Welfare and research and development incentive effects of uniform and differential pricing schemes

Giorgio Gnecco1, Fabio Pammolli2, Berna Tuncay3
1IMT School for Advanced Studies, Lucca, Italy
2Department of Management Engineering, and CADS, Human Technopole, Polytechnic University of Milan, Milan, Italy
3Ozyegin University, İstanbul, Turkey

Tóm tắt

AbstractThis paper is about the application of optimization methods to the analysis of three pricing schemes adopted by one manufacturer in a two-country model of production and trade. The analysis focuses on pricing schemes—one uniform pricing scheme, and two differential pricing schemes—for which there is no competition coming from the so-called parallel trade. This term denotes the practice of buying a patented product like a medicine in one market at one price, then re-selling it in a second so-called gray market at a higher price, on a parallel distribution chain where it competes with the official distribution chain. The adoption of pricing schemes under which parallel trade does not arise can prevent the occurrence of its well-documented negative effects. In the work, a comparison of the optimal solutions to the optimization problems modeling the three pricing schemes is performed. More specifically, conditions are found under which the two differential pricing schemes are more desirable from several points of view (e.g., incentive for the manufacturer to do Research and Development, product accessibility, global welfare) than the uniform pricing scheme. In particular, we prove that, compared to the uniform pricing scheme, the two differential pricing schemes increase the incentive for the manufacturer to invest in Research and Development. We also prove that they serve both countries under a larger range of values for the relative market size, making the product more accessible to consumers in the lower price country. Moreover, we provide a sufficient condition under which price discrimination is more efficient from a global welfare perspective than uniform pricing. The analysis applies in particular to the case of the European Single Market for medicines. Compared to other studies, our work takes into account also the possible presence in all the optimization problems of a positive constant marginal cost of production, showing that it can have non-negligible effects on the results of the analysis. As an important contribution, indeed, our analysis clarifies the conditions—which have been overlooked in the literature about the mechanisms adopted to prevent parallel trade occurrence—that allow/do not allow one to neglect the presence of this factor. Such conditions are related, e.g., to the comparison between the positive constant marginal cost of production, the parallel trade cost per-unit, and the maximal price that can be effectively charged to the consumers in the lower price country.

Từ khóa


Tài liệu tham khảo

Acemoglu D, Linn J (2004) Market size in innovation: theory and evidence from the pharmaceutical industry. Q J Econ 119(3):1049–1090

Ahmadi R, Iravani F, Mamanin H (2015) Coping with gray markets: the impact of market conditions and product characteristics. Prod Oper Manag 24:762–777

Alexandrov A, Deb J (2012) Price discrimination and investment incentives. Int J Ind Organ 30:615–623

Bertsekas DP (2004) Nonlinear programming. Athena Scientific, Belmont

Bertsekas DP (2015) Dynamic programming and optimal control, vol 1. Athena Scientific, Belmont

Boyd S, Vandenberghe L (2004) Convex optimization. Cambridge University Press, Cambridge

Chen Y, Maskus KE (2005) Vertical price control and parallel imports. J Int Trade Econ Dev 14(1):1–18

Danzon PM (1998) The economics of parallel trade. Pharmaeconomics 13(3):293–304

Danzon PM, Towse A (2003) Differential pricing for pharmaceuticals: reconciling access, R&D and patents. Int J Health Care Finance Econ 3(3):183–205

Danzon PM, Towse A, Mestre-Ferrandiz J (2015) Value-based differential pricing: efficient pricing for drugs in a global context. Health Econ 24(3):294–301

Duso T, Herr A, Suppliet M (2014) The welfare impact of parallel imports: a structural approach applied to the German market for oral anti-diabetics. Health Econ 23(9):1036–1057

Gaggero M, Gnecco G, Sanguineti M (2014) Approximate dynamic programming for stochastic N-stage optimization with application to optimal consumption under uncertainty. Comput Optim Appl 58(1):31–85

Ganslandt M, Maskus KE (2004) Parallel imports and the pricing of pharmaceutical products: evidence from the European Union. J Health Econ 23(5):1035–1057

Gibbons R (1992) Game theory for applied economists. Princeton University Press, Princeton

Gnecco G, Sanguineti M (2010) Suboptimal solutions to dynamic optimization problems via approximations of the policy functions. J Optim Theory Appl 146(3):764–794

Gnecco G, Tuncay B, Pammolli F (2018) A comparison of game-theoretic models for parallel trade. Int Game Theory Rev 20(3):1–57

Guo S, Hu B, Zhong H (2013) Impact of parallel trade on pharmaceutical firm’s profits: rise or fall? Eur J Health Econ 14(2):345–355

Hausman JA, MacKie-Mason JK (1988) Price discrimination and patent policy. RAND J Econ 19(2):253–265

Jelovac I, Bordoy C (2005) Pricing and welfare implications of parallel imports in the pharmaceutical industry. Int J Health Care Finance Econ 5(1):5–21

Kanavos P, Vandoros S, Irwin R, Nicod E, Casson M (2011) Differences in costs of and access to pharmaceutical products in the EU. Directorate-General for Internal Policies, European Parliament. http://www.europarl.europa.eu/RegData/etudes/etudes/join/2011/451481/IPOL-ENVI_ET(2011)451481_EN.pdf

Li C, Robles J (2006) Product innovation and parallel trade. Int J Ind Organ 25:417–429

Liu Q, Shuai J (2013) Multi-dimensional price discrimination. Int J Ind Organ 31:417–428

Luenberger DG (1969) Optimization by vector space methods. Wiley, London

Maini L, Pammolli F (2020) Reference pricing as a deterrent to entry: evidence from the European pharmaceutical market. Working paper. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3694471

Maskus KE, Chen Y (2004) Vertical price control and parallel imports: theory and evidence. Rev Int Econ 12(4):551–570

Maskus KE, Ganslandt M (2002) Parallel trade in pharmaceutical products: implications for procuring medicines for poor countries. In: Granville B (ed) The economics of essential medicines. Royal Institute of International Affairs, London, pp 57–80

Matteucci G, Reverberi P (2017) Drug innovation, price controls, and parallel trade. Int J Health Econ Manag 17(2):159–179

Müller-Langer F (2009) Creating R&D incentives for medicines for neglected diseases. Springer, Berlin

Müller-Langer F (2009) Does parallel trade freedom harm consumers in small markets? Croat Econ Surv 1(11):11–41

Müller-Langer F (2012) Parallel trade and its ambiguous effects on global welfare. Rev Int Econ 20(1):177–185

Nocedal J, Wright SJ (2006) Numerical optimization. Springer, Berlin

Pammolli F, Rungi A (2016) Access to medicines and European market integration. IMT Lucca EIC working paper series #01/2016. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2717501

Ramsey FP (1927) A contribution to the theory of taxation. Econ J 37(145):47–61

Schmalensee R (1981) Output and welfare implications of monopolistic third-degree price discrimination. Am Econ Rev 71(1):242–247

Scott Morton F, Kyle M (2012) Markets for pharmaceutical products. In: Pauly M, McGuire TG, Barros PP (eds) Handbook of health economics, vol 2. North-Holland, Oxford, pp 763–824

Sutton J (1998) Technology and market structure: theory and history. MIT Press, Cambridge

Towse A (1998) The pros and cons of a single “Euro-price” for drug. Pharmacoeconomics 13(3):271–276

Towse A, Pistollato M, Mestre-Ferrandiz J, Khan Z, Kaura S, Garrison L (2015) European Union pharmaceutical markets: a case for differential pricing? Int J Econ Bus 22(2):263–275

Valletti TM (2006) Differential pricing, parallel trade, and the incentive to invest. J Int Econ 70(1):314–324

Zhang J (2016) The benefits of consumer rebates: a strategy for gray market deterrence. Eur J Oper Res 251(2):509–521