Gadolinium-conjugated TiO2-DNA oligonucleotide nanoconjugates show prolonged intracellular retention period and T1-weighted contrast enhancement in magnetic resonance images

Tatjana Paunesku1,2,3, Tianyi Ke4, Rohan Dharmakumar3, Nicole Mascheri3, Aiguo Wu1, Barry Lai5, Stefan Vogt5, Jörg Maser5, Kenneth Thurn1, Barbara Szolc-Kowalska1, Andrew Larson3, Raymond C. Bergan2,6, Reed Omary2,3, Debiao Li3, Zheng-Rong Lu4, Gayle E. Woloschak1,2,3,7
1Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
2Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, USA
3Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
4Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah, USA
5X-ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois, USA
6Department of Medicine, Northwestern University, Chicago, Illinois, USA
7Department of Cell and Molecular Biology, Northwestern University, Chicago, Illinois, USA

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