The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes

Yuta Kasagi1, Prasanna M. Chandramouleeswaran2,3, Kelly A. Whelan2,3, Koji Tanaka2,3, Veronique Giroux2,3, Medha Sharma2,3, Joshua Wang1, Alain J. Benitez1, Maureen DeMarshall2, John W. Tobias4, Kathryn E. Hamilton2,3, Gary W. Falk2, Jonathan M. Spergel5,6, Andres J. Klein-Szanto7, Anil K. Rustgi2,3, Amanda B. Muir1,6, Hiroshi Nakagawa2,3
1Division of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
2Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
3University of Pennsylvania Abramson Cancer Center, Philadelphia, Pennsylvania
4Penn Genomic Analysis Core, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
5Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
6Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
7Histopathology Facility and Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania

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