Neuronal Localization of Simian Varicella Virus DNA in Ganglia of Naturally Infected African Green Monkeys

Virus Genes - Tập 28 - Trang 273-276 - 2004
Peter G.E. Kennedy1, Esther Grinfeld1, Vicki Traina-Dorge2, Donald H. Gilden3,4, Ravi Mahalingam3
1Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Scotland, UK
2Department of Microbiology, Tulane Regional Primate Research Center, Covington, USA
3Department of Neurology, University of Colorado Health Sciences Center, Denver, USA
4Department of Microbiology, University of Colorado Health Sciences Center, Denver, USA

Tóm tắt

In situ hybridization analysis of monkey ganglia 2 months after natural infection with simian varicella virus (SVV) revealed SVV DNA only in neurons. These findings parallel the detection of varicella zoster virus in neurons of latently infected human ganglia. Natural exposure to SVV provides a model system to study varicella latency.

Tài liệu tham khảo

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