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Res., 26, 313, 10.1017\u002FS0016672300016116\nBeck, 1978, Das Y-Chromosom von Drosophila hydei: Lokalisation und Isolation der Gene mittels Y-Fragmenten, Arch. Genet., 51, 109\nBeermann, 1952, Chromomerenkonstanz und spezifische Modifikationen der Chromosomenstruktur in der Entwicklung und Organdifferenzierung von Chironomus tentans, Chromosoma, 5, 139, 10.1007\u002FBF01271486\nBerendes, 1963, The salivary gland chromosomes of Drosophila hydei Sturtevant, Chromosoma, 14, 195, 10.1007\u002FBF00336760\nBode, 1977, On the competition between protamines and histones: Studies directed towards the understanding of spermiogenesis, Eur. J. Biochem., 72, 393, 10.1111\u002Fj.1432-1033.1977.tb11264.x\nBoender, 1983\nBonaccorsi, 1981, Cytological dissection of sex chromosome heterochromatin of Drosophila hydei, Chromosoma, 84, 391, 10.1007\u002FBF00286028\nBonaccorsi, S., Hennig, W., and Hackstein, J. H. P. (1984). Cytogenetic dissection of the Y chromosome of Drosophila hydei. Submitted.\nBridges, 1916, Non-disjunction as proof of the chromosome theory of heredity, Genetics, 1, 1, 10.1093\u002Fgenetics\u002F1.1.1\nBrosseau, 1960, Genetic analysis of the male fertility factors on the Y chromosome of Drosphila melanogaster, Genetics, 44, 257, 10.1093\u002Fgenetics\u002F45.3.257\nCallan, 1982, Lampbrush chromosomes, Proc. Soc. London, B Ser., 214, 417, 10.1098\u002Frspb.1982.0020\nCooper, 1950, Normal spermatogenesis in Drosophila, 1\nDavidson, 1976\nde Loos, 1984, Lampbrush chromosome loop-specificity of transcript morphology in spermatocyte nuclei of Drosophila hydei, EMBO J., 3, 10.1002\u002Fj.1460-2075.1984.tb02218.x\nDemerec, 1950\nDiaz, 1981, Transcripts from both strands of a satellite DNA occur on lampbrush chromosome loops of the newt Notophthalamus, Cell, 24, 649, 10.1016\u002F0092-8674(81)90091-X\nDowsett, 1983, Closely related species of Drosophila can contain different libraries of middle repetitive DNA sequences, Chromosoma, 88, 104, 10.1007\u002FBF00327329\nFowler, 1973, In vitro cell differentiation in the testes of Drosophila hydei, Cell Differ., 2, 33, 10.1016\u002F0045-6039(73)90004-3\nFranke, 1976, Absence of nucleosomes in transcriptionally active chromatin, Cytobios, 13, 401\nGatti, 1983, Cytological and genetic analysis of the Y chromosome of Drosophila melanogaster. I. Organization of the fertility factors, Chromosoma, 88, 349, 10.1007\u002FBF00285858\nGlätzer, 1975, Visualization of gene transcription in spermatocytes of Drosophila hydei, Chromosoma, 53, 371, 10.1007\u002FBF00294084\nGlätzer, 1981, Morphological aspects of the genetic activity in primary spermatocyte nuclei of Drosophila hydei, Biol. Cell., 41, 165\nGrell, 1969, Sterility, lethality and segregation rations in XYY males of Drosophila melanogaster, Genetics, 61, s23\nGrond, 1983, Visualization of a lampbrush loop-forming fertility gene in Drosophila hydei, Chromosoma, 88, 50, 10.1007\u002FBF00329503\nGrond, 1984, Ultrastructure of the Y chromosomal lampbrush loops in primary spermatocytes of Drosophila hydei, Chromosoma, 89, 85, 10.1007\u002FBF00292891\nGrond, C. J., Kühtreiber, W., and Hennig, W. (1984b). Spermiogenesis in Drosophila hydei. Submitted for publication.\nHackstein, 1982, Mutants of Drosophila hydei, Drosophila Inf. Serv., 58, 195\nHackstein, 1982, Genetic fine structure of the Y chromosome of Drosophila hydei, Genetics, 101, 257, 10.1093\u002Fgenetics\u002F101.2.257\nHanna, 1982, Evidence against a (2)n synchronous increase of spermatogonia to produce spermatocytes in Drosophila hydei, Gamete Res., 6, 365, 10.1002\u002Fmrd.1120060408\nHardy, 1981, Analysis of spermatogenesis in Drosophila melanogaster bearing deletions for Y-chromosome fertility genes, Chromosoma, 83, 593, 10.1007\u002FBF00328522\nHauschteck-Jungen, 1982, Defective histone transition during spermiogenesis in heterozygous segregation distorter males of Drosophila melanogaster, Genetics, 101, 57, 10.1093\u002Fgenetics\u002F101.1.57\nHennig, 1972\nHennig, 1978, Vergleichend-zytologische und genetische Untersuchungen am Genom der Fruchtfliegen-Arten Drosophila hydei, D. neohydei und D. eohydei, Entomol. Ger., 4, 211\nHennig, 1982, “Hybrid” X-Y translocation chromosomes of Drosophila hydei and D. neohydei, Chromosoma, 86, 491, 10.1007\u002FBF00330123\nHennig, 1967, Untersuchungen zur Struktur und Funktion des Lampenbürsten-Y-Chromosoms in der Spermatogenese von Drosophila, Chromosoma, 22, 294, 10.1007\u002FBF00319879\nHennig, 1968, Ribonucleic acid synthesis of the Y-chromosome of Drosophila hydei, J. Mol. Biol., 38, 227, 10.1016\u002F0022-2836(68)90408-7\nHennig, 1972, Highly repetitive DNA sequences in the genome of Drosophila hydei. I. Preferential localization in the X chromosome heterochromatin, J. Mol. Biol., 71, 407, 10.1016\u002F0022-2836(72)90359-2\nHennig, 1972, Highly repetitive DNA sequences in the genome of Drosophila hydei. II. Occurrence in polytene tissues, J. Mol. Biol., 71, 419, 10.1016\u002F0022-2836(72)90360-9\nHennig, 1973, Molecular hybridization of DNA and RNA in situ, Int. Rev. 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Ser., 51, 127\nHennig, 1975, The location of the nucleolus organizer regions in Drosophila hydei, Chromosoma, 51, 57, 10.1007\u002FBF00285808\nHennig, 1982, Nucleolus organizer regions in Drosophila species of the repleta group, Chromosoma, 87, 279, 10.1007\u002FBF00327630\nHennig, 1983, Molecular cloning of microdissected lampbrush loop DNA sequences of Drosophila hydei, EMBO J., 2, 1736, 10.1002\u002Fj.1460-2075.1983.tb01651.x\nHess, 1964, Strukturdifferenzierungen im Y-Chromosom von Drosophila hydei und ihre Beziehungen zu Genaktivitäten. I. Mutanten der Funktionsstrukturen, Verh. Dtsch. Zool. Ges., 156\nHess, 1965, Struktur-Differenzierungen im Y-Chromosom von Drosophila hydei und ihre Beziehungen zu Gen-Aktivitäten. III. 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White variegation., Genetics., 57, 751, 10.1093\u002Fgenetics\u002F57.4.751\nStern, 1955, Studies on the position effect of the cubitus interruptus locus of Drosophila melanogaster., Genetics., 40, 343, 10.1093\u002Fgenetics\u002F40.3.343\nWolfe, 1967, Mapping the hemoglobin locus in mice transmitting the flecked translocation., Genetics., 55, 213, 10.1093\u002Fgenetics\u002F55.2.213",{"EN":201},"Position-Effect Variegation",{"VOID":203},"10.1016\u002Fs0065-2660(08)60426-5","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0065266008604265",[206],{"id":207,"sortIndex":41,"researcher":18,"roles":208,"affiliations":209,"properties":218},"61a8b4e7-fa33-4540-ab81-e0fd06ba9065",[79],[210],{"id":18,"sortIndex":41,"affiliation":211,"properties":18},{"id":212,"createTime":213,"updateTime":213,"relativeEntities":214,"slug":18,"properties":215,"entityType":89,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":41},"67971251-f074-41cc-9872-c12211b64ea6","2024-02-06T06:39:44.288+00:00",[],{"title":216},{"VI":217},"Department of Biology, University of Chicago, Chicago, Illinois",{"title":219},{"VI":220},"William K. Baker",{"url":204,"publisher":222,"properties":241},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":223,"slug":10,"properties":224,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":227,"manageAffiliations":228,"indexDatabases":229,"url":18,"thumbnailPath":18,"statistic":236,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"issn":225,"title":226},{"VOID":13},{"EN":15},[],[],[230],{"id":24,"indexDatabase":231,"url":37,"indexYears":38,"academicFieldIds":18,"indexDatabaseRanking":39},{"id":26,"createTime":27,"updateTime":28,"relativeEntities":232,"label":233,"description":234,"key":34,"publicationTags":235,"standard":18},[],{"EN":31,"VI":31},{"EN":31,"VI":33},[36],{"impactFactor":41,"impactFactorByYear":237,"i10Index":41,"i10IndexLast5Year":41,"totalPublication":43,"totalPublicationByYear":238,"totalCitation":41,"totalCitationByYear":239,"totalCitationPerPublication":41,"totalCitationPerPublicationByYear":240,"hindexLast5Year":41,"hindex":41},{},{"1947":45,"1948":46,"1951":45,"1953":45,"1955":45,"1958":45,"1962":45,"1964":45,"1968":46,"1970":46,"1971":46,"1976":46,"1982":45,"1984":46,"1985":45,"1987":45,"1988":45,"1990":19,"1991":19,"1994":45,"1995":45,"1996":45,"1997":45,"1998":45,"2001":47,"2005":48,"2006":45,"2008":49,"2009":45,"2010":50,"2011":51,"2012":45,"2014":46,"2016":46,"2017":45,"2018":45,"2019":45,"2020":46,"2021":19},{},{},{"volume":242,"pages":244},{"VOID":243},"14",{"VOID":245},"133-169","1968-01-01",1968,{"id":249,"createTime":250,"updateTime":251,"relativeEntities":252,"slug":253,"properties":254,"entityType":71,"verifyStatus":72,"verifyTime":261,"verifyNote":73,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":41,"primaryUrl":262,"fullTextUrl":18,"authors":263,"publicationType":93,"publisherRelationship":291,"citationCount":18,"citationInfo":18,"publishDate":316,"publishYear":317,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":121},"0f639025-9cb9-4b57-987d-ab54ad33ab4b","2023-12-07T16:35:57.682+00:00","2025-01-09T23:29:05.451+00:00",[],"The-Molecular-Genetics-Of-Crown-Gall-Tumorigenesis",{"references":255,"title":257,"doi":259},{"VOID":256},"Ackermann, 1977, Pflanzen aus Agrobacterium rhizogenes-tumoren an Nicotiana tabacum., Plant Sci. 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Bacteriol., 92, 746, 10.1128\u002FJB.92.3.746-750.1966",{"EN":258},"The Molecular Genetics Of Crown Gall Tumorigenesis",{"VOID":260},"10.1016\u002Fs0065-2660(08)60041-3","2025-01-09T23:29:05.450+00:00","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0065266008600413",[264,279],{"id":265,"sortIndex":45,"researcher":18,"roles":266,"affiliations":267,"properties":276},"896ed08e-b78f-4b17-8c8b-a2367b05e303",[79],[268],{"id":18,"sortIndex":41,"affiliation":269,"properties":18},{"id":270,"createTime":271,"updateTime":271,"relativeEntities":272,"slug":18,"properties":273,"entityType":89,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":41},"fc8359a4-4092-4bec-95ae-2c6a3a2a1e15","2023-12-07T16:35:57.699+00:00",[],{"title":274},{"VI":275},"Laboratory of Biochemistry, University of Leiden, Leiden, The Netherlands",{"title":277},{"VI":278},"R.A. Schilperoort",{"id":280,"sortIndex":41,"researcher":18,"roles":281,"affiliations":282,"properties":288},"6949f624-1554-4d48-9955-ba69a4bca519",[79],[283],{"id":18,"sortIndex":41,"affiliation":284,"properties":18},{"id":270,"createTime":271,"updateTime":271,"relativeEntities":285,"slug":18,"properties":286,"entityType":89,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":41},[],{"title":287},{"VI":275},{"title":289},{"VI":290},"P.J.J. Hooykaas",{"url":262,"publisher":292,"properties":311},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":293,"slug":10,"properties":294,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":297,"manageAffiliations":298,"indexDatabases":299,"url":18,"thumbnailPath":18,"statistic":306,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"issn":295,"title":296},{"VOID":13},{"EN":15},[],[],[300],{"id":24,"indexDatabase":301,"url":37,"indexYears":38,"academicFieldIds":18,"indexDatabaseRanking":39},{"id":26,"createTime":27,"updateTime":28,"relativeEntities":302,"label":303,"description":304,"key":34,"publicationTags":305,"standard":18},[],{"EN":31,"VI":31},{"EN":31,"VI":33},[36],{"impactFactor":41,"impactFactorByYear":307,"i10Index":41,"i10IndexLast5Year":41,"totalPublication":43,"totalPublicationByYear":308,"totalCitation":41,"totalCitationByYear":309,"totalCitationPerPublication":41,"totalCitationPerPublicationByYear":310,"hindexLast5Year":41,"hindex":41},{},{"1947":45,"1948":46,"1951":45,"1953":45,"1955":45,"1958":45,"1962":45,"1964":45,"1968":46,"1970":46,"1971":46,"1976":46,"1982":45,"1984":46,"1985":45,"1987":45,"1988":45,"1990":19,"1991":19,"1994":45,"1995":45,"1996":45,"1997":45,"1998":45,"2001":47,"2005":48,"2006":45,"2008":49,"2009":45,"2010":50,"2011":51,"2012":45,"2014":46,"2016":46,"2017":45,"2018":45,"2019":45,"2020":46,"2021":19},{},{},{"volume":312,"pages":314},{"VOID":313},"22",{"VOID":315},"209-283","1984-01-01",1984,{"id":319,"createTime":320,"updateTime":321,"relativeEntities":322,"slug":323,"properties":324,"entityType":71,"verifyStatus":17,"verifyTime":321,"verifyNote":333,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":41,"primaryUrl":334,"fullTextUrl":18,"authors":335,"publicationType":93,"publisherRelationship":357,"citationCount":18,"citationInfo":18,"publishDate":382,"publishYear":383,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":121},"67439606-bb56-4b12-9288-90050385e2b6","2023-11-14T23:40:24.691+00:00","2024-12-30T22:56:25.657+00:00",[],"Chapter-4-Genetics-and-Molecular-Pathophysiology-of-Nav1-7-Related-Pain-Syndromes",{"pii":325,"abstract":327,"title":329,"doi":331},{"VOID":326},"S0065266008010043",{"EN":328},"SCN9A, the gene which encodes voltage‐gated sodium channel Nav1.7, is located on human chromosome 2 within a cluster of other members of this gene family. Nav1.7 is present at high levels in most peripheral nociceptive neurons in dorsal root ganglion (DRG) and in sympathetic neurons. In addition to its focal tissue‐specific expression, Nav1.7 is distinguished by its ability to amplify small depolarizations, thus acting as a threshold channel and modulating excitability. Dominantly inherited gain‐of‐function mutations in SCN9A have been linked to two familial painful disorders: inherited erythromelalgia (IEM) and paroxysmal extreme pain disorder (PEPD). One set of mutations leads to severe episodes of pain in the feet and hands in patients with IEM, and a different set of mutations causes pain in a perirectal, periocular, and mandibular distribution in patients with PEPD. These mutations allow mutant channels to activate in response to weaker stimuli, or to remain open longer in response to stimulation. The introduction of mutant channels into DRG neurons alters electrogenesis and renders these primary sensory neurons hyperexcitable. Mutant Nav1.7 channels lower the threshold for single action potentials and increase the number of action potentials that neurons fire in response to suprathreshold stiumli. In contrast, recessively inherited loss‐of‐function mutations in SCN9A, which cause a loss of function of Nav1.7 in patients, lead to indifference to pain with sparing of motor and cognitive abilities. The central role of Nav1.7 in these disorders, and the apparently limited consequences of loss of this channel in humans make it an attractive target for treatment of pain.",{"EN":330},"Chapter 4 Genetics and Molecular Pathophysiology of Nav1.7‐Related Pain Syndromes",{"VOID":332},"10.1016\u002FS0065-2660(08)01004-3","Author affiliation is blank","https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0065266008010043",[336,343,350],{"id":337,"sortIndex":41,"researcher":18,"roles":338,"affiliations":339,"properties":340},"c05a1da2-5713-4c5c-a857-e149cda0d498",[79],[],{"title":341},{"VI":342},"Yang  Yong",{"id":344,"sortIndex":41,"researcher":18,"roles":345,"affiliations":346,"properties":347},"cf134c82-5ae0-4cde-aa3b-74ed4471e071",[79],[],{"title":348},{"VI":349},"Dib‐Hajj  Sulayman D.",{"id":351,"sortIndex":41,"researcher":18,"roles":352,"affiliations":353,"properties":354},"b022522a-3572-4928-8be8-6c175192daee",[79],[],{"title":355},{"VI":356},"Waxman  Stephen G.",{"url":334,"publisher":358,"properties":377},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":359,"slug":10,"properties":360,"entityType":16,"verifyStatus":17,"verifyTime":18,"verifyNote":18,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":19,"subjectFields":363,"manageAffiliations":364,"indexDatabases":365,"url":18,"thumbnailPath":18,"statistic":372,"gsStatistic":18,"type":18,"analyzePriority":18},[],{"issn":361,"title":362},{"VOID":13},{"EN":15},[],[],[366],{"id":24,"indexDatabase":367,"url":37,"indexYears":38,"academicFieldIds":18,"indexDatabaseRanking":39},{"id":26,"createTime":27,"updateTime":28,"relativeEntities":368,"label":369,"description":370,"key":34,"publicationTags":371,"standard":18},[],{"EN":31,"VI":31},{"EN":31,"VI":33},[36],{"impactFactor":41,"impactFactorByYear":373,"i10Index":41,"i10IndexLast5Year":41,"totalPublication":43,"totalPublicationByYear":374,"totalCitation":41,"totalCitationByYear":375,"totalCitationPerPublication":41,"totalCitationPerPublicationByYear":376,"hindexLast5Year":41,"hindex":41},{},{"1947":45,"1948":46,"1951":45,"1953":45,"1955":45,"1958":45,"1962":45,"1964":45,"1968":46,"1970":46,"1971":46,"1976":46,"1982":45,"1984":46,"1985":45,"1987":45,"1988":45,"1990":19,"1991":19,"1994":45,"1995":45,"1996":45,"1997":45,"1998":45,"2001":47,"2005":48,"2006":45,"2008":49,"2009":45,"2010":50,"2011":51,"2012":45,"2014":46,"2016":46,"2017":45,"2018":45,"2019":45,"2020":46,"2021":19},{},{},{"volume":378,"pages":380},{"VOID":379},"63",{"VOID":381},"85","2008-12-31",2008,{"id":385,"createTime":386,"updateTime":387,"relativeEntities":388,"slug":389,"properties":390,"entityType":71,"verifyStatus":72,"verifyTime":387,"verifyNote":73,"syncStatus":17,"languages":18,"translateLanguages":18,"viewCount":41,"primaryUrl":397,"fullTextUrl":18,"authors":398,"publicationType":93,"publisherRelationship":416,"citationCount":18,"citationInfo":18,"publishDate":441,"publishYear":442,"citationAnalyzeStatus":17,"lastCitationAnalyze":18,"indexDatabases":18,"openAccess":18,"references":18,"isForceReanalyzing":121},"f1b1bbdd-2a17-4ecf-ac46-4560b7f6adea","2023-12-06T00:05:38.603+00:00","2025-02-11T22:39:43.288+00:00",[],"Drosophila-Gene-Enzyme-Systems",{"references":391,"title":393,"doi":395},{"VOID":392},"Ayala, 1972, Enzyme variability in the Drosophila willistoni group. 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