Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer’s disease: a pilot study

Neurobiology of Aging - Tập 86 - Trang 54-63 - 2020
Bryan J. Neth1,2, Akiva Mintz3,4, Christopher Whitlow3, Youngkyoo Jung3, Kiran Solingapuram Sai3, Thomas C. Register5, Derek Kellar1, Samuel N. Lockhart1, Siobhan Hoscheidt6, Joseph Maldjian3,7, Amanda J. Heslegrave8,9, Kaj Blennow10,11, Stephen C. Cunnane12, Christian-Alexandre Castellano12, Henrik Zetterberg8,9,10,11, Suzanne Craft1
1Department of Internal Medicine , Wake Forest School of Medicine , Winston-Salem, NC , USA.
2Department of Neurology, Mayo Clinic, Rochester, MN, USA
3Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA
4Department of Radiology, Columbia University, New York, NY, USA
5Department of Pathology - Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA
6Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA
7Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
8Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK
9UK Dementia Research Institute at UCL, London, UK
10Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden
11Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
12Research Centre on Aging, Université de Sherbrooke, Sherbrooke, Quebec, Canada

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