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Khái niệm về pro-thuốc cho phép các nhà nghiên cứu tìm kiếm các phương pháp mới để có được các loại thuốc hiệu quả với các đặc tính dược động học và dược lý học được cải thiện. Thiosulfinates, được hình thành enzymatic từ sulfoxide của amino acid khi nghiền nát tế bào của thực vật thuộc chi Allium, được biết đến như những hợp chất chống vi sinh. Tính không ổn định và độ phản ứng cao của thiosulfinates làm phức tạp việc sử dụng chúng như các hợp chất chống vi sinh riêng lẻ. Chúng tôi đề xuất một cặp hoạt tính dược lý bổ sung: một pro-thuốc sulfoxide của amino acid và methionine-lyase phụ thuộc vào vitamin B6, điều này chuyển hóa nó trong cơ thể bệnh nhân. Enzyme xúc tác cho các phản ứng loại bỏ - và - của sulfoxide, tương tự của L-methionine và L-cysteine, dẫn đến hình thành thiosulfinates. Trong công trình này, chúng tôi đã sao chép gen enzyme từ Clostridium sporogenes. Các dạng ion và tautomeric của aldimine nội bộ đã được xác định nhờ phân tích lognormal deconvolution quang phổ holoenzyme và các thông số xúc tác của enzyme tái tổ hợp trong các phản ứng loại bỏ - và - của các amino acid, và một số sulfoxide của amino acid đã được thu được. Lần đầu tiên, khả năng sử dụng enzyme để chuyển đổi hiệu quả sulfoxides đã được thiết lập và hoạt tính kháng vi sinh của thiosulfinates chống lại vi khuẩn Gram âm và Gram dương trong tình huống thực tế đã được chứng minh.\u003C\u002Fjats:p>","\u003Cjats:p>The problem of resistance to antibiotics requires the development of new classes of broad-spectrum antimicrobial drugs. The concept of pro-drugs allows researchers to look for new approaches to obtain effective drugs with improved pharmacokinetic and pharmacodynamic properties. Thiosulfinates, formed enzymatically from amino acid sulfoxides upon crushing cells of genus Allium plants, are known as antimicrobial compounds. The instability and high reactivity of thiosulfinates complicate their use as individual antimicrobial compounds. We propose a pharmacologically complementary pair: an amino acid sulfoxide pro-drug and vitamin B6 - dependent methionine -lyase, which metabolizes it in the patients body. The enzyme catalyzes the - and -elimination reactions of sulfoxides, analogues of L-methionine and L-cysteine, which leads to the formation of thiosulfinates. In the present work, we cloned the enzyme gene from Clostridium sporogenes. Ionic and tautomeric forms of the internal aldimine were determined by lognormal deconvolution of the holoenzyme spectrum and the catalytic parameters of the recombinant enzyme in the - and -elimination reactions of amino acids, and some sulfoxides of amino acids were obtained. For the first time, the possibility of usage of the enzyme for effective conversion of sulfoxides was established and the antimicrobial activity of thiosulfinates against Gram-negative and Gram-positive bacteria in situ was shown.\u003C\u002Fjats:p>",{"VI":377,"EN":378},"Các Sulfoxides, Tương Tự của L-Methionine và L-Cysteine Làm Pro-Thuốc Chống Lại Các Vi Khuẩn Gram-Dương và Gram Âm","Sulfoxides, Analogues of L-Methionine and L-Cysteine As Pro-Drugs against Gram-Positive and Gram-Negative Bacteria",{"VOID":380},"26798500",{"VOID":382},"10.32607\u002F20758251-2015-7-4-128-135","2024-10-02T07:39:04.237+00:00",[146],[148],"http:\u002F\u002Factanaturae.ru\u002F2075-8251\u002Farticle\u002Fview\u002F10486",[388,410,432,450,467,482,499,517,534,550],{"id":389,"sortIndex":266,"researcher":23,"roles":390,"affiliations":391,"properties":403},"3a0a38a9-37fd-47ee-a063-a0896f4c23af",[],[392],{"id":393,"sortIndex":24,"affiliation":394,"properties":23},"37d62ab6-22f0-46fd-be3d-00ea9d3f0a12",{"id":395,"createTime":396,"updateTime":397,"relativeEntities":398,"slug":399,"properties":400,"entityType":68,"verifyStatus":22,"verifyTime":23,"verifyNote":23,"syncStatus":22,"languages":23,"translateLanguages":23,"viewCount":24},"f179fea7-d447-46a1-b3ff-d5ef913cad45","2024-04-16T02:04:03.255+00:00","2024-10-02T07:39:04.299+00:00",[],"State-Research-Institute-of-Genetics-and-Selection-of-Industrial-Microorganisms",{"title":401},{"EN":402},"State Research Institute of Genetics and Selection of Industrial Microorganisms",{"openalex":404,"orcid":406,"title":408},{"VOID":405},"A5061552232",{"VOID":407},"https:\u002F\u002Forcid.org\u002F0000-0003-3995-6205",{"EN":409},"G. 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Enzyme từ C. sporogenes được đặc trưng bởi hiệu suất xúc tác cao nhất trong phản ứng - loại bỏ L-methionine. Đã được chứng minh rằng enzyme từ ba nguồn này tồn tại dưới dạng tetramer. Mảnh poly-histidine đầu N của ba enzyme tái tổ hợp ảnh hưởng đến hoạt tính xúc tác của chúng và thúc đẩy quá trình ngưng tụ các monomer để tạo thành các dạng dimer trong điều kiện biến tính. Tính độc tế bào của methionine γ-lyase từ C. sporogenes và C. tetani so với Citrobacter freundii đã được đánh giá sử dụng các dòng tế bào khối u K562, PC-3, LnCap, MCF7, SKOV-3 và L5178y. K562 (IC50=0.4-1.3 U\u002Fml), PC-3 (IC50=0.1-0.4 U\u002Fml) và MCF7 (IC50=0.04-3.2 U\u002Fml) hóa ra là những dòng tế bào nhạy cảm nhất.\u003C\u002Fjats:p>","\u003Cjats:p>The steady-state kinetic parameters of pyridoxal 5-phosphate-dependent recombinant methionine -lyase from three pathogenic bacteria, Clostridium tetani, Clostridium sporogenes, and Porphyromonas gingivalis, were determined in - and -elimination reactions. The enzyme from C. sporogenes is characterized by the highest catalytic efficiency in the -elimination reaction of L-methionine. It was demonstrated that the enzyme from these three sources exists as a tetramer. The N-terminal poly-histidine fragment of three recombinant enzymes influences their catalytic activity and facilitates the aggregation of monomers to yield dimeric forms under denaturing conditions. The cytotoxicity of methionine -lyase from C. sporogenes and C. tetani in comparison with Citrobacter freundii was evaluated using K562, PC-3, LnCap, MCF7, SKOV-3, and L5178y tumor cell lines. 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Sự thất bại trong việc hoạt động của các kênh Kv dẫn đến các rối loạn di truyền nghiêm trọng và sự phát triển của các khối u, bao gồm cả các khối u ác tính. Việc hiểu các cơ chế nền tảng cho sự hoạt động của các kênh Kv là yếu tố then chốt trong việc xác định nguyên nhân của các bệnh liên quan đến sự đột biến trong các kênh này, cũng như trong việc tìm kiếm các loại thuốc mới. Cơ chế kích hoạt các kênh là một chủ đề đang được tranh luận, và cho đến nay vẫn chưa đạt được sự đồng thuận về vấn đề này. Bài đánh giá này thảo luận về các giai đoạn chính trong việc nghiên cứu các cơ chế hoạt động của các kênh Kv và mô tả các mô hình cơ bản của sự kích hoạt của chúng đã được biết đến cho đến nay.","\u003Cjats:p>Voltage-gated potassium ion channels (Kv) play an important role in a variety of cellular processes, including the functioning of excitable cells, regulation of apoptosis, cell growth and differentiation, the release of neurotransmitters and hormones, maintenance of cardiac activity, etc. Failure in the functioning of Kv channels leads to severe genetic disorders and the development of tumors, including malignant ones. Understanding the mechanisms underlying Kv channels functioning is a key factor in determining the cause of the diseases associated with mutations in the channels, and in the search for new drugs. The mechanism of activation of the channels is a topic of ongoing debate, and a consensus on the issue has not yet been reached. 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Nguyên nhân là do nghiên cứu chủ yếu tập trung vào việc nghiên cứu các protein sốc nhiệt và các yếu tố liên quan (HSPs và HSFs), cũng như vai trò của chúng trong việc điều chỉnh quá trình phiên mã, cân bằng protein, v.v. Gần đây, đã có một số tiến bộ trong việc nghiên cứu ảnh hưởng của stress nhiệt đối với tính toàn vẹn của DNA. Trong bài tổng quan này, chúng tôi tóm tắt và thảo luận về các cơ chế đã được biết đến và có khả năng xảy ra trong sự hình thành các tổn thương DNA do stress nhiệt gây ra.\u003C\u002Fjats:p>","\u003Cjats:p>Although the heat-stress response has been extensively studied for decades, very little is known about its effects on nucleic acids and nucleic acid-associated processes. This is due to the fact that the research has focused on the study of heat shock proteins and factors (HSPs and HSFs), their involvement in the regulation of transcription, protein homeostasis, etc. Recently, there has been some progress in the study of heat stress effects on DNA integrity. In this review, we summarize and discuss well-known and potential mechanisms of formation of various heat stress-induced DNA damage.\u003C\u002Fjats:p>",{"VI":981,"EN":982},"Tổn thương DNA do Stress Nhiệt","Heat Stress-Induced DNA Damage",{"VOID":984},"27437141",{"VOID":986},"10.32607\u002F20758251-2016-8-2-75-78","2024-09-26T21:25:04.000+00:00",[146],[148],"http:\u002F\u002Factanaturae.ru\u002F2075-8251\u002Farticle\u002Fview\u002F10442",[992,1009,1026,1041],{"id":993,"sortIndex":174,"researcher":23,"roles":994,"affiliations":995,"properties":1002},"1e80d857-a3c4-443e-9f86-929a21e500a7",[],[996],{"id":997,"sortIndex":24,"affiliation":998,"properties":23},"60337900-7fc5-4290-829a-2203a413eb2f",{"id":784,"createTime":785,"updateTime":786,"relativeEntities":999,"slug":788,"properties":1000,"entityType":68,"verifyStatus":22,"verifyTime":23,"verifyNote":23,"syncStatus":22,"languages":23,"translateLanguages":23,"viewCount":24},[],{"title":1001},{"EN":791},{"openalex":1003,"orcid":1005,"title":1007},{"VOID":1004},"A5015460943",{"VOID":1006},"https:\u002F\u002Forcid.org\u002F0000-0002-8859-5306",{"EN":1008},"Artem V. Luzhin",{"id":1010,"sortIndex":24,"researcher":23,"roles":1011,"affiliations":1012,"properties":1019},"8cb06c3e-7d97-49a2-b6f4-f54f19ac4e0f",[],[1013],{"id":1014,"sortIndex":24,"affiliation":1015,"properties":23},"b4496b69-e02f-46c0-b4b0-1b6a69879c95",{"id":784,"createTime":785,"updateTime":786,"relativeEntities":1016,"slug":788,"properties":1017,"entityType":68,"verifyStatus":22,"verifyTime":23,"verifyNote":23,"syncStatus":22,"languages":23,"translateLanguages":23,"viewCount":24},[],{"title":1018},{"EN":791},{"openalex":1020,"orcid":1022,"title":1024},{"VOID":1021},"A5023735846",{"VOID":1023},"https:\u002F\u002Forcid.org\u002F0000-0002-7507-7307",{"EN":1025},"Omar L. Kantidze",{"id":1027,"sortIndex":217,"researcher":23,"roles":1028,"affiliations":1029,"properties":1036},"a84aa7c1-365a-4264-ba07-5dfd766015d8",[],[1030],{"id":1031,"sortIndex":24,"affiliation":1032,"properties":23},"291d4bf5-94f7-4c70-8d75-8b09c8b15c2b",{"id":784,"createTime":785,"updateTime":786,"relativeEntities":1033,"slug":788,"properties":1034,"entityType":68,"verifyStatus":22,"verifyTime":23,"verifyNote":23,"syncStatus":22,"languages":23,"translateLanguages":23,"viewCount":24},[],{"title":1035},{"EN":791},{"openalex":1037,"title":1039},{"VOID":1038},"A5078953870",{"EN":1040},"Artem K. 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Razin",{"url":23,"publisher":1070,"properties":1095},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1071,"slug":10,"properties":1072,"entityType":21,"verifyStatus":22,"verifyTime":23,"verifyNote":23,"syncStatus":22,"languages":23,"translateLanguages":23,"viewCount":24,"subjectFields":1078,"manageAffiliations":1079,"indexDatabases":1080,"url":112,"thumbnailPath":23,"statistic":23,"gsStatistic":23,"type":23,"analyzePriority":23},[],{"country":1073,"issn":1074,"introduce":1075,"eissn":1076,"title":1077},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":15},{"EN":20},[],[],[1081,1088],{"id":72,"indexDatabase":1082,"url":87,"indexYears":23,"academicFieldIds":1087,"indexDatabaseRanking":23},{"id":74,"createTime":75,"updateTime":76,"relativeEntities":1083,"label":1084,"description":1085,"key":83,"publicationTags":1086,"standard":23},[],{"EN":79,"VI":79},{"VI":81,"EN":82},[85,86],[89],{"id":91,"indexDatabase":1089,"url":104,"indexYears":105,"academicFieldIds":1094,"indexDatabaseRanking":111},{"id":93,"createTime":94,"updateTime":95,"relativeEntities":1090,"label":1091,"description":1092,"key":101,"publicationTags":1093,"standard":23},[],{"EN":98,"VI":98},{"EN":98,"VI":100},[103],[107,108,109,110],{"volume":1096,"pages":1097,"issue":1099},{"VOID":115},{"VOID":1098},"75-78",{"VOID":1100},"2",105,{"total":1101,"publishYear":23,"statisticByYear":1103},{"2017":194,"2018":536,"2019":501,"2020":1104,"2021":1105,"2022":1106,"2023":1107,"2024":1108},18,17,22,19,11,[],{"id":1111,"createTime":1112,"updateTime":1113,"relativeEntities":1114,"slug":1115,"properties":1116,"entityType":142,"verifyStatus":143,"verifyTime":1112,"verifyNote":144,"syncStatus":22,"languages":1135,"translateLanguages":1136,"viewCount":24,"primaryUrl":1137,"fullTextUrl":23,"authors":1138,"publicationType":233,"publisherRelationship":1225,"citationCount":1257,"citationInfo":1258,"publishDate":23,"publishYear":23,"citationAnalyzeStatus":22,"lastCitationAnalyze":23,"indexDatabases":23,"openAccess":23,"references":1263,"isForceReanalyzing":270},"cf3e3a18-0daa-4a06-adc8-3d961250de43","2024-10-07T22:22:25.232+00:00","2025-01-01T11:28:51.947+00:00",[],"Monitoring-of-the-Zeta-Potential-of-Human-Cells-upon-Reduction-in-Their-Viability-and-Interaction-with-Polymers",{"mag":1117,"keywords":1119,"pmc":1121,"openalex":1123,"abstract":1125,"title":1128,"pm":1131,"doi":1133},{"VOID":1118},"16501288",{"VI":1120},"tiềm năng zeta, tán xạ ánh sáng động, tế bào HeLa, phosphatidylserine, apoptosis, polyme màng",{"VOID":1122},"3372997",{"VOID":1124},"W16501288",{"VI":1126,"EN":1127},"\u003Cjats:p>Kỹ thuật tán xạ ánh sáng động (DLS) đã được áp dụng để đánh giá tiềm năng zeta của màng plasma của tế bào người. Tại pH 7.4, tiềm năng zeta của các loại tế bào khác nhau cho thấy sự biến thiên trên một khoảng rộng và tương ứng là -19.4 ± 0.8 mV đối với tế bào HeLa và -31.8 ± 1.1 mV đối với hồng cầu. Sự khác biệt này có thể được quy cho sự khác biệt trong thành phần sinh hóa của màng plasma tế bào. Kết quả của việc làm nóng tế bào HeLa, tiềm năng zeta đã dịch chuyển về phía các điện thế âm hơn 4.2 mV. Một sự gia tăng tiềm năng zeta tương quan với sự gia tăng hàm lượng phosphatidylserine trên bề mặt tế bào, được coi là một dấu hiệu sớm của quá trình apoptosis. Kỹ thuật DLS cũng đã được sử dụng để nghiên cứu các tương tác giữa các tế bào và các polyme có tính màng, chẳng hạn như polycation và Pluronic L121 không ion.","\u003Cjats:p>The dynamic light scattering (DLS) technique was applied in order to assess the zeta potential of the plasma membrane of human cells. At pH 7.4, the cell zeta potential for different types of cells showed variations over a wide range and was equal to -19.4  0.8 mV for HeLa cells and -31.8  1.1 mV for erythrocytes. The difference could presumably be attributed to the differences in the biochemical composition of the cell plasma membrane. As a result of the heating of HeLa cells, the zeta potential shifted towards more negative voltages by 4.2 mV. An increase in the zeta potential correlated with an increase in the content of phosphatidylserine on the cell surface, which is considered to be an early marker of apoptosis. The DLS technique was also used to study the interactions between the cells and membranotropic polymers, such as polycations and nonionogenic Pluronic L121.\u003C\u002Fjats:p>",{"VI":1129,"EN":1130},"Giám sát Tiềm năng Zeta của Tế bào Người Khi Giảm Độ Việc Sống và Tương Tác Với Polyme","Monitoring of the Zeta Potential of Human Cells upon Reduction in Their Viability and Interaction with Polymers",{"VOID":1132},"22708066",{"VOID":1134},"10.32607\u002F20758251-2012-4-1-78-81",[146],[148],"http:\u002F\u002Factanaturae.ru\u002F2075-8251\u002Farticle\u002Fview\u002F10637",[1139,1161,1176,1193,1210],{"id":1140,"sortIndex":217,"researcher":23,"roles":1141,"affiliations":1142,"properties":1154},"f273e5d4-9cee-493d-a514-6c7efe55ae06",[],[1143],{"id":1144,"sortIndex":24,"affiliation":1145,"properties":23},"a37a4d50-9103-4420-9359-c609919c1173",{"id":1146,"createTime":1147,"updateTime":1148,"relativeEntities":1149,"slug":1150,"properties":1151,"entityType":68,"verifyStatus":22,"verifyTime":23,"verifyNote":23,"syncStatus":22,"languages":23,"translateLanguages":23,"viewCount":24},"0243094d-c542-4432-a631-8a582e17918d","2024-04-19T20:07:49.409+00:00","2025-06-11T15:40:55.023+00:00",[],"Kazan-Volga-Region-Federal-University",{"title":1152},{"EN":1153},"Kazan (Volga Region) Federal University",{"openalex":1155,"orcid":1157,"title":1159},{"VOID":1156},"A5046752532",{"VOID":1158},"https:\u002F\u002Forcid.org\u002F0000-0002-4638-2142",{"EN":1160},"Diana V. 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Bondar",{"id":1194,"sortIndex":357,"researcher":23,"roles":1195,"affiliations":1196,"properties":1203},"bc221f3d-fd36-446b-9bae-557e60a64be6",[],[1197],{"id":1198,"sortIndex":24,"affiliation":1199,"properties":23},"d9eb86ab-9d07-4e9c-86e0-413c206884af",{"id":1146,"createTime":1147,"updateTime":1148,"relativeEntities":1200,"slug":1150,"properties":1201,"entityType":68,"verifyStatus":22,"verifyTime":23,"verifyNote":23,"syncStatus":22,"languages":23,"translateLanguages":23,"viewCount":24},[],{"title":1202},{"EN":1153},{"openalex":1204,"orcid":1206,"title":1208},{"VOID":1205},"A5071415828",{"VOID":1207},"https:\u002F\u002Forcid.org\u002F0000-0002-3030-3198",{"EN":1209},"Timur I. Abdullin",{"id":1211,"sortIndex":174,"researcher":23,"roles":1212,"affiliations":1213,"properties":1220},"d4259eb8-7544-4b0c-840f-62ccb60e1d43",[],[1214],{"id":1215,"sortIndex":24,"affiliation":1216,"properties":23},"35d6b11f-2aad-4f6d-b32e-7178f75c21a5",{"id":1146,"createTime":1147,"updateTime":1148,"relativeEntities":1217,"slug":1150,"properties":1218,"entityType":68,"verifyStatus":22,"verifyTime":23,"verifyNote":23,"syncStatus":22,"languages":23,"translateLanguages":23,"viewCount":24},[],{"title":1219},{"EN":1153},{"openalex":1221,"title":1223},{"VOID":1222},"A5070992526",{"EN":1224},"Irina I. Shakhmaeva",{"url":23,"publisher":1226,"properties":1251},{"id":6,"createTime":7,"updateTime":8,"relativeEntities":1227,"slug":10,"properties":1228,"entityType":21,"verifyStatus":22,"verifyTime":23,"verifyNote":23,"syncStatus":22,"languages":23,"translateLanguages":23,"viewCount":24,"subjectFields":1234,"manageAffiliations":1235,"indexDatabases":1236,"url":112,"thumbnailPath":23,"statistic":23,"gsStatistic":23,"type":23,"analyzePriority":23},[],{"country":1229,"issn":1230,"introduce":1231,"eissn":1232,"title":1233},{"VOID":13},{"VOID":15},{"EN":17},{"VOID":15},{"EN":20},[],[],[1237,1244],{"id":72,"indexDatabase":1238,"url":87,"indexYears":23,"academicFieldIds":1243,"indexDatabaseRanking":23},{"id":74,"createTime":75,"updateTime":76,"relativeEntities":1239,"label":1240,"description":1241,"key":83,"publicationTags":1242,"standard":23},[],{"EN":79,"VI":79},{"VI":81,"EN":82},[85,86],[89],{"id":91,"indexDatabase":1245,"url":104,"indexYears":105,"academicFieldIds":1250,"indexDatabaseRanking":111},{"id":93,"createTime":94,"updateTime":95,"relativeEntities":1246,"label":1247,"description":1248,"key":101,"publicationTags":1249,"standard":23},[],{"EN":98,"VI":98},{"EN":98,"VI":100},[103],[107,108,109,110],{"volume":1252,"pages":1253,"issue":1255},{"VOID":265},{"VOID":1254},"78-81",{"VOID":1256},"1",130,{"total":1257,"publishYear":23,"statisticByYear":1259},{"2013":217,"2014":960,"2015":552,"2016":1260,"2017":1261,"2018":960,"2019":1108,"2020":1260,"2021":1107,"2022":1262,"2023":552,"2024":266},12,15,14,[],{"id":1265,"createTime":1266,"updateTime":1267,"relativeEntities":1268,"slug":1269,"properties":1270,"entityType":142,"verifyStatus":143,"verifyTime":1266,"verifyNote":144,"syncStatus":22,"languages":1288,"translateLanguages":1289,"viewCount":24,"primaryUrl":1290,"fullTextUrl":23,"authors":1291,"publicationType":233,"publisherRelationship":1346,"citationCount":1378,"citationInfo":1379,"publishDate":23,"publishYear":23,"citationAnalyzeStatus":22,"lastCitationAnalyze":23,"indexDatabases":23,"openAccess":23,"references":1386,"isForceReanalyzing":270},"2c2c1bd4-9e8b-47bd-bfc7-3e000d2749b2","2024-09-12T06:02:49.874+00:00","2025-01-01T11:27:55.231+00:00",[],"Bacterial-Enzymes-and-Antibiotic-Resistance",{"mag":1271,"keywords":1273,"pmc":1274,"openalex":1276,"abstract":1278,"title":1281,"pm":1284,"doi":1286},{"VOID":1272},"2915573887",{"VI":281},{"VOID":1275},"6351036",{"VOID":1277},"W2915573887",{"VI":1279,"EN":1280},"\u003Cjats:p>Khả năng kháng kháng sinh của vi sinh vật đã phát triển trong hơn 2 tỷ năm và được phân bố rộng rãi giữa nhiều đại diện khác nhau của thế giới vi sinh vật. Các enzyme của vi khuẩn đóng vai trò chủ chốt trong sự xuất hiện của khả năng kháng. Phân loại các enzyme này dựa trên sự tham gia của chúng vào các cơ chế sinh hóa khác nhau: sửa đổi các enzyme đóng vai trò là mục tiêu kháng sinh, sửa đổi enzym của các mục tiêu nội bào, biến đổi enzym của các loại kháng sinh và thực hiện các phản ứng trao đổi chất của tế bào. Các cơ chế chính của sự phát triển khả năng kháng liên quan đến sự tiến hóa của các siêu họ enzyme vi khuẩn do sự biến đổi của các gen mã hóa chúng. Tập hợp tất cả các gen kháng kháng sinh được gọi là resistome. Hàng chục nghìn enzyme và các đột biến của chúng thực hiện các cơ chế kháng khác nhau tạo thành một cộng đồng mới được gọi là enzystome. Phân tích cấu trúc và các đặc điểm chức năng của các enzyme, là mục tiêu cho các lớp kháng sinh khác nhau, sẽ cho phép chúng ta phát triển các chiến lược mới để vượt qua khả năng kháng.\u003C\u002Fjats:p>","\u003Cjats:p>The resistance of microorganisms to antibiotics has been developing for more than 2 billion years and is widely distributed among various representatives of the microbiological world. Bacterial enzymes play a key role in the emergence of resistance. Classification of these enzymes is based on their participation in various biochemical mechanisms: modification of the enzymes that act as antibiotic targets, enzymatic modification of intracellular targets, enzymatic transformation of antibiotics, and the implementation of cellular metabolism reactions. The main mechanisms of resistance development are associated with the evolution of superfamilies of bacterial enzymes due to the variability of the genes encoding them. The collection of all antibiotic resistance genes is known as the resistome. Tens of thousands of enzymes and their mutants that implement various mechanisms of resistance form a new community that is called the enzystome. Analysis of the structure and functional characteristics of enzymes, which are the targets for different classes of antibiotics, will allow us to develop new strategies for overcoming the resistance.\u003C\u002Fjats:p>",{"VI":1282,"EN":1283},"Enzymes vi sinh vật và khả năng kháng kháng sinh","Bacterial Enzymes and Antibiotic Resistance",{"VOID":1285},"30713760",{"VOID":1287},"10.32607\u002F20758251-2018-10-4-33-48",[146],[148],"http:\u002F\u002Factanaturae.ru\u002F2075-8251\u002Farticle\u002Fview\u002F10309",[1292,1314,1331],{"id":1293,"sortIndex":24,"researcher":23,"roles":1294,"affiliations":1295,"properties":1307},"03de5e92-d396-45f1-9469-a97a52af419f",[],[1296],{"id":1297,"sortIndex":24,"affiliation":1298,"properties":23},"cbcab1a1-6ab0-4a3f-977d-bb46510b0bb8",{"id":1299,"createTime":1300,"updateTime":1301,"relativeEntities":1302,"slug":1303,"properties":1304,"entityType":68,"verifyStatus":22,"verifyTime":23,"verifyNote":23,"syncStatus":22,"languages":23,"translateLanguages":23,"viewCount":24},"31b5a049-21cb-47c7-bc8e-76a5f39f0f6f","2024-04-18T23:43:40.779+00:00","2024-11-26T17:27:03.175+00:00",[],"M-V-Lomonosov-Moscow-State-University",{"title":1305},{"EN":1306},"M.V. 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