Relationships between serum Omentin‐1 levels and bone mineral density in older men with osteoporosis

Chronic Diseases and Translational Medicine - Tập 2 - Trang 48-54 - 2016
Li Yang1, Xin-Lan Zhao1, Bin Liao1, Ai-Ping Qin1
1Department of Endocrinology, Hunan Province Geriatric Hospital, Changsha, Hunan 410001, China

Tóm tắt

AbstractObjectiveTo investigate the correlation between serum Omentin‐1 levels and the presence of osteoporosis in older men.MethodsSerum Omentin‐1, bone turnover biochemical markers, and bone mineral density (BMD) were determined in 45 older men with osteoporosis or 45 older men without osteoporosis (65–70 years old).ResultsOmentin‐1 levels were increased in older men with osteoporosis, and the differences remained significant after controlling for fat mass. Omentin‐1 was negatively correlated with BMD. In a multiple linear stepwise regression analysis, Omentin‐1, lean mass, but not fat mass, were independent predictors of BMD for the combined group. Significant negative correlations between Omentin‐1 and bone‐specific alkaline phosphatase (BAP) and bone cross‐linked N‐telopeptides of type Ⅰ collagen (NTX) were found. Omentin‐1 was also independently associated with BMD and bone turnover markers in older men with osteoporosis and control groups that were considered separately.ConclusionsOmentin‐1 is an independent predictor of BMD in older men with osteoporosis, and it is negatively correlated with bone turnover biochemical markers. It is suggested that Omentin‐1 may exert a negative effect on bone mass through the regulation of the osteoblast differentiation in the older men with osteoporosis.

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Chronic Diseases and Translational Medicine

Tập 2

48-54

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