Aerogene Tumoraussaat (STAS)

Springer Science and Business Media LLC - Tập 39 - Trang 236-241 - 2018
A. Warth1, L. Fink1
1ÜGP MVZ, Institut für Pathologie, Zytologie und Molekularpathologie Gießen/Wetzlar/Limburg, Wetzlar, Deutschland

Tóm tắt

Nach erfolgreicher Validierung in unabhängigen amerikanischen und deutschen Kohorten pulmonaler Adenokarzinome wurde das Konzept einer aerogenen Tumoraussaat (STAS, „spread through air spaces“) erstmals in der WHO(„World Health Organization“)-Klassifikation von 2015 offiziell eingeführt und daraufhin in weiteren Arbeiten validiert. Der vorliegende Artikel soll eine Übersicht über das aktuelle Konzept dieses neuen Invasionskriteriums bieten.

Tài liệu tham khảo

Bains S, Eguchi T, Warth A et al (2017) PUB016 A multi-national cohort validation of procedure-specific nomograms to predict recurrence for small lung adenocarcinomas. J Thorac Oncol 12:S766 Blaauwgeers HJ, Flieder DB, Warth A et al (2017) A prospective study of loose tissue fragments in non-small cell lung cancer resection specimens: an alternative view to „Spread Through Air Spaces“. Am J Surg Pathol 41:1226–1230 Blaauwgeers HJ, Flieder DB, Warth A et al (2017) A prospective study of „spread through a knife surface“ (STAKS) in non-small cell lung cancer resection specimens. J Thorac Oncol 12:S1123–S1124 Dai C, Xie H, Su H et al (2017) Tumor spread through air spaces affects the recurrence and overall survival in patients with lung adenocarcinoma 〉2 to 3 cm. J Thorac Oncol 12:1052–1060 Clayton F (1986) Bronchioloalveolar carcinomas. Cell types, patterns of growth, and prognostic correlates. Cancer 57:1555–1564 Eguchi T, Kameda K, Lu S et al (2017) OA07.06 in early-stage lung adenocarcinomas, survival by tumor size (T) is further stratified by tumor spread through air spaces. J Thorac Oncol 12:S270–S271 Flechsig P, Kunz J, Heussel CP et al (2015) Invasive lung cancer staging: influence of CT-guided core needle biopsy on onset of pleural carcinomatosis. Clin Imaging 39:56–61 Isaka T, Yokose T, Miyagi Y et al (2017) Detection of tumor spread through airspaces by airway secretion cytology from resected lung cancer specimens. Pathol Int 67:487–494 Kadota K, Kushida Y, Katsuki N et al (2017) Tumor spread through air spaces is an independent predictor of recurrence-free survival in patients with resected lung squamous cell carcinoma. Am J Surg Pathol 41:1077–1086 Kadota K, Nitadori J, Sima CS et al (2015) Tumor spread through air spaces is an important pattern of invasion and impacts the frequency and location of recurrences after limited resection for small stage I lung adenocarcinomas. J Thorac Oncol 10:806–814 Kadota K, Nitadori J, Woo KM et al (2014) Comprehensive pathological analyses in lung squamous cell carcinoma: single cell invasion, nuclear diameter, and tumor budding are independent prognostic factors for worse outcomes. J Thorac Oncol 9:1126–1139 Kameda K, Lu S, Eguchi T et al (2017) MA12.05 can tumor Spread through Air Spaces (STAS) in lung adenocarcinomas be predicted pre- and intraoperatively? J Thorac Oncol 12:S411–412 Kuner R, Muley T, Meister M et al (2009) Global gene expression analysis reveals specific patterns of cell junctions in non-small cell lung cancer subtypes. Lung Cancer 63:32–38 Lu S, Rekhtman N, Eguchi T et al (2017) Cases demonstrating Spread Through Air Spaces (STAS) reflects invasive gGrowth and not an artifact. J Thorac Oncol 12:S1137 Lu S, Tan KS, Kadota K et al (2017) Spread Through Air Spaces (STAS) is an independent predictor of recurrence and lung cancer specific death in squamous cell carcinoma. J Thorac Oncol 12:223–234 Masai K, Sakurai H, Sukeda A et al (2017) Prognostic impact of margin distance and tumor spread through air spaces in limited resection for primary lung cancer. J Thorac Oncol 12:1788–1797 Masuda R, Kijima H, Imamura N et al (2012) Tumor budding is a significant indicator of a poor prognosis in lung squamous cell carcinoma patients. Mol Med Rep 6:937–943 Morales-Oyarvide V, Mino-Kenudson M (2016) Tumor islands and spread through air spaces: distinct patterns of invasion in lung adenocarcinoma. Pathol Int 66:1–7 Morimoto J, Nakajima T, Suzuki H et al (2016) Impact of free tumor clusters on prognosis after resection of pulmonary adenocarcinoma. J Thorac Cardiovasc Surg 152:64–72 Nakajima T, Anayama T, Matsuda Y et al (2014) Orthotopic lung cancer murine model by nonoperative transbronchial approach. Ann Thorac Surg 97:1771–1775 Onozato ML, Klepeis VE, Yagi Y et al (2012) A role of three-dimensional (3D)-reconstruction in the classification of lung adenocarcinoma. Anal Cell Pathol 35:79–84 Onozato ML, Kovach AE, Yeap BY et al (2013) Tumor islands in resected early-stage lung adenocarcinomas are associated with unique clinicopathologic and molecular characteristics and worse prognosis. Am J Surg Pathol 37:287–294 Shiono S, Ishii G, Nagai K et al (2005) Predictive factors for local recurrence of resected colorectal lung metastases. Ann Thorac Surg 80:1040–1045 Shiono S, Ishii G, Nagai K et al (2005) Histopathologic prognostic factors in resected colorectal lung metastases. Ann Thorac Surg 79:278–282 (discussion 283) Shiono S, Yanagawa N (2016) Spread through air spaces is a predictive factor of recurrence and a prognostic factor in stage I lung adenocarcinoma. Interact Cardiovasc Thorac Surg 23:567–572 Thunnissen E, Blaauwgeers HJ, De Cuba EM et al (2016) Ex vivo artifacts and histopathologic pitfalls in the lung. Arch Pathol Lab Med 140:212–220 Trejo Bittar HE, Incharoen P, Althouse AD et al (2015) Accuracy of the IASLC/ATS/ERS histological subtyping of stage I lung adenocarcinoma on intraoperative frozen sections. Mod Pathol 28:1058–1063 Uruga H, Fujii T, Fujimori S et al (2017) Semiquantitative assessment of tumor Spread through Air Spaces (STAS) in early-stage lung adenocarcinomas. J Thorac Oncol 12:1046–1051 Walts AE, Marchevsky AM (2018) Current evidence does not warrant frozen section evaluation for the presence of tumor spread through alveolar spaces. Arch Pathol Lab Med 142:59–63 Warth A (2017) Spread through air spaces (STAS): a comprehensive update translational lung. Cancer Res 6:501–507 Warth A (2017) Spread through air spaces (STAS): prognostic impact of a semi-quantitative assessment. J Thorac Dis 9:1792–1795 Warth A, Beasley MB, Mino-Kenudson M (2017) Breaking new ground: the evolving concept of Spread Through Air Spaces (STAS). J Thorac Oncol 12:176–178 Warth A, Muley T, Harms A et al (2016) Clinical relevance of different papillary growth patterns of pulmonary adenocarcinoma. Am J Surg Pathol 40:818–826 Warth A, Muley T, Kossakowski CA et al (2015) Prognostic impact of intra-alveolar tumor spread in pulmonary adenocarcinoma. Am J Surg Pathol 39:793–801 Weichert W, Kossakowski C, Harms A et al (2016) Proposal of a prognostically relevant grading scheme for pulmonary squamous cell carcinoma. Eur Respir J 47:938–946 Yanagawa N, Shiono S, Abiko M et al (2017) P3.01-002 The clinical impact of spread through air spaces (STAS) in surgically resected pStage I lung squamous cell carcinoma. J Thorac Oncol 12:S1119–S1120 Yeh YC, Nitadori J, Kadota K et al (2015) Using frozen section to identify histological patterns in stage I lung adenocarcinoma of 〈/= 3 cm: accuracy and interobserver agreement. Histopathology 66:922–938 Zhao Y, Shen H, Qiu C et al (2015) Invasion types are associated with poor prognosis in lung squamous carcinoma patients. Medicine (Baltimore) 94:e1634