Điều trị kháng nhiễm ở bệnh nhân béo phì – "đơn giản là gấp đôi?"

P. Simon1
1Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Universitätsklinikum Leipzig AöR, Leipzig, Deutschland

Tóm tắt

Để đạt hiệu quả tối ưu trong điều trị kháng nhiễm, việc sử dụng kháng sinh một cách thích hợp là rất quan trọng. Ngoài việc lựa chọn kháng sinh phù hợp và thời gian điều trị, liều lượng cũng đóng vai trò quyết định. Béo phì ảnh hưởng đến dược động học của kháng sinh, điều này có thể dẫn đến việc sử dụng liều lượng không đủ khi áp dụng các phác đồ liều không phụ thuộc vào trọng lượng hiện có. Vì vậy, cần thiết phải tiến hành các đo lường hệ thống về nồng độ ở những bệnh nhân béo phì. Đã quan sát thấy sự khác nhau về dược động học giữa huyết tương và dịch kẽ của các mô mục tiêu đối với các loại kháng sinh khác nhau, do đó việc đo lường cũng cần thực hiện ở mô mục tiêu. Kỹ thuật thẩm phân vi mô là phương pháp thích hợp nhất để thực hiện việc đo lường nồng độ một cách liên tục ngay cả trong mô mục tiêu.

Từ khóa


Tài liệu tham khảo

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