A New Azaphilone Metabolite from the Fungus Monascus ruber

Chemistry of Natural Compounds - Tập 52 - Trang 231-233 - 2016
Ming-Jen Cheng1, Ming-Der Wu1, Hing-Yuen Chan1, Jih-Jung Chen2, Yen-Chen Cheng3, Yen-Lin Chen1, Ih-Sheng Chen4, Gwo-Fang Yuan1
1Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu, R.O.C.
2Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung, R.O.C.
3Natural Chemical Ind. Co. Ltd, Changhua, R.O.C.
4Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, R.O.C.

Tóm tắt

Phytochemical investigation of the 95% EtOH extract of red yeast rice fermented with the fungus Monascus ruber led to the isolation and structural elucidation of one new azaphilone derivative, monascuspurone (1). The structure was defined on the basis of UV, IR, 1D and 2D NMR (1H–1H COSY, DEPT, HSQC, HMBC), as well as HR-ESI-MS analyses, and comparison of the spectroscopic data with those reported for structurally related compounds.

Tài liệu tham khảo

A. Endo, J. Med. Chem., 28, 401 (1985).

J. Ma, Y. Li, Q. Ye, J. Li, Y. Hua, D. Ju, D. Zhang, R. Cooper, and M. Chang, J. Agric. Food Chem., 48, 5220 (2000).

A. Endo, J. Antibiot., 32, 852 (1979).

Y. Aniya, I. I. Ohtani, T. Higa, C. Miyagi, H. Gibo, M. Shimabukuro, H. Nakanish, and J. Taira, Free Radic. Biol. Med., 286, 999 (1999).

Y. Kohama, S. Matsumoto, T. Mimura, N. Tanabe, A. Inada, and T. Nakanishi, Chem. Pharm. Bull., 35, 2484 (1987).

T. Akihisa, H. Tokuda, K. Yasukawa, M. Ukiya, A. Kiyota, N. Sakamoto, T. Suzuki, N. Tanabe, and H. Nishino, J. Agric. Food Chem., 53, 562 (2005).

Z. Huang, Y. Xu, L. Li, and Y. Li, J. Agric. Food Chem., 56, 112 (2008).

P. Juzlova, T. Rezanka, L. Martinkova, and V. Kren, Phytochemistry, 43, 151 (1996).

K. Sato, Y. Goda, S. S. Sakamoto, H. Shibata, T. Maitani, and T. Yamada, Chem. Pharm. Bull., 45, 227 (1997).

L. L. Li, J. P. Chen, and L. Y. Kong, Chin. J. Nat. Med., 4, 32 (2006).

D. Wild, G. Toth, and H. U. Humpf, J. Agric. Food Chem., 51, 5493 (2003).

M. O. Loret and S. Morel, J. Agric. Food Chem., 58, 1800 (2010).

M. D. Wu, M. J. Cheng, Y. J. Yech, Y. L. Chen, K. P. Chen, P. H. Yang, I. S. Chen, and G. F. Yuan, Nat. Prod. Res., 27, 1145 (2013).

S. Jongrungruangchok, P. Kittakoop, B. Yongsmith, R. Bavovada, S. Tanasupawat, N. Lartpornmatulee, and Y. Thebtaranonth, Phytochemistry, 65, 2569 (2004).

Thông tin
Thông tin xuất bản

Chemistry of Natural Compounds

Tập 52

231-233

Thông tin tác giả