Prevention of Mammary Tumorigenesis in Acatalasemic Mice by Vitamin E Supplementation

Wiley - Tập 87 Số 7 - Trang 680-684 - 1996
K Ishii1, Li‐Xue Zhen2, Dahong Wang2, Yuka Funamori2, Katsuo Ogawa3, Kazuhisa Taketa2
1Department of Public health, Okayama University Medical School
2Department of Public Health, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700
3Shigei Medical Research Hospital, 2117‐18 Yamada, Okayama 701‐02

Tóm tắt

Adult male and female acatalasemic (C3H/AnLCsbCsb), hypocatalasemic (C3H/AnLCscCsc) and normal mice of C3H strain fed on regular laboratory chow for 15 months showed an increased incidence of spontaneous mammary tumor in the decreasing order of female acatalasemic, male acatalasemic, female hypocatalasemic and male hypocatalasemic mice. Normal mice did not develop mammary tumor. We conducted a prospective study with female acatalasemic mice, which showed the highest incidence of mammary tumor, to examine the preventive effect of vitamin E on mammary tumor. Female acatalasemic mice were fed on vitamin E‐deficient (28 animals) and vitamin E‐supplemented diet (25 animals) for 29 months. The incidence of mammary tumor in mice given the vitamin E‐supplemented diet was 47%, while that in mice given vitamin E‐deficient diet was 82% (P<0.002). Mammary tumors were apparent after 9 months of vitamin E deprivation and after 14 months of vitamin E supplementation. Female normal mice did not develop mammary tumor during a comparable period of time. The mean catalase activity of mammary gland in acatalasemic mice was 18.8% of that in normal mice. The results indicate that vitamin E protects acatalasemic mice against the development of mammary tumor.

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Wiley

Tập 87 Số 7

680-684

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