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Immunohistochemical localization of annexins I, II (p36 and p11 subunits), IV, and VI in the human hippocampus, Am J Pathol, 145, 640\n10.1074\u002Fjbc.M111.244038\n10.1248\u002Fbpb.28.1342\n10.1385\u002FJMN:30:3:249\n10.1007\u002Fs00401-007-0247-0\n10.1016\u002Fj.neuroscience.2009.11.074\n10.1179\u002F1743132814Y.0000000434\n10.3389\u002Ffnagi.2014.00093\n10.1179\u002F174313208X355495\n10.1097\u002FANA.0b013e31822aa1f2\n10.3389\u002Ffnagi.2013.00015\n10.1006\u002Fexnr.1998.6892\n10.1016\u002Fj.neuroimage.2011.07.056\nMattsson N, 2010, Converging pathways of chromogranin and amyloid metabolism in the brain, J Alzheimers Dis, 20, 1039, 10.3233\u002FJAD-2010-091651",{"EN":159},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Introduction\u003C\u002Fjats:title>\u003Cjats:p>We performed a comprehensive quantitative proteomics study on human hippocampus tissue involving all Braak stages to assess changes in protein abundance over the various stages of Alzheimer's disease (AD).\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>Hippocampal subareas CA1 and subiculum of 40 cases were isolated using laser capture microdissection and analyzed using mass spectrometry. Immunoblotting and immunohistochemistry were used for validation.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Over the Braak stages, an altered expression was found for 372 proteins including changes in levels of extracellular matrix components, and in calcium‐dependent signaling proteins. Early changes were observed in levels of proteins related to cytoskeletal dynamics and synaptic components including an increase in RIMS1 and GRIK4. Several synaptic proteins, such as BSN, LIN7A, DLG2, ‐3, and ‐4, exhibit an early‐up, late‐down expression pattern.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Discussion\u003C\u002Fjats:title>\u003Cjats:p>This study provides new insight into AD‐dependent changes in protein levels in the hippocampus during AD pathology, identifying potential novel therapeutic targets and biomarkers.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":161},"Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's disease",{"VOID":163},"10.1016\u002Fj.jalz.2015.11.002","PUBLICATION","VERIFIED","Auto Verify","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS1552526015029878",[169,186,202,214,234,247,259,272,285],{"id":170,"sortIndex":171,"researcher":18,"roles":172,"affiliations":174,"properties":183},"89f2a950-68e7-4211-bce6-fd98d3d36123",4,[173],"AUTHOR",[175],{"id":18,"sortIndex":19,"affiliation":176,"properties":18},{"id":177,"createTime":178,"updateTime":178,"relativeEntities":179,"slug":18,"properties":180,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"93996d8b-8e86-4bca-bd09-7e981d4583cb","2024-02-07T12:35:53.272+00:00",[],{"title":181},{"VI":182},"Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, Amsterdam, The Netherlands",{"title":184},{"VI":185},"Roel C. van der Schors",{"id":187,"sortIndex":188,"researcher":18,"roles":189,"affiliations":190,"properties":199},"c63487a4-9575-43c8-b852-58667e1e0193",3,[173],[191],{"id":18,"sortIndex":19,"affiliation":192,"properties":18},{"id":193,"createTime":194,"updateTime":194,"relativeEntities":195,"slug":18,"properties":196,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"b93d90ec-0d61-402d-8ffc-cc254663daf9","2024-02-07T12:35:53.255+00:00",[],{"title":197},{"VI":198},"Department of Pathology, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands",{"title":200},{"VI":201},"Jeroen J.M. Hoozemans",{"id":203,"sortIndex":98,"researcher":18,"roles":204,"affiliations":205,"properties":211},"d3a98448-779c-4659-8da1-bf36727261ee",[173],[206],{"id":18,"sortIndex":19,"affiliation":207,"properties":18},{"id":193,"createTime":194,"updateTime":194,"relativeEntities":208,"slug":18,"properties":209,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":210},{"VI":198},{"title":212},{"VI":213},"Saskia M. van der Vies",{"id":215,"sortIndex":19,"researcher":18,"roles":216,"affiliations":217,"properties":231},"768b9b1e-ade6-4faf-a2e2-f721ba5e20e8",[173],[218,226],{"id":219,"sortIndex":220,"affiliation":221,"properties":225},"1c9edb1c-c564-4620-9c10-2b2a4d0d20c8",1,{"id":177,"createTime":178,"updateTime":178,"relativeEntities":222,"slug":18,"properties":223,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":224},{"VI":182},{},{"id":18,"sortIndex":19,"affiliation":227,"properties":18},{"id":193,"createTime":194,"updateTime":194,"relativeEntities":228,"slug":18,"properties":229,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":230},{"VI":198},{"title":232},{"VI":233},"David C. Hondius",{"id":235,"sortIndex":236,"researcher":18,"roles":237,"affiliations":238,"properties":244},"90396d31-b3d2-4a0f-976f-c2539ffe7310",7,[173],[239],{"id":18,"sortIndex":19,"affiliation":240,"properties":18},{"id":193,"createTime":194,"updateTime":194,"relativeEntities":241,"slug":18,"properties":242,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":243},{"VI":198},{"title":245},{"VI":246},"Annemieke J.M. Rozemuller",{"id":248,"sortIndex":88,"researcher":18,"roles":249,"affiliations":250,"properties":256},"d7a2aeb4-6dcc-499f-b0c7-46ca75ebb3cc",[173],[251],{"id":18,"sortIndex":19,"affiliation":252,"properties":18},{"id":177,"createTime":178,"updateTime":178,"relativeEntities":253,"slug":18,"properties":254,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":255},{"VI":182},{"title":257},{"VI":258},"August B. Smit",{"id":260,"sortIndex":261,"researcher":18,"roles":262,"affiliations":263,"properties":269},"1f999e8c-6dc3-4e97-9358-b398e234714d",5,[173],[264],{"id":18,"sortIndex":19,"affiliation":265,"properties":18},{"id":193,"createTime":194,"updateTime":194,"relativeEntities":266,"slug":18,"properties":267,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":268},{"VI":198},{"title":270},{"VI":271},"Elise S. van 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L., 1988, Clinical Dementia Rating (CDR), Psychopharmacol Bull, 24, 637\n10.2174\u002F156720512801322591\n10.1017\u002FS1041610297004870\nWilliams M.M., 2013, Progression of Alzheimer's disease as measured by Clinical Dementia Rating Sum of Boxes scores, Alzheimers Dement, 9, S39, 10.1016\u002Fj.jalz.2012.01.005\nO'Bryant S.E., 2010, Validation of the new interpretive guidelines for the Clinical Dementia Rating Scale Sum of Boxes Score in the National Alzheimer's Coordinating Center Database, Arch Neurol, 67, 746\n10.1097\u002FWAD.0b013e318191c7dd\nWechsler D., 1973, Manual: Wechsler Memory Scale\n10.1076\u002Fclin.14.4.526.7204\nWechsler D., 1955, Manual: Wechsler Adult Intelligence Scale\n10.1037\u002Fh0093567\nLamberty G.J., 1994, Derived Trail Making Test Indexes—a preliminary report, Cogn Behav Neurol, 7, 230\nStrauss E., 2006, A compendium of neuropsychological tests: Administration, norms, and commentary, third edition\n10.1017\u002FS1355617708080521\n10.1017\u002FS1355617707070531\n10.1111\u002Fj.1365-2796.2004.01388.x\n10.1002\u002Fana.23650\n10.1001\u002Farchgenpsychiatry.2011.155\n10.1002\u002Fana.410300410\n10.1212\u002FWNL.53.9.1942\n10.1002\u002Fana.410320311\n10.1016\u002Fj.neuropsychologia.2009.03.004\n10.1080\u002F13854040801894730\nDuff K., 2008, Short‐term practice effects in amnestic mild cognitive impairment: implications for diagnosis and treatment, Int Psychogeriatr, 20, 986, 10.1017\u002FS1041610208007254\nCooper D.B., 2004, Category fluency in mild cognitive impairment—reduced effect of practice in test‐retest conditions, Alzheimers Dis Assoc Dis, 18, 120, 10.1097\u002F01.wad.0000127442.15689.92",{"EN":339},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Introduction\u003C\u002Fjats:title>\u003Cjats:p>The Uniform Data Set (UDS) neuropsychological battery is frequently used in clinical studies. However, practice effects, effectiveness as a measure of global cognitive functioning, and detection of mild cognitive impairment have not been examined.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>A normative total score for the UDS has been developed. Linear discriminant analysis determined classification accuracy in identifying cognitively normal and impaired groups. Practice effects were examined in cognitively normal and cognitively impaired groups.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>The total score differentiates between cognitively normal participants and those with dementia, but does not accurately identify individuals with mild cognitive impairment (MCI). Mean total scores for test‐exposed participants were significantly higher than test‐naive participants in both the normal and MCI groups and were higher, but not significantly so, in the dementia group.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusion\u003C\u002Fjats:title>\u003Cjats:p>The total score's classification accuracy discriminates between cognitively normal versus participants who have dementia. The total score appears subject to practice effects.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":341},"Diagnostic accuracy and practice effects in the National Alzheimer's Coordinating Center Uniform Data Set neuropsychological 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Caban-Holt",{"id":374,"sortIndex":188,"researcher":18,"roles":375,"affiliations":376,"properties":396},"c8be3dad-d2ca-4b22-baba-e35d05477596",[173],[377,391],{"id":378,"sortIndex":220,"affiliation":379,"properties":388},"deba5433-4ca9-4315-aa86-73f256159f57",{"id":380,"createTime":381,"updateTime":382,"relativeEntities":383,"slug":384,"properties":385,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"5cd294bb-e6ef-46c7-99e2-72cf3da31808","2024-10-07T10:12:15.081+00:00","2024-10-12T17:37:10.517+00:00",[],"Department-of-Neurology-University-of-Kentucky-Lexington-KY-United-States",{"title":386},{"EN":387},"Department of Neurology, University of Kentucky, Lexington, KY, United States",{"title":389},{"VI":390},"Department of Neurology, University of Kentucky, Lexington, KY, 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DH, 2004, Brain 18F‐FDG PET in the diagnosis of neurodegenerative dementias: comparison with perfusion SPECT and with clinical evaluations lacking nuclear imaging, J Nucl Med, 45, 594\n10.1038\u002Fjcbfm.2009.188\n10.2967\u002Fjnumed.114.152405\n10.1177\u002F0271678X16645593\n10.1097\u002F00004647-200106000-00002\n10.1097\u002F00004647-199609000-00008\n10.1006\u002Fnimg.1996.0066\n10.1016\u002Fj.neuroimage.2007.03.004\nKoeppe RA, 2005, 11C‐DTBZ and 18F‐FDG PET measures in differentiating dementias, J Nucl Med, 46, 936\n10.2967\u002Fjnumed.115.168732\n10.2967\u002Fjnumed.110.082057\n10.1371\u002Fjournal.pone.0139926\n10.1186\u002Fs40478-015-0220-4\n10.2967\u002Fjnumed.115.158519\nGaribotto V, 2016, Erratum to: dual‐phase amyloid PET: hitting two birds with one stone, Eur J Nucl Med Mol Imaging, 43, 1747, 10.1007\u002Fs00259-016-3426-1\n10.1007\u002Fs00259-016-3393-6\n10.1007\u002Fs00259-016-3363-z\n10.1186\u002Fs13195-016-0204-z\nKChiotis LSaint‐Aubert ERodriguez‐Vieitez ALeuzy OAlmkvist ISavitcheva et al.Longitudinal changes of tau PET imaging in relation to hypometabolism in prodromal and Alzheimer's disease dementia. Mol Psychiatry2017 May 16https:\u002F\u002Fdoi.org\u002F10.1038\u002Fmp.2017.108. [Epub ahead of print]\n10.1016\u002Fj.jalz.2011.03.005\n10.1001\u002Farchneur.56.3.303\n10.1016\u002FS1474-4422(14)70090-0\n10.1002\u002Fhbm.10123\n10.1212\u002FWNL.0b013e31827f0fd1\n10.1093\u002Fbrain\u002F113.1.27\n10.1038\u002Fjcbfm.1988.133\nChiu NT, 2004, Educational level influences regional cerebral blood flow in patients with Alzheimer's disease, J Nucl Med, 45, 1860\n10.3233\u002FJAD-121897\nSmailagic N, 2015, (1)(8)F‐FDG PET for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI), Cochrane Database Syst Rev, 1, CD010632\nKogure D, 2000, Longitudinal evaluation of early Alzheimer's disease using brain perfusion SPECT, J Nucl Med, 41, 1155\n10.1093\u002Fbrain\u002Fawp132\n10.1016\u002Fj.jalz.2014.05.855\n10.1016\u002Fj.nbd.2014.08.016\n10.1038\u002Fmp.2016.37\n10.1007\u002Fs00401-016-1560-2\n10.1002\u002Fana.22248\nMajerova P, 2014, Microglia display modest phagocytic capacity for extracellular tau oligomers, J Neuroinflammation, 11, 161, 10.1186\u002Fs12974-014-0161-z\n10.2967\u002Fjnumed.110.087031\n10.1038\u002Fnn.4492\n10.1007\u002Fs00259-014-2919-z\n10.1007\u002FBF00308809\n10.1371\u002Fjournal.pone.0140311\n10.1016\u002FS1474-4422(12)70291-0\n10.1212\u002FWNL.0b013e3182840bbe\n10.1177\u002F0271678X16641128",{"EN":569},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Introduction\u003C\u002Fjats:title>\u003Cjats:p>Cross‐sectional findings using the tau tracer [\u003Cjats:sup>18\u003C\u002Fjats:sup>F]THK5317 (THK5317) have shown that [\u003Cjats:sup>18\u003C\u002Fjats:sup>F]fluorodeoxyglucose (FDG) positron emission tomography (PET) data can be approximated using perfusion measures (early‐frame standardized uptake value ratio; ratio of tracer delivery in target to reference regions). In this way, a single PET study can provide both functional and molecular information.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>We included 16 patients with Alzheimer's disease who completed follow‐up THK5317 and FDG studies 17 months after baseline investigations. Linear mixed‐effects models and annual percentage change maps were used to examine longitudinal change.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Limited spatial overlap was observed between areas showing declines in THK5317 perfusion measures and FDG. Minimal overlap was seen between areas showing functional change and those showing increased retention of THK5317.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Discussion\u003C\u002Fjats:title>\u003Cjats:p>Our findings suggest a spatiotemporal offset between functional changes and tau pathology and a partial uncoupling between perfusion and metabolism, possibly as a function of Alzheimer's disease severity.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":571},"Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's disease",{"VOID":573},"10.1016\u002Fj.jalz.2017.11.008","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS155252601733844X",[576,604,616,628,659,671,700,715,739,751,770],{"id":577,"sortIndex":578,"researcher":18,"roles":579,"affiliations":580,"properties":601},"5db20ba3-63f1-47cf-9688-de9aed76b2ea",10,[173],[581,593],{"id":582,"sortIndex":220,"affiliation":583,"properties":592},"d69ebd38-3942-4581-ae39-ba99120f3cc4",{"id":584,"createTime":585,"updateTime":586,"relativeEntities":587,"slug":588,"properties":589,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"6dfe3877-c567-4656-9b9d-14e091718637","2023-12-14T18:23:20.940+00:00","2024-12-05T10:06:36.926+00:00",[],"Department-of-Geriatric-Medicine-Karolinska-University-Hospital-Huddinge-Sweden",{"title":590},{"VI":591},"Department of Geriatric Medicine, Karolinska University Hospital, Huddinge, Sweden",{},{"id":18,"sortIndex":19,"affiliation":594,"properties":18},{"id":595,"createTime":596,"updateTime":596,"relativeEntities":597,"slug":18,"properties":598,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"6dbfcc12-b744-4a1a-834e-ec857569aa56","2024-02-09T13:10:13.676+00:00",[],{"title":599},{"VI":600},"Division of Translational Alzheimer Neurobiology, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden",{"title":602},{"VI":603},"Agneta 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of Medical Physics, Uppsala University Hospital, Uppsala, Sweden",{},{"title":737},{"VI":738},"My Jonasson",{"id":740,"sortIndex":274,"researcher":18,"roles":741,"affiliations":742,"properties":748},"12b14501-b81f-4612-af12-1b3dc3c020fa",[173],[743],{"id":18,"sortIndex":19,"affiliation":744,"properties":18},{"id":595,"createTime":596,"updateTime":596,"relativeEntities":745,"slug":18,"properties":746,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":747},{"VI":600},{"title":749},{"VI":750},"Laure 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Census Bureau.Population projections (middle series). United States2002 Available at:www.census.gov.\n10.1001\u002Fjama.1989.03430180093036\n10.1212\u002FWNL.58.2.209\n10.1016\u002FS0197-4580(01)00231-7\n10.1001\u002Farchneur.59.10.1589\n10.1212\u002F01.wnl.0000176053.98907.3f\nBerlau D., 2007, Incidence of dementia continues to increase after age 90: results from the 90+ Study, Neurology, 68\n10.1001\u002Fjama.279.9.688\n10.1001\u002Fjama.288.17.2123\n10.1001\u002Farchneur.58.3.498\n10.1097\u002F01.wad.0000126614.87955.79\n10.1097\u002F01.gme.0000172880.40831.3b\nKawas C., 2003, Low weight in early adulthood and later life exercise increase chances of surviving to age 90, Neurology, 60\n10.1080\u002F13825580490511125\n10.1001\u002Farchinte.166.10.1115\nCorrada M., 2005, Braak and Braak staging and dementia in the oldest‐old: Preliminary results from the 90+ Study, Neurology, 64\n10.1212\u002FWNL.56.12.1690\n10.1001\u002Farchneur.57.5.713\n10.1002\u002Fana.410230206\n10.1212\u002FWNL.38.11.1682\n10.1097\u002F00006842-200205000-00014\nBerlau D.J., 2007, Dissociation of neuropathologic findings and cognition: case report of an apolipoprotein E epsilon 2\u002Fepsilon 2 genotype, Arch Neurol, 64, 1193, 10.1001\u002Farchneur.64.8.1193\nHead E., 2006, Higher levels of synaptophysin, but not GAP‐43 protein are associated with intact cognitive function in the oldest‐old: the 90+ Study, Neurology, 66\n10.1093\u002Faje\u002Fkwj114\n10.1093\u002Fageing\u002Fafl184\n10.1016\u002Fj.ypmed.2006.12.011\nCorrada M., 2004, Intake of antioxidant vitamins, calcium, beverages and mortality: the 90+ Study, Neurology, 62",{"EN":823},"\u003Cjats:p>Memories are the gifts from friends and family that stay with us forever, unless a person develops Alzheimer's disease. Leon J. Thal left many, many memories, along with his desire to create a world where people did not lose them to the ravages of dementing illnesses. Working from the bench to the clinic, he was an incomparable leader, scientist, and educator to whom many, including myself, owe much. The present description of a clinical, genetic, and pathologic study of the oldest old contains much of Leon's influence. With data from >950 subjects, a brain repository, and our collection of DNA, the investigators of the 90+ Study are receptive to collaborations. Through our collective efforts, we will continue the scientific work that Leon so strongly supported.\u003C\u002Fjats:p>",{"EN":825},"The oldest old and the 90+ Study",{"VOID":827},"10.1016\u002Fj.jalz.2007.11.007","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS1552526007006462",[830],{"id":831,"sortIndex":19,"researcher":18,"roles":832,"affiliations":833,"properties":842},"8f2e2af8-73d9-461b-a4c6-84f791948950",[173],[834],{"id":18,"sortIndex":19,"affiliation":835,"properties":18},{"id":836,"createTime":837,"updateTime":837,"relativeEntities":838,"slug":18,"properties":839,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"ccfec8e4-d68c-4920-ae1c-3fb7546f7a47","2023-12-12T20:28:45.491+00:00",[],{"title":840},{"VI":841},"Department of Neurology, Department of Neurobiology and Behavior, and Institute for Brain Aging and Dementia, University of California at Irvine, Irvine, CA, USA",{"title":843},{"VI":844},"Claudia H. Kawas",{"url":828,"publisher":846,"properties":868},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":847,"slug":10,"properties":848,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":851,"manageAffiliations":852,"indexDatabases":853,"url":18,"thumbnailPath":18,"statistic":18,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"issn":849,"title":850},{"VOID":13},{"EN":15},[],[],[854,861],{"id":102,"indexDatabase":855,"url":115,"indexYears":116,"academicFieldIds":860,"indexDatabaseRanking":125},{"id":104,"createTime":105,"updateTime":106,"relativeEntities":856,"label":857,"description":858,"key":112,"publicationTags":859,"standard":18},[],{"EN":109,"VI":109},{"EN":109,"VI":111},[114],[118,119,120,121,122,123,124],{"id":127,"indexDatabase":862,"url":142,"indexYears":18,"academicFieldIds":867,"indexDatabaseRanking":18},{"id":129,"createTime":130,"updateTime":131,"relativeEntities":863,"label":864,"description":865,"key":138,"publicationTags":866,"standard":18},[],{"EN":134,"VI":134},{"VI":136,"EN":137},[140,141],[144],{"volume":869,"pages":871},{"VOID":870},"4",{"VOID":872},"S56-S59","2008-01-01",2008,{"id":876,"createTime":877,"updateTime":878,"relativeEntities":879,"slug":880,"properties":881,"entityType":164,"verifyStatus":165,"verifyTime":878,"verifyNote":166,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":890,"fullTextUrl":18,"authors":891,"publicationType":297,"publisherRelationship":1018,"citationCount":18,"citationInfo":18,"publishDate":1046,"publishYear":1047,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":328},"bf9e9b96-46a7-4ec9-adfd-2cf183f1a800","2024-02-07T21:33:06.407+00:00","2025-02-14T23:51:43.903+00:00",[],"Association-of-GWAS-linked-loci-with-late-onset-Alzheimer-s-disease-in-a-northern-Han-Chinese-population",{"references":882,"abstract":884,"title":886,"doi":888},{"VOID":883},"10.1001\u002Farchneur.60.8.1119\n10.1016\u002Fj.jalz.2011.02.004\n10.1001\u002Farchneur.65.3.329\n10.1001\u002Farchpsyc.63.2.168\n10.3233\u002FJAD-2002-4307\n10.1038\u002Fng.440\n10.1038\u002Fng.439\n10.1001\u002Fjama.2010.574\n10.1038\u002Fng.803\n10.1038\u002Fng.801\n10.1001\u002Farchneurol.2010.147\n10.1001\u002Farchneurol.2010.201\n10.1001\u002Farchgenpsychiatry.2010.196\n10.1001\u002Farchneurol.2010.292\n10.1038\u002Fng.305\n10.1016\u002Fj.neuron.2007.05.022\n10.1016\u002Fj.neurobiolaging.2010.11.022\n10.1001\u002Farchneurol.2010.108\n10.1016\u002Fj.cca.2010.06.013\n10.1016\u002Fj.brainres.2010.06.018\n10.1016\u002Fj.jns.2010.09.027\n10.1212\u002FWNL.34.7.939\n10.1038\u002F75452\n10.1016\u002Fj.hepres.2005.12.007\nTerwilliger J, 1994, Handbook of human genetic linkage\n10.1080\u002F01621459.1995.10476572\n10.1002\u002Fgepi.20217\n10.1093\u002Fbioinformatics\u002F19.1.149\n10.1038\u002Fnrg2344\n10.1007\u002Fs002510100339\n10.1371\u002Fjournal.pone.0009369\n10.1038\u002Fnri2056\n10.1016\u002Fj.ajhg.2008.10.008\n10.1128\u002FMCB.00383-07\n10.2174\u002F156720511795256080\n10.1126\u002Fscience.1072545\n10.1186\u002F1750-1326-6-54\n10.1086\u002F512133\nAllen M, 2012, Association and heterogeneity at the GAPDH locus in Alzheimer's disease, Neurobiol Aging., 33, 203, 10.1016\u002Fj.neurobiolaging.2010.08.002\n10.1001\u002Fjama.1997.03550160069041\n10.1001\u002Fjama.299.11.1335\n10.1097\u002FEDE.0b013e318181b865\n10.1001\u002Farchneurol.2008.552",{"EN":885},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Objective\u003C\u002Fjats:title>\u003Cjats:p>Five genomewide association studies (GWAS) in white populations have recently identified and confirmed 9 novel Alzheimer's disease (AD) susceptibility loci (\u003Cjats:italic>CLU\u003C\u002Fjats:italic>, \u003Cjats:italic>CR1\u003C\u002Fjats:italic>, \u003Cjats:italic>PICALM, BIN1\u003C\u002Fjats:italic>, \u003Cjats:italic>ABCA7\u003C\u002Fjats:italic>, \u003Cjats:italic>MS4A\u003C\u002Fjats:italic> gene cluster, \u003Cjats:italic>CD2AP\u003C\u002Fjats:italic>, \u003Cjats:italic>CD33,\u003C\u002Fjats:italic> and \u003Cjats:italic>EPHA1\u003C\u002Fjats:italic>). These studies have been conducted almost exclusively in white populations and it is unclear whether these observations generalize to populations with different ethnicities.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>We recruited 1224 unrelated northern Han Chinese subjects comprising 612 patients with a clinical diagnosis of late‐onset AD (LOAD) according to the criteria of the National Institute of Neurological and Communicative Diseases and Stroke\u002FAlzheimer's Disease and Related Disorders Association and 612 healthy age‐ and sex‐matched control subjects. Because of our previous study investigating \u003Cjats:italic>CLU, CR1,\u003C\u002Fjats:italic> and \u003Cjats:italic>PICALM\u003C\u002Fjats:italic> in the Han population, we limited the current analysis to \u003Cjats:italic>BIN1\u003C\u002Fjats:italic>, \u003Cjats:italic>ABCA7\u003C\u002Fjats:italic>, \u003Cjats:italic>MS4A\u003C\u002Fjats:italic> gene cluster, \u003Cjats:italic>CD2AP\u003C\u002Fjats:italic>, \u003Cjats:italic>CD33\u003C\u002Fjats:italic>, and \u003Cjats:italic>EPHA1\u003C\u002Fjats:italic>.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>In a multivariate analysis, associations of \u003Cjats:italic>MS4A6A\u003C\u002Fjats:italic> (rs610932; odds ratio = 0.632, Bonferroni corrected \u003Cjats:italic>P\u003C\u002Fjats:italic> = .019) and \u003Cjats:italic>CD33\u003C\u002Fjats:italic> (rs3865444; odds ratio = 1.492, Bonferroni corrected \u003Cjats:italic>P\u003C\u002Fjats:italic> = .017) with LOAD were replicated successfully. When these data were stratified by apolipoprotein E (\u003Cjats:italic>APOE\u003C\u002Fjats:italic>) ε4 status, both rs610932 and rs610932 were evident only among subjects without the \u003Cjats:italic>APOE\u003C\u002Fjats:italic> ε4 allele. For \u003Cjats:italic>BIN1\u003C\u002Fjats:italic>, assuming a dominant model of inheritance, a positive association for rs7561528 in \u003Cjats:italic>APOE\u003C\u002Fjats:italic> ε4 carriers was observed. This association, however, did not remain significant after Bonferroni correction. As for \u003Cjats:italic>ABCA7\u003C\u002Fjats:italic>, \u003Cjats:italic>CD2AP,\u003C\u002Fjats:italic> and \u003Cjats:italic>EPHA1\u003C\u002Fjats:italic> single nucleotide polymorphisms from recent GWAS, despite the similar directional effects, no significant differences in genotype and estimated allele frequency distribution between patients and control subjects were observed.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusions\u003C\u002Fjats:title>\u003Cjats:p>This study provides the first independent evidence that \u003Cjats:italic>MS4A\u003C\u002Fjats:italic> and \u003Cjats:italic>CD33\u003C\u002Fjats:italic> loci are associated with the risk of LOAD in northern Han Chinese population. Genotypes at the two loci confer risk predominantly in \u003Cjats:italic>APOE\u003C\u002Fjats:italic> ε4‐negative subjects.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":887},"Association of GWAS‐linked loci with late‐onset Alzheimer's disease in a northern Han Chinese 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athttp:\u002F\u002Fwww.worldpharmanews.com\u002Fdevelopment\u002F3931‐alzheimer‐s‐experts‐call‐for‐changes‐in‐fda‐drug‐approval‐standards Accessed November 26 2019.",{},{"id":1500,"createTime":1501,"updateTime":1502,"relativeEntities":1503,"slug":1504,"properties":1505,"entityType":164,"verifyStatus":165,"verifyTime":1502,"verifyNote":166,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1514,"fullTextUrl":18,"authors":1515,"publicationType":297,"publisherRelationship":1599,"citationCount":18,"citationInfo":18,"publishDate":1627,"publishYear":1628,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":328},"108d45ff-e01b-473a-b367-782965b0da5d","2024-01-16T22:52:59.616+00:00","2025-02-23T23:46:53.450+00:00",[],"Declining-incidence-of-dementia-A-national-registry-based-study-over-20-years",{"references":1506,"abstract":1508,"title":1510,"doi":1512},{"VOID":1507},"Prince M, 2015, World Alzheimer Report 2015 The Global Impact of Dementia, Alzheimers Dis Int, 1\n10.1016\u002FS0140-6736(17)31363-6\n10.1016\u002FS0140-6736(15)60461-5\n10.1161\u002FCIRCRESAHA.116.309115\n10.1056\u002FNEJMoa1504327\n10.1212\u002FWNL.0b013e3182553be6\nGrasset L, 2017, Trends in dementia incidence: Evolution over a 10‐year period in France, Alzheimers Dement, 12, 272, 10.1016\u002Fj.jalz.2015.11.001\nMatthews FE, 2016, A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II, Nat Commun, 7, 10.1038\u002Fncomms11398\n10.1016\u002Fj.jalz.2015.06.1894\n10.1001\u002Fjamaneurol.2017.1964\nAhmadi‐Abhari S, 2017, Temporal trend in dementia incidence since 2002 and projections for prevalence in England and Wales to 2040: Modelling study, BMJ, 358, 1\n10.2147\u002FCLEP.S91125\n10.1177\u002F1403494810387965\n10.1177\u002F1403494810395825\nPottegård A, 2017, Data Resource Profile: The Danish National Prescription Registry, Int J Epidemiol, 46\n10.1159\u002F000345485\nRajan KB, 2018, Prevalence and incidence of clinically diagnosed Alzheimer's disease dementia from 1994 to 2012 in a population study, Alzheimers Dement, 15, 1, 10.1016\u002Fj.jalz.2018.07.216\n10.1212\u002FWNL.0000000000003932\n10.2147\u002FCLEP.S163649\nDoblhammer G, 2015, Compression or expansion of dementia in Germany? An observational study of shortterm trends in incidence and death rates of dementia between 2006\u002F07 and 2009\u002F10 based on German health insurance data, Alzheimers Res Ther, 7, 1, 10.1186\u002Fs13195-015-0146-x\n10.1017\u002FS1041610216000818\n10.1016\u002Fj.jalz.2017.02.010\nBussel EF, 2017, Dementia incidence trend over 1992–2014 in the Netherlands: Analysis of primary care data, PLoS Med, 14, 1\n10.2147\u002FCLEP.S178955\n10.1016\u002Fj.jalz.2009.01.026\n10.1111\u002Fj.1600-0447.2007.01006.x\n10.1017\u002FS0033291713000299\n10.3233\u002FJAD-150708\n10.1212\u002FWNL.0b013e318292a2f9\n10.1016\u002FS0140-6736(13)61570-6\n10.1001\u002Fjamainternmed.2016.6807\n10.1111\u002Fjgs.14575\nPedersen CB, 2006, The Danish Civil Registration System. A cohort of eight million persons, Dan Med Bull, 53, 441\nJørgensen K, 2014, Prævalens af demens i Danmark, Ugeskr Læger, 177, 1041\n10.1159\u002F000107084",{"EN":1509},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Introduction\u003C\u002Fjats:title>\u003Cjats:p>The aim of this study was to investigate the registry‐based national time trends in incidence and prevalence rates of dementia from 1996 to 2015.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>We assessed annual incidence and prevalence using longitudinal data from nationwide registries on dementia status and demographics on all residents ≥ 65 years old in Denmark.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Our population comprised 2 million people, of whom 152,761 were diagnosed with dementia. The age‐ and sex‐adjusted incidence rate increased, on average, by 9% annually from 1996 to 2003, followed by a 2% annual decline, while total prevalence increased during the whole period.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Discussion\u003C\u002Fjats:title>\u003Cjats:p>This is the first study to report continuous time trends of incidence and prevalence in an entire national population. The incidence rate has declined steadily since 2003, while the total prevalence is still increasing. Future health care planning on prevention and treatment of dementia should take these findings into account.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":1511},"Declining incidence of dementia: A national registry‐based study over 20 years",{"VOID":1513},"10.1016\u002Fj.jalz.2019.07.006","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS1552526019351271",[1516,1531,1548,1563,1575,1587],{"id":1517,"sortIndex":171,"researcher":18,"roles":1518,"affiliations":1519,"properties":1528},"efd7f6ed-c3d9-45bf-b140-1f0c3216d675",[173],[1520],{"id":18,"sortIndex":19,"affiliation":1521,"properties":18},{"id":1522,"createTime":1523,"updateTime":1523,"relativeEntities":1524,"slug":18,"properties":1525,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"99572ab5-3863-40f9-9558-1dfb88ee8b7e","2024-01-16T22:52:59.690+00:00",[],{"title":1526},{"VI":1527},"National Centre for 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MJ, 1993, The radiologic prediction of Alzheimer disease: the atrophic hippocampal formation, AJNR Am J Neuroradiol, 14, 897\n10.1016\u002FS0140-6736(06)69113-7\n10.1016\u002FS0197-4580(97)00056-0\n10.1073\u002Fpnas.191044198\n10.1097\u002F00005072-199812000-00009\n10.1212\u002FWNL.46.3.707\n10.1002\u002F1531-8249(199903)45:3\u003C358::AID-ANA12>3.0.CO;2-X\n10.1016\u002FS1474-4422(07)70178-3\n10.1212\u002FWNL.0b013e3181cb3e25\nTorpy JM, 2009, JAMA patient page. Mild cognitive impairment, JAMA, 302, 452, 10.1001\u002Fjama.302.4.452\n10.1016\u002Fj.bbadis.2008.07.008\n10.1212\u002F01.wnl.0000279336.36610.f7\n10.1212\u002FWNL.0b013e318245f447\n10.1097\u002FNEN.0b013e31824b211b\n10.1056\u002FNEJMoa1304839\n10.1016\u002Fj.expneurol.2009.09.024\n10.1038\u002Fnrd3115\n10.1038\u002Fnrneurol.2010.4\n10.1016\u002FS0197-4580(01)00230-5\n10.2967\u002Fjnumed.107.040675\n10.1101\u002Fcshperspect.a006213\n10.1016\u002Fj.jalz.2012.05.2116\n10.1016\u002Fj.jalz.2011.03.005\n10.1016\u002FS1474-4422(03)00530-1\n10.1101\u002Fcshperspect.a006221\n10.1212\u002F01.WNL.0000046581.81650.D0\n10.1001\u002Farchneurol.2008.596\n10.1212\u002FWNL.0b013e3182563bd0\n10.1002\u002Fana.20730\n10.1002\u002Femmm.200900048\n10.1016\u002Fj.neurobiolaging.2007.03.029\n10.1212\u002FWNL.0b013e3181bc010c\n10.2967\u002Fjnumed.109.064360\n10.1016\u002FS0304-3940(01)02285-6\n10.1002\u002Fana.10661\n10.1093\u002Fbrain\u002Fawl269\n10.1159\u002F000216841\n10.1002\u002Fgps.2353\n10.1002\u002Fgps.2195\n10.1016\u002Fj.neulet.2007.03.064\nMattsson N, 2012, Longitudinal cerebrospinal fluid biomarkers over four years in mild cognitive impairment, J Alzheimers Dis, 30, 767, 10.3233\u002FJAD-2012-120019\n10.3233\u002FJAD-2007-12307\n10.1016\u002FS0304-3940(99)00617-5\n10.1016\u002FS1474-4422(09)70299-6\n10.1016\u002FS1474-4422(12)70291-0\n10.1136\u002Fjnnp.2006.100529\n10.1159\u002F000068478\n10.1056\u002FNEJMoa1202753\n10.1159\u002F000335729\n10.1007\u002Fs00401-013-1139-0\n10.1001\u002Farchneur.60.12.1696\n10.1016\u002Fj.neurobiolaging.2005.07.003\n10.1001\u002Farchneur.64.3.noc60123\n10.1001\u002Farchneurol.2011.105\n10.1016\u002FS1474-4422(03)00530-1\n10.1002\u002Fana.21610\n10.1016\u002Fj.neurobiolaging.2007.08.010\n10.1080\u002F15622970701535502\n10.1016\u002FS1474-4422(06)70355-6\n10.1212\u002F01.wnl.0000267428.62582.aa\n10.1001\u002Fjama.2009.1064\n10.1001\u002Farchneurol.2009.55\n10.1016\u002FS1474-4422(13)70194-7\n10.1159\u002F000105017\n10.1016\u002FS0197-4580(98)00022-0\n10.1001\u002Farchneur.56.6.673\n10.1373\u002Fclinchem.2004.039347\n10.1373\u002Fclinchem.2006.081679\n10.1034\u002Fj.1600-0404.107.s179.9.x\n10.1016\u002Fj.neulet.2006.07.009\n10.1258\u002Facb.2009.008232\nTeunissen CE, 2010, Standardization of assay procedures for analysis of the CSF biomarkers amyloid beta(1‐42), tau, and phosphorylated tau in Alzheimer's disease: report of an International Workshop, Int J Alzheimers Dis, 2010\n10.1016\u002Fj.jalz.2011.05.2243\n10.2217\u002Fbmm.12.46\n10.1016\u002FS1474-4422(10)70223-4\n10.2217\u002Fbmm.09.83\n10.1007\u002Fs00702-009-0277-y\nTeipel SJ, 2013, Perspectives for multimodal neurochemical and imaging biomarkers in Alzheimer's disease, J Alzheimers Dis, 33, S329, 10.3233\u002FJAD-2012-129030\n10.1093\u002Fbrain\u002Fawq204\n10.1602\u002Fneurorx.1.2.213\n10.1016\u002FS0304-3940(00)01697-9\n10.1212\u002F01.wnl.0000242732.06714.0f\n10.1038\u002Fsj.mp.4001220\n10.1136\u002Fbmj.326.7379.41\n10.1097\u002FWAD.0b013e31821300bc\n10.1037\u002F0894-4105.22.4.469\n10.1016\u002Fj.expneurol.2009.07.024\n10.1038\u002Fmp.2008.84\n10.3122\u002Fjabfm.2012.03.100181\nDWilkinson ASganga CStave BO'Connell.Implications of the Facing Dementia Survey for health care professionals across Europe.Int J Clin Pract Suppl2005;27–31\n10.1093\u002Ffampra\u002Fcml068\n10.1159\u002F000311703\n10.2174\u002F156720509788486509\nAlzheimer's Disease Neuroimaging Initiative. Available at:http:\u002F\u002Fadni.loni.usc.edu last accessed 4 February 2014.\nEuropean Medicines Agency.Qualification opinion of Alzheimer's disease.Novel methodologies\u002Fbiomarkers for BMS‐708163.2011. Available at:http:\u002F\u002Fwww.ema.europa.eu\u002Fdocs\u002Fen_GB\u002Fdocument_library\u002FRegulatory_and_procedural_guideline\u002F2011\u002F02\u002FWC500102018.pdf last accessed 4 February 2014.\n10.1016\u002Fj.jalz.2011.03.003\n10.1212\u002FWNL.0b013e3181af79fb\n10.3174\u002Fajnr.A1809\n10.1016\u002Fj.neurobiolaging.2011.12.017\nBrys M, 2009, Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's disease, J Alzheimers Dis, 16, 351, 10.3233\u002FJAD-2009-0968\n10.1196\u002Fannals.1379.012\nLeon MJ, 2002, Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment, Neurosci Lett, 333, 183, 10.1016\u002FS0304-3940(02)01038-8\nQuinn JF, 2004, Suppression of longitudinal increase in CSF F2‐isoprostanes in Alzheimer's disease, J Alzheimers Dis, 6, 93, 10.3233\u002FJAD-2004-6110\n10.1002\u002Fana.23908\n10.1111\u002Fj.1532-5415.2007.01600.x\nMattsson N, 2010, To know or not to know: ethical issues related to early diagnosis of Alzheimer's disease, Int J Alzheimers Dis, 2010\n10.1212\u002F01.WNL.0000148604.77591.67\n10.1016\u002Fj.neurobiolaging.2009.12.026\n10.1016\u002FS1474-4422(09)70139-5\n10.1385\u002FMN:24:1-3:087",{"EN":1639},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:label \u002F>\u003Cjats:p>Several potential disease‐modifying drugs for Alzheimer's disease (AD) have failed to show any effect on disease progression in clinical trials, conceivably because the AD subjects are already too advanced to derive clinical benefit from treatment and because diagnosis based on clinical criteria alone introduces a high misdiagnosis rate. Thus, well‐validated biomarkers for early detection and accurate diagnosis are crucial. Low cerebrospinal fluid (CSF) concentrations of the amyloid‐β (Aβ\u003Cjats:sub>1‐42\u003C\u002Fjats:sub>) peptide, in combination with high total tau and phosphorylated tau, are sensitive and specific biomarkers highly predictive of progression to AD dementia in patients with mild cognitive impairment. However, interlaboratory variations in the results seen with currently available immunoassays are of concern. Recent worldwide standardization efforts and quality control programs include standard operating procedures for both preanalytical (e.g., lumbar puncture and sample handling) and analytical (e.g., preparation of calibration curve) procedures. Efforts are also ongoing to develop highly reproducible assays on fully automated instruments. These global standardization and harmonization measures will provide the basis for the generalized international application of CSF biomarkers for both clinical trials and routine clinical diagnosis of AD.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":1641},"Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease",{"VOID":1643},"10.1016\u002Fj.jalz.2014.02.004","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS1552526014000661",[1646,1661,1678,1693,1708,1739],{"id":1647,"sortIndex":220,"researcher":18,"roles":1648,"affiliations":1649,"properties":1658},"d138ad3b-0744-4fd4-9c97-bb13bdc9e66a",[173],[1650],{"id":18,"sortIndex":19,"affiliation":1651,"properties":18},{"id":1652,"createTime":1653,"updateTime":1653,"relativeEntities":1654,"slug":18,"properties":1655,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"63486b8f-f096-4cd6-81bf-b744140a6410","2023-12-18T04:09:02.086+00:00",[],{"title":1656},{"VI":1657},"Institute for Memory and Alzheimer's Disease, Institute of Neurology, Pitié-Salpêtrière Hospital Group, Pierre and Marie Curie University, Paris, France",{"title":1659},{"VI":1660},"Bruno Dubois",{"id":1662,"sortIndex":274,"researcher":18,"roles":1663,"affiliations":1664,"properties":1675},"6a7c4d61-b529-4208-96fb-687318a5ab81",[173],[1665],{"id":18,"sortIndex":19,"affiliation":1666,"properties":18},{"id":1667,"createTime":1668,"updateTime":1669,"relativeEntities":1670,"slug":1671,"properties":1672,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"4f6a5b84-e539-43d9-94a2-0806796b6b7b","2024-01-11T12:58:52.964+00:00","2024-10-16T10:41:44.893+00:00",[],"Department-of-Neurology-Washington-University-School-of-Medicine-St-Louis-Mo-USA",{"title":1673},{"VI":1674},"Department of Neurology, Washington University School of Medicine, St. Louis, Mo. USA",{"title":1676},{"VI":1677},"Anne M. Fagan",{"id":1679,"sortIndex":188,"researcher":18,"roles":1680,"affiliations":1681,"properties":1690},"150f921d-5fcb-4df0-b2f3-e90bc31065ad",[173],[1682],{"id":18,"sortIndex":19,"affiliation":1683,"properties":18},{"id":1684,"createTime":1685,"updateTime":1685,"relativeEntities":1686,"slug":18,"properties":1687,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"640f459b-c9f8-48aa-a5b6-15fed205e12d","2023-12-18T04:09:02.144+00:00",[],{"title":1688},{"VI":1689},"Universitätsklinikum Erlangen and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany",{"title":1691},{"VI":1692},"Piotr Lewczuk",{"id":1694,"sortIndex":19,"researcher":18,"roles":1695,"affiliations":1696,"properties":1705},"ed60f448-9cbd-47d2-ab06-efcfeeccaf3f",[173],[1697],{"id":18,"sortIndex":19,"affiliation":1698,"properties":18},{"id":1699,"createTime":1700,"updateTime":1700,"relativeEntities":1701,"slug":18,"properties":1702,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"44147c73-0ad4-4950-9007-4f58f385a198","2023-12-18T04:09:02.049+00:00",[],{"title":1703},{"VI":1704},"Department of Neuroscience and Physiology, Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, University of Gothenburg, Mölndal, Sweden",{"title":1706},{"VI":1707},"Kaj Blennow",{"id":1709,"sortIndex":171,"researcher":18,"roles":1710,"affiliations":1711,"properties":1736},"d4c60ff9-86b2-484f-b0c7-12fbb58c6d24",[173],[1712,1726],{"id":1713,"sortIndex":19,"affiliation":1714,"properties":1723},"a5c00e52-db1d-43c6-84cd-55aafef3eb6a",{"id":1715,"createTime":1716,"updateTime":1717,"relativeEntities":1718,"slug":1719,"properties":1720,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"41abc804-0fc7-4e6d-85cd-c2571beb0fe3","2023-12-27T02:48:59.208+00:00","2024-11-26T08:12:49.932+00:00",[],"Department-of-Psychiatry-New-York-University-School-of-Medicine-New-York-NY-USA",{"title":1721},{"VI":1722},"Department of Psychiatry, New York University School of Medicine,, New York, NY USA",{"title":1724},{"VI":1725},"Department of Psychiatry, New York University School of Medicine, New York, NY, USA",{"id":1727,"sortIndex":220,"affiliation":1728,"properties":1735},"5db648e7-ac9b-4de3-9430-2f9a450c111b",{"id":1729,"createTime":1730,"updateTime":1730,"relativeEntities":1731,"slug":18,"properties":1732,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"229ae4e6-6b3b-4e58-ba6d-ed6e03f19bba","2023-12-18T04:09:02.192+00:00",[],{"title":1733},{"VI":1734},"Centre for Brain Health, New York University School of Medicine, New York, NY, USA",{},{"title":1737},{"VI":1738},"Mony J. de Leon",{"id":1740,"sortIndex":261,"researcher":18,"roles":1741,"affiliations":1742,"properties":1748},"a8397c5e-4547-4f91-9981-b2a7e751152a",[173],[1743],{"id":18,"sortIndex":19,"affiliation":1744,"properties":18},{"id":1652,"createTime":1653,"updateTime":1653,"relativeEntities":1745,"slug":18,"properties":1746,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1747},{"VI":1657},{"title":1749},{"VI":1750},"Harald Hampel",{"url":1644,"publisher":1752,"properties":1774},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1753,"slug":10,"properties":1754,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":1757,"manageAffiliations":1758,"indexDatabases":1759,"url":18,"thumbnailPath":18,"statistic":18,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"issn":1755,"title":1756},{"VOID":13},{"EN":15},[],[],[1760,1767],{"id":102,"indexDatabase":1761,"url":115,"indexYears":116,"academicFieldIds":1766,"indexDatabaseRanking":125},{"id":104,"createTime":105,"updateTime":106,"relativeEntities":1762,"label":1763,"description":1764,"key":112,"publicationTags":1765,"standard":18},[],{"EN":109,"VI":109},{"EN":109,"VI":111},[114],[118,119,120,121,122,123,124],{"id":127,"indexDatabase":1768,"url":142,"indexYears":18,"academicFieldIds":1773,"indexDatabaseRanking":18},{"id":129,"createTime":130,"updateTime":131,"relativeEntities":1769,"label":1770,"description":1771,"key":138,"publicationTags":1772,"standard":18},[],{"EN":134,"VI":134},{"VI":136,"EN":137},[140,141],[144],{"volume":1775,"pages":1777},{"VOID":1776},"11",{"VOID":1778},"58-69","2015-01-01",2015,{"id":1782,"createTime":1783,"updateTime":1784,"relativeEntities":1785,"slug":1786,"properties":1787,"entityType":164,"verifyStatus":17,"verifyTime":1784,"verifyNote":1796,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"primaryUrl":1797,"fullTextUrl":18,"authors":1798,"publicationType":297,"publisherRelationship":1973,"citationCount":18,"citationInfo":18,"publishDate":2000,"publishYear":327,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":328},"725a2c66-7ee1-4a03-a6d6-d202c68081f0","2023-12-09T15:07:16.062+00:00","2025-02-02T23:46:06.892+00:00",[],"Levels-of-tau-protein-in-plasma-are-associated-with-neurodegeneration-and-cognitive-function-in-a-population-based-elderly-cohort",{"references":1788,"abstract":1790,"title":1792,"doi":1794},{"VOID":1789},"10.1016\u002Fj.resuscitation.2012.07.027\n10.1001\u002Fjamaneurol.2014.367\n10.1186\u002Falzrt163\n10.1159\u002F000115751\nNegash S, 2011, Successful aging: definitions and prediction of longevity and conversion to mild cognitive impairment, Am J Geriatr Psychiatry, 19, 581, 10.1097\u002FJGP.0b013e3181f17ec9\n10.1001\u002Farchneur.1991.00530190071018\n10.1212\u002FWNL.43.11.2412-a\nRey A, 1964, L'examen psychologique dans les cas d'encephalopathie traumatique, Arch de Psychol, 28, 286\nWechsler D, 1987, Wechsler Memory Scale—revised manual\nKaplan E, 1983, Boston naming test\nStrauss E, 2006, A compendium of neuropsychological tests: administration, norms, and commentary\n10.2466\u002Fpms.1958.8.3.271\nWechsler D, 1981, Wechsler Adult Intelligence Scale—revised manual\n10.1080\u002F13854049208401877\n10.1002\u002Fana.20009\n10.1016\u002Fj.neuroimage.2005.02.005\n10.1016\u002Fj.neurobiolaging.2009.07.002\n10.3174\u002Fajnr.A2321\n10.2967\u002Fjnumed.108.058529\n10.1016\u002Fj.neuroimage.2014.11.058\n10.1002\u002Fana.22628\n10.1093\u002Fbrain\u002Fawv050\n10.2337\u002Fdc13-0143\n10.1097\u002FNEN.0b013e31825018f7\n10.1002\u002Fana.24546\n10.1371\u002Fjournal.pone.0076523",{"EN":1791},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Introduction\u003C\u002Fjats:title>\u003Cjats:p>Tau protein levels in plasma may be a marker of neuronal damage. We examined associations between plasma tau levels and Alzheimer's disease (AD)–related magnetic resonance imaging (MRI) and positron emission tomography (PET) neuroimaging measures among nondemented individuals.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>Participants included 378 cognitively normal (CN) and 161 mild cognitive impairment (MCI) individuals enrolled in the Mayo Clinic Study of Aging with concurrent neuropsychological measures and amyloid PET, fluorodeoxyglucose PET, and MRI. Baseline plasma tau levels were measured using the Quanterix Simoa‐HD1 tau assay.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Plasma tau levels were higher in MCI compared with CN (4.34 vs. 4.14 pg\u002FmL, \u003Cjats:italic>P\u003C\u002Fjats:italic> = .078). In regression models adjusted for age, gender, education, and \u003Cjats:italic>APOE\u003C\u002Fjats:italic>, higher plasma tau was associated with worse memory performance (b = −0.30, \u003Cjats:italic>P\u003C\u002Fjats:italic> = .02) and abnormal cortical thickness in an AD signature region (odds ratio = 1.80, \u003Cjats:italic>P\u003C\u002Fjats:italic> = .018).\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Discussion\u003C\u002Fjats:title>\u003Cjats:p>Plasma tau is associated with cortical thickness and memory performance. Longitudinal studies will better elucidate the associations between plasma tau, neurodegeneration, and cognition.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":1793},"Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population‐based elderly cohort",{"VOID":1795},"10.1016\u002Fj.jalz.2016.06.001","Author affiliation is blank","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS1552526016300875",[1799,1806,1836,1856,1873,1888,1900,1917,1937,1958],{"id":1800,"sortIndex":274,"researcher":18,"roles":1801,"affiliations":1802,"properties":1803},"de8cd878-05a1-4075-afc2-ccd627c31c38",[173],[],{"title":1804},{"VI":1805},"David C. Airey",{"id":1807,"sortIndex":98,"researcher":18,"roles":1808,"affiliations":1809,"properties":1833},"c0782cc1-2342-4711-b60d-561178c7894c",[173],[1810,1823],{"id":1811,"sortIndex":220,"affiliation":1812,"properties":1821},"f0cb5503-100b-4ef8-8125-6f782867a3ac",{"id":1813,"createTime":1814,"updateTime":1815,"relativeEntities":1816,"slug":1817,"properties":1818,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"e4f02d6c-9841-4a10-9b3a-1dc83446cfc6","2024-08-31T09:17:54.778+00:00","2025-01-29T23:26:00.610+00:00",[],"Department-of-Neurology-Mayo-Clinic-Rochester-MN-USA",{"title":1819},{"EN":1820},"Department of Neurology, Mayo Clinic, Rochester, MN, USA",{"title":1822},{"VI":1820},{"id":18,"sortIndex":19,"affiliation":1824,"properties":18},{"id":1825,"createTime":1826,"updateTime":1827,"relativeEntities":1828,"slug":1829,"properties":1830,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"30e508f4-f196-47e3-9f9a-668fc95489a5","2023-12-06T13:12:09.716+00:00","2024-09-11T11:53:37.502+00:00",[],"Division-of-Epidemiology-Department-of-Health-Sciences-Research-Mayo-Clinic-Rochester-MN-USA",{"title":1831},{"VI":1832},"Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA",{"title":1834},{"VI":1835},"Rosebud O. Roberts",{"id":1837,"sortIndex":19,"researcher":18,"roles":1838,"affiliations":1839,"properties":1853},"7cd7e37f-6986-46b8-89e0-59c67efb35de",[173],[1840],{"id":1841,"sortIndex":19,"affiliation":1842,"properties":1850},"147f66b9-6934-4ca3-9827-f62e9ad70fe5",{"id":1843,"createTime":1844,"updateTime":1844,"relativeEntities":1845,"slug":1846,"properties":1847,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"1f89a2c5-443e-4c0a-91c5-d977609e5f61","2024-09-23T03:05:18.729+00:00",[],"Lilly-Research-Laboratories-Eli-Lilly-and-Company-Indianapolis-IN-United-States",{"title":1848},{"EN":1849},"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United States",{"title":1851},{"VI":1852},"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA",{"title":1854},{"VI":1855},"Jeffrey L. Dage",{"id":1857,"sortIndex":236,"researcher":18,"roles":1858,"affiliations":1859,"properties":1870},"d21b9928-a9cd-4103-b67f-97331695ca0c",[173],[1860],{"id":18,"sortIndex":19,"affiliation":1861,"properties":18},{"id":1862,"createTime":1863,"updateTime":1864,"relativeEntities":1865,"slug":1866,"properties":1867,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"00cc5dc8-91f3-4d38-8312-403e8b63a746","2023-12-03T12:53:11.718+00:00","2025-06-11T14:17:19.029+00:00",[],"Department-of-Radiology-Mayo-Clinic-Rochester-MN-USA",{"title":1868},{"VI":1869},"Department of Radiology, Mayo Clinic, Rochester, MN, USA",{"title":1871},{"VI":1872},"Clifford R. Jack",{"id":1874,"sortIndex":171,"researcher":18,"roles":1875,"affiliations":1876,"properties":1885},"9769112a-302f-4622-b058-1d902a7f49ed",[173],[1877],{"id":1878,"sortIndex":19,"affiliation":1879,"properties":1883},"69573fee-ce08-4dae-ba5b-0146236a5a28",{"id":1813,"createTime":1814,"updateTime":1815,"relativeEntities":1880,"slug":1817,"properties":1881,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1882},{"EN":1820},{"title":1884},{"VI":1820},{"title":1886},{"VI":1887},"David S. Knopman",{"id":1889,"sortIndex":220,"researcher":18,"roles":1890,"affiliations":1891,"properties":1897},"c693a7e0-ceb3-4966-bd34-277de8d24d74",[173],[1892],{"id":18,"sortIndex":19,"affiliation":1893,"properties":18},{"id":1825,"createTime":1826,"updateTime":1827,"relativeEntities":1894,"slug":1829,"properties":1895,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1896},{"VI":1832},{"title":1898},{"VI":1899},"Alexandra M.V. Wennberg",{"id":1901,"sortIndex":261,"researcher":18,"roles":1902,"affiliations":1903,"properties":1914},"570a046a-2f29-49cb-88b0-ef0d78a76dd0",[173],[1904],{"id":18,"sortIndex":19,"affiliation":1905,"properties":18},{"id":1906,"createTime":1907,"updateTime":1908,"relativeEntities":1909,"slug":1910,"properties":1911,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"16a98587-022a-4d4c-8954-4b806d70f3b6","2024-01-28T06:28:03.225+00:00","2024-12-26T20:09:01.131+00:00",[],"Department-of-Psychiatry-and-Psychology-Mayo-Clinic-Rochester-MN-USA",{"title":1912},{"VI":1913},"Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA",{"title":1915},{"VI":1916},"Mary M. Machulda",{"id":1918,"sortIndex":772,"researcher":18,"roles":1919,"affiliations":1920,"properties":1934},"444c5333-154c-4833-86e4-284f573f2b3a",[173],[1921,1929],{"id":1922,"sortIndex":220,"affiliation":1923,"properties":1927},"111b6101-024a-4f0f-b9fe-24ca60da8372",{"id":1813,"createTime":1814,"updateTime":1815,"relativeEntities":1924,"slug":1817,"properties":1925,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1926},{"EN":1820},{"title":1928},{"VI":1820},{"id":18,"sortIndex":19,"affiliation":1930,"properties":18},{"id":1825,"createTime":1826,"updateTime":1827,"relativeEntities":1931,"slug":1829,"properties":1932,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1933},{"VI":1832},{"title":1935},{"VI":1936},"Michelle M. Mielke",{"id":1938,"sortIndex":188,"researcher":18,"roles":1939,"affiliations":1940,"properties":1955},"35aaf90a-5d8f-45e5-b485-063eed531677",[173],[1941],{"id":1942,"sortIndex":19,"affiliation":1943,"properties":1952},"5432057d-4122-4297-a01c-4ed4c37b5adf",{"id":1944,"createTime":1945,"updateTime":1946,"relativeEntities":1947,"slug":1948,"properties":1949,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"07686bb5-3536-458e-ba76-8799afd7b1a4","2024-01-16T23:51:28.429+00:00","2025-06-11T20:26:50.778+00:00",[],"Division-of-Biomedical-Statistics-and-Informatics-Department-of-Health-Sciences-Research-Mayo-Clinic-Rochester-MN-United-States",{"title":1950},{"VI":1951},"Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States",{"title":1953},{"VI":1954},"Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA",{"title":1956},{"VI":1957},"Clinton E. Hagen",{"id":1959,"sortIndex":88,"researcher":18,"roles":1960,"affiliations":1961,"properties":1970},"f77d6669-18ee-4efa-80bf-baa5fff7a872",[173],[1962],{"id":1963,"sortIndex":19,"affiliation":1964,"properties":1968},"16288cf3-3ba5-4770-8553-fbf49f18f97e",{"id":1813,"createTime":1814,"updateTime":1815,"relativeEntities":1965,"slug":1817,"properties":1966,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},[],{"title":1967},{"EN":1820},{"title":1969},{"VI":1820},{"title":1971},{"VI":1972},"Ronald C. 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Available at:http:\u002F\u002Faspe.hhs.gov\u002Fnational‐alzheimers‐project‐act. Accessed December 30 2015.\n10.1016\u002Fj.jalz.2016.01.005\n10.1212\u002FWNL.0b013e31828726f5\n10.1159\u002F000109998\n10.1007\u002Fs12031-011-9538-y\n10.1001\u002Fjamaneurol.2013.3579\n10.1016\u002Fj.jalz.2009.09.001\n10.1159\u002F000017050\n10.1111\u002Fj.1532-5415.1999.tb04580.x\n10.1016\u002FS0895-4356(03)00133-1\nOstbye T, 2008, Identification of dementia: agreement among national survey data, Medicare claims, and death certificates, Health Serv Res, 43, 313\n10.3233\u002FJAD-2009-1099\nCenters for Medicare and Medicaid Services.Chronic Condition Data Warehouse. Available at:https:\u002F\u002Fwww.ccwdata.org\u002Fweb\u002Fguest\u002Fcondition‐categorieshttp:\u002F\u002Fwww.ccwdata.org\u002Findex.htm. Accessed December 30 2015.\nCenters for Medicare & Medicaid Services.What's Medicare?Available at:https:\u002F\u002Fwww.medicare.gov\u002Fsign‐up‐change‐plans\u002Fdecide‐how‐to‐get‐medicare\u002Fwhats‐medicare\u002Fwhat‐is‐medicare.html. Accessed March 10 2016.\nAgency for Healthcare Research and Quality, 2015, Healthcare Cost and Utilization Project (HUCP). Clinical Classifications Software for ICD‐9‐CM\n10.1016\u002FS0895-4356(02)00452-3\n10.2147\u002FCLEP.S37929\n10.3233\u002FJAD-2003-5501\n10.1016\u002Fj.jalz.2010.11.007\n10.1001\u002Farchneur.60.2.185\n10.1159\u002F000087448\nMayeuxR SternY.Epidemiology of Alzheimer disease.Cold Spring Harb Perspect Med.2012;2.\n10.1038\u002Fnrneurol.2011.2\n10.1016\u002Fj.arcmed.2012.11.003\n10.1111\u002Fj.1532-5415.2012.03933.x\n10.1016\u002FS0140-6736(15)00463-8\n10.1093\u002Fbrain\u002Fawr273\n10.1016\u002FS1474-4422(09)70236-4\n10.3109\u002F09540261.2013.776523\n10.1212\u002F01.wnl.0000334277.16896.fa\n10.1186\u002Falzrt157\n10.1159\u002F000071006\n10.1192\u002Fbjp.174.1.45\n10.1016\u002Fj.jalz.2006.03.005\n10.1016\u002Fj.jalz.2005.11.001\n10.1016\u002Fj.neurobiolaging.2009.04.002\nWilliams JBW, 1987, Diagnostic criteria from DSM‐III‐R\n10.1212\u002FWNL.34.7.939\n10.1016\u002Fj.jalz.2011.03.005\n10.1007\u002Fs11606-007-0202-8\nNational Guideline Clearinghouse (NGC), 2015, Diagnosis and treatment\n10.1016\u002Fj.jalz.2012.09.011\nCenters for Medicare & Medicaid Services.Medicare & Medicaid Statistical Supplement 2013 Edition Table 2.2. Available at:https:\u002F\u002Fwww.cms.gov\u002FResearch‐Statistics‐Data‐and‐Systems\u002FStatistics‐Trends‐and‐Reports\u002FMedicareMedicaidStatSupp\u002F2013.html. Accessed December 30 2015.\nUS Department of Health and Human Services.Dementias including Alzheimer's disease.Healthy People 2020. Available at:http:\u002F\u002Fwww.healthypeople.gov\u002F2020\u002Ftopics‐objectives\u002Ftopic\u002Fdementias‐including‐alzheimers‐disease. Accessed December 30 2015.\nUS Department of Health and Human Services.Natl Plan Address Alzheimer's Dis: 2015 Update. Available at:http:\u002F\u002Faspe.hhs.gov\u002Fsites\u002Fdefault\u002Ffiles\u002Fpdf\u002F107031\u002FNatlPlan2015.pdf. Accessed December 30 2015.\nMontineT.Alzheimer's disease‐related dementias: conference and recommendations report to the NINDS Council. Available at:http:\u002F\u002Fwww.ninds.nih.gov\u002Ffunding\u002Fareas\u002Fneurodegeneration\u002Fworkshops\u002Fadrd2013\u002F;2013. Accessed December 30 2015",{"EN":2009},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:title>Introduction\u003C\u002Fjats:title>\u003Cjats:p>Rapid growth of the older adult population requires greater epidemiologic characterization of dementia. We developed national prevalence estimates of diagnosed dementia and subtypes in the highest risk United States (US) population.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>We analyzed Centers for Medicare & Medicaid administrative enrollment and claims data for 100% of Medicare fee‐for‐service beneficiaries enrolled during 2011–2013 and age ≥68 years as of December 31, 2013 (n = 21.6 million).\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Over 3.1 million (14.4%) beneficiaries had a claim for a service and\u002For treatment for any dementia subtype. Dementia not otherwise specified was the most common diagnosis (present in 92.9%). The most common subtype was Alzheimer's (43.5%), followed by vascular (14.5%), Lewy body (5.4%), frontotemporal (1.0%), and alcohol induced (0.7%). The prevalence of other types of diagnosed dementia was 0.2%.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Discussion\u003C\u002Fjats:title>\u003Cjats:p>This study is the first to document concurrent prevalence of primary dementia subtypes among this US population. The findings can assist in prioritizing dementia research, clinical services, and caregiving resources.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":2011},"Prevalence of dementia subtypes in United States Medicare fee‐for‐service beneficiaries, 2011–2013",{"VOID":2013},"10.1016\u002Fj.jalz.2016.04.002","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS1552526016300528",[2016,2033,2061,2076,2100,2112],{"id":2017,"sortIndex":261,"researcher":18,"roles":2018,"affiliations":2019,"properties":2030},"0a7db46f-d069-4b8e-b32a-bfb67264d735",[173],[2020],{"id":18,"sortIndex":19,"affiliation":2021,"properties":18},{"id":2022,"createTime":2023,"updateTime":2024,"relativeEntities":2025,"slug":2026,"properties":2027,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"86214763-eced-41d0-b443-fef271676ce7","2024-04-21T18:17:20.670+00:00","2024-09-12T09:34:13.433+00:00",[],"Centers-for-Medicare-Medicaid-Services-Baltimore-MD-USA",{"title":2028},{"EN":2029},"Centers for Medicare & Medicaid Services, Baltimore, MD, USA",{"title":2031},{"VI":2032},"Shari M. Ling",{"id":2034,"sortIndex":188,"researcher":18,"roles":2035,"affiliations":2036,"properties":2058},"d0f66781-cc53-4d8b-a610-795e36674b68",[173],[2037,2048],{"id":2038,"sortIndex":220,"affiliation":2039,"properties":2047},"0196228e-f134-452c-95b1-a606e8bc4154",{"id":2040,"createTime":2041,"updateTime":2041,"relativeEntities":2042,"slug":2043,"properties":2044,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"84b5bd31-39d2-494c-af17-ee0ae56c2fc4","2024-04-17T08:11:23.140+00:00",[],"Division-of-Neurology-Atlanta-VA-Medical-Center-Atlanta-GA-USA",{"title":2045},{"EN":2046},"Division of Neurology, Atlanta VA Medical Center, Atlanta, GA, USA",{},{"id":18,"sortIndex":19,"affiliation":2049,"properties":18},{"id":2050,"createTime":2051,"updateTime":2052,"relativeEntities":2053,"slug":2054,"properties":2055,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"08ccde82-c02e-4e9e-bdfa-999147a2db68","2023-12-06T23:44:53.198+00:00","2025-06-11T21:46:38.370+00:00",[],"Department-of-Neurology-and-Human-Genetics-Emory-University-School-of-Medicine-Atlanta-GA-USA",{"title":2056},{"VI":2057},"Department of Neurology and Human Genetics, Emory University School of Medicine, Atlanta, GA, USA",{"title":2059},{"VI":2060},"Thomas S. Wingo",{"id":2062,"sortIndex":171,"researcher":18,"roles":2063,"affiliations":2064,"properties":2073},"82a0ba43-3918-4125-a4d6-5068028dd21d",[173],[2065],{"id":18,"sortIndex":19,"affiliation":2066,"properties":18},{"id":2067,"createTime":2068,"updateTime":2068,"relativeEntities":2069,"slug":18,"properties":2070,"entityType":87,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19},"daad425f-a5b2-48d4-94b9-4800e6718ad1","2023-12-06T23:44:48.674+00:00",[],{"title":2071},{"VI":2072},"National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Prevention and Control, Atlanta, GA, USA",{"title":2074},{"VI":2075},"Samuel F. 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