2825, 10.1128\u002FMCB.02076-07",{"doi":6528},"10.1128\u002FMCB.02076-07",{"id":28,"text":6530,"url":28,"identifiers":6531},"Jonkers, 2014, Genome-wide dynamics of pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons, eLife, 3, e02407, 10.7554\u002FeLife.02407",{"doi":6532},"10.7554\u002FeLife.02407",{"id":28,"text":6534,"url":28,"identifiers":6535},"Veloso, 2014, Rate of elongation by RNA polymerase II is associated with specific gene features and epigenetic modifications, Genome Res., 24, 896, 10.1101\u002Fgr.171405.113",{"doi":6536},"10.1101\u002Fgr.171405.113",{"id":28,"text":6538,"url":28,"identifiers":6539},"McKittrick, 2004, Histone H3.3 is enriched in covalent modifications associated with active chromatin, Proc. Natl. Acad. Sci. USA, 101, 1525, 10.1073\u002Fpnas.0308092100",{"doi":6540},"10.1073\u002Fpnas.0308092100",{"id":28,"text":6542,"url":28,"identifiers":6543},"Hake, 2006, Expression patterns and post-translational modifications associated with mammalian histone H3 variants, J. Biol. Chem., 281, 559, 10.1074\u002Fjbc.M509266200",{"doi":6544},"10.1074\u002Fjbc.M509266200",{"id":28,"text":6546,"url":28,"identifiers":6547},"Suzuki, 2011, Genome-wide profiling of chromatin signatures reveals epigenetic regulation of microRNA genes in colorectal cancer, Cancer Res., 71, 5646, 10.1158\u002F0008-5472.CAN-11-1076",{"doi":6548},"10.1158\u002F0008-5472.CAN-11-1076",{"id":28,"text":6550,"url":28,"identifiers":6551},"Kim, 2012, Human histone H3K79 methyltransferase DOT1L protein binds actively transcribing RNA polymerase II to regulate gene expression, J. Biol. Chem., 287, 39698, 10.1074\u002Fjbc.M112.384057",{"doi":6552},"10.1074\u002Fjbc.M112.384057",{"id":28,"text":6554,"url":28,"identifiers":6555},"Corden, 1990, Tails of RNA polymerase II, Trends Biochem. Sci., 15, 383, 10.1016\u002F0968-0004(90)90236-5",{"doi":6556},"10.1016\u002F0968-0004(90)90236-5",{"id":28,"text":6558,"url":28,"identifiers":6559},"Zaborowska, 2016, The pol II CTD: New twists in the tail, Nat. Struct. Mol. Biol., 23, 771, 10.1038\u002Fnsmb.3285",{"doi":6560},"10.1038\u002Fnsmb.3285",{"id":28,"text":6562,"url":28,"identifiers":6563},"Phatnani, 2006, Phosphorylation and functions of the RNA polymerase II CTD, Genes Dev., 20, 2922, 10.1101\u002Fgad.1477006",{"doi":6564},"10.1101\u002Fgad.1477006",{"id":28,"text":6566,"url":28,"identifiers":6567},"Wakeman, 2012, Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53bp1 foci at G1\u002FG2 cell-cycle phases, EMBO J., 31, 2169, 10.1038\u002Femboj.2012.50",{"doi":6568},"10.1038\u002Femboj.2012.50",{"id":28,"text":6570,"url":28,"identifiers":6571},"Cho, 2015, DOT1L cooperates with the c-myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression, Nat. Commun., 6, 7821, 10.1038\u002Fncomms8821",{"doi":6572},"10.1038\u002Fncomms8821",{"id":28,"text":6574,"url":28,"identifiers":6575},"Marson, 2008, Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells, Cell, 134, 521, 10.1016\u002Fj.cell.2008.07.020",{"doi":6576},"10.1016\u002Fj.cell.2008.07.020",{"id":28,"text":6578,"url":28,"identifiers":6579},"Huff, 2010, Reciprocal intronic and exonic histone modification regions in humans, Nat. Struct. Mol. Biol., 17, 1495, 10.1038\u002Fnsmb.1924",{"doi":6580},"10.1038\u002Fnsmb.1924",{"id":28,"text":6582,"url":28,"identifiers":6583},"Jung, 2012, H2b monoubiquitylation is a 5′-enriched active transcription mark and correlates with exon-intron structure in human cells, Genome Res., 22, 1026, 10.1101\u002Fgr.120634.111",{"doi":6584},"10.1101\u002Fgr.120634.111",{"id":28,"text":6586,"url":28,"identifiers":6587},"Kouskouti, 2005, Histone modifications defining active genes persist after transcriptional and mitotic inactivation, EMBO J., 24, 347, 10.1038\u002Fsj.emboj.7600516",{"doi":6588},"10.1038\u002Fsj.emboj.7600516",{"id":28,"text":6590,"url":28,"identifiers":6591},"Krogan, 2003, The Paf1 complex is required for histone H3 methylation by compass and DOT1P: Linking transcriptional elongation to histone methylation, Mol. Cell, 11, 721, 10.1016\u002FS1097-2765(03)00091-1",{"doi":6592},"10.1016\u002FS1097-2765(03)00091-1",{"id":28,"text":6594,"url":28,"identifiers":6595},"Yokoyama, 2010, A higher-order complex containing AF4 and ENL family proteins with p-Tefb facilitates oncogenic and physiologic MLL-dependent transcription, Cancer Cell, 17, 198, 10.1016\u002Fj.ccr.2009.12.040",{"doi":6596},"10.1016\u002Fj.ccr.2009.12.040",{"id":28,"text":6598,"url":28,"identifiers":6599},"Bitoun, 2007, The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling, Hum. Mol. Genet., 16, 92, 10.1093\u002Fhmg\u002Fddl444",{"doi":6600},"10.1093\u002Fhmg\u002Fddl444",{"id":28,"text":6602,"url":28,"identifiers":6603},"Biswas, 2011, Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes, Proc. Natl. Acad. Sci. USA, 108, 15751, 10.1073\u002Fpnas.1111498108",{"doi":6604},"10.1073\u002Fpnas.1111498108",{"id":28,"text":6606,"url":28,"identifiers":6607},"Mohan, 2010, Linking H3K79 trimethylation to wnt signaling through a novel Dot1-containing complex (DotCom), Genes Dev., 24, 574, 10.1101\u002Fgad.1898410",{"doi":6608},"10.1101\u002Fgad.1898410",{"id":28,"text":6610,"url":28,"identifiers":6611},"Mueller, 2007, A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification, Blood, 110, 4445, 10.1182\u002Fblood-2007-05-090514",{"doi":6612},"10.1182\u002Fblood-2007-05-090514",{"id":28,"text":6614,"url":28,"identifiers":6615},"Mueller, D., Garcia-Cuellar, M.P., Bach, C., Buhl, S., Maethner, E., and Slany, R.K. (2009). Misguided transcriptional elongation causes mixed lineage leukemia. PLoS Biol., 7.",{"doi":6616},"10.1371\u002Fjournal.pbio.1000249",{"id":28,"text":6618,"url":28,"identifiers":6619},"Lin, 2010, Aff4, a component of the Ell\u002Fp-Tefb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia, Mol. Cell, 37, 429, 10.1016\u002Fj.molcel.2010.01.026",{"doi":6620},"10.1016\u002Fj.molcel.2010.01.026",{"id":28,"text":6622,"url":28,"identifiers":6623},"Ho, 2013, DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions, Mol. Cell. Biol., 33, 1735, 10.1128\u002FMCB.01463-12",{"doi":6624},"10.1128\u002FMCB.01463-12",{"id":28,"text":6626,"url":28,"identifiers":6627},"Leach, 2013, Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding, Struct., 21, 176, 10.1016\u002Fj.str.2012.11.011",{"doi":6628},"10.1016\u002Fj.str.2012.11.011",{"id":28,"text":6630,"url":28,"identifiers":6631},"Lu, 2008, The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure, Nat. Struct. Mol. Biol., 15, 1122, 10.1038\u002Fnsmb.1489",{"doi":6632},"10.1038\u002Fnsmb.1489",{"id":28,"text":6634,"url":28,"identifiers":6635},"Qin, 2014, Structure and function of the nucleosome-binding PWWP domain, Trends Biochem. Sci., 39, 536, 10.1016\u002Fj.tibs.2014.09.001",{"doi":6636},"10.1016\u002Fj.tibs.2014.09.001",{"id":28,"text":6638,"url":28,"identifiers":6639},"Sabra, 2013, The tudor protein survival motor neuron (SMN) is a chromatin-binding protein that interacts with methylated lysine 79 of histone H3, J. Cell Sci., 126, 3664",{},{"id":28,"text":6641,"url":28,"identifiers":6642},"Huyen, 2004, Methylated lysine 79 of histone H3 targets 53bp1 to DNA double-strand breaks, Nature, 432, 406, 10.1038\u002Fnature03114",{"doi":6643},"10.1038\u002Fnature03114",{"id":28,"text":6645,"url":28,"identifiers":6646},"Alpatov, 2014, A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response, Cell, 157, 869, 10.1016\u002Fj.cell.2014.03.040",{"doi":6647},"10.1016\u002Fj.cell.2014.03.040",{"id":28,"text":6649,"url":28,"identifiers":6650},"Altaf, 2007, Interplay of chromatin modifiers on a short basic patch of histone H4 tail defines the boundary of telomeric heterochromatin, Mol. Cell, 28, 1002, 10.1016\u002Fj.molcel.2007.12.002",{"doi":6651},"10.1016\u002Fj.molcel.2007.12.002",{"id":28,"text":6653,"url":28,"identifiers":6654},"Chen, 2015, DOT1L inhibits Sirt1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia, Nat. Med., 21, 335, 10.1038\u002Fnm.3832",{"doi":6655},"10.1038\u002Fnm.3832",{"id":28,"text":6657,"url":28,"identifiers":6658},"Norris, 2010, Silent information regulator 3: The goldilocks of the silencing complex, Genes Dev., 24, 115, 10.1101\u002Fgad.1865510",{"doi":6659},"10.1101\u002Fgad.1865510",{"id":28,"text":6661,"url":28,"identifiers":6662},"Fingerman, 2007, A charge-based interaction between histone H4 and Dot1 is required for H3K79 methylation and telomere silencing: Identification of a new trans-histone pathway, Genes Dev., 21, 2018, 10.1101\u002Fgad.1560607",{"doi":6663},"10.1101\u002Fgad.1560607",{"id":28,"text":6665,"url":28,"identifiers":6666},"Rossmann, 2011, A common telomeric gene silencing assay is affected by nucleotide metabolism, Mol. Cell, 42, 127, 10.1016\u002Fj.molcel.2011.03.007",{"doi":6667},"10.1016\u002Fj.molcel.2011.03.007",{"id":28,"text":6669,"url":28,"identifiers":6670},"Takahashi, 2011, Dot1 and histone H3K79 methylation in natural telomeric and Hm silencing, Mol. Cell, 42, 118, 10.1016\u002Fj.molcel.2011.03.006",{"doi":6671},"10.1016\u002Fj.molcel.2011.03.006",{"id":28,"text":6673,"url":28,"identifiers":6674},"Wysocki, 2005, Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9, Mol. Cell. Biol., 25, 8430, 10.1128\u002FMCB.25.19.8430-8443.2005",{"doi":6675},"10.1128\u002FMCB.25.19.8430-8443.2005",{"id":28,"text":6677,"url":28,"identifiers":6678},"Botuyan, 2006, Structural basis for the methylation state-specific recognition of histone H4-K20 by 53bp1 and Crb2 in DNA repair, Cell, 127, 1361, 10.1016\u002Fj.cell.2006.10.043",{"doi":6679},"10.1016\u002Fj.cell.2006.10.043",{"id":28,"text":6681,"url":28,"identifiers":6682},"Tong, 2015, Structural plasticity of methyllysine recognition by the tandem tudor domain of 53bp1, Structure, 23, 312, 10.1016\u002Fj.str.2014.11.013",{"doi":6683},"10.1016\u002Fj.str.2014.11.013",{"id":28,"text":6685,"url":28,"identifiers":6686},"Panier, 2014, Double-strand break repair: 53bp1 comes into focus, Nat. Rev. Mol. Cell Biol., 15, 7, 10.1038\u002Fnrm3719",{"doi":6687},"10.1038\u002Fnrm3719",{"id":28,"text":6689,"url":28,"identifiers":6690},"Giannattasio, 2005, The DNA damage checkpoint response requires histone H2b ubiquitination by Rad6-Bre1 and H3 methylation by Dot1, J. Biol. Chem., 280, 9879, 10.1074\u002Fjbc.M414453200",{"doi":6691},"10.1074\u002Fjbc.M414453200",{"id":28,"text":6693,"url":28,"identifiers":6694},"Game, 2006, The Rad6\u002FBre1 histone modification pathway in saccharomyces confers radiation resistance through a Rad51-dependent process that is independent of Rad18, Genetics, 173, 1951, 10.1534\u002Fgenetics.106.057794",{"doi":6695},"10.1534\u002Fgenetics.106.057794",{"id":28,"text":6697,"url":28,"identifiers":6698},"Chernikova, 2010, Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells, Radiat. Res., 174, 558, 10.1667\u002FRR2184.1",{"doi":6699},"10.1667\u002FRR2184.1",{"id":28,"text":6701,"url":28,"identifiers":6702},"Toh, 2006, Histone H2a phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation, DNA Repair, 5, 693, 10.1016\u002Fj.dnarep.2006.03.005",{"doi":6703},"10.1016\u002Fj.dnarep.2006.03.005",{"id":28,"text":6705,"url":28,"identifiers":6706},"Grenon, 2007, Docking onto chromatin via the Saccharomyces cerevisiae Rad9 tudor domain, Yeast, 24, 105, 10.1002\u002Fyea.1441",{"doi":6707},"10.1002\u002Fyea.1441",{"id":28,"text":6709,"url":28,"identifiers":6710},"Lazzaro, 2008, Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres, EMBO J., 27, 1502",{},{"id":28,"text":6712,"url":28,"identifiers":6713},"Conde, 2009, The Dot1 histone methyltransferase and the Rad9 checkpoint adaptor contribute to cohesin-dependent double-strand break repair by sister chromatid recombination in Saccharomyces cerevisiae, Genetics, 182, 437, 10.1534\u002Fgenetics.109.101899",{"doi":6714},"10.1534\u002Fgenetics.109.101899",{"id":28,"text":6716,"url":28,"identifiers":6717},"Bostelman, 2007, Methylation of histone H3 lysine-79 by DPT1P plays multiple roles in the response to UV damage in Saccharomyces cerevisiae, DNA Repair, 6, 383, 10.1016\u002Fj.dnarep.2006.12.010",{"doi":6718},"10.1016\u002Fj.dnarep.2006.12.010",{"id":28,"text":6720,"url":28,"identifiers":6721},"Prakash, 2000, Nucleotide excision repair in yeast, Mutat. Res., 451, 13, 10.1016\u002FS0027-5107(00)00037-3",{"doi":6722},"10.1016\u002FS0027-5107(00)00037-3",{"id":28,"text":6724,"url":28,"identifiers":6725},"Conde, 2008, Role of Dot1 in the response to alkylating DNA damage in Saccharomyces cerevisiae: Regulation of DNA damage tolerance by the error-prone polymerases polzeta\u002FRev1, Genetics, 179, 1197, 10.1534\u002Fgenetics.108.089003",{"doi":6726},"10.1534\u002Fgenetics.108.089003",{"id":28,"text":6728,"url":28,"identifiers":6729},"Conde, 2010, Regulation of tolerance to DNA alkylating damage by Dot1 and Rad53 in Saccharomyces cerevisiae, DNA Repair, 9, 1038, 10.1016\u002Fj.dnarep.2010.07.003",{"doi":6730},"10.1016\u002Fj.dnarep.2010.07.003",{"id":28,"text":6732,"url":28,"identifiers":6733},"Levesque, 2010, Loss of H3 K79 trimethylation leads to suppression of Rtt107-dependent DNA damage sensitivity through the translesion synthesis pathway, J. Biol. Chem., 285, 35113, 10.1074\u002Fjbc.M110.116855",{"doi":6734},"10.1074\u002Fjbc.M110.116855",{"id":28,"text":6736,"url":28,"identifiers":6737},"Lin, 2009, Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in Calm-AF10-positive leukemias, Blood, 114, 651, 10.1182\u002Fblood-2009-03-209395",{"doi":6738},"10.1182\u002Fblood-2009-03-209395",{"id":28,"text":6740,"url":28,"identifiers":6741},"Oksenych, V., Zhovmer, A., Ziani, S., Mari, P.O., Eberova, J., Nardo, T., Stefanini, M., Giglia-Mari, G., Egly, J.M., and Coin, F. (2013). Histone methyltransferase DOT1L drives recovery of gene expression after a genotoxic attack. PLoS Genet., 9.",{"doi":6742},"10.1371\u002Fjournal.pgen.1003611",{"id":28,"text":6744,"url":28,"identifiers":6745},"Krivtsov, 2007, MLL translocations, histone modifications and leukaemia stem-cell development, Nat. Rev. Cancer, 7, 823, 10.1038\u002Fnrc2253",{"doi":6746},"10.1038\u002Fnrc2253",{"id":28,"text":6748,"url":28,"identifiers":6749},"Okada, 2005, HDOT1L links histone methylation to leukemogenesis, Cell, 121, 167, 10.1016\u002Fj.cell.2005.02.020",{"doi":6750},"10.1016\u002Fj.cell.2005.02.020",{"id":28,"text":6752,"url":28,"identifiers":6753},"Ayton, 2001, Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins, Oncogene, 20, 5695, 10.1038\u002Fsj.onc.1204639",{"doi":6754},"10.1038\u002Fsj.onc.1204639",{"id":28,"text":6756,"url":28,"identifiers":6757},"Yu, 2012, Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors, Nat. Commun., 3, 1288, 10.1038\u002Fncomms2304",{"doi":6758},"10.1038\u002Fncomms2304",{"id":28,"text":6760,"url":28,"identifiers":6761},"Stein, 2015, Mixed lineage rearranged leukaemia: Pathogenesis and targeting DOT1L, Curr. Opin. Hematol., 22, 92, 10.1097\u002FMOH.0000000000000123",{"doi":6762},"10.1097\u002FMOH.0000000000000123",{"id":28,"text":6764,"url":28,"identifiers":6765},"Basavapathruni, 2014, Nonclinical pharmacokinetics and metabolism of Epz-5676, a novel DOT1L histone methyltransferase inhibitor, Biopharm. Drug Dispos., 35, 237, 10.1002\u002Fbdd.1889",{"doi":6766},"10.1002\u002Fbdd.1889",{"id":28,"text":6768,"url":28,"identifiers":6769},"Liu, W., Deng, L., Song, Y., and Redell, M. (2014). DOT1L inhibition sensitizes MLL-rearranged aml to chemotherapy. PLoS ONE, 9.",{"doi":6770},"10.1371\u002Fjournal.pone.0098270",{"id":28,"text":6772,"url":28,"identifiers":6773},"McLean, 2014, The emerging roles of DOT1L in leukemia and normal development, Leukemia, 28, 2131, 10.1038\u002Fleu.2014.169",{"doi":6774},"10.1038\u002Fleu.2014.169",{"id":28,"text":6776,"url":28,"identifiers":6777},"Meyer, 2013, The MLL recombinome of acute leukemias in 2013, Leukemia, 27, 2165, 10.1038\u002Fleu.2013.135",{"doi":6778},"10.1038\u002Fleu.2013.135",{"id":6780,"createTime":6781,"updateTime":6781,"relativeEntities":6782,"slug":6783,"properties":6784,"entityType":972,"verifyStatus":26,"verifyTime":6781,"verifyNote":973,"languages":6799,"translateLanguages":28,"viewCount":32,"primaryUrl":6800,"fullTextUrl":28,"authors":6801,"publicationType":1209,"publisherRelationship":6859,"citationCount":215,"citationInfo":6911,"publishDate":28,"publishYear":28,"citationAnalyzeStatus":881,"lastCitationAnalyze":28,"indexDatabases":6913,"openAccess":28,"references":6914,"isForceReanalyzing":2008},"5083b5c6-e2ff-4110-beb2-baa7f5c0610a","2024-10-14T03:08:27.419+00:00",[],"Initial-Events-in-Bacterial-Transcription-Initiation",{"mag":6785,"pmc":6787,"openalex":6789,"abstract":6791,"title":6793,"pm":6795,"doi":6797},{"VOID":6786},"1551727602",{"VOID":6788},"4496709",{"VOID":6790},"W1551727602",{"EN":6792},"\u003Cjats:p>Transcription initiation is a highly regulated step of gene expression. Here, we discuss the series of large conformational changes set in motion by initial specific binding of bacterial RNA polymerase (RNAP) to promoter DNA and their relevance for regulation. Bending and wrapping of the upstream duplex facilitates bending of the downstream duplex into the active site cleft, nucleating opening of 13 bp in the cleft. The rate-determining opening step, driven by binding free energy, forms an unstable open complex, probably with the template strand in the active site. At some promoters, this initial open complex is greatly stabilized by rearrangements of the discriminator region between the −10 element and +1 base of the nontemplate strand and of mobile in-cleft and downstream elements of RNAP. The rate of open complex formation is regulated by effects on the rapidly-reversible steps preceding DNA opening, while open complex lifetime is regulated by effects on the stabilization of the initial open complex. Intrinsic DNA opening-closing appears less regulated. This noncovalent mechanism and its regulation exhibit many analogies to mechanisms of enzyme catalysis.\u003C\u002Fjats:p>",{"EN":6794},"Initial Events in Bacterial Transcription Initiation",{"VOID":6796},"26023916",{"VOID":6798},"10.3390\u002Fbiom5021035",[31],"https:\u002F\u002Fwww.mdpi.com\u002F2218-273X\u002F5\u002F2\u002F1035",[6802,6821,6840],{"id":6803,"sortIndex":32,"researcher":28,"roles":6804,"affiliations":6805,"properties":6814,"displayName":6818,"givenName":28,"familyName":28},"4fa19aad-f6b1-466d-87e5-c5918cd1c43c",[],[6806],{"id":6807,"sortIndex":32,"affiliation":6808,"properties":28},"b7b6e9cc-439e-41e5-b596-587dbd536207",{"id":6807,"createTime":28,"updateTime":28,"relativeEntities":6809,"slug":28,"properties":6810,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":6813,"statistic":28},[],{"title":6811},{"EN":6812},"Department of Biochemistry, University of Wisconsin-Madison, 1101 University Ave. Madison, Madison, WI 53706, USA. eruff@wisc.edu.",[],{"orcid":6815,"title":6817,"openalex":6819},{"VOID":6816},"https:\u002F\u002Forcid.org\u002F0009-0009-3297-7952",{"EN":6818},"Emily Ruff",{"VOID":6820},"A5040416730",{"id":6822,"sortIndex":40,"researcher":28,"roles":6823,"affiliations":6824,"properties":6833,"displayName":6837,"givenName":28,"familyName":28},"0933be84-6982-4dbc-9b0f-39a59e860352",[],[6825],{"id":6826,"sortIndex":32,"affiliation":6827,"properties":28},"52ed8d5a-8f07-4ca8-a9ef-1e6064122e74",{"id":6826,"createTime":28,"updateTime":28,"relativeEntities":6828,"slug":28,"properties":6829,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":6832,"statistic":28},[],{"title":6830},{"EN":6831},"Departments of Chemistry and Biochemistry, University of Wisconsin-Madison, 1101 University Ave. Madison, Madison, WI 53706, USA. eruff@wisc.edu.",[],{"orcid":6834,"title":6836,"openalex":6838},{"VOID":6835},"https:\u002F\u002Forcid.org\u002F0000-0003-3973-7694",{"EN":6837},"M. 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Rev. Microbiol., 67, 113, 10.1146\u002Fannurev-micro-092412-155756",{"doi":6918},"10.1146\u002Fannurev-micro-092412-155756",{"id":28,"text":6920,"url":28,"identifiers":6921},"Ebright, 2000, RNA polymerase: Structural similarities between bacterial RNA polymerase and eukaryotic RNA polymerase II, J. Mol. Biol., 304, 687, 10.1006\u002Fjmbi.2000.4309",{"doi":6922},"10.1006\u002Fjmbi.2000.4309",{"id":28,"text":6924,"url":28,"identifiers":6925},"Saecker, 2011, Mechanism of bacterial transcription initiation: RNA polymerase—Promoter binding, isomerization to initiation-competent open complexes, and initiation of RNA synthesis, J. Mol. Biol., 412, 754, 10.1016\u002Fj.jmb.2011.01.018",{"doi":6926},"10.1016\u002Fj.jmb.2011.01.018",{"id":28,"text":6928,"url":28,"identifiers":6929},"Dorman, 2013, Co-operative roles for DNA supercoiling and nucleoid-associated proteins in the regulation of bacterial transcription, Biochem. Soc. Trans., 41, 542, 10.1042\u002FBST20120222",{"doi":6930},"10.1042\u002FBST20120222",{"id":28,"text":6932,"url":28,"identifiers":6933},"Feklistov, 2014, Bacterial sigma factors: A historical, structural, and genomic perspective, Annu. Rev. Microbiol., 68, 357, 10.1146\u002Fannurev-micro-092412-155737",{"doi":6934},"10.1146\u002Fannurev-micro-092412-155737",{"id":28,"text":6936,"url":28,"identifiers":6937},"Haugen, 2008, Advances in bacterial promoter recognition and its control by factors that do not bind DNA, Nat. Rev. Microbiol., 6, 507, 10.1038\u002Fnrmicro1912",{"doi":6938},"10.1038\u002Fnrmicro1912",{"id":28,"text":6940,"url":28,"identifiers":6941},"Lee, 2012, Activating transcription in bacteria, Annu. Rev. Microbiol., 66, 125, 10.1146\u002Fannurev-micro-092611-150012",{"doi":6942},"10.1146\u002Fannurev-micro-092611-150012",{"id":28,"text":6944,"url":28,"identifiers":6945},"Bae, 2013, Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of σ70 domain 1.1, Proc. Natl. Acad. Sci. USA, 110, 19772, 10.1073\u002Fpnas.1314576110",{"doi":6946},"10.1073\u002Fpnas.1314576110",{"id":28,"text":6948,"url":28,"identifiers":6949},"Basu, 2014, Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme, J. Biol. Chem., 289, 24549, 10.1074\u002Fjbc.M114.584037",{"doi":6950},"10.1074\u002Fjbc.M114.584037",{"id":28,"text":6952,"url":28,"identifiers":6953},"Feklistov, 2011, Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit, Cell, 147, 1257, 10.1016\u002Fj.cell.2011.10.041",{"doi":6954},"10.1016\u002Fj.cell.2011.10.041",{"id":28,"text":6956,"url":28,"identifiers":6957},"Lawson, 2004, Catabolite activator protein: DNA binding and transcription activation, Curr. Opin. Struct. Biol., 14, 10, 10.1016\u002Fj.sbi.2004.01.012",{"doi":6958},"10.1016\u002Fj.sbi.2004.01.012",{"id":28,"text":6960,"url":28,"identifiers":6961},"Murakami, 2013, X-ray crystal structure of Escherichia coli RNA polymerase σ70 holoenzyme, J. Biol. Chem., 288, 9126, 10.1074\u002Fjbc.M112.430900",{"doi":6962},"10.1074\u002Fjbc.M112.430900",{"id":28,"text":6964,"url":28,"identifiers":6965},"Murakami, 2002, Structural basis of transcription initiation: An RNA polymerase holoenzyme-DNA complex, Science, 296, 1285, 10.1126\u002Fscience.1069595",{"doi":6966},"10.1126\u002Fscience.1069595",{"id":28,"text":6968,"url":28,"identifiers":6969},"Murakami, 2002, Structural basis of transcription initiation: RNA polymerase holoenzyme at 4 Å resolution, Science, 296, 1280, 10.1126\u002Fscience.1069594",{"doi":6970},"10.1126\u002Fscience.1069594",{"id":28,"text":6972,"url":28,"identifiers":6973},"Murakami, 2003, Crystallographic analysis of Thermus aquaticus RNA polymerase holoenzyme and a holoenzyme\u002Fpromoter DNA complex, Methods Enzymol., 370, 42, 10.1016\u002FS0076-6879(03)70004-4",{"doi":6974},"10.1016\u002FS0076-6879(03)70004-4",{"id":28,"text":6976,"url":28,"identifiers":6977},"Vassylyev, 2002, Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 Å resolution, Nature, 417, 712, 10.1038\u002Fnature752",{"doi":6978},"10.1038\u002Fnature752",{"id":28,"text":6980,"url":28,"identifiers":6981},"Zhang, 2012, Structural basis of transcription initiation, Science, 338, 1076, 10.1126\u002Fscience.1227786",{"doi":6982},"10.1126\u002Fscience.1227786",{"id":28,"text":6984,"url":28,"identifiers":6985},"Ruff, E.F., Drennan, A., Capp, M.W., Poulos, M.A., Artsimovitch, I., and Record, M.T. (2015). Escherichia coli RNA polymerase determinants of open complex lifetime and structure. J. Mol. Biol., In press.",{"doi":6986},"10.1016\u002Fj.jmb.2015.05.024",{"id":28,"text":6988,"url":28,"identifiers":6989},"Rutherford, S.T. (2008). Insights into the Mechanism of DksA Action at Ribosomal RNA Promoters in Escherichia coli, University of Wisconsin.",{},{"id":28,"text":6991,"url":28,"identifiers":6992},"Rammohan, 2015, CarD stabilizes mycobacterial open complexes via a two-tiered kinetic mechanism, Nucleic Acids Res., 43, 3272, 10.1093\u002Fnar\u002Fgkv078",{"doi":6993},"10.1093\u002Fnar\u002Fgkv078",{"id":28,"text":6995,"url":28,"identifiers":6996},"Friedman, 2012, Mechanism of transcription initiation at an activator-dependent promoter defined by single-molecule observation, Cell, 148, 679, 10.1016\u002Fj.cell.2012.01.018",{"doi":6997},"10.1016\u002Fj.cell.2012.01.018",{"id":28,"text":6999,"url":28,"identifiers":7000},"Heyduk, 2014, Next generation sequencing-based parallel analysis of melting kinetics of 4096 variants of a bacterial promoter, Biochemistry, 53, 282, 10.1021\u002Fbi401277w",{"doi":7001},"10.1021\u002Fbi401277w",{"id":28,"text":7003,"url":28,"identifiers":7004},"Gries, 2010, One-step DNA melting in the RNA polymerase cleft opens the initiation bubble to form an unstable open complex, Proc. Natl. Acad. Sci. USA, 107, 10418, 10.1073\u002Fpnas.1000967107",{"doi":7005},"10.1073\u002Fpnas.1000967107",{"id":28,"text":7007,"url":28,"identifiers":7008},"Kontur, 2008, Late steps in the formation of E. coli RNA polymerase-λPR promoter open complexes: Characterization of conformational changes by rapid [perturbant] upshift experiments, J. Mol. Biol., 376, 1034, 10.1016\u002Fj.jmb.2007.11.064",{"doi":7009},"10.1016\u002Fj.jmb.2007.11.064",{"id":28,"text":7011,"url":28,"identifiers":7012},"Rogozina, 2009, DNA melting by RNA polymerase at the T7A1 promoter precedes the rate-limiting step at 37 degrees C and results in the accumulation of an off-pathway intermediate, Nucleic Acids Res., 37, 5390, 10.1093\u002Fnar\u002Fgkp560",{"doi":7013},"10.1093\u002Fnar\u002Fgkp560",{"id":28,"text":7015,"url":28,"identifiers":7016},"Sclavi, 2005, Real-time characterization of intermediates in the pathway to open complex formation by Escherichia coli RNA polymerase at the T7A1 promoter, Proc. Natl. Acad. Sci. USA, 102, 4706, 10.1073\u002Fpnas.0408218102",{"doi":7017},"10.1073\u002Fpnas.0408218102",{"id":28,"text":7019,"url":28,"identifiers":7020},"Davis, 2007, Real-time footprinting of DNA in the first kinetically significant intermediate in open complex formation by Escherichia coli RNA polymerase, Proc. Natl. Acad. Sci. USA, 104, 7833, 10.1073\u002Fpnas.0609888104",{"doi":7021},"10.1073\u002Fpnas.0609888104",{"id":28,"text":7023,"url":28,"identifiers":7024},"Ko, 2014, Kinetics of promoter escape by bacterial RNA polymerase: Effects of promoter contacts and transcription bubble collapse, Biochem. J., 463, 135, 10.1042\u002FBJ20140179",{"doi":7025},"10.1042\u002FBJ20140179",{"id":28,"text":7027,"url":28,"identifiers":7028},"Mekler, 2014, Coupling of downstream RNA polymerase-promoter interactions with formation of catalytically competent transcription initiation complex, J. Mol. Biol., 426, 3973, 10.1016\u002Fj.jmb.2014.10.005",{"doi":7029},"10.1016\u002Fj.jmb.2014.10.005",{"id":28,"text":7031,"url":28,"identifiers":7032},"Mekler, 2011, A critical role of downstream RNA polymerase-promoter interactions in the formation of initiation complex, J. Biol. Chem., 286, 22600, 10.1074\u002Fjbc.M111.247080",{"doi":7033},"10.1074\u002Fjbc.M111.247080",{"id":28,"text":7035,"url":28,"identifiers":7036},"Mekler, 2011, Interaction of Escherichia coli RNA polymerase σ70 subunit with promoter elements in the context of free σ70, RNA polymerase holoenzyme, and the β'-σ70 complex, J. Biol. Chem., 286, 270, 10.1074\u002Fjbc.M110.174102",{"doi":7037},"10.1074\u002Fjbc.M110.174102",{"id":28,"text":7039,"url":28,"identifiers":7040},"Revyakin, 2004, Promoter unwinding and promoter clearance by RNA polymerase: Detection by single-molecule DNA nanomanipulation, Proc. Natl. Acad. Sci. USA, 101, 4776, 10.1073\u002Fpnas.0307241101",{"doi":7041},"10.1073\u002Fpnas.0307241101",{"id":28,"text":7043,"url":28,"identifiers":7044},"Revyakin, 2006, Abortive initiation and productive initiation by RNA polymerase involve DNA scrunching, Science, 314, 1139, 10.1126\u002Fscience.1131398",{"doi":7045},"10.1126\u002Fscience.1131398",{"id":28,"text":7047,"url":28,"identifiers":7048},"Robb, 2013, The transcription bubble of the RNA polymerase-promoter open complex exhibits conformational heterogeneity and millisecond-scale dynamics: Implications for transcription start-site selection, J. Mol. Biol., 425, 875, 10.1016\u002Fj.jmb.2012.12.015",{"doi":7049},"10.1016\u002Fj.jmb.2012.12.015",{"id":28,"text":7051,"url":28,"identifiers":7052},"Schroeder, 2009, Evidence for a tyrosine-adenine stacking interaction and for a short-lived open intermediate subsequent to initial binding of Escherichia coli RNA polymerase to promoter DNA, J. Mol. Biol., 385, 339, 10.1016\u002Fj.jmb.2008.10.023",{"doi":7053},"10.1016\u002Fj.jmb.2008.10.023",{"id":28,"text":7055,"url":28,"identifiers":7056},"Burgess, 1969, Separation and characterization of the subunits of ribonucleic acid polymerase, J. Biol. Chem., 244, 6168, 10.1016\u002FS0021-9258(18)63521-5",{"doi":7057},"10.1016\u002FS0021-9258(18)63521-5",{"id":28,"text":7059,"url":28,"identifiers":7060},"Murakami, 2003, Bacterial RNA polymerases: The wholo story, Curr. Opin. Struct. Biol., 13, 31, 10.1016\u002FS0959-440X(02)00005-2",{"doi":7061},"10.1016\u002FS0959-440X(02)00005-2",{"id":28,"text":7063,"url":28,"identifiers":7064},"Zhang, 1999, Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 Å resolution, Cell, 98, 811, 10.1016\u002FS0092-8674(00)81515-9",{"doi":7065},"10.1016\u002FS0092-8674(00)81515-9",{"id":28,"text":7067,"url":28,"identifiers":7068},"Cramer, 2001, Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution, Science, 292, 1863, 10.1126\u002Fscience.1059493",{"doi":7069},"10.1126\u002Fscience.1059493",{"id":28,"text":7071,"url":28,"identifiers":7072},"Gnatt, 2001, Structural basis of transcription: An RNA polymerase II elongation complex at 3.3 Å resolution, Science, 292, 1876, 10.1126\u002Fscience.1059495",{"doi":7073},"10.1126\u002Fscience.1059495",{"id":28,"text":7075,"url":28,"identifiers":7076},"Lane, 2010, Molecular evolution of multisubunit RNA polymerases: Sequence analysis, J. Mol. Biol., 395, 671, 10.1016\u002Fj.jmb.2009.10.062",{"doi":7077},"10.1016\u002Fj.jmb.2009.10.062",{"id":28,"text":7079,"url":28,"identifiers":7080},"Gruber, 2003, Multiple sigma subunits and the partitioning of bacterial transcription space, Annu. Rev. Microbiol., 57, 441, 10.1146\u002Fannurev.micro.57.030502.090913",{"doi":7081},"10.1146\u002Fannurev.micro.57.030502.090913",{"id":28,"text":7083,"url":28,"identifiers":7084},"Campbell, 2002, Structure of the bacterial RNA polymerase promoter specificity sigma subunit, Mol. Cell, 9, 527, 10.1016\u002FS1097-2765(02)00470-7",{"doi":7085},"10.1016\u002FS1097-2765(02)00470-7",{"id":28,"text":7087,"url":28,"identifiers":7088},"Keilty, 1987, Constitutive function of a positively regulated promoter reveals new sequences essential for activity, J. Biol. Chem., 262, 6389, 10.1016\u002FS0021-9258(18)45582-2",{"doi":7089},"10.1016\u002FS0021-9258(18)45582-2",{"id":28,"text":7091,"url":28,"identifiers":7092},"Schwartz, 2008, A full-length group 1 bacterial sigma factor adopts a compact structure incompatible with DNA binding, Chem. Biol., 15, 1091, 10.1016\u002Fj.chembiol.2008.09.008",{"doi":7093},"10.1016\u002Fj.chembiol.2008.09.008",{"id":28,"text":7095,"url":28,"identifiers":7096},"Dombroski, 1993, Amino-terminal amino acids modulate sigma-factor DNA-binding activity, Genes Dev., 7, 2446, 10.1101\u002Fgad.7.12a.2446",{"doi":7097},"10.1101\u002Fgad.7.12a.2446",{"id":28,"text":7099,"url":28,"identifiers":7100},"Wilson, 1997, Region 1 of σ70 is required for efficient isomerization and initiation of transcription by Escherichia coli RNA polymerase, J. Mol. Biol., 267, 60, 10.1006\u002Fjmbi.1997.0875",{"doi":7101},"10.1006\u002Fjmbi.1997.0875",{"id":28,"text":7103,"url":28,"identifiers":7104},"Darst, 2001, Bacterial RNA polymerase, Curr. Opin. Struct. Biol., 11, 155, 10.1016\u002FS0959-440X(00)00185-8",{"doi":7105},"10.1016\u002FS0959-440X(00)00185-8",{"id":28,"text":7107,"url":28,"identifiers":7108},"Chakraborty, 2012, Opening and closing of the bacterial RNA polymerase clamp, Science, 337, 591, 10.1126\u002Fscience.1218716",{"doi":7109},"10.1126\u002Fscience.1218716",{"id":28,"text":7111,"url":28,"identifiers":7112},"Weixlbaumer, 2013, Structural basis of transcriptional pausing in bacteria, Cell, 152, 431, 10.1016\u002Fj.cell.2012.12.020",{"doi":7113},"10.1016\u002Fj.cell.2012.12.020",{"id":28,"text":7115,"url":28,"identifiers":7116},"Tagami, 2010, Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein, Nature, 468, 978, 10.1038\u002Fnature09573",{"doi":7117},"10.1038\u002Fnature09573",{"id":28,"text":7119,"url":28,"identifiers":7120},"Ross, 2013, The magic spot: A ppGpp binding site on E. coli RNA polymerase responsible for regulation of transcription initiation, Mol. Cell, 50, 420, 10.1016\u002Fj.molcel.2013.03.021",{"doi":7121},"10.1016\u002Fj.molcel.2013.03.021",{"id":28,"text":7123,"url":28,"identifiers":7124},"Zuo, 2013, The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex, Mol. Cell, 50, 430, 10.1016\u002Fj.molcel.2013.03.020",{"doi":7125},"10.1016\u002Fj.molcel.2013.03.020",{"id":28,"text":7127,"url":28,"identifiers":7128},"Belogurov, 2009, Transcription inactivation through local refolding of the RNA polymerase structure, Nature, 457, 332, 10.1038\u002Fnature07510",{"doi":7129},"10.1038\u002Fnature07510",{"id":28,"text":7131,"url":28,"identifiers":7132},"Ho, 2009, Structures of RNA polymerase-antibiotic complexes, Curr. Opin. Struct. Biol., 19, 715, 10.1016\u002Fj.sbi.2009.10.010",{"doi":7133},"10.1016\u002Fj.sbi.2009.10.010",{"id":28,"text":7135,"url":28,"identifiers":7136},"Tupin, 2010, The transcription inhibitor lipiarmycin blocks DNA fitting into the RNA polymerase catalytic site, EMBO J., 29, 2527, 10.1038\u002Femboj.2010.135",{"doi":7137},"10.1038\u002Femboj.2010.135",{"id":28,"text":7139,"url":28,"identifiers":7140},"Chen, 2010, Promoter melting triggered by bacterial RNA polymerase occurs in three steps, Proc. Natl. Acad. Sci. USA, 107, 12523, 10.1073\u002Fpnas.1003533107",{"doi":7141},"10.1073\u002Fpnas.1003533107",{"id":28,"text":7143,"url":28,"identifiers":7144},"Cowing, 1989, Intermediates in the formation of the open complex by RNA polymerase holoenzyme containing the sigma factor σ32 at the groE promoter, J. Mol. Biol., 210, 521, 10.1016\u002F0022-2836(89)90128-9",{"doi":7145},"10.1016\u002F0022-2836(89)90128-9",{"id":28,"text":7147,"url":28,"identifiers":7148},"Craig, 1998, DNA footprints of the two kinetically significant intermediates in formation of an RNA polymerase-promoter open complex: Evidence that interactions with start site and downstream DNA induce sequential conformational changes in polymerase and DNA, J. Mol. Biol., 283, 741, 10.1006\u002Fjmbi.1998.2129",{"doi":7149},"10.1006\u002Fjmbi.1998.2129",{"id":28,"text":7151,"url":28,"identifiers":7152},"Saecker, 2002, Kinetic studies and structural models of the association of E. coli σ70 RNA polymerase with the λPR promoter: Large scale conformational changes in forming the kinetically significant intermediates, J. Mol. Biol., 319, 649, 10.1016\u002FS0022-2836(02)00293-0",{"doi":7153},"10.1016\u002FS0022-2836(02)00293-0",{"id":28,"text":7155,"url":28,"identifiers":7156},"McClure, 1985, Mechanism and control of transcription initiation in prokaryotes, Annu. Rev. Biochem., 54, 171, 10.1146\u002Fannurev.bi.54.070185.001131",{"doi":7157},"10.1146\u002Fannurev.bi.54.070185.001131",{"id":28,"text":7159,"url":28,"identifiers":7160},"Neidhardt, F.C. (1996). Escherichia coli and Salmonella Cellular and Molecular Biology, ASM Press.",{},{"id":28,"text":7162,"url":28,"identifiers":7163},"Kontur, 2010, Probing DNA binding, DNA opening, and assembly of a downstream clamp\u002Fjaw in Escherichia coli RNA polymerase-λPR promoter complexes using salt and the physiological anion glutamate, Biochemistry, 49, 4361, 10.1021\u002Fbi100092a",{"doi":7164},"10.1021\u002Fbi100092a",{"id":28,"text":7166,"url":28,"identifiers":7167},"Kontur, 2006, Solute probes of conformational changes in open complex (RPo) formation by Escherichia coli RNA polymerase at the λPR promoter: Evidence for unmasking of the active site in the isomerization step and for large-scale coupled folding in the subsequent conversion to RPo, Biochemistry, 45, 2161, 10.1021\u002Fbi051835v",{"doi":7168},"10.1021\u002Fbi051835v",{"id":28,"text":7170,"url":28,"identifiers":7171},"Roe, 1984, Kinetics and mechanism of the interaction of Escherichia coli RNA polymerase with the λPR promoter, J. Mol. Biol., 176, 495, 10.1016\u002F0022-2836(84)90174-8",{"doi":7172},"10.1016\u002F0022-2836(84)90174-8",{"id":28,"text":7174,"url":28,"identifiers":7175},"Roe, 1985, Temperature dependence of the rate constants of the Escherichia coli RNA polymerase-λPR promoter interaction. Assignment of the kinetic steps corresponding to protein conformational change and DNA opening, J. Mol. Biol., 184, 441, 10.1016\u002F0022-2836(85)90293-1",{"doi":7176},"10.1016\u002F0022-2836(85)90293-1",{"id":28,"text":7178,"url":28,"identifiers":7179},"Losick, R., and Chamberlin, M.J. (1976). RNA Polymerase, Cold Spring Harbor Laboratory.",{},{"id":28,"text":7181,"url":28,"identifiers":7182},"Gourse, 2000, UPs and downs in bacterial transcription initiation: The role of the alpha subunit of RNA polymerase in promoter recognition, Mol. Microbiol., 37, 687, 10.1046\u002Fj.1365-2958.2000.01972.x",{"doi":7183},"10.1046\u002Fj.1365-2958.2000.01972.x",{"id":28,"text":7185,"url":28,"identifiers":7186},"Ross, 1993, A third recognition element in bacterial promoters: DNA binding by the alpha subunit of RNA polymerase, Science, 262, 1407, 10.1126\u002Fscience.8248780",{"doi":7187},"10.1126\u002Fscience.8248780",{"id":28,"text":7189,"url":28,"identifiers":7190},"Estrem, 1998, Identification of an UP element consensus sequence for bacterial promoters, Proc. Natl. Acad. Sci. USA, 95, 9761, 10.1073\u002Fpnas.95.17.9761",{"doi":7191},"10.1073\u002Fpnas.95.17.9761",{"id":28,"text":7193,"url":28,"identifiers":7194},"Rao, 1994, Factor independent activation of rrnB P1. An “extended” promoter with an upstream element that dramatically increases promoter strength, J. Mol. Biol., 235, 1421, 10.1006\u002Fjmbi.1994.1098",{"doi":7195},"10.1006\u002Fjmbi.1994.1098",{"id":28,"text":7197,"url":28,"identifiers":7198},"Estrem, 1999, Bacterial promoter architecture: Subsite structure of UP elements and interactions with the carboxy-terminal domain of the RNA polymerase alpha subunit, Genes Dev., 13, 2134, 10.1101\u002Fgad.13.16.2134",{"doi":7199},"10.1101\u002Fgad.13.16.2134",{"id":28,"text":7201,"url":28,"identifiers":7202},"Gaal, 1994, Localization of the intrinsically bent DNA region upstream of the E.coli rrnB P1 promoter, Nucleic Acids Res., 22, 2344, 10.1093\u002Fnar\u002F22.12.2344",{"doi":7203},"10.1093\u002Fnar\u002F22.12.2344",{"id":28,"text":7205,"url":28,"identifiers":7206},"Koo, 1986, DNA bending at adenine · thymine tracts, Nature, 320, 501, 10.1038\u002F320501a0",{"doi":7207},"10.1038\u002F320501a0",{"id":28,"text":7209,"url":28,"identifiers":7210},"Davis, 2005, The effects of upstream DNA on open complex formation by Escherichia coli RNA polymerase, Proc. Natl. Acad. Sci. USA, 102, 285, 10.1073\u002Fpnas.0405779102",{"doi":7211},"10.1073\u002Fpnas.0405779102",{"id":28,"text":7213,"url":28,"identifiers":7214},"Mangiarotti, 2009, Sequence-dependent upstream DNA-RNA polymerase interactions in the open complex with λPR and λPRM promoters and implications for the mechanism of promoter interference, J. Mol. Biol., 385, 748, 10.1016\u002Fj.jmb.2008.11.019",{"doi":7215},"10.1016\u002Fj.jmb.2008.11.019",{"id":28,"text":7217,"url":28,"identifiers":7218},"Zuo, 2015, Crystal structures of the E. coli transcription initiation complexes with a complete bubble, Mol. Cell, 58, 534, 10.1016\u002Fj.molcel.2015.03.010",{"doi":7219},"10.1016\u002Fj.molcel.2015.03.010",{"id":28,"text":7221,"url":28,"identifiers":7222},"Ross, 2005, Sequence-independent upstream DNA-alphaCTD interactions strongly stimulate Escherichia coli RNA polymerase-lacUV5 promoter association, Proc. Natl. Acad. Sci. USA, 102, 291, 10.1073\u002Fpnas.0405814102",{"doi":7223},"10.1073\u002Fpnas.0405814102",{"id":28,"text":7225,"url":28,"identifiers":7226},"Hawley, 1983, Compilation and analysis of Escherichia coli promoter DNA sequences, Nucleic Acids Res., 11, 2237, 10.1093\u002Fnar\u002F11.8.2237",{"doi":7227},"10.1093\u002Fnar\u002F11.8.2237",{"id":28,"text":7229,"url":28,"identifiers":7230},"Lisser, 1993, Compilation of E. coli mRNA promoter sequences, Nucleic Acids Res., 21, 1507, 10.1093\u002Fnar\u002F21.7.1507",{"doi":7231},"10.1093\u002Fnar\u002F21.7.1507",{"id":28,"text":7233,"url":28,"identifiers":7234},"Ross, 2003, An intersubunit contact stimulating transcription initiation by E coli RNA polymerase: Interaction of the alpha C-terminal domain and sigma region 4, Genes Dev., 17, 1293, 10.1101\u002Fgad.1079403",{"doi":7235},"10.1101\u002Fgad.1079403",{"id":28,"text":7237,"url":28,"identifiers":7238},"Dove, 2000, Mechanism for a transcriptional activator that works at the isomerization step, Proc. Natl. Acad. Sci. USA, 97, 13215, 10.1073\u002Fpnas.97.24.13215",{"doi":7239},"10.1073\u002Fpnas.97.24.13215",{"id":28,"text":7241,"url":28,"identifiers":7242},"Chen, 2003, Functional interaction between RNA polymerase alpha subunit C-terminal domain and σ70 in UP-element- and activator-dependent transcription, Mol. Cell, 11, 1621, 10.1016\u002FS1097-2765(03)00201-6",{"doi":7243},"10.1016\u002FS1097-2765(03)00201-6",{"id":28,"text":7245,"url":28,"identifiers":7246},"Dove, 2003, Region 4 of sigma as a target for transcription regulation, Mol. Microbiol., 48, 863, 10.1046\u002Fj.1365-2958.2003.03467.x",{"doi":7247},"10.1046\u002Fj.1365-2958.2003.03467.x",{"id":28,"text":7249,"url":28,"identifiers":7250},"Niu, 1996, Transcription activation at class II CAP-dependent promoters: Two interactions between CAP and RNA polymerase, Cell, 87, 1123, 10.1016\u002FS0092-8674(00)81806-1",{"doi":7251},"10.1016\u002FS0092-8674(00)81806-1",{"id":28,"text":7253,"url":28,"identifiers":7254},"Nickels, 2006, RNA-mediated destabilization of the σ70 region 4\u002Fβ flap interaction facilitates engagement of RNA polymerase by the Q antiterminator, Mol. Cell, 24, 457, 10.1016\u002Fj.molcel.2006.09.014",{"doi":7255},"10.1016\u002Fj.molcel.2006.09.014",{"id":28,"text":7257,"url":28,"identifiers":7258},"Mitchell, 2003, Identification and analysis of ‘extended-10’ promoters in Escherichia coli, Nucleic Acids Res., 31, 4689, 10.1093\u002Fnar\u002Fgkg694",{"doi":7259},"10.1093\u002Fnar\u002Fgkg694",{"id":28,"text":7261,"url":28,"identifiers":7262},"Shimada, 2014, The whole set of constitutive promoters recognized by RNA polymerase RpoD holoenzyme of Escherichia coli, PLoS ONE, 9, e90447, 10.1371\u002Fjournal.pone.0090447",{"doi":7263},"10.1371\u002Fjournal.pone.0090447",{"id":28,"text":7265,"url":28,"identifiers":7266},"Aoyama, 1983, Essential structure of E. coli promoter: Effect of spacer length between the two consensus sequences on promoter function, Nucleic Acids Res., 11, 5855, 10.1093\u002Fnar\u002F11.17.5855",{"doi":7267},"10.1093\u002Fnar\u002F11.17.5855",{"id":28,"text":7269,"url":28,"identifiers":7270},"Mulligan, 1985, Characterization in vitro of the effect of spacer length on the activity of Escherichia coli RNA polymerase at the TAC promoter, J. Biol. Chem., 260, 3529, 10.1016\u002FS0021-9258(19)83654-2",{"doi":7271},"10.1016\u002FS0021-9258(19)83654-2",{"id":28,"text":7273,"url":28,"identifiers":7274},"Stefano, 1982, Spacer mutations in the lac ps promoter, Proc. Natl. Acad. Sci. USA, 79, 1069, 10.1073\u002Fpnas.79.4.1069",{"doi":7275},"10.1073\u002Fpnas.79.4.1069",{"id":28,"text":7277,"url":28,"identifiers":7278},"Hinton, 2009, The promoter spacer influences transcription initiation via σ70 region 1.1 of Escherichia coli RNA polymerase, Proc. Natl. Acad. Sci. USA, 106, 737, 10.1073\u002Fpnas.0808133106",{"doi":7279},"10.1073\u002Fpnas.0808133106",{"id":28,"text":7281,"url":28,"identifiers":7282},"Yuzenkova, 2011, A new basal promoter element recognized by RNA polymerase core enzyme, EMBO J., 30, 3766, 10.1038\u002Femboj.2011.252",{"doi":7283},"10.1038\u002Femboj.2011.252",{"id":28,"text":7285,"url":28,"identifiers":7286},"Barne, 1997, Region 2.5 of the Escherichia coli RNA polymerase σ70 subunit is responsible for the recognition of the ‘extended-10’ motif at promoters, EMBO J., 16, 4034, 10.1093\u002Femboj\u002F16.13.4034",{"doi":7287},"10.1093\u002Femboj\u002F16.13.4034",{"id":28,"text":7289,"url":28,"identifiers":7290},"Haugen, 2006, rRNA promoter regulation by nonoptimal binding of sigma region 1.2: An additional recognition element for RNA polymerase, Cell, 125, 1069, 10.1016\u002Fj.cell.2006.04.034",{"doi":7291},"10.1016\u002Fj.cell.2006.04.034",{"id":28,"text":7293,"url":28,"identifiers":7294},"Guo, 2000, Promoter opening by σ54 and σ70 RNA polymerases: σ factor-directed alterations in the mechanism and tightness of control, Genes Dev., 14, 2242, 10.1101\u002Fgad.794800",{"doi":7295},"10.1101\u002Fgad.794800",{"id":28,"text":7297,"url":28,"identifiers":7298},"Waldburger, 1990, Changes in conserved region 2 of Escherichia coli σ70 affecting promoter recognition, J. Mol. Biol., 215, 267, 10.1016\u002FS0022-2836(05)80345-6",{"doi":7299},"10.1016\u002FS0022-2836(05)80345-6",{"id":28,"text":7301,"url":28,"identifiers":7302},"Marr, 1997, Promoter recognition as measured by binding of polymerase to nontemplate strand oligonucleotide, Science, 276, 1258, 10.1126\u002Fscience.276.5316.1258",{"doi":7303},"10.1126\u002Fscience.276.5316.1258",{"id":28,"text":7305,"url":28,"identifiers":7306},"Roberts, 1996, Base-specific recognition of the nontemplate strand of promoter DNA by E. coli RNA polymerase, Cell, 86, 495, 10.1016\u002FS0092-8674(00)80122-1",{"doi":7307},"10.1016\u002FS0092-8674(00)80122-1",{"id":28,"text":7309,"url":28,"identifiers":7310},"Cook, 2007, Strand opening-deficient Escherichia coli RNA polymerase facilitates investigation of closed complexes with promoter DNA: Effects of DNA sequence and temperature, J. Biol. Chem., 282, 21319, 10.1074\u002Fjbc.M702232200",{"doi":7311},"10.1074\u002Fjbc.M702232200",{"id":28,"text":7313,"url":28,"identifiers":7314},"Shultzaberger, 2007, Anatomy of Escherichia coli σ70 promoters, Nucleic Acids Res., 35, 771, 10.1093\u002Fnar\u002Fgkl956",{"doi":7315},"10.1093\u002Fnar\u002Fgkl956",{"id":28,"text":7317,"url":28,"identifiers":7318},"Campagne, 2014, Structural basis for –10 promoter element melting by environmentally induced sigma factors, Nat. Struct. Mol. Biol., 21, 269, 10.1038\u002Fnsmb.2777",{"doi":7319},"10.1038\u002Fnsmb.2777",{"id":28,"text":7321,"url":28,"identifiers":7322},"Haugen, 2008, Fine structure of the promoter-sigma region 1.2 interaction, Proc. Natl. Acad. Sci. USA, 105, 3292, 10.1073\u002Fpnas.0709513105",{"doi":7323},"10.1073\u002Fpnas.0709513105",{"id":28,"text":7325,"url":28,"identifiers":7326},"Jeong, 1994, Start site selection at lacUV5 promoter affected by the sequence context around the initiation sites, Nucleic Acids Res., 22, 4667, 10.1093\u002Fnar\u002F22.22.4667",{"doi":7327},"10.1093\u002Fnar\u002F22.22.4667",{"id":28,"text":7329,"url":28,"identifiers":7330},"Lewis, 2004, Axiom of determining transcription start points by RNA polymerase in Escherichia coli, Mol. Microbiol., 54, 692, 10.1111\u002Fj.1365-2958.2004.04318.x",{"doi":7331},"10.1111\u002Fj.1365-2958.2004.04318.x",{"id":28,"text":7333,"url":28,"identifiers":7334},"Liu, 1994, Effects of transcriptional start site sequence and position on nucleotide-sensitive selection of alternative start sites at the pyrC promoter in Escherichia coli, J. Bacteriol., 176, 2938, 10.1128\u002Fjb.176.10.2938-2945.1994",{"doi":7335},"10.1128\u002Fjb.176.10.2938-2945.1994",{"id":28,"text":7337,"url":28,"identifiers":7338},"1989, Escherichia coli promoters. I. Consensus as it relates to spacing class, specificity, repeat substructure, and three-dimensional organization, J. Biol. Chem., 264, 5522",{},{"id":28,"text":7340,"url":28,"identifiers":7341},"Thomason, 2015, Global transcriptional start site mapping using differential RNA sequencing reveals novel antisense RNAs in Escherichia coli, J. Bacteriol., 197, 18, 10.1128\u002FJB.02096-14",{"doi":7342},"10.1128\u002FJB.02096-14",{"id":28,"text":7344,"url":28,"identifiers":7345},"Feklistov, 2006, A basal promoter element recognized by free RNA polymerase sigma subunit determines promoter recognition by RNA polymerase holoenzyme, Mol. Cell, 23, 97, 10.1016\u002Fj.molcel.2006.06.010",{"doi":7346},"10.1016\u002Fj.molcel.2006.06.010",{"id":28,"text":7348,"url":28,"identifiers":7349},"Travers, 1980, Promoter sequence for stringent control of bacterial ribonucleic acid synthesis, J. Bacteriol., 141, 973, 10.1128\u002Fjb.141.2.973-976.1980",{"doi":7350},"10.1128\u002Fjb.141.2.973-976.1980",{"id":28,"text":7352,"url":28,"identifiers":7353},"Guerin, 1996, High resolution mapping of E.coli transcription elongation complex in situ reveals protein interactions with the non-transcribed strand, EMBO J., 15, 5397, 10.1002\u002Fj.1460-2075.1996.tb00923.x",{"doi":7354},"10.1002\u002Fj.1460-2075.1996.tb00923.x",{"id":28,"text":7356,"url":28,"identifiers":7357},"Vvedenskaya, 2014, Transcription. Interactions between RNA polymerase and the “core recognition element” counteract pausing, Science, 344, 1285, 10.1126\u002Fscience.1253458",{"doi":7358},"10.1126\u002Fscience.1253458",{"id":28,"text":7360,"url":28,"identifiers":7361},"Gaal, 1997, Transcription regulation by initiating NTP concentration: RRNA synthesis in bacteria, Science, 278, 2092, 10.1126\u002Fscience.278.5346.2092",{"doi":7362},"10.1126\u002Fscience.278.5346.2092",{"id":28,"text":7364,"url":28,"identifiers":7365},"Guthold, 1999, Direct observation of one-dimensional diffusion and transcription by Escherichia coli RNA polymerase, Biophys. J., 77, 2284, 10.1016\u002FS0006-3495(99)77067-0",{"doi":7366},"10.1016\u002FS0006-3495(99)77067-0",{"id":28,"text":7368,"url":28,"identifiers":7369},"Harada, 1999, Single-molecule imaging of RNA polymerase-DNA interactions in real time, Biophys. J., 76, 709, 10.1016\u002FS0006-3495(99)77237-1",{"doi":7370},"10.1016\u002FS0006-3495(99)77237-1",{"id":28,"text":7372,"url":28,"identifiers":7373},"Kabata, 1993, Visualization of single molecules of RNA polymerase sliding along DNA, Science, 262, 1561, 10.1126\u002Fscience.8248804",{"doi":7374},"10.1126\u002Fscience.8248804",{"id":28,"text":7376,"url":28,"identifiers":7377},"Ricchetti, 1988, One-dimensional diffusion of Escherichia coli DNA-dependent RNA polymerase: A mechanism to facilitate promoter location, Proc. Natl. Acad. Sci. USA, 85, 4610, 10.1073\u002Fpnas.85.13.4610",{"doi":7378},"10.1073\u002Fpnas.85.13.4610",{"id":28,"text":7380,"url":28,"identifiers":7381},"Singer, 1987, Promoter search by Escherichia coli RNA polymerase on a circular DNA template, J. Biol. Chem., 262, 14178, 10.1016\u002FS0021-9258(18)47921-5",{"doi":7382},"10.1016\u002FS0021-9258(18)47921-5",{"id":28,"text":7384,"url":28,"identifiers":7385},"Friedman, 2013, RNA polymerase approaches its promoter without long-range sliding along DNA, Proc. Natl. Acad. Sci. USA, 110, 9740, 10.1073\u002Fpnas.1300221110",{"doi":7386},"10.1073\u002Fpnas.1300221110",{"id":28,"text":7388,"url":28,"identifiers":7389},"Wang, 2013, The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion, Nat. Struct. Mol. Biol., 20, 174, 10.1038\u002Fnsmb.2472",{"doi":7390},"10.1038\u002Fnsmb.2472",{"id":28,"text":7392,"url":28,"identifiers":7393},"Bakshi, 2013, Partitioning of RNA polymerase activity in live Escherichia coli from analysis of single-molecule diffusive trajectories, Biophys. J., 105, 2676, 10.1016\u002Fj.bpj.2013.10.024",{"doi":7394},"10.1016\u002Fj.bpj.2013.10.024",{"id":28,"text":7396,"url":28,"identifiers":7397},"deHaseth, 1978, Nonspecific interactions of Escherichia coli RNA polymerase with native and denatured DNA: Differences in the binding behavior of core and holoenzyme, Biochemistry, 17, 1612, 10.1021\u002Fbi00602a006",{"doi":7398},"10.1021\u002Fbi00602a006",{"id":28,"text":7400,"url":28,"identifiers":7401},"Hofer, 1985, The pathway of E. coli RNA polymerase-promoter complex formation as visualized by footprinting, Nucleic Acids Res., 13, 5995, 10.1093\u002Fnar\u002F13.16.5995",{"doi":7402},"10.1093\u002Fnar\u002F13.16.5995",{"id":28,"text":7404,"url":28,"identifiers":7405},"Kovacic, 1987, The 0 degree C closed complexes between Escherichia coli RNA polymerase and two promoters, T7-A3 and lacUV5, J. Biol. Chem., 262, 13654, 10.1016\u002FS0021-9258(19)76477-1",{"doi":7406},"10.1016\u002FS0021-9258(19)76477-1",{"id":28,"text":7408,"url":28,"identifiers":7409},"Mecsas, 1991, Development of RNA polymerase-promoter contacts during open complex formation, J. Mol. Biol., 220, 585, 10.1016\u002F0022-2836(91)90102-C",{"doi":7410},"10.1016\u002F0022-2836(91)90102-C",{"id":28,"text":7412,"url":28,"identifiers":7413},"Schickor, 1990, Topography of intermediates in transcription initiation of E. coli, EMBO J., 9, 2215, 10.1002\u002Fj.1460-2075.1990.tb07391.x",{"doi":7414},"10.1002\u002Fj.1460-2075.1990.tb07391.x",{"id":28,"text":7416,"url":28,"identifiers":7417},"Spassky, 1985, Changes in the DNA structure of the lac UV5 promoter during formation of an open complex with Escherichia coli RNA polymerase, Biochemistry, 24, 2723, 10.1021\u002Fbi00332a019",{"doi":7418},"10.1021\u002Fbi00332a019",{"id":28,"text":7420,"url":28,"identifiers":7421},"Ruff, E.F., Zorn, K., Capp, M.W., Artsimovitch, I., and Record, M.T. (2015). Effects of upstream Escherichia coli RNA polymerase-DNA interactions on open complex formation, Unpublished work.",{},{"id":28,"text":7423,"url":28,"identifiers":7424},"Naryshkin, 2000, Structural organization of the RNA polymerase-promoter open complex, Cell, 101, 601, 10.1016\u002FS0092-8674(00)80872-7",{"doi":7425},"10.1016\u002FS0092-8674(00)80872-7",{"id":28,"text":7427,"url":28,"identifiers":7428},"Bartlett, 1998, RNA polymerase mutants that destabilize RNA polymerase-promoter complexes alter NTP-sensing by rrn P1 promoters, J. Mol. Biol., 279, 331, 10.1006\u002Fjmbi.1998.1779",{"doi":7429},"10.1006\u002Fjmbi.1998.1779",{"id":28,"text":7431,"url":28,"identifiers":7432},"Rutherford, 2009, Allosteric control of Escherichia coli rRNA promoter complexes by DksA, Genes Dev., 23, 236, 10.1101\u002Fgad.1745409",{"doi":7433},"10.1101\u002Fgad.1745409",{"id":28,"text":7435,"url":28,"identifiers":7436},"Li, 1998, Characterization of the closed complex intermediate formed during transcription initiation by Escherichia coli RNA polymerase, J. Biol. Chem., 273, 23549, 10.1074\u002Fjbc.273.36.23549",{"doi":7437},"10.1074\u002Fjbc.273.36.23549",{"id":28,"text":7439,"url":28,"identifiers":7440},"Browning, 2004, The regulation of bacterial transcription initiation, Nat. Rev. Microbiol., 2, 57, 10.1038\u002Fnrmicro787",{"doi":7441},"10.1038\u002Fnrmicro787",{"id":28,"text":7443,"url":28,"identifiers":7444},"Drennan, 2012, Key roles of the downstream mobile jaw of Escherichia coli RNA polymerase in transcription initiation, Biochemistry, 51, 9447, 10.1021\u002Fbi301260u",{"doi":7445},"10.1021\u002Fbi301260u",{"id":28,"text":7447,"url":28,"identifiers":7448},"Mekler, 2011, Molecular mechanism of transcription inhibition by phage T7 Gp2 protein, J. Mol. Biol., 413, 1016, 10.1016\u002Fj.jmb.2011.09.029",{"doi":7449},"10.1016\u002Fj.jmb.2011.09.029",{"id":28,"text":7451,"url":28,"identifiers":7452},"Artsimovitch, 2003, Co-overexpression of Escherichia coli RNA polymerase subunits allows isolation and analysis of mutant enzymes lacking lineage-specific sequence insertions, J. Biol. Chem., 278, 12344, 10.1074\u002Fjbc.M211214200",{"doi":7453},"10.1074\u002Fjbc.M211214200",{"id":28,"text":7455,"url":28,"identifiers":7456},"Hawley, D.K., Malan, T.P., Mulligan, M.E., and McClure, W.R. (1982). Promoters: Structure and Function, Praeger.",{},{"id":28,"text":7458,"url":28,"identifiers":7459},"McClure, 1980, Rate-limiting steps in RNA chain initiation, Proc. Natl. Acad. Sci. USA, 77, 5634, 10.1073\u002Fpnas.77.10.5634",{"doi":7460},"10.1073\u002Fpnas.77.10.5634",{"id":28,"text":7462,"url":28,"identifiers":7463},"Tsodikov, 1999, General method of analysis of kinetic equations for multistep reversible mechanisms in the single-exponential regime: Application to kinetics of open complex formation between Eσ70 RNA polymerase and λPR promoter DNA, Biophys. J., 76, 1320, 10.1016\u002FS0006-3495(99)77294-2",{"doi":7464},"10.1016\u002FS0006-3495(99)77294-2",{"id":28,"text":7466,"url":28,"identifiers":7467},"Drennan, A.C. (2012). Key conformational changes of Escherichia coli RNA polymerase and promoter DNA in transcription initiation. [Ph.D. Thesis, University of Wisconsin].",{},{"id":28,"text":7469,"url":28,"identifiers":7470},"Heitkamp, S.E. (2012). Real-Time characterization of transcription initiation intermediates for E. coli RNA polymerase using fast footprinting and equilibrium and stopped-flow fluorescence. [Ph.D. Thesis, University of Wisconsin].",{},{"id":28,"text":7472,"url":28,"identifiers":7473},"Hinton, 2007, Transcription initiation by mix and match elements: Flexibility for polymerase binding to bacterial promoters, Gene Regul. Syst. Biol., 1, 275",{},{"id":7475,"createTime":7476,"updateTime":7476,"relativeEntities":7477,"slug":7478,"properties":7479,"entityType":972,"verifyStatus":26,"verifyTime":7476,"verifyNote":973,"languages":7494,"translateLanguages":28,"viewCount":32,"primaryUrl":7495,"fullTextUrl":28,"authors":7496,"publicationType":1209,"publisherRelationship":7584,"citationCount":7637,"citationInfo":7638,"publishDate":28,"publishYear":28,"citationAnalyzeStatus":881,"lastCitationAnalyze":28,"indexDatabases":7640,"openAccess":28,"references":7641,"isForceReanalyzing":2008},"bf15a0dd-0653-4cb1-9658-62a941288581","2024-10-05T05:26:36.979+00:00",[],"Advanced-Glycation-End-Products-AGEs-May-Be-a-Striking-Link-Between-Modern-Diet-and-Health",{"mag":7480,"pmc":7482,"openalex":7484,"abstract":7486,"title":7488,"pm":7490,"doi":7492},{"VOID":7481},"2995142310",{"VOID":7483},"6995512",{"VOID":7485},"W2995142310",{"EN":7487},"\u003Cjats:p>The Maillard reaction is a simple but ubiquitous reaction that occurs both in vivo and ex vivo during the cooking or processing of foods under high-temperature conditions, such as baking, frying, or grilling. Glycation of proteins is a post-translational modification that forms temporary adducts, which, on further crosslinking and rearrangement, form permanent residues known as advanced glycation end products (AGEs). Cooking at high temperature results in various food products having high levels of AGEs. This review underlines the basis of AGE formation and their corresponding deleterious effects on the body. Glycated Maillard products have a direct association with the pathophysiology of some metabolic diseases, such as diabetes mellitus type 2 (DM2), acute renal failure (ARF), Alzheimer’s disease, dental health, allergies, and polycystic ovary syndrome (PCOS). The most glycated and structurally abundant protein is collagen, which acts as a marker for diabetes and aging, where decreased levels indicate reduced skin elasticity. In diabetes, high levels of AGEs are associated with carotid thickening, ischemic heart disease, uremic cardiomyopathy, and kidney failure. AGEs also mimic hormones or regulate\u002Fmodify their receptor mechanisms at the DNA level. In women, a high AGE diet directly correlates with high levels of androgens, anti-Müllerian hormone, insulin, and androstenedione, promoting ovarian dysfunction and\u002For infertility. Vitamin D3 is well-associated with the pathogenesis of PCOS and modulates steroidogenesis. It also exhibits a protective mechanism against the harmful effects of AGEs. This review elucidates and summarizes the processing of infant formula milk and the associated health hazards. Formulated according to the nutritional requirements of the newborn as a substitute for mother’s milk, formula milk is a rich source of primary adducts, such as carboxy-methyl lysine, which render an infant prone to inflammation, dementia, food allergies, and other diseases. We therefore recommend that understanding this post-translational modification is the key to unlocking the mechanisms and physiology of various metabolic syndromes.\u003C\u002Fjats:p>",{"EN":7489},"Advanced Glycation End Products (AGEs) May Be a Striking Link Between Modern Diet and Health",{"VOID":7491},"31861217",{"VOID":7493},"10.3390\u002Fbiom9120888",[31],"https:\u002F\u002Fwww.mdpi.com\u002F2218-273X\u002F9\u002F12\u002F888",[7497,7514,7533,7548,7567],{"id":7498,"sortIndex":32,"researcher":28,"roles":7499,"affiliations":7500,"properties":7509,"displayName":7511,"givenName":28,"familyName":28},"03a838b7-4355-48b7-896a-fadd279dd335",[],[7501],{"id":7502,"sortIndex":32,"affiliation":7503,"properties":28},"ad6224ca-e98e-4e59-b03e-feddaf11e99a",{"id":7502,"createTime":28,"updateTime":28,"relativeEntities":7504,"slug":28,"properties":7505,"entityType":28,"verifyStatus":28,"verifyTime":28,"verifyNote":28,"languages":28,"translateLanguages":28,"viewCount":28,"url":28,"parentIds":7508,"statistic":28},[],{"title":7506},{"EN":7507},"Central Research Station, Subharti Medical College, Swami Vivekanand Subharti University, Meerut 250002, India",[],{"title":7510,"openalex":7512},{"EN":7511},"V. 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2005, The Maillard Reaction. Chemistry, Biochemistry and Implications. By Harry Nursten, Angew. Int. Ed., 44, 7503, 10.1002\u002Fanie.200585332",{"doi":7645},"10.1002\u002Fanie.200585332",{"id":28,"text":7647,"url":28,"identifiers":7648},"Fogliano, 2018, Dietary Advanced Glycosylation End-Products (dAGEs) and Melanoidins Formed through the Maillard Reaction: Physiological Consequences of their Intake, Annu. Rev. Food Sci. Technol., 9, 271, 10.1146\u002Fannurev-food-030117-012441",{"doi":7649},"10.1146\u002Fannurev-food-030117-012441",{"id":28,"text":7651,"url":28,"identifiers":7652},"Thorpe, 2003, Maillard reaction products in tissue proteins: New products and new perspectives, Amino Acids, 25, 275, 10.1007\u002Fs00726-003-0017-9",{"doi":7653},"10.1007\u002Fs00726-003-0017-9",{"id":28,"text":7655,"url":28,"identifiers":7656},"Munch, 1999, Amino acid specificity of glycation and protein-AGE crosslinking reactivities determined with a dipeptide SPOT library, Nat. Biotechnol., 17, 1006, 10.1038\u002F13704",{"doi":7657},"10.1038\u002F13704",{"id":28,"text":7659,"url":28,"identifiers":7660},"Nowotny, 2018, Dietary advanced glycation end products and their relevance for human health, Ageing Res. Rev., 47, 55, 10.1016\u002Fj.arr.2018.06.005",{"doi":7661},"10.1016\u002Fj.arr.2018.06.005",{"id":28,"text":7663,"url":28,"identifiers":7664},"Vasan, 2003, Therapeutic potential of breakers of advanced glycation end product-protein crosslinks, Arch. Biochem. Biophys., 419, 89, 10.1016\u002Fj.abb.2003.08.016",{"doi":7665},"10.1016\u002Fj.abb.2003.08.016",{"id":28,"text":7667,"url":28,"identifiers":7668},"Ott, 2014, Role of advanced glycation end products in cellular signaling, Redox Biol., 2, 411, 10.1016\u002Fj.redox.2013.12.016",{"doi":7669},"10.1016\u002Fj.redox.2013.12.016",{"id":28,"text":7671,"url":28,"identifiers":7672},"Nass, 2007, Advanced glycation end products, diabetes and ageing, Z. Gerontol. Geriatr., 40, 349, 10.1007\u002Fs00391-007-0484-9",{"doi":7673},"10.1007\u002Fs00391-007-0484-9",{"id":28,"text":7675,"url":28,"identifiers":7676},"Makita, 1992, Immunochemical detection of advanced glycosylation end products in vivo, J. Biol. Chem., 267, 5133, 10.1016\u002FS0021-9258(18)42741-X",{"doi":7677},"10.1016\u002FS0021-9258(18)42741-X",{"id":28,"text":7679,"url":28,"identifiers":7680},"Kasper, 2001, Age-related changes in cells and tissues due to advanced glycation end products (AGEs), Arch. Gerontol. Geriatr., 32, 233, 10.1016\u002FS0167-4943(01)00103-0",{"doi":7681},"10.1016\u002FS0167-4943(01)00103-0",{"id":28,"text":7683,"url":28,"identifiers":7684},"Ko, S.Y., Ko, H.A., Chu, K.H., Shieh, T.M., Chi, T.C., Chen, H.I., Chang, W.C., and Chang, S.S. (2015). The Possible Mechanism of Advanced Glycation End Products (AGEs) for Alzheimer’s Disease. PLoS ONE, 10.",{"doi":7685},"10.1371\u002Fjournal.pone.0143345",{"id":28,"text":7687,"url":28,"identifiers":7688},"Pinkas, 2016, Advanced Glycation End-Products and Their Receptors: Related Pathologies, Recent Therapeutic Strategies, and a Potential Model for Future Neurodegeneration Studies, Chem. Res. Toxicol., 29, 707, 10.1021\u002Facs.chemrestox.6b00034",{"doi":7689},"10.1021\u002Facs.chemrestox.6b00034",{"id":28,"text":7691,"url":28,"identifiers":7692},"Juranek, 2015, Receptor for advanced glycation end-products in neurodegenerative diseases, Rev. Neurosci., 26, 691, 10.1515\u002Frevneuro-2015-0003",{"doi":7693},"10.1515\u002Frevneuro-2015-0003",{"id":28,"text":7695,"url":28,"identifiers":7696},"Ahmed, 2002, Assay of advanced glycation endproducts (AGEs): Surveying AGEs by chromatographic assay with derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and application to Nepsilon-carboxymethyl-lysine-and Nepsilon-(1-carboxyethyl)lysine-modified albumin, Biochem. J., 364, 1, 10.1042\u002Fbj3640001",{"doi":7697},"10.1042\u002Fbj3640001",{"id":28,"text":7699,"url":28,"identifiers":7700},"Ravichandran, 2019, Food advanced glycation end products as potential endocrine disruptors: An emerging threat to contemporary and future generation, Environ. Int., 123, 486, 10.1016\u002Fj.envint.2018.12.032",{"doi":7701},"10.1016\u002Fj.envint.2018.12.032",{"id":28,"text":7703,"url":28,"identifiers":7704},"Rutkowska, 2016, Polycystic ovary syndrome and environmental toxins, Fertil. Steril., 106, 948, 10.1016\u002Fj.fertnstert.2016.08.031",{"doi":7705},"10.1016\u002Fj.fertnstert.2016.08.031",{"id":28,"text":7707,"url":28,"identifiers":7708},"Kutlu, 2016, Dietary glycotoxins and infant formulas, Turk Pediatr., 51, 179, 10.5152\u002FTurkPediatriArs.2016.2543",{"doi":7709},"10.5152\u002FTurkPediatriArs.2016.2543",{"id":28,"text":7711,"url":28,"identifiers":7712},"Nowotny, 2015, Advanced glycation end products and oxidative stress in type 2 diabetes mellitus, Biomolecules, 5, 194, 10.3390\u002Fbiom5010194",{"doi":7713},"10.3390\u002Fbiom5010194",{"id":28,"text":7715,"url":28,"identifiers":7716},"Baye, 2017, Effect of dietary advanced glycation end products on inflammation and cardiovascular risks in healthy overweight adults: A randomised crossover trial, Sci. Rep., 7, 4123, 10.1038\u002Fs41598-017-04214-6",{"doi":7717},"10.1038\u002Fs41598-017-04214-6",{"id":28,"text":7719,"url":28,"identifiers":7720},"Vlassara, 1992, Exogenous advanced glycosylation end products induce complex vascular dysfunction in normal animals: A model for diabetic and aging complications, Proc. Natl. Acad. Sci. USA, 89, 12043, 10.1073\u002Fpnas.89.24.12043",{"doi":7721},"10.1073\u002Fpnas.89.24.12043",{"id":28,"text":7723,"url":28,"identifiers":7724},"Wrobel, 2018, Comparative evaluation of three different ELISA assays and HPLC-ESI-ITMS\u002FMS for the analysis of N(epsilon)-carboxymethyl lysine in food samples, Food Chem., 243, 11, 10.1016\u002Fj.foodchem.2017.09.098",{"doi":7725},"10.1016\u002Fj.foodchem.2017.09.098",{"id":28,"text":7727,"url":28,"identifiers":7728},"Wellner, 2011, Formation of Maillard reaction products during heat treatment of carrots, J. Agric. Food Chem., 59, 7992, 10.1021\u002Fjf2013293",{"doi":7729},"10.1021\u002Fjf2013293",{"id":28,"text":7731,"url":28,"identifiers":7732},"Zhou, 2015, Simultaneous analysis of Nε-(carboxymethyl)Lysine and Nε-(carboxyethyl)lysine in foods by ultra-performance liquid chromatography-mass spectrometry with derivatization by 9-fluorenylmethyl chloroformate, J. Food Sci., 80, C207, 10.1111\u002F1750-3841.12744",{"doi":7733},"10.1111\u002F1750-3841.12744",{"id":28,"text":7735,"url":28,"identifiers":7736},"Zhang, 2003, Rapid determination of advanced glycation end products of proteins using MALDI-TOF-MS and PERL script peptide searching algorithm, J. Biomol. Tech., 14, 224",{},{"id":28,"text":7738,"url":28,"identifiers":7739},"Ahmed, 2005, Advanced glycation endproducts—Role in pathology of diabetic complications, Diabetes Res. Clin. Pract., 67, 3, 10.1016\u002Fj.diabres.2004.09.004",{"doi":7740},"10.1016\u002Fj.diabres.2004.09.004",{"id":28,"text":7742,"url":28,"identifiers":7743},"Paul, 1996, Glycation of collagen: The basis of its central role in the late complications of ageing and diabetes, Int. J. Biochem. Cell Biol., 28, 1297, 10.1016\u002FS1357-2725(96)00079-9",{"doi":7744},"10.1016\u002FS1357-2725(96)00079-9",{"id":28,"text":7746,"url":28,"identifiers":7747},"Uribarri, J. (2018). Dietary AGE and Their Role in Health and Disease, CRCPress.",{"doi":7748},"10.1201\u002F9781315120041",{"id":28,"text":7750,"url":28,"identifiers":7751},"Koschinsky, 1997, Orally absorbed reactive glycation products (glycotoxins): An environmental risk factor in diabetic nephropathy, Proc. Natl. Acad. Sci. USA, 94, 6474, 10.1073\u002Fpnas.94.12.6474",{"doi":7752},"10.1073\u002Fpnas.94.12.6474",{"id":28,"text":7754,"url":28,"identifiers":7755},"Snelson, M., and Coughlan M., T. (2019). Dietary Advanced Glycation End Products: Digestion, Metabolism and Modulation of Gut Microbial Ecology. Nutrients, 11.",{"doi":7756},"10.3390\u002Fnu11020215",{"id":28,"text":7758,"url":28,"identifiers":7759},"2016, Carboxymethyl-lysine: Thirty years of investigation in the field of age formation, Food Funct., 7, 46, 10.1039\u002FC5FO00918A",{"doi":7760},"10.1039\u002FC5FO00918A",{"id":28,"text":7762,"url":28,"identifiers":7763},"Grunwald, 2006, Transepithelial flux of early and advanced glycation compounds across caco-2 cell monolayers and their interaction with intestinal amino acid and peptide transport systems, Br. J. Nutr., 95, 1221, 10.1079\u002FBJN20061793",{"doi":7764},"10.1079\u002FBJN20061793",{"id":28,"text":7766,"url":28,"identifiers":7767},"Hellwig, 2014, N-epsilon-fructosyllysine and n-epsilon-carboxymethyllysine, but not lysinoalanine, are available for absorption after simulated gastrointestinal digestion, Amino Acids., 46, 289, 10.1007\u002Fs00726-013-1501-5",{"doi":7768},"10.1007\u002Fs00726-013-1501-5",{"id":28,"text":7770,"url":28,"identifiers":7771},"Teodorowicz, M., Neerven, J.V., and Savelkoul, H. (2017). Food Processing: The Influence of the Maillard Reaction on Immunogenicity and Allergenicity of Food Proteins. Nutrients, 9.",{"doi":7772},"10.3390\u002Fnu9080835",{"id":28,"text":7774,"url":28,"identifiers":7775},"Bergmann, 2001, Radio fluorination and positron emission tomography (PET) as a new approach to study the in vivo distribution and elimination of the advanced glycation endproducts N-epsilon-carboxymethyllysine (CML) and N-epsilon-carboxyethyllysine (CEL)and N epsilon-carboxyethyllysine (CEL), Nahrung, 45, 182, 10.1002\u002F1521-3803(20010601)45:3\u003C182::AID-FOOD182>3.0.CO;2-Q",{"doi":7776},"10.1002\u002F1521-3803(20010601)45:3\u003C182::AID-FOOD182>3.0.CO;2-Q",{"id":28,"text":7778,"url":28,"identifiers":7779},"He, 1999, Dietary glycotoxins: Inhibition of reactive products by aminoguanidine facilitates renal clearance and reduces tissue sequestration, Diabetes, 48, 1308, 10.2337\u002Fdiabetes.48.6.1308",{"doi":7780},"10.2337\u002Fdiabetes.48.6.1308",{"id":28,"text":7782,"url":28,"identifiers":7783},"Poulsen, 2013, Advanced glycation endproducts in food and their effects on health, Food Chem. Toxicol., 60, 10, 10.1016\u002Fj.fct.2013.06.052",{"doi":7784},"10.1016\u002Fj.fct.2013.06.052",{"id":28,"text":7786,"url":28,"identifiers":7787},"Guilbaud, A., Niquet-Leridon, C., Boulanger, E., and Tessier, F.J. (2016). How Can Diet Affect the Accumulation of Advanced Glycation End-Products in the Human Body?. Foods, 5.",{"doi":7788},"10.3390\u002Ffoods5040084",{"id":28,"text":7790,"url":28,"identifiers":7791},"Uribarri, 2010, Advanced glycation end products in foods and a practical guide to their reduction in the diet, J. Am. Diet. Assoc., 110, 911, 10.1016\u002Fj.jada.2010.03.018",{"doi":7792},"10.1016\u002Fj.jada.2010.03.018",{"id":28,"text":7794,"url":28,"identifiers":7795},"Uribarri, 2015, Dietary advanced glycation end products and their role in health and disease, Adv. Nutr., 6, 461, 10.3945\u002Fan.115.008433",{"doi":7796},"10.3945\u002Fan.115.008433",{"id":28,"text":7798,"url":28,"identifiers":7799},"Henle, 2007, Dietary advanced glycation end products—A risk to human health? A call for an interdisciplinary debate, Mol. Nutr. Food Res., 51, 1075, 10.1002\u002Fmnfr.200700067",{"doi":7800},"10.1002\u002Fmnfr.200700067",{"id":28,"text":7802,"url":28,"identifiers":7803},"Cai, 2014, Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans, Proc. Natl. Acad. Sci. USA, 111, 4940, 10.1073\u002Fpnas.1316013111",{"doi":7804},"10.1073\u002Fpnas.1316013111",{"id":28,"text":7806,"url":28,"identifiers":7807},"Fishman, 2018, The role of advanced glycation end-products in the development of coronary artery disease in patients with and without diabetes mellitus: A review, Mol. Med., 24, 59, 10.1186\u002Fs10020-018-0060-3",{"doi":7808},"10.1186\u002Fs10020-018-0060-3",{"id":28,"text":7810,"url":28,"identifiers":7811},"Davis, 2016, Advanced Glycation End Products, Inflammation, and Chronic Metabolic Diseases: Links in a Chain?, Crit. Rev. Food Sci. Nutr., 56, 989, 10.1080\u002F10408398.2012.744738",{"doi":7812},"10.1080\u002F10408398.2012.744738",{"id":28,"text":7814,"url":28,"identifiers":7815},"Li, 2012, Advanced glycation end products and neurodegenerative diseases: Mechanisms and perspective, J. Neurol. Sci., 317, 1, 10.1016\u002Fj.jns.2012.02.018",{"doi":7816},"10.1016\u002Fj.jns.2012.02.018",{"id":28,"text":7818,"url":28,"identifiers":7819},"Yamagishi, 2016, Pathologic role of dietary advanced glycation end products in cardiometabolic disorders, and therapeutic intervention, Nutrition, 32, 157, 10.1016\u002Fj.nut.2015.08.001",{"doi":7820},"10.1016\u002Fj.nut.2015.08.001",{"id":28,"text":7822,"url":28,"identifiers":7823},"Illien-Junger, S., Lu, Y., Qureshi, S.A., Hecht, A.C., Cai, W., Vlassara, H., Striker, G.E., and Iatridis, J.C. (2015). Chronic ingestion of advanced glycation end products induces degenerative spinal changes and hypertrophy in aging pre-diabetic mice. PLoS ONE, 10.",{"doi":7824},"10.1371\u002Fjournal.pone.0116625",{"id":28,"text":7826,"url":28,"identifiers":7827},"Magalhaes, 2008, Involvement of advanced glycation end products in the pathogenesis of diabetic complications: The protective role of regular physical activity, Eur. Rev. Aging Phys. Act., 5, 17, 10.1007\u002Fs11556-008-0032-7",{"doi":7828},"10.1007\u002Fs11556-008-0032-7",{"id":28,"text":7830,"url":28,"identifiers":7831},"Lo, 2008, Reactive dicarbonyl compounds and 5-(hydroxymethyl)-2-furfural in carbonated beverages containing high fructose corn syrup, Food Chem., 107, 1099, 10.1016\u002Fj.foodchem.2007.09.028",{"doi":7832},"10.1016\u002Fj.foodchem.2007.09.028",{"id":28,"text":7834,"url":28,"identifiers":7835},"Degen, 2012, 1,2-dicarbonyl compounds in commonly consumed foods, J. Agric. Food Chem., 60, 7071, 10.1021\u002Fjf301306g",{"doi":7836},"10.1021\u002Fjf301306g",{"id":28,"text":7838,"url":28,"identifiers":7839},"EFSA (European food safety authority) (2012). Update on acrylamide levels in food from monitoring years 2007–2010. EFSA J., 10, 2938–2976.",{"doi":7840},"10.2903\u002Fj.efsa.2012.2938",{"id":28,"text":7842,"url":28,"identifiers":7843},"Mariotti, 2013, Are Chileans exposed to dietary furan?, Food Addit. Contam. Part A, 10, 1715, 10.1080\u002F19440049.2013.815807",{"doi":7844},"10.1080\u002F19440049.2013.815807",{"id":28,"text":7846,"url":28,"identifiers":7847},"Aguirre, D.B., Corradini, M.G., Candogan, K., and Barbosa-Canovas, G.V. (2016). High pressure processing in combination with high temperature and other preservation factors. High Pressure Processing of Food, Springer.",{"doi":7848},"10.1007\u002F978-1-4939-3234-4_11",{"id":28,"text":7850,"url":28,"identifiers":7851},"1997, Determination of free and total furfural compounds in infant milk formulas by high-performance liquid chromatography, J. Agric. Food Chem., 45, 2128, 10.1021\u002Fjf960770n",{"doi":7852},"10.1021\u002Fjf960770n",{"id":28,"text":7854,"url":28,"identifiers":7855},"Prosser, 2019, N(epsilon)-carboxymethyllysine in nutritional milk formulas for infants, Food Chem., 274, 886, 10.1016\u002Fj.foodchem.2018.09.069",{"doi":7856},"10.1016\u002Fj.foodchem.2018.09.069",{"id":28,"text":7858,"url":28,"identifiers":7859},"Samson, 2014, Metabolic syndrome, Endocrinol. Metab. Clin. N. Am., 43, 1, 10.1016\u002Fj.ecl.2013.09.009",{"doi":7860},"10.1016\u002Fj.ecl.2013.09.009",{"id":28,"text":7862,"url":28,"identifiers":7863},"Han, 2017, Long-term and late treatment consequences: Endocrine and metabolic effects, Curr. Opin. Support Palliat. Care, 11, 205, 10.1097\u002FSPC.0000000000000289",{"doi":7864},"10.1097\u002FSPC.0000000000000289",{"id":28,"text":7866,"url":28,"identifiers":7867},"Gupta, 2016, Dietary Advanced Glycation End Products and Their Potential Role in Cardiometabolic Disease in Children, Horm. Res. Paediatr., 85, 291, 10.1159\u002F000444053",{"doi":7868},"10.1159\u002F000444053",{"id":28,"text":7870,"url":28,"identifiers":7871},"Hsu, 2019, Protein Glycation by glyoxal promotes amyloid formation by islets amyloid polypeptide, Biophys. J., 116, 2304, 10.1016\u002Fj.bpj.2019.05.013",{"doi":7872},"10.1016\u002Fj.bpj.2019.05.013",{"id":28,"text":7874,"url":28,"identifiers":7875},"Hanyu, 2019, Diabetes –related Dementia, Diabetes Mellit., 1128, 147, 10.1007\u002F978-981-13-3540-2_8",{"doi":7876},"10.1007\u002F978-981-13-3540-2_8",{"id":28,"text":7878,"url":28,"identifiers":7879},"Chou, P.S., Wu, M.N., Yang, C.C., Shen, C.T., and Yang, Y.H. (2019). Effect of advanced glycation end products on the progression of Alzheimer’s disease. J. Alzheimers Dis.",{"doi":7880},"10.3233\u002FJAD-190639",{"id":28,"text":7882,"url":28,"identifiers":7883},"Kouidrat, 2015, Advanced glycation end products and schizophrenia: A systematic review, J Psychiatr. Res., 66, 112, 10.1016\u002Fj.jpsychires.2015.04.023",{"doi":7884},"10.1016\u002Fj.jpsychires.2015.04.023",{"id":28,"text":7886,"url":28,"identifiers":7887},"Clatici, 2017, Glycation: Implication in perceived age and dermatology, Rom. J. Clin. Experi. Dermatol., 4, 114",{},{"id":28,"text":7889,"url":28,"identifiers":7890},"Kirstein, 1990, Advanced protein glycosylation induces transendothelial human monocyte chemotaxis and secretion of platelet-derived growth factor: Role in vascular disease of diabetes and aging, Proc. Natl. Acad. Sci. USA, 87, 9010, 10.1073\u002Fpnas.87.22.9010",{"doi":7891},"10.1073\u002Fpnas.87.22.9010",{"id":28,"text":7893,"url":28,"identifiers":7894},"Pehrsson, 1984, Cardiac performance in various stages of renal failure, Br. Heart J., 52, 667, 10.1136\u002Fhrt.52.6.667",{"doi":7895},"10.1136\u002Fhrt.52.6.667",{"id":28,"text":7897,"url":28,"identifiers":7898},"Gyurászová, M., Kovalčíková, A.G., Renczés, E., Kmeťová, K., Celec, P., Bábíčková, J., and Tóthová, L. (2019). Oxidative Stress in Animal Models of Acute and Chronic Renal Failure. Dis. Markers.",{"doi":7899},"10.1155\u002F2019\u002F8690805",{"id":28,"text":7901,"url":28,"identifiers":7902},"Stevenson, 2006, Retinopathy Is Reduced during Experimental Diabetes in a Mouse Model of Outer Retinal Degeneration, Investig. Ophthalmol. Vis. Sci., 47, 5561, 10.1167\u002Fiovs.06-0647",{"doi":7903},"10.1167\u002Fiovs.06-0647",{"id":28,"text":7905,"url":28,"identifiers":7906},"Uchiki, 2012, Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in non diabetics), Aging Cell, 11, 1, 10.1111\u002Fj.1474-9726.2011.00752.x",{"doi":7907},"10.1111\u002Fj.1474-9726.2011.00752.x",{"id":28,"text":7909,"url":28,"identifiers":7910},"Hegab, 2012, Role of advanced glycation end products in cardiovascular disease, World J. Cardiol., 4, 90, 10.4330\u002Fwjc.v4.i4.90",{"doi":7911},"10.4330\u002Fwjc.v4.i4.90",{"id":28,"text":7913,"url":28,"identifiers":7914},"Gkogkolou, 2012, Advanced glycation end products: Key players in skin aging?, Derm. Endocrinol., 3, 259, 10.4161\u002Fderm.22028",{"doi":7915},"10.4161\u002Fderm.22028",{"id":28,"text":7917,"url":28,"identifiers":7918},"Sell, 1990, End-stage renal disease and diabetes catalyze the formation of a pentose-derived crosslink from aging human collagen, J. Clin. Investig., 85, 380, 10.1172\u002FJCI114449",{"doi":7919},"10.1172\u002FJCI114449",{"id":28,"text":7921,"url":28,"identifiers":7922},"Chatzigeorgiou, 2013, Dietary glycotoxins affect scavenger receptor expression and the hormonal profile of female rats, J. Endocrinol., 218, 331, 10.1530\u002FJOE-13-0175",{"doi":7923},"10.1530\u002FJOE-13-0175",{"id":28,"text":7925,"url":28,"identifiers":7926},"Mondal, 2018, Biochemical scenario behind initiation of diabetic retinopathy in type 2 diabetes mellitus, Indian J. Ophthalmol., 66, 535, 10.4103\u002Fijo.IJO_1121_17",{"doi":7927},"10.4103\u002Fijo.IJO_1121_17",{"id":28,"text":7929,"url":28,"identifiers":7930},"Bucala, 1994, Modification of low density lipoprotein by advanced glycation end products contributes to the dyslipidemia of diabetes and renal insufficiency, Proc. Natl. Acad. Sci. USA, 91, 9441, 10.1073\u002Fpnas.91.20.9441",{"doi":7931},"10.1073\u002Fpnas.91.20.9441",{"id":28,"text":7933,"url":28,"identifiers":7934},"Rhee, 2018, The Role of Advanced Glycation End Products in Diabetic Vascular Complications, Diabetes Metab. J., 42, 188, 10.4093\u002Fdmj.2017.0105",{"doi":7935},"10.4093\u002Fdmj.2017.0105",{"id":28,"text":7937,"url":28,"identifiers":7938},"Smith, 2017, The false alarm hypothesis: Food allergy is associated with high dietary advanced glycation end-products and proglycating dietary sugars that mimic alarmins, J. Allergy Clin. Immunol., 139, 429, 10.1016\u002Fj.jaci.2016.05.040",{"doi":7939},"10.1016\u002Fj.jaci.2016.05.040",{"id":28,"text":7941,"url":28,"identifiers":7942},"Smith, 2017, Do advanced glycation end-products cause food allergy?, Curr. Opin. Allergy Clin. Immunol., 17, 325, 10.1097\u002FACI.0000000000000385",{"doi":7943},"10.1097\u002FACI.0000000000000385",{"id":28,"text":7945,"url":28,"identifiers":7946},"Forbes, 2005, Below the radar: Advanced glycation end products that detour “around the side”. Is HbA1c not an accurate enough predictor of long term progression and glycaemic control in diabetes?, Clin. Biochem. Rev., 26, 123",{},{"id":28,"text":7948,"url":28,"identifiers":7949},"Dozio, 2017, Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation, Mediat. Inflamm., 2017, 9845175, 10.1155\u002F2017\u002F9845175",{"doi":7950},"10.1155\u002F2017\u002F9845175",{"id":28,"text":7952,"url":28,"identifiers":7953},"Kanda, 2017, Advanced glycation endproducts link inflammatory cues to upregulation of galectin-1 in diabetic retinopathy, Sci. Rep., 7, 16168, 10.1038\u002Fs41598-017-16499-8",{"doi":7954},"10.1038\u002Fs41598-017-16499-8",{"id":28,"text":7956,"url":28,"identifiers":7957},"Wada, 2005, Role of advanced glycation end products and their receptors in development of diabetic neuropathy, Ann. N. Y. Acad. Sci., 1043, 598, 10.1196\u002Fannals.1338.067",{"doi":7958},"10.1196\u002Fannals.1338.067",{"id":28,"text":7960,"url":28,"identifiers":7961},"Normand, 2018, AGE Content of a Protein Load Is Responsible for Renal Performances: A Pilot Study, Diabetes Care, 41, 1292, 10.2337\u002Fdc18-0131",{"doi":7962},"10.2337\u002Fdc18-0131",{"id":28,"text":7964,"url":28,"identifiers":7965},"Nakashima, 2014, Linagliptin blocks renal damage in type 1 diabetic rats by suppressing advanced glycation end products-receptor axis, Horm. Metab. Res., 46, 717, 10.1055\u002Fs-0034-1371892",{"doi":7966},"10.1055\u002Fs-0034-1371892",{"id":28,"text":7968,"url":28,"identifiers":7969},"Nakamura, 1993, Immunohistochemical localization of advanced glycosylation end products in coronary atheroma and cardiac tissue in diabetes mellitus, Am. J. Pathol., 143, 1649",{},{"id":28,"text":7971,"url":28,"identifiers":7972},"Manicam, 2017, Compensatory Vasodilator Mechanisms in the Ophthalmic Artery of Endothelial Nitric Oxide Synthase Gene Knockout Mice, Sci. Rep., 7, 7111, 10.1038\u002Fs41598-017-07768-7",{"doi":7973},"10.1038\u002Fs41598-017-07768-7",{"id":28,"text":7975,"url":28,"identifiers":7976},"Bucala, 1993, Lipid advanced glycosylation: Pathway for lipid oxidation in vivo, Proc. Natl. Acad. Sci. USA, 90, 6434, 10.1073\u002Fpnas.90.14.6434",{"doi":7977},"10.1073\u002Fpnas.90.14.6434",{"id":28,"text":7979,"url":28,"identifiers":7980},"Teissier, 2019, Knockout of receptor for advanced glycation end-products attenuates age-related renal lesions, Aging Cell, 18, e12850, 10.1111\u002Facel.12850",{"doi":7981},"10.1111\u002Facel.12850",{"id":28,"text":7983,"url":28,"identifiers":7984},"Vitek, 1994, Advanced glycation end products contribute to amyloidosis in Alzheimer disease, Proc. Natl. Acad. Sci. USA, 91, 4766, 10.1073\u002Fpnas.91.11.4766",{"doi":7985},"10.1073\u002Fpnas.91.11.4766",{"id":28,"text":7987,"url":28,"identifiers":7988},"Rutkowska, 2016, Do Advanced Glycation End Products (AGEs) Contribute to the Comorbidities of Polycystic Ovary Syndrome (PCOS)?, Curr. Pharm. Des., 22, 5558, 10.2174\u002F1381612822666160714094404",{"doi":7989},"10.2174\u002F1381612822666160714094404",{"id":28,"text":7991,"url":28,"identifiers":7992},"Katsikis, 2008, Increased serum advanced glycation end-products is a distinct finding in lean women with polycystic ovary syndrome (PCOS), Clin. Endocrinol., 69, 634, 10.1111\u002Fj.1365-2265.2008.03247.x",{"doi":7993},"10.1111\u002Fj.1365-2265.2008.03247.x",{"id":28,"text":7995,"url":28,"identifiers":7996},"Garg, 2016, Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS, Reprod. Biol. Endocrinol., 14, 71, 10.1186\u002Fs12958-016-0205-6",{"doi":7997},"10.1186\u002Fs12958-016-0205-6",{"id":28,"text":7999,"url":28,"identifiers":8000},"Tantalaki, 2014, Impact of dietary modification of advanced glycation end products (AGEs) on the hormonal and metabolic profile of women with polycystic ovary syndrome (PCOS), Hormones, 13, 65, 10.1007\u002FBF03401321",{"doi":8001},"10.1007\u002FBF03401321",{"id":28,"text":8003,"url":28,"identifiers":8004},"Merhi, 2019, Implications and Future Perspectives of AGEs in PCOS Pathophysiology, Trends Endocrinol. Metab., 30, 150, 10.1016\u002Fj.tem.2019.01.005",{"doi":8005},"10.1016\u002Fj.tem.2019.01.005",{"id":28,"text":8007,"url":28,"identifiers":8008},"Lin, P.H., Chang, C.C., Wu, K.H., Shih, C.K., Chiang, W., Chen, H.Y., Shih, Y.H., Wang, K.L., Hong, Y.H., and Shieh, T.M. (2019). Dietary Glycotoxins, Advanced Glycation End Products, Inhibit Cell Proliferation and Progesterone Secretion in Ovarian Granulosa Cells and Mimic PCOS-like Symptoms. Biomolecules, 9.",{"doi":8009},"10.3390\u002Fbiom9080327",{"id":28,"text":8011,"url":28,"identifiers":8012},"Liao, 2017, An inverse association between serum soluble receptor of advanced glycation end products and hyperandrogenism and potential implication in polycystic ovary syndrome patients, Reprod. Biol. Endocrinol., 15, 1, 10.1186\u002Fs12958-017-0227-8",{"doi":8013},"10.1186\u002Fs12958-017-0227-8",{"id":28,"text":8015,"url":28,"identifiers":8016},"Lambrinoudaki, 2010, Androgens associated with advanced glycation end-products in postmenopausal women, Menopause, 17, 1182, 10.1097\u002Fgme.0b013e3181e170af",{"doi":8017},"10.1097\u002Fgme.0b013e3181e170af",{"id":28,"text":8019,"url":28,"identifiers":8020},"Li, 2005, Clinical features, hormonal profile, and metabolic abnormalities of obese women with obese polycystic ovary syndrome, Zhonghua Yi Xue Za Zhi, 85, 3266",{},{"id":28,"text":8022,"url":28,"identifiers":8023},"Stracquadanio, 2018, Relationship between serum anti-Mullerian hormone and intrafollicular AMH levels in PCOS women, Gynecol. Endocrinol., 34, 223, 10.1080\u002F09513590.2017.1381838",{"doi":8024},"10.1080\u002F09513590.2017.1381838",{"id":28,"text":8026,"url":28,"identifiers":8027},"Papachroni, 2010, Lysyl oxidase interacts with AGE signalling to modulate collagen synthesis in polycystic ovarian tissue, J. Cell. Mol. Med., 14, 2460, 10.1111\u002Fj.1582-4934.2009.00841.x",{"doi":8028},"10.1111\u002Fj.1582-4934.2009.00841.x",{"id":28,"text":8030,"url":28,"identifiers":8031},"Graff, 2013, Dietary glycemic index is associated with less favorable anthropometric and metabolic profiles in polycystic ovary syndrome women with different phenotypes, Fertil. Sterl., 100, 1081, 10.1016\u002Fj.fertnstert.2013.06.005",{"doi":8032},"10.1016\u002Fj.fertnstert.2013.06.005",{"id":28,"text":8034,"url":28,"identifiers":8035},"Irani, 2014, Role of vitamin D in ovarian physiology and its implications in reproduction: A systematic review, Fertil. Sterl., 102, 460, 10.1016\u002Fj.fertnstert.2014.04.046",{"doi":8036},"10.1016\u002Fj.fertnstert.2014.04.046",{"id":28,"text":8038,"url":28,"identifiers":8039},"Masjedi, 2019, Effects of vitamin D on steoidogenesis, reactive oxygen species production, and enzymatic antioxidant defense in human granulose cells of normal and polycystic ovaries, J. Steroid Biochem. Mol. Biol., 197, 105521, 10.1016\u002Fj.jsbmb.2019.105521",{"doi":8040},"10.1016\u002Fj.jsbmb.2019.105521",{"id":28,"text":8042,"url":28,"identifiers":8043},"Endo, 2006, Significance of matrix metalloproteinases in pathophysiology of the ovary and uterus, Reprod. Med. Biol., 5, 235, 10.1111\u002Fj.1447-0578.2006.00147.x",{"doi":8044},"10.1111\u002Fj.1447-0578.2006.00147.x",{"id":28,"text":8046,"url":28,"identifiers":8047},"Merhi, 2019, Vitamin D attenuates the effect of advanced glycation end products on anti-Mullerian hormone signaling, Mol. Cell.  Endocrinol., 479, 87, 10.1016\u002Fj.mce.2018.09.004",{"doi":8048},"10.1016\u002Fj.mce.2018.09.004",{"id":28,"text":8050,"url":28,"identifiers":8051},"Henmi, H., Endo, T., Nagasawa, K., Hayashi, T., Chida, M., Akutagawa, N., Iwasaki, M., Kitajima, Y., Kiya, T., and Nishikawa, A. (2001). Lysyl oxidase and MMP-2 expression in dehydorepiandrosterone-induces polycystic ovary in rats. Biology of Reproduction. 64, 157–162.",{"doi":8052},"10.1095\u002Fbiolreprod64.1.157",{"id":28,"text":8054,"url":28,"identifiers":8055},"Christakou, 2014, Polycystic ovary syndrome-phenotype and diagnosis. Scandinavian journal of clinical and laboratory investigation, Supplementum, 244, 18",{},{"id":28,"text":8057,"url":28,"identifiers":8058},"Livadas, 2013, Polycystic ovary syndrome: Definitions, phenotypes and diagnostic approach, Front. Horm. Res., 40, 1, 10.1159\u002F000341673",{"doi":8059},"10.1159\u002F000341673",{"id":28,"text":8061,"url":28,"identifiers":8062},"Macut, D., Mladenovic, V., Bjekic-Macut, J., Livadas, S., Stanojlovic, O., Hrncic, D., Rasic-Markovic, A., Milutinovic, D.V., and Andric, Z. (2019). Hypertension in polycystic ovary syndrome: Novel insights. Curr. Hypertens. Rev.",{},{"id":28,"text":8064,"url":28,"identifiers":8065},"Merhi, 2018, Advanced glycation end products alter steroidogenic gene expression by granulosa cells: An effect partially reversible by vitamin D, Mol. Hum. Reprod., 24, 318, 10.1093\u002Fmolehr\u002Fgay014",{"doi":8066},"10.1093\u002Fmolehr\u002Fgay014",{"id":28,"text":8068,"url":28,"identifiers":8069},"Piperi, 2006, Short-term effect of orlistat on dietary glycotoxins in healthy women and women with polycystic ovary syndrome, Metab. Clin. Exp., 55, 494, 10.1016\u002Fj.metabol.2005.10.011",{"doi":8070},"10.1016\u002Fj.metabol.2005.10.011",{"id":28,"text":8072,"url":28,"identifiers":8073},"Piperi, 2007, Accumulation of dietary glycotoxins in the reproductive system of normal female rats, J. Mol. Med., 85, 1413, 10.1007\u002Fs00109-007-0246-6",{"doi":8074},"10.1007\u002Fs00109-007-0246-6",{"id":28,"text":8076,"url":28,"identifiers":8077},"Merhi, 2019, Crosstalk between advanced glycation end products and vitamin D: A compelling paradigm for the treatment of ovarian dysfunction in PCOS, Mol. Cell. Endocrinol., 479, 20, 10.1016\u002Fj.mce.2018.08.010",{"doi":8078},"10.1016\u002Fj.mce.2018.08.010",{"id":28,"text":8080,"url":28,"identifiers":8081},"Koenders, 2018, Vitamin D and metabolic disturbances in polycystic ovary syndrome (PCOS): A cross-sectional study, PLoS ONE, 13, e0204748, 10.1371\u002Fjournal.pone.0204748",{"doi":8082},"10.1371\u002Fjournal.pone.0204748",{"id":28,"text":8084,"url":28,"identifiers":8085},"Lin, 2015, The role of vitamin D in polycystic ovary syndrome, Indian J. Med. Res., 142, 238, 10.4103\u002F0971-5916.166527",{"doi":8086},"10.4103\u002F0971-5916.166527",{"id":28,"text":8088,"url":28,"identifiers":8089},"Heilmann, 2014, Ovalbumin modified with pyrraline, a Maillard reaction product, shows enhanced T-cell immunogenicity, J. Biol. Chem., 289, 7919, 10.1074\u002Fjbc.M113.523621",{"doi":8090},"10.1074\u002Fjbc.M113.523621",{"id":28,"text":8092,"url":28,"identifiers":8093},"Kellow, 2015, Effect of diet-derived advanced glycation end products on inflammation, Nutr. Rev., 73, 737, 10.1093\u002Fnutrit\u002Fnuv030",{"doi":8094},"10.1093\u002Fnutrit\u002Fnuv030",{"id":28,"text":8096,"url":28,"identifiers":8097},"Akram, Z., Alqahtani, F., Alqahtani, M., Al-Kheraif, A.A., and Javed, F. (2019). Levels of advanced glycation end products in gingival crevicular fluid of chronic periodontitis patients with and without type-2 diabetes mellitus. J. Periodontol.",{"doi":8098},"10.1002\u002FJPER.19-0209"]