N-(4-{[4-(1H-Benzoimidazol-2-yl)-arylamino]-methyl}-phenyl)-benzamide derivatives as small molecule heparanase inhibitors

Bioorganic & Medicinal Chemistry Letters - Tập 16 - Trang 404-408 - 2006
Yong-Jiang Xu1, Hua-Quan Miao2, Weitao Pan1, Elizabeth C. Navarro2, James R. Tonra3, Stan Mitelman3, M. Margarita Camara3, Dhanvanthri S. Deevi3, Alexander S. Kiselyov1, Paul Kussie2, Wai C. Wong1, Hu Liu1
1Department of Chemistry, ImClone Systems Incorporated, 710 Parkside Avenue, Brooklyn, NY 11226, USA
2Department of Protein Science, ImClone Systems Incorporated, 180 Varick Street, NY 10014, USA
3Department of Experimental Therapeutics, ImClone Systems Incorporated, 180 Varick Street, NY 10014, USA

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