Process development for the production of the (S)-acid precursor of a novel elastase inhibitor (L-694,458) through the lipase-catalyzed kinetic resolution of a β-lactam benzyl ester

Journal of Fermentation and Bioengineering - Tập 83 - Trang 48-53 - 1997
Christopher Roberge1, Raymond J. Cvetovich2, Joseph S. Amato2, Victor Pecore1, Frederick W. Hartner2, Randolph Greasham1, Michel Chartrain1
1Department of Bioproces Research and Development, Merck Research Laboratories, Rahway, NJ, USA
2Department of Process Research, Merck Research Laboratories, Rahway, NJ, USA

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