The ultrastructure of the accessory sex organs of the male rat
Tóm tắt
The fine structure of the nuclei of epithelial cells of the dorsal lobe of the rat prostate were studied after administration of three different antiandrogenic compounds. The nucleolus appears to undergo a progressive disorganisation with partial fragmentation and dispersion of its normal components. Different types of intranuclear inclusions were found. The various alterations observed were often encountered within the same section. This may indicate that the nuclear alterations occur in the same compartment of the cell, and represent a dysfunction of integrated biochemical events occurring within this compartment. The findings support a view that the stimulatory secretory effect of androgens is mediated via a ‘secretory center’, located within the nucleolusassociated chromatin. Within this ‘secretory center’, the initial steps of the secretory process, the binding of the DHT receptor complex to DNA is assumed to occur.
Tài liệu tham khảo
Anderson, K.M., Liao, S.: Selective retention of dihydrotestosterone by prostatic nuclei. Nature (Lond.) 219, 277–279 (1968)
Barry, M.C., Eidinoff, M.L., Dobriner, K., Gallagher, T.F.: Fate of C14-testosterone and C14-progesterone in mice and rats. Endocrinology 50, 587–599 (1952)
Baulieu, E.E., Lasnitzki, I., Robel, P.: Metabolism of testosterone and action of metabolism on prostate glands grown in organ culture. Nature (Lond.) 219, 1155–1156 (1968)
Bruchovsky, N., Wilson, J.D.: The conversion of testosterone to 5a-androstan-17B-013-one by rat prostate in vivo and in vitro. J. biol. Chem. 243, 2012–2021 (1968)
Dahl, E.: The fine structure of nuclear inclusions. J. Anat. (Lond.) 106, 255–262 (1970)
Dahl, E.: The ultrastructure of the accessory sex organs of the male rat. XI. Nuclear alterations of prostatic epithelial cells induced by castration. Cell Tiss. Res. 171, 285–296 (1976)
Dahl, E., Hars, R.: The ultrastructure of the accessory sex organs of the male rat. 10. Effect of chlormadinon. Acta endocr. (Kbh.) 80, 199–208 (1975)
Dahl, E., Kjaerheim, Å.: The ultrastructure of the accessory sex organs of the male rat. VI. The effect of cyproterone acetate on the dorsal lobe and the coagulating gland. Cell Tiss. Res. 148, 57–67 (1974)
Dahl, E., Kjaerheim, Å., Tveter, K.J.: The ultrastructure of the accessory sex organs of the male rat. 1. Normal structure. Z. Zellforsch. 137, 345–359 (1973)
Krishan, A., Uzman, B., Hedley-Whyte, E.T.: Nuclear bodies: a component of cell nuclei in hamster tissues and human tumors. J. Ultrastruct. Res. 19, 563–572 (1967)
Liao, S., Barton, R.W., Lin, A.H.: Differential synthesis of ribonucleic acid in prostatic nuclei: evidence for selective gene transcription induced by androgens. Proc. nat. Acad. Sci. (Wash.) 55, 1593–1600 (1966)
Mainwaring, W.I.P.: The binding of (1.2-3H) testosterone within the nucleus of the rat prostate. J. Endocr. 44, 323, 1969
Mainwaring, W.I.P.: A soluble androgen receptor in the cytoplasm of rat prostate. J. Endocr. 45, 531 (1969)
Mainwaring, W.I.P., Mangan, F.R.: In: Advances in the Biosciences 7 (G. Raspé, ed.). Braunschweig: Vieweg: Pergamon Press 1971
Neumann, F., Steinbeck, H.: Antiandrogens. In: Handb. Exp. Pharm., Vol. 35/2. Berlin-Heidelberg-New York: Springer 1974
Shinozuka, H., Martin, J.T., Farber, J.L.: The induction of fibrillar nucleoli in rat liver cells by D-Galactosamine and their subsequent Re-formation into normal nucleoli. J. Ultrastruct. Res. 44, 279–292 (1973)
Simard, R., Bernhard, W.: Le phénomène de la Ségrégation nucléolaire: spécificité d'action de certains antimétabolites. Int. J. Cancer 1, 463–479 (1966)
Tveter, K.J., Aakvaag, A.: Uptake and metabolism in vivo of testosterone-1, 2-3H by accessory sex organs of the male rats; influence of some hormonal compounds. Endocrinology 85, 683–689 (1969)
Tveter, K.J., Dahl, E.: The ultrastructure of the accessory sex organs of the male rat. 7. The effect of an anti-androgenic compound, SK and F22340. Urologic. Res. 2, 159–166 (1975)
Tveter, K.J., Unhjem, O., Attramadal, A., Aakvaag, A., Hansson, V.: In: Advances in the Biociences 7 (G. Raspé, ed.). Braunschweig: Vieweg: Pergamon Press 1971
Wagner, R.K., Hughes, A.: Current views on androgen receptors and mechanism of androgen action. In: Handb. Exp. Pharm., Vol. 35/2. Berlin-Heidelberg-New York: Springer 1974