Moderate and severe traumatic brain injury in adults
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Cole, 2004, Global road safety crisis remedy sought: 1·2 million killed, 50 million injured annually, JAMA, 291, 2531, 10.1001/jama.291.21.2531
Redelmeier, 2003, Traffic-law enforcement and risk of death from motor-vehicle crashes: case-crossover study, Lancet, 361, 2177, 10.1016/S0140-6736(03)13770-1
Foulkes, 1991, The Traumatic Coma Data Bank; design, methods and baseline characteristics, J Neurosurg, 75, S1, 10.3171/sup.1991.75.1s.00s1
Murray, 1999, Head injuries in four British neurosurgical centres, Br J Neurosurg, 13, 564, 10.1080/02688699943060
Murray, 1999, The European Brain Consortium survey of head injuries, Acta Neurochir (Wien), 141, 223, 10.1007/s007010050292
Rusnak, 2007, Severe traumatic brain injury in Austria. I: Introduction to the study, Wien Klin Wochenschr, 119, 23, 10.1007/s00508-006-0760-5
Butcher, 2007, The prognostic value of cause of injury in traumatic brain injury: results from the IMPACT study, J Neurotrauma, 24, 281, 10.1089/neu.2006.0030
Jiang, 2007, Violent trauma in China: report of 2254 cases, Surg Neurol, 68, 2, 10.1016/j.surneu.2007.09.016
Langlois, 2006
Tagliaferri, 2006, A systematic review of brain injury epidemiology in Europe, Acta Neurochir (Wien), 148, 255, 10.1007/s00701-005-0651-y
Hillier, 1997, Epidemiology of traumatic brain injury in South Australia, Brain Inj, 11, 649, 10.1080/026990597123205
Thornhill, 2000, Disability in young people and adults one year after head injury: prospective cohort study, BMJ, 320, 1631, 10.1136/bmj.320.7250.1631
Polinder, 2005, Cost estimation of injury-related hospital admissions in 10 European countries, J Trauma, 59, 1283, 10.1097/01.ta.0000195998.11304.5b
Polinder, 2007, Assessing the burden of injury in six European countries, Bull World Health Organ, 85, 27, 10.2471/BLT.06.030973
Thurman, 2001, Epidemiology and economics of head trauma, 1193
Sobocki, 2007, Brain research has high returns but Europe is lagging behind, Eur J Neurol, 14, 708, 10.1111/j.1468-1331.2007.01816.x
Gennarelli, 1990, Mortality in patients with head injury and extracranial injury treated in trauma centers, J Trauma, 29, 1193, 10.1097/00005373-198909000-00002
Teasdale, 1974, Assessment of coma and impaired consciousness. A practical scale, Lancet, 2, 81, 10.1016/S0140-6736(74)91639-0
Marshall, 1991, A new classification of head injury based on computerized tomography, J Neurosurg, 75, s14, 10.3171/sup.1991.75.1s.0s14
Balestreri, 2004, Predictive value of Glasgow Coma Scale after brain trauma: change in trend over the past ten years, J Neurol Neurosurg Psychiatry, 75, 161
Stocchetti, 2004, Inaccurate early assessment of neurological severity in head injury, J Neurotrauma, 21, 1131, 10.1089/neu.2004.21.1131
Maas, 2005, Prediction of outcome in traumatic brain injury with computed tomographic characteristics: a comparison between the computed tomographic classification and combinations of computed tomographic predictors, Neurosurgery, 57, 1173, 10.1227/01.NEU.0000186013.63046.6B
Steyerberg EW, Mushkudiani N, Perel P, et al. Predicting outcome after traumatic brain injury: development and international validation of prognostic scores based on admission characteristics. PLoS Med 2008 (in press).
2008, Predicting outcome after traumatic brain injury: practical prognostic models based on large cohort of international patients, BMJ, 336, 425, 10.1136/bmj.39461.643438.25
Menon, 2008, Prognostic modelling in traumatic brain injury, BMJ, 336, 397, 10.1136/bmj.39461.616991.80
Maas AI, Lingsma HF. New approaches to increase statistical power in TBI trials: insights from the IMPACT study group. Acta Neurochir (Wien) 2008 (in press).
Graham, 2002, Trauma, vol 1, 823
Zoroya, 2007, Scientists: brain injuries from war worse than thought, USA Today
Taber, 2006, Blast-related traumatic brain injury: what is known?, J Neuropsychiatry Clin Neurosci, 18, 141, 10.1176/appi.neuropsych.18.2.141
Armonda, 2006, Wartime traumatic cerebral vasospasm: recent review of combat casualties, Neurosurgery, 59, 1215, 10.1227/01.NEU.0000249190.46033.94
Stein, 2002, Intravascular coagulation: a major secondary insult in nonfatal traumatic brain injury, J Neurosurg, 97, 1373, 10.3171/jns.2002.97.6.1373
Harhangi, 2008, Coagulation disorders after traumatic brain injury, Acta Neurochir (Wien), 150, 165, 10.1007/s00701-007-1475-8
Clark, 2008, Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness, Autophagy, 4, 88, 10.4161/auto.5173
Lai, 2008, Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester, J Cereb Blood Flow Metab, 28, 540, 10.1038/sj.jcbfm.9600551
Morganti-Kossmann, 2002, Inflammatory response in acute traumatic brain injury: a double-edged sword, Curr Opin Crit Care, 8, 101, 10.1097/00075198-200204000-00002
Kroemer, 2007, Mitochondrial membrane permeabilization in cell death, Physiol Rev, 87, 99, 10.1152/physrev.00013.2006
Büki, 1999, Moderate posttraumatic hypothermia decreases early calpain-mediated proteolysis and concomitant cytoskeletal compromise in traumatic axonal injury, Exp Neurol, 159, 319, 10.1006/exnr.1999.7139
Diringer, 2002, Regional cerebrovascular and metabolic effects of hyperventilation after severe traumatic brain injury, J Neurosurg, 96, 103, 10.3171/jns.2002.96.1.0103
Coles, 2002, Effect of hyperventilation on cerebral blood flow in traumatic head injury: clinical relevance and monitoring correlates, Crit Care Med, 30, 1950, 10.1097/00003246-200209000-00002
Vespa, 2005, Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study, J Cereb Blood Flow Metab, 25, 763, 10.1038/sj.jcbfm.9600073
Oertel, 2005, Posttraumatic vasospasm: the epidemiology, severity, and time course of an underestimated phenomenon: a prospective study performed in 299 patients, J Neurosurg, 103, 812, 10.3171/jns.2005.103.5.0812
Chieregato, 2006, Xenon-CT and transcranial Doppler in poor-grade or complicated aneurysmatic subarachnoid hemorrhage patients undergoing aggressive management of intracranial hypertension, Intensive Care Med, 32, 1143, 10.1007/s00134-006-0226-2
Smits, 2007, Predicting intracranial traumatic findings on computed tomography in patients with minor head injury: the CHIP prediction rule, Ann Intern Med, 146, 397, 10.7326/0003-4819-146-6-200703200-00004
1996, Guidelines for minor head injured patients' management in adult age, J Neurosurg Sci, 40, 11
Vos, 2002, EFNS guideline on mild traumatic brain injury: report of an EFNS task force, Eur J Neurol, 9, 207, 10.1046/j.1468-1331.2002.00407.x
Haydel, 2000, Indications for computed tomography in patients with minor head injury, N Engl J Med, 343, 100, 10.1056/NEJM200007133430204
Stiell, 2001, The Canadian CT Head Rule for patients with minor head injury, Lancet, 357, 1391, 10.1016/S0140-6736(00)04561-X
Green, 1990, Intraorbital wood. Detection by magnetic resonance imaging, Ophthalmology, 97, 608, 10.1016/S0161-6420(90)32549-6
Huisman, 2004, Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury, ANJR Am J Neuroradiol, 25, 370
Parizel, 2005, New developments in the neuroradiological diagnosis of craniocerebral trauma, Eur Radiol, 15, 569, 10.1007/s00330-004-2558-z
Servadei, 2000, The value of the “worst” computed tomographic scan in clinical studies of moderate and severe head injury. European Brain Injury Consortium, Neurosurgery, 46, 70, 10.1097/00006123-200001000-00014
Chang, 2006, Acute traumatic intraparenchymal hemorrhage: risk factors for progression in the early post-injury period, Neurosurgery, 58, 647, 10.1227/01.NEU.0000197101.68538.E6
Oertel, 2002, Progressive hemorrhage after head trauma: predictors and consequences of the evolving injury, J Neurosurg, 96, 109, 10.3171/jns.2002.96.1.0109
Narayan, 2008, Progression of traumatic intracerebral hemorrhage: a prospective observational study, J Neurotrauma, 25, 629, 10.1089/neu.2007.0385
Maas, 1997, EBIC guidelines for management of severe head injury in adults. European Brain Injury Consortium, Acta Neurochir (Wien), 139, 286, 10.1007/BF01808823
Brenner, 2007, Computed tomography—an increasing source of radiation exposure, N Engl J Med, 357, 2277, 10.1056/NEJMra072149
Aarabi, 2001, Management and prognosis of penetrating brain injury—guidelines, J Trauma, 51, S1
Bullock, 1996, Guidelines for the management of severe head injury, J Neurotrauma, 13, 639
Bullock, 2000, Management and prognosis of severe traumatic brain injury. Guidelines for the management of severe traumatic brain injury, J Neurotrauma, 17, 451
Adelson, 2003, Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents, Pediatr Crit Care Med, 4, S1
Bullock, 2006, Guidelines for the surgical management of traumatic brain injury, Neurosurgery, 58, 1
2007, Guidelines for the management of severe traumatic brain injury, J Neurotrauma, 24, S1
Bartlett, 1998, Guidelines for the initial management of head injuries. Recommendations from the Society of British Neurological Surgeons, Br J Neurosurg, 12, 349, 10.1080/02688699844871
Newcombe, 1999, The management of acute neurotrauma in rural and remote locations: a set of guidelines for the care of head and spinal injuries, J Clin Neurosci, 6, 85, 10.1016/S0967-5868(99)90619-7
Patel, 2005, Trends in head injury outcome from 1989 to 2003 and the effect of neurosurgical care: an observational study, Lancet, 366, 1538, 10.1016/S0140-6736(05)67626-X
Thillai, 2000, Neurosurgical units working beyond safe capacity, BMJ, 320, 399, 10.1136/bmj.320.7232.399
Varelas, 2004, The impact of a neurointensivist-led team on a semiclosed neurosciences intensive care unit, Crit Care Med, 32, 2191, 10.1097/01.CCM.0000146131.03578.21
Suarez, 2004, Length of stay and mortality in neurocritically ill patients: impact of a specialized neurocritical care team, Crit Care Med, 32, 2311, 10.1097/01.CCM.0000146132.29042.4C
Visca, 2006, Clinical and neuroimaging features of severely brain-injured patients treated in a neurosurgical unit compared with patients treated in peripheral non-neurosurgical hospitals, Br J Neurosurg, 20, 82, 10.1080/02688690600682416
Seeley, 2001, Implementing the Galasko Report on the management of head injuries: the Eastern Region approach, Emerg Med J, 18, 358, 10.1136/emj.18.5.358
MacKenzie, 2006, A national evaluation of the effect of trauma-center care on mortality, N Engl J Med, 354, 366, 10.1056/NEJMsa052049
Miller, 1993, Management of intracranial hypertension in head injury: matching treatment with cause, Acta Neurochir Suppl (Wien), 57, 152
McHugh, 2007, Prognostic value of secondary insults in traumatic brain injury: results from the IMPACT study, J Neurotrauma, 24, 287, 10.1089/neu.2006.0031
Silverstone, 1989, Pulse oxymetry at the roadside: a study of pulse oxymetry in immediate care, BMJ, 298, 711, 10.1136/bmj.298.6675.711
Stocchetti, 1996, Hypoxemia and arterial hypotension at the accident scene in head injury, J Trauma, 40, 764, 10.1097/00005373-199605000-00014
DeWitt, 1995, Enhanced vulnerability to secondary ischemic insults after experimental traumatic brain injury, New Horiz, 3, 376
Winchell, 1997, Endotracheal intubation in the field improves survival in patients with severe head injury, Arch Surg, 132, 592, 10.1001/archsurg.1997.01430300034007
Rudehill, 2002, Outcome of traumatic brain injuries in 1,508 patients: impact of prehospital care, J Neurotrauma, 19, 855, 10.1089/08977150260190447
Davis, 2003, The effect of paramedic rapid sequence intubation on outcome in patients with severe traumatic brain injury, J Trauma, 54, 444, 10.1097/01.TA.0000053396.02126.CD
Cooper, 2004, Prehospital hypertonic saline resuscitation of patients with hypotension and severe traumatic brain injury: a randomized controlled trial, JAMA, 291, 1350, 10.1001/jama.291.11.1350
2007, Saline or albumin for fluid resuscitation in patients with traumatic brain injury, N Engl J Med, 357, 874, 10.1056/NEJMoa067514
Vespa, 2006, Intensive insulin therapy reduces microdialysis glucose values without altering glucose utilization or improving the lactate/pyruvate ratio after traumatic brain injury, Crit Care Med, 34, 850, 10.1097/01.CCM.0000201875.12245.6F
Stocchetti, 2005, Hyperventilation in head injury: a review, Chest, 127, 1812, 10.1378/chest.127.5.1812
Polderman, 2003, Increases in spinal fluid osmolarity induced by mannitol, Crit Care Med, 31, 584, 10.1097/01.CCM.0000050287.68977.84
Muizelaar, 1983, Mannitol causes compensatory cerebral vasoconstriction and vasodilation in response to blood viscosity changes, J Neurosurg, 59, 822, 10.3171/jns.1983.59.5.0822
Shackford, 1998, Hypertonic saline resuscitation of patients with head injury: a prospective, randomized clinical trial, J Trauma, 44, 50, 10.1097/00005373-199801000-00004
Suarez, 1998, Treatment of refractory intracranial hypertension with 23·4% saline, Crit Care Med, 26, 1118, 10.1097/00003246-199806000-00038
Ware, 2005, Effects of 23·4% sodium chloride solution in reducing intracranial pressure in patients with traumatic brain injury: a preliminary study, Neurosurgery, 57, 727, 10.1227/01.NEU.0000175726.08903.0A
Wakai, 2005, Mannitol for acute traumatic brain injury, Cochrane Database Syst Rev, 4, 10.1002/14651858.CD001049.pub2
Battison, 2005, Randomized, controlled trial on the effect of a 20% mannitol solution and a 7·5% saline/6% dextran solution on increased intracranial pressure after brain injury, Crit Care Med, 33, 196, 10.1097/01.CCM.0000150269.65485.A6
Citerio, 2007, Refractory elevated intracranial pressure: intensivist's role in solving the dilemma of decompressive craniectomy, Intensive Care Med, 33, 45, 10.1007/s00134-006-0381-5
Münch, 2000, Management of severe traumatic brain injury by decompressive craniectomy, Neurosurgery, 47, 315, 10.1097/00006123-200008000-00009
Servadei, 2007, The role of surgery in traumatic brain injury, Curr Opin Crit Care, 13, 163, 10.1097/MCC.0b013e32807f2a94
Polin, 1997, Decompressive bifrontal craniectomy in the treatment of severe refractory posttraumatic cerebral edema, Neurosurgery, 41, 84, 10.1097/00006123-199707000-00018
Reilly, 1975, Patients with head injury who talk and die, Lancet, 2, 375, 10.1016/S0140-6736(75)92893-7
Rockswold, 1993, Patients who talk and deteriorate, Ann Emerg Med, 22, 1004, 10.1016/S0196-0644(05)82742-8
Morris, 1998, Neurological deterioration as a potential alternative endpoint in human clinical trials of experimental pharmacological agents for treatment of severe traumatic brain injuries, Neurosurgery, 43, 1369
Juul, 2000, Intracranial hypertension and cerebral perfusion pressure: influence on neurological deterioration and outcome in severe head injury, J Neurosurg, 92, 1, 10.3171/jns.2000.92.1.0001
Maas, 2006, Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial, Lancet Neurol, 5, 38, 10.1016/S1474-4422(05)70253-2
Cremer, 2005, Effect of intracranial pressure monitoring and targeted intensive care on functional outcome after severe head injury, Crit Care Med, 33, 2207, 10.1097/01.CCM.0000181300.99078.B5
Shafi, 2008, Intracranial pressure monitoring in brain-injured patients is associated with worsening of survival, J Trauma, 64, 335, 10.1097/TA.0b013e31815dd017
Bhatia, 2007, Neuromonitoring in the intensive care unit. I. Intracranial pressure and cerebral blood flow monitoring, Intensive Care Med, 33, 1263, 10.1007/s00134-007-0678-z
Citerio, 2004, Intracranial pressure. Part two: clinical applications and technology, Intensive Care Med, 30, 1882, 10.1007/s00134-004-2377-3
Poca, 2007, Is intracranial pressure monitoring in the epidural space reliable? Fact and fiction, J Neurosurg, 106, 548, 10.3171/jns.2007.106.4.548
Zanier, 2007, Intracranial pressure monitoring in intensive care: clinical advantages of a computerized system over manual recording, Crit Care, 11, R7, 10.1186/cc5155
Czarnik, 2007, Noninvasive measurement of intracranial pressure: is it possible?, J Trauma, 62, 207, 10.1097/01.ta.0000219128.29515.d5
Stocchetti, 2007, Could intracranial pressure in traumatic brain injury be measured or predicted noninvasively? Almost, Intensive Care Med, 33, 1682, 10.1007/s00134-007-0798-5
Van den Brink, 2000, Brain oxygen tension in severe head injury, Neurosurgery, 46, 868
Zauner, 2002, Brain oxygenation and energy metabolism: part I—biological function and pathophysiology, Neurosurgery, 51, 289
Suazo, 2000, CO2 reactivity and brain oxygen pressure monitoring in severe head injury, Crit Care Med, 28, 3268, 10.1097/00003246-200009000-00024
van Santbrink, 2003, Brain tissue oxygen response in severe traumatic brain injury, Acta Neurochir (Wien), 145, 429, 10.1007/s00701-003-0032-3
Robertson, 1989, Cerebral arteriovenous oxygen difference as an estimate of cerebral blood flow in comatose patients, J Neurosurg, 70, 222, 10.3171/jns.1989.70.2.0222
Chieregato, 2003, Normal jugular bulb oxygen saturation, J Neurol Neurosurg Psychiatry, 74, 784, 10.1136/jnnp.74.6.784
Stiefel, 2005, Reduced mortality rate in patients with severe traumatic brain injury treated with brain tissue oxygen monitoring, J Neurosurg, 103, 805, 10.3171/jns.2005.103.5.0805
Bouma, 1992, Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography, J Neurosurg, 77, 360, 10.3171/jns.1992.77.3.0360
Vajkoczy, 2000, Continuous monitoring of regional cerebral blood flow: experimental and clinical validation of a novel thermal diffusion microprobe, J Neurosurg, 93, 265, 10.3171/jns.2000.93.2.0265
Persson, 1992, Chemical monitoring of neurosurgical intensive care patients using intracerebral microdialysis, J Neurosurg, 76, 72, 10.3171/jns.1992.76.1.0072
Bergsneider, 1997, Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study, J Neurosurg, 86, 241, 10.3171/jns.1997.86.2.0241
Glenn, 2003, Energy dysfunction as a predictor of outcome after moderate or severe head injury: indices of oxygen, glucose, and lactate metabolism, J Cereb Blood Flow Metab, 23, 1239, 10.1097/01.WCB.0000089833.23606.7F
Hillered, 2005, Translational neurochemical research in acute human brain injury: the current status and potential future for cerebral microdialysis, J Neurotrauma, 22, 3, 10.1089/neu.2005.22.3
Imberti, 2002, Cerebral tissue PO2 and SjvO2 changes during moderate hyperventilation in patients with severe traumatic brain injury, J Neurosurg, 96, 97, 10.3171/jns.2002.96.1.0097
Vespa, 1999, Increased incidence and impact of nonconvulsive and convulsive seizures after traumatic brain injury as detected by continuous electroencephalographic monitoring, J Neurosurg, 91, 750, 10.3171/jns.1999.91.5.0750
Strong, 2002, Spreading and synchronous depressions of cortical activity in acutely injured human brain, Stroke, 33, 2738, 10.1161/01.STR.0000043073.69602.09
Dreier, 2006, Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations, Brain, 129, 3224, 10.1093/brain/awl297
Fabricius, 2006, Cortical spreading depression and peri-infarct depolarization in acutely injured human cerebral cortex, Brain, 129, 778, 10.1093/brain/awh716
Wilson, 1998, Structured interviews for the Glasgow Outcome Scale and the extended Glasgow Outcome Scale: guidelines for their use, J Neurotrauma, 15, 573, 10.1089/neu.1998.15.573
Owen, 2008, Functional neuroimaging of the vegetative state, Nat Rev Neurosci, 9, 235, 10.1038/nrn2330
von Steinbuechel, 2005, Assessment of health-related quality of life in persons after traumatic brain injury—development of the Qolibri, a specific measure, Acta Neurochir Suppl, 93, 43, 10.1007/3-211-27577-0_6
Murray, 2007, Multivariable prognostic analysis in traumatic brain injury: results from the IMPACT study, J Neurotrauma, 24, 329, 10.1089/neu.2006.0035
Mushkudiani, 2008, A systematic review finds methodological improvements necessary for prognostic models in determining traumatic brain injury outcomes, J Clin Epidemiol, 61, 331, 10.1016/j.jclinepi.2007.06.011
Perel, 2006, Systematic review of prognostic models in traumatic brain injury, BMC Med Inform Decis Mak, 10.1186/1472-6947-6-38
Hernandez, 2006, Adjustment for strong predictors of outcome in traumatic brain injury trials: 25% reduction in sample size requirements in the IMPACT study, J Neurotrauma, 23, 1295, 10.1089/neu.2006.23.1295
Marmarou, 1999, Effects of bradykinin antagonist bradycor (Deltibant, CP-1027) in severe traumatic brain injury: results of a multi-center, randomized, placebo-controlled trial, J Neurotrauma, 16, 431, 10.1089/neu.1999.16.431
Bailey, 1991, A trial of the effect of nimodipine on outcome after head injury, Acta Neurochir (Wien), 110, 97, 10.1007/BF01400674
1994, A multicenter trial of the efficacy of nimodipine on outcome after severe head injury. The European Study Group on Nimodipine in Severe Head Injury, J Neurosurg, 80, 797, 10.3171/jns.1994.80.5.0797
Harders, 1996, Traumatic subarachnoid hemorrhage and its treatment with nimodipine, J Neurosurg, 85, 82, 10.3171/jns.1996.85.1.0082
Morris, 1999, Failure of the competitive N-methyl-D-aspartate antagonist Selfotel (CGS 19755) in the treatment of severe head injury: results of two phase III clinical trials, J Neurosurg, 91, 737, 10.3171/jns.1999.91.5.0737
Marshall, 1998, A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury, J Neurosurg, 89, 519, 10.3171/jns.1998.89.4.0519
Grumme, 1995, Treatment of patients with severe head injury by triamcinolone: a prospective, controlled multicenter clinical trial of 396 cases, Res Exp Med (Berl), 195, 217, 10.1007/BF02576791
Gaab, 1994, “Ultrahigh” dexamethasone in acute brain injury. Results from a prospective randomized double-blind multicenter trial (GUDHIS), Zentralbl Neurochir, 55, 135
Edwards, 2005, Final results of MRC CRASH, a randomized placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months, Lancet, 365, 1957, 10.1016/S0140-6736(05)66552-X
Temkin, 2007, Magnesium sulfate for neuroprotection after traumatic brain injury: a randomized controlled study, Lancet Neurol, 6, 29, 10.1016/S1474-4422(06)70630-5
Robertson, 1999, Prevention of secondary ischemic insults after severe head injury, Crit Care Med, 27, 2086, 10.1097/00003246-199910000-00002
Maas, 1999, Why have recent trials of neuroprotective agents in head injury failed to show convincing efficacy? A pragmatic analysis and theoretical considerations, Neurosurgery, 44, 1286
Maas, 2007, Prognosis and clinical trial design in traumatic brain injury: the IMPACT study, J Neurotrauma, 24, 232, 10.1089/neu.2006.0024
Visser, 2001, Non-therapeutic research in the EU in adults incapable of giving consent?, Lancet, 357, 818, 10.1016/S0140-6736(00)04189-1
Tu, 2004, Impracticability of informed consent in the Registry of the Canadian Stroke Network, N Engl J Med, 350, 1414, 10.1056/NEJMsa031697
Corrigan, 2003, Consent is not enough—putting incompetent patients first in clinical trials, Lancet, 361, 2096, 10.1016/S0140-6736(03)13728-2
Kompanje, 2004, ‘Treat first, ask later?’ Emergency research in acute neurology and neurotraumatology in the European Union, Intensive Care Med, 30, 168, 10.1007/s00134-003-2044-0