Set-and Code-Specific Activation in the Frontal Cortex: An fMRI Study of Encoding and Retrieval of Faces and Words

Journal of Cognitive Neuroscience - Tập 11 Số 6 - Trang 631-640 - 1999
Kathleen B. McDermott1, Randy L. Buckner1, Steven E. Petersen1, William M. Kelley1, Amy L. Sanders1
1Washington University and Washington University School of Medicine#TAB#

Tóm tắt

Abstract The frontal cortex has been described as playing both “setspecific” and “code-specific” roles in human memory processing. Set specificity refers to the finding of goal-oriented differences in activation patterns (e.g., encoding relative to retrieval). Code specificity refers to the finding of different patterns of activation for different types of stimuli (e.g., verbal/nonverbal). Using a two (code: verbal, nonverbal) by two (set: encoding, retrieval) within-subjects design and fMRI, we explored the influence of type of code and mental set in two regions in the frontal cortex that have been previously shown to be involved in memory. A region in the dorsal extent of the inferior frontal gyrus (BA 6/44) demonstrated code-specific effects. Specifically, an interaction of material type with hemisphere was obtained, such that words produced predominantly left-lateralized activation, whereas unfamiliar faces elicited predominantly right-lateralized activation. A region of the right frontal polar cortex (in or near BA 10), which has been activated in many memory retrieval studies, showed set-specific activation in that it was more active during retrieval than encoding. These data demonstrate that distinct regions in the frontal cortex contribute in systematic yet different ways to human memory processing.

Từ khóa


Tài liệu tham khảo

10.1073/pnas.92.11.5111

10.1111/j.1467-9280.1996.tb00662.x

10.1126/science.281.5380.1185

10.3758/BF03212413

10.1038/7221

10.1006/nimg.1998.0328

10.1006/nimg.1998.0327

10.1523/JNEUROSCI.15-01-00012.1995

10.1523/JNEUROSCI.16-19-06219.1996

10.1162/jocn.1997.9.1.1

10.3758/BF03204507

Conturo T. E., 1996, Society for Neuroscience Abstracts, 22, 7

10.1016/S0022-5371(72)80001-X

10.1523/JNEUROSCI.15-09-05870.1995

10.1006/nimg.1998.0359

10.1093/brain/118.2.401

10.1016/S0166-2236(96)01013-2

10.1002/hbm.460010207

10.1073/pnas.48.10.1765

10.1002/ana.410130511

10.1037/0022-0663.81.3.392

10.1126/science.7618082

10.1073/pnas.93.2.922

10.1097/00001756-199510020-00014

10.1073/pnas.91.6.2008

Kelley W. M., 1999, Society for Neuroscience Abstracts, 24, 760

10.1016/S1364-6613(98)01234-0

10.1016/S0896-6273(00)80474-2

10.3758/BF03207454

10.1006/nimg.1997.0308

10.1093/oxfordjournals.bmb.a070866

10.1038/jcbfm.1989.13

10.1016/S1364-6613(98)01233-9

10.3758/BF03212412

10.1016/S1364-6613(98)01242-X

10.1097/00001756-199512000-00060

10.1006/nimg.1997.0289

10.1073/pnas.92.13.5803

10.1016/S0092-8674(00)81451-8

10.1093/brain/119.6.2073

10.1073/pnas.93.1.321

10.1006/nimg.1997.0305

10.1037/0033-2909.93.3.481

10.1037/0278-7393.6.2.174

10.1073/pnas.89.5.1837

10.1073/pnas.91.6.2016

10.1093/brain/121.10.1985

10.1097/00001756-199811160-00026

10.1126/science.281.5380.1188

10.1006/nimg.1995.1023

Thông tin
Thông tin xuất bản

Journal of Cognitive Neuroscience

Tập 11 Số 6

631-640

Thông tin tác giả