Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long–Evans rat: Further development of a rodent model of autism

Behavioural Brain Research - Tập 200 Số 1 - Trang 33-41 - 2009
Sandy R. Shultz1, Derrick F. MacFabe2, Samantha P. Martin3, Jordana Jackson3, Roy Taylor3, Francis Boon3, Klaus‐Peter Ossenkopp1, Donald P. Cain1
1The Kilee Patchell-Evans Autism Research Group, Department of Psychology and Graduate Program in Neuroscience, University of Western Ontario, London, Canada
2The Kilee Patchell-Evans Autism Research Group, Departments of Psychology and Psychiatry, Division of Developmental Disabilities, University of Western Ontario, London, Canada
3The Kilee Patchell-Evans Autism Research Group, Department of Psychology, University of Western Ontario, London, Canada

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Arndt, 2005, The teratology of autism, Int J Dev Neurosci, 23, 189, 10.1016/j.ijdevneu.2004.11.001

DiCicco-Bloom, 2006, The developmental neurobiology of autism spectrum disorder, J Neurosci, 26, 6897, 10.1523/JNEUROSCI.1712-06.2006

Horvath, 1999, Gastrointestinal abnormalities in children with autistic disorder, J Pediatr, 135, 559, 10.1016/S0022-3476(99)70052-1

Jyonouchi, 2002, Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder, Neuropsychobiology, 46, 76, 10.1159/000065416

Nyhan, 1999, Neurological nonmetabolic presentation of propionic academia, Arch Neurol, 56, 1143, 10.1001/archneur.56.9.1143

Thompson, 1990, Sources of propionate in inborn errors of propionate metabolism, Metabolism, 39, 1133, 10.1016/0026-0495(90)90084-P

Bergersen, 2002, Immunogold cytochemistry identifies specialized membrane domains for monocarboxylate transport in the central nervous system, Neurochem Res, 27, 89, 10.1023/A:1014806723147

Maurer, 2004, Correlation between local monocarboxylate transporter 1 (MCT1) and glucose transporter 1 (GLUT1) densities in the adult rat brain, Neurosci Lett, 355, 105, 10.1016/j.neulet.2003.10.056

MacFabe, 2007, Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders, Behav Brain Res, 176, 149, 10.1016/j.bbr.2006.07.025

MacFabe, 2008, A novel rodent model of autism: intraventricular infusions of propionic acid increase locomotor activity and induce neuroinflammation and oxidative stress in discrete regions of adult rat brain, Am J Biochem Biotech, 4, 146, 10.3844/ajbbsp.2008.146.166

Wajner, 2004, The role of oxidative damage in the neuropathology of organic acidurias: insights from animal studies, J Inherit Metab Dis, 27, 427, 10.1023/B:BOLI.0000037353.13085.e2

Bonnet, 2000, Intracellular pH modulates spontaneous and epileptiform bioelectric cell coupling of hippocampal CA3-neurones, Eur Neuropsychopharmacol, 10, 97, 10.1016/S0924-977X(99)00063-2

Karuri, 1993, Selective cellular acidification and toxicity of weak organic acids in an acidic microenvironment, Br J Cancer, 68, 1080, 10.1038/bjc.1993.485

Cannizzaro, 2003, [3H]-DA release evoked by low pH medium and internal H+ accumulation in rat hypothalamic synaptosomes: involvement of calcium ions, Neurochem Int, 43, 9, 10.1016/S0197-0186(02)00211-5

Rorig, 1996, Intracellular acidification reduced gap junction coupling between immature rat neocortical pyramidal neurons, J Physiol, 490, 31, 10.1113/jphysiol.1996.sp021125

Severson, 2003, Midbrain serotonergic receptors neurons are central pH chemoreceptors, Nat Neurosci, 6, 1139, 10.1038/nn1130

Schulpis, 2001, Low serum biotinidase activity in children with valproic acid monotherapy, Epilepsia, 42, 1359, 10.1046/j.1528-1157.2001.47000.x

James, 2006, Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism, Am J Med Genet B Neuropsychiatr Genet, 141B, 947, 10.1002/ajmg.b.30366

Brass, 1988, Effects of propionate and carnitine on the hepatic oxidation of short- and medium-chain-length, fatty acids, Biochem J, 250, 819, 10.1042/bj2500819

Shultz, 2008, Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism, Neuropharmacology, 54, 901, 10.1016/j.neuropharm.2008.01.013

Andres, 2002, Molecular genetics and animal models in autistic disorder, Brain Res Bull, 57, 109, 10.1016/S0361-9230(01)00642-6

Chauhan, 2006, Oxidative stress in autism, Pathophysiology, 13, 171, 10.1016/j.pathophys.2006.05.007

Vargas, 2005, Neuroglial activation and neuroinflammation in the brain of patients with autism, Ann Neurol, 57, 67, 10.1002/ana.20315

Zwaigenbaum, 2005, Behavioral manifestations of autism in the first year of life, Int J Dev Neurosci, 23, 143, 10.1016/j.ijdevneu.2004.05.001

Brusque, 1999, Effect of chemically induced propionic academia on neurobehavioral development of rats, Pharmacol Biochem Behav, 64, 529, 10.1016/S0091-3057(99)00127-6

Shear, 2000, Creatine reduces 3-nitropropionic-acid-induced cognitive and motor abnormalities in rats, Neuroreport, 11, 1833, 10.1097/00001756-200006260-00007

Morris, 1984, Developments of a water-maze procedure for studying spatial learning in the rat, J Neurosci Method, 11, 47, 10.1016/0165-0270(84)90007-4

Kolb, 1985, Earlier is not always better: behavioral dysfunction and abnormal cerebral morphogenesis following neonatal cortical lesions in the rat, Behav Brain Res, 17, 25, 10.1016/0166-4328(85)90005-1

Paxinos, 1986

Cain, 1993, An examination of the relations between hippocampal long-term potentiation, kindling, afterdischarge, and place learning in the water maze, Hippocampus, 3, 153, 10.1002/hipo.450030208

Beiko, 1997, The effect of nonspatial water maze pretraining in rats subjected to serotonin depletion and muscarinic receptor antagonism: a detailed behavioral assessment of spatial performance, Behav Brain Res, 88, 201, 10.1016/S0166-4328(97)02298-5

Morris, 1989, Synaptic plasticity and learning: selective impairments in rats and blockade of long term potentiation in vivo by the N-methyl-d-asparate receptor antagonist AP5, J Neurosci, 9, 3040, 10.1523/JNEUROSCI.09-09-03040.1989

Whishaw, 1995, Similarities vs. differences in place learning and circadian activity in rats after fimbria-fornix section or ibotenate removal of hippocampal cells, Hippocampus, 5, 595, 10.1002/hipo.450050610

Beiko, 2004, Contribution of sex differences in the acute stress response to sex differences in water maze performance in the rat, Behav Brain Res, 151, 239, 10.1016/j.bbr.2003.08.019

Cain, 2003, Detailed behavioral analysis reveals both task strategies and spatial memory impairments in rats given bilateral middle cerebral artery stroke, Brain Res, 972, 64, 10.1016/S0006-8993(03)02486-7

Cain, 2006, Thalamic and hippocampal mechanisms in spatial navigation: a dissociation between brain mechanisms for learning how versus learning where to navigate, Behav Brain Res, 170, 241, 10.1016/j.bbr.2006.02.023

Cain, 1996, Detailed behavioral analysis of water maze acquisition under APV or CNQX: contribution of sensorimotor disturbances to drug-induced acquisition deficits, Behav Neurosci, 110, 86, 10.1037/0735-7044.110.1.86

Leung, 1996, Partial hippocampal kindling affects retention but not acquisition and place but not cue tasks on the radial arm maze, Behav Neurosci, 110, 1017, 10.1037/0735-7044.110.5.1017

Mittelbronn, 2001, Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude, Acta Neuropathol (Berl), 110, 249, 10.1007/s004010000284

Shi, 2001, Antigen retrieval techniques: current perspectives, J Histochem Cytochem, 49, 931, 10.1177/002215540104900801

Ossenkopp, 1985, The measurement and integration of behavioral variables: aggregation and complexity as important issues, Neurobehav Toxicol Teratol, 7, 95

Whishaw, 1997, Perseveration on place reversals in spatial swimming pool tasks: further evidence for place learning in hippocampal rats, Hippocampus, 7, 361, 10.1002/(SICI)1098-1063(1997)7:4<361::AID-HIPO2>3.0.CO;2-M

Hoh, 2003, Role of the neocortex in the water maze task in the rat: a detailed behavioral and Golgi-Cox analysis, Behav Brain Res, 138, 81, 10.1016/S0166-4328(02)00237-1

Kenton, 2008, Combined but not individual administration of β-adrenergic and serotonergic antagonists impairs water maze acquisition in the rat, Neuropsychopharmacology, 33, 1298, 10.1038/sj.npp.1301518

Pettenuzzo, 2002, Ascorbic acid prevents cognitive deficits caused by chronic administration of propionic acid to rats in the water maze., Pharmacol Biochem Behav, 73, 623, 10.1016/S0091-3057(02)00856-0

Stoll, 1999, The role of microglia and macrophages in the pathophysiology of the CNS, Prog Neurobiol, 58, 233, 10.1016/S0301-0082(98)00083-5

Whitton, 2007, Inflammation as a causative factor in the aetiology of Parkinson's disease, Br J Pharmacol, 150, 963, 10.1038/sj.bjp.0707167

Zilka, 2006, Neuroinflammation in Alzheimer's disease: protector or promoter?, Bratisl Lek Listy, 107, 374

Dringen, 2005, Oxidative and antioxidative potential of brain microglial cells, Antioxid Redox Signal, 7, 1223, 10.1089/ars.2005.7.1223

Le Poul, 2003, Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation, J Biol Chem, 278, 25481, 10.1074/jbc.M301403200

Shah, 2006, Short chain fatty acids induce TH gene expression via ERK-dependent phosphorylation of CREB protein, Brain Res, 1107, 13, 10.1016/j.brainres.2006.05.097

Moore, 2002, A role for electronic coupling in the striatum in the expression of dopamine receptor-mediated stereotypies, Neuropsychopharmacology, 27, 980, 10.1016/S0893-133X(02)00383-4

Crawley, 2004, Designing mouse behavioural tasks relevant to autistic-like behaviours, Ment Retard Dev Disabil Res Rev, 10, 248, 10.1002/mrdd.20039

Maimburg, 2006, Perinatal risk factors and infantile autism, Acta Psychiatr Scand, 114, 257, 10.1111/j.1600-0447.2006.00805.x

Rinehart, 2006, Gait function in newly diagnosed children with autism: cerebellar and basal-ganglia related motor disorder, Dev Med Child Neurol, 48, 819, 10.1017/S0012162206001769

Chugani, 2004, Serotonin in autism and pediatric epilepsies, Ment Retard Dev Disabil Res Rev, 10, 112, 10.1002/mrdd.20021

Casini, 2003, Carbonic anhydrase activators. The selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram are strong activators of isozymes I and II, Bioorg Med Chem Lett, 13, 2765, 10.1016/S0960-894X(03)00507-9

Song, 2004, Real-time PCR quantification of clostridia in feces of autistic children, Appl Environ Microbiol, 70, 6459, 10.1128/AEM.70.11.6459-6465.2004