Epithelial SMYD5 Exaggerates IBD by Down-regulating Mitochondrial Functions via Post-Translational Control of PGC-1α Stability

Yuning Hou1, Xiaonan Sun1, Pooneh Tavakoley Gheinani1, Xiaoqing Guan1, Shaligram Sharma1, Yu Zhou1,2, Chengliu Jin3, Zhe Yang4, Anjaparavanda P. Naren5, Jun Yin6, Timothy L. Denning7, Andrew T. Gewirtz7, Yuan Liu8, Zhonglin Xie1, Chunying Li1
1Center for Molecular and Translational Medicine, Georgia State University, Atlanta, Georgia
2Division of Vascular Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China
3Transgenic and Gene Targeting Core, Georgia State University, Atlanta, Georgia
4Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Detroit, Michigan
5Division of Pulmonary Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
6Center for Diagnostics and Therapeutics, Department of Chemistry, Georgia State University, Atlanta, Georgia
7Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia
8Program of Immunology and Cellular Biology, Department of Biology, Georgia State University, Atlanta, Georgia

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