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Fifty‐six men discontinued TRT due to increasing PSA levels, and 59% of these men had significant reductions in PSA level with no additional intervention. In all, 31 men remain on TRT with no PSA or radiological progression at a median of 36.7 months; nine men stopped TRT for reasons other than progression. Characteristics associated with continuing TRT were radical prostatectomy as primary management, a low PSA level when starting TRT, and concurrent use of dutasteride. Hypogonadal symptoms were alleviated in most cases.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>CONCLUSIONS\u003C\u002Fjats:title>\u003Cjats:p>While most men in this series had increasing PSA levels during TRT, stopping TRT typically resulted in PSA declines. A subset of men were able to remain on TRT for several years without disease progression.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":110},"Testosterone replacement in prostate cancer survivors with hypogonadal symptoms",{"VOID":112},"19912179",{"VOID":114},"10.1111\u002Fj.1464-410x.2009.08980.x","PUBLICATION","VERIFIED","Auto Verify",[119],"EN","https:\u002F\u002Fbjui-journals.onlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1464-410X.2009.08980.x",[122,139,156,178,198],{"id":123,"sortIndex":25,"researcher":24,"roles":124,"affiliations":125,"properties":134,"displayName":136,"givenName":24,"familyName":24},"e87802bf-8566-4e3f-a1e0-7159deb1eb58",[],[126],{"id":127,"sortIndex":25,"affiliation":128,"properties":24},"ed490e80-77d5-4b5b-9606-7ddbfda102d3",{"id":127,"createTime":24,"updateTime":24,"relativeEntities":129,"slug":24,"properties":130,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":133,"statistic":24},[],{"title":131},{"EN":132},"Compassionate Oncology Medical Group, University of Southern California, Los Angeles CA, USA,",[],{"title":135,"openalex":137},{"EN":136},"Robert L. 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We searched published reports in major urological meeting abstracts, Embase and Medline (1966 to 25 August 2008), with no language restrictions. Keyword searches included: ‘scarless’, ‘scar free’, ‘single port\u002Ftrocar\u002Fincision’, ‘intraumbilical’, and ‘transumbilical’, ‘natural orifice transluminal endoscopic surgery’ (NOTES), ‘SILS’, ‘OPUS’ and ‘\u003Cjats:italic>LESS\u003C\u002Fjats:italic>’. The lessons learnt from the studies using the porcine model are that further advances in instrumentation are essential to achieve optimum results, and that testing survival in animals is also necessary to further expand the NOTES and \u003Cjats:italic>LESS\u003C\u002Fjats:italic> techniques. Further advances in instrument technology together with increasing experience in NOTES and \u003Cjats:italic>LESS\u003C\u002Fjats:italic> approaches have driven the transition from porcine models to human patients. In the latter, studies show that the techniques are feasible provided that both optimal surgical technical expertise with advanced skills, and optimal instrumentation, are available. 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SooriakumaranP EdenCG RanéA.Minimal access minimally invasive urological surgery – the new paradigm.BJU Int2008;102:921–2",{"doi":544},"10.1111\u002Fj.1464-410X.2008.07918.x",{"id":546,"createTime":547,"updateTime":548,"relativeEntities":549,"slug":550,"properties":551,"entityType":115,"verifyStatus":116,"verifyTime":547,"verifyNote":117,"languages":566,"translateLanguages":24,"viewCount":25,"primaryUrl":567,"fullTextUrl":24,"authors":568,"publicationType":218,"publisherRelationship":639,"citationCount":25,"citationInfo":690,"publishDate":693,"publishYear":691,"citationAnalyzeStatus":23,"lastCitationAnalyze":694,"indexDatabases":695,"openAccess":24,"references":696,"isForceReanalyzing":363},"1c522769-8076-47c0-8045-c3e3b8432762","2024-09-26T01:41:41.346+00:00","2026-04-01T06:16:21.737+00:00",[],"Thulium-laser-resection-via-a-flexible-cystoscope-for-recurrent-non-muscle-invasive-bladder-cancer-initial-clinical-experience",{"mag":552,"gsPaper":554,"openalex":556,"abstract":558,"title":560,"pm":562,"doi":564},{"VOID":553},"2044317127",{"VOID":555},"[\"16181156014422155087\"]",{"VOID":557},"W2044317127",{"EN":559},"\u003Cjats:sec>\u003Cjats:title>OBJECTIVE\u003C\u002Fjats:title>\u003Cjats:p>To present our initial experience of thulium laser resection via a flexible cystoscope for recurrent non‐muscle‐invasive bladder cancer (ThuRBT), as transurethral resection for bladder tumour (TURBT) is regarded as the reference standard for treating this disease, but alternative laser resection or ablation is suitable especially for recurrent tumours.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>PATIENTS AND METHODS\u003C\u002Fjats:title>\u003Cjats:p>From January 2005 to October 2005, 32 patients with early recurrent bladder tumour (recurrent within a year after TURBT) were treated with ThuRBT via a flexible cystoscope. The follow‐up included urine analysis, ultrasonography and cystoscopy every 3 months.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>RESULTS\u003C\u002Fjats:title>\u003Cjats:p>All patients were treated successfully with ThuRBT in one session, with no bladder haemorrhage, obturator nerve reflex or vesicle perforation. Randomized biopsies taken after surgery on and adjacent to the resection surface revealed no residual tumours. The mean (range) tumour diameter was 1.5 (0.5–3) cm and the mean operative duration was 25 (15–35) min. During the first year of follow‐up, local and heterotopic recurrences were found in three and six patients, respectively. The accumulated recurrence rates at 3, 6 and 12 months were 9%, 22% and 28%, respectively.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>CONCLUSIONS\u003C\u002Fjats:title>\u003Cjats:p>ThuRBT is a reliable therapy with minimal morbidity and invasiveness for selected patients with bladder cancer.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":561},"Thulium laser resection via a flexible cystoscope for recurrent non‐muscle‐invasive bladder cancer: initial clinical 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RZ, 1992, Transcanalicular THC:YAG dacryocystorhinostomy, Ophthalmic Surg, 23, 351",{},{"id":24,"text":746,"url":24,"identifiers":747},"Silkiss RZ, 1993, THC:YAG nasolacrimal duct recanalization, Ophthalmic Surg, 24, 772",{},{"id":24,"text":749,"url":24,"identifiers":750},"10.1016\u002FS0987-7053(00)00228-8",{"doi":749},{"id":24,"text":752,"url":24,"identifiers":753},"Smith JA, 1986, Endoscopic applications of laser energy, Urol Clin North Am, 13, 405, 10.1016\u002FS0094-0143(21)00225-1",{"doi":754},"10.1016\u002FS0094-0143(21)00225-1",{"id":24,"text":756,"url":24,"identifiers":757},"10.1016\u002Fj.eururo.2005.12.031",{"doi":756},{"id":759,"createTime":760,"updateTime":760,"relativeEntities":761,"slug":762,"properties":763,"entityType":115,"verifyStatus":116,"verifyTime":760,"verifyNote":117,"languages":776,"translateLanguages":24,"viewCount":25,"primaryUrl":777,"fullTextUrl":24,"authors":778,"publicationType":218,"publisherRelationship":961,"citationCount":1012,"citationInfo":1013,"publishDate":1019,"publishYear":1014,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":1020,"openAccess":24,"references":1021,"isForceReanalyzing":363},"d8a6e929-ebd8-452f-a31d-1599228e9280","2025-02-08T05:32:20.158+00:00",[],"Optimising-the-number-of-cores-for-scp-magnetic-resonance-imaging-scp-guided-targeted-and-systematic-transperineal-prostate-biopsy",{"openalex":764,"mag":766,"abstract":768,"title":770,"pm":772,"doi":774},{"VOID":765},"W2971435390",{"VOID":767},"2971435390",{"EN":769},"\u003Cjats:sec>\u003Cjats:title>Objectives\u003C\u002Fjats:title>\u003Cjats:p>To assess cancer detection rates of different target‐dependent transperineal magnetic resonance (\u003Cjats:styled-content style=\"fixed-case\">MR\u003C\u002Fjats:styled-content>)\u002Fultrasonography (\u003Cjats:styled-content style=\"fixed-case\">US\u003C\u002Fjats:styled-content>) fusion‐guided biopsy templates with reduced number of systematic cores.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Patients and Methods\u003C\u002Fjats:title>\u003Cjats:p>Single‐centre outcome of transperineal \u003Cjats:styled-content style=\"fixed-case\">MR\u003C\u002Fjats:styled-content>\u002F\u003Cjats:styled-content style=\"fixed-case\">US\u003C\u002Fjats:styled-content> fusion‐guided biopsies of 487 men with a single target \u003Cjats:styled-content style=\"fixed-case\">MR imaging (MRI)\u003C\u002Fjats:styled-content> lesion, prospectively collected between 2012 and 2016. All men underwent transperineal targeted biopsy (\u003Cjats:styled-content style=\"fixed-case\">TB\u003C\u002Fjats:styled-content>) with two cores, followed by 18–24 systematic sector biopsies (\u003Cjats:styled-content style=\"fixed-case\">SB\u003C\u002Fjats:styled-content>) using the Ginsburg protocol. Gleason score ≥7 prostate cancer detection rates for two‐core \u003Cjats:styled-content style=\"fixed-case\">TB\u003C\u002Fjats:styled-content>, four‐core extended TB (\u003Cjats:styled-content style=\"fixed-case\">eTB\u003C\u002Fjats:styled-content>), 10‐ to 20‐core saturation TB (\u003Cjats:styled-content style=\"fixed-case\">sTB\u003C\u002Fjats:styled-content>) including cores from sectors adjacent to the target, and 14 core ipsilateral TB (\u003Cjats:styled-content style=\"fixed-case\">iTB\u003C\u002Fjats:styled-content>) were compared to combined \u003Cjats:styled-content style=\"fixed-case\">TB\u003C\u002Fjats:styled-content>+SB.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Cancer was detected in 345 men and \u003Cjats:styled-content style=\"fixed-case\">Gleason score\u003C\u002Fjats:styled-content> 7–10 cancer in 211 men. \u003Cjats:styled-content style=\"fixed-case\">TB\u003C\u002Fjats:styled-content> alone detected 67%, \u003Cjats:styled-content style=\"fixed-case\">eTB\u003C\u002Fjats:styled-content> 76%, \u003Cjats:styled-content style=\"fixed-case\">sTB\u003C\u002Fjats:styled-content> 91% and \u003Cjats:styled-content style=\"fixed-case\">iTB\u003C\u002Fjats:styled-content> 91% of these \u003Cjats:styled-content style=\"fixed-case\">Gleason score\u003C\u002Fjats:styled-content> 7–10 cancers. In the subgroup of 33 men (7% of cohort) with an anterior >0.5 mL highly suspicious \u003Cjats:styled-content style=\"fixed-case\">MRI\u003C\u002Fjats:styled-content> lesion and a prostate volume ≤45 mL, four‐core \u003Cjats:styled-content style=\"fixed-case\">eTB\u003C\u002Fjats:styled-content> detected 31 of 32 cancers (97%) and all 26 \u003Cjats:styled-content style=\"fixed-case\">Gleason score\u003C\u002Fjats:styled-content> 7–10 cancers.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusion\u003C\u002Fjats:title>\u003Cjats:p>sTB detected \u003Cjats:styled-content style=\"fixed-case\">Gleason score\u003C\u002Fjats:styled-content> 7–10 cancer in 25% more of the men than a two‐core \u003Cjats:styled-content style=\"fixed-case\">TB\u003C\u002Fjats:styled-content> approach, and in almost as many men (91%) as the 20–26‐core combined TB+SB, while needing only 10–20 cores. A four‐core extended \u003Cjats:styled-content style=\"fixed-case\">TB\u003C\u002Fjats:styled-content> may suffice for large, highly suspicious anterior lesions in small or slightly enlarged prostates.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":771},"Optimising the number of cores for \u003Cscp>magnetic resonance imaging\u003C\u002Fscp>‐guided targeted and systematic transperineal prostate biopsy",{"VOID":773},"31306539",{"VOID":775},"10.1111\u002Fbju.14865",[119],"https:\u002F\u002Fbjui-journals.onlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fbju.14865",[779,814,839,864,889,906,931],{"id":780,"sortIndex":25,"researcher":24,"roles":781,"affiliations":782,"properties":807,"displayName":811,"givenName":24,"familyName":24},"7a9164e9-59c5-4304-a767-da982f46cf58",[],[783,791,799],{"id":784,"sortIndex":25,"affiliation":785,"properties":24},"195210f2-b7a1-4b4b-a702-29b5c8141f66",{"id":784,"createTime":24,"updateTime":24,"relativeEntities":786,"slug":24,"properties":787,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":790,"statistic":24},[],{"title":788},{"EN":789},"CamPARI Prostate Cancer Group, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK",[],{"id":792,"sortIndex":86,"affiliation":793,"properties":24},"ab376e72-1ee4-4848-aabe-a4402ada09c2",{"id":792,"createTime":24,"updateTime":24,"relativeEntities":794,"slug":24,"properties":795,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":798,"statistic":24},[],{"title":796},{"EN":797},"Christof Kastner, Department of Urology, Addenbrooke's Hospital, Cambridge University Hospitals, Hills Road Campus, Cambridge CB2 0QQ, UK and Nienke L. Hansen, CamPARI Prostate Cancer Group, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.",[],{"id":800,"sortIndex":158,"affiliation":801,"properties":24},"e604eaf4-6398-44f7-900a-ba9f0fa95317",{"id":800,"createTime":24,"updateTime":24,"relativeEntities":802,"slug":24,"properties":803,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":806,"statistic":24},[],{"title":804},{"EN":805},"Department of Diagnostic and Interventional Radiology, Faculty of Medicine, University Hospital of Cologne, Medicine and University Hospital of Cologne, Cologne, Germany",[],{"orcid":808,"title":810,"openalex":812},{"VOID":809},"https:\u002F\u002Forcid.org\u002F0000-0002-4917-6539",{"EN":811},"Nienke L. 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K, 2017, Transperineal prostate biopsies for diagnosis of prostate cancer are well tolerated: a prospective study using patient‐reported outcome measures, Asian J Androl, 19, 62, 10.4103\u002F1008-682X.173453",{"doi":1109},"10.4103\u002F1008-682X.173453",{"id":24,"text":1111,"url":24,"identifiers":1112},"10.1016\u002Fj.juro.2017.08.040",{"doi":1111},{"id":24,"text":1114,"url":24,"identifiers":1115},"10.1111\u002Fbju.13859",{"doi":1114},{"id":24,"text":1117,"url":24,"identifiers":1118},"10.1016\u002FS0140-6736(16)32401-1",{"doi":1117},{"id":24,"text":1120,"url":24,"identifiers":1121},"10.1007\u002Fs00330-016-4635-5",{"doi":1120},{"id":24,"text":1123,"url":24,"identifiers":1124},"Greer MD, 2019, Interreader variability of prostate imaging reporting and data system version 2 in detecting and assessing prostate cancer lesions at prostate MRI, AJR Am J Roentgenol, 27, 1",{},{"id":24,"text":1126,"url":24,"identifiers":1127},"10.1111\u002Fbju.12892",{"doi":1126},{"id":1129,"createTime":1130,"updateTime":1130,"relativeEntities":1131,"slug":1132,"properties":1133,"entityType":115,"verifyStatus":116,"verifyTime":1146,"verifyNote":117,"languages":1147,"translateLanguages":24,"viewCount":25,"primaryUrl":1148,"fullTextUrl":24,"authors":1149,"publicationType":218,"publisherRelationship":1275,"citationCount":1326,"citationInfo":1327,"publishDate":1329,"publishYear":1014,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":1330,"openAccess":24,"references":1331,"isForceReanalyzing":363},"55411202-2700-4e7f-b24c-ea28baa933b3","2025-02-08T05:32:20.070+00:00",[],"Use-of-a-trizonal-schema-to-assess-targeting-accuracy-in-prostatic-fusion-biopsy",{"openalex":1134,"mag":1136,"abstract":1138,"title":1140,"pm":1142,"doi":1144},{"VOID":1135},"W3006883997",{"VOID":1137},"3006883997",{"EN":1139},"\u003Cjats:sec>\u003Cjats:title>Objectives\u003C\u002Fjats:title>\u003Cjats:p>To describe the use of a novel 'trizonal' biopsy schema in which 'near‐target' biopsies are taken adjacent to the MRI lesion, in addition to target and systematic biopsies, to determine the accuracy of prostate MRI fusion systems.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Participants and Methods\u003C\u002Fjats:title>\u003Cjats:p>A trizonal biopsy technique was used to evaluate 75 men with small Prostate Imaging Reporting and Data System (PI‐RADS) 3–5 MRI lesions (<15 mm) identified from a prospective cohort of 290 men undergoing multiparametric magnetic resonance imaging (MRI) for suspected prostate cancer at a single high‐volume institution between September 2017 and May 2019. In addition to target and systematic biopsies, near‐target biopsies were taken 4 mm from the apparent border of the MRI lesion. Comparisons were made between highest International Society of Urological Pathology grade and longest tumour length.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Fifty‐three men with significant prostate cancer in the same quadrant as the target were included in the final analysis. The percentages of positive cores from target, near‐target and MRI‐negative zones were 66%, 39% and 17%, respectively. Significant cancer was detected in the near‐target zone in 77% of cases when the target zone was positive. A total of 17% of participants were upgraded by a median (range) of 1 (1–3) grades through the addition of near‐target cores. Notably, 9% of men were diagnosed with clinically significant prostate cancer solely via the near‐target biopsy cores when the target cores were negative.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusion\u003C\u002Fjats:title>\u003Cjats:p>The use of near‐target biopsies as part of a trizonal biopsy schema provides a novel methodology to optimize clinically significant prostate cancer detection.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":1141},"Use of a trizonal schema to assess targeting accuracy in prostatic fusion 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Cancer foci on whole‐mount histology were marked out, coding low‐grade (LG; Gleason 3) and high‐grade (HG; Gleason 4–5) components separately. Measurements of entire tumours were grouped according to intralesional proportion of HG cancer: 0%, <50% and ≥50%; the readings were corrected for specimen shrinkage and correlated with matching lesions on mpMRI. Separate measurements were also taken of HG cancer components only, and correlated against entire lesions on mpMRI. Size discrepancies were used to derive the optimal tumour size and treatment margins for FT.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>There were 122 MRI‐detected cancer lesions in 70 men. The mean linear specimen shrinkage was 8.4%. The overall correlation between histology and MRI dimensions was \u003Cjats:italic>r\u003C\u002Fjats:italic> = 0.79 (\u003Cjats:italic>P\u003C\u002Fjats:italic> < 0.001). Size correlation was superior for tumours with high burden (≥50%) compared to low burden (<50%) of HG cancer (\u003Cjats:italic>r\u003C\u002Fjats:italic> = 0.84 vs \u003Cjats:italic>r\u003C\u002Fjats:italic> = 0.63; \u003Cjats:italic>P\u003C\u002Fjats:italic> = 0.007). Size underestimation by mpMRI was more likely for larger tumours (51% for >12 mm vs 26% for ≤12 mm) and those containing HG cancer (44%, vs 20% for LG only). Size discrepancy analysis suggests an optimal tumour size of ≤12 mm and treatment margins of 5–6 mm for FT. For tumours ≤12 mm in diameter, applying 5‐ and 6‐mm treatment margins would achieve 98.6% and 100% complete tumour ablation, respectively. For tumours of all sizes, using the same margins would ablate >95% of the HG cancer components.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>Multiparametric MRI performance in estimating prostate cancer size, and consequently the treatment margin for FT, is impacted by tumour size and the intralesional heterogeneity of cancer grades.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":1414},"Defining prostate cancer size and treatment margin for focal therapy: does intralesional heterogeneity impact the performance of multiparametric 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\u003Cjats:bold>Objective\u003C\u002Fjats:bold> To assess the outcome of the various methods used in creating continent catheterizable conduits.\u003C\u002Fjats:p>\u003Cjats:p> \u003Cjats:bold>Patients and methods\u003C\u002Fjats:bold> The case notes were reviewed from 89 patients who underwent the formation of 112 continent catheterizable conduits.\u003C\u002Fjats:p>\u003Cjats:p> \u003Cjats:bold>Results\u003C\u002Fjats:bold> Sixty‐five conduits were Mitrofanoff and 47 were antegrade colonic enema (ACE); 21 patients had both. At a mean follow‐up of 34 months, 95 (85%) conduits were still in use. There was no difference in complications between the Mitrofanoff and ACE conduits; 109 (97%) conduits were continent and stomal stenosis occurred 35 (31%). There was no significant difference relating to the conduit used, the reservoir, the stoma type or the stoma site. Only 39% of patients required no revisional surgery.\u003C\u002Fjats:p>\u003Cjats:p> \u003Cjats:bold>Conclusion\u003C\u002Fjats:bold> Although urinary and fecal continence can be achieved in most patients there is a high burden of complications and revisional surgery. All patients should be counselled accordingly.\u003C\u002Fjats:p>",{"EN":1769},"Continent catheterizable conduits: which stoma, which conduit and which reservoir?",{"VOID":1771},"10.1046\u002Fj.1464-410x.2002.02561.x",[119],"https:\u002F\u002Fbjui-journals.onlinelibrary.wiley.com\u002Fdoi\u002F10.1046\u002Fj.1464-410X.2002.02561.x",[1775,1792],{"id":1776,"sortIndex":25,"researcher":24,"roles":1777,"affiliations":1778,"properties":1787,"displayName":1789,"givenName":24,"familyName":24},"0dfb139f-4605-4f4f-b931-c71e1aabf3db",[],[1779],{"id":1780,"sortIndex":25,"affiliation":1781,"properties":24},"e7261dae-fa99-4fa0-b95e-622b3d71418e",{"id":1780,"createTime":24,"updateTime":24,"relativeEntities":1782,"slug":24,"properties":1783,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1786,"statistic":24},[],{"title":1784},{"EN":1785},"Department of Paediatric Surgery, Great Ormond Street Hospital, London, and",[],{"title":1788,"openalex":1790},{"EN":1789},"H.F. 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P, 1980, Cystostomie continente trans‐appendiculaire dans le traitment de vessies neurologique, Chir Ped, 21, 297",{},{"id":24,"text":1886,"url":24,"identifiers":1887},"10.1016\u002FS0022-5347(17)32820-3",{"doi":1886},{"id":24,"text":1889,"url":24,"identifiers":1890},"10.1016\u002FS0090-4295(96)00503-1",{"doi":1889},{"id":24,"text":1892,"url":24,"identifiers":1893},"10.1016\u002FS0022-5347(01)65237-6",{"doi":1892},{"id":24,"text":1895,"url":24,"identifiers":1896},"10.1111\u002Fj.1464-410X.1994.tb00421.x",{"doi":1895},{"id":24,"text":1898,"url":24,"identifiers":1899},"10.1016\u002F0090-4295(91)80075-I",{"doi":1898},{"id":24,"text":1901,"url":24,"identifiers":1902},"Rink RC, 1995, Modification of the Casale vesicostomy: continent diversion without the use of bowel, J Urol, 153, 339A",{},{"id":24,"text":1904,"url":24,"identifiers":1905},"10.1016\u002FS0022-5347(01)67020-4",{"doi":1904},{"id":24,"text":1907,"url":24,"identifiers":1908},"10.1016\u002F0140-6736(90)92834-5",{"doi":1907},{"id":24,"text":1910,"url":24,"identifiers":1911},"10.1016\u002FS0022-5347(01)63717-0",{"doi":1910},{"id":24,"text":1913,"url":24,"identifiers":1914},"10.1016\u002FS0022-3468(98)90381-5",{"doi":1913},{"id":24,"text":1916,"url":24,"identifiers":1917},"10.1016\u002FS0022-5347(01)62515-1",{"doi":1916},{"id":24,"text":1919,"url":24,"identifiers":1920},"10.1046\u002Fj.1464-410X.1997.33724.x",{"doi":1919},{"id":24,"text":1922,"url":24,"identifiers":1923},"10.1016\u002FS0022-5347(05)68230-4",{"doi":1922},{"id":24,"text":1925,"url":24,"identifiers":1926},"Ben‐Chaim J, 1995, Concealed umbilical stoma. description of a modified technique, J Urol, 154, 119, 10.1016\u002FS0022-5347(01)67022-8",{"doi":1927},"10.1016\u002FS0022-5347(01)67022-8",{"id":24,"text":1929,"url":24,"identifiers":1930},"10.1016\u002FS0022-5347(01)66103-2",{"doi":1929},{"id":24,"text":1932,"url":24,"identifiers":1933},"10.1016\u002FS0022-5347(01)61821-4",{"doi":1932},{"id":24,"text":1935,"url":24,"identifiers":1936},"Sumfest JM, 1993, The Mitrofanoff principle in urinary reconstruction, J Urol, 150, 1875, 10.1016\u002FS0022-5347(17)35921-9",{"doi":1937},"10.1016\u002FS0022-5347(17)35921-9",{"id":24,"text":1939,"url":24,"identifiers":1940},"Paterson PJ, 1996, Late conduit perforation in a modified classical Mitrofanoff continent urinary diversion, Br J Urol, 78, 474",{},{"id":1942,"createTime":1943,"updateTime":1943,"relativeEntities":1944,"slug":1945,"properties":1946,"entityType":115,"verifyStatus":116,"verifyTime":1943,"verifyNote":117,"languages":1959,"translateLanguages":24,"viewCount":25,"primaryUrl":1960,"fullTextUrl":24,"authors":1961,"publicationType":218,"publisherRelationship":2026,"citationCount":2076,"citationInfo":2077,"publishDate":2080,"publishYear":2078,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":2081,"openAccess":24,"references":2082,"isForceReanalyzing":363},"82f40813-92fb-4137-a1b9-237f600fc5e2","2025-02-07T23:37:51.254+00:00",[],"Lessons-learned-from-stomal-complications-in-children-with-cutaneous-catheterizable-continent-stomas",{"openalex":1947,"mag":1949,"abstract":1951,"title":1953,"pm":1955,"doi":1957},{"VOID":1948},"W2075501827",{"VOID":1950},"2075501827",{"EN":1952},"\u003Cjats:sec>\u003Cjats:title>OBJECTIVE\u003C\u002Fjats:title>\u003Cjats:p>To evaluate the impact of various factors that might ultimately influence the stoma complication rate associated with the construction of a continent catheterizable urinary (CCU) and Malone antegrade colonic enema (MACE) stoma in children.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>PATIENTS AND METHODS\u003C\u002Fjats:title>\u003Cjats:p>Retrospectively, we reviewed our experience in patients who had a CCU and\u002For MACE stoma reconstructed at our institution from 1992 to 2003. Diagnosis, type of stoma constructed (CCU vs MACE), single vs dual stomas, stomal site, conduit material (appendix, split appendix, Monti‐Yang or ureter), sex, age, patient mobility and body mass index, race and concomitant surgery (e.g. bladder augmentation with or without bladder neck reconstruction) were evaluated for stoma‐related complications. In all, 109 patients (64 males and 45 female), with a mean (\u003Cjats:sc>sd\u003C\u002Fjats:sc>, range) age of 8.6 (5.7, 2–37) years, had 151 stomas constructed during the period of analysis, comprising 56 CCU only, 11 MACE only and 42 (84 stomas) both simultaneously.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>RESULTS\u003C\u002Fjats:title>\u003Cjats:p>The mean (range) follow‐up was 48 (6–144) months. The primary diagnoses were neurogenic bladder in 60 (55%), bladder exstrophy\u002Fepispadias in 17 (16%) and posterior urethral valves in 11 (9%) patients. The umbilicus was the primary site for the CCU stoma in 88 of 98 (90%) cases, while the right lower quadrant was the primary site for MACE in 46 of 53 (87%). After surgery complete stomal continence was provided in 95 of 98 (97%) CCU stoma, whereas the MACE was successful in 52 of 53 (99%). The stoma‐related complications included stenosis in 27, leakage in eight, false passage in four, atrophy in two, keloid in one, and breakdown of the stoma in two. Individually, only greater age and a primary diagnosis of neurogenic bladder were independent risk factors associated with an increased rate of stomal complications and higher incidence of revision (\u003Cjats:italic>P\u003C\u002Fjats:italic> < 0.05).\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>CONCLUSION\u003C\u002Fjats:title>\u003Cjats:p>Stomal complications are extremely common whether CCU or MACE stomas are constructed individually or together. Nevertheless, despite the need for revision, the high stoma continence rate supports their use. Greater age at surgery and a primary diagnosis of neurogenic bladder were associated with a significant increase in the stoma‐related complications and the need for revision.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":1954},"Lessons learned from stomal complications in children with cutaneous catheterizable continent stomas",{"VOID":1956},"15610118",{"VOID":1958},"10.1111\u002Fj.1464-410x.2004.05171.x",[119],"https:\u002F\u002Fbjui-journals.onlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1464-410X.2004.05171.x",[1962,1979,1994,2009],{"id":1963,"sortIndex":25,"researcher":24,"roles":1964,"affiliations":1965,"properties":1974,"displayName":1976,"givenName":24,"familyName":24},"de62fe54-dd83-4b2b-b9eb-bdbbd257b40d",[],[1966],{"id":1967,"sortIndex":25,"affiliation":1968,"properties":24},"3ffdf1ae-8838-4c58-b5b8-123bba4d6cba",{"id":1967,"createTime":24,"updateTime":24,"relativeEntities":1969,"slug":24,"properties":1970,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1973,"statistic":24},[],{"title":1971},{"EN":1972},"Department of Surgery, Division of Urology, University of Colorado School of Medicine, and the Department of Paediatric Urology, The Children's Hospital, Denver, Colorado, USA",[],{"title":1975,"openalex":1977},{"EN":1976},"Albaha Barqawi",{"VOID":1978},"A5027511628",{"id":1980,"sortIndex":86,"researcher":24,"roles":1981,"affiliations":1982,"properties":1989,"displayName":1991,"givenName":24,"familyName":24},"5204808d-b4c1-454e-888d-2aa06f9ab267",[],[1983],{"id":1967,"sortIndex":25,"affiliation":1984,"properties":24},{"id":1967,"createTime":24,"updateTime":24,"relativeEntities":1985,"slug":24,"properties":1986,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":1988,"statistic":24},[],{"title":1987},{"EN":1972},[],{"title":1990,"openalex":1992},{"EN":1991},"M. de Valdenebro",{"VOID":1993},"A5038930178",{"id":1995,"sortIndex":158,"researcher":24,"roles":1996,"affiliations":1997,"properties":2004,"displayName":2006,"givenName":24,"familyName":24},"87e386b2-4116-47a3-822f-a57423bf6231",[],[1998],{"id":1967,"sortIndex":25,"affiliation":1999,"properties":24},{"id":1967,"createTime":24,"updateTime":24,"relativeEntities":2000,"slug":24,"properties":2001,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2003,"statistic":24},[],{"title":2002},{"EN":1972},[],{"title":2005,"openalex":2007},{"EN":2006},"PETER D. FURNESS",{"VOID":2008},"A5068066493",{"id":2010,"sortIndex":180,"researcher":24,"roles":2011,"affiliations":2012,"properties":2019,"displayName":2023,"givenName":24,"familyName":24},"e48e4080-45c2-4194-808e-c4ca624db7c7",[],[2013],{"id":1967,"sortIndex":25,"affiliation":2014,"properties":24},{"id":1967,"createTime":24,"updateTime":24,"relativeEntities":2015,"slug":24,"properties":2016,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2018,"statistic":24},[],{"title":2017},{"EN":1972},[],{"orcid":2020,"title":2022,"openalex":2024},{"VOID":2021},"https:\u002F\u002Forcid.org\u002F0000-0002-4108-447X",{"EN":2023},"Martin A. 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P, 1980, [Trans‐appendicular continent cystostomy in the management of the neurogenic bladder], Chir Pediatr, 21, 297",{},{"id":24,"text":1907,"url":24,"identifiers":2087},{"doi":1907},{"id":24,"text":1871,"url":24,"identifiers":2089},{"doi":1871},{"id":24,"text":1889,"url":24,"identifiers":2091},{"doi":1889},{"id":24,"text":1880,"url":24,"identifiers":2093},{"doi":1880},{"id":24,"text":2095,"url":24,"identifiers":2096},"10.1016\u002FS0022-5347(05)64515-6",{"doi":2095},{"id":24,"text":2098,"url":24,"identifiers":2099},"10.1016\u002FS0022-5347(05)66213-1",{"doi":2098},{"id":24,"text":2101,"url":24,"identifiers":2102},"10.1007\u002FBF00182565",{"doi":2101},{"id":24,"text":1922,"url":24,"identifiers":2104},{"doi":1922},{"id":24,"text":1913,"url":24,"identifiers":2106},{"doi":1913},{"id":24,"text":2108,"url":24,"identifiers":2109},"10.1046\u002Fj.1464-410x.2001.02208.x",{"doi":2108},{"id":24,"text":1874,"url":24,"identifiers":2111},{"doi":1874},{"id":24,"text":2113,"url":24,"identifiers":2114},"10.1038\u002Fsj.sc.3100991",{"doi":2113},{"id":24,"text":1919,"url":24,"identifiers":2116},{"doi":1919},{"id":24,"text":2118,"url":24,"identifiers":2119},"10.1016\u002FS0022-5347(01)67155-6",{"doi":2118},{"id":24,"text":2121,"url":24,"identifiers":2122},"10.1016\u002FS0022-5347(05)64436-9",{"doi":2121},{"id":24,"text":2124,"url":24,"identifiers":2125},"10.1016\u002FS0022-5347(05)66215-5",{"doi":2124},{"id":24,"text":2127,"url":24,"identifiers":2128},"10.1016\u002FS0022-5347(05)65911-3",{"doi":2127},{"id":24,"text":2130,"url":24,"identifiers":2131},"Israelsson LA, 1997, Overweight and healing of midline incisions: the importance of suture technique, European J Surg, 163, 175",{},{"id":24,"text":2133,"url":24,"identifiers":2134},"10.1159\u002F000020323",{"doi":2133},{"id":2136,"createTime":2137,"updateTime":2137,"relativeEntities":2138,"slug":2139,"properties":2140,"entityType":115,"verifyStatus":116,"verifyTime":2137,"verifyNote":117,"languages":2153,"translateLanguages":24,"viewCount":25,"primaryUrl":2154,"fullTextUrl":24,"authors":2155,"publicationType":218,"publisherRelationship":2237,"citationCount":2288,"citationInfo":2289,"publishDate":2291,"publishYear":1862,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":2292,"openAccess":24,"references":2293,"isForceReanalyzing":363},"358948d2-0fdc-46d5-8bf7-263f414eabc8","2025-02-07T23:37:51.226+00:00",[],"A-high-easy-to-treat-complication-rate-is-the-price-for-a-continent-stoma",{"openalex":2141,"mag":2143,"abstract":2145,"title":2147,"pm":2149,"doi":2151},{"VOID":2142},"W1574082330",{"VOID":2144},"1574082330",{"EN":2146},"\u003Cjats:p> \u003Cjats:bold>Objective\u003C\u002Fjats:bold> To evaluate the conduit‐related complications and their treatment in Mitrofanoff continent urinary diversion and antegrade colonic enema (ACE) procedures.\u003C\u002Fjats:p>\u003Cjats:p> \u003Cjats:bold>Patients and methods\u003C\u002Fjats:bold> The files of 53 patients (18 men and 35 women) in whom 58 continent stomas were created were retrospectively reviewed. Gender, age, age at the time of surgery, underlying disease, concomitant surgery, abdominal position of the stoma, follow‐up, complications and treatment were assessed. The mean (\u003Cjats:sc>sd\u003C\u002Fjats:sc>) age at the time of surgery was 19 (13) years; 30 patients were aged <15 years and the mean follow‐up was 2.8 (1.9) years. Fifty‐three continent vesicostomy‐type Mitrofanoff stomas were constructed and five ACE procedures performed. Forty‐five stomas were in the umbilicus and 13 on the abdominal wall. For 45 conduits the appendix was used; in the other 13 a transverse tubularized ileal segment according to Monti was created.\u003C\u002Fjats:p>\u003Cjats:p> \u003Cjats:bold>Results\u003C\u002Fjats:bold> There were stoma‐related complications in 19 patients (36%), with 27 in all and stomal stenosis accounting for more than half. Five patients had urinary leakage. The median time to the first complication was 9 months. Multiple regression analysis showed that gender and stoma location were the only significant determinants of the complication\u002Ffollow‐up ratio. Women had more complications than men and umbilical stomas fared worse than those on the abdominal wall. Age, underlying disease and type of stoma were not significantly related to the complication\u002Ffollow‐up ratio. The complication was treated by one procedure in 13 patients; four needed two and two needed three surgical revisions. Most complications were relatively easy to treat, i.e. dilatation in five, endoscopic incision in one, re‐anastomosis in four, Y‐V plasty in seven, a new channel in two, reimplantation in three, a bladder cuff in two for stomal leakage, and abdominoplasty in two. Only one stoma had to be abandoned.\u003C\u002Fjats:p>\u003Cjats:p> \u003Cjats:bold>Conclusion\u003C\u002Fjats:bold> The complication rate for continent small‐diameter stoma is high. However, most complications are relatively easy to treat. Despite these complications, patient satisfaction remains high.\u003C\u002Fjats:p>",{"EN":2148},"A high easy‐to‐treat complication rate is the price for a continent stoma",{"VOID":2150},"12133058",{"VOID":2152},"10.1046\u002Fj.1464-410x.2002.02805.x",[119],"https:\u002F\u002Fbjui-journals.onlinelibrary.wiley.com\u002Fdoi\u002F10.1046\u002Fj.1464-410X.2002.02805.x",[2156,2173,2188,2205,2220],{"id":2157,"sortIndex":25,"researcher":24,"roles":2158,"affiliations":2159,"properties":2168,"displayName":2170,"givenName":24,"familyName":24},"d538cc80-3a6d-40ca-b80c-0ad93a52a99c",[],[2160],{"id":2161,"sortIndex":25,"affiliation":2162,"properties":24},"ce2bb303-6630-45e8-aa6e-8b81cca6d368",{"id":2161,"createTime":24,"updateTime":24,"relativeEntities":2163,"slug":24,"properties":2164,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2167,"statistic":24},[],{"title":2165},{"EN":2166},"Departments of Urology and Paediatric Urology, Ghent University Hospital, Gent, Belgium",[],{"title":2169,"openalex":2171},{"EN":2170},"J. De Ganck",{"VOID":2172},"A5011868302",{"id":2174,"sortIndex":86,"researcher":24,"roles":2175,"affiliations":2176,"properties":2183,"displayName":2185,"givenName":24,"familyName":24},"e8b41d60-fac4-4540-a5d0-1e96176c7190",[],[2177],{"id":2161,"sortIndex":25,"affiliation":2178,"properties":24},{"id":2161,"createTime":24,"updateTime":24,"relativeEntities":2179,"slug":24,"properties":2180,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2182,"statistic":24},[],{"title":2181},{"EN":2166},[],{"title":2184,"openalex":2186},{"EN":2185},"Karel Everaert",{"VOID":2187},"A5113589573",{"id":2189,"sortIndex":158,"researcher":24,"roles":2190,"affiliations":2191,"properties":2198,"displayName":2202,"givenName":24,"familyName":24},"a2251a49-a21a-4262-bdf6-7758f812abe1",[],[2192],{"id":2161,"sortIndex":25,"affiliation":2193,"properties":24},{"id":2161,"createTime":24,"updateTime":24,"relativeEntities":2194,"slug":24,"properties":2195,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2197,"statistic":24},[],{"title":2196},{"EN":2166},[],{"orcid":2199,"title":2201,"openalex":2203},{"VOID":2200},"https:\u002F\u002Forcid.org\u002F0009-0002-2091-2691",{"EN":2202},"Erik Van Laecke",{"VOID":2204},"A5052490210",{"id":2206,"sortIndex":180,"researcher":24,"roles":2207,"affiliations":2208,"properties":2215,"displayName":2217,"givenName":24,"familyName":24},"a198505e-3ac9-46e2-a322-6178aaef2f88",[],[2209],{"id":2161,"sortIndex":25,"affiliation":2210,"properties":24},{"id":2161,"createTime":24,"updateTime":24,"relativeEntities":2211,"slug":24,"properties":2212,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2214,"statistic":24},[],{"title":2213},{"EN":2166},[],{"title":2216,"openalex":2218},{"EN":2217},"W. 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P, 1980, Cystostomie continent trans‐appendiculaire dans le traitement des vessies neurologiques, Chir Pediatr, 21, 297",{},{"id":24,"text":1907,"url":24,"identifiers":2298},{"doi":1907},{"id":24,"text":1889,"url":24,"identifiers":2300},{"doi":1889},{"id":24,"text":2302,"url":24,"identifiers":2303},"10.1016\u002FS0022-5347(05)68228-6",{"doi":2302},{"id":24,"text":1874,"url":24,"identifiers":2305},{"doi":1874},{"id":24,"text":2108,"url":24,"identifiers":2307},{"doi":2108},{"id":24,"text":1919,"url":24,"identifiers":2309},{"doi":1919},{"id":24,"text":2311,"url":24,"identifiers":2312},"10.1016\u002FS0022-5347(05)67599-4",{"doi":2311},{"id":24,"text":2314,"url":24,"identifiers":2315},"10.1016\u002FS0022-3468(99)90656-5",{"doi":2314},{"id":24,"text":2317,"url":24,"identifiers":2318},"10.1016\u002Fs0090-4295(99)00046-1",{"doi":2317},{"id":24,"text":1922,"url":24,"identifiers":2320},{"doi":1922},{"id":24,"text":2322,"url":24,"identifiers":2323},"10.1016\u002FS0094-0143(05)70421-3",{"doi":2322},{"id":24,"text":2325,"url":24,"identifiers":2326},"Fishwick JE, 2000, The Mitrofanoff procedure: does it last?, Br J Urol, 85, 496, 10.1046\u002Fj.1464-410x.2000.00514.x",{"doi":2327},"10.1046\u002Fj.1464-410x.2000.00514.x",{"id":24,"text":1871,"url":24,"identifiers":2329},{"doi":1871},{"id":2331,"createTime":2332,"updateTime":2332,"relativeEntities":2333,"slug":2334,"properties":2335,"entityType":115,"verifyStatus":116,"verifyTime":2332,"verifyNote":117,"languages":2348,"translateLanguages":24,"viewCount":25,"primaryUrl":2349,"fullTextUrl":24,"authors":2350,"publicationType":218,"publisherRelationship":2419,"citationCount":2469,"citationInfo":2470,"publishDate":2473,"publishYear":2471,"citationAnalyzeStatus":23,"lastCitationAnalyze":24,"indexDatabases":2474,"openAccess":24,"references":2475,"isForceReanalyzing":363},"82d8e357-7416-4adf-8e4d-0ff6ba778047","2025-02-02T15:28:05.119+00:00",[],"Digital-three-dimensional-modelling-of-the-male-pelvis-and-bicycle-seats-impact-of-rider-position-and-seat-design-on-potential-penile-hypoxia-and-erectile-dysfunction",{"openalex":2336,"mag":2338,"abstract":2340,"title":2342,"pm":2344,"doi":2346},{"VOID":2337},"W2015273709",{"VOID":2339},"2015273709",{"EN":2341},"\u003Cjats:sec>\u003Cjats:title>OBJECTIVE\u003C\u002Fjats:title>\u003Cjats:p>To digitally model (three‐dimensional, 3D) the course of the pudendal arteries relative to the bony pelvis in the adult male, and to identify sites of compression with different bicycle riding positions as a potential cause of penile hypoxia and erectile dysfunction.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>SUBJECTS AND METHODS\u003C\u002Fjats:title>\u003Cjats:p>3D models were made from computed tomography scans of one adult male pelvis (a healthy volunteer) and three bicycle seats. Models were correlated with lateral radiographs of a seated rider to determine potential vascular compression between the bony pelvis and seats at different angles of rider positioning.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>RESULTS\u003C\u002Fjats:title>\u003Cjats:p>Pelvis\u002Fseat models suggest that the most likely site of compression of the internal pudendal artery is immediately below the pubic symphysis, especially with the rider leaning forward. For an upright rider, the internal pudendal arteries do not appear to be compressed between the seat and the bony pelvis. Leaning partly forward with arms extended, the seat\u002Fsymphysis areas were reduced to 73 mm\u003Cjats:sup>2\u003C\u002Fjats:sup> with standard seat and 259 mm\u003Cjats:sup>2\u003C\u002Fjats:sup> with a grooved seat. Leaning fully forward, the seat\u002Fsymphysis areas decreased (no space with standard seat; 51 mm\u003Cjats:sup>2\u003C\u002Fjats:sup> with a grooved seat) and both the ischial tuberosities and the pubic symphysis might be in contact with the seat.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>CONCLUSION\u003C\u002Fjats:title>\u003Cjats:p>A grooved seat allows better preservation of the seat\u002Fsymphysis space than a standard seat, but the rider’s position is more important for preserving the seat‐symphysis space (and reducing compression) than is seat design alone. Any factors which influence the seat‐symphysis space (including an individual’s anatomy, seat design and rider position) can increase the potential for penile hypoxia and erectile dysfunction\u002Fperineal numbness.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":2343},"Digital three‐dimensional modelling of the male pelvis and bicycle seats: impact of rider position and seat design on potential penile hypoxia and erectile dysfunction",{"VOID":2345},"17227499",{"VOID":2347},"10.1111\u002Fj.1464-410x.2007.06542.x",[119],"https:\u002F\u002Fbjui-journals.onlinelibrary.wiley.com\u002Fdoi\u002F10.1111\u002Fj.1464-410X.2007.06542.x",[2351,2370,2385,2402],{"id":2352,"sortIndex":25,"researcher":24,"roles":2353,"affiliations":2354,"properties":2363,"displayName":2367,"givenName":24,"familyName":24},"7e499a30-3bc8-4938-b082-4f4dc00bd723",[],[2355],{"id":2356,"sortIndex":25,"affiliation":2357,"properties":24},"80887aae-0803-4ed4-bf88-3096d26082e5",{"id":2356,"createTime":24,"updateTime":24,"relativeEntities":2358,"slug":24,"properties":2359,"entityType":24,"verifyStatus":24,"verifyTime":24,"verifyNote":24,"languages":24,"translateLanguages":24,"viewCount":24,"url":24,"parentIds":2362,"statistic":24},[],{"title":2360},{"EN":2361},"Departments of Radiology and Urology, Dartmouth‐Hitchcock Medical Center, Lebanon NH and",[],{"orcid":2364,"title":2366,"openalex":2368},{"VOID":2365},"https:\u002F\u002Forcid.org\u002F0000-0001-7125-7717",{"EN":2367},"John M. 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