Profile of Dr. Zi-Jiang Chen

Chen, X., Ke, Y., Wu, K., Zhao, H., Sun, Y., Gao, L., Liu, Z., Zhang, J., Tao, W., Hou, Z., et al. (2019). Key role for ctcf in establishing chromatin structure in human embryos. Nature 576, 306–310.

Chen, Z.J., Shi, Y., Sun, Y., Zhang, B., Liang, X., Cao, Y., Yang, J., Liu, J., Wei, D., Weng, N., et al. (2016). Fresh versus frozen embryos for infertility in the polycystic ovary syndrome. N Engl J Med 375, 523–533.

Chen, Z.J., Zhao, H., He, L., Shi, Y., Qin, Y., Shi, Y., Li, Z., You, L., Zhao, J., Liu, J., et al. (2011). Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet 43, 55–59.

Gao, L., Wu, K., Liu, Z., Yao, X., Yuan, S., Tao, W., Yi, L., Yu, G., Hou, Z., Fan, D., et al. (2018). Chromatin accessibility landscape in human early embryos and its association with evolution. Cell 173, 248–259.e15.

Guo, T., Zhao, S., Zhao, S., Chen, M., Li, G., Jiao, X., Wang, Z., Zhao, Y., Qin, Y., Gao, F., et al. (2017). Mutations in MSH5 in primary ovarian insufficiency. Human Mol Genets 26, 1452–1457.

Jiao, X., Ke, H., Qin, Y., and Chen, Z.J. (2018). Molecular genetics of premature ovarian insufficiency. Trends Endocrinol Metab 29, 795–807.

Li, M., Huang, T., Li, M.J., Zhang, C.X., Yu, X.C., Yin, Y.Y., Liu, C., Wang, X., Feng, H.W., Zhang, T., et al. (2019). The histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice. Sci Adv 5, eaax1101.

Liu, H., Huang, T., Li, M., Li, M., Zhang, C., Jiang, J., Yu, X., Yin, Y., Zhang, F., Lu, G., et al. (2019). SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice. Nucleic Acids Res 47, 5670–5683.

Liu, H., Muhammad, T., Guo, Y., Li, M., Sha, Q., Zhang, C., Liu, H., Zhao, S., Zhao, H., Zhang, H. (2019). RNA-binding protein IGF2BP2/IMP2 is a critical maternal activator in early zygotic genome activation. Advanced Sci1900295.

Qin, Y., Zhang, F., Chen, Z.J. (2019). BRCA2 in ovarian development and function. N Engl J Med 380, 1086.

Qin, Y., Jiao, X., Simpson, J.L., and Chen, Z.J. (2015). Genetics of primary ovarian insufficiency: new developments and opportunities. Hum Reprod Update 21, 787–808.

Qin, Y., Choi, Y., Zhao, H., Simpson, J.L., Chen, Z.J., and Rajkovic, A. (2007). NOBOX homeobox mutation causes premature ovarian failure. Am J Human Genets 81, 576–581.

Qin, Y., Guo, T., Li, G., Tang, T.S., Zhao, S., Jiao, X., Gong, J., Gao, F., Guo, C., Simpson, J.L., et al. (2015). CSB-PGBD3 mutations cause premature ovarian failure. PLoS Genet 11, e1005419.

Shi, Y., Sun, Y., Hao, C., Zhang, H., Wei, D., Zhang, Y., Zhu, Y., Deng, X., Qi, X., Li, H., et al. (2018). Transfer of fresh versus frozen embryos in ovulatory women. N Engl J Med 378, 126–136.

Shi, Y., Zhao, H., Shi, Y., Cao, Y., Yang, D., Li, Z., Zhang, B., Liang, X., Li, T., Chen, J., et al. (2012). Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nat Genet 44, 1020–1025.

Wei, D., Liu, J.Y., Sun, Y., Shi, Y., Zhang, B., Liu, J.Q., Tan, J., Liang, X., Cao, Y., Wang, Z., et al. (2019). Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial. Lancet 393, 1310–1318.

Wu, K., Zhong, C., Chen, T., Zhang, X., Tao, W., Zhang, J., Li, H., Zhao, H., Li, J., and Chen, Z.J. (2017). Polar bodies are efficient donors for reconstruction of human embryos for potential mitochondrial replacement therapy. Cell Res 27, 1069–1072.

Xiong, W. P., Wang, D. Y., Gao, Y., Gao, Y., Wang, H. Y., Guan, J., Lan, L., Yan, J.H., Zong, L., Yuan, Y., et al. (2015). Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment. Sci China Life Sci 58, 829–838.

Yuan, X., Hu, T., Zhao, H., Huang, Y., Ye, R., Lin, J., Zhang, C., Zhang, H., Wei, G., Zhou, H., et al. (2016). Brown adipose tissue transplantation ameliorates polycystic ovary syndrome. Proc Natl Acad Sci USA 113, 2708–2713.

Zhao, H., Chen, Z.J., Qin, Y., Shi, Y., Wang, S., Choi, Y., Simpson, J.L., and Rajkovic, A. (2008). Transcription factor FIGLA is mutated in patients with premature ovarian failure. Am J Human Genets 82, 1342–1348.