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other provinces and regions in Vietnam and other country.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Address\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Headquarters of Can Tho Journal of Medicine and Pharmacy, located Scientific Research and International Cooperation Office: 179 Nguyen Van Cu Street, An Khanh Ward, Ninh Kieu District, Can Tho City, Vietnam.\u003C\u002Fspan>\u003C\u002Fp>","\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Ngày 16\u002F7\u002F2015, Tạp chí Y Dược học Cần Thơ được cấp chỉ số quốc tế: ISSN 2354-1210.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 4\u002F2016, Tạp chí đã được Hội đồng Giáo sư ngành Y đưa vào danh sách các tạp chí khoa học Y học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Năm 2020 Tạp chí Y Dược học Cần Thơ đã được phê duyệt vào danh mục của các Hội đồng Giáo sư ngành Dược học được tính điểm công trình 0-0,5 điểm cho một bài báo đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ ra 12 số\u002Fnăm, 180-200 trang\u002Fsố.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Từ tháng 12\u002F2022 Tạp chí Y Dược học Cần Thơ là thành viên của hệ thống Crossref và từ tháng 01\u002F2023 tạp chí thực hiện bình duyệt online kín 2 chiều nhằm tăng tính minh bạch, tin cậy của các công trình nghiên cứu khoa học và đảm bảo tốt nhất chất lượng khoa học của bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ, mục đích và phạm vi của tạp chí\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tôn chỉ và mục đích hoạt động của tạp chí: xuất bản nhằm mục đích phổ biến kết quả từ các đề tài nghiên cứu khoa học; giao lưu trao đổi khoa học, chia sẻ kinh nghiệm, học tập, đồng thời cập nhật thông tin khoa học mới trong các lĩnh vực y, sinh, dược học trong và ngoài nước.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phạm vi của tạp chí: Tạp chí xuất bản được chia thành 3 chuyên mục: (i) Bài báo nghiên cứu khoa học là kết quả công trình nghiên cứu khoa học có giá trị đã được triển khai nghiên cứu, (ii) Bài tổng quan y, sinh, dược học: phục vụ mục tiêu đào tạo liên tục trong lĩnh vực y, sinh, dược học; nhằm hệ thống hóa những kiến thức kinh điển và hiện đại; (iii) Thông tin cập nhật kiến thức mới về y, sinh, dược học trong nước và trên thế giới.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Chính sách truy cập mở\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ áp dụng chính sách truy cập mở đối với các bài báo đã xuất bản đến với độc giả, nhằm mở rộng cơ hội tiếp cận các kết quả nghiên cứu chất lượng cao và tăng cường trao đổi kiến thức. Tạp chí đăng tải trực tuyến (miễn phí) toàn văn các bài báo được công bố trên website của Tạp chí (https:\u002F\u002Ftapchi.ctump.edu.vn).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đạo đức xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ cam kết tuân thủ đạo đức xuất bản phù hợp với các hướng dẫn và tiêu chuẩn của the Committee on Publication Ethics (COPE), tuân thủ các nguyên tắc của COPE’s Core Practices, Best Practices Guidelines for Journal Editors và Guidelines on Good Publication Practices.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Bản thảo bài báo chỉ được chấp nhận khi được tác giả chịu trách nhiệm chính cam kết các nội dung sau: Các nội dung của bản thảo chưa được đăng tải toàn bộ hoặc một phần ở các tạp chí khác; Tất cả các tác giả đều có đóng góp một cách đáng kể vào quá trình nghiên cứu hoặc chuẩn bị bản thảo và cùng chịu trách nhiệm về các nội dung của bản thảo; Tuân thủ các biện pháp đảm bảo đạo đức nghiên cứu (ví dụ thỏa thuận đồng ý tham gia nghiên cứu).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Cam kết bảo mật\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí cam kết thực hiện và tuân thủ các quy định của luật và các văn bản hướng dẫn liên quan đến bảo mật thông tin cá nhân trên không gian mạng. Các thông tin mà người dùng (tác giả, độc giả, biên tập viên, người phản biện) nhập vào các biểu mẫu trên Hệ thống Quản lý xuất bản trực tuyến của tạp chí chỉ được sử dụng vào các mục đích đã được tuyên bố rõ ràng và sẽ không được cung cấp cho bất kỳ bên thứ ba nào khác, hay dùng vào bất kỳ mục đích nào khác.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Phí gửi bài\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng bài: 1.000.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Lệ phí gửi đăng nhanh: 1.500.000đ\u002Fbài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với tác giả là cán bộ viên chức thuộc Trường Đại học Y Dược Cần Thơ thì được hỗ trợ 50% lệ phí gửi đăng bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Đối với sinh viên thực hiện đề tài nghiên cứu khoa học cấp trường được hỗ trợ 100% lệ phí đăng bài ( Tác giả gửi đính kèm “ Quyết định về việc giao tổ chức thực hiện đề tài nghiên cứu khoa học cấp Trường của sinh viên”).\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Hình thức nộp lệ phí:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Tiền mặt:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Nộp trực tiếp tại Phòng Tài chính - Kế toán, Trường Đại học Y Dược Cần Thơ, số 179 Nguyễn Văn Cừ, P. An Khánh, Q. Ninh Kiều, thành phố Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Chuyển khoản:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tên Tài khoản: Trường ĐHYD Cần Thơ, Số TK: 0111000115668, tại ngân hàng Vietcombank chi nhánh Cần Thơ.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Thời gian: Áp dụng từ ngày 01\u002F02\u002F2023.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">* Phí gửi bài không được hoàn trả khi bài viết bị từ chối hoặc tác giả xin rút bài viết.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Quy trình phản biện bài báo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tạp chí Y Dược học Cần Thơ thực hiện quy trình phản biện kín hai chiều nghiêm ngặt. Danh tính của những người phản biện không được tiết lộ cho các tác giả và ngược lại. Quy trình thẩm định bài báo đăng gồm các bước sau:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tiếp nhận bản thảo\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Tác giả liên hệ gửi bản thảo đến Tạp chí qua hệ thống trực tuyến tại website: https:\u002F\u002Ftapchi.ctump.edu.vn. Hướng dẫn về cách đăng ký, gửi bài và chuẩn bị bản thảo được cung cấp trên website của Tạp chí.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sàng lọc sơ bộ\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Sau khi Tòa soạn nhận được bài báo của tác giả, Ban Thư ký sẽ tiến hành kiểm tra sơ bộ bài báo (các yêu cầu về nội dung và hình thức). Những bài báo không đúng quy cách hoặc có nội dung không phù hợp hoặc vi phạm bản quyền sẽ bị từ chối (Ban Thư ký thông báo phản hồi đến tác giả trong vòng 1 tuần). Những bài báo đủ điều kiện, được Ban Thư ký tòa soạn chuyển đến Ban Biên tập có cùng chuyên môn với nội dung bài báo để đề xuất người phản biện. Thời gian kể từ khi Ban Biên tập nhận bài báo đến khi đề xuất người phản biện bài báo chậm nhất là 5 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Vòng phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký gửi bài và yêu cầu phản biện đến 02 phản biện độc lập.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Các phản biện gởi nhận xét cho Ban Thư ký. Thời gian từ khi gửi bài cho phản biện đến khi nhận ý kiến của phản biện tối đa là 20 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xử ký kết quả phản biện\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Nếu ý kiến đồng ý cho đăng và không cần chỉnh sửa, Ban Thư ký tiếp tục đăng bài theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Nếu ý kiến đồng ý đăng và cần chỉnh sửa, Ban Thư ký sẽ thông tin đến tác giả chỉnh sửa theo yêu cầu của người phản biện. Thời gian chỉnh sửa và gửi lại kéo dài không quá 2 tuần, từ khi tác giả bài báo nhận được thông tin (Quá trình này có thể lặp lại tối đa 2 lần\u002F1 bài báo). Khi có sự thống nhất, đồng ý của người phản biện; bài báo được tiếp tục đăng theo qui trình.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Những bài báo có chất lượng không đạt yêu cầu, cả 2 phản biện không đồng ý cho đăng sẽ bị Tòa soạn từ chối đăng.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">Xuất bản\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">1. Ban Thư ký tổng hợp các bản thảo đã được tác giả hoàn thiện sau thẩm định trình Ban Biên tập xem xét, Tổng Biên tập phê duyệt, quyết định bài đăng theo các tiêu chí: sự phù hợp nội dung với tôn chỉ và mục đích, thể loại bài viết (ưu tiên các bài có bài có nghiên cứu chuyên sâu, hàm lượng khoa học cao), đóng góp mới bài báo, bài báo được ưu tiên đăng trong số gần nhất của Tạp chí theo thứ tự: tính thời sự, chất lượng bài báo và thời gian gửi bài.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">2. Ban Biên tập và Ban Thư ký biên tập bản thảo, chế bản, đọc rà soát lỗi. Thời gian hoàn thành từ 10-15 ngày.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">3. Ban Thư ký có trách nhiệm thông báo cho tác giả bài báo (bằng e-mail) về tình hình phê duyệt bài báo, thời gian, số kỳ, tập xuất bản bài báo theo qui định.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(0, 0, 0);\">4. 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2011, the National Institute on Aging and Alzheimer's Association created separate diagnostic recommendations for the preclinical, mild cognitive impairment, and dementia stages of Alzheimer's disease. Scientific progress in the interim led to an initiative by the National Institute on Aging and Alzheimer's Association to update and unify the 2011 guidelines. This unifying update is labeled a “research framework” because its intended use is for observational and interventional research, not routine clinical care. In the National Institute on Aging and Alzheimer's Association Research Framework, Alzheimer's disease (AD) is defined by its underlying pathologic processes that can be documented by postmortem examination or \u003Cjats:italic>in vivo\u003C\u002Fjats:italic> by biomarkers. The diagnosis is not based on the clinical consequences of the disease (i.e., symptoms\u002Fsigns) in this research framework, which shifts the definition of AD in living people from a syndromal to a biological construct. The research framework focuses on the diagnosis of AD with biomarkers in living persons. Biomarkers are grouped into those of β amyloid deposition, pathologic tau, and neurodegeneration [AT(N)]. This ATN classification system groups different biomarkers (imaging and biofluids) by the pathologic process each measures. The AT(N) system is flexible in that new biomarkers can be added to the three existing AT(N) groups, and new biomarker groups beyond AT(N) can be added when they become available. We focus on AD as a continuum, and cognitive staging may be accomplished using continuous measures. However, we also outline two different categorical cognitive schemes for staging the severity of cognitive impairment: a scheme using three traditional syndromal categories and a six‐stage numeric scheme. It is important to stress that this framework seeks to create a common language with which investigators can generate and test hypotheses about the interactions among different pathologic processes (denoted by biomarkers) and cognitive symptoms. We appreciate the concern that this biomarker‐based research framework has the potential to be misused. Therefore, we emphasize, first, it is premature and inappropriate to use this research framework in general medical practice. Second, this research framework should not be used to restrict alternative approaches to hypothesis testing that do not use biomarkers. There will be situations where biomarkers are not available or requiring them would be counterproductive to the specific research goals (discussed in more detail later in the document). Thus, biomarker‐based research should not be considered a template for all research into age‐related cognitive impairment and dementia; rather, it should be applied when it is fit for the purpose of the specific research goals of a study. Importantly, this framework should be examined in diverse populations. Although it is possible that β‐amyloid plaques and neurofibrillary tau deposits are not causal in AD pathogenesis, it is \u003Cjats:bold>these abnormal protein deposits\u003C\u002Fjats:bold> that \u003Cjats:bold>define AD as a unique neurodegenerative disease\u003C\u002Fjats:bold> among different disorders that can lead to dementia. We envision that defining AD as a biological construct will enable a more accurate characterization and understanding of the sequence of events that lead to cognitive impairment that is associated with AD, as well as the multifactorial etiology of dementia. This approach also will enable a more precise approach to interventional trials where specific pathways can be targeted in the disease process and in the appropriate people.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:label\u002F>\u003Cjats:p>Vào năm 2011, Viện Quốc gia về Lão hóa và Hiệp hội Alzheimer đã tạo ra những khuyến nghị chẩn đoán riêng cho các giai đoạn tiền lâm sàng, suy giảm nhận thức nhẹ và chứng mất trí nhớ của bệnh Alzheimer. Những tiến bộ khoa học trong khoảng thời gian này đã dẫn đến một sáng kiến của Viện Quốc gia về Lão hóa và Hiệp hội Alzheimer để cập nhật và hợp nhất các hướng dẫn năm 2011. Cập nhật hợp nhất này được gán nhãn là \"khung nghiên cứu\" vì mục đích sử dụng của nó là cho nghiên cứu quan sát và can thiệp, không phải chăm sóc lâm sàng thường quy. Trong Khung Nghiên cứu của Viện Quốc gia về Lão hóa và Hiệp hội Alzheimer, bệnh Alzheimer (AD) được định nghĩa bởi các quá trình bệnh lý cơ bản mà có thể được tài liệu hóa qua khám nghiệm sau khi tử vong hoặc \u003Cjats:italic>in vivo\u003C\u002Fjats:italic> thông qua các chất đánh dấu sinh học. Chẩn đoán không dựa trên các hậu quả lâm sàng của bệnh (tức là, triệu chứng\u002Fdấu hiệu) trong khung nghiên cứu này, điều này chuyển định nghĩa về AD ở người sống từ một cấu trúc hội chứng sang một cấu trúc sinh học. Khung nghiên cứu tập trung vào chẩn đoán AD bằng các chất đánh dấu sinh học ở người sống. Các chất đánh dấu được nhóm thành những chất liên quan đến sự lắng đọng β amyloid, tau bệnh lý và thoái hóa thần kinh [AT(N)]. Hệ thống phân loại AT(N) nhóm các chất đánh dấu khác nhau (hình ảnh và dịch sinh học) theo quá trình bệnh lý mà mỗi chất đo lường. Hệ thống AT(N) linh hoạt ở chỗ các chất đánh dấu mới có thể được thêm vào ba nhóm AT(N) hiện có, và các nhóm chất đánh dấu mới ngoài AT(N) có thể được đưa vào khi chúng có sẵn. Chúng tôi tập trung vào AD như một tiếp diễn, và phân đoạn nhận thức có thể được thực hiện bằng cách sử dụng các biện pháp liên tục. Tuy nhiên, chúng tôi cũng phác thảo hai sơ đồ phân đoạn nhận thức phân loại khác nhau cho mức độ nghiêm trọng của suy giảm nhận thức: một sơ đồ sử dụng ba loại hội chứng truyền thống và một sơ đồ số sáu giai đoạn. Điều quan trọng là nhấn mạnh rằng khung này nhằm tạo ra một ngôn ngữ chung mà các nhà nghiên cứu có thể tạo ra và kiểm tra các giả thuyết về sự tương tác giữa các quá trình bệnh lý khác nhau (được biểu thị bởi các chất đánh dấu) và các triệu chứng nhận thức. Chúng tôi đánh giá cao mối quan ngại rằng khung nghiên cứu dựa trên chất đánh dấu sinh học có khả năng bị lạm dụng. Do đó, chúng tôi nhấn mạnh rằng trước hết, còn quá sớm và không phù hợp để sử dụng khung nghiên cứu này trong thực hành y tế chung. Thứ hai, khung nghiên cứu này không nên được sử dụng để hạn chế các phương pháp thử nghiệm giả thuyết thay thế không sử dụng các chất đánh dấu sinh học. Sẽ có những tình huống mà các chất đánh dấu không có sẵn hoặc yêu cầu chúng có thể phản tác dụng đối với các mục tiêu nghiên cứu cụ thể (được thảo luận chi tiết hơn sau trong tài liệu). Do đó, nghiên cứu dựa trên chất đánh dấu sinh học không nên được coi là khuôn mẫu cho tất cả các nghiên cứu về suy giảm nhận thức liên quan đến tuổi tác và chứng mất trí nhớ; thay vào đó, nó nên được áp dụng khi nó phù hợp với mục đích của các mục tiêu nghiên cứu cụ thể của một nghiên cứu. Quan trọng là, khung này nên được xem xét trong các quần thể đa dạng. Mặc dù có khả năng rằng các mảng β-amyloid và các lắng đọng tau thần kinh không gây ra bệnh lý trong sự phát sinh bệnh AD, nhưng chính \u003Cjats:bold>những lắng đọng protein bất thường này\u003C\u002Fjats:bold> \u003Cjats:bold>định nghĩa AD như một bệnh thoái hóa thần kinh độc đáo\u003C\u002Fjats:bold> giữa các rối loạn khác có thể dẫn đến chứng mất trí nhớ. Chúng tôi hình dung rằng việc định nghĩa AD như một cấu trúc sinh học sẽ cho phép một cách đặc trưng và hiểu biết chính xác hơn về chuỗi sự kiện dẫn đến suy giảm nhận thức liên quan đến AD, cũng như nguyên nhân đa yếu tố của chứng mất trí nhớ. Cách tiếp cận này cũng sẽ tạo điều kiện cho một cách tiếp cận chính xác hơn đối với các thử nghiệm can thiệp nơi các con đường cụ thể có thể được nhắm đến trong quá trình bệnh và trong các đối tượng phù hợp.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":814,"VI":815},"NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease","Khung Nghiên cứu NIA-AA: Hướng tới một định nghĩa sinh học về bệnh Alzheimer",{"VOID":817},"29653606",{"VOID":819},"10.1016\u002Fj.jalz.2018.02.018","PUBLICATION","Auto 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USA",{"id":842,"sortIndex":111,"affiliation":843,"properties":26},"e0892732-257b-4b2e-a934-2332eab43fb1",{"id":844,"createTime":845,"updateTime":845,"relativeEntities":846,"slug":847,"properties":848,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"a6d588f9-3ad8-41b6-933a-52c59acc5a5a","2024-09-17T12:02:24.884+00:00",[],"Office-of-Drug-Evaluation-FDA-Silver-Spring-MD-USA",{"title":849},{"EN":850},"Office of Drug Evaluation FDA  Silver Spring MD USA",{"id":852,"sortIndex":114,"affiliation":853,"properties":26},"4acdf63c-f824-45d9-9414-2ffdb92cc3a1",{"id":854,"createTime":855,"updateTime":856,"relativeEntities":857,"slug":858,"properties":859,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"00cc5dc8-91f3-4d38-8312-403e8b63a746","2023-12-03T12:53:11.718+00:00","2025-06-11T14:17:19.029+00:00",[],"Department-of-Radiology-Mayo-Clinic-Rochester-MN-USA",{"title":860},{"VI":861},"Department of Radiology, Mayo Clinic, Rochester, MN, USA",{"id":863,"sortIndex":115,"affiliation":864,"properties":26},"8c2d3d90-88df-4967-80e0-bb09c15aa1ff",{"id":865,"createTime":866,"updateTime":867,"relativeEntities":868,"slug":869,"properties":870,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"cc6f2256-9933-43ba-b045-90a006740e65","2024-02-08T19:20:22.737+00:00","2024-09-17T12:02:24.872+00:00",[],"Department-of-Psychiatry-and-Neurochemistry-University-of-Gothenburg-Gothenburg-Sweden",{"title":871},{"VI":872},"Department of Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg, Sweden",{"id":874,"sortIndex":59,"affiliation":875,"properties":26},"ee09a5a2-a68d-4698-9db6-6f3863ecab71",{"id":876,"createTime":877,"updateTime":877,"relativeEntities":878,"slug":879,"properties":880,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"dab57587-975f-493c-8808-191e2824b82a","2024-09-17T12:02:24.878+00:00",[],"Medical-amp-Scientific-Relations-Alzheimer-s-Association-Chicago-IL-USA",{"title":881},{"EN":882},"Medical & Scientific Relations Alzheimer's Association  Chicago IL USA",{"openalex":884,"title":886},{"VOID":885},"A5013037739",{"EN":887},"Cerise 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This long “preclinical” phase of AD would provide a critical opportunity for therapeutic intervention; however, we need to further elucidate the link between the pathological cascade of AD and the emergence of clinical symptoms. The National Institute on Aging and the Alzheimer's Association convened an international workgroup to review the biomarker, epidemiological, and neuropsychological evidence, and to develop recommendations to determine the factors which best predict the risk of progression from “normal” cognition to mild cognitive impairment and AD dementia. We propose a conceptual framework and operational research criteria, based on the prevailing scientific evidence to date, to test and refine these models with longitudinal clinical research studies. These recommendations are solely intended for research purposes and do not have any clinical implications at this time. It is hoped that these recommendations will provide a common rubric to advance the study of preclinical AD, and ultimately, aid the field in moving toward earlier intervention at a stage of AD when some disease‐modifying therapies may be most efficacious.\u003C\u002Fjats:p>","\u003Cjats:p>Quá trình sinh bệnh lý của bệnh Alzheimer (AD) được cho là bắt đầu nhiều năm trước khi chẩn đoán bệnh mất trí nhớ do AD. Giai đoạn \"tiền lâm sàng\" kéo dài này của AD sẽ cung cấp một cơ hội quan trọng cho can thiệp điều trị; tuy nhiên, chúng ta cần làm rõ thêm mối liên hệ giữa chuỗi bệnh lý của AD và sự xuất hiện của các triệu chứng lâm sàng. Viện Quốc gia về Lão hóa và Hiệp hội Alzheimer đã triệu tập một nhóm làm việc quốc tế để xem xét các bằng chứng về biomarker, dịch tễ học và tâm lý thần kinh, và để phát triển các khuyến nghị nhằm xác định các yếu tố nào dự đoán tốt nhất nguy cơ tiến triển từ nhận thức \"bình thường\" sang suy giảm nhận thức nhẹ và bệnh mất trí nhớ do AD. Chúng tôi đề xuất một khung khái niệm và các tiêu chí nghiên cứu hoạt động, dựa trên các bằng chứng khoa học hiện có cho đến nay, để kiểm tra và tinh chỉnh các mô hình này thông qua các nghiên cứu lâm sàng theo chiều dọc. Những khuyến nghị này chỉ nhằm mục đích nghiên cứu và hiện tại không có bất kỳ ý nghĩa lâm sàng nào. Hy vọng rằng những khuyến nghị này sẽ cung cấp một khuôn khổ chung để thúc đẩy nghiên cứu về bệnh AD tiền lâm sàng và cuối cùng, hỗ trợ lĩnh vực này trong việc tiến tới can thiệp sớm ở giai đoạn của AD khi một số liệu pháp làm thay đổi bệnh có thể hiệu quả nhất.\u003C\u002Fjats:p>",{"EN":2643,"VI":2644},"Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","Hướng tới xác định các giai đoạn tiền lâm sàng của bệnh Alzheimer: Khuyến nghị từ các nhóm làm việc của Viện Quốc gia về Lão hóa - Hiệp hội Alzheimer về hướng dẫn chẩn đoán bệnh Alzheimer",{"VOID":2646},"21514248",{"VOID":1938},"2024-08-31T09:17:59.469+00:00",[102],[101],"https:\u002F\u002Falz-journals.onlinelibrary.wiley.com\u002Fdoi\u002F10.1016\u002Fj.jalz.2011.03.003",[2653,2673,2695,2714,2736,2757,2779,2792,2810,2825,2843,2862,2881,2902,2924,2946,2977,2996,3011,3032,3053],{"id":2654,"sortIndex":234,"researcher":26,"roles":2655,"affiliations":2656,"properties":2668},"3cc2f056-9950-410c-a923-a5e192b9900a",[],[2657],{"id":2658,"sortIndex":36,"affiliation":2659,"properties":26},"cee4842d-6b82-480b-9e27-3b0850efdd23",{"id":2660,"createTime":2661,"updateTime":2662,"relativeEntities":2663,"slug":2664,"properties":2665,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"314229e4-ef7f-4c65-bef8-966050388c8c","2024-01-08T16:08:40.244+00:00","2024-08-31T09:17:59.643+00:00",[],"Division-of-Neuroscience-National-Institute-on-Aging-Bethesda-MD-USA",{"title":2666},{"VI":2667},"Division of Neuroscience, National Institute on Aging, Bethesda, MD, USA",{"openalex":2669,"title":2671},{"VOID":2670},"A5019444213",{"EN":2672},"Molly V. 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DRentz JSCarmasin THedden IHamdi RLBuckner et al.Amyloid deposition and brain volume across the continuum of aging and AD.Ann Neurol2011(in press)",{},{"id":26,"text":3257,"url":26,"identifiers":3258},"10.1016\u002Fj.neuroimage.2010.10.027",{"doi":3257},{"id":26,"text":3260,"url":26,"identifiers":3261},"Pike KE, 2007, Beta‐amyloid imaging and memory in non‐demented individuals: evidence for preclinical Alzheimer's disease, Brain, 130, 2837, 10.1093\u002Fbrain\u002Fawm238",{"doi":3262},"10.1093\u002Fbrain\u002Fawm238",{"id":26,"text":3264,"url":26,"identifiers":3265},"10.1093\u002Fbrain\u002Fawn320",{"doi":3264},{"id":26,"text":2141,"url":26,"identifiers":3267},{"doi":2141},{"id":26,"text":2478,"url":26,"identifiers":3269},{"doi":2478},{"id":26,"text":1965,"url":26,"identifiers":3271},{"doi":1965},{"id":26,"text":3273,"url":26,"identifiers":3274},"JMSchott JWBartlett NCFox JBarnes;Investigators ftAsDNI. Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1‐42.Ann Neurol 2011 (in press).",{"doi":3275},"10.1002\u002Fana.22315",{"id":26,"text":2162,"url":26,"identifiers":3277},{"doi":2162},{"id":26,"text":3279,"url":26,"identifiers":3280},"10.1212\u002F01.wnl.0000267428.62582.aa",{"doi":3279},{"id":26,"text":3282,"url":26,"identifiers":3283},"10.1001\u002Farchneurol.2009.272",{"doi":3282},{"id":26,"text":1944,"url":26,"identifiers":3285},{"doi":1944},{"id":26,"text":3287,"url":26,"identifiers":3288},"10.1001\u002Farchneurol.2009.269",{"doi":3287},{"id":26,"text":3290,"url":26,"identifiers":3291},"10.1016\u002Fj.neuropsychologia.2008.02.008",{"doi":3290},{"id":26,"text":3293,"url":26,"identifiers":3294},"10.1093\u002Fbrain\u002Fawq383",{"doi":3293},{"id":26,"text":3296,"url":26,"identifiers":3297},"10.1212\u002FWNL.0b013e3181af79fb",{"doi":3296},{"id":26,"text":3299,"url":26,"identifiers":3300},"10.1001\u002Fjama.2010.1995",{"doi":3299},{"id":26,"text":3302,"url":26,"identifiers":3303},"10.1017\u002FS1355617708080375",{"doi":3302},{"id":26,"text":3305,"url":26,"identifiers":3306},"10.1002\u002Fana.21610",{"doi":3305},{"id":26,"text":2288,"url":26,"identifiers":3308},{"doi":2288},{"id":26,"text":3310,"url":26,"identifiers":3311},"10.1007\u002FBF00308809",{"doi":3310},{"id":26,"text":3313,"url":26,"identifiers":3314},"10.1001\u002Fjama.1995.03520410048025",{"doi":3313},{"id":26,"text":3316,"url":26,"identifiers":3317},"10.1212\u002FWNL.54.5.1109",{"doi":3316},{"id":26,"text":3319,"url":26,"identifiers":3320},"10.1001\u002Farchneur.59.11.1737",{"doi":3319},{"id":3322,"createTime":3323,"updateTime":3324,"relativeEntities":3325,"slug":3326,"properties":3327,"entityType":820,"verifyStatus":28,"verifyTime":3323,"verifyNote":3344,"syncStatus":28,"languages":3345,"translateLanguages":3346,"viewCount":36,"primaryUrl":3347,"fullTextUrl":26,"authors":3348,"publicationType":1884,"publisherRelationship":3355,"citationCount":3384,"citationInfo":3385,"publishDate":3395,"publishYear":3396,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":3397,"isForceReanalyzing":2624},"2cdef8a7-70ea-40ad-b2b8-28ca43c4e9b4","2024-10-01T07:40:31.987+00:00","2025-02-06T09:38:26.806+00:00",[],"2016-Alzheimer-s-disease-facts-and-figures",{"mag":3328,"keywords":3330,"openalex":3332,"abstract":3334,"title":3337,"pm":3340,"doi":3342},{"VOID":3329},"3014251530",{"VI":3331},"bệnh Alzheimer, sức khỏe cộng đồng, tác động tài chính, chăm sóc dài hạn, sa sút trí tuệ",{"VOID":3333},"W3014251530",{"EN":3335,"VI":3336},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:label\u002F>\u003Cjats:p>This report describes the public health impact of Alzheimer's disease, including incidence and prevalence, mortality rates, costs of care, and the overall impact on caregivers and society. It also examines in detail the financial impact of Alzheimer's on families, including annual costs to families and the difficult decisions families must often make to pay those costs. An estimated 5.4 million Americans have Alzheimer's disease. By mid‐century, the number of people living with Alzheimer's disease in the United States is projected to grow to 13.8 million, fueled in large part by the aging baby boom generation. Today, someone in the country develops Alzheimer's disease every 66 seconds. By 2050, one new case of Alzheimer's is expected to develop every 33 seconds, resulting in nearly 1 million new cases per year. In 2013, official death certificates recorded 84,767 deaths from Alzheimer's disease, making it the sixth leading cause of death in the United States and the fifth leading cause of death in Americans age ≥65 years. Between 2000 and 2013, deaths resulting from stroke, heart disease, and prostate cancer decreased 23%, 14%, and 11%, respectively, whereas deaths from Alzheimer's disease increased 71%. The actual number of deaths to which Alzheimer's disease contributes is likely much larger than the number of deaths from Alzheimer's disease recorded on death certificates. In 2016, an estimated 700,000 Americans age ≥65 years will die with Alzheimer's disease, and many of them will die because of the complications caused by Alzheimer's disease. In 2015, more than 15 million family members and other unpaid caregivers provided an estimated 18.1 billion hours of care to people with Alzheimer's and other dementias, a contribution valued at more than $221 billion. Average per‐person Medicare payments for services to beneficiaries age ≥65 years with Alzheimer's disease and other dementias are more than two and a half times as great as payments for all beneficiaries without these conditions, and Medicaid payments are 19 times as great. Total payments in 2016 for health care, long‐term care and hospice services for people age ≥65 years with dementia are estimated to be $236 billion. The costs of Alzheimer's care may place a substantial financial burden on families, who often have to take money out of their retirement savings, cut back on buying food, and reduce their own trips to the doctor. In addition, many family members incorrectly believe that Medicare pays for nursing home care and other types of long‐term care. Such findings highlight the need for solutions to prevent dementia‐related costs from jeopardizing the health and financial security of the families of people with Alzheimer's and other dementias.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>","\u003Cjats:title>Tóm tắt\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:label\u002F>\u003Cjats:p>Bài báo này mô tả tác động của bệnh Alzheimer đối với sức khỏe cộng đồng, bao gồm tỷ lệ mắc và tỷ lệ lưu hành, tỷ lệ tử vong, chi phí chăm sóc và tác động chung lên người chăm sóc cũng như xã hội. Bài báo cũng xem xét chi tiết tác động tài chính của bệnh Alzheimer đối với các gia đình, bao gồm chi phí hàng năm và những quyết định khó khăn mà các gia đình thường phải đưa ra để chi trả cho các chi phí đó. Ước tính có khoảng 5,4 triệu người Mỹ mắc bệnh Alzheimer. Đến giữa thế kỷ này, số người sống với bệnh Alzheimer ở Hoa Kỳ dự kiến sẽ tăng lên 13,8 triệu, phần lớn do sự lão hóa của thế hệ baby boom. Hiện nay, ở Hoa Kỳ, cứ mỗi 66 giây sẽ có một người phát triển bệnh Alzheimer. Đến năm 2050, dự kiến sẽ có một ca bệnh Alzheimer mới được phát hiện mỗi 33 giây, dẫn đến gần 1 triệu ca bệnh mới mỗi năm. Năm 2013, các giấy chứng tử chính thức ghi nhận 84,767 ca tử vong do bệnh Alzheimer, khiến đây trở thành nguyên nhân thứ sáu gây tử vong ở Hoa Kỳ và thứ năm đối với người Mỹ từ 65 tuổi trở lên. Trong khoảng thời gian từ năm 2000 đến 2013, số ca tử vong do đột quỵ, bệnh tim và ung thư tuyến tiền liệt giảm lần lượt 23%, 14% và 11%, trong khi số ca tử vong do bệnh Alzheimer tăng 71%. Số ca tử vong do bệnh Alzheimer gây ra thực tế có thể lớn hơn nhiều so với số ca tử vong do bệnh Alzheimer được ghi nhận trên giấy chứng tử. Năm 2016, dự kiến khoảng 700,000 người Mỹ trên 65 tuổi sẽ chết do bệnh Alzheimer, và nhiều người trong số họ sẽ tử vong do các biến chứng do bệnh Alzheimer gây ra. Năm 2015, hơn 15 triệu thành viên gia đình và các người chăm sóc không được trả lương đã cung cấp khoảng 18,1 triệu giờ chăm sóc cho những người mắc bệnh Alzheimer và các dạng sa sút trí tuệ khác, với giá trị ước tính trên 221 tỷ USD. Mức thanh toán trung bình theo đầu người của Medicare cho các dịch vụ cho những người thụ hưởng từ 65 tuổi trở lên mắc bệnh Alzheimer và các dạng sa sút trí tuệ khác lớn hơn gấp hai lần rưỡi so với thanh toán cho tất cả các thụ hưởng không mắc các điều kiện này, và mức thanh toán của Medicaid cao gấp 19 lần. Tổng chi phí năm 2016 cho chăm sóc sức khỏe, chăm sóc dài hạn và các dịch vụ chăm sóc y tế tận nhà cho những người từ 65 tuổi trở lên mắc bệnh sa sút trí tuệ ước tính là 236 tỷ USD. Chi phí chăm sóc bệnh Alzheimer có thể đặt gánh nặng tài chính nặng nề lên các gia đình, những người thường phải rút tiền từ tiết kiệm hưu trí, cắt giảm việc mua thực phẩm và giảm chuyến thăm bác sĩ của chính mình. Hơn nữa, nhiều thành viên trong gia đình hiểu sai rằng Medicare sẽ chi trả cho việc chăm sóc tại viện dưỡng lão và các loại chăm sóc dài hạn khác. Những phát hiện này nhấn mạnh sự cần thiết phải tìm ra các giải pháp để ngăn chặn các chi phí liên quan đến sa sút trí tuệ làm nguy hiểm sức khỏe và an ninh tài chính của các gia đình có người mắc bệnh Alzheimer và các dạng sa sút trí tuệ khác.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":3338,"VI":3339},"2016 Alzheimer's disease facts and figures","Thông tin và số liệu về bệnh Alzheimer năm 2016",{"VOID":3341},"27570871",{"VOID":3343},"10.1016\u002Fj.jalz.2016.03.001","Author title is 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Accessed December 14 2015.",{},{"id":26,"text":4353,"url":26,"identifiers":4354},"10.1007\u002Fs11606-014-2916-8",{"doi":4353},{"id":26,"text":4356,"url":26,"identifiers":4357},"10.1016\u002Fj.jalz.2015.01.007",{"doi":4356},{"id":26,"text":4359,"url":26,"identifiers":4360},"10.1177\u002F1533317513488911",{"doi":4359},{"id":26,"text":4362,"url":26,"identifiers":4363},"10.1007\u002Fs40258-013-0038-9",{"doi":4362},{"id":26,"text":4365,"url":26,"identifiers":4366},"10.1212\u002FWNL.0b013e31829d8599",{"doi":4365},{"id":26,"text":4368,"url":26,"identifiers":4369},"10.1016\u002Fj.jalz.2012.11.002",{"doi":4368},{"id":26,"text":4371,"url":26,"identifiers":4372},"10.1161\u002FCIRCHEARTFAILURE.114.001438",{"doi":4371},{"id":26,"text":4374,"url":26,"identifiers":4375},"Genworth Financial Inc.Genworth 2015 Cost of Care Survey.Home Care Providers Adult Day Health Care Facilities Assisted Living Facilities and Nursing Homes. Available at:https:\u002F\u002Fwww.genworth.com\u002Fdam\u002FAmericas\u002FUS\u002FPDFs\u002FConsumer\u002Fcorporate\u002F130568_040115_gnw.pdf. Accessed November 6 2015.",{},{"id":26,"text":4377,"url":26,"identifiers":4378},"10.1037\u002Fe725622011-001",{"doi":4377},{"id":26,"text":4380,"url":26,"identifiers":4381},"Dwyer LL, 2014, Differences in Adult Day Services Center Participant Characteristics by Center Ownership: United States, 2012, NCHS Data Brief, 164, 1",{},{"id":26,"text":4383,"url":26,"identifiers":4384},"Dwyer LL, 2014, Differences in Adult Day Services Center Characteristics by Center Ownership: United States, 2012, NCHS Data Brief, 165, 1",{},{"id":26,"text":4386,"url":26,"identifiers":4387},"Mollica R, 2012, Assisted living and residential care in the states in 2010",{},{"id":26,"text":4389,"url":26,"identifiers":4390},"Sengupta M, 2015, Variation in Residential Care Community Resident Characteristics, by Size of Commnity: United States, 2014, NCHS Data Brief, 223, 1",{},{"id":26,"text":4392,"url":26,"identifiers":4393},"Caffrey C, 2015, Variation in Operating Characteristics of Residential Care Communities by Size of Community: United States, 2014, NCHS Data Brief, 222, 1",{},{"id":26,"text":4395,"url":26,"identifiers":4396},"American Health Care Association.LTC Stats: Nursing Facility Operational Characteristics Report.Table 5: Nursing Facility Beds in Dedicated Special Care Units; September2014.",{},{"id":26,"text":4398,"url":26,"identifiers":4399},"American Health Care Association.LTC Stats: Nursing Facility Operational Characteristics Report.Table 5: Nursing Facility Beds in Dedicated Special Care Units; June2013.",{},{"id":26,"text":4401,"url":26,"identifiers":4402},"10.1111\u002Fj.1532-5415.2012.03905.x",{"doi":4401},{"id":26,"text":4404,"url":26,"identifiers":4405},"10.1056\u002FNEJMsa1100347",{"doi":4404},{"id":26,"text":4407,"url":26,"identifiers":4408},"10.1089\u002Fjpm.2008.0168",{"doi":4407},{"id":26,"text":4410,"url":26,"identifiers":4411},"10.1377\u002Fhlthaff.2013.1248",{"doi":4410},{"id":26,"text":4413,"url":26,"identifiers":4414},"10.1001\u002Fjama.2012.207624",{"doi":4413},{"id":26,"text":4416,"url":26,"identifiers":4417},"10.1056\u002FNEJMsa1408705",{"doi":4416},{"id":26,"text":4419,"url":26,"identifiers":4420},"Eiken S, 2015, Medicaid expenditures for long‐term services and supports (LTSS) in FY 2013: Home and community‐based services were a majority of LTSS spending",{},{"id":26,"text":4422,"url":26,"identifiers":4423},"MetLife Mature Market Institute, 2012, Market Survey of Long‐Term Care Costs: The 2012 MetLife Market Survey of Nursing Home, Assisted Living, Adult Day Services, and Home Care Costs",{},{"id":26,"text":4425,"url":26,"identifiers":4426},"JacobsonG HuangJ NeumanT SmithKE.Income and Assets of Medicare Beneficiaries 2013‐2030.The Henry J. Kaiser Family Foundation Issue Brief. January2014.",{},{"id":26,"text":4428,"url":26,"identifiers":4429},"HHS Office of the Assistant Secretary for Planning and Evaluation Office of Disability Aging and Long‐Term Care Policy.Long‐Term Care Insurance.ASPE Research Brief. June2012.",{},{"id":26,"text":4431,"url":26,"identifiers":4432},"Stone RI, 2012, Public health for an aging society",{},{"id":26,"text":4434,"url":26,"identifiers":4435},"Kaiser Commission on Medicaid and the Uninsured, 2013, Long‐Term Services and Supports in the Financial Alignment Demonstrations for Dual Eligible Beneficiaries",{},{"id":26,"text":4437,"url":26,"identifiers":4438},"Moody's Investors Service.Special Comment: Long‐Term Care Insurance: Sector Profile; September 18 2012.",{},{"id":26,"text":4440,"url":26,"identifiers":4441},"Gilligan AM, 2013, Health disparities in cost of care in patients with Alzheimer's disease: An analysis across 4 state Medicaid populations, Am J Alzheimers Dis Other Demen, 28, 84, 10.1177\u002F1533317512467679",{"doi":4442},"10.1177\u002F1533317512467679",{"id":26,"text":4444,"url":26,"identifiers":4445},"10.1377\u002Fhlthaff.2013.1061",{"doi":4444},{"id":26,"text":4447,"url":26,"identifiers":4448},"10.1377\u002Fhlthaff.2013.1257",{"doi":4447},{"id":26,"text":4450,"url":26,"identifiers":4451},"U.S. Centers for Medicare and Medicaid Services.Hospice Center. Available at:http:\u002F\u002Fwww.cms.gov\u002FMedicare\u002FMedicare‐Fee‐for‐Service‐Payment\u002FHospice\u002FMedicare_Hospice_Data.html. Accessed November 6 2015.",{},{"id":26,"text":4453,"url":26,"identifiers":4454},"10.1016\u002Fj.jalz.2011.11.003",{"doi":4453},{"id":26,"text":4456,"url":26,"identifiers":4457},"U.S. Department of Agriculture.Household food security survey module: Six‐item short form. Available at:http:\u002F\u002Fwww.ers.usda.gov\u002Fdatafiles\u002FFood_Security_in_the_United_States\u002FFood_Security_Survey_Modules\u002Fshort2012.pdf. Accessed February 26 2016.",{},{"id":26,"text":4459,"url":26,"identifiers":4460},"American Association for Long‐Term Care Insurance.Long‐term care insurance facts‐statistics. Westlake Village CA. Available at:http:\u002F\u002Fwww.aaltci.org\u002Flong‐term‐careinsurance\u002Flearning‐center\u002Ffast‐facts.php. Accessed December 23 2015.",{},{"id":26,"text":3219,"url":26,"identifiers":4462},{"doi":3219},{"id":26,"text":4464,"url":26,"identifiers":4465},"National Alliance for Caregiving and AARP Caregiving in the U.S. November2009. Available at:http:\u002F\u002Fassets.aarp.org\u002Frgcenter\u002Fil\u002Fcaregiving_09_fr.pdf. Accessed November 6 2015.",{},{"id":26,"text":4467,"url":26,"identifiers":4468},"Amo PS, 1999, The economic value of informal caregiving, Health Aff, 18, 182, 10.1377\u002Fhlthaff.18.2.182",{"doi":4469},"10.1377\u002Fhlthaff.18.2.182",{"id":26,"text":4471,"url":26,"identifiers":4472},"U.S. Department of Labor Bureau of Labor Statistics.Employment Hours and Earnings from the Current Employment Statistics Survey. Series 10‐CEU 6562160008 Home Health Care Services (NAICS code 6216) Average Hourly Earnings July2015. Available at:www.bls.gov\u002Fces. Accessed December 28 2015.",{},{"id":26,"text":4474,"url":26,"identifiers":4475},"Albert SM, 2010, The MetLife Study of working caregivers and employer health care costs",{},{"id":26,"text":4477,"url":26,"identifiers":4478},"U.S. Centers for Medicare and Medicaid Services Center for Strategic Planning Health Expenditures by State of Residence 1991‐2009. Available at:www.cms.gov\u002FResearch‐Statistics‐Data‐and‐Systems\u002FStatistics‐Trends‐and‐Reports\u002FNationalHealthExpendData\u002FNationalHealthAccountsStateHealth%20AccountsResidence.html. Accessed January 22 2016.",{},{"id":26,"text":4480,"url":26,"identifiers":4481},"Shriver M, 2010, The Shriver Report: A Woman's Nation Takes on Alzheimer's",{},{"id":4483,"createTime":4484,"updateTime":4484,"relativeEntities":4485,"slug":4486,"properties":4487,"entityType":820,"verifyStatus":25,"verifyTime":4501,"verifyNote":821,"syncStatus":28,"languages":4502,"translateLanguages":26,"viewCount":36,"primaryUrl":4503,"fullTextUrl":26,"authors":4504,"publicationType":1884,"publisherRelationship":4652,"citationCount":4682,"citationInfo":4683,"publishDate":4695,"publishYear":4696,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":4697,"isForceReanalyzing":2624},"5bc5268b-31e8-4cd2-8602-b24d996afd70","2024-09-03T23:08:24.904+00:00",[],"The-global-prevalence-of-dementia-A-systematic-review-and-metaanalysis",{"mag":4488,"keywords":4490,"openalex":4491,"abstract":4493,"title":4495,"pm":4497,"doi":4499},{"VOID":4489},"2149450071",{},{"VOID":4492},"W2149450071",{"EN":4494},"\u003Cjats:sec>\u003Cjats:title>Background\u003C\u002Fjats:title>\u003Cjats:p>The evidence base on the prevalence of dementia is expanding rapidly, particularly in countries with low and middle incomes. A reappraisal of global prevalence and numbers is due, given the significant implications for social and public policy and planning.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Methods\u003C\u002Fjats:title>\u003Cjats:p>In this study we provide a systematic review of the global literature on the prevalence of dementia (1980–2009) and metaanalysis to estimate the prevalence and numbers of those affected, aged ≥60 years in 21 Global Burden of Disease regions.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C\u002Fjats:title>\u003Cjats:p>Age‐standardized prevalence for those aged ≥60 years varied in a narrow band, 5%–7% in most world regions, with a higher prevalence in Latin America (8.5%), and a distinctively lower prevalence in the four sub‐Saharan African regions (2%–4%). It was estimated that 35.6 million people lived with dementia worldwide in 2010, with numbers expected to almost double every 20 years, to 65.7 million in 2030 and 115.4 million in 2050. In 2010, 58% of all people with dementia lived in countries with low or middle incomes, with this proportion anticipated to rise to 63% in 2030 and 71% in 2050.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusion\u003C\u002Fjats:title>\u003Cjats:p>The detailed estimates in this study constitute the best current basis for policymaking, planning, and allocation of health and welfare resources in dementia care. The age‐specific prevalence of dementia varies little between world regions, and may converge further. Future projections of numbers of people with dementia may be modified substantially by preventive interventions (lowering incidence), improvements in treatment and care (prolonging survival), and disease‐modifying interventions (preventing or slowing progression). All countries need to commission nationally representative surveys that are repeated regularly to monitor trends.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":4496},"The global prevalence of dementia: A systematic review and metaanalysis",{"VOID":4498},"23305823",{"VOID":4500},"10.1016\u002Fj.jalz.2012.11.007","2024-09-03T23:08:24.903+00:00",[102],"https:\u002F\u002Falz-journals.onlinelibrary.wiley.com\u002Fdoi\u002F10.1016\u002Fj.jalz.2012.11.007",[4505,4525,4557,4574,4601,4629],{"id":4506,"sortIndex":115,"researcher":26,"roles":4507,"affiliations":4508,"properties":4520},"84ad772e-5431-40dc-b3cd-38b2e638b45e",[],[4509],{"id":4510,"sortIndex":36,"affiliation":4511,"properties":26},"ca6e2ec0-6281-4b6e-85a5-1d98dc66fb9c",{"id":4512,"createTime":4513,"updateTime":4514,"relativeEntities":4515,"slug":4516,"properties":4517,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"15812234-cb24-40fd-9294-fe51f717ba11","2023-12-28T00:00:31.446+00:00","2024-11-25T05:25:55.048+00:00",[],"Institute-of-Psychiatry-King-s-College-London-London-UK",{"title":4518},{"VI":4519},"Institute of Psychiatry, King's College London, London, 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The Special Report discusses the future challenges of meeting care demands for the growing number of people living with Alzheimer's dementia in the United States with a particular emphasis on primary care. By mid‐century, the number of Americans age 65 and older with Alzheimer's dementia may grow to 13.8 million. This represents a steep increase from the estimated 5.8 million Americans age 65 and older who have Alzheimer's dementia today. Official death certificates recorded 122,019 deaths from AD in 2018, the latest year for which data are available, making Alzheimer's the sixth leading cause of death in the United States and the fifth leading cause of death among Americans age 65 and older. Between 2000 and 2018, deaths resulting from stroke, HIV and heart disease decreased, whereas reported deaths from Alzheimer's increased 146.2%. In 2019, more than 16 million family members and other unpaid caregivers provided an estimated 18.6 billion hours of care to people with Alzheimer's or other dementias. This care is valued at nearly $244 billion, but its costs extend to family caregivers’ increased risk for emotional distress and negative mental and physical health outcomes. Average per‐person Medicare payments for services to beneficiaries age 65 and older with AD or other dementias are more than three times as great as payments for beneficiaries without these conditions, and Medicaid payments are more than 23 times as great. Total payments in 2020 for health care, long‐term care and hospice services for people age 65 and older with dementia are estimated to be $305 billion. As the population of Americans living with Alzheimer's dementia increases, the burden of caring for that population also increases. These challenges are exacerbated by a shortage of dementia care specialists, which places an increasing burden on primary care physicians (PCPs) to provide care for people living with dementia. Many PCPs feel underprepared and inadequately trained to handle dementia care responsibilities effectively. This report includes recommendations for maximizing quality care in the face of the shortage of specialists and training challenges in primary care.\u003C\u002Fjats:p>",{"EN":4901},"2020 Alzheimer's disease facts and figures",{"VOID":4903},"32157811",{"VOID":4905},"10.1002\u002Falz.12068",[102],"https:\u002F\u002Falz-journals.onlinelibrary.wiley.com\u002Fdoi\u002F10.1002\u002Falz.12068",[4909,4928,4943,4958,4973,4988],{"id":4910,"sortIndex":36,"researcher":26,"roles":4911,"affiliations":4912,"properties":4923},"4cdef357-9d3a-4cbe-8aea-42603be068ba",[],[4913],{"id":4914,"sortIndex":36,"affiliation":4915,"properties":26},"578e57f3-43c6-47b4-a8ed-427d152a1b8e",{"id":4916,"createTime":4917,"updateTime":4917,"relativeEntities":4918,"slug":4919,"properties":4920,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},"5f842579-919f-49b7-bf32-30499b6b6ad0","2024-10-08T13:03:15.205+00:00",[],"Families-Caring-for-an-Aging-America",{"title":4921},{"EN":4922},"Families Caring for an Aging America",{"openalex":4924,"title":4926},{"VOID":4925},"A5095659080",{"EN":4927},"In this phase",{"id":4929,"sortIndex":115,"researcher":26,"roles":4930,"affiliations":4931,"properties":4938},"0d408d5b-cc19-4778-82f4-f0cd491d868c",[],[4932],{"id":4933,"sortIndex":36,"affiliation":4934,"properties":26},"9bbf6087-b496-49e9-8e47-40cb59bad40e",{"id":4916,"createTime":4917,"updateTime":4917,"relativeEntities":4935,"slug":4919,"properties":4936,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4937},{"EN":4922},{"openalex":4939,"title":4941},{"VOID":4940},"A5095659081",{"EN":4942},"individuals have measurable brain changes that indicate the earliest signs of Alzheimer's disease",{"id":4944,"sortIndex":111,"researcher":26,"roles":4945,"affiliations":4946,"properties":4953},"e36b5dab-ea9b-4c55-ba66-3c2cf6945767",[],[4947],{"id":4948,"sortIndex":36,"affiliation":4949,"properties":26},"c57dc418-ae48-4bed-b345-706c65483d0b",{"id":4916,"createTime":4917,"updateTime":4917,"relativeEntities":4950,"slug":4919,"properties":4951,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4952},{"EN":4922},{"openalex":4954,"title":4956},{"VOID":4955},"A5095659084",{"EN":4957},"the brain compensates for them",{"id":4959,"sortIndex":162,"researcher":26,"roles":4960,"affiliations":4961,"properties":4968},"6a840037-5a26-44c2-a4ae-8d788cd27698",[],[4962],{"id":4963,"sortIndex":36,"affiliation":4964,"properties":26},"0e7ddc13-34c0-4b8f-b17e-347d962192d9",{"id":4916,"createTime":4917,"updateTime":4917,"relativeEntities":4965,"slug":4919,"properties":4966,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4967},{"EN":4922},{"openalex":4969,"title":4971},{"VOID":4970},"A5095659085",{"EN":4972},"enabling individuals to continue to function normally.",{"id":4974,"sortIndex":59,"researcher":26,"roles":4975,"affiliations":4976,"properties":4983},"96ed27c3-7aab-40a1-9a83-edf25389e28d",[],[4977],{"id":4978,"sortIndex":36,"affiliation":4979,"properties":26},"415abbc6-0745-42e1-8740-b017bc04e390",{"id":4916,"createTime":4917,"updateTime":4917,"relativeEntities":4980,"slug":4919,"properties":4981,"entityType":98,"verifyStatus":28,"verifyTime":26,"verifyNote":26,"syncStatus":28,"languages":26,"translateLanguages":26,"viewCount":36},[],{"title":4982},{"EN":4922},{"openalex":4984,"title":4986},{"VOID":4985},"A5095659083",{"EN":4987},"and decreased metabolism of glucose as shown on PET scans. 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Available at:https:\u002F\u002Fwww.alz.org\u002Fhelp-support\u002Fresources\u002Fpublications\u002Ftrajectory_report. Accessed December 4 2019.",{},{"id":26,"text":6592,"url":26,"identifiers":6593},"10.1515\u002Ffhep-2014-0013",{"doi":6592},{"id":26,"text":6595,"url":26,"identifiers":6596},"10.1016\u002Fj.jalz.2018.02.001",{"doi":6595},{"id":26,"text":6598,"url":26,"identifiers":6599},"LiuJL HlávkaJP HillestadR MattkeS. Assessing the preparedness of the U.S. health care system infrastructure for an Alzheimer's treatment. The RAND Corporation: Santa Monica CA. (2017) Available at:https:\u002F\u002Fwww.rand.org\u002Fpubs\u002Fresearch_reports\u002FRR2272.html. Accessed December 4 2019.",{},{"id":26,"text":3928,"url":26,"identifiers":6601},{"doi":3928},{"id":26,"text":3219,"url":26,"identifiers":6603},{"doi":3219},{"id":26,"text":6605,"url":26,"identifiers":6606},"National Alliance for Caregiving and AARP Caregiving in the U.S. November 2009. Available at:https:\u002F\u002Fwww.caregiving.org\u002Fpdf\u002Fresearch\u002FFINALRegularExSum50plus.pdf Accessed December 22 2019.",{},{"id":26,"text":4467,"url":26,"identifiers":6608},{"doi":4469},{"id":26,"text":6610,"url":26,"identifiers":6611},"U.S. Department of Labor Bureau of Labor Statistics. Employment Hours and Earnings from the Current Employment Statistics Survey. Series 10‐CEU 6562160008 Home Health Care Services (NAICS code 6216) Average Hourly Earnings July 2018. Available at:www.bls.gov\u002Fces\u002Fdata.htm. Accessed January 6 2020.",{},{"id":26,"text":6613,"url":26,"identifiers":6614},"10.1016\u002Fj.jalz.2019.07.005",{"doi":6613},{"id":26,"text":6616,"url":26,"identifiers":6617},"U.S. Department of Health and Human Services Health Resources and Services Administration National Center for Health Workforce Analysis. National and Regional Projections of Supply and Demand for Geriatricians: 2013‐2025. Available at:https:\u002F\u002Fbhw.hrsa.gov\u002Fsites\u002Fdefault\u002Ffiles\u002Fbhw\u002Fhealth-workforce-analysis\u002Fresearch\u002Fprojections\u002FGeriatricsReport51817.pdf. Accessed February 4 2020.",{},{"id":26,"text":6619,"url":26,"identifiers":6620},"Petriceks AH, 2018, Trends in geriatrics graduate medical education programs and positions, 2001 to 2018, Gerontol Geriatric Med, 4, 1, 10.1177\u002F2333721418777659",{"doi":6621},"10.1177\u002F2333721418777659",{"id":26,"text":6623,"url":26,"identifiers":6624},"10.1212\u002FWNL.0b013e318294b1cf",{"doi":6623},{"id":26,"text":6626,"url":26,"identifiers":6627},"10.14423\u002FSMJ.0000000000000196",{"doi":6626},{"id":26,"text":6629,"url":26,"identifiers":6630},"Scheckel CJ, 2019, Role of debt and loan forgiveness\u002Frepayment programs in osteopathic medical graduates' plans to enter primary care, J Am Osteopath Assoc, 119, 227",{},{"id":26,"text":6632,"url":26,"identifiers":6633},"Auerback DI, 2011, Registered nurse supply grows faster than projected amid surge in new entrants ages 23‐26, Health Aff, 30, 2286, 10.1377\u002Fhlthaff.2011.0588",{"doi":6634},"10.1377\u002Fhlthaff.2011.0588",{"id":26,"text":6636,"url":26,"identifiers":6637},"Meyers D, 2002, Title VII funding is associated with more family physicians and more physicians serving the underserved, Am Fam Physician, 66, 554",{},{"id":26,"text":6639,"url":26,"identifiers":6640},"Center for Medicare & Medicaid Services. Center for Medicare & Medicaid Innovation. The Graduate Nurse Education Demonstration Project: Final Evaluation Report. August 2019. Prepared by IMPAQ International Columbia Md. Available athttps:\u002F\u002Finnovation.cms.gov\u002FFiles\u002Freports\u002Fgne-final-eval-rpt.pdf. Accessed February 7 2020.",{},{"id":26,"text":6642,"url":26,"identifiers":6643},"10.1056\u002FNEJMoa1009370",{"doi":6642},{"id":26,"text":6645,"url":26,"identifiers":6646},"Paul M, 2019, Endo ECHO improves patient‐reported measures of access to care, health care quality, self‐care behaviors, and overall quality of life for patients with complex diabetes in medically underserved areas of New Mexico, J Endocr Soc, 3, 190, 10.1210\u002Fjs.2019-MON-190",{"doi":6647},"10.1210\u002Fjs.2019-MON-190",{"id":26,"text":6649,"url":26,"identifiers":6650},"10.1001\u002Fjamainternmed.2019.4101",{"doi":6649},{"id":6652,"createTime":6653,"updateTime":6653,"relativeEntities":6654,"slug":6655,"properties":6656,"entityType":820,"verifyStatus":28,"verifyTime":6666,"verifyNote":3344,"syncStatus":28,"languages":6667,"translateLanguages":26,"viewCount":36,"primaryUrl":6668,"fullTextUrl":26,"authors":6669,"publicationType":1884,"publisherRelationship":6676,"citationCount":6705,"citationInfo":6706,"publishDate":6713,"publishYear":6714,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":6715,"isForceReanalyzing":2624},"4275053e-7329-46cf-9fda-2363cd382140","2024-12-05T10:54:01.129+00:00",[],"2019-Alzheimer-s-disease-facts-and-figures",{"keywords":6657,"openalex":6658,"abstract":6660,"title":6662,"doi":6664},{},{"VOID":6659},"W4211139529",{"EN":6661},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:label\u002F>\u003Cjats:p>This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality and morbidity, use and costs of care, and the overall impact on caregivers and society. The Special Report examines the use of brief cognitive assessments by primary care physicians as a tool for improving early detection of dementia. An estimated 5.8 million Americans have Alzheimer's dementia. By mid‐century, the number of people living with Alzheimer's dementia in the United States may grow to 13.8 million, fueled in large part by the aging baby boom generation. In 2017, official death certificates recorded 121,404 deaths from AD, making AD the sixth leading cause of death in the United States and the fifth leading cause of death among Americans age ≥65 years. Between 2000 and 2017, deaths resulting from stroke, heart disease, and prostate cancer decreased, whereas reported deaths from AD increased 145%. In 2018, more than 16 million family members and other unpaid caregivers provided an estimated 18.5 billion hours of care to people with Alzheimer's or other dementias. This care is valued at nearly $234 billion, but its costs extend to family caregivers' increased risk for emotional distress and negative mental and physical health outcomes. Average per‐person Medicare payments for services to beneficiaries age ≥65 years with Alzheimer's or other dementias are more than three times as great as payments for beneficiaries without these conditions. Total payments in 2019 for health care, long‐term care and hospice services for people age ≥65 years with dementia are estimated to be $290 billion. Early detection of Alzheimer's offers numerous medical, emotional and financial benefits—benefits that accrue to affected individuals and their families as well as to society at large. Alzheimer's Association surveys regarding brief cognitive assessments for detection of dementia found that while a large majority of seniors and primary care physicians say the assessments are important, only half of seniors have received an assessment, and only 16 percent of seniors receive regular cognitive assessments. Many educational opportunities exist to facilitate increased use of brief cognitive assessments in the primary care setting.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":6663},"2019 Alzheimer's disease facts and 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Institutes of Health.National Institute on Aging.What happens to the Brain in Alzheimer's Disease? Available at:https:\u002F\u002Fwww.nia.nih.gov\u002Fhealth\u002Fwhat‐happens‐brainalzheimers‐diseaseAccessed September 14 2018",{},{"id":26,"text":2132,"url":26,"identifiers":6732},{"doi":2132},{"id":26,"text":1938,"url":26,"identifiers":6734},{"doi":1938},{"id":26,"text":1935,"url":26,"identifiers":6736},{"doi":1935},{"id":26,"text":1932,"url":26,"identifiers":6738},{"doi":1932},{"id":26,"text":1941,"url":26,"identifiers":6740},{"doi":1941},{"id":26,"text":2129,"url":26,"identifiers":6742},{"doi":2129},{"id":26,"text":2135,"url":26,"identifiers":6744},{"doi":2135},{"id":26,"text":3452,"url":26,"identifiers":6746},{"doi":3452},{"id":26,"text":3455,"url":26,"identifiers":6748},{"doi":3455},{"id":26,"text":3458,"url":26,"identifiers":6750},{"doi":3458},{"id":26,"text":5107,"url":26,"identifiers":6752},{"doi":5107},{"id":26,"text":3461,"url":26,"identifiers":6754},{"doi":3461},{"id":26,"text":3399,"url":26,"identifiers":6756},{"doi":3399},{"id":26,"text":3402,"url":26,"identifiers":6758},{"doi":3402},{"id":26,"text":3407,"url":26,"identifiers":6760},{"doi":3407},{"id":26,"text":2484,"url":26,"identifiers":6762},{"doi":2484},{"id":26,"text":2487,"url":26,"identifiers":6764},{"doi":2487},{"id":26,"text":3414,"url":26,"identifiers":6766},{"doi":3414},{"id":26,"text":3417,"url":26,"identifiers":6768},{"doi":3417},{"id":26,"text":5061,"url":26,"identifiers":6770},{"doi":5061},{"id":26,"text":5064,"url":26,"identifiers":6772},{"doi":5064},{"id":26,"text":6774,"url":26,"identifiers":6775},"De Reuck J, 2018, Aging and cerebrovascular lesions in pure and in mixed neurodegenerative and vascular dementia brains: A neuropathological study, Folia Neuropathol, 56, 81, 10.5114\u002Ffn.2018.76610",{"doi":5077},{"id":26,"text":5080,"url":26,"identifiers":6777},{"doi":5080},{"id":26,"text":6779,"url":26,"identifiers":6780},"National Institute on Aging.What are frontotemporal disorders? 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Families Caring for an Aging America",{},{"id":26,"text":6382,"url":26,"identifiers":7712},{},{"id":26,"text":7714,"url":26,"identifiers":7715},"The Lewin Group.Process Evaluation of the Older Americans Act Title IIIE‐National Family Caregiver Support Program: Final Report Available at:https:\u002F\u002Facl.gov\u002Fsites\u002Fdefault\u002Ffiles\u002Fprograms\u002F2017‐02\u002FNFCSP_Final_Report‐update.pdf2016Accessed December 18 2018",{},{"id":26,"text":4014,"url":26,"identifiers":7717},{"doi":4014},{"id":26,"text":7719,"url":26,"identifiers":7720},"Unpublished tabulations based on data from the Medicare Current Beneficiary Survey for 2011.Prepared under contract by Avalere Health March 2016",{},{"id":26,"text":4332,"url":26,"identifiers":7722},{"doi":4332},{"id":26,"text":6407,"url":26,"identifiers":7724},{"doi":6407},{"id":26,"text":4335,"url":26,"identifiers":7726},{"doi":4335},{"id":26,"text":6418,"url":26,"identifiers":7728},{"doi":6418},{"id":26,"text":4338,"url":26,"identifiers":7730},{"doi":4338},{"id":26,"text":7732,"url":26,"identifiers":7733},"Unpublished tabulations based on data from the National 5% Sample Medicare Fee‐for‐Service Beneficiaries for 2014.Prepared under contract by Avalere Health January 2016",{},{"id":26,"text":7735,"url":26,"identifiers":7736},"Bynum JPW, 2016, Our Parents, Ourselves: Health Care for an Aging Population. A Report of the Dartmouth Atlas Project",{},{"id":26,"text":4341,"url":26,"identifiers":7738},{"doi":4341},{"id":26,"text":6431,"url":26,"identifiers":7740},{"doi":6431},{"id":26,"text":6437,"url":26,"identifiers":7742},{"doi":6437},{"id":26,"text":7744,"url":26,"identifiers":7745},"U.S. Centers for Medicare & Medicaid Services.State Level Chronic Conditions Table: Prevalence Medicare Utilization and Spending Available at:https:\u002F\u002Fwww.cms.gov\u002FResearch‐Statistics‐Data‐and‐Systems\u002FStatistics‐Trends‐and‐Reports\u002FChronic‐Conditions\u002FCC_Main.html2015Accessed December 18 2018",{},{"id":26,"text":7747,"url":26,"identifiers":7748},"Medicare. 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Kaiser Family Foundation.Percent of Women who Report Having No Personal Doctor\u002FHealth Care Provider by Race\u002FEthnicity Available at:https:\u002F\u002Fwww.kff.org\u002Fdisparities‐policy\u002Fstate‐indicator\u002Fno‐personal‐doctor\u002F?currentTimeframe=0&sortModel=%7B%22colId%22:%22Location%22 %22sort%22:%22asc%22%7DAccessed January 22 2019",{},{"id":26,"text":7903,"url":26,"identifiers":7904},"Henry J. Kaiser Family Foundation.Percent of Men who Report Having No Personal Doctor\u002FHealth Care Provider by Race\u002FEthnicity Available at:https:\u002F\u002Fwww.kff.org\u002Fdisparities‐policy\u002Fstate‐indicator\u002Fpercent‐of‐men‐who‐report‐having‐no‐personal‐doctorhealth‐care‐provider‐by‐raceethnicity\u002FAccessed January 22 2019",{},{"id":26,"text":7906,"url":26,"identifiers":7907},"10.1093\u002Fgerona\u002Fglp188",{"doi":7906},{"id":26,"text":7909,"url":26,"identifiers":7910},"10.3399\u002Fbjgp16X686101",{"doi":7909},{"id":26,"text":7912,"url":26,"identifiers":7913},"10.1111\u002Fj.1365-2753.2009.01235.x",{"doi":7912},{"id":26,"text":7915,"url":26,"identifiers":7916},"Urban Institute Health Policy Center Health Reform Monitoring Survey.Do Patients Trust Their Providers? Available at:http:\u002F\u002Fhrms.urban.org\u002Fbriefs\u002Fdo‐patients‐trust‐their‐providers.html2017Accessed January 22 2019",{},{"id":26,"text":7918,"url":26,"identifiers":7919},"Urban Institute Health Policy Center Health Reform Monitoring Survey.Patients Feel Comfortable Talking to Their Providers about Sensitive Issues But Providers Don't Often Ask Available at:http:\u002F\u002Fhrms.urban.org\u002Fbriefs\u002Fpatients‐comfortable‐talking‐providers‐sensitive‐issues.html2017Accessed January 22 2019",{},{"id":26,"text":7921,"url":26,"identifiers":7922},"American Society on Aging.MetLife Foundation Harris Interactive Inc. Attitudes and Awareness of Brain Health Poll Available at:http:\u002F\u002Fwww.paulnussbaum.com\u002Fmetlifedoc.pdf2006Accessed January 22 2019",{},{"id":26,"text":7924,"url":26,"identifiers":7925},"John A. Hartford Foundation.How Does It Feel?: The Older Adult Health Care Experience Available at:https:\u002F\u002Fwww.johnahartford.org\u002Fevents\u002Fview\u002Fjohn‐a.‐hartford‐foundation‐public‐poll‐how‐does‐it‐feel‐the‐older‐adult‐he2012Accessed January 22 2019",{},{"id":26,"text":7927,"url":26,"identifiers":7928},"U.S. Centers for Medicare & Medicaid Services Enterprise Portal.Beneficiaries Utilizing Free Preventive Services by State Available at:https:\u002F\u002Fdownloads.cms.gov\u002Ffiles\u002FBeneficiaries%20Utilizing%20Free%20Preventive%20Services%20by%20State%20YTD%202016.pdf2016Accessed January 22 2019",{},{"id":26,"text":7930,"url":26,"identifiers":7931},"U.S. Centers for Medicare & Medicaid Services Enterprise Portal.Beneficiaries Utilizing Free Preventive Services by State Available at:https:\u002F\u002Fdownloads.cms.gov\u002Ffiles\u002FBeneficiaries%20Utilizing%20Free%20Preventive%20Services%20by%20State%20YTD%202015.pdf2015Accessed January 22 2019",{},{"id":26,"text":7933,"url":26,"identifiers":7934},"10.1001\u002Fjama.2017.4342",{"doi":7933},{"id":26,"text":7936,"url":26,"identifiers":7937},"U.S. Centers for Medicare & Medicaid Services.Medicare Learning Network.Annual Wellness Visit Available at:https:\u002F\u002Fwww.cms.gov\u002FOutreach‐and‐Education\u002FMedicare‐Learning‐Network‐MLN\u002FMLNProducts\u002FDownloads\u002FAWV_Chart_ICN905706.pdf2018Accessed January 22 2019",{},{"id":26,"text":7939,"url":26,"identifiers":7940},"National Institute on Aging.Alzheimer's and Dementia Resources for Professionals. Available at:https:\u002F\u002Fwww.nia.nih.gov\u002Fhealth\u002Falzheimers‐dementia‐resources‐for‐professionals. Accessed January 31 2019",{},{"id":26,"text":7942,"url":26,"identifiers":7943},"Alzheimer's Association.Cognitive Assessment Toolkit. Available at:https:\u002F\u002Fwww.alz.org\u002Fmedia\u002FDocuments\u002Fcognitive‐assessment‐toolkit.pdf. Accessed January 22 2019",{},{"id":26,"text":7945,"url":26,"identifiers":7946},"Gerontological Society of America.KAER Toolkit: 4‐Step Process to Detecting Cognitive Impairment and Earlier Diagnosis of Dementia Available at:https:\u002F\u002Fwww.geron.org\u002Fprograms‐services\u002Falliances‐and‐multi‐stakeholder‐collaborations\u002Fcognitive‐impairment‐detection‐and‐earlier‐diagnosis2015Accessed January 22 2019",{},{"id":26,"text":7948,"url":26,"identifiers":7949},"American Academy of Family Physicians.Cognitive Care Kit. Available at:https:\u002F\u002Fwww.aafp.org\u002Fpatient‐care\u002Fpublic‐health\u002Fcognitive‐care.html. Accessed January 22 2018",{},{"id":26,"text":7951,"url":26,"identifiers":7952},"Act on Alzheimer's®.Provider Practice Tools. Available at:http:\u002F\u002Factonalz.org\u002Fprovider‐practice‐tools. Accessed January 31 2019",{},{"id":26,"text":7954,"url":26,"identifiers":7955},"10.1177\u002F0733464811401354",{"doi":7954},{"id":26,"text":7957,"url":26,"identifiers":7958},"Creavin ST, 2016, Mini‐Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations, Cochrane Database Syst Rev, 1",{},{"id":26,"text":7960,"url":26,"identifiers":7961},"Ranson JM, 2018, Predictors of dementia misclassification when using brief cognitive assessments, Neurol Clin Pract",{},{"id":26,"text":7963,"url":26,"identifiers":7964},"Warren‐Findlow J, 2010, Primary care providers' sources and preferences for cognitive health information in the United States, Health Promot Int, 25, 464, 10.1093\u002Fheapro\u002Fdaq043",{"doi":7965},"10.1093\u002Fheapro\u002Fdaq043",{"id":26,"text":7967,"url":26,"identifiers":7968},"10.1097\u002FWAD.0000000000000039",{"doi":7967},{"id":26,"text":7970,"url":26,"identifiers":7971},"10.2217\u002Fnmt.15.43",{"doi":7970},{"id":26,"text":7973,"url":26,"identifiers":7974},"10.2217\u002Fnmt-2016-0004",{"doi":7973},{"id":26,"text":7976,"url":26,"identifiers":7977},"10.3122\u002Fjabfm.2010.04.090225",{"doi":7976},{"id":26,"text":7979,"url":26,"identifiers":7980},"10.2105\u002FAJPH.93.4.635",{"doi":7979},{"id":26,"text":7982,"url":26,"identifiers":7983},"Yarnall KS, 2009, Family physicians as team leaders: “Time” to share the care, Prev Chronic Dis, 6, A59",{},{"id":26,"text":7985,"url":26,"identifiers":7986},"10.1002\u002Fgps.1524",{"doi":7985},{"id":26,"text":7988,"url":26,"identifiers":7989},"10.1016\u002Fj.dadm.2015.01.002",{"doi":7988},{"id":26,"text":7991,"url":26,"identifiers":7992},"10.1111\u002Fj.1525-1497.2005.0126.x",{"doi":7991},{"id":26,"text":7994,"url":26,"identifiers":7995},"10.1016\u002Fj.jalz.2012.09.011",{"doi":7994},{"id":26,"text":7997,"url":26,"identifiers":7998},"Alzheimer's Association and the Centers for Disease Control and Prevention.Healthy Brain Initiative: State and Local Public Health Partnerships to Address Dementia: The 2018‐2023 Road Map Available at:https:\u002F\u002Fwww.cdc.gov\u002Faging\u002Fpdf\u002F2018‐2023‐Road‐Map‐508.pdfAccessed January 21 2019",{},{"id":26,"text":8000,"url":26,"identifiers":8001},"10.1016\u002Fj.dadm.2015.06.009",{"doi":8000},{"id":26,"text":8003,"url":26,"identifiers":8004},"10.1186\u002F1471-2318-13-134",{"doi":8003},{"id":26,"text":8006,"url":26,"identifiers":8007},"Pond D, 2018, Effectiveness of a peer‐mediated educational intervention in improving general practitioner diagnostic assessment and management of dementia: A cluster randomised controlled trial, BMJ Open, 8, e021125, 10.1136\u002Fbmjopen-2017-021125",{"doi":8008},"10.1136\u002Fbmjopen-2017-021125",{"id":26,"text":8010,"url":26,"identifiers":8011},"10.1016\u002Fj.jalz.2017.08.003",{"doi":8010},{"id":26,"text":5117,"url":26,"identifiers":8013},{"doi":5117},{"id":26,"text":3928,"url":26,"identifiers":8015},{"doi":3928},{"id":26,"text":3219,"url":26,"identifiers":8017},{"doi":3219},{"id":26,"text":8019,"url":26,"identifiers":8020},"National Alliance for Caregiving and AARP.Caregiving in the U.S. November2009 Available at:https:\u002F\u002Fwww.caregiving.org\u002Fpdf\u002Fresearch\u002FFINALRegularExSum50plus.pdfAccessed January 22 2019",{},{"id":26,"text":4467,"url":26,"identifiers":8022},{"doi":4469},{"id":26,"text":8024,"url":26,"identifiers":8025},"U.S. Department of Labor Bureau of Labor Statistics.Employment Hours and Earnings from the Current Employment Statistics Survey.Series 10‐CEU 6562160008 Home Health Care Services (NAICS code 6216) Average Hourly Earnings July2018 Available at:www.bls.gov\u002Fces\u002Fdata.htmAccessed January 3 2019",{},{"id":26,"text":4474,"url":26,"identifiers":8027},{},{"id":26,"text":8029,"url":26,"identifiers":8030},"U.S. Centers for Medicare & Medicaid Services.Health Expenditures by State of Residence 1991‐2014 Available at:https:\u002F\u002Fwww.cms.gov\u002FResearch‐Statistics‐Data‐and‐Systems\u002FStatistics‐Trends‐and‐Reports\u002FNationalHealthExpendData\u002FNationalHealthAccountsStateHealthAccountsResidence.htmlAccessed December 18 2018",{},{"id":26,"text":8032,"url":26,"identifiers":8033},"Shriver M, 2010, The Shriver Report: A Woman's Nation Takes on Alzheimer's",{},{"id":8035,"createTime":8036,"updateTime":8036,"relativeEntities":8037,"slug":8038,"properties":8039,"entityType":820,"verifyStatus":25,"verifyTime":8036,"verifyNote":821,"syncStatus":28,"languages":8054,"translateLanguages":26,"viewCount":36,"primaryUrl":8055,"fullTextUrl":26,"authors":8056,"publicationType":1884,"publisherRelationship":8885,"citationCount":8915,"citationInfo":8916,"publishDate":8924,"publishYear":8925,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":8926,"isForceReanalyzing":2624},"911307c5-7898-44ac-bb69-7e3386bff88e","2024-08-31T09:18:05.098+00:00",[],"A-conceptual-framework-for-research-on-subjective-cognitive-decline-in-preclinical-Alzheimer-s-disease",{"mag":8040,"keywords":8042,"pmc":8043,"openalex":8045,"abstract":8047,"title":8049,"pm":8051,"doi":8053},{"VOID":8041},"2048505725",{},{"VOID":8044},"4317324",{"VOID":8046},"W2048505725",{"EN":8048},"\u003Cjats:title>Abstract\u003C\u002Fjats:title>\u003Cjats:sec>\u003Cjats:label\u002F>\u003Cjats:p>There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer's disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD‐I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre‐mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. 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The Special Report discusses consumers' and primary care physicians' perspectives on awareness, diagnosis and treatment of mild cognitive impairment (MCI), including MCI due to Alzheimer's disease. An estimated 6.5 million Americans age 65 and older are living with Alzheimer's dementia today. This number could grow to 13.8 million by 2060 barring the development of medical breakthroughs to prevent, slow or cure AD. Official death certificates recorded 121,499 deaths from AD in 2019, the latest year for which data are available. Alzheimer's disease was officially listed as the sixth‐leading cause of death in the United States in 2019 and the seventh‐leading cause of death in 2020 and 2021, when COVID‐19 entered the ranks of the top ten causes of death. Alzheimer's remains the fifth‐leading cause of death among Americans age 65 and older. Between 2000 and 2019, deaths from stroke, heart disease and HIV decreased, whereas reported deaths from AD increased more than 145%. More than 11 million family members and other unpaid caregivers provided an estimated 16 billion hours of care to people with Alzheimer's or other dementias in 2021. These figures reflect a decline in the number of caregivers compared with a decade earlier, as well as an increase in the amount of care provided by each remaining caregiver. Unpaid dementia caregiving was valued at $271.6 billion in 2021. Its costs, however, extend to family caregivers’ increased risk for emotional distress and negative mental and physical health outcomes — costs that have been aggravated by COVID‐19. Members of the dementia care workforce have also been affected by COVID‐19. As essential care workers, some have opted to change jobs to protect their own health and the health of their families. However, this occurs at a time when more members of the dementia care workforce are needed. Average per‐person Medicare payments for services to beneficiaries age 65 and older with AD or other dementias are almost three times as great as payments for beneficiaries without these conditions, and Medicaid payments are more than 22 times as great. Total payments in 2022 for health care, long‐term care and hospice services for people age 65 and older with dementia are estimated to be $321 billion. A recent survey commissioned by the Alzheimer's Association revealed several barriers to consumers’ understanding of MCI. The survey showed low awareness of MCI among Americans, a reluctance among Americans to see their doctor after noticing MCI symptoms, and persistent challenges for primary care physicians in diagnosing MCI. 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Accessed February 3 2022.",{},{"id":26,"text":10992,"url":26,"identifiers":10993},"Sabbagh MN, 2020, Early detection of mild cognitive impairment (MCI) in primary care, J Prev Alzheimers Dis, 7, 165",{},{"id":26,"text":7994,"url":26,"identifiers":10995},{"doi":7994},{"id":26,"text":10997,"url":26,"identifiers":10998},"10.1002\u002Falz.057470",{"doi":10997},{"id":26,"text":11000,"url":26,"identifiers":11001},"10.1097\u002FWAD.0000000000000310",{"doi":11000},{"id":26,"text":11003,"url":26,"identifiers":11004},"10.1001\u002Fjamanetworkopen.2021.25725",{"doi":11003},{"id":26,"text":11006,"url":26,"identifiers":11007},"ACT on Alzheimer's. Screening and Diagnosing Diverse Populations. Available at:https:\u002F\u002Fwww.actonalz.org\u002Fscreening‐diverse‐populations. Accessed February 3 2022.",{},{"id":26,"text":11009,"url":26,"identifiers":11010},"10.1016\u002Fj.dadm.2018.09.003",{"doi":11009},{"id":26,"text":11012,"url":26,"identifiers":11013},"10.3233\u002FJAD-201370",{"doi":11012},{"id":26,"text":11015,"url":26,"identifiers":11016},"Department of Health & Human Services Centers for Medicare & Medicaid Services. LTSS Research: Cognitive Assessment Tools. December 15 2017. Available at:https:\u002F\u002Fwww.cms.gov\u002FOutreach‐and‐Education\u002FAmerican‐Indian‐Alaska‐Native\u002FAIAN\u002FLTSS‐TA‐Center\u002Fpdf\u002FBest‐Practices‐Dementia‐Cognitive‐Assessment‐Tools.pdf. Accessed February 3 2022.",{},{"id":26,"text":11018,"url":26,"identifiers":11019},"Alzheimer's Association. 2017 Alzheimer's disease facts and figures. Available at:https:\u002F\u002Fwww.alz.org\u002Fmedia\u002Fimages\u002F2017‐facts‐and‐figures.pdf. Accessed February 3 2022.",{},{"id":26,"text":11021,"url":26,"identifiers":11022},"Alzheimer's Association. 2021 Alzheimer's Association Research Fellowship (AARF): Innovative approaches to diagnosis of AD for non‐specialty practice. Available at:https:\u002F\u002Fwww.alz.org\u002Fresearch\u002Ffor_researchers\u002Fgrants\u002Ffunded‐studies‐details?FundedStudyID=2504. Accessed February 3 2022.",{},{"id":26,"text":11024,"url":26,"identifiers":11025},"Clinicaltrials.gov. Discovery of novel biomarkers that will lead to the early detection of Alzheimer's disease (BVB). Available at:https:\u002F\u002Fclinicaltrials.gov\u002Fct2\u002Fshow\u002FNCT03136679. Accessed February 3 2022.",{},{"id":26,"text":11027,"url":26,"identifiers":11028},"Clinicaltrials.gov. Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study. Available at:https:\u002F\u002Fclinicaltrials.gov\u002Fct2\u002Fshow\u002FNCT02612376. 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Accessed February 3 2022.",{},{"id":26,"text":11040,"url":26,"identifiers":11041},"Oxford AE, 2020, Clinical trials in Alzheimer's disease: A hurdle in the path of remedy, Int J Alzheimers Dis, 2020, 5380346",{},{"id":26,"text":11043,"url":26,"identifiers":11044},"10.1377\u002Fhlthaff.2013.1314",{"doi":11043},{"id":26,"text":11046,"url":26,"identifiers":11047},"10.1097\u002FWAD.0b013e3181aba927",{"doi":11046},{"id":26,"text":11049,"url":26,"identifiers":11050},"National Institute on Aging. Together We Make the Difference: National Strategy for Recruitment and Participation in Alzheimer's and Related Dementias Clinical Research. October 2018. Available at:https:\u002F\u002Fwww.nia.nih.gov\u002Fsites\u002Fdefault\u002Ffiles\u002F2018‐10\u002Falzheimers‐disease‐recruitment‐strategy‐final.pdf. Accessed February 3. 2022.",{},{"id":26,"text":3219,"url":26,"identifiers":11052},{"doi":3219},{"id":26,"text":11054,"url":26,"identifiers":11055},"U.S. Department of Labor. Changes in Basic Minimum Wages in Non‐Farm Employment Under State Law: Selected Years 1968 to 2021. Available at:https:\u002F\u002Fwww.dol.gov\u002Fagencies\u002Fwhd\u002Fstate\u002Fminimum‐wage\u002Fhistory. 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In the absence of a disease‐modifying treatment or cure, reducing the risk of developing dementia takes on added importance. In 2014, the World Dementia Council (WDC) requested the Alzheimer's Association evaluate and report on the state of the evidence on modifiable risk factors for cognitive decline and dementia. This report is a summary of the Association's evaluation, which was presented at the October 2014 WDC meeting. The Association believes there is sufficient evidence to support the link between several modifiable risk factors and a reduced risk for cognitive decline, and sufficient evidence to suggest that some modifiable risk factors may be associated with reduced risk of dementia. Specifically, the Association believes there is sufficiently strong evidence, from a population‐based perspective, to conclude that regular physical activity and management of cardiovascular risk factors (diabetes, obesity, smoking, and hypertension) reduce the risk of cognitive decline and may reduce the risk of dementia. 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CL, 2014, Temporal trends in dementia incidence in the Framingham Study, Alzheimers Dement, 10, P296",{},{"id":26,"text":3904,"url":26,"identifiers":11608},{"doi":3904},{"id":26,"text":3907,"url":26,"identifiers":11610},{"doi":3907},{"id":26,"text":3913,"url":26,"identifiers":11612},{"doi":3913},{"id":26,"text":11614,"url":26,"identifiers":11615},"10.1016\u002Fj.jalz.2014.02.006",{"doi":11614},{"id":26,"text":11617,"url":26,"identifiers":11618},"10.1371\u002Fjournal.pone.0081877",{"doi":11617},{"id":26,"text":5759,"url":26,"identifiers":11620},{"doi":5759},{"id":26,"text":11622,"url":26,"identifiers":11623},"Middleton LE, 2010, Targets for the prevention of dementia, J Alzheimers Dis, 20, 915, 10.3233\u002FJAD-2010-091657",{"doi":11624},"10.3233\u002FJAD-2010-091657",{"id":26,"text":11626,"url":26,"identifiers":11627},"10.1212\u002FWNL.0000000000001537",{"doi":11626},{"id":26,"text":11629,"url":26,"identifiers":11630},"10.1186\u002Falzrt104",{"doi":11629},{"id":26,"text":11632,"url":26,"identifiers":11633},"Monsuez JJ, 2011, Cardiovascular prevention of cognitive decline, Cardiol Res Pract, 2011, 250970, 10.4061\u002F2011\u002F250970",{"doi":11634},"10.4061\u002F2011\u002F250970",{"id":26,"text":11636,"url":26,"identifiers":11637},"NganduT LehtisaloJ SolomonA LevalahtiE AhtiluotoRA BackmanL et al.A 2‐year multidomain intervention of diet exercise cognitive training and vascular risk monitoring versus control to prevent cognitive decline in at‐risk elderly people (FINGER): a randomised controlled trial.Lancet2015https:\u002F\u002Fdoi.org\u002F10.1016\u002FS0140–6736(15)60461‐5 Epub ahead of print",{},{"id":26,"text":3528,"url":26,"identifiers":11639},{},{"id":26,"text":11641,"url":26,"identifiers":11642},"World Dementia Council.WDC Dementia Risk Reduction Statement. Available at:https:\u002F\u002Fs3‐eu‐west‐1.amazonaws.com\u002Fmedia.dh.gov.uk\u002Fnetwork\u002F353\u002Ffiles\u002F2015\u002F01\u002FWDC‐supportive‐statement‐on‐risk‐reduction‐FINAL‐FOR‐PUBLICATION‐BRANDED‐150128‐LM.pdf. Accessed on April 7  2015.",{},{"id":11644,"createTime":11645,"updateTime":11645,"relativeEntities":11646,"slug":11647,"properties":11648,"entityType":820,"verifyStatus":28,"verifyTime":11645,"verifyNote":3344,"syncStatus":28,"languages":11658,"translateLanguages":26,"viewCount":36,"primaryUrl":11659,"fullTextUrl":26,"authors":11660,"publicationType":1884,"publisherRelationship":11661,"citationCount":11690,"citationInfo":11691,"publishDate":11695,"publishYear":11696,"citationAnalyzeStatus":28,"lastCitationAnalyze":26,"indexDatabases":26,"openAccess":26,"references":11697,"isForceReanalyzing":2624},"fb74e351-8b08-4e66-9b73-4a521a9c2bec","2024-10-01T07:40:39.763+00:00",[],"2017-Alzheimer-s-disease-facts-and-figures",{"keywords":11649,"openalex":11650,"abstract":11652,"title":11654,"doi":11656},{},{"VOID":11651},"W4211028926",{"EN":11653},"\u003Cjats:sec>\u003Cjats:label \u002F>\u003Cjats:p>This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, costs of care, and the overall impact on caregivers and society. The \u003Cjats:ext-link xmlns:xlink=\"http:\u002F\u002Fwww.w3.org\u002F1999\u002Fxlink\" xlink:href=\"http:\u002F\u002F10.1016\u002Fj.jalz.2017.02.006\">Special Report\u003C\u002Fjats:ext-link> examines how the use of biomarkers may influence the AD diagnostic process and estimates of prevalence and incidence of the disease. An estimated 5.5 million Americans have Alzheimer's dementia. By mid‐century, the number of people living with Alzheimer's dementia in the United States is projected to grow to 13.8 million, fueled in large part by the aging baby boom generation. Today, someone in the country develops Alzheimer's dementia every 66 seconds. By 2050, one new case of Alzheimer's dementia is expected to develop every 33 seconds, resulting in nearly 1 million new cases per year. In 2014, official death certificates recorded 93,541 deaths from AD, making AD the sixth leading cause of death in the United States and the fifth leading cause of death in Americans age ≥65 years. Between 2000 and 2014, deaths resulting from stroke, heart disease, and prostate cancer decreased 21%, 14%, and 9%, respectively, whereas deaths from AD increased 89%. The actual number of deaths to which AD contributes is likely much larger than the number of deaths from AD recorded on death certificates. In 2017, an estimated 700,000 Americans age ≥65 years will have AD when they die, and many of them will die because of the complications caused by AD. In 2016, more than 15 million family members and other unpaid caregivers provided an estimated 18.2 billion hours of care to people with Alzheimer's or other dementias. This care is valued at more than $230 billion. Average per‐person Medicare payments for services to beneficiaries age ≥65 years with Alzheimer's or other dementias are more than three times as great as payments for beneficiaries without these conditions, and Medicaid payments are more than 23 times as great. Total payments in 2017 for health care, long‐term care, and hospice services for people age ≥65 years with dementia are estimated to be $259 billion. In recent years, efforts to develop and validate AD biomarkers, including those detectable with brain imaging and in the blood and cerebrospinal fluid, have intensified. Such efforts could transform the practice of diagnosing AD from one that focuses on cognitive and functional symptoms to one that incorporates biomarkers. This new approach could promote diagnosis at an earlier stage of disease and lead to a more accurate understanding of AD prevalence and incidence.\u003C\u002Fjats:p>\u003C\u002Fjats:sec>",{"EN":11655},"2017 Alzheimer's disease facts and 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