Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice

JHEP Reports - Tập 5 - Trang 100651 - 2023
Klaus Seedorf1, Csaba Weber2, Cedric Vinson3, Sylvie Berger4, Laurent-Michel Vuillard4, Arpad Kiss2, Stephanie Creusot1, Olivier Broux1, Anne Geant1, Catherine Ilic1, Karine Lemaitre1, Johann Richard4, Adel Hammoutene1,5, Julien Mahieux3, Virginie Martiny4, Didier Durand4, Fabien Melchiore4, Miklos Nyerges2, Valerie Paradis6, Nicolas Provost1
1Cardiovascular and Metabolic Diseases Research, Institut de Recherches Servier, Suresnes, France
2Servier Research Institute of Medicinal Chemistry, Záhony u. 7, H-1031 Budapest, Hungary
3Technologie Servier, 27 Rue Eugène Vignat, 45000 Orleans, France
4Institut de Recherche Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France
5Université Paris Cité, Inserm, Centre de Recherche sur l'inflammation, F-75018, Paris, France
6Département de Pathologie, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, France

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