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Constant change by acquired mutations and metabolic reprogramming contribute to the high inter- and intratumor heterogeneity of malignant cells, their selective growth advantage, and their resistance to anticancer therapies. In the modern era of integrative biomedicine, realizing that a personalized approach could benefit therapy treatments and patients’ prognosis, we should focus on cancer-driving advantageous modifications. Namely, reactive oxygen species (ROS), known to act as regulators of cellular metabolism and growth, exhibit both negative and positive activities, as do antioxidants with potential anticancer effects. Such complexity of oxidative homeostasis is sometimes overseen in the case of studies evaluating the effects of potential anticancer antioxidants. While cancer cells often produce more ROS due to their increased growth-favoring demands, numerous conventional anticancer therapies exploit this feature to ensure selective cancer cell death triggered by excessive ROS levels, also causing serious side effects. The activation of the cellular NRF2 (nuclear factor erythroid 2 like 2) pathway and induction of cytoprotective genes accompanies an increase in ROS levels. A plethora of specific targets, including those involved in thioredoxin (TRX) and glutathione (GSH) systems, are activated by NRF2. 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Is oxidative stress dependent on tumour budding and inflammatory infiltration?. Cancers, 12.",{"doi":328},"10.3390\u002Fcancers12061636",{"id":21,"text":330,"url":21,"identifiers":331},"Harris, 2015, Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression, Cancer Cell, 27, 211, 10.1016\u002Fj.ccell.2014.11.019",{"doi":332},"10.1016\u002Fj.ccell.2014.11.019",{"id":21,"text":334,"url":21,"identifiers":335},"Jaganjac, 2016, Pathophysiology of neutrophil-mediated extracellular redox reactions, Front. Biosci. Landmark, 21, 839, 10.2741\u002F4423",{"doi":336},"10.2741\u002F4423",{"id":21,"text":338,"url":21,"identifiers":339},"Jaganjac, M., Milkovic, L., Gegotek, A., Cindric, M., Zarkovic, K., Skrzydlewska, E., and Zarkovic, N. (2019). The relevance of pathophysiological alterations in redox signaling of 4-hydroxynonenal for pharmacological therapies of major stress-associated diseases. Free Radic. Biol. 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Res., 47, 39, 10.3109\u002F10715762.2013.789136",{"doi":352},"10.3109\u002F10715762.2013.789136",{"id":21,"text":354,"url":21,"identifiers":355},"Zivkovic, 2005, Oxidative burst and anticancer activities of rat neutrophils, BioFactors, 24, 305, 10.1002\u002Fbiof.5520240136",{"doi":356},"10.1002\u002Fbiof.5520240136",{"id":21,"text":358,"url":21,"identifiers":359},"Zivkovic, 2007, Oxidative burst of neutrophils against melanoma B16-F10, Cancer Lett., 246, 100, 10.1016\u002Fj.canlet.2006.02.002",{"doi":360},"10.1016\u002Fj.canlet.2006.02.002",{"id":21,"text":362,"url":21,"identifiers":363},"Jaganjac, 2008, The involvement of granulocytes in spontaneous regression of Walker 256 carcinoma, Cancer Lett., 260, 180, 10.1016\u002Fj.canlet.2007.10.039",{"doi":364},"10.1016\u002Fj.canlet.2007.10.039",{"id":21,"text":366,"url":21,"identifiers":367},"Jaganjac, 2012, Elevated neutrophil elastase and acrolein-protein adducts are associated with W256 regression, Clin. Exp. 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A total of 144 three-week-old cockerels was divided into four experimental groups (n = 36 in each). Control feed was contaminated with STC or PSTC (1590 µg STC\u002Fkg or 1570.5 µg STC\u002Fkg feed), or with AFB1 (149.1 µg AFB1\u002Fkg feed). Six birds from each group were sampled at day 1, 2, 3, 7 and 14 of mycotoxin exposure. As parameters of lipid peroxidation, conjugated dienes (CD) and trienes (CT) were measured in the liver, while malondialdehyde (MDA) concentration was determined in blood plasma, red blood cell hemolysate and liver. Reduced glutathione (GSH) concentration and glutathione peroxidase (GPx) activity were determined in the same samples, and expression of glutathione peroxidase 4 (GPX4), glutathione synthetase (GSS) and glutathione reductase (GSR) genes was measured by RT-PCR in the liver. STC, PSTC or AFB1 caused a slight, but not significant, increase in CD and CT levels; however, in the case of MDA, no increase was found in the liver. Glutathione redox system was activated in the liver by AFB1, but less markedly by STC\u002FPSTC. PSTC and AFB1 resulted in a higher expression of GPX4, while GSS expression was down-regulated by AFB1 on day 1, but up-regulated by STC on day 2 and by both mycotoxins on day 7. However, on day 14, GSS expression was down-regulated by PSTC. Expression of GSR was low on day 1 in AFB1 and PSTC groups, but later it was up-regulated by AFB1. 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Toxicol., 7, 135, 10.1016\u002FS0015-6264(69)80295-6",{"doi":1907},"10.1016\u002FS0015-6264(69)80295-6",{"id":21,"text":1909,"url":21,"identifiers":1910},"Xing, 2005, Effects of sterigmatocystin on HLA- I expression of human peripheral blood mononuclear cells in vitro [In Chinese with English Abstract], Wei Sheng Yan Jiu, 34, 454",{},{"id":21,"text":1912,"url":21,"identifiers":1913},"Liu, 2012, Sterigmatocystin alters the number of FoxP3+ regulatory T cells and plasmacytoid dendritic cells in BALB\u002Fc mice, Food Chem. Toxicol., 50, 1920, 10.1016\u002Fj.fct.2012.03.005",{"doi":1914},"10.1016\u002Fj.fct.2012.03.005",{"id":21,"text":1916,"url":21,"identifiers":1917},"Zhang, 2012, Effects of sterigmatocystin on TNF-alpha, IL-6 and IL-12 expression in murine peripheral blood mononuclear cells and peritoneal macrophages in vivo, Mol. Med. Rep., 5, 1318",{},{"id":21,"text":1919,"url":21,"identifiers":1920},"Noda, 1981, Cytotoxic and mutagenic effects of sterigmatocystin on cultured Chinese hamster cells, Carcinogenesis, 2, 945, 10.1093\u002Fcarcin\u002F2.10.945",{"doi":1921},"10.1093\u002Fcarcin\u002F2.10.945",{"id":21,"text":1923,"url":21,"identifiers":1924},"Baertschi, 1989, Comparison of rates of enzymatic oxidation of aflatoxin B1, aflatoxin G1, and sterigmatocystin and activities of the epoxides in forming guanyl-N7 adducts and inducing different genetic responses, Chem. Res. Toxicol., 2, 114, 10.1021\u002Ftx00008a008",{"doi":1925},"10.1021\u002Ftx00008a008",{"id":21,"text":1927,"url":21,"identifiers":1928},"Curry, 1984, Induction of sister-chromatid exchanges in vivo in mice by the mycotoxins sterigmatocystin and griseofulvin, Mutat. 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Pharmacol., 60, 118, 10.1016\u002Fj.etap.2018.04.015",{"doi":2024},"10.1016\u002Fj.etap.2018.04.015",{"id":21,"text":2026,"url":21,"identifiers":2027},"Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method, Methods, 25, 402, 10.1006\u002Fmeth.2001.1262",{"doi":2028},"10.1006\u002Fmeth.2001.1262",{"id":21,"text":2030,"url":21,"identifiers":2031},"Lu, 2013, Glutathione synthesis, Biochim. Biophys. Acta, 1830, 3143, 10.1016\u002Fj.bbagen.2012.09.008",{"doi":2032},"10.1016\u002Fj.bbagen.2012.09.008",{"id":21,"text":2034,"url":21,"identifiers":2035},"Karaman, 2010, Pathological, biochemical and haematological investigations on the protective effect of alpha-lipoic acid in experimental aflatoxin toxicosis in chicks, Br. Poult. Sci., 51, 132, 10.1080\u002F00071660903401839",{"doi":2036},"10.1080\u002F00071660903401839",{"id":21,"text":2038,"url":21,"identifiers":2039},"Eraslan, 2004, Effects of aflatoxin and sodium bentonite administered in feed alone or combined on lipid peroxidation in the liver and kidneys of broilers, Bull. Vet. Inst. Pulawy, 48, 301",{},{"id":21,"text":2041,"url":21,"identifiers":2042},"Gowda, 2008, Efficacy of turmeric, containing a known level of curcumin, and a hydrated sodium calcium aluminosilicate to ameliorate the adverse effects of aflatoxin in broiler chicks, Poult. Sci., 87, 1125, 10.3382\u002Fps.2007-00313",{"doi":2043},"10.3382\u002Fps.2007-00313",{"id":21,"text":2045,"url":21,"identifiers":2046},"Huang, 2011, The selenium deficiency disease exudative diathesis in chicks is associated with down-regulation of seven common selenoprotein genes in liver and muscle, J. Nutr., 141, 1605, 10.3945\u002Fjn.111.145722",{"doi":2047},"10.3945\u002Fjn.111.145722",{"id":21,"text":2049,"url":21,"identifiers":2050},"Labunskyy, 2014, Selenoproteins: Molecular pathways and physiological roles, Physiol. Rev., 94, 739, 10.1152\u002Fphysrev.00039.2013",{"doi":2051},"10.1152\u002Fphysrev.00039.2013",{"id":21,"text":2053,"url":21,"identifiers":2054},"Purchase, 1970, Carcinogenicity of sterigmatocystin, Food Cosmet. Toxicol., 8, 289, 10.1016\u002FS0015-6264(70)80004-9",{"doi":2055},"10.1016\u002FS0015-6264(70)80004-9",{"id":21,"text":2057,"url":21,"identifiers":2058},"Sarma, 2008, Thiol cofactors for selenoenzymes and their synthetic mimics, Org. Biomol. Chem., 6, 965, 10.1039\u002Fb716239a",{"doi":2059},"10.1039\u002Fb716239a",{"id":2061,"createTime":2062,"updateTime":2063,"relativeEntities":2064,"slug":2065,"properties":2066,"entityType":151,"verifyStatus":152,"verifyTime":2062,"verifyNote":154,"languages":2082,"translateLanguages":2083,"viewCount":22,"primaryUrl":2084,"fullTextUrl":21,"authors":2085,"publicationType":233,"publisherRelationship":2260,"citationCount":122,"citationInfo":2328,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":2334,"openAccess":21,"references":2335,"isForceReanalyzing":1558},"507265a6-eb0f-4af1-b1a2-039fec138512","2024-08-09T05:28:26.814+00:00","2026-09-04T09:18:41.769+00:00",[],"Lipid-Peroxidation-Derived-Aldehydes-4-Hydroxynonenal-and-Malondialdehyde-in-Aging-Related-Disorders",{"mag":2067,"pmc":2069,"openalex":2071,"abstract":2073,"title":2075,"pm":2078,"doi":2080},{"VOID":2068},"2884618123",{"VOID":2070},"6115986",{"VOID":2072},"W2884618123",{"EN":2074},"\u003Cjats:p>Among the various mechanisms involved in aging, it was proposed long ago that a prominent role is played by oxidative stress. A major way by which the latter can provoke structural damage to biological macromolecules, such as DNA, lipids, and proteins, is by fueling the peroxidation of membrane lipids, leading to the production of several reactive aldehydes. Lipid peroxidation-derived aldehydes can not only modify biological macromolecules, by forming covalent electrophilic addition products with them, but also act as second messengers of oxidative stress, having relatively extended lifespans. Their effects might be further enhanced with aging, as their concentrations in cells and biological fluids increase with age. Since the involvement and the role of lipid peroxidation-derived aldehydes, particularly of 4-hydroxynonenal (HNE), in neurodegenerations, inflammation, and cancer, has been discussed in several excellent recent reviews, in the present one we focus on the involvement of reactive aldehydes in other age-related disorders: osteopenia, sarcopenia, immunosenescence and myelodysplastic syndromes. In these aging-related disorders, characterized by increases of oxidative stress, both HNE and malondialdehyde (MDA) play important pathogenic roles. These aldehydes, and HNE in particular, can form adducts with circulating or cellular proteins of critical functional importance, such as the proteins involved in apoptosis in muscle cells, thus leading to their functional decay and acceleration of their molecular turnover and functionality. We suggest that a major fraction of the toxic effects observed in age-related disorders could depend on the formation of aldehyde-protein adducts. New redox proteomic approaches, pinpointing the modifications of distinct cell proteins by the aldehydes generated in the course of oxidative stress, should be extended to these age-associated disorders, to pave the way to targeted therapeutic strategies, aiming to alleviate the burden of morbidity and mortality associated with these disturbances.\u003C\u002Fjats:p>",{"EN":2076,"VI":2077},"Lipid Peroxidation-Derived Aldehydes, 4-Hydroxynonenal and Malondialdehyde in Aging-Related Disorders","Các aldehyde có nguồn gốc từ quá trình peroxy hóa lipid, 4-Hydroxynonenal và malondialdehyde trong các rối loạn liên quan đến lão hóa",{"VOID":2079},"30061536",{"VOID":2081},"10.3390\u002Fantiox7080102",[156],[158],"https:\u002F\u002Fwww.mdpi.com\u002F2076-3921\u002F7\u002F8\u002F102",[2086,2105,2122,2139,2158,2177,2192,2211,2226,2243],{"id":2087,"sortIndex":22,"researcher":21,"roles":2088,"affiliations":2089,"properties":2098,"displayName":2102,"givenName":21,"familyName":21},"c9b7d650-a871-4fcc-aa35-d5868643f52d",[],[2090],{"id":2091,"sortIndex":22,"affiliation":2092,"properties":21},"b7828f50-1f8b-428a-835c-c8a6363b41a8",{"id":2091,"createTime":21,"updateTime":21,"relativeEntities":2093,"slug":21,"properties":2094,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":2097,"statistic":21},[],{"title":2095},{"EN":2096},"Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, 10124 Turin, Italy",[],{"orcid":2099,"title":2101,"openalex":2103},{"VOID":2100},"https:\u002F\u002Forcid.org\u002F0000-0002-8587-4166",{"EN":2102},"Giuseppina Barrera",{"VOID":2104},"A5066492622",{"id":2106,"sortIndex":120,"researcher":21,"roles":2107,"affiliations":2108,"properties":2115,"displayName":2119,"givenName":21,"familyName":21},"22275914-62e6-4bbe-bd2c-3f7c18db3a57",[],[2109],{"id":2091,"sortIndex":22,"affiliation":2110,"properties":21},{"id":2091,"createTime":21,"updateTime":21,"relativeEntities":2111,"slug":21,"properties":2112,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":2114,"statistic":21},[],{"title":2113},{"EN":2096},[],{"orcid":2116,"title":2118,"openalex":2120},{"VOID":2117},"https:\u002F\u002Forcid.org\u002F0000-0001-6937-8632",{"EN":2119},"Stefania Pizzimenti",{"VOID":2121},"A5043387826",{"id":2123,"sortIndex":199,"researcher":21,"roles":2124,"affiliations":2125,"properties":2132,"displayName":2136,"givenName":21,"familyName":21},"d233ba36-ae4a-4613-96d8-67ac20656a47",[],[2126],{"id":2091,"sortIndex":22,"affiliation":2127,"properties":21},{"id":2091,"createTime":21,"updateTime":21,"relativeEntities":2128,"slug":21,"properties":2129,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":2131,"statistic":21},[],{"title":2130},{"EN":2096},[],{"orcid":2133,"title":2135,"openalex":2137},{"VOID":2134},"https:\u002F\u002Forcid.org\u002F0000-0001-7377-7847",{"EN":2136},"Martina Daga",{"VOID":2138},"A5002931385",{"id":2140,"sortIndex":217,"researcher":21,"roles":2141,"affiliations":2142,"properties":2151,"displayName":2155,"givenName":21,"familyName":21},"4c51e109-7552-446b-9b30-17c9d55739a2",[],[2143],{"id":2144,"sortIndex":22,"affiliation":2145,"properties":21},"dd6c920a-e75e-48d3-805d-4421b6caad06",{"id":2144,"createTime":21,"updateTime":21,"relativeEntities":2146,"slug":21,"properties":2147,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":2150,"statistic":21},[],{"title":2148},{"EN":2149},"Dipartimento di Scienze e Tecnologia del Farmaco, Università di Torino, 10124 Turin, Italy",[],{"orcid":2152,"title":2154,"openalex":2156},{"VOID":2153},"https:\u002F\u002Forcid.org\u002F0000-0002-2246-3183",{"EN":2155},"Chiara Dianzani",{"VOID":2157},"A5035082629",{"id":2159,"sortIndex":1665,"researcher":21,"roles":2160,"affiliations":2161,"properties":2170,"displayName":2174,"givenName":21,"familyName":21},"29ca46ec-b96c-4aee-b995-ac08e75644ed",[],[2162],{"id":2163,"sortIndex":22,"affiliation":2164,"properties":21},"ff3ea208-6a0b-4298-9d7f-d8d41c5c76b0",{"id":2163,"createTime":21,"updateTime":21,"relativeEntities":2165,"slug":21,"properties":2166,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":2169,"statistic":21},[],{"title":2167},{"EN":2168},"Dipartimento di Medicina e Scienze della Salute \"V. 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Current status and trends in the diagnostics of AML and MDS. Blood Rev.",{"doi":2650},"10.1016\u002Fj.blre.2018.04.008",{"id":21,"text":2652,"url":21,"identifiers":2653},"Malcovati, 2005, Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: A basis for clinical decision-making, J. Clin. Oncol., 23, 7594, 10.1200\u002FJCO.2005.01.7038",{"doi":2654},"10.1200\u002FJCO.2005.01.7038",{"id":21,"text":2656,"url":21,"identifiers":2657},"Farquhar, 2003, Oxidative stress and the myelodysplastic syndromes, Int. J. Hematol., 77, 342, 10.1007\u002FBF02982641",{"doi":2658},"10.1007\u002FBF02982641",{"id":21,"text":2660,"url":21,"identifiers":2661},"Barbosa, 2013, Increased parameters of oxidative stress and its relation to transfusion iron overload in patients with myelodysplastic syndromes, J. Clin. 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Hung., 102, 400, 10.1556\u002F036.102.2015.4.7",{"doi":2720},"10.1556\u002F036.102.2015.4.7",{"id":21,"text":2722,"url":21,"identifiers":2723},"Esfahani, 2012, Influence of chemotherapy on the lipid peroxidation and antioxidant status in patients with acute myeloid leukemia, Acta Med. Iran., 50, 454",{},{"id":21,"text":2725,"url":21,"identifiers":2726},"Brioche, 2016, Oxidative Stress, Sarcopenia, Antioxidant Strategies and Exercise: Molecular Aspects, Curr. Pharm. Des., 22, 2664, 10.2174\u002F1381612822666160219120531",{"doi":2727},"10.2174\u002F1381612822666160219120531",{"id":21,"text":2729,"url":21,"identifiers":2730},"Espino, 2012, Oxidative stress and immunosenescence: Therapeutic effects of melatonin, Oxid. Med. Cell. Longev., 2012, 670294, 10.1155\u002F2012\u002F670294",{"doi":2731},"10.1155\u002F2012\u002F670294",{"id":2733,"createTime":2734,"updateTime":2734,"relativeEntities":2735,"slug":2736,"properties":2737,"entityType":151,"verifyStatus":152,"verifyTime":2744,"verifyNote":154,"languages":2745,"translateLanguages":21,"viewCount":22,"primaryUrl":2746,"fullTextUrl":21,"authors":2747,"publicationType":233,"publisherRelationship":2881,"citationCount":2951,"citationInfo":2952,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":2956,"openAccess":21,"references":2957,"isForceReanalyzing":1558},"f94a1db7-70c7-4f97-83f6-9c911644ab06","2026-04-01T15:01:38.220+00:00",[],"Clove-Essential-Oil-Chemical-Profile-Biological-Activities-Encapsulation-Strategies-and-Food-Applications",{"title":2738,"doi":2740,"abstract":2742},{"EN":2739},"Clove Essential Oil: Chemical Profile, Biological Activities, Encapsulation Strategies, and Food Applications",{"VOID":2741},"10.3390\u002Fantiox13040488",{"EN":2743},"Plants have proven to be important sources for discovering new compounds that are useful in the treatment of various diseases due to their phytoconstituents. Clove (Syzygium aromaticum L.), an aromatic plant widely cultivated around the world, has been traditionally used for food preservation and medicinal purposes. In particular, clove essential oil (CEO) has attracted attention for containing various bioactive compounds, such as phenolics (eugenol and eugenol acetate), terpenes (β-caryophyllene and α-humulene), and hydrocarbons. These constituents have found applications in cosmetics, food, and medicine industries due to their bioactivity. Pharmacologically, CEO has been tested against a variety of parasites and pathogenic microorganisms, demonstrating antibacterial and antifungal properties. Additionally, many studies have also demonstrated the analgesic, antioxidant, anticancer, antiseptic, and anti-inflammatory effects of this essential oil. However, CEO could degrade for different reasons, impacting its quality and bioactivity. To address this challenge, encapsulation is viewed as a promising strategy that could prolong the shelf life of CEO, improving its physicochemical stability and application in various areas. This review examines the phytochemical composition and biological activities of CEO and its constituents, as well as extraction methods to obtain it. Moreover, encapsulation strategies for CEO and numerous applications in different food fields are also highlighted.","2026-04-01T15:01:38.218+00:00",[156],"https:\u002F\u002Fwww.mdpi.com\u002F2076-3921\u002F13\u002F4\u002F488",[2748,2767,2786,2803,2822,2839,2856],{"id":2749,"sortIndex":22,"researcher":21,"roles":2750,"affiliations":2751,"properties":2760,"displayName":2764,"givenName":21,"familyName":21},"b0e50982-9a00-4c2a-a25b-83f96dd8ddfd",[],[2752],{"id":2753,"sortIndex":22,"affiliation":2754,"properties":21},"f88964ef-5496-4a77-bb43-a11c7b2889b1",{"id":2753,"createTime":21,"updateTime":21,"relativeEntities":2755,"slug":21,"properties":2756,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":2759,"statistic":21},[],{"title":2757},{"EN":2758},"Department of Organic Chemistry, Faculty of Chemical Sciences and Technologies, University of Castilla-La Mancha, 13071 Ciudad Real, 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It is a major component of the Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diets. Phytate is recognized as a nutraceutical and is classified by the Food and Drug Administration (FDA) as Generally Recognized As Safe (GRAS). Phytate has been shown to be effective in treating or preventing certain diseases. Phytate has been shown to inhibit calcium salt crystallization and, therefore, to reduce vascular calcifications, calcium renal calculi and soft tissue calcifications. Moreover, the adsorption of phytate to the crystal faces can inhibit hydroxyapatite dissolution and bone resorption, thereby playing a role in the treatment\u002Fprevention of bone mass loss. Phytate has a potent antioxidation and anti-inflammatory action. It is capable of inhibiting lipid peroxidation through iron chelation, reducing iron-related free radical generation. As this has the effect of mitigating neuronal damage and loss, phytate shows promise in the treatment\u002Fprevention of neurodegenerative disease. It is reported that phytate improves lipid and carbohydrate metabolism, increases adiponectin, decreases leptin and reduces protein glycation, which is linked with macrovascular and microvascular diabetes complications. In this review, we summarize the benefits of phytate intake as seen in in vitro, animal model, epidemiological and clinical trials, and we also identify questions to answer in the future.\u003C\u002Fjats:p>",{"EN":3859},"Phytate Intake, Health and Disease: “Let Thy Food Be Thy Medicine and Medicine Be Thy Food”",{"VOID":3861},"36671007",{"VOID":3863},"10.3390\u002Fantiox12010146","2025-02-03T12:22:17.489+00:00",[156],"https:\u002F\u002Fwww.mdpi.com\u002F2076-3921\u002F12\u002F1\u002F146",[3868,3887,3906,3923],{"id":3869,"sortIndex":22,"researcher":21,"roles":3870,"affiliations":3871,"properties":3880,"displayName":3884,"givenName":21,"familyName":21},"9cbdf602-049c-4f69-982a-2b2000fb79fa",[],[3872],{"id":3873,"sortIndex":22,"affiliation":3874,"properties":21},"5f7c1a98-dd88-4e50-aa2d-bfe622360d85",{"id":3873,"createTime":21,"updateTime":21,"relativeEntities":3875,"slug":21,"properties":3876,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":3879,"statistic":21},[],{"title":3877},{"EN":3878},"Vascular and Metabolic Diseases Research Group, Endocrinology Department, Son Llàtzer University Hospital, Health Research Institute of the Balearic Islands (IdISBa), 07198 Palma de Mallorca, Spain",[],{"orcid":3881,"title":3883,"openalex":3885},{"VOID":3882},"https:\u002F\u002Forcid.org\u002F0000-0002-4579-4620",{"EN":3884},"Antelm Pujol",{"VOID":3886},"A5087669091",{"id":3888,"sortIndex":120,"researcher":21,"roles":3889,"affiliations":3890,"properties":3899,"displayName":3903,"givenName":21,"familyName":21},"4ad8977d-0ad9-4735-ad24-312e6385f791",[],[3891],{"id":3892,"sortIndex":22,"affiliation":3893,"properties":21},"fb7ded7a-9648-40a9-9216-f2cf0bdd086b",{"id":3892,"createTime":21,"updateTime":21,"relativeEntities":3894,"slug":21,"properties":3895,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":3898,"statistic":21},[],{"title":3896},{"EN":3897},"Laboratory of Renal Lithiasis Research, Deptartment of Chemistry, University of Balearic Islands, Health Research Institute of Balearic Islands, (IdISBa), 07122 Palma de Mallorca, Spain",[],{"orcid":3900,"title":3902,"openalex":3904},{"VOID":3901},"https:\u002F\u002Forcid.org\u002F0000-0001-8565-1811",{"EN":3903},"Pilar Sanchís",{"VOID":3905},"A5044614490",{"id":3907,"sortIndex":199,"researcher":21,"roles":3908,"affiliations":3909,"properties":3916,"displayName":3920,"givenName":21,"familyName":21},"6347fb63-3077-42a4-b52e-6146b084fb5c",[],[3910],{"id":3892,"sortIndex":22,"affiliation":3911,"properties":21},{"id":3892,"createTime":21,"updateTime":21,"relativeEntities":3912,"slug":21,"properties":3913,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":3915,"statistic":21},[],{"title":3914},{"EN":3897},[],{"orcid":3917,"title":3919,"openalex":3921},{"VOID":3918},"https:\u002F\u002Forcid.org\u002F0000-0001-5636-9139",{"EN":3920},"F. 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Nutr., 68, 1123, 10.1093\u002Fajcn\u002F68.5.1123",{"doi":4772},"10.1093\u002Fajcn\u002F68.5.1123",{"id":21,"text":4774,"url":21,"identifiers":4775},"Mendoza, 2001, Absorption of iron from unmodified maize and genetically altered, low-phytate maize fortified with ferrous sulfate or sodium iron EDTA, Am. J. Clin. Nutr., 73, 80, 10.1093\u002Fajcn\u002F73.1.80",{"doi":4776},"10.1093\u002Fajcn\u002F73.1.80",{"id":21,"text":4778,"url":21,"identifiers":4779},"Grases, 2001, Dietary phytate and mineral bioavailability, J. Trace Elements Med. Biol., 15, 221, 10.1016\u002FS0946-672X(01)80037-7",{"doi":4780},"10.1016\u002FS0946-672X(01)80037-7",{"id":21,"text":4782,"url":21,"identifiers":4783},"Cullumbine, 1950, Mineral Metabolism on Rice Diets, Br. J. Nutr., 4, 101, 10.1079\u002FBJN19500025",{"doi":4784},"10.1079\u002FBJN19500025",{"id":21,"text":4786,"url":21,"identifiers":4787},"Walker, 1948, Studies in human mineral metabolism: 1. The effect of bread rich in phytate phosphorus on the metabolism of certain mineral salts with special reference to calcium, Biochem. J., 42, 452, 10.1042\u002Fbj0420452",{"doi":4788},"10.1042\u002Fbj0420452",{"id":21,"text":4790,"url":21,"identifiers":4791},"Grases, 2018, Evaluation of inositol phosphates in urine after topical administration of myo-inositol hexaphosphate to female Wistar rats, Life Sci., 192, 33, 10.1016\u002Fj.lfs.2017.11.023",{"doi":4792},"10.1016\u002Fj.lfs.2017.11.023",{"id":21,"text":4794,"url":21,"identifiers":4795},"Grases, 2000, Inositol hexakisphosphate in urine: The relationship between oral intake and urinary excretion, Br. J. Urol., 85, 138, 10.1046\u002Fj.1464-410x.2000.00324.x",{"doi":4796},"10.1046\u002Fj.1464-410x.2000.00324.x",{"id":21,"text":4798,"url":21,"identifiers":4799},"Grases, 2001, Absorption and excretion of orally administered inositol hexaphosphate (IP6or phytate) in humans, BioFactors, 15, 53, 10.1002\u002Fbiof.5520150105",{"doi":4800},"10.1002\u002Fbiof.5520150105",{"id":21,"text":4802,"url":21,"identifiers":4803},"Schlemmer, 2009, Phytate in foods and significance for humans: Food sources, intake, processing, bioavailability, protective role and analysis, Mol. Nutr. Food Res., 53, S330, 10.1002\u002Fmnfr.200900099",{"doi":4804},"10.1002\u002Fmnfr.200900099",{"id":21,"text":4806,"url":21,"identifiers":4807},"Grases, 2001, Variation of InsP4,InsP5 and InsP6 levels in tissues and biological fluids depending on dietary phytate, J. Nutr. Biochem., 12, 595, 10.1016\u002FS0955-2863(01)00178-4",{"doi":4808},"10.1016\u002FS0955-2863(01)00178-4",{"id":4810,"createTime":4811,"updateTime":4811,"relativeEntities":4812,"slug":4813,"properties":4814,"entityType":151,"verifyStatus":152,"verifyTime":4811,"verifyNote":154,"languages":4829,"translateLanguages":21,"viewCount":22,"primaryUrl":4830,"fullTextUrl":21,"authors":4831,"publicationType":233,"publisherRelationship":4923,"citationCount":4992,"citationInfo":4993,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":4995,"openAccess":21,"references":4996,"isForceReanalyzing":1558},"10615b16-8c0c-4569-90de-a74f5e2de140","2025-01-29T03:36:24.182+00:00",[],"Antioxidant-Content-Antioxidant-Activity-and-Antibacterial-Activity-of-Five-Plants-from-the-Commelinaceae-Family",{"mag":4815,"pmc":4817,"openalex":4819,"abstract":4821,"title":4823,"pm":4825,"doi":4827},{"VOID":4816},"2048993587",{"VOID":4818},"4665499",{"VOID":4820},"W2048993587",{"EN":4822},"\u003Cjats:p>Commelinaceae is a family of herbaceous flowering plants with many species used in ethnobotany, particularly in South America. However, thus far reports of their bioactivity are few and far between. The primary aim of this study was to quantify the antioxidant and antibacterial activity of five Commelinaceae methanolic leaf extracts. The antioxidant content was evaluated by the total phenolic content (TPC), total tannin content (TTC), and total flavonoid content (TFC) assays. The antioxidant activities measured were DPPH free radical scavenging (FRS), ferric reducing power (FRP), and ferrous ion chelating (FIC); of the five plants, the methanolic leaf extract of Tradescantia zebrina showed the highest antioxidant content and activity, and exhibited antibacterial activity against six species of Gram-positive and two species of Gram-negative bacteria in a range of 5–10 mg\u002FmL based on the broth microdilution method.\u003C\u002Fjats:p>",{"EN":4824},"Antioxidant Content, Antioxidant Activity, and Antibacterial Activity of Five Plants from the Commelinaceae 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1999, Distribution of calcium oxalate crystals in some Nigerian species of Aneilema R. Br. (Commelinaceae), Plant Biosyst., 133, 193, 10.1080\u002F11263509909381548",{"doi":5000},"10.1080\u002F11263509909381548",{"id":21,"text":5002,"url":21,"identifiers":5003},"Satterfield, 1972, Rhoeo spathacea: A tool for teaching meiosis and mitosis, J. Hered., 63, 375, 10.1093\u002Foxfordjournals.jhered.a108321",{"doi":5004},"10.1093\u002Foxfordjournals.jhered.a108321",{"id":21,"text":5006,"url":21,"identifiers":5007},"Kubitzki, 1998, Commelinaceae, Flowering Plants—Monocotyledons, Volume 4, 109",{},{"id":21,"text":5009,"url":21,"identifiers":5010},"Wilson, 1981, Commelinaceae—A review of the distribution, biology and control of the important weeds belonging to this family, Trop. Pest Manag., 27, 405, 10.1080\u002F09670878109413812",{"doi":5011},"10.1080\u002F09670878109413812",{"id":21,"text":5013,"url":21,"identifiers":5014},"2003, Antigenotoxic, antimutagenic and ROS scavenging activities of a Rhoeo discolor ethanolic crude extract, Toxicol. In Vitro, 17, 77, 10.1016\u002FS0887-2333(02)00120-0",{"doi":5015},"10.1016\u002FS0887-2333(02)00120-0",{"id":21,"text":5017,"url":21,"identifiers":5018},"Blasco, 2011, Antimutagenicity mechanisms of the Rhoeo discolor ethanolic extract, Exp. Toxicol. Pathol., 63, 243, 10.1016\u002Fj.etp.2010.01.001",{"doi":5019},"10.1016\u002Fj.etp.2010.01.001",{"id":21,"text":5021,"url":21,"identifiers":5022},"Mensah, 2006, In vitro evaluation of effects of two Ghanaian plants relevant to wound healing, Phytother. Res., 20, 941, 10.1002\u002Fptr.1978",{"doi":5023},"10.1002\u002Fptr.1978",{"id":21,"text":5025,"url":21,"identifiers":5026},"Villarreal, 2011, Mexican medicinal plants used for cancer treatment: Pharmacological, phytochemical and ethnobotanical studies, J. Ethnopharmacol., 133, 945, 10.1016\u002Fj.jep.2010.11.055",{"doi":5027},"10.1016\u002Fj.jep.2010.11.055",{"id":21,"text":5029,"url":21,"identifiers":5030},"Grachev, 2009, An overview of silica in biology: Its chemistry and recent technological advances, Biosilica in Evolution, Morphogenesis, and Nanobiotechnology, Volume 47, 295, 10.1007\u002F978-3-540-88552-8_13",{"doi":5031},"10.1007\u002F978-3-540-88552-8_13",{"id":21,"text":5033,"url":21,"identifiers":5034},"Tan, J.B.L., Lim, Y.Y., and Lee, S.M. (2013). Antioxidant and antibacterial activity of Rhoeo spathacea (Swartz) Stearn leaves. J. Food Sci. Technol.",{"doi":5035},"10.1007\u002Fs13197-013-1236-z",{"id":21,"text":5037,"url":21,"identifiers":5038},"Xeriscape Plants. Available online:http:\u002F\u002Fwww.ctahr.hawaii.edu\u002Foc\u002Ffreepubs\u002Fpdf\u002FOF-42.pdf.",{},{"id":21,"text":5040,"url":21,"identifiers":5041},"Golczyk, 2011, Cytogenetics of the permanent translocation heterozygote Rhoeo spathacea var. variegata. Implications for complex chromosome rearrangements in Rhoeo, Caryologia, 64, 325, 10.1080\u002F00087114.2011.10589799",{"doi":5042},"10.1080\u002F00087114.2011.10589799",{"id":21,"text":5044,"url":21,"identifiers":5045},"Paiva, 2003, The influence of light intensity on anatomical structure and pigment contents of Tradescantia pallida (Rose) Hunt. cv. purpurea Boom (Commelinaceae) leaves, Braz. Arch. Biol. Technol., 46, 617, 10.1590\u002FS1516-89132003000400017",{"doi":5046},"10.1590\u002FS1516-89132003000400017",{"id":21,"text":5048,"url":21,"identifiers":5049},"Rainho, 2010, Ability of Allium cepa L. root tips and Tradescantia pallida var. purpurea in N-nitrosodiethylamine genotoxicity and mutagenicity evaluation, An. Acad. Bras. 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CRC Press.",{},{"id":21,"text":5067,"url":21,"identifiers":5068},"Faden, 2008, The author and typification of Tradescantia zebrina (Commelinaceae), Kew Bull., 63, 679, 10.1007\u002Fs12225-008-9078-y",{"doi":5069},"10.1007\u002Fs12225-008-9078-y",{"id":21,"text":5071,"url":21,"identifiers":5072},"Yanzhi, 2009, Pigment content and anatomical structure of leaves of several species of red-leafed plants, J. N. E. Forest. Univ., 37, 51",{},{"id":21,"text":5074,"url":21,"identifiers":5075},"Glimn-Lacy, J., and Kaufman, P.B. (2006). Botany Illustrated, Springer US.",{},{"id":21,"text":5077,"url":21,"identifiers":5078},"Amaral, 2006, Plants and chemical constituents with giardicidal activity, Braz. J. Pharmacog., 16, 696, 10.1590\u002FS0102-695X2006000500017",{"doi":5079},"10.1590\u002FS0102-695X2006000500017",{"id":21,"text":5081,"url":21,"identifiers":5082},"Reina, 2012, Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants, Parasitol. 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J. Phys. Chem. B, 4, 797, 10.1134\u002FS1990793110050167",{"doi":5099},"10.1134\u002FS1990793110050167",{"id":21,"text":5101,"url":21,"identifiers":5102},"Olennikov, 2008, Chemical composition of Callisia fragrans wood. juice and its antioxidative activity (in vitro), Chem. Plant Raw Mater., 4, 95",{},{"id":21,"text":5104,"url":21,"identifiers":5105},"Malaysian Meteorological Department. Available online:http:\u002F\u002Fwww.met.gov.my\u002Findex.php?option=com_content&task=view&id=34&Itemid=1586.",{},{"id":21,"text":5107,"url":21,"identifiers":5108},"Hopia, 1999, Antioxidant activity of plant extracts containing phenolic compounds, J. Agric. 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Ethnopharmacol., 111, 63, 10.1016\u002Fj.jep.2006.10.032",{"doi":5164},"10.1016\u002Fj.jep.2006.10.032",{"id":5166,"createTime":5167,"updateTime":5167,"relativeEntities":5168,"slug":5169,"properties":5170,"entityType":151,"verifyStatus":152,"verifyTime":5185,"verifyNote":154,"languages":5186,"translateLanguages":21,"viewCount":22,"primaryUrl":5187,"fullTextUrl":21,"authors":5188,"publicationType":233,"publisherRelationship":5261,"citationCount":5330,"citationInfo":5331,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":5335,"openAccess":21,"references":5336,"isForceReanalyzing":1558},"f37b674f-000b-403d-acf2-acd38d2e72f3","2025-01-23T06:43:19.660+00:00",[],"Modulation-of-Autophagy-in-Cancer-Cells-by-Dietary-Polyphenols",{"mag":5171,"pmc":5173,"openalex":5175,"abstract":5177,"title":5179,"pm":5181,"doi":5183},{"VOID":5172},"3120593900",{"VOID":5174},"7830598",{"VOID":5176},"W3120593900",{"EN":5178},"\u003Cjats:p>The role of autophagy is to degrade damaged or unnecessary cellular structures. 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This review presents in vitro and in vivo studies in animal models with the use of polyphenolic compounds such as epigallocatechin-3-gallate (EGCG), oleuropein, punicalgin, apigenin, resveratrol, pterostilbene, or curcumin and their importance in the modulation of autophagy-induced death of cancer cells.\u003C\u002Fjats:p>",{"EN":5180},"Modulation of Autophagy in Cancer Cells by Dietary 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Antioxidants, 8.",{"doi":5905},"10.3390\u002Fantiox8090382",{"id":5907,"createTime":5908,"updateTime":5908,"relativeEntities":5909,"slug":5910,"properties":5911,"entityType":151,"verifyStatus":152,"verifyTime":5926,"verifyNote":154,"languages":5927,"translateLanguages":21,"viewCount":22,"primaryUrl":5928,"fullTextUrl":21,"authors":5929,"publicationType":233,"publisherRelationship":6030,"citationCount":6099,"citationInfo":6100,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":6105,"openAccess":21,"references":6106,"isForceReanalyzing":1558},"a399eda2-2ecc-487e-971d-24e372323817","2025-01-02T18:36:59.126+00:00",[],"Medicinal-Profile-Phytochemistry-and-Pharmacological-Activities-of-Murraya-koenigii-and-its-Primary-Bioactive-Compounds",{"mag":5912,"pmc":5914,"openalex":5916,"abstract":5918,"title":5920,"pm":5922,"doi":5924},{"VOID":5913},"3002772832",{"VOID":5915},"7070712",{"VOID":5917},"W3002772832",{"EN":5919},"\u003Cjats:p>The discovery of several revitalizing molecules that can stop or reduce the pathology of a wide range of diseases will be considered a major breakthrough of the present time. Available synthetic compounds may provoke side effects and health issues, which heightens the need for molecules from plants and other natural resources under discovery as potential methods of replacing synthetic compounds. In traditional medicinal therapies, several plant extracts and phytochemicals have been reported to impart remedial effects as better alternatives. Murraya koenigii (M. koenigii) belongs to the Rutaceae family, which is commonly used as a medicinally important herb of Indian origin in the Ayurvedic system of medicine. Previous reports have demonstrated that the leaves, roots, and bark of this plant are rich sources of carbazole alkaloids, which produce potent biological activities and pharmacological effects. These include antioxidant, antidiabetic, anti-inflammatory, antitumor, and neuroprotective activities. The present review provides insight into the major components of M. koenigii and their pharmacological activities against different pathological conditions. The review also emphasizes the need for more research on the molecular basis of such activity in various cellular and animal models to validate the efficacy of M. koenigii and its derivatives as potent therapeutic agents.\u003C\u002Fjats:p>",{"EN":5921},"Medicinal Profile, Phytochemistry, and Pharmacological Activities of Murraya koenigii and its Primary Bioactive Compounds",{"VOID":5923},"31991665",{"VOID":5925},"10.3390\u002Fantiox9020101","2025-01-02T18:36:59.125+00:00",[156],"https:\u002F\u002Fwww.mdpi.com\u002F2076-3921\u002F9\u002F2\u002F101",[5930,5949,5966,5981,5998,6013],{"id":5931,"sortIndex":22,"researcher":21,"roles":5932,"affiliations":5933,"properties":5942,"displayName":5946,"givenName":21,"familyName":21},"e40c2d6f-e66b-45ec-830d-b9d5cbb10408",[],[5934],{"id":5935,"sortIndex":22,"affiliation":5936,"properties":21},"595cea97-3b69-4136-806c-0b0cf241602d",{"id":5935,"createTime":21,"updateTime":21,"relativeEntities":5937,"slug":21,"properties":5938,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":5941,"statistic":21},[],{"title":5939},{"EN":5940},"Department of Applied Life Sciences and Integrated Bioscience, Graduate School, Konkuk University, Chungju 27478, Korea.",[],{"orcid":5943,"title":5945,"openalex":5947},{"VOID":5944},"https:\u002F\u002Forcid.org\u002F0000-0001-8135-8183",{"EN":5946},"Rengasamy Balakrishnan",{"VOID":5948},"A5113710900",{"id":5950,"sortIndex":120,"researcher":21,"roles":5951,"affiliations":5952,"properties":5961,"displayName":5963,"givenName":21,"familyName":21},"bec778a4-3f88-4349-99eb-77b65bad12f9",[],[5953],{"id":5954,"sortIndex":22,"affiliation":5955,"properties":21},"aa85cd50-8b98-45f1-9339-fbd482491166",{"id":5954,"createTime":21,"updateTime":21,"relativeEntities":5956,"slug":21,"properties":5957,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":5960,"statistic":21},[],{"title":5958},{"EN":5959},"Department of Biochemistry, Rev. 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A total number of 35 male Wistar albino rats were divided equally into five groups. Group 1 served as control and received normal saline intraperitoneally. Group 2, the sham group, were administered only corn oil (vehicle of malathion) orally. Group 3 was orally intoxicated by malathion in corn oil at a dose of 135 mg\u002Fkg BW via intra-gastric gavage. Group 4 received malathion orally concomitantly with Ornipural® intraperitoneally. Group 5 was given Ornipural® solution in saline via intraperitoneal injection at a dose of (1 mL\u002Fkg BW). Animals received the treatment regime for 30 days. Histopathological examination revealed the harmful effect of malathion on hepatic and renal tissue. The results showed that malathion induced a significant decrease in body weight and marked elevation in the activity of liver enzymes, LDH, and ACP. In contrast, the activity of AchE and Paraoxonase was markedly decreased. Moreover, there was a significant increase in the serum content of bilirubin, cholesterol, and kidney injury markers. A significant elevation in malondialdehyde, nitric oxide (nitrite), and 8-hydroxy-2-deoxyguanosine was observed, along with a substantial reduction in antioxidant activity. Furthermore, malathion increased tumor necrosis factor-alpha, the upregulation of IL-1B, BAX, and IFN-β genes, and the downregulation of Nrf2, Bcl2, and HO-1 genes. Concurrent administration of Ornipural® with malathion attenuated the detrimental impact of malathion through ameliorating metabolic biomarkers, restoring antioxidant activity, reducing the inflammatory response, and improving pathologic microscopic alterations. It could be concluded that Ornipural® solution demonstrates hepatorenal defensive impacts against malathion toxicity at biochemical, antioxidants, molecular, and cellular levels.\u003C\u002Fjats:p>",{"EN":6578},"Ornipural® Mitigates Malathion-Induced Hepato-Renal Damage in Rats via Amelioration of Oxidative Stress Biomarkers, Restoration of Antioxidant Activity, and Attenuation of Inflammatory Response",{"VOID":6580},"35453442",{"VOID":6582},"10.3390\u002Fantiox11040757",[156],"https:\u002F\u002Fwww.mdpi.com\u002F2076-3921\u002F11\u002F4\u002F757",[6586,6605,6624,6643,6662,6681,6700],{"id":6587,"sortIndex":22,"researcher":21,"roles":6588,"affiliations":6589,"properties":6598,"displayName":6602,"givenName":21,"familyName":21},"5604b766-1731-4923-aba1-effcb5e917e1",[],[6590],{"id":6591,"sortIndex":22,"affiliation":6592,"properties":21},"dc107716-7e07-40cd-9e1c-593707b5b22f",{"id":6591,"createTime":21,"updateTime":21,"relativeEntities":6593,"slug":21,"properties":6594,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":6597,"statistic":21},[],{"title":6595},{"EN":6596},"Departement of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Alexandria University, Alexandria 22758, Egypt",[],{"orcid":6599,"title":6601,"openalex":6603},{"VOID":6600},"https:\u002F\u002Forcid.org\u002F0000-0002-6882-5098",{"EN":6602},"Osama S. 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J., 2, 677, 10.1136\u002Fbmj.2.5097.677",{"doi":7121},"10.1136\u002Fbmj.2.5097.677",{"id":7123,"createTime":7124,"updateTime":7124,"relativeEntities":7125,"slug":7126,"properties":7127,"entityType":151,"verifyStatus":152,"verifyTime":7142,"verifyNote":154,"languages":7143,"translateLanguages":21,"viewCount":22,"primaryUrl":7144,"fullTextUrl":21,"authors":7145,"publicationType":233,"publisherRelationship":7248,"citationCount":7317,"citationInfo":7318,"publishDate":21,"publishYear":21,"citationAnalyzeStatus":20,"lastCitationAnalyze":21,"indexDatabases":7326,"openAccess":21,"references":7327,"isForceReanalyzing":1558},"738fdab0-0de9-42f3-8996-5497d32c1913","2024-12-29T13:20:46.979+00:00",[],"Zinc-and-Oxidative-Stress-Current-Mechanisms",{"mag":7128,"pmc":7130,"openalex":7132,"abstract":7134,"title":7136,"pm":7138,"doi":7140},{"VOID":7129},"2598259733",{"VOID":7131},"5488004",{"VOID":7133},"W2598259733",{"EN":7135},"\u003Cjats:p>Oxidative stress is a metabolic dysfunction that favors the oxidation of biomolecules, contributing to the oxidative damage of cells and tissues. This consequently contributes to the development of several chronic diseases. In particular, zinc is one of the most relevant minerals to human health, because of its antioxidant properties. This review aims to provide updated information about the mechanisms involved in the protective role of zinc against oxidative stress. Zinc acts as a co-factor for important enzymes involved in the proper functioning of the antioxidant defense system. In addition, zinc protects cells against oxidative damage, acts in the stabilization of membranes and inhibits the enzyme nicotinamide adenine dinucleotide phosphate oxidase (NADPH-Oxidase). Zinc also induces the synthesis of metallothioneins, which are proteins effective in reducing hydroxyl radicals and sequestering reactive oxygen species (ROS) produced in stressful situations, such as in type 2 diabetes, obesity and cancer. Literature provides strong evidence for the role of zinc in the protection against oxidative stress in several diseases.\u003C\u002Fjats:p>",{"EN":7137},"Zinc and Oxidative Stress: Current Mechanisms",{"VOID":7139},"28353636",{"VOID":7141},"10.3390\u002Fantiox6020024","2024-12-29T13:20:46.978+00:00",[156],"https:\u002F\u002Fwww.mdpi.com\u002F2076-3921\u002F6\u002F2\u002F24",[7146,7163,7180,7197,7214,7231],{"id":7147,"sortIndex":22,"researcher":21,"roles":7148,"affiliations":7149,"properties":7158,"displayName":7160,"givenName":21,"familyName":21},"e08efdc0-1dab-48bf-a75b-09b187f2a152",[],[7150],{"id":7151,"sortIndex":22,"affiliation":7152,"properties":21},"f0f1838b-638a-4df5-82bf-3591dca685e5",{"id":7151,"createTime":21,"updateTime":21,"relativeEntities":7153,"slug":21,"properties":7154,"entityType":21,"verifyStatus":21,"verifyTime":21,"verifyNote":21,"languages":21,"translateLanguages":21,"viewCount":21,"url":21,"parentIds":7157,"statistic":21},[],{"title":7155},{"EN":7156},"Department of Nutrition, Federal University of Piauí, Campus Minister Petrônio Portela, Teresina 64049-550, Brazil",[],{"title":7159,"openalex":7161},{"EN":7160},"Dilina N. 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