Functional organization of spatial and nonspatial working memory processing within the human lateral frontal cortex

Proceedings of the National Academy of Sciences of the United States of America - Tập 95 Số 13 - Trang 7721-7726 - 1998
Adrian M. Owen1, Chantal E. Stern1, Rodney B. Look1, Irene Tracey1, Bruce R. Rosen1, Michael Petrides1
1Medical Research Council Applied Psychology Unit, 15 Chaucer Road, Cambridge, CB2 2EF, United Kingdom; Massachusetts General Hospital–Nuclear Magnetic Resonance Center, Building 149, 13th Street, Charlestown, MA 02129; and Cognitive Neuroscience Laboratory, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada

Tóm tắt

The present study used functional magnetic resonance imaging to demonstrate that performance of visual spatial and visual nonspatial working memory tasks involve the same regions of the lateral prefrontal cortex when all factors unrelated to the type of stimulus material are appropriately controlled. These results provide evidence that spatial and nonspatial working memory may not be mediated, respectively, by mid-dorsolateral and mid-ventrolateral regions of the frontal lobe, as widely assumed, and support the alternative notion that specific regions of the lateral prefrontal cortex make identical executive functional contributions to both spatial and nonspatial working memory.

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Thông tin xuất bản

Proceedings of the National Academy of Sciences of the United States of America

Tập 95 Số 13

7721-7726

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