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The α-l-rhamnopyranosyl-(1→2)-α-l-arabinopyranoside group of α-hederin alters the cytotoxicity of its aglycon, hederagenin. This study explored the role of this saccharide unit in the cytotoxic effect of α-hederin and the possibility of its use as a carrier moiety in prodrugs of anticancer agents. A new convenient and practical procedure for the preparation of 4-methoxybenzoyl-2,3,4-tri-O-benzoyl-α-l-rhamnopyranosyl-(1→2)-3,4-O-dibenzoyl-β-l-arabinopyranoside (2) from 4-methoxybenzoyl-β-l-arabinopyranoside was accomplished using four steps with an overall yield of 63%. The use of BF3-OEt2 as a catalyst in the glycosylation step in this procedure had a large advantage over the TMSOTf catalyst used in the usual method. Moreover, the key intermediate obtained in this procedure, 4-methoxybenzoyl-2,3,4-tri-O-benzoyl-α-l-rhamnopyranosyl-(1→2)-α-l-arabinopyranoside (7), was selectively transformed to 4-methoxybenzoyl-2,3,4-tri-O-benzoyl-α-l-rhamnopyranosyl-(1→2)-4-O-acetyl-α-l-arabinopyranoside (9) and 4-methoxybenzoyl-2,3,4-tri-O-benzoyl-α-l-rhamnopyranosyl-(1→2)-3-O-benzoyl-β-l-arabinopyranoside (10). These derivatives did not show any cytotoxicity against human cancer cell lines. Thus the 3-O-α-l-rhamnopyranosyl-(1→2)-α-l-arabinopyranoside could be used as a nontoxic carrier moiety to enhance the activity of anticancer drugs.",{"EN":122,"VI":123},"A convenient preparation of a disaccharide motif and its role in the cytotoxicity of the triterpenoid saponin, α-hederin","Điều chế thuận tiện một motif disaccharide và vai trò của nó đối với độc tính tế bào của saponin triterpenoid α-hederin",{"VOID":125},"Arao, T., Udayama, M., Kino, J., Nohara, T., Funakoshi, T., and Kojima, S., Preventive effects of saponins from puerariae radix (the root of Pueraria lobata Ohwi) on in vitro immunological injury of rat primary hepatocyte cultures. Biol. Pharm. Bull., 20(9), 988–991 (1997).\nBang, S. C., Kim, Y., Lee, J. H., and Ahn, B. Z., Triterpenoid saponins from the roots of Pulsatilla Koreana. J. Nat. Prod., 68, 268–272 (2005a).\nBang, S. C., Lee, J. H., Song, G. Y., Kim, D. H., Yoon, M. Y., and Ahn, B. Z., Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship. Chem. Pharm. Bull., 53, 1451–1454 (2005b).\nBhandari, P., Gray, A. I., and Rastogi, R. P., Triterpenoid saponins from caltha palustris. Planta Med., 53, 98–100 (1987).\nBouchra, M., Calinaud, P., and Gelas, J., A new method of orthoesterification, under kinetic control, at non-anomeric positions. Application to the D-glucose and D-mannose series and selective hydrolysis of the corresponding orthoesters. Carbohydr. Res., 267, 227–237 (1995).\nBrown, R. S. and Wahl, R. I., Overexpression of Glut-1 glucose transporter in human breast cancer. An immunohistochemical study. Cancer, 72, 2979–2983 (1993).\nChoi, J. S. and Woo, W. S., Triterpenoid glycosides from the roots of Patrinia scabiosaefolia. Planta Med. 53, 62–64 (1987).\nFinch, P., Iskander, G. M., and Siriwardena, A. H., Convenient syntheses of 2,3,5-tri-O-benzyl-arabino-and-ribofuranoses via their allyl glycosides. Carbohydr. Res., 210, 319–325 (1991).\nHalmos, T., Santarromana, M., Antonakis, K., and Scherman, D., Synthesis of glucose-chlorambucil derivatives and their recognition by the human GLUT1 glucose transporter. Eur. J. Pharmacol., 318, 477–484 (1996).\nHanessian, S. and Roy, R., Chemistry of spectinomycin: its total synthesis, stereocontrolled rearrangement, and analogs. Can. J. Chem., 63, 163–172 (1985).\nHostettmann, K. and Marston, A., Saponins. Cambridge University Press, Cambridge (1995).\nIszard, M. B., Liu, J., and Klaassen, C. D., Effect of several metallothionin inducers on oxidative stress defense mechanisms in rats. Toxicology, 104, 25–33 (1995).\nJeong, H. G. and Park, H. Y., The prevention of carbon tetra-chloride-induced hepatotoxicity in mice by a α-hederin: Inhibition of cytochrome P450 2E1 expression. Biochem. Mol. Int., 45, 163–170 (1998).\nKamiya, S., Esaki, S., and Tanaka, R., Studies on α-l-rhamnosidase. Part I. Synthesis of 2-O-α-l-rhamnopyranosyl-l-arabinopyranose. Agric. Biol. Chem., 48, 1353–1355 (1984).\nKaren, P., Martin, C., and Laurence, V. N., Synthesis of α-hederine, d-hederine, and related triterpenoid saponins. Eur. J. Org. Chem., 1588–1603 (2004).\nKim, Y. K., Kim, R. G., Park, S. J., Ha, J. H., Choi, J. W., Park, H. J., and Lee, K. T., In vitro antiinflammatory activity of kalopanaxsaponin A isolated from Kalopanax pictus in murine macrophage RAW 264.7 cells. Biol. Phram. Bull. 25(4), 472–476 (2002).\nKizu, H., Shimana, H., and Tomimori, T., Studies on the constituents of Clematis species. VI. The constituents of Clematis stans Sieb. et Zucc. Chem. Pharm. Bull., 43, 2187–2194 (1995)\nLi, D. W., Hyun, J. E., Jeong, C. S., Kim, Y. S., and Lee, E. B., Antiinflammatory activity of α-hederin methyl ester from the alkaline hydrolysate of the butanol fraction of Kalopanax pictus bark extract. Biol. Pharm. Bull., 26(4), 429–433 (2003).\nLiptak, A., Szurmai, Z., Nanasi, P., and Neszmelyi, A., Carbon-13 NMR study of methyl and benzyl ethers of l-arabinose and oligosaccharides having l-arabinose at the reducing end. Synthesis of 2-O-β-D-glucopyranosyl-, 2-O-α-l-rhamnopyranosyl-, 3-O-β-D-glucopyranosyl-2-O-α-l-rhamnopyranosyl-, and 4-O-β-D-glucopyranosyl-2-O-α-l-rhamnopyranosyl-l-arabinose. Tetrahedron, 38(23), 3489–3497 (1982).\nMba, G. C., Larget, M., Guiraud-Dauriac, H., De Meo, M., Elias, R., and Dumenil, G., The protective activity of α-hederin against H2O2 genotoxicity in HepG2 cells by alkaline cornet assay. Mutat. Res., 445, 9–20 (1999).\nMonks, A., Scudiero, D., Skehan, P., Shoemaker, R., Paull, K., Vistica, D., Hose, C., Langley, J., Cronise, P., Vaigro, W. A., Gray, G. M., Campbell, H., Mayo, J., and Boyd, M., Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J. Natl. Cancer Inst., 83, 757–766 (1991).\nNakamura, T., Komori, C., Lee, Y., Hashimoto, F., Yahara, S., Nohara, T., and Ejima, A., Cytotoxic activities of solanum steroidal glycosides. Biol. Pharm. Bull., 19, 564–566 (1996).\nPark, H. J., Kwon, S. H., Lee, J. H., Lee, K. H., Miyamoto, K., and Lee, K. T., Kalopanaxsaponin A is a basic saponin structure for the anti-tumor activity of hederagenin monodesmosides. Planta Med., 67, 118–121 (2001).\nPolt, R., Porreca, F., Szabo, L. Z., Bilsky, E. J., Davis, P., Abbruscato, T. J., Davis, T. P., Horvath, R., Yamamura, H. I., and Hruby, V. J., Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier. Proc. Natl. Acad. Sci. U.S.A., 91, 7114–7118 (1994).\nQuetin-Leclercq, J., Elias, R., Balansard, G., Bassleer, R., and Angenot, L., Cytotoxic activity of some triterpenoid saponins. Planta Med., 58, 279–281 (1992).\nSchmidt, R. R. and Michel, J., Facile synthesis of α-and β-O-glycosyl imidates; Preparation of glycosides and disaccharides. J. Angew. Chem. Int. Ed., 19, 731–732 (1980).\nShaojiang, D., Biao, Y., Jianming, X, and Yongzheng, H., Highly efficient glycosylation of sapogenins. J. Org. Chem., 64, 7265–7266 (1999).\nShayne, C. G., Drug discovery Handbook. John Wiley & Sons, New York, pp. 739–740 (2005).\nShi, J. Z. and Liu, G. T., Effect of α-hederin and sapindoside B on hepatic microsomal cytochrome P-450 in mice. Chung Kuo Li Hsueh Pao, 17, 264–266 (1996).\nSkehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J. T., Bokesh, H., Kenney, S., and Boyd, M. R., New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer Inst., 82, 1107–1112 (1990).\nUriel, C., Egron, M. J., Santarromana, M., Scherman, D., Antonakis, K., and Herscovici, J., Hexose keto-C-glycoside conjugates: design, synthesis, cytotoxicity, and evaluation of their affinity for the glucose transporter Glut-1. Bioorg. Med. Chem., 4, 2081–2090 (1996).\nZiegler, T., Bien, F., and Jurisch, C., Chemoenzymic synthesis of enantiomerically pure alkene 1,2-diols and glycosides thereof. Tetrahedron: Asymmetry, 9, 765–780 (1998).",{"VOID":127},"10.1007\u002Fs12272-001-1192-7","PUBLICATION",[130],"VI","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs12272-001-1192-7",[133,149,162,175,188,201],{"id":134,"sortIndex":21,"researcher":20,"roles":135,"affiliations":137,"properties":146,"displayName":148,"givenName":20,"familyName":20},"dba092ba-b7a2-4cb3-bacf-7500ec31256a",[136],"AUTHOR",[138],{"id":139,"sortIndex":21,"affiliation":140,"properties":20},"15e01cf8-889a-4919-8c64-8daacda6fa83",{"id":139,"createTime":20,"updateTime":20,"relativeEntities":141,"slug":20,"properties":142,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":145,"statistic":20},[],{"title":143},{"VI":144},"College of Pharmacy, Chungnam National University, Daejeon, Korea",[],{"title":147},{"VI":148},"Seong-Cheol 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an antiviral agent with a bitter taste, has been clinically used up to a maximum of 4 g daily in 4–8 doses. In this investigation, isoprinosine was microencapsulated with ethylcellulose 22 cps, 50 cps and 100 cps by means of polymer deposition from cyclohexane through temperature change. Complete removal of cyclohexane from the microcapsules was necessary, since ethylcellulose-coated microcapsules obtained from cyclohexane medium were heavily solvated with cyclohexane and formed lumps even after drying. The displacement of cyclohexane byn-hexane during isolation of microcapsules (Method III) or the freezing of the final-washed microcapsules before drying (Method II) provided the dried products which were more discrete microcapsules than those which were simply dried in the air overnight (Method I). Method III was especially the most effective procedure in preparing finer and more discrete microcapsules. The drug-release from microcapsules was influenced by the ratio of core to wall, the viscosity grade of ethylcellulose and the overall microcapsule size. The release rate was adequately fitted to both the first-order and the diffusion-controlled processes. It is therefore possible to design the release-controlled microcapsules with ethylcellulose of different viscosity along with various core to wall ratio.",{"EN":285,"VI":286},"Microencapsulation of isoprinosine with ethylcellulose","Vi nang hóa isoprinosine sử dụng tá dược ethylcellulose",{"VOID":288},"Nielsen, P. and Beckett, A. H.: The metabolism and excretion in man of N,N-dimethylamino-isopropanol and p-acetamidobenzoic acid after adminstration of isoprinosine.J. Pharm. Pharmacol.,33, 549–550 (1981).\nReynolds, J. E. F. (eds):Martindale The Extra Pharmacopoeia 29th Ed., The Pharmaceutical Press, London, p. 696 (1989).\nLao, L. M., Alora, B. D., Guevarra, R., Mendoza, T. L. and Alora, A. T.: Isoprinosine in the treatment of infectious hepatitis among Filipino patients.J. Manila Medical Society,10, 151–156 (1972).\nAhumada, M. P., Amezquita, D. and Biro, C. E.: Clinical investigation with prinosine (isoprinosine) in patients with herpes simplex and herpes zoster,El Medico (Mexico),5, 75–82 (1972).\nSolano, E.: Viral dermatosis treated with prinosine (isoprinosine),Revista Medica de Costa Rica,445, 469–474 (1973).\nSolano, J. L. L. and Baeza, J. C. S.: Methisoprinol in some common infectious viral diseases,El Medico (Mexico),23(1), 1–10 (1973).\nKim, C. K., Kim, S. N., Cha, H. S., Kim, Y. B. and Yu, B. S.: Microencapsulation of pharmaceuticals (I): ethylcellulose coated microcapsules containing pipethanate hydrochloride.J. Kor. Pharm. Sci.,10(2): 8–16 (1980).\nKim, C. K., Hwang, S. W., Hwang, S. J. and Lah, W. L.: Development of sustained release microcapsules containing ion exchange resindextromethorphan hydrobromide complex.J. Kor. Pharm. Sci.,19(2), 99–107 (1989).\nMorse, L. D., Boroshok, M. J. and Grabner, R. W.: Process of isolating cyclohexane-free ethylcellulose microcapsules,U.S. Pat., 4,107,072 (1978).\nMorse, L.D. and Hammes, P.A.: Method of microencapsulation,U.S. Pat., 4,123,382 (1978).\nGupta, P. K., Hung, C. T. and Perrier, D. G.: Albumin microspheres. I. Release characteristics of adriamycin.Int. J. Pharm.,33, 137–146 (1986).\nGupta, P. K., Hung, C. T. and Perrier, D. G.: Albumin microspheres. II. Effect of stabilization temperature on the release of adriamycin.Int. J. Pharm.,33, 147–153 (1986).",{"VOID":290},"10.1007\u002FBF02876874","VERIFIED","2025-01-23T23:03:47.276+00:00","Auto Verify",[130],"https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002FBF02876874",[297,312],{"id":298,"sortIndex":21,"researcher":20,"roles":299,"affiliations":300,"properties":309,"displayName":311,"givenName":20,"familyName":20},"53a03c52-54b1-4960-aeb1-d4546682d216",[136],[301],{"id":302,"sortIndex":21,"affiliation":303,"properties":20},"1924a669-75f4-498a-b4d0-a5a3d598681c",{"id":302,"createTime":20,"updateTime":20,"relativeEntities":304,"slug":20,"properties":305,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":308,"statistic":20},[],{"title":306},{"VI":307},"College of Pharmacy, Seoul National University, Seoul, Korea",[],{"title":310},{"VI":311},"Chong-Kook Kim",{"id":313,"sortIndex":100,"researcher":20,"roles":314,"affiliations":315,"properties":324,"displayName":326,"givenName":20,"familyName":20},"8a40f0b1-ec5d-407c-b39c-9e99410344a4",[136],[316],{"id":317,"sortIndex":21,"affiliation":318,"properties":20},"678060d3-3596-4f9c-8324-b144b4494a12",{"id":317,"createTime":20,"updateTime":20,"relativeEntities":319,"slug":20,"properties":320,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":323,"statistic":20},[],{"title":321},{"VI":322},"Chungnam National University, Taejeon, Korea",[],{"title":325},{"VI":326},"Sung-Joo Hwang",{"url":295,"publisher":328,"properties":378},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":329,"slug":10,"properties":330,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":334,"manageAffiliations":347,"indexDatabases":358,"url":94,"thumbnailPath":20,"statistic":373,"gsStatistic":20,"type":107,"analyzePriority":20},[],{"issn":331,"title":332,"eissn":333},{"VOID":13},{"EN":15},{"VOID":17},[335,339,343],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":336,"label":337,"description":338,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},{"id":30,"createTime":20,"updateTime":20,"relativeEntities":340,"label":341,"description":342,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":33},{},{"id":36,"createTime":20,"updateTime":20,"relativeEntities":344,"label":345,"description":346,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":39},{},[348,353],{"id":43,"createTime":20,"updateTime":20,"relativeEntities":349,"slug":20,"properties":350,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":352,"statistic":20},[],{"title":351},{"EN":47},[],{"id":50,"createTime":20,"updateTime":20,"relativeEntities":354,"slug":20,"properties":355,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":357,"statistic":20},[],{"title":356},{"EN":54},[],[359,366],{"id":58,"indexDatabase":360,"url":69,"indexYears":70,"academicFieldIds":365,"indexDatabaseRanking":75},{"id":60,"createTime":20,"updateTime":20,"relativeEntities":361,"label":362,"description":363,"key":66,"publicationTags":364,"standard":20},[],{"EN":63,"VI":63},{"EN":63,"VI":65},[68],[72,73,74],{"id":77,"indexDatabase":367,"url":90,"indexYears":20,"academicFieldIds":372,"indexDatabaseRanking":20},{"id":79,"createTime":20,"updateTime":20,"relativeEntities":368,"label":369,"description":370,"key":86,"publicationTags":371,"standard":20},[],{"EN":82,"VI":82},{"EN":84,"VI":85},[88,89],[92,93],{"impactFactor":21,"impactFactorByYear":374,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":97,"totalPublicationByYear":375,"totalCitation":21,"totalCitationByYear":376,"totalCitationPerPublication":21,"totalCitationPerPublicationByYear":377,"hindexLast5Year":21,"hindex":21},{},{"1985":99,"1986":100,"1987":100,"1991":100,"1994":99,"1995":100,"1996":99,"1998":100,"1999":100,"2002":101,"2003":99,"2004":99,"2005":99,"2006":99,"2007":102,"2008":102,"2009":100,"2010":103,"2011":104,"2012":100,"2013":100,"2014":100,"2015":99,"2016":99,"2020":100,"2022":99,"2023":100},{},{},{"pages":379,"volume":381},{"VOID":380},"298-304",{"VOID":382},"14","1991-12-01",1991,[75,88],{"id":387,"createTime":388,"updateTime":389,"relativeEntities":390,"slug":391,"properties":392,"entityType":128,"verifyStatus":291,"verifyTime":402,"verifyNote":293,"languages":20,"translateLanguages":403,"viewCount":21,"primaryUrl":404,"fullTextUrl":20,"authors":405,"publicationType":214,"publisherRelationship":477,"citationCount":20,"citationInfo":20,"publishDate":533,"publishYear":534,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":535,"openAccess":20,"references":20,"isForceReanalyzing":274},"aba918d9-f8a3-4a07-9f7f-6051994b47b2","2024-01-15T06:09:11.631+00:00","2026-09-07T11:17:35.631+00:00",[],"Cytotoxic-ergosterols-frompaecilomyces-sp-J300",{"abstract":393,"title":395,"references":398,"doi":400},{"EN":394},"Seven ergosterol derivatives (1~7) were isolated from silkworm larvae infected withPaecilomyces sp. J300. On the basis of spectroscopic means, their structures have been elucidated as3β,5α-dihydroxy-ergosta-7,22-diene (1),5α,6α-epoxy-(22E,24R)-ergosta-8(14), 22-diene-3β,7α-diol (2),5α,6α-epoxy-(22E,24R)-ergosta-8,22-diene-3β,7β-diol (3),ergosta-4,6,8(14),22-tetraene-3-one (4),ergosterol (5),ergosterol endoperoxide (6),3β,5α-dihydroxy-6β-methoxyer-gosta-7,22-diene (7). Compounds3~7 showed moderate cytotoxicity against five tumor cells.",{"EN":396,"VI":397},"Cytotoxic ergosterols frompaecilomyces sp. J300","Các ergosterol gây độc tế bào từ Paecilomyces sp. J300",{"VOID":399},"Bernardini, M., Carilli, A., Pacioni, G. and Santurbano, B., Isolation of beauvericin fro.Paecilomyces fumoso-roseus.Phytochemistry, 14, 1865 (1975).\nDomenech, J., Prieto, A., Barasoain, I., Gomez-Miranda, B., Bernabe, M., Leal, J. A., Galactomannans from the cell walls of species ofPaecilomyces sect.Paecilomyces and their teleomorphs as immunotaxonomic markers.Microbiology (heading, England), 145, 2789–2796 (1999).\nGoad, L. J. and Akihisa, T., Analysis of Sterols, Blackie Academic & Professional, an imprint of Chapman & Hall, London, p. 375 (1997).\nGoldstein, A. S., Synthesis and bioevaluation of Δ7-5-desa-turase inhibitors, an enzyme late in the biosynthesis of the fungal sterol ergosterol.J. Med. Chem., 39, 5092–5099 (1996).\nGreca, M. D., Fiorentino, A., Molinaro, A. Monaco, P. and Previtera, L. Steroidal 5,6-epoxides fromArum italicum.Nat. Prod. Lett., 2, 27–32 (1993).\nHorn, W. S., Smith, J. L., Bills, G. F., Raghoobar, S. L., Helms, G. L., Kurtz, M. B., Marrinan, J. A., Frommer, B. R., Thornton, R. A., Mandala, S. M., Sphingofungins E and F: novel serinepalmitoyl transferase inhibitors fro.Paecilomyces variotii.J. Antibiotics, 45, 1692–1696 (1992).\nJinming, G., Lin, Hu and Jikai, L. A novel sterol from Chinese trufflesTuberindicum.Steroids, 66, 771–775 (2001).\nKawagishi, H., Katsumi, R., Sazawa, T., Mizuno, T., Hagiwara, T. and Nakamura, T. Cytotoxic steroids from the mushroomAgaricusblazei.Phytochemistry, 27, 2777–2779 (1988).\nKinjo, N., Kaizu, Y., Taketomo, N. and Tsunoo, A. Physiological activities of the extracts from cultured mycelial ofCordyceps militaris (Vuill.).Fr. Bull. Gen. Educ. Tokyo Med. Dent. Univ. 26, 7–14 (1996).\nKwon, H. C., Moon, H. I., Choi, S. H., Lee, J. O., Cho, S. Y., Jung, I. Y., Kim, S. Y. and Lee, K. R. Cytotoxic Constituents ofBombycis corpus.Yakhak Hoeji, 43, 169–172 (1999).\nLee, K. R., Peroxide Constituents in the Natural Product Research,Kor. J. Pharmacogn., 22 (3), 145–155 (1991).\nLi, S. P., Li, P., Dong, T. T. and Tsim, K. W., Anti-oxidation activity of different types of natura.Cordyceps sinensis and culturedCordyceps mycelia.Phytomedicine, 8, 207–212 (2001).\nNam, K. S., Jo, Y. S., Kim, Y. H., Hyun, J. W. and Kim, H. W., Cytotoxic activities of acetoxyscirpenediol and ergosterol peroxide fro.Paecilomyces tenuipes.Life Sciences, 69, 229–237 (2001).\nPemberton, R. W., Insects and other arthropods used as drugs in Korean traditional medicine.J. Ethnopharmacol., 65, 207–216 (1999).\nRossi, C., Tuttobello, L., Ricci, M. Casinovi, C.G. and Radios, L., Leucinostatin D, a novel peptide antibiotic fromPaecilomyces marquandii.J. Antibiotics, 40, 130–133 (1987).\nSchulte, K. E., Rcker, G. and Fachmann, H. Ergosta-4,6,8 (14),22-tetraenon-(3) als inhaltsstoff des Larchenschwammes.Tetrahedron Lett., 46, 4763–4764 (1968).\nShanghai Science and Technologic Publisher and JungDam Publisher, The Dictionary of Chinese Drugs, JungDam Publisher, Seoul, pp. 1427–1430 (1997).\nShim, J. Y., Lee, Y. S., Lim, S. S., Shin, K. H., Hyun, J. E., Kim, S. Y. and Lee, E. B., Pharmacological activities o.Paecilomyces japonica, A new typeCordyceps sp.,Kor. J. Pharmacogn., 31, 163–167 (2000).\nSkehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J. T., Bokesch, H., Kenney, S. and Boyd, M. R. New colorimetric cytotoxicity assay for anticancer-drug screening.J. Natl. Cancer Inst., 82, 1107–1112 (1990).\nYamashita, Y., Saitoh, Y., Ando, K., Takahashi, K., Ohno, H. and Nakano, H., Saintopin, a new antitumor antibiotic with topo-isomerase dependent DNA cleavage activity, fromPaecilomyces.J. Antibiotics, 43, 1344–1346 (1990).\nYue, J. M., Chen, S. N., Lin, Z. W. and Sun, H. D. Sterol from the fungusLactarium volemus.Phytochemistry, 56, 801–806 (2001).",{"VOID":401},"10.1007\u002FBF02977003","2025-01-21T16:39:16.825+00:00",[130],"https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002FBF02977003",[406,421,436,449,464],{"id":407,"sortIndex":21,"researcher":20,"roles":408,"affiliations":409,"properties":418,"displayName":420,"givenName":20,"familyName":20},"19252c57-4131-498f-8857-481f0634ff43",[136],[410],{"id":411,"sortIndex":21,"affiliation":412,"properties":20},"4c446b88-b24f-4ce5-a261-daebdb982879",{"id":411,"createTime":20,"updateTime":20,"relativeEntities":413,"slug":20,"properties":414,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":417,"statistic":20},[],{"title":415},{"VI":416},"Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University, Suwon, Korea",[],{"title":419},{"VI":420},"Hak Cheol Kwon",{"id":422,"sortIndex":100,"researcher":20,"roles":423,"affiliations":424,"properties":433,"displayName":435,"givenName":20,"familyName":20},"b1591ef1-75dc-433b-8255-3a6b29128018",[136],[425],{"id":426,"sortIndex":21,"affiliation":427,"properties":20},"1e06fc1d-21f8-4f9a-87c8-99bccda2f2a8",{"id":426,"createTime":20,"updateTime":20,"relativeEntities":428,"slug":20,"properties":429,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":432,"statistic":20},[],{"title":430},{"VI":431},"Department of Sericulture & Entomology, National Institute Agricultural Science and Technology, Suwon, Korea",[],{"title":434},{"VI":435},"Sang Deuk Zee",{"id":437,"sortIndex":99,"researcher":20,"roles":438,"affiliations":439,"properties":446,"displayName":448,"givenName":20,"familyName":20},"8885e182-6da0-48fe-b4ec-ca48629365b0",[136],[440],{"id":426,"sortIndex":21,"affiliation":441,"properties":20},{"id":426,"createTime":20,"updateTime":20,"relativeEntities":442,"slug":20,"properties":443,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":445,"statistic":20},[],{"title":444},{"VI":431},[],{"title":447},{"VI":448},"Sae Yun Cho",{"id":450,"sortIndex":102,"researcher":20,"roles":451,"affiliations":452,"properties":461,"displayName":463,"givenName":20,"familyName":20},"6009f4f0-36b2-42ed-82ff-82c2441c8a77",[136],[453],{"id":454,"sortIndex":21,"affiliation":455,"properties":20},"f8e2a824-a1b3-4649-b58c-fe0fddd00740",{"id":454,"createTime":20,"updateTime":20,"relativeEntities":456,"slug":20,"properties":457,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":460,"statistic":20},[],{"title":458},{"VI":459},"Kora Research Institute of Chemical Technology, Daejeon, Korea",[],{"title":462},{"VI":463},"Sang Un Choi",{"id":465,"sortIndex":101,"researcher":20,"roles":466,"affiliations":467,"properties":474,"displayName":476,"givenName":20,"familyName":20},"d3d98548-e1a4-4f4a-8dd2-ed029530e5a8",[136],[468],{"id":411,"sortIndex":21,"affiliation":469,"properties":20},{"id":411,"createTime":20,"updateTime":20,"relativeEntities":470,"slug":20,"properties":471,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":473,"statistic":20},[],{"title":472},{"VI":416},[],{"title":475},{"VI":476},"Kang Ro Lee",{"url":404,"publisher":478,"properties":528},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":479,"slug":10,"properties":480,"entityType":18,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":21,"subjectFields":484,"manageAffiliations":497,"indexDatabases":508,"url":94,"thumbnailPath":20,"statistic":523,"gsStatistic":20,"type":107,"analyzePriority":20},[],{"issn":481,"title":482,"eissn":483},{"VOID":13},{"EN":15},{"VOID":17},[485,489,493],{"id":24,"createTime":20,"updateTime":20,"relativeEntities":486,"label":487,"description":488,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":27},{},{"id":30,"createTime":20,"updateTime":20,"relativeEntities":490,"label":491,"description":492,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":33},{},{"id":36,"createTime":20,"updateTime":20,"relativeEntities":494,"label":495,"description":496,"parentId":20,"standard":20,"scholarHubFieldId":20},[],{"EN":39},{},[498,503],{"id":43,"createTime":20,"updateTime":20,"relativeEntities":499,"slug":20,"properties":500,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":502,"statistic":20},[],{"title":501},{"EN":47},[],{"id":50,"createTime":20,"updateTime":20,"relativeEntities":504,"slug":20,"properties":505,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":507,"statistic":20},[],{"title":506},{"EN":54},[],[509,516],{"id":58,"indexDatabase":510,"url":69,"indexYears":70,"academicFieldIds":515,"indexDatabaseRanking":75},{"id":60,"createTime":20,"updateTime":20,"relativeEntities":511,"label":512,"description":513,"key":66,"publicationTags":514,"standard":20},[],{"EN":63,"VI":63},{"EN":63,"VI":65},[68],[72,73,74],{"id":77,"indexDatabase":517,"url":90,"indexYears":20,"academicFieldIds":522,"indexDatabaseRanking":20},{"id":79,"createTime":20,"updateTime":20,"relativeEntities":518,"label":519,"description":520,"key":86,"publicationTags":521,"standard":20},[],{"EN":82,"VI":82},{"EN":84,"VI":85},[88,89],[92,93],{"impactFactor":21,"impactFactorByYear":524,"i10Index":21,"i10IndexLast5Year":21,"totalPublication":97,"totalPublicationByYear":525,"totalCitation":21,"totalCitationByYear":526,"totalCitationPerPublication":21,"totalCitationPerPublicationByYear":527,"hindexLast5Year":21,"hindex":21},{},{"1985":99,"1986":100,"1987":100,"1991":100,"1994":99,"1995":100,"1996":99,"1998":100,"1999":100,"2002":101,"2003":99,"2004":99,"2005":99,"2006":99,"2007":102,"2008":102,"2009":100,"2010":103,"2011":104,"2012":100,"2013":100,"2014":100,"2015":99,"2016":99,"2020":100,"2022":99,"2023":100},{},{},{"pages":529,"volume":531},{"VOID":530},"851-855",{"VOID":532},"25","2002-12-01",2002,[75,88],{"id":537,"createTime":538,"updateTime":539,"relativeEntities":540,"slug":541,"properties":542,"entityType":128,"verifyStatus":19,"verifyTime":20,"verifyNote":20,"languages":552,"translateLanguages":554,"viewCount":21,"primaryUrl":555,"fullTextUrl":20,"authors":556,"publicationType":214,"publisherRelationship":602,"citationCount":20,"citationInfo":20,"publishDate":653,"publishYear":654,"citationAnalyzeStatus":19,"lastCitationAnalyze":20,"indexDatabases":655,"openAccess":20,"references":656,"isForceReanalyzing":274},"200dfeda-4f04-449f-ba47-011ac5034d4b","2024-04-11T04:22:56.577+00:00","2026-09-07T06:14:13.032+00:00",[],"Synthesis-of-new-2-thiouracil-5-sulphonamide-derivatives-with-antibacterial-and-antifungal-activity",{"abstract":543,"title":545,"keywords":548,"doi":550},{"EN":544},"2-Thiouracil-5-sulphonic acidN-(4-acetylphenyl) Amide (1) was reacted with a series of aromatic aldehydes giving chalcones2 (Claisen-Schemidt reaction), some of these chalcones were reacted with urea and thiourea giving pyrimidine-2-one and pyrimidine-2 thione derivatives respectively of the type3a,b and4a,b. In addition many chalcones were reacted with hydroxylamine hydrochloride giving isoxazoline derivatives5a,b. They could also reacted with Phenylhydrazine to give pyrazoline derivatives6a,b, chalcones also were reacted withethylcyano acetate and\u002For malononitryl in pyridine giving pyran derivatives7a,c and8a,c In another pathway chalcones were epoxidised by H2O2 giving epoxides9a,c which in turn were reacted with Phenylhydrazine giving 4-hydroxypyrazoline derivatives10a,c. In another reaction chalcones were reacted with ethylcyanoacetate in presence of amm.acetate giving pyridone derivatives11a,d which could be prepared also in exellent yield from compound 1 by its reaction with certain aromatic aldehydes and ethylcyanoacetate in presence of ammonium acetate. Finally, compound 1 was reacted with semicarbazide giving semicarbazone intermediate12 which in turn was reacted with thionyl chloride giving thiadiazole derivative13. The biological effects of some of the new synthesized compounds were also investigated.",{"EN":546,"VI":547},"Synthesis of new 2-thiouracil-5-sulphonamide derivatives with antibacterial and antifungal activity","Tổng hợp các dẫn xuất 2-thiouracil-5-sulphonamide mới có hoạt tính kháng khuẩn và kháng nấm",{"EN":549},"",{"VOID":551},"10.1007\u002FBF02978199",[553],"EN",[130],"https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002FBF02978199",[557,574,589],{"id":558,"sortIndex":21,"researcher":20,"roles":559,"affiliations":560,"properties":569,"displayName":573,"givenName":20,"familyName":20},"fc7612cb-a3fe-45f1-a915-70ee3d892791",[],[561],{"id":562,"sortIndex":21,"affiliation":563,"properties":20},"f4ac978e-e2fe-42b3-9782-d06057a4cd52",{"id":562,"createTime":20,"updateTime":20,"relativeEntities":564,"slug":20,"properties":565,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":568,"statistic":20},[],{"title":566},{"EN":567},"Department of Medicinal Chemistry, National Research Centre, Dokki, Cairo, Egypt",[],{"email":570,"title":572},{"VOID":571},"omarfathalla@yahoo.com",{"EN":573},"O. 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Apigenin prolonged sleep time induced by pentobarbital similar to muscimol, a GABAA receptors agonist. Apigenin also increased sleep rate and sleep time in the combined administration with pentobarbital at the sub-hypnotic dosage, and showed synergic effects with muscimol in potentiating sleep onset and enhancing sleep time induced by pentobarbital. In addition, both of apigeinin and pentobarbital increased chloride influx in primary cultured cerebellar granule cells. Apigenin increased glutamate decarboxylase (GAD) and had no effect on the expression of GABAA receptorα-, β-, γ-subunits in n hippocampus of mouse brain, showing different expression of subunits from pentobarbital treatment group. In conclusion, it is suggested that apigenin augments pentobarbital-induced sleep behaviors through chloride ion channel activation.",{"EN":1290},"Enhancement of pentobarbital-induced sleep by apigenin through chloride ion channel activation",{"VOID":1292},"[\"4195288095994759505\"]",{"VOID":1294},"Avallone, R., Zanoli, P., Puia, G., Kleinschnitz, M., Schreier, P., and Baraldi, M., Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochem. Pharmacol., 59, 1387–1394 (2000).\nBrailowsky, S. and Garcia, O., Ethanol, GABA and epilepsy. Arch. Med. Res., 30, 3–9 (1999).\nBuddhala, C., Hsu, C. C., and Wu, J. Y., A novel mechanism for GABA synthesis and packaging into synaptic vesicles. Neurochem. Int., 55, 9–12 (2009).\nChebib, M. and Johnston, G. A., GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology. J. Med. Chem., 43, 1427–1447 (2000).\nChistina Grobin, A., Inglefield, J. R., Schwartz-Bloom, R. D., Devaud, L. L., and Morrow, A. L., Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties. Brain Res., 827, 1–11 (1999).\nDarias, V., Abdala, S., Martin-Herrera, D., Tello, M. L., and Vega, S., CNS effects of a series of 1,2,4-triazolyl heterocarboxylic derivatives. Pharmazie, 53, 477–481 (1998).\nDavies, M., Bateson, A. N., and Dunn, S. M., Molecular biology of the GABA(A) receptor: functional domains implicated by mutational analysis. Front. Biosci., 1, d214–d233 (1996).\nDe Sousa, F. C., Pereira, B. A., Lima, V. T., Lacerda, C. D., Melo, C. T., Barbosa-Filho, J. M., Vasconcelos, S. M., and Viana, G. S., Central nervous system activity of yangambin from Ocotea duckei Vattimo (Lauraceae) in mice. Phytother. Res., 19, 282–286 (2005).\nDoghramji, K., The epidemiology and diagnosis of insomnia. Am. J. Manag. Care, 12, S214–S220 (2006).\nFollesa, P., Porcu, P., Sogliano, C., Cinus, M., Biggio, F., Mancuso, L., Mostallino, M. C., Paoletti, A. M., Purdy, R. H., Biggio, G., and Concas, A., Changes in GABAA receptor gamma 2 subunit gene expression induced by long-term administration of oral contraceptives in rats. Neuropharmacology, 42, 325–336 (2002).\nGanzera, M., Pocher, A., and Stuppner, H., Differentiation of Cirsium japonicum and C. setosum by TLC and HPLCMS. Phytochem. Anal., 16, 205–209 (2005).\nGlowinski, J. and Iversen, L. L., Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J. Neurochem., 13, 655–669 (1966).\nHan, H., Ma, Y., Eun, J. S., Hong, J. T., and Oh, K. W., Anxiolytic-like effects of cyclopeptide fraction alkaloids of Zizyphi Spinosi Semen: possible involvement of GABAA receptors. Biomol. Ther., 16, 261–269 (2008).\nJager, A. K., Krydsfeldt, K., and Rasmussen, H. B., Bioassayguided isolation of apigenin with GABA-benzodiazepine activity from Tanacetum parthenium. Phytother. Res., 23, 1642–1644 (2009).\nKumar, S., Alam, M. N., Rai, S., Bashir, T., Mcginty, D., and Szymusiak, R., Central nervous system sites of the sleep promoting effects of eszopiclone in rats. Neuroscience, 181, 67–78 (2011).\nMa, Y., Han, H., Eun, J. S., Kim, H. C., Hong, J. T., and Oh, K. W., Sanjoinine A isolated from Zizyphi Spinosi Semen augments pentobarbital-induced sleeping behaviors through the modification of GABA-ergic systems. Biol. Pharm. Bull., 30, 1748–1753 (2007).\nMa, Y., Ma, H., Jo, Y. J., Kim, D. S., Woo, S. S., Li, R., Hong, J. T., Moon, D. C., Oh, K. W., and Eun, J. S., Honokiol potentiates pentobarbital-induced sleeping behaviors through GABAA receptor Cl- channel activation. Biomol. Ther., 16, 328–335 (2008).\nMa, Y., Ma, H., Eun, J. S., Nam, S. Y., Kim, Y. B., Hong, J. T., Lee, M. K., and Oh, K. W., Methanol extract of Longanae Arillus augments pentobarbital-induced sleep behaviors through the modification of GABAergic systems. J. Ethnopharmacol., 122, 245–250 (2009).\nMacdonald, R. L. and Olsen, R. W., GABAA receptor channels. Annu. Rev. Neurosci., 17, 569–602 (1994).\nMarder, M. and Paladini, A. C., GABA(A)-receptor ligands of flavonoid structure. Curr. Top. Med. Chem., 2, 853–867 (2002).\nMartinez, A. L., Dominguez, F., Orozco, S., Chavez, M., Salgado, H., Gonzalez, M., and Gonzalez-Trujano, M. E., Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice. J. Ethnopharmacol., 106, 250–255 (2006).\nMöhler, H., Fritschy, J. M., and Rudolph, U., A new benzodiazepine pharmacology. J. Pharmacol. Exp. Ther., 300, 2–8 (2002).\nNazaruk, J. and Jakoniuk, P., Flavonoid composition and antimicrobial activity of Cirsium rivulare (Jacq.) All. flowers. J. Ethnopharmacol., 102, 208–212 (2005).\nOhayon, M. M., Methodology of a study on insomnia in the general population. Encephale, 28, 217–226 (2002).\nPark, J. C., Lee, J. H., and Choi, J. S., A flavone diglycoside from Cirsium japonicum var. ussuriense. Phytochemistry, 39, 261–262 (1995).\nRudolph, U., Crestani, F., and Möhler, H., GABA(A) receptor subtypes: dissecting their pharmacological functions. Trends Pharmacol. Sci., 22, 188–194 (2001).\nRudolph, U. and Möhler, H., GABA-based therapeutic approaches: GABAA receptor subtype functions. Curr. Opin. Pharmacol., 6, 18–23 (2006).\nSegal, D. S. and Kuczenski, R., Tyrosine hydroxylase activity: regional and subcellular distribution in the brain. Brain Res., 68, 261–266 (1974).\nShukla, S. and Gupta, S., Apigenin: a promising molecule for cancer prevention. Pharm. Res., 27, 962–978 (2010).\nTillakaratne, N. J. K., Medina-Kauwe, L., and Gibson, K. M., Gamma-aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues. Comp. Biochem. Physiol. A Physiol., 112, 247–263 (1995).\nTobler, I., Kopp, C., Deboer, T., and Rudolph, U., Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtype. Proc. Natl. Acad. Sci. U. S. A., 98, 6464–6469 (2001).\nViola, H., Wasowski, C., Levi De Stein, M., Wolfman, C., Silveira, R., Dajas, F., Medina, J. H., and Paladini, A. C., Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med., 61, 213–216 (1995).\nWest, M. R. and Molloy, C. R., A microplate assay measuring chloride ion channel activity. Anal. Biochem., 241, 51–58 (1996).\nWolfman, C., Viola, H., Marder, M., Wasowski, C., Ardenghi, P., Izquierdo, I., Paladini, A. C., and Medina, J. H., Anxioselective properties of 6,3′-dinitroflavone, a high-affinity benzodiazepine receptor ligand. Eur. J. Pharmacol., 318, 23–30 (1996).\nYang, C. S., Landau, J. M., Huang, M. T., and Newmark, H. L., Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu. Rev. Nutr., 21, 381–406 (2001).\nZhu, S. and Baker, R. 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establish a standard of quality control and to identify reliable Achyranthis Radix, three phytoecdysones including ecdysterone (1), 25R-inokosterone (2) and 25S-inokosterone (3) were determined by quantitative HPLC\u002FUV analysis. Three phytoecdysones were separated with an YMC J’sphere ODS C18 column (250 mm × 4.6 mm, 4 μm) by isocratic elution using 0.1% formic acid in water and acetonitrile (85:15, v\u002Fv%) as the mobile phase. The flow rate was 1.0 mL\u002Fmin and the UV detector wavelength was set at 245 nm. The standards were quantified by HPLC\u002FUV from Achyranthes bidentata Blume and Achyranthes japonica Nakai, as well as Cyathula capitata Moq. and Cyathula officinalis Kuan, which are of a different genus but are comparative herbs. The method was successfully used in the analysis of Achyranthis Radix of different geographical origin or genera with relatively simple conditions and procedures, and the assay results were satisfactory for linearity, recovery, precision, accuracy, stability and robustness. The HPLC analytical method for pattern recognition analysis was validated by repeated analysis of eighteen A. bidentata Blume samples and ten A. japonica Nakai samples. The results indicate that the established HPLC\u002FUV method is suitable for quantitation and pattern recognition analyses for quality evaluation of Achyranthis Radix.",{"EN":1529},"High performance liquid chromatography used for quality control of Achyranthis Radix",{"VOID":1531},"[\"15814493910794612628\"]",{"VOID":1533},"Bai, Y., Yu, Z. X., Sun, S. Q., Zhu, F. Y., Wang, D., and Chen, Z. H., Determinatio of ecdysterone in Radix Achranthis Bidentatae by near infrared diffuse reflectance spectroscopy. Chin. Tradit. Herb Drugs, 36, 1391–1394 (2005).\nHe, Q., Ge, Z. W., Song, Y., and Cheng, Y. Y., Quality evaluation of Cortex Moutan by high performance liquid chromatography coupled with diode array detector and electrospray ionization tandem mass spectrometry. Chem. Pharm. Bull., 54, 1271–1275 (2006).\nKim, J. H., Kim, J. M., and Kang, D. H., A study on discriminative criteria of 6 kinds of Achyranthis Radix using HPLC\u002FDAD. Kor. J. Herbology, 23, 109–116 (2008).\nKorea Food and Drug Administration, Korean Pharmacopoeia IX, Part II (K. P.). Shinil Books, Seoul, p. 1159, (2008).\nLi, J., Li, H. P., Li, P., and Qi, H., Simultaneous qualitation and quantification of four phytoecdysones in Radix Achranthis Bidentatae by high-performance liquid chromatography with diode array detection. Biomed. Chormatogr., 21, 823–828 (2007a).\nLi, J., Li, P., Li, H. J., Song, Y., Bi, Z. M., and Li, Y. J., Simultaneous qualification and quantification of eight triterpenoids in radix Achyranthis bidentatae by high-performance liquid chromatography with evaporative light scattering detection and mass spectrometric detection. J. Sep. Sci., 30, 843–850 (2007b).\nLi, Y. J., Wei, H. L., Qi, L. W., Chen, J., Ren, M. T., and Li, P., Characterization and identification of saponins in Achyranthes bidentata by rapid-resolution liquid chromatography with electrospray ionization quadrupole time-offlight tandem mass spectrometry. Rapid Commun. Mass Spectrom., 24, 2975–2985 (2010).\nLiang, Y. Z., Xie, P. S., and Chan, K. J., Quality control of herbal medicines. Chromatogr. B, 812, 53–70 (2004).\nMa, Y., Che, Z. T., Bi, K. S., Wang X., and Huang, W., Determination of ecdysterone in the root of Achyranthes bidentata Bl. by Rp-HPLC. Yao Xue Xue Bao, 35, 313–315 (2000).\nPark, J. S., Seong, N. S., and Lee, Y. J., Comparative study on the anti-oxidative effects of Achyranthis japonicae Radix, Achyranthis Bidentatae Radix and Cyathulae Radix. Kor. J. Herbology, 22, 155–167 (2007).\nSon, K. H., Hwang, J. H., Lee, S. H., Park, J. H., Kang, J. K., Chang, S. Y., and Lee, K. S., Isolation and quantitative determination of 20-hydroxyecdysone from Achyranthis radix. Kor. J. Pharmacogn., 30, 335–339 (1999).\nSong, L. R., Hong, X., and Ding, X. L., Modern Chinese Materia Medica Lexicon. People Health Publishing House Press, Beijing, p. 399, (2001).\nTanaka, K., Kuba, Y., Ina, A., Watanabe, H., and Komatsu, K., Prediction of cyclooxygenase inhibitory activity of curcuma rhizome from chromatograms by multivariate analysis. Chem. Pharm. Bull., 56, 963–940 (2008).\nThe Minister of Health, Labor and welfare of Japan, The Japanese Pharmacopoeia 15th Edition (J. P.). The Minister of Health, Labor and Welfare of Japan Press, Tokyo, p. 1211, (2008).\nThe Pharmacopoeia Commission of the PRC (C. P.). Pharmacopoeia of People’s Republic of China. Chemical Industry Press, Beijing, p. 67, (2010).\nWang, L., Xu, X. Y., Zheng, Y. M., Fu, S. Q., and Yi, Z. H., Detaermination of total phytoecdysone from Achyranthes bidentata by spectrometry. Lishizhen Med. Mater. Med. Res., 16, 18–19 (2005).\nWang, Y. Y., Zhan, Z. J., Wang, X. W., Xu, X. Y., and Zhang, H. J., Study on the fingerprints of Achyranthes bidentata Bl. by HPLC\u002FUV\u002FMS. Chin. Med. Mater., 26, 787–789 (2003).\nZhang, H., Zhang, Z. Z., and Wei, Y. J., An approach to content of ecdysterone in Achyranthes bidentata BL. collected in different period. J. Chin. Med. Mater., 23, 734–735 (2000).\nZhang, Y., Wei, Y., and Su, H., Determination of ecdysterone in Achyranthes bidentata Blume by RP-HPLC with ultrasonic extraction. Chin. J. Spectroscopy Lab., 19, 668–671 (2002).\nZhu, T. T., Liang, H., Zhao, Y. Y., and Wang, B., Isotation and structure identification of C-25 epimers of inokosterone from Achyranthes bidentata Blume. Yao Xue Xue Bao, 39, 913–916 (2004).",{"VOID":1535},"10.1007\u002Fs12272-012-0815-2","2024-05-13T11:11:10.364+00:00","https:\u002F\u002Flink.springer.com\u002Farticle\u002F10.1007\u002Fs12272-012-0815-2",[1539,1554,1567,1580,1595,1610],{"id":1540,"sortIndex":21,"researcher":20,"roles":1541,"affiliations":1542,"properties":1551,"displayName":1553,"givenName":20,"familyName":20},"5c335377-e991-4f13-a2c7-c916acfb5c64",[136],[1543],{"id":1544,"sortIndex":21,"affiliation":1545,"properties":20},"0e0e3405-8b9b-407a-8206-07c688673cae",{"id":1544,"createTime":20,"updateTime":20,"relativeEntities":1546,"slug":20,"properties":1547,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1550,"statistic":20},[],{"title":1548},{"VI":1549},"College of Pharmacy, Catholic University of Daegu, Gyeongsan, Korea",[],{"title":1552},{"VI":1553},"Bing Tian 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Son",{"id":1596,"sortIndex":101,"researcher":20,"roles":1597,"affiliations":1598,"properties":1607,"displayName":1609,"givenName":20,"familyName":20},"e174f778-67b5-4a1a-80c8-974f0ebddf8d",[136],[1599],{"id":1600,"sortIndex":21,"affiliation":1601,"properties":20},"a5ec554b-a747-4344-9408-5d82855eeabe",{"id":1600,"createTime":20,"updateTime":20,"relativeEntities":1602,"slug":20,"properties":1603,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1606,"statistic":20},[],{"title":1604},{"VI":1605},"College of Pharmacy, Yeungnam University, Gyeongsan, Korea",[],{"title":1608},{"VI":1609},"Jong Keun Son",{"id":1611,"sortIndex":104,"researcher":20,"roles":1612,"affiliations":1613,"properties":1620,"displayName":1622,"givenName":20,"familyName":20},"fedb5c0f-de60-4d44-aea1-9ddbad628f13",[136],[1614],{"id":1544,"sortIndex":21,"affiliation":1615,"properties":20},{"id":1544,"createTime":20,"updateTime":20,"relativeEntities":1616,"slug":20,"properties":1617,"entityType":20,"verifyStatus":20,"verifyTime":20,"verifyNote":20,"languages":20,"translateLanguages":20,"viewCount":20,"url":20,"parentIds":1619,"statistic":20},[],{"title":1618},{"VI":1549},[],{"title":1621},{"VI":1622},"Mi Hee 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(5a,b) and substituted hydroxythiazoles8a,b were synthesized from the reaction of4a,b with hydrazine hydrate and mercaptoacetic acid respectively. Compounds5a,b and8a,b were also obtained from coupling of2a,b with6 and7, respectively. 4H-1,4-Benzothiazine11 was prepared from1 and10. The reaction of the diazonium salts2a-c with diethyl 3-amino-2-cyanopent-2-en-1,5-dicarboxylate12 was also reported.",{"EN":1694},"Activated nitriles in heterocyclic synthesis: Syntheses of thiazole, pyrazole and 4H-1,4-benzothiazine derivatives",{"VOID":1696},"[\"8942771540450282513\"]",{"VOID":1698},"Godman, L.S. and Gilman, A.G.:The Pharmacological Bases of Therapeutics. Mcmillan Co., London 1177 (1970).\nBayer, A.:Medicinal Chemistry, 2nd ed, 1960, Interscience Publishers, Inc., New York.\nBentley and Driver’s:Textbook of Pharmaceutical Chemistry, 8th ed, London Oxford University, Press, New York, Toronto, 688 (1969).\nTŕefouël, J., Tŕefouël, Mme. J., Nitti, F. and Bovet.: Action of p-aminophenylsulfamide in experimental streptococcus infections of mice and rabbits.Compt. Rend. Soc. Biol. 120, 756 (1935).\nLong, H.P. and Bliss, A.E.: p-Aminobenzenesulfonamide and its derivatives. Experimental and clinical observations on their use in the treatment of β-hemolytic streptococci infection.J. Am. Med. Assoc. 108, 32 (1937).\nNorthey, E.H.:The Sulphonamides and Allied Compounds. Reinhold, New York (1948).\nBurger, A.:Medicinal Chemistry, 3rd ed, part 1, Wiley-Interscience, New York, London, Sydney, Toronto, 255 (1970).\nElnagdi, M.H., Hafez, E.A., El-Fahham, H.A. and Kandeel, E.M.: Reactions with heterocyclic amides (VIII): Synthesis of some new imidazo [1,2-b] pyrazole derivatives.J. Heterocyclic Chem. 17, 73 (1980).\nElnagdi, M.H., Elmoghayar, M.R.H., Hafez, E.A.A. and Alnima, H.H.: Reaction of 2-arylhydrazono-3-oxonitriles with hydroxylamines: Synthesis of 3-amino-4-arylazoisoxazoles.J. Org. Chem. 40(18), 2604 (1975).\nElgemeie, G.E.H., Elfahham, H.A., Hassan, E.S.M. and Elnagdi, M.H.: Activated nitriles in heterocyclic synthesis: The reaction of nitriles with mercapto acids.Z. Naturforsch 38b, 781 (1983).\nElnagdi, M.H., Elfahham, H.A., Ghozlan, S.A.S. and Elgemeie, G.E.H.: Activated nitriles in heterocyclic synthesis: A new procedure for the synthesis of pyrimidine derivatives.J. Chem. Soc. Perkin Trans.I, 2667 (1982).\nShen, T.Y., Clark, R.L., Pessolano, A.A., Witzel, B.E. and Lanza, T.J. (Merck and Co., Inc.) U.S. 4,038,396 (Cl. 424–256; A61K31\u002F44), 26 Jul. (1977),Appl. 574,173,02 May (1975).\nHayakawa, I., Tanaka, Y. and Nagata, Y.: Thiazolopyridine carboxylic acid derivatives (Daiichi Seiyaku Co., Ltd.)Japan. Kokai 7783,588 (Cl. C07D513\u002F04), 12 Jul. (1977),Appl. 76\u002F199, 01 Jan. (1976).\nBehr, L.C., Fusco, R. and Jarbe, C.H.: The Chemistry of Pyrazoles, Pyrazolines, Pyrazolidines, Indazoles and Condensed Rings In Chemistry of Heterocyclic Compounds. Weissberger, Ed. A., Interscience Publishers, New York (1967).\nElnagdi, M.H., Khalifa, M.A.E., Ibraheim, M.K.A. and Elmoghayar, M.R.H.: The reaction of nitriles with mercaptoacetic acid. A new synthesis of thiazole derivatives.J. Heterocyclic Chem.,18, 877 (1981).\nGupta, R.R. and Gautam, R. K.: Synthesis of 5-substituted 4H-1,4-benzothiazines.Die Pharmazie,3,40,203 (1985).\nEl-Agamey, A.A., El-Taweel, F.M.A. and Amer, F.A.: Synthesis of some new pyrazolo [1,5-a] pyrimidine and pyrazolo [1,5-c]-as-triazine derivatives.Collection Czechoslovak Chem. 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