Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with <i>neu</i> Oncogene

American Association for the Advancement of Science (AAAS) - Tập 230 Số 4730 - Trang 1132-1139 - 1985
Lisa M. Coussens1, Teresa L. Yang‐Feng2, Yu-Kuang Liao1, Ellson Chen1, Alane Gray1, John P. McGrath3, Peter H. Seeburg1, Towia A. Libermann4, Joseph Schlessinger4, Uta Francke2, Arthur D. Levinson1, Axel Ullrich1
1Department of Molecular Biology, Genentech, Inc., South San Francisco, CA 94080.
2Department of Human Genetics at Yale University School of Medicine, New Haven, CT 06510.
3Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142
4Department of Chemical Immunology at the Weizmann Institute of Science, Rehovot 76100, Israel.

Tóm tắt

A novel potential cell surface receptor of the tyrosine kinase gene family has been identified and characterized by molecular cloning. Its primary sequence is very similar to that of the human epidermal growth factor receptor and the v-erbB oncogene product; the chromosomal location of the gene for this protein is coincident with the neu oncogene, which suggests that the two genes may be identical.

Từ khóa


Tài liệu tham khảo

CYTOGENET CELL GENET 31: 1 (1981).

ANDERSON, S.J., MONOCLONAL-ANTIBODIES TO THE TRANSFORMATION-SPECIFIC GLYCOPROTEIN ENCODED BY THE FELINE RETROVIRAL ONCOGENE V-FMS, JOURNAL OF VIROLOGY 44: 696 (1982).

AVRUCH, J, INSULIN-STIMULATED TYROSINE PHOSPHORYLATION OF THE INSULIN-RECEPTOR IN DETERGENT EXTRACTS OF HUMAN PLACENTAL MEMBRANES - COMPARISON TO EPIDERMAL GROWTH FACTOR-STIMULATED PHOSPHORYLATION, JOURNAL OF BIOLOGICAL CHEMISTRY 257: 5162 (1982).

BARKER, W.C., VIRAL SRC GENE-PRODUCTS ARE RELATED TO THE CATALYTIC CHAIN OF MAMMALIAN CAMP-DEPENDENT PROTEIN-KINASE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 2836 (1982).

CATHALA, G, DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY 2: 329 (1983).

CREA, R, SYNTHESIS OF OLIGONUCLEOTIDES ON CELLULOSE BY A PHOSPHOTRIESTER METHOD, NUCLEIC ACIDS RESEARCH 8: 2331 (1980).

Dayhoff M. O. Atlas of Protein Sequence and Structure 5 3 (1978).

10.1126/science.6304883

10.1038/307521a0

DOWNWARD, J, AUTOPHOSPHORYLATION SITES ON THE EPIDERMAL GROWTH-FACTOR RECEPTOR, NATURE 311: 483 (1984).

EK, B, STIMULATION OF TYROSINE-SPECIFIC PHOSPHORYLATION BY PLATELET-DERIVED GROWTH-FACTOR, NATURE 295: 419 (1982).

FRANCKE, U, RANDOM-X INACTIVATION RESULTING IN MOSAIC NULLISOMY OF REGION XP21.1-]P21.3 ASSOCIATED WITH HETEROZYGOSITY FOR ORNITHINE TRANSCARBAMYLASE DEFICIENCY AND FOR CHRONIC GRANULOMATOUS-DISEASE, CYTOGENETICS AND CELL GENETICS 38: 298 (1984).

FRANCKE, U, ASSIGNMENT OF MAJOR HISTOCOMPATIBILITY COMPLEX TO A REGION OF SHORT ARM OF HUMAN CHROMOSOME-6, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 74: 1147 (1977).

FRANCKE, U, REQUIREMENT OF THE HUMAN CHROMOSOME-11 LONG ARM FOR REPLICATION OF HERPES-SIMPLEX VIRUS TYPE-1 IN NON-PERMISSIVE CHINESE-HAMSTER X HUMAN-DIPLOID FIBROBLAST HYBRIDS, SOMATIC CELL GENETICS 7: 171 (1981).

FRANKS, S, A NOTE ON NP-STRUCTURE AND S DELETION, LINGUISTIC INQUIRY 14: 175 (1983).

GRAY, A, NUCLEOTIDE-SEQUENCE OF EPIDERMAL GROWTH-FACTOR CDNA PREDICTS A 128,000-MOLECULAR WEIGHT PROTEIN-PRECURSOR, NATURE 303: 722 (1983).

Guroff G. Growth and Maturation Factors 1 (1983).

HARPER, M.E., LOCALIZATION OF SINGLE COPY DNA-SEQUENCES ON G-BANDED HUMAN-CHROMOSOMES BY INSITU HYBRIDIZATION, CHROMOSOMA 83: 431 (1981).

HUNTER, T, PROTEIN-TYROSINE KINASES, ANNUAL REVIEW OF BIOCHEMISTRY 54: 897 (1985).

HUNTER, T, PROTEIN KINASE-C PHOSPHORYLATION OF THE EGF RECEPTOR AT A THREONINE RESIDUE CLOSE TO THE CYTOPLASMIC FACE OF THE PLASMA-MEMBRANE, NATURE 311: 480 (1984).

Huynh T. Practical Approaches in Biochemistry (1984).

JACOBS, S, SOMATOMEDIN-C STIMULATES THE PHOSPHORYLATION OF THE BETA-SUBUNIT OF ITS OWN RECEPTOR, JOURNAL OF BIOLOGICAL CHEMISTRY 258: 9581 (1983).

KASUGA, M, INSULIN STIMULATION OF PHOSPHORYLATION OF THE BETA-SUBUNIT OF THE INSULIN-RECEPTOR - FORMATION OF BOTH PHOSPHOSERINE AND PHOSPHOTYROSINE, JOURNAL OF BIOLOGICAL CHEMISTRY 257: 9891 (1982).

10.1038/298667a0

10.1126/science.7031900

10.1126/science.2992089

KOZAK, M, POSSIBLE ROLE OF FLANKING NUCLEOTIDES IN RECOGNITION OF THE AUG INITIATOR CODON BY EUKARYOTIC RIBOSOMES, NUCLEIC ACIDS RESEARCH 9: 5233 (1981).

10.1016/0022-2836(82)90515-0

LAWN, R.M., ISOLATION AND CHARACTERIZATION OF LINKED DELTA-GLOBIN AND BETA-GLOBIN GENES FROM A CLONED LIBRARY OF HUMAN DNA, CELL 15: 1157 (1978).

LEHRACH, H, RNA MOLECULAR-WEIGHT DETERMINATIONS BY GEL-ELECTROPHORESIS UNDER DENATURING CONDITIONS, A CRITICAL RE-EXAMINATION, BIOCHEMISTRY 16: 4743 (1977).

MANGER, R, CELL-SURFACE EXPRESSION OF THE MCDONOUGH STRAIN OF FELINE SARCOMA-VIRUS FMS GENE-PRODUCT (GP140FMS), CELL 39: 327 (1984).

10.1126/science.6200934

MESSING, J, A NEW PAIR OF M13 VECTORS FOR SELECTING EITHER DNA STRAND OF DOUBLE-DIGEST RESTRICTION FRAGMENTS, GENE 19: 269 (1982).

MESSING, J, A SYSTEM FOR SHOTGUN DNA SEQUENCING, NUCLEIC ACIDS RESEARCH 9: 309 (1981).

MOLLER, W, PHOSPHATE-BINDING SEQUENCES IN NUCLEOTIDE-BINDING PROTEINS, FEBS LETTERS 186: 1 (1985).

PETRUZZELLI, L.M., INSULIN ACTIVATES A TYROSINE-SPECIFIC PROTEIN-KINASE IN EXTRACTS OF 3T3-L1 ADIPOCYTES AND HUMAN-PLACENTA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 6792 (1982).

PFEFFER, S, EPIDERMAL GROWTH-FACTOR - IS THE PRECURSOR A RECEPTOR, NATURE 313: 184 (1985).

PRIVALSKY, M.L., THE MEMBRANE GLYCOPROTEIN ENCODED BY THE RETROVIRAL ONCOGENE V-ERB-B IS STRUCTURALLY RELATED TO TYROSINE-SPECIFIC PROTEIN-KINASES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81: 704 (1984).

RETTENMIER, C.W., TRANSMEMBRANE ORIENTATION OF GLYCOPROTEINS ENCODED BY THE V-FMS ONCOGENE, CELL 40: 971 (1985).

RIEDEL H unpublished data.

10.1126/science.6849137

ROUSSEL, M.F., CELL-SURFACE EXPRESSION OF V-FMS-CODED GLYCOPROTEINS IS REQUIRED FOR TRANSFORMATION, MOLECULAR AND CELLULAR BIOLOGY 4: 1999 (1984).

RUBIN, J.B., STIMULATION OF TYROSINE-SPECIFIC PHOSPHORYLATION INVITRO BY INSULIN-LIKE GROWTH FACTOR-I, NATURE 305: 438 (1983).

10.1073/pnas.74.12.5463

SCHECHTER, A.L., THE NEU ONCOGENE - AN ERB-B-RELATED GENE ENCODING A 185,000-MR TUMOR-ANTIGEN, NATURE 312: 513 (1984).

10.1126/science.2992090

10.1126/science.6602382

SHERR, C.J., THE C-FMS PROTO-ONCOGENE PRODUCT IS RELATED TO THE RECEPTOR FOR THE MONONUCLEAR PHAGOCYTE GROWTH-FACTOR, CSF-1, CELL 41: 665 (1985).

SHIA, M.A., THE BETA-SUBUNIT OF THE INSULIN-RECEPTOR IS AN INSULIN-ACTIVATED PROTEIN-KINASE, BIOCHEMISTRY 22: 717 (1983).

10.1038/290261a0

SOUTHERN, E, METHODS IN ENZYMOLOGY 68: 152 (1979).

STERNBERG, MJE, MODELING THE ATP-BINDING SITE OF ONCOGENE PRODUCTS, THE EPIDERMAL GROWTH-FACTOR RECEPTOR AND RELATED PROTEINS, FEBS LETTERS 175: 387 (1984).

TAYLOR, J.M., EFFICIENT TRANSCRIPTION OF RNA INTO DNA BY AVIAN-SARCOMA VIRUS POLYMERASE, BIOCHIMICA ET BIOPHYSICA ACTA 442: 324 (1976).

ULLRICH, A, ISOLATION OF THE HUMAN INSULIN-LIKE GROWTH FACTOR-I GENE USING A SINGLE SYNTHETIC DNA PROBE, EMBO JOURNAL 3: 361 (1984).

ULLRICH, A, HUMAN EPIDERMAL GROWTH-FACTOR RECEPTOR CDNA SEQUENCE AND ABERRANT EXPRESSION OF THE AMPLIFIED GENE IN A431 EPIDERMOID CARCINOMA-CELLS, NATURE 309: 418 (1984).

ULLRICH, A, HUMAN INSULIN-RECEPTOR AND ITS RELATIONSHIP TO THE TYROSINE KINASE FAMILY OF ONCOGENES, NATURE 313: 756 (1985).

VANOBBERGHEN, E, RECEPTOR-MEDIATED PHOSPHORYLATION OF THE HEPATIC INSULIN-RECEPTOR - EVIDENCE THAT THE MR95,000 RECEPTOR SUBUNIT IS ITS OWN KINASE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 80: 945 (1983).

VENNSTROM, B, MOLECULAR-CLONING OF THE AVIAN ERYTHROBLASTOSIS VIRUS GENOME AND RECOVERY OF ONCOGENIC VIRUS BY TRANSFECTION OF CHICKEN-CELLS, JOURNAL OF VIROLOGY 36: 575 (1980).

WAHL, G.M., EFFICIENT TRANSFER OF LARGE DNA FRAGMENTS FROM AGAROSE GELS TO DIAZOBENZYLOXYMETHYL-PAPER AND RAPID HYBRIDIZATION BY USING DEXTRAN SULFATE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 76: 3683 (1979).

10.1038/304035a0

10.1126/science.6324343

YAMAMOTO, T, THE ERBB GENE OF AVIAN ERYTHROBLASTOSIS VIRUS IS A MEMBER OF THE SRC GENE FAMILY, CELL 35: 71 (1983).

YAMAMOTO, T, THE HUMAN LDL RECEPTOR - A CYSTEINE-RICH PROTEIN WITH MULTIPLE ALU SEQUENCES IN ITS MESSENGER-RNA, CELL 39: 27 (1984).

10.1126/science.1257746

ZICK, Y, CHARACTERIZATION OF INSULIN-MEDIATED PHOSPHORYLATION OF THE INSULIN-RECEPTOR IN A CELL-FREE SYSTEM, JOURNAL OF BIOLOGICAL CHEMISTRY 258: 75 (1983).